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Patrick Lee

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TOP 3
Da Pan; Lu-Zhe Pan; Maya Shmulevitz; Dae-Gyun Ahn; Shashi A Gujar; Paola Marcato; Patrick W K Lee
Activation of p53 by chemotherapeutic agents enhances reovirus oncolysis.
Andrew M Leidal; Patrick W K Lee; Craig McCormick
Viral subversion of autophagy impairs oncogene-induced senescence.
Maya Shmulevitz; Adil Mohamed; Dae-Gyun Ahn; Shashi A Gujar; Patrick W K Lee
Reovirus variants with mutations in genome segments S1 and L2 exhibit enhanced virion infectivity and superior oncolysis.

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All Publications

2013: Da Pan; Lu-Zhe Pan; Maya Shmulevitz; Dae-Gyun Ahn; Shashi A Gujar; Paola Marcato; Patrick W K Lee
Activation of p53 by chemotherapeutic agents enhances reovirus oncolysis.
PloS one 2013;8(1):e54006.
2012: Andrew M Leidal; Patrick W K Lee; Craig McCormick
Viral subversion of autophagy impairs oncogene-induced senescence.
Autophagy 2012;8(7):1138-40.
2012: Maya Shmulevitz; Adil Mohamed; Dae-Gyun Ahn; Shashi A Gujar; Patrick W K Lee
Reovirus variants with mutations in genome segments S1 and L2 exhibit enhanced virion infectivity and superior oncolysis.
Journal of virology 2012;86(13):7403-13.
2012: Andrew M Leidal; David P Cyr; Richard J Hill; Patrick W K Lee; Craig McCormick
Subversion of autophagy by Kaposi's sarcoma-associated herpesvirus impairs oncogene-induced senescence.
Cell host & microbe 2012;11(2):167-80.
2012: Patricia A Madureira; Richard Hill; Patrick W K Lee; David M Waisman
Genotoxic agents promote the nuclear accumulation of annexin A2: role of annexin A2 in mitigating DNA damage.
PloS one 2012;7(11):e50591.
2012: Maya Shmulevitz; Patrick W K Lee
Exploring host factors that impact reovirus replication, dissemination, and reovirus-induced cell death in cancer versus normal cells in culture.
Methods in molecular biology (Clifton, N.J.) 2012;797():163-76.
2011: Richard Hill; Patricia A Madureira; David M Waisman; Patrick W K Lee
DNA-PKCS binding to p53 on the p21WAF1/CIP1 promoter blocks transcription resulting in cell death.
Oncotarget 2011;2(12):1094-108.
2011: Paola Marcato; Cheryl A Dean; Carman A Giacomantonio; Patrick W K Lee
Aldehyde dehydrogenase: its role as a cancer stem cell marker comes down to the specific isoform.
Cell cycle (Georgetown, Tex.) 2011;10(9):1378-84.
2011: Paola Marcato; Cheryl A Dean; Da Pan; Rakhna Araslanova; Megan Gillis; Madalsa Joshi; Lucy Helyer; Luzhe Pan; Andrew Leidal; Shashi Gujar; Carman A Giacomantonio; Patrick W K Lee
Aldehyde dehydrogenase activity of breast cancer stem cells is primarily due to isoform ALDH1A3 and its expression is predictive of metastasis.
Stem cells (Dayton, Ohio) 2011;29(1):32-45.
2010: Shashi A Gujar; Paola Marcato; Da Pan; Patrick W K Lee
Reovirus virotherapy overrides tumor antigen presentation evasion and promotes protective antitumor immunity.
Molecular cancer therapeutics 2010;9(11):2924-33.
2010: Richard Hill; Patrick W K Lee
The DNA-dependent protein kinase (DNA-PK): More than just a case of making ends meet?
Cell cycle (Georgetown, Tex.) 2010;9(17):3460-9.
2010: Maya Shmulevitz; Lu-Zhe Pan; Katy Garant; Da Pan; Patrick W K Lee
Oncogenic Ras promotes reovirus spread by suppressing IFN-beta production through negative regulation of RIG-I signaling.
Cancer research 2010;70(12):4912-21.
2009: Paola Marcato; Cheryl A Dean; Carman A Giacomantonio; Patrick W K Lee
If cancer stem cells are resistant to current therapies, what's next?
Future oncology (London, England) 2009;5(6):747-50.
2009: Paola Marcato; Cheryl A Dean; Carman A Giacomantonio; Patrick W K Lee
Oncolytic reovirus effectively targets breast cancer stem cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(6):972-9.
2009: Laura D Gillis; Andrew M Leidal; Richard Hill; Patrick W K Lee
p21Cip1/WAF1 mediates cyclin B1 degradation in response to DNA damage.
Cell cycle (Georgetown, Tex.) 2009;8(2):253-6.
2007: Tommy Alain; Josée F Wong; R Endersby; Stefan J Urbanski; Patrick W K Lee; Daniel A Muruve; Randal Johnston; Peter A Forsyth; Paul L Beck
Reovirus decreases azoxymethane-induced aberrant crypt foci and colon cancer in a rodent model.
Cancer gene therapy 2007;14(10):867-72.
2007: Manbok Kim; C Egan; Tommy Alain; Stefan J Urbanski; Patrick W K Lee; Peter A Forsyth; Randal Johnston
Acquired resistance to reoviral oncolysis in Ras-transformed fibrosarcoma cells.
Oncogene 2007;26(28):4124-34.
2006: Tommy Alain; Manbok Kim; Randal Johnston; Stefan J Urbanski; Anna E Kossakowska; Peter A Forsyth; Patrick W K Lee
The oncolytic effect in vivo of reovirus on tumour cells that have survived reovirus cell killing in vitro.
British journal of cancer 2006;95(8):1020-7.
2005: Kara L Norman; Patrick W K Lee
Not all viruses are bad guys: the case for reovirus in cancer therapy.
Drug discovery today 2005;10(12):847-55.
2004: Wen Qing Yang; Xueqing Lun; Cheryl Ann Palmer; M Elizabeth Wilcox; Huong Muzik; Zhong Qiao Shi; Richard H Dyck; Matt Coffey; Brad Thompson; Mark Hamilton; Sandra G Nishikawa; P M A Brasher; Kevin Fonseca; David George; N Barry Rewcastle; Randal Johnston; Doug Stewart; Patrick W K Lee; Donna L Senger; Peter A Forsyth
Efficacy and safety evaluation of human reovirus type 3 in immunocompetent animals: racine and nonhuman primates.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(24):8561-76.
2004: Wen Qing Yang; Donna L Senger; Xueqing Lun; Huong Muzik; Zhong Qiao Shi; Richard H Dyck; Kara L Norman; P M A Brasher; N Barry Rewcastle; David George; Doug Stewart; Patrick W K Lee; Peter A Forsyth
Reovirus as an experimental therapeutic for brain and leptomeningeal metastases from breast cancer.
Gene therapy 2004;11(21):1579-89.
2004: Kara L Norman; Kensuke Hirasawa; An-Dao Yang; Michael A Shields; Patrick W K Lee
Reovirus oncolysis: the Ras/RalGEF/p38 pathway dictates host cell permissiveness to reovirus infection.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(30):11099-104.
2004: Chris D Nicholls; Michael A Shields; Patrick W K Lee; Stephen M Robbins; Tara L Beattie
UV-dependent alternative splicing uncouples p53 activity and PIG3 gene function through rapid proteolytic degradation.
The Journal of biological chemistry 2004;279(23):24171-8.
2004: Melissa T Jack; Richard A Woo; Noboru Motoyama; Hitoyuki Takai; Patrick W K Lee
DNA-dependent protein kinase and checkpoint kinase 2 synergistically activate a latent population of p53 upon DNA damage.
The Journal of biological chemistry 2004;279(15):15269-73.
2004: Sunghoon Jung; Leo A Behie; Patrick W K Lee; Patrick J Farrell
Optimization of reovirus production from mouse L-929 cells in suspension culture.
Biotechnology and bioengineering 2004;85(7):750-60.
2003: Tommy Alain; Chandini M Thirukkumaran; Donald G Morris; Stefan J Urbanski; Anna Janowska-Wieczorek; Patrick W K Lee; Anna E Kossakowska
Lymphomas and oncolytic virus therapy.
Clinical lymphoma 2003;4(2):104-11.
2003: Faris Farassati; Patrick W K Lee
Ras signalling pathway: a gateway for HSV-1 infection.
TheScientificWorldJournal 2003;3():533-5.
2003: Wen Qing Yang; Donna L Senger; Huong Muzik; Zhong Qiao Shi; Denise Johnson; P M A Brasher; N Barry Rewcastle; Mark Hamilton; Jim Rutka; Johannes Wolff; Cynthia Wetmore; Tom Curran; Patrick W K Lee; Peter A Forsyth
Reovirus prolongs survival and reduces the frequency of spinal and leptomeningeal metastases from medulloblastoma.
Cancer research 2003;63(12):3162-72.
2003: Kensuke Hirasawa; Sandra G Nishikawa; Kara L Norman; Matthew C Coffey; Bradley G Thompson; Chang-Soon Yoon; David M Waisman; Patrick W K Lee
Systemic reovirus therapy of metastatic cancer in immune-competent mice.
Cancer research 2003;63(2):348-53.
2002: Tommy Alain; Kensuke Hirasawa; Kelly J Pon; Sandra G Nishikawa; Stefan J Urbanski; Yvonna Auer; Joanne M Luider; Anita Martin; Randal Johnston; Anna Janowska-Wieczorek; Patrick W K Lee; Anna E Kossakowska
Reovirus therapy of lymphoid malignancies.
Blood 2002;100(12):4146-53.
2002: Melissa T Jack; Richard A Woo; Atsushi Hirao; Alison Cheung; Tak W Mak; Patrick W K Lee
Chk2 is dispensable for p53-mediated G1 arrest but is required for a latent p53-mediated apoptotic response.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(15):9825-9.
2002: Richard A Woo; Melissa T Jack; Yang Xu; Sandeep Burma; David J Chen; Patrick W K Lee
DNA damage-induced apoptosis requires the DNA-dependent protein kinase, and is mediated by the latent population of p53.
The EMBO journal 2002;21(12):3000-8.
2002: Chris D Nicholls; Kevin G McLure; Michael A Shields; Patrick W K Lee
Biogenesis of p53 involves cotranslational dimerization of monomers and posttranslational dimerization of dimers. Implications on the dominant negative effect.
The Journal of biological chemistry 2002;277(15):12937-45.
2002: Kara L Norman; Matthew C Coffey; Kensuke Hirasawa; Douglas J Demetrick; Sandra G Nishikawa; Lisa M DiFrancesco; James E Strong; Patrick W K Lee
Reovirus oncolysis of human breast cancer.
Human gene therapy 2002;13(5):641-52.
2002: Kensuke Hirasawa; Sandra G Nishikawa; Kara L Norman; Tommy Alain; Anna E Kossakowska; Patrick W K Lee
Oncolytic reovirus against ovarian and colon cancer.
Cancer research 2002;62(6):1696-701.
2001: Y G Zhao; R Gilmore; G Leone; Matthew C Coffey; B Weber; Patrick W K Lee
Hsp90 phosphorylation is linked to its chaperoning function. Assembly of the reovirus cell attachment protein.
The Journal of biological chemistry 2001;276(35):32822-7.
2001: Faris Farassati; A D Yang; Patrick W K Lee
Oncogenes in Ras signalling pathway dictate host-cell permissiveness to herpes simplex virus 1.
Nature cell biology 2001;3(8):745-50.
2001: M Elizabeth Wilcox; W Yang; Donna L Senger; N Barry Rewcastle; Donald G Morris; P M A Brasher; Zhong Qiao Shi; Randal Johnston; Sandra G Nishikawa; Patrick W K Lee; Peter A Forsyth
Reovirus as an oncolytic agent against experimental human malignant gliomas.
Journal of the National Cancer Institute 2001;93(12):903-12.
2001: Kara L Norman; Faris Farassati; Patrick W K Lee
Oncolytic viruses and cancer therapy.
Cytokine & growth factor reviews 2001;12(2-3):271-82.
2000: Kara L Norman; Patrick W K Lee
Reovirus as a novel oncolytic agent.
The Journal of clinical investigation 2000;105(8):1035-8.
1999: Kevin G McLure; Patrick W K Lee
p53 DNA binding can be modulated by factors that alter the conformational equilibrium.
The EMBO journal 1999;18(3):763-70.
1998: Matthew C Coffey; James E Strong; Peter A Forsyth; Patrick W K Lee
Reovirus therapy of tumors with activated Ras pathway.
Science (New York, N.Y.) 1998;282(5392):1332-4.
1998: Richard A Woo; Kevin G McLure; Susan Lees-Miller; Derrick E Rancourt; Patrick W K Lee
DNA-dependent protein kinase acts upstream of p53 in response to DNA damage.
Nature 1998;394(6694):700-4.
1998: James E Strong; Matthew C Coffey; D Tang; P Sabinin; Patrick W K Lee
The molecular basis of viral oncolysis: usurpation of the Ras signaling pathway by reovirus.
The EMBO journal 1998;17(12):3351-62.
1998: Kevin G McLure; Patrick W K Lee
How p53 binds DNA as a tetramer.
The EMBO journal 1998;17(12):3342-50.
1998: R Gilmore; Matthew C Coffey; Patrick W K Lee
Active participation of Hsp90 in the biogenesis of the trimeric reovirus cell attachment protein sigma1.
The Journal of biological chemistry 1998;273(24):15227-33.
1998: Patrick W K Lee; R Gilmore
Reovirus cell attachment protein sigma 1: structure-function relationships and biogenesis.
Current topics in microbiology and immunology 1998;233(Pt 1):137-53.
1996: Kevin G McLure; Patrick W K Lee
A PAb240+ conformation of wild type p53 binds DNA.
Oncogene 1996;13(6):1297-303.
1996: R Gilmore; Matthew C Coffey; G Leone; Kevin G McLure; Patrick W K Lee
Co-translational trimerization of the reovirus cell attachment protein.
The EMBO journal 1996;15(11):2651-8.
1996: G Leone; Matthew C Coffey; R Gilmore; R Duncan; L Maybaum; Patrick W K Lee
C-terminal trimerization, but not N-terminal trimerization, of the reovirus cell attachment protein Is a posttranslational and Hsp70/ATP-dependent process.
The Journal of biological chemistry 1996;271(14):8466-71.
1996: J E Strong; Patrick W K Lee
The v-erbB oncogene confers enhanced cellular susceptibility to reovirus infection.
Journal of virology 1996;70(1):612-6.
1994: J Fernandes; Damu Tang; G Leone; Patrick W K Lee
Binding of reovirus to receptor leads to conformational changes in viral capsid proteins that are reversible upon virus detachment.
The Journal of biological chemistry 1994;269(25):17043-7.
1994: Patrick W K Lee; G Leone
Reovirus protein sigma 1: from cell attachment to protein oligomerization and folding mechanisms.
BioEssays : news and reviews in molecular, cellular and developmental biology 1994;16(3):199-206.
1993: Damu Tang; J E Strong; Patrick W K Lee
Recognition of the epidermal growth factor receptor by reovirus.
Virology 1993;197(1):412-4.
1993: J E Strong; Damu Tang; Patrick W K Lee
Evidence that the epidermal growth factor receptor on host cells confers reovirus infection efficiency.
Virology 1993;197(1):405-11.
1992: G Leone; L Maybaum; Patrick W K Lee
The reovirus cell attachment protein possesses two independently active trimerization domains: basis of dominant negative effects.
Cell 1992;71(3):479-88.
1992: D L Turner; R Duncan; Patrick W K Lee
Site-directed mutagenesis of the C-terminal portion of reovirus protein sigma 1: evidence for a conformation-dependent receptor binding domain.
Virology 1992;186(1):219-27.
1991: G Leone; R Duncan; Patrick W K Lee
Trimerization of the reovirus cell attachment protein (sigma 1) induces conformational changes in sigma 1 necessary for its cell-binding function.
Virology 1991;184(2):758-61.
1991: J E Strong; G Leone; R Duncan; R K Sharma; Patrick W K Lee
Biochemical and biophysical characterization of the reovirus cell attachment protein sigma 1: evidence that it is a homotrimer.
Virology 1991;184(1):23-32.
1991: R Duncan; D Horne; J E Strong; G Leone; R T Pon; M C Yeung; Patrick W K Lee
Conformational and functional analysis of the C-terminal globular head of the reovirus cell attachment protein.
Virology 1991;182(2):810-9.
1991: G Leone; D C Mah; Patrick W K Lee
The incorporation of reovirus cell attachment protein sigma 1 into virions requires the N-terminal hydrophobic tail and the adjacent heptad repeat region.
Virology 1991;182(1):346-50.
1991: G Leone; R Duncan; D C Mah; A Price; L W Cashdollar; Patrick W K Lee
The N-terminal heptad repeat region of reovirus cell attachment protein sigma 1 is responsible for sigma 1 oligomer stability and possesses intrinsic oligomerization function.
Virology 1991;182(1):336-45.
1990: D C Mah; G Leone; J M Jankowski; Patrick W K Lee
The N-terminal quarter of reovirus cell attachment protein sigma 1 possesses intrinsic virion-anchoring function.
Virology 1990;179(1):95-103.
1990: A H Choi; R W Paul; Patrick W K Lee
Reovirus binds to multiple plasma membrane proteins of mouse L fibroblasts.
Virology 1990;178(1):316-20.
1990: R Duncan; D Horne; L W Cashdollar; W K Joklik; Patrick W K Lee
Identification of conserved domains in the cell attachment proteins of the three serotypes of reovirus.
Virology 1990;174(2):399-409.
1989: R W Paul; A H Choi; Patrick W K Lee
The alpha-anomeric form of sialic acid is the minimal receptor determinant recognized by reovirus.
Virology 1989;172(1):382-5.
1989: M C Yeung; D Lim; R Duncan; M S Shahrabadi; L W Cashdollar; Patrick W K Lee
The cell attachment proteins of type 1 and type 3 reovirus are differentially susceptible to trypsin and chymotrypsin.
Virology 1989;170(1):62-70.
1988: A H Choi; Patrick W K Lee
Does the beta-adrenergic receptor function as a reovirus receptor?
Virology 1988;163(1):191-7.
1988: M S Shahrabadi; Patrick W K Lee
Calcium requirement for syncytium formation in HEp-2 cells by respiratory syncytial virus.
Journal of clinical microbiology 1988;26(1):139-41.
1987: G Y Minuk; N Rascanin; R W Paul; Patrick W K Lee; K Buchan; J K Kelly
Reovirus type 3 infection in patients with primary biliary cirrhosis and primary sclerosing cholangitis.
Journal of hepatology 1987;5(1):8-13.
1987: M C Yeung; M J Gill; S S Alibhai; M S Shahrabadi; Patrick W K Lee
Purification and characterization of the reovirus cell attachment protein sigma 1.
Virology 1987;156(2):377-85.
1982: L W Cashdollar; J Esparza; G R Hudson; R Chmelo; Patrick W K Lee; W K Joklik
Cloning the double-stranded RNA genes of reovirus: sequence of the cloned S2 gene.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(24):7644-8.