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Nikki Lee

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Dong-Xing Cao; Xiao-Ou Jiang; Ester Khin; Nikki P Y Lee; Zhi-Jie Li; Yick Liang Lum; Guo-Hao Wu; John M Luk
Osteopontin as potential biomarker and therapeutic target in gastric and liver cancers.
Nikki P Y Lee
The blood-biliary barrier, tight junctions and human liver diseases.
John M Luk; Ulrike Philippar; Ronnie T Poon; Peter M Shaw; Felix H Shek; Daniel G Tenen; Kwong F Wong; Chunsheng Zhang; Julja Burchard; Carolyn A Buser; Michele A Cleary; Hongyue Dai; Sheung-Tat Fan; Irena Ivanovska; Chuen Neng Lee; Nikki P Y Lee; Angela M Liu; Mao Mao
DLK1-DIO3 genomic imprinted microRNA cluster at 14q32.2 defines a stemlike subtype of hepatocellular carcinoma associated with poor survival.

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2012: Dong-Xing Cao; Xiao-Ou Jiang; Ester Khin; Nikki P Y Lee; Zhi-Jie Li; Yick Liang Lum; Guo-Hao Wu; John M Luk
Osteopontin as potential biomarker and therapeutic target in gastric and liver cancers.
World journal of gastroenterology : WJG 2012;18(30):3923-30.
2012: Nikki P Y Lee
The blood-biliary barrier, tight junctions and human liver diseases.
Advances in experimental medicine and biology 2012;763():171-85.
2011: John M Luk; Ulrike Philippar; Ronnie T Poon; Peter M Shaw; Felix H Shek; Daniel G Tenen; Kwong F Wong; Chunsheng Zhang; Julja Burchard; Carolyn A Buser; Michele A Cleary; Hongyue Dai; Sheung-Tat Fan; Irena Ivanovska; Chuen Neng Lee; Nikki P Y Lee; Angela M Liu; Mao Mao
DLK1-DIO3 genomic imprinted microRNA cluster at 14q32.2 defines a stemlike subtype of hepatocellular carcinoma associated with poor survival.
The Journal of biological chemistry 2011;286(35):30706-13.
2011: Sarwat Fatima; Nikki P Y Lee; John M Luk
Dickkopfs and Wnt/β-catenin signalling in liver cancer.
World journal of clinical oncology 2011;2(8):311-25.
2010: Nikki P Y Lee; Ronnie T P Poon; Felix H Shek; Irene O L Ng; John Luk
Role of cadherin-17 in oncogenesis and potential therapeutic implications in hepatocellular carcinoma.
Biochimica et biophysica acta 2010;1806(2):138-45.
2010: Rui Zhu; Kwong-Fai Wong; Nikki P Y Lee; Kai-Fai Lee; John Luk
HNF1α and CDX2 transcriptional factors bind to cadherin-17 (CDH17) gene promoter and modulate its expression in hepatocellular carcinoma.
Journal of cellular biochemistry 2010;111(3):618-26.
2010: Lei Chen; David W Ho; Nikki P Y Lee; Stella Sun; Brian Lam; Kwong-Fai Wong; Xin Yi; George K Lau; Eddy W Y Ng; Terence C W Poon; Paul B S Lai; Zongwei Cai; Jirun Peng; Xisheng Leng; Ronnie T P Poon; John Luk
Enhanced detection of early hepatocellular carcinoma by serum SELDI-TOF proteomic signature combined with alpha-fetoprotein marker.
Annals of surgical oncology 2010;17(9):2518-25.
2010: Julja Burchard; Chunsheng Zhang; Angela M Liu; Ronnie T P Poon; Nikki P Y Lee; Kwong-Fai Wong; Pak C Sham; Brian Y Lam; Mark D Ferguson; George Tokiwa; Ryan Smith; Brendan Leeson; Rebecca Beard; John R Lamb; Lee Lim; Mao Mao; Hongyue Dai; John Luk
microRNA-122 as a regulator of mitochondrial metabolic gene network in hepatocellular carcinoma.
Molecular systems biology 2010;6():402.
2010: Stella Sun; Ronnie T P Poon; Nikki P Y Lee; Chun Yeung; K L Chan; Irene O L Ng; Philip J R Day; John Luk
Proteomics of hepatocellular carcinoma: serum vimentin as a surrogate marker for small tumors (
Journal of proteome research 2010;9(4):1923-30.

2009: Michelle Z Xu; Tzy-Jyun Yao; Nikki P Y Lee; Irene O L Ng; Yuk-Tat Chan; Lars Zender; Scott W Lowe; Ronnie T P Poon; John Luk
Yes-associated protein is an independent prognostic marker in hepatocellular carcinoma.
Cancer 2009;115(19):4576-85.
2009: Nikki P Y Lee; Lei Chen; Marie C Lin; Felice H Tsang; Chun Yeung; Ronnie T Poon; Jirun Peng; Xisheng Leng; Laura Beretta; Stella Sun; Philip Day; John Luk
Proteomic expression signature distinguishes cancerous and nonmalignant tissues in hepatocellular carcinoma.
Journal of proteome research 2009;8(3):1293-303.
2009: Ke Hao; John Luk; Nikki P Y Lee; Mao Mao; Chunsheng Zhang; Mark D Ferguson; john lamb; Hongyue Dai; Irene O Ng; Pak C Sham; Ronnie T P Poon
Predicting prognosis in hepatocellular carcinoma after curative surgery with common clinicopathologic parameters.
BMC cancer 2009;9():389.
2009: Felice H Tsang; Nikki P Y Lee; John Luk
The use of small peptides in the diagnosis and treatment of hepatocellular carcinoma.
Protein and peptide letters 2009;16(5):530-8.
2009: Wen Jing Lu; Nikki P Y Lee; Sarwat Fatima; John Luk
Heat shock proteins in cancer: signaling pathways, tumor markers and molecular targets in liver malignancy.
Protein and peptide letters 2009;16(5):508-16.
2009: Stella Sun; Philip Day; Nikki P Y Lee; John Luk
Biomarkers for early detection of liver cancer: focus on clinical evaluation.
Protein and peptide letters 2009;16(5):473-8.
2009: Nikki P Y Lee; Elissa W P Wong; Dolores D Mruk; C Yan Cheng
Testicular cell junction: a novel target for male contraception.
Current medicinal chemistry 2009;16(7):906-15.
2008: Nikki P Y Lee; C Yan Cheng
Nitric oxide and cyclic nucleotides: their roles in junction dynamics and spermatogenesis.
Oxidative medicine and cellular longevity 2008;1(1):25-32.
2008: Kai-Fai Lee; Yuen-Tsung Tam; Yan Zuo; Ana W Y Cheong; Pang Ronald; Nikki P Y Lee; Cathy K Shum; Po-Chor Tam; Annie N Y Cheung; Zeng-Ming Yang; William S B Yeung; John Luk
Characterization of an acrosome protein VAD1.2/AEP2 which is differentially expressed in spermatogenesis.
Molecular human reproduction 2008;14(8):465-74.
2008: Nikki P Y Lee; Kar-wai Leung; Nicole Cheung; Brian Y Lam; Michelle Z Xu; Pak C Sham; George K K Lau; Ronnie T P Poon; Sheung-Tat Fan; John Luk
Comparative proteomic analysis of mouse livers from embryo to adult reveals an association with progression of hepatocellular carcinoma.
Proteomics 2008;8(10):2136-49.
2008: Nikki P Y Lee; C Yan Cheng
Nitric oxide and cyclic nucleotides: their roles in junction dynamics and spermatogenesis.
Advances in experimental medicine and biology 2008;636():172-85.
2007: Stella Sun; Nikki P Y Lee; Ronnie T P Poon; Sheung-Tat Fan; Qing Y He; George K K Lau; John Luk
Oncoproteomics of hepatocellular carcinoma: from cancer markers' discovery to functional pathways.
Liver international : official journal of the International Association for the Study of the Liver 2007;27(8):1021-38.
2007: John Luk; Brian Y Lam; Nikki P Y Lee; David W Ho; Pak C Sham; Lei Chen; Jirun Peng; Xisheng Leng; Philip Day; Sheung-Tat Fan
Artificial neural networks and decision tree model analysis of liver cancer proteomes.
Biochemical and biophysical research communications 2007;361(1):68-73.
2007: Nikki P Y Lee; Siu Tim Cheung; Ronnie T P Poon; Sheung-Tat Fan; John Luk
Genomic and proteomic biomarkers for diagnosis and prognosis of hepatocellular carcinoma.
Biomarkers in medicine 2007;1(2):273-84.
2007: Chee-Kin Hui; Hai-Ying Zhang; Nikki P Y Lee; Weng Chan; Yui-Hung Yueng; Kit-Wah Leung; Lei Lu; Nancy Leung; Chung-Mau Lo; Sheung-Tat Fan; John Luk; Aimin Xu; Karen S Lam; Yok-Lam Kwong; George K K Lau
Serum adiponectin is increased in advancing liver fibrosis and declines with reduction in fibrosis in chronic hepatitis B.
Journal of hepatology 2007;47(2):191-202.
2007: John Luk; Qi-sheng Zhang; Nikki P Y Lee; Jana Y Wo; Pauline P Leung; Ling-Xiao Liu; Mei-Yu Hu; Kwok-Fan Cheung; Chee-Kin Hui; George K K Lau; Sheung-Tat Fan
Hepatic stellate cell-targeted delivery of M6P-HSA-glycyrrhetinic acid attenuates hepatic fibrogenesis in a bile duct ligation rat model.
Liver international : official journal of the International Association for the Study of the Liver 2007;27(4):548-57.
2007: Nikki P Y Lee; Dolores D Mruk; WEILIANG XIA; C Yan Cheng
Cellular localization of sphingomyelin synthase 2 in the seminiferous epithelium of adult rat testes.
The Journal of endocrinology 2007;192(1):17-32.
2007: Nikki P Y Lee; William S B Yeung; John Luk
Junction interaction in the seminiferous epithelium: regulatory roles of connexin-based gap junction.
Frontiers in bioscience : a journal and virtual library 2007;12():1552-62.
2006: John Luk; Nikki P Y Lee; Cathy K Shum; Brian Y Lam; Annie F M Siu; Chi-Ming Che; Po-Chor Tam; Annie N Y Cheung; Z M Yang; Yi-Nan Lin; Martin M Matzuk; Kai-Fai Lee; William S B Yeung
Acrosome-specific gene AEP1: identification, characterization and roles in spermatogenesis.
Journal of cellular physiology 2006;209(3):755-66.
2006: Chee-Kin Hui; Scott Bowden; Hai-Ying Zhang; Anita Wong; Sharon Lewin; Franck Rousseau; Herve Mommeja-Marin; Nikki P Y Lee; John Luk; Stephen Locarnini; Nancy Leung; Nikolai Naoumov; George K K Lau
Comparison of real-time PCR assays for monitoring serum hepatitis B virus DNA levels during antiviral therapy.
Journal of clinical microbiology 2006;44(8):2983-7.
2006: Nikki P Y Lee; Kit-Wah Leung; Jana Y Wo; Po-Chor Tam; William S B Yeung; John Luk
Blockage of testicular connexins induced apoptosis in rat seminiferous epithelium.
Apoptosis : an international journal on programmed cell death 2006;11(7):1215-29.
2006: Nikki P Y Lee; Man K Tong; Pauline P Leung; Vivian W Chan; Simon Leung; Po-Chor Tam; Kwok Wah Chan; Kai-Fai Lee; William S B Yeung; John Luk
Kidney claudin-19: localization in distal tubules and collecting ducts and dysregulation in polycystic renal disease.
FEBS letters 2006;580(3):923-31.
2006: Nikki P Y Lee; Stella Tsang; R Holland Cheng; John Luk
Increased solubility of integrin betaA domain using maltose-binding protein as a fusion tag.
Protein and peptide letters 2006;13(5):431-5.
2005: Marie C Lin; Nikki P Y Lee; Ning Zheng; Pai-Hao Yang; Oscar G Wong; Hsiang-Fu Kung; Chee-Kin Hui; John Luk; George K K Lau
Tumor necrosis factor-alpha-induced protein 1 and immunity to hepatitis B virus.
World journal of gastroenterology : WJG 2005;11(48):7564-8.
2005: C Yan Cheng; Dolores D Mruk; Bruno Silvestrini; Michele Bonanomi; Ching-Hang Wong; Michelle K Y Siu; Nikki P Y Lee; Wing-Yee Lui; Meng-yun Mo
AF-2364 [1-(2,4-dichlorobenzyl)-1H-indazole-3-carbohydrazide] is a potential male contraceptive: a review of recent data.
Contraception 2005;72(4):251-61.
2005: WEILIANG XIA; Ching-Hang Wong; Nikki P Y Lee; Will M Lee; C Yan Cheng
Disruption of Sertoli-germ cell adhesion function in the seminiferous epithelium of the rat testis can be limited to adherens junctions without affecting the blood-testis barrier integrity: an in vivo study using an androgen suppression model.
Journal of cellular physiology 2005;205(1):141-57.
2005: Nikki P Y Lee; Dolores D Mruk; Ching-Hang Wong; C Yan Cheng
Regulation of Sertoli-germ cell adherens junction dynamics in the testis via the nitric oxide synthase (NOS)/cGMP/protein kinase G (PRKG)/beta-catenin (CATNB) signaling pathway: an in vitro and in vivo study.
Biology of reproduction 2005;73(3):458-71.
2005: Chee-Kin Hui; Jian Sun; Wing Y Au; A K W Lie; Yui-Hung Yueng; Hai-ying Zhang; Nikki P Y Lee; Jin-ling Hou; Raymond Liang; George K K Lau
Occult hepatitis B virus infection in hematopoietic stem cell donors in a hepatitis B virus endemic area.
Journal of hepatology 2005;42(6):813-9.
2005: Ching-Hang Wong; WEILIANG XIA; Nikki P Y Lee; Dolores D Mruk; Will M Lee; C Yan Cheng
Regulation of ectoplasmic specialization dynamics in the seminiferous epithelium by focal adhesion-associated proteins in testosterone-suppressed rat testes.
Endocrinology 2005;146(3):1192-204.
2005: Jiayi Zhang; Ching-Hang Wong; WEILIANG XIA; Dolores D Mruk; Nikki P Y Lee; Will M Lee; C Yan Cheng
Regulation of Sertoli-germ cell adherens junction dynamics via changes in protein-protein interactions of the N-cadherin-beta-catenin protein complex which are possibly mediated by c-Src and myotubularin-related protein 2: an in vivo study using an androgen suppression model.
Endocrinology 2005;146(3):1268-84.
2005: Nikki P Y Lee; C Yan Cheng
Protein kinases and adherens junction dynamics in the seminiferous epithelium of the rat testis.
Journal of cellular physiology 2005;202(2):344-60.
2004: Nikki P Y Lee; C Yan Cheng
Adaptors, junction dynamics, and spermatogenesis.
Biology of reproduction 2004;71(2):392-404.
2004: Nikki P Y Lee; C Yan Cheng
Ectoplasmic specialization, a testis-specific cell-cell actin-based adherens junction type: is this a potential target for male contraceptive development?
Human reproduction update 2004;10(4):349-69.
2004: Nikki P Y Lee; Dolores D Mruk; Anne M Conway; C Yan Cheng
Zyxin, axin, and Wiskott-Aldrich syndrome protein are adaptors that link the cadherin/catenin protein complex to the cytoskeleton at adherens junctions in the seminiferous epithelium of the rat testis.
Journal of andrology 2004;25(2):200-15.
2004: Nikki P Y Lee; C Yan Cheng
Nitric oxide/nitric oxide synthase, spermatogenesis, and tight junction dynamics.
Biology of reproduction 2004;70(2):267-76.
2003: Yong-mei Chen; Nikki P Y Lee; Dolores D Mruk; Will M Lee; C Yan Cheng
Fer kinase/FerT and adherens junction dynamics in the testis: an in vitro and in vivo study.
Biology of reproduction 2003;69(2):656-72.
2003: Dolores D Mruk; Michelle K Y Siu; Anne M Conway; Nikki P Y Lee; Ann S N Lau; C Yan Cheng
Role of tissue inhibitor of metalloproteases-1 in junction dynamics in the testis.
Journal of andrology 2003;24(4):510-23.
2003: Nikki P Y Lee; C Yan Cheng
Regulation of Sertoli cell tight junction dynamics in the rat testis via the nitric oxide synthase/soluble guanylate cyclase/3',5'-cyclic guanosine monophosphate/protein kinase G signaling pathway: an in vitro study.
Endocrinology 2003;144(7):3114-29.
2003: Nikki P Y Lee; Dolores D Mruk; Will M Lee; C Yan Cheng
Is the cadherin/catenin complex a functional unit of cell-cell actin-based adherens junctions in the rat testis?
Biology of reproduction 2003;68(2):489-508.