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Stephen Lee

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TOP 3
Mathieu D Jacob; Timothy E Audas; Sahra-Taylor Mullineux; Stephen Lee
Where no RNA polymerase has gone before: novel functional transcripts derived from the ribosomal intergenic spacer.
James Uniacke; Arnim Pause; Josianne Payette; Marc R Fabian; Aleksandra Franovic; Martin Holcik; Chet E Holterman; Mathieu D Jacob; Gabriel Lachance; Stephen Lee
An oxygen-regulated switch in the protein synthesis machinery.
Timothy E Audas; Mathieu D Jacob; Stephen Lee
The nucleolar detention pathway: A cellular strategy for regulating molecular networks.

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All Publications

2012: Mathieu D Jacob; Timothy E Audas; Sahra-Taylor Mullineux; Stephen Lee
Where no RNA polymerase has gone before: novel functional transcripts derived from the ribosomal intergenic spacer.
Nucleus (Austin, Tex.) 2012;3(4):315-9.
2012: James Uniacke; Arnim Pause; Josianne Payette; Marc R Fabian; Aleksandra Franovic; Martin Holcik; Chet E Holterman; Mathieu D Jacob; Gabriel Lachance; Stephen Lee
An oxygen-regulated switch in the protein synthesis machinery.
Nature 2012;486(7401):126-9.
2012: Timothy E Audas; Mathieu D Jacob; Stephen Lee
The nucleolar detention pathway: A cellular strategy for regulating molecular networks.
Cell cycle (Georgetown, Tex.) 2012;11(11):2059-62.
2012: Timothy E Audas; Mathieu D Jacob; Stephen Lee
Immobilization of proteins in the nucleolus by ribosomal intergenic spacer noncoding RNA.
Molecular cell 2012;45(2):147-57.
2010: Chet E Holterman; Aleksandra Franovic; Josianne Payette; Stephen Lee
ETS-1 oncogenic activity mediated by transforming growth factor alpha.
Cancer research 2010;70(2):730-40.
2009: Aleksandra Franovic; Chet E Holterman; Josianne Payette; Stephen Lee
Human cancers converge at the HIF-2alpha oncogenic axis.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(50):21306-11.
2009: Mireille Khacho; Stephen Lee
Subcellular dynamics of the VHL tumor suppressor: on the move for HIF degradation.
Future oncology (London, England) 2009;5(1):85-95.
2008: Mireille Khacho; Karim Mekhail; Karine Pilon-Larose; Arnim Pause; Jocelyn Côté; Stephen Lee
eEF1A is a novel component of the mammalian nuclear protein export machinery.
Molecular biology of the cell 2008;19(12):5296-308.
2008: Mireille Khacho; Karim Mekhail; Karine Pilon-Larose; Josianne Payette; Stephen Lee
Cancer-causing mutations in a novel transcription-dependent nuclear export motif of VHL abrogate oxygen-dependent degradation of hypoxia-inducible factor.
Molecular and cellular biology 2008;28(1):302-14.
2007: Karim Mekhail; Luis Rivero-Lopez; Ahmad Al-Masri; Caroline Brandon; Mireille Khacho; Stephen Lee
Identification of a common subnuclear localization signal.
Molecular biology of the cell 2007;18(10):3966-77.
2007: Aleksandra Franovic; Lakshman Gunaratnam; Karlene Smith; Isabelle Robert; David Patten; Stephen Lee
Translational up-regulation of the EGFR by tumor hypoxia provides a nonmutational explanation for its overexpression in human cancer.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(32):13092-7.
2006: Karim Mekhail; Luis Rivero-Lopez; Mireille Khacho; Stephen Lee
Restriction of rRNA synthesis by VHL maintains energy equilibrium under hypoxia.
Cell cycle (Georgetown, Tex.) 2006;5(20):2401-13.
2006: Aleksandra Franovic; Isabelle Robert; Karlene Smith; Ghada Kurban; Arnim Pause; Lakshman Gunaratnam; Stephen Lee
Multiple acquired renal carcinoma tumor capabilities abolished upon silencing of ADAM17.
Cancer research 2006;66(16):8083-90.
2005: Karim Mekhail; Mireille Khacho; Amanda Carrigan; Robert R J Hache; Lakshman Gunaratnam; Stephen Lee
Regulation of ubiquitin ligase dynamics by the nucleolus.
The Journal of cell biology 2005;170(5):733-44.
2005: Karlene Smith; Lakshman Gunaratnam; Melissa Morley; Aleksandra Franovic; Karim Mekhail; Stephen Lee
Silencing of epidermal growth factor receptor suppresses hypoxia-inducible factor-2-driven VHL-/- renal cancer.
Cancer research 2005;65(12):5221-30.
2004: Karim Mekhail; Mireille Khacho; Lakshman Gunaratnam; Stephen Lee
Oxygen sensing by H+: implications for HIF and hypoxic cell memory.
Cell cycle (Georgetown, Tex.) 2004;3(8):1027-9.
2004: Karim Mekhail; Lakshman Gunaratnam; Marie-Eve Bonicalzi; Stephen Lee
HIF activation by pH-dependent nucleolar sequestration of VHL.
Nature cell biology 2004;6(7):642-7.
2003: Lakshman Gunaratnam; Melissa Morley; Aleksandra Franovic; Natalie de Paulsen; Karim Mekhail; Doris A E Parolin; Eijiro Nakamura; Ian A J Lorimer; Stephen Lee
Hypoxia inducible factor activates the transforming growth factor-alpha/epidermal growth factor receptor growth stimulatory pathway in VHL(-/-) renal cell carcinoma cells.
The Journal of biological chemistry 2003;278(45):44966-74.
2002: Isabelle Groulx; Stephen Lee
Oxygen-dependent ubiquitination and degradation of hypoxia-inducible factor requires nuclear-cytoplasmic trafficking of the von Hippel-Lindau tumor suppressor protein.
Molecular and cellular biology 2002;22(15):5319-36.
2001: N de Paulsen; A Brychzy; MC Fournier; Richard D Klausner; JR Gnarra; Arnim Pause; Stephen Lee
Role of transforming growth factor-alpha in von Hippel--Lindau (VHL)(-/-) clear cell renal carcinoma cell proliferation: a possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesis.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(4):1387-92.
2001: Marie-Eve Bonicalzi; Isabelle Groulx; Stephen Lee
Role of exon 2-encoded beta -domain of the von Hippel-Lindau tumor suppressor protein.
The Journal of biological chemistry 2001;276(2):1407-16.
2000: Isabelle Groulx; Marie-Eve Bonicalzi; Stephen Lee
Ran-mediated nuclear export of the von Hippel-Lindau tumor suppressor protein occurs independently of its assembly with cullin-2.
The Journal of biological chemistry 2000;275(12):8991-9000.