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Virginia M-Y Lee

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Alex Crowe; Michael J James; Virginia M-Y Lee; Amos B Smith; John Q Trojanowski; Carlo Ballatore; Kurt R Brunden
Aminothienopyridazines and methylene blue affect Tau fibrillization via cysteine oxidation.
David J Irwin; Virginia M-Y Lee; Ellen Werber Leschek; James L Mills; Lawrence B Schonberger; Joseph Y Abrams; John Q Trojanowski
Evaluation of potential infectivity of Alzheimer and Parkinson disease proteins in recipients of cadaver-derived human growth hormone.
Jing L Guo; Virginia M-Y Lee
Neurofibrillary tangle-like tau pathology induced by synthetic tau fibrils in primary neurons over-expressing mutant tau.

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All Publications

2013: Alex Crowe; Michael J James; Virginia M-Y Lee; Amos B Smith; John Q Trojanowski; Carlo Ballatore; Kurt R Brunden
Aminothienopyridazines and methylene blue affect Tau fibrillization via cysteine oxidation.
The Journal of biological chemistry 2013;288(16):11024-37.
2013: David J Irwin; Virginia M-Y Lee; Ellen Werber Leschek; James L Mills; Lawrence B Schonberger; Joseph Y Abrams; John Q Trojanowski
Evaluation of potential infectivity of Alzheimer and Parkinson disease proteins in recipients of cadaver-derived human growth hormone.
JAMA neurology 2013;70(4):462-8.
2013: Jing L Guo; Virginia M-Y Lee
Neurofibrillary tangle-like tau pathology induced by synthetic tau fibrils in primary neurons over-expressing mutant tau.
FEBS letters 2013;587(6):717-23.
2013: David J Irwin; Virginia M-Y Lee; David J Libon; Leo F McCluskey; Corey T McMillan; John Powers; Katya Rascovsky; Leslie M Shaw; Jon B Toledo; John Q Trojanowski; Vivianna M Van Deerlin; David A Wolk; John H Woo; Elisabeth McCarty Wood; Steven E Arnold; Jonathan Bekisz; Ashley Boller; Johannes Brettschneider; Keerthi Chandrasekaran; Philip A Cook; Lauren B Elman; Murray Grossman
Cognitive decline and reduced survival in C9orf72 expansion frontotemporal degeneration and amyotrophic lateral sclerosis.
Journal of neurology, neurosurgery, and psychiatry 2013;84(2):163-9.
2013: Michiyo Iba; Jennifer D McBride; John Q Trojanowski; Bin Zhang; Jing L Guo; Virginia M-Y Lee
Synthetic tau fibrils mediate transmission of neurofibrillary tangles in a transgenic mouse model of Alzheimer's-like tauopathy.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013;33(3):1024-37.
2013: Mitchel A Kling; Virginia M-Y Lee; John Q Trojanowski; David A Wolk; Steven E Arnold
Vascular disease and dementias: paradigm shifts to drive research in new directions.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2013;9(1):76-92.
2013: John L Robinson; Anna Stieber; Felix Geser; Linda K Kwong; Virginia M-Y Lee; Mfon Umoh; Vivianna M Van Deerlin; John Q Trojanowski
TDP-43 skeins show properties of amyloid in a subset of ALS cases.
Acta neuropathologica 2013;125(1):121-31.
2012: Mark Yarchoan; Mitchel A Kling; Edward B Lee; Virginia M-Y Lee; Jon B Toledo; John Q Trojanowski; Vivianna M Van Deerlin; David A Wolk; Sharon X Xie; Steven E Arnold
Cerebrovascular atherosclerosis correlates with Alzheimer pathology in neurodegenerative dementias.
Brain : a journal of neurology 2012;135(Pt 12):3749-56.
2012: James H Soper; Shimpei Sugiyama; John Q Trojanowski; Xiaozhao Wang; Katie Herbst-Robinson; Michael J James; Virginia M-Y Lee; Amos B Smith; Carlo Ballatore; Kurt R Brunden
Brain-penetrant tetrahydronaphthalene thromboxane A2-prostanoid (TP) receptor antagonists as prototype therapeutics for Alzheimer's disease.
ACS chemical neuroscience 2012;3(11):928-40.
2012: Kelvin Luk; Patrick O'Brien; John Q Trojanowski; Bin Zhang; Jenna Carroll; Victoria Kehm; Virginia M-Y Lee
Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice.
Science (New York, N.Y.) 2012;338(6109):949-53.
2012: Carlo Ballatore; Kurt R Brunden; Donna M Huryn; Virginia M-Y Lee; John Q Trojanowski; Amos B Smith
Microtubule stabilizing agents as potential treatment for Alzheimer's disease and related neurodegenerative tauopathies.
Journal of medicinal chemistry 2012;55(21):8979-96.
2012: John Q Trojanowski; Mary Naylor; Steven E Arnold; Kurt R Brunden; Jason H Karlawish; Virginia M-Y Lee
A model for improving the treatment and care of Alzheimer's disease patients through interdisciplinary research.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2012;8(6):564-73.
2012: Jon B Toledo; John Q Trojanowski; Michael W Weiner; Clifford R Jack; William Jagust; Virginia M-Y Lee; Leslie M Shaw; Estefanía Toledo
Cardiovascular risk factors, cortisol, and amyloid-β deposition in Alzheimer's Disease Neuroimaging Initiative.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2012;8(6):483-9.
2012: David J Irwin; Virginia M-Y Lee; James B Leverenz; Thomas J Montine; John L Robinson; Jon B Toledo; John E Duda; Howard I Hurtig; Vivianna M Van Deerlin; Matthew T White; Sharon X Xie; John Q Trojanowski
Neuropathologic substrates of Parkinson disease dementia.
Annals of neurology 2012;72(4):587-98.
2012: William T Hu; Howard I Hurtig; Jason Karlawish; Max Kuhn; Virginia M-Y Lee; Leo McCluskey; John C Morris; Richard Perrin; Eve Pickering; Leslie M Shaw; Andrew Siderowf; Holly Soares; Frank Swenson; John Q Trojanowski; Vivianna M Van Deerlin; Chengjie Xiong; Steven E Arnold; Yu Chen; Alice Chen-Plotkin; Christopher M Clark; Rebecca Craig-Schapiro; Lauren B Elman; Anne M Fagan; Murray Grossman; David M Holtzman
Plasma multianalyte profiling in mild cognitive impairment and Alzheimer disease.
Neurology 2012;79(9):897-905.
2012: Alice S Chen-Plotkin; Michael D Gallagher; Murray Grossman; Linda K Kwong; John Q Trojanowski; Travis L Unger; Vivianna M Van Deerlin; Laura Volpicelli-Daley; Sebastian Akle; Emily Bill; Johanna I Busch; Virginia M-Y Lee
TMEM106B, the risk gene for frontotemporal dementia, is regulated by the microRNA-132/212 cluster and affects progranulin pathways.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(33):11213-27.
2012: Kurt R Brunden; Virginia M-Y Lee; Amos B Smith; Carlo Ballatore; John Q Trojanowski
Brain-penetrant microtubule-stabilizing compounds as potential therapeutic agents for tauopathies.
Biochemical Society transactions 2012;40(4):661-6.
2012: Michael P Hart; Virginia M-Y Lee; John Q Trojanowski; Johannes Brettschneider; Aaron D Gitler
Distinct TDP-43 pathology in ALS patients with ataxin 2 intermediate-length polyQ expansions.
Acta neuropathologica 2012;124(2):221-30.
2012: David J Irwin; Virginia M-Y Lee; Corey T McMillan; Leslie M Shaw; Jon B Toledo; John Q Trojanowski; Vivianna M Van Deerlin; Li-San Wang; Steven E Arnold; Murray Grossman
Comparison of cerebrospinal fluid levels of tau and Aβ 1-42 in Alzheimer disease and frontotemporal degeneration using 2 analytical platforms.
Archives of neurology 2012;69(8):1018-25.
2012: Maria Martinez-Lage; Leo McCluskey; Laura Molina-Porcel; Dana Falcone; Virginia M-Y Lee; Vivianna M Van Deerlin; John Q Trojanowski
TDP-43 pathology in a case of hereditary spastic paraplegia with a NIPA1/SPG6 mutation.
Acta neuropathologica 2012;124(2):285-91.
2012: Carlo Ballatore; Kurt R Brunden; Alex Crowe; Michael James; Virginia M-Y Lee; Kevin Lou; Francesco Piscitelli; Gabrielle Rossidivito; John Q Trojanowski; Yuemang Yao; Amos B Smith
Aminothienopyridazine inhibitors of tau aggregation: evaluation of structure-activity relationship leads to selection of candidates with desirable in vivo properties.
Bioorganic & medicinal chemistry 2012;20(14):4451-61.
2012: Michal J Figurski; Magdalena Korecka; Virginia M-Y Lee; Leslie M Shaw; Jon Toledo; John Q Trojanowski; hugo vanderstichele; Teresa Waligórska
Improved protocol for measurement of plasma β-amyloid in longitudinal evaluation of Alzheimer's Disease Neuroimaging Initiative study patients.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2012;8(4):250-60.
2012: Jon B Toledo; Sharon X Xie; Steven E Arnold; Johannes Brettschneider; Murray Grossman; William T Hu; Virginia M-Y Lee; Leslie M Shaw; John Q Trojanowski
CSF biomarkers cutoffs: the importance of coincident neuropathological diseases.
Acta neuropathologica 2012;124(1):23-35.
2012: Julien Couthouis; Zamia Diaz; Lauren Elman; Renske Erion; Edward C Frackelton; Ian P Blair; Nancy M Bonini; Dana Clay-Falcone; Robert Greene; Hakon Hakonarson; Michael P Hart; Fadia Ibrahim; Robert G Kalb; Cecilia E Kim; Hyung-Jun Kim; Oliver D King; Virginia M-Y Lee; Leo McCluskey; Jelena Mojsilovic-Petrovic; Zissimos Mourelatos; Tadashi Nakaya; Garth A Nicholson; Saarene Panossian; James Shorter; Jennifer A Solski; John Q Trojanowski; Vivianna M Van Deerlin; Kelly L Williams; Aaron D Gitler
Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis.
Human molecular genetics 2012;21(13):2899-911.
2012: Johannes Brettschneider; Lauren B Elman; Murray Grossman; David J Irwin; Linda K Kwong; Edward B Lee; Virginia M-Y Lee; Leo McCluskey; Laura Molina-Porcel; Mervyn Monteiro; John L Robinson; Nathaniel Safren; Jon B Toledo; Yousuf O Ali; Vivianna M Van Deerlin; John Q Trojanowski
Pattern of ubiquilin pathology in ALS and FTLD indicates presence of C9ORF72 hexanucleotide expansion.
Acta neuropathologica 2012;123(6):825-39.
2012: David E Hurtado; Awo K Aboagye; Jenna C Carroll; Caryn Macdonald; Laura Molina-Porcel; John Q Trojanowski; Virginia M-Y Lee
Selectively silencing GSK-3 isoforms reduces plaques and tangles in mouse models of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(21):7392-402.
2012: Kelvin Luk; Patrick O'Brien; John Q Trojanowski; Bin Zhang; Victoria M Kehm; Virginia M-Y Lee
Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice.
The Journal of experimental medicine 2012;209(5):975-86.
2012: Bin Zhang; Carlo Ballatore; Jenna Carroll; Anne-Marie L Hogan; Michiyo Iba; Virginia M-Y Lee; Justin S Potuzak; Amos B Smith; John Q Trojanowski; Sharon X Xie; Yuemang Yao; Kurt R Brunden
The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(11):3601-11.
2012: Todd J Cohen; Andrew W Hwang; John Q Trojanowski; Travis Unger; Virginia M-Y Lee
Redox signalling directly regulates TDP-43 via cysteine oxidation and disulphide cross-linking.
The EMBO journal 2012;31(5):1241-52.
2012: David J Irwin; Virginia M-Y Lee; Steven E Arnold; Todd J Cohen; Murray Grossman; Sharon X Xie; John Q Trojanowski
Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies.
Brain : a journal of neurology 2012;135(Pt 3):807-18.
2012: Johannes Brettschneider; Lauren B Elman; Felix Geser; Murray Grossman; Virginia M-Y Lee; David J Libon; Leo McCluskey; Jon B Toledo; Sharon X Xie; John Q Trojanowski
Microglial activation and TDP-43 pathology correlate with executive dysfunction in amyotrophic lateral sclerosis.
Acta neuropathologica 2012;123(3):395-407.
2012: Yu Wang; Hui Yang; Cyrus Zabetian; Daniela Berg; Kevin C Cain; Kathryn A Chung; Douglas Galasko; David S Goldstein; Masato Hasegawa; Howard Hurtig; Poul Henning Jensen; Virginia M-Y Lee; James B Leverenz; Lin Xiangmin; Irene Litvan; Masami Masuda; Catherine Pan; Elaine Peskind; Mya C Schiess; Min Shi; Andrew D Siderowf; Karin Srulijes; John Q Trojanowski; Jing Zhang
Phosphorylated α-synuclein in Parkinson's disease.
Science translational medicine 2012;4(121):121ra20.
2012: Johannes Brettschneider; Lauren B Elman; Virginia M-Y Lee; Leo McCluskey; Jon B Toledo; Vivianna M Van Deerlin; John Q Trojanowski
Microglial activation correlates with disease progression and upper motor neuron clinical symptoms in amyotrophic lateral sclerosis.
PloS one 2012;7(6):e39216.
2012: Li-San Wang; Young Baek; Shu-Kai Chang; Malgorzata Knapik-Czajka; Virginia M-Y Lee; Susan Leight; Yuk Yee Leung; Leslie M Shaw; John Q Trojanowski; Christopher M Clark
Comparison of xMAP and ELISA assays for detecting cerebrospinal fluid biomarkers of Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2012;31(2):439-45.
2011: Todd J Cohen; Virginia M-Y Lee; John Q Trojanowski
TDP-43 functions and pathogenic mechanisms implicated in TDP-43 proteinopathies.
Trends in molecular medicine 2011;17(11):659-67.
2011: Carlo Ballatore; Kurt R Brunden; Longchuan Huang; Donna M Huryn; Michael James; Virginia M-Y Lee; Francesco Piscitelli; James H Soper; John Q Trojanowski; Onur Atasoylu; Amos B Smith
Cyclopentane-1,3-dione: a novel isostere for the carboxylic acid functional group. Application to the design of potent thromboxane (A2) receptor antagonists.
Journal of medicinal chemistry 2011;54(19):6969-83.
2011: Laura A Volpicelli-Daley; Kelvin C Luk; David F Meaney; Tapan P Patel; Dawn M Riddle; Anna Stieber; Selcuk A Tanik; John Q Trojanowski; Virginia M-Y Lee
Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death.
Neuron 2011;72(1):57-71.
2011: Jenna C Carroll; Michiyo Iba; Michael J James; Virginia M-Y Lee; Debra A Bangasser; Kurt R Brunden; Rita J Valentino; John Q Trojanowski
Chronic stress exacerbates tau pathology, neurodegeneration, and cognitive performance through a corticotropin-releasing factor receptor-dependent mechanism in a transgenic mouse model of tauopathy.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(40):14436-49.
2011: Jon B Toledo; John Q Trojanowski; hugo vanderstichele; Michael W Weiner; Sharon X Xie; Paul S Aisen; Charles DeCarli; Michal Figurski; Clifford R Jack; William Jagust; Virginia M-Y Lee; Ronald C. Petersen; Leslie M Shaw; Arthur W Toga; Estefanía Toledo
Factors affecting Aβ plasma levels and their utility as biomarkers in ADNI.
Acta neuropathologica 2011;122(4):401-13.
2011: Kaoru Yamada; Lester I Binder; John R Cirrito; Marc I Diamond; Mary Beth Finn; Brandon Holmes; Hong Jiang; Virginia M-Y Lee; Eva-Maria Mandelkow; Floy R Stewart; David M Holtzman
In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(37):13110-7.
2011: Youngshin Lim; James H Soper; John Q Trojanowski; Victoria M Kehm; Edward B Lee; Chi Li; Virginia M-Y Lee
α-Syn suppression reverses synaptic and memory defects in a mouse model of dementia with Lewy bodies.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(27):10076-87.
2011: Sharon X Xie; Vivianna M Van Deerlin; Steven E Arnold; Young Baek; Lauren B Elman; Murray Grossman; Howard I Hurtig; Jason Karlawish; Virginia M-Y Lee; Leo McCluskey; Andrew Siderowf; John Q Trojanowski
Building an integrated neurodegenerative disease database at an academic health center.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2011;7(4):e84-93.
2011: Ian R A Mackenzie; David M A Mann; Manuela Neumann; Robert H Perry; Deepak M Sampathu; John Q Trojanowski; Atik Baborie; Daniel Du Plessis; Evelyn Jaros; Virginia M-Y Lee
A harmonized classification system for FTLD-TDP pathology.
Acta neuropathologica 2011;122(1):111-3.
2011: G Scott Pesiridis; Kalyan Tripathy; Selçuk Tanik; John Q Trojanowski; Virginia M-Y Lee
A "two-hit" hypothesis for inclusion formation by carboxyl-terminal fragments of TDP-43 protein linked to RNA depletion and impaired microtubule-dependent transport.
The Journal of biological chemistry 2011;286(21):18845-55.
2011: Matthew J Winton; Edward B Lee; Eveline Sun; Margaret M Wong; Susan Leight; Bin Zhang; John Q Trojanowski; Virginia M-Y Lee
Intraneuronal APP, not free Aβ peptides in 3xTg-AD mice: implications for tau versus Aβ-mediated Alzheimer neurodegeneration.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(21):7691-9.
2011: Nobumasa Takasugi; Taisuke Tomita; John Q Trojanowski; Satoshi Yokoshima; Tohru Fukuyama; Takuya Higo; Yukiko Hori; Hayato Isshiki; Virginia M-Y Lee; Satoko Osawa; Tomoki Sasaki; Naoaki Shimada; Kunimichi Suzuki; Takeshi Iwatsubo
BACE1 activity is modulated by cell-associated sphingosine-1-phosphate.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(18):6850-7.
2011: Leslie M Shaw; Eric Siemers; Adam J Simon; Holly Soares; John Q Trojanowski; hugo vanderstichele; Kaj Blennow; Els Coart; Robert A Dean; Michal Figurski; Malgorzata Knapik-Czajka; Virginia M-Y Lee; Piotr Lewczuk; William Potter
Qualification of the analytical and clinical performance of CSF biomarker analyses in ADNI.
Acta neuropathologica 2011;121(5):597-609.
2011: Jing L Guo; Virginia M-Y Lee
Seeding of normal Tau by pathological Tau conformers drives pathogenesis of Alzheimer-like tangles.
The Journal of biological chemistry 2011;286(17):15317-31.
2011: Alice S Chen-Plotkin; William T Hu; Andrew Siderowf; Daniel Weintraub; Rachel Goldmann Gross; Howard I Hurtig; Sharon X Xie; Steven E Arnold; Murray Grossman; Christopher M Clark; Leslie M Shaw; Leo McCluskey; Lauren Elman; Vivianna M Van Deerlin; Virginia M-Y Lee; Holly Soares; John Q Trojanowski
Plasma epidermal growth factor levels predict cognitive decline in Parkinson disease.
Annals of neurology 2011;69(4):655-63.
2011: Alice S Chen-Plotkin; Maria Martinez-Lage; Patrick M A Sleiman; William Hu; Robert Greene; Elisabeth McCarty Wood; Shaoxu Bing; Murray Grossman; Gerard D Schellenberg; Kimmo J Hatanpaa; Myron F Weiner; Charles L White; William S Brooks; Glenda M Halliday; Jillian J Kril; Marla Gearing; Thomas Beach; Neill R Graff-Radford; dennis dickson; Rosa Rademakers; Bradley F Boeve; Stuart M Pickering-Brown; Julie Snowden; John C van Swieten; Peter Heutink; Harro Seelaar; Jill R Murrell; Bernardino Ghetti; Salvatore Spina; Jordan Grafman; Jeffrey A Kaye; Randall L Woltjer; Marsel Mesulam; Eileen Bigio; Albert Lladó; Bruce L Miller; Ainhoa Alzualde; Fermin Moreno; Jonathan D Rohrer; Ian R A Mackenzie; Howard H Feldman; Ronald L Hamilton; Marc Cruts; Sebastiaan Engelborghs; Peter P De Deyn; Christine Van Broeckhoven; Thomas D Bird; Nigel J Cairns; Alison Goate; Matthew P Frosch; Peter F Riederer; Nenad Bogdanovic; Virginia M-Y Lee; John Q Trojanowski; Vivianna M Van Deerlin
Genetic and clinical features of progranulin-associated frontotemporal lobar degeneration.
Archives of neurology 2011;68(4):488-97.
2011: Felix Geser; Beth Stein; Michael Partain; Lauren B Elman; Leo McCluskey; Sharon X Xie; Vivianna M Van Deerlin; Linda K Kwong; Virginia M-Y Lee; John Q Trojanowski
Motor neuron disease clinically limited to the lower motor neuron is a diffuse TDP-43 proteinopathy.
Acta neuropathologica 2011;121(4):509-17.
2011: Kurt R Brunden; Yuemang Yao; Justin S Potuzak; Nuria Ibarz Ferrer; Carlo Ballatore; Michael J James; Anne-Marie L Hogan; John Q Trojanowski; Amos B Smith; Virginia M-Y Lee
The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer's disease and related tauopathies.
Pharmacological research : the official journal of the Italian Pharmacological Society 2011;63(4):341-51.
2011: Jun Maeda; Ming-Rong Zhang; Takashi Okauchi; Bin Ji; Maiko Ono; Satoko Hattori; Katsushi Kumata; Nobuhisa Iwata; Takaomi C Saido; John Q Trojanowski; Virginia M-Y Lee; Matthias Staufenbiel; Takami Tomiyama; Hiroshi Mori; Toshimitsu Fukumura; Tetsuya Suhara; Makoto Higuchi
In vivo positron emission tomographic imaging of glial responses to amyloid-beta and tau pathologies in mouse models of Alzheimer's disease and related disorders.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(12):4720-30.
2011: Ryan Vass; Emily Ashbridge; Felix Geser; William T Hu; Murray Grossman; Dana Clay-Falcone; Lauren B Elman; Leo McCluskey; Virginia M-Y Lee; Vivianna M Van Deerlin; John Q Trojanowski; Alice S Chen-Plotkin
Risk genotypes at TMEM106B are associated with cognitive impairment in amyotrophic lateral sclerosis.
Acta neuropathologica 2011;121(3):373-80.
2011: James H Soper; Victoria Kehm; Christopher G Burd; Vytas A Bankaitis; Virginia M-Y Lee
Aggregation of α-synuclein in S. cerevisiae is associated with defects in endosomal trafficking and phospholipid biosynthesis.
Journal of molecular neuroscience : MN 2011;43(3):391-405.
2011: Lionel M Igaz; Linda K Kwong; Edward B Lee; Alice Chen-Plotkin; Eric Swanson; Travis Unger; Joe Malunda; Yan Xu; Matthew J Winton; John Q Trojanowski; Virginia M-Y Lee
Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice.
The Journal of clinical investigation 2011;121(2):726-38.
2011: Hiroki Takeuchi; John Q Trojanowski; Kayoko Tsukita; Keizo Takao; Makoto Higuchi; Michiyo Iba; Haruhisa Inoue; Yumiko Iwamoto; Yoshiko Karatsu; Virginia M-Y Lee; Tsuyoshi Miyakawa; Tetsuya Suhara; Ryosuke Takahashi
P301S mutant human tau transgenic mice manifest early symptoms of human tauopathies with dementia and altered sensorimotor gating.
PloS one 2011;6(6):e21050.
2011: Zhenming Yu; Yongqing Zhu; Alice S Chen-Plotkin; Dana Clay-Falcone; Leo McCluskey; Lauren B Elman; Robert G Kalb; John Q Trojanowski; Virginia M-Y Lee; Vivianna M Van Deerlin; Aaron D Gitler; Nancy M Bonini
PolyQ repeat expansions in ATXN2 associated with ALS are CAA interrupted repeats.
PloS one 2011;6(3):e17951.
2011: Todd J Cohen; Jing L Guo; David E Hurtado; Linda K Kwong; Ian P Mills; John Q Trojanowski; Virginia M-Y Lee
The acetylation of tau inhibits its function and promotes pathological tau aggregation.
Nature communications 2011;2():252.
2011: L Lin; Virginia M-Y Lee; Y Wang; J S Lin; E Sock; M Wegner; L Lei
Sox11 regulates survival and axonal growth of embryonic sensory neurons.
Developmental dynamics : an official publication of the American Association of Anatomists 2011;240(1):52-64.
2010: Kurt R Brunden; Bin Zhang; Jenna Carroll; Yuemang Yao; Justin S Potuzak; Anne-Marie L Hogan; Michiyo Iba; Michael J James; Sharon X Xie; Carlo Ballatore; Amos B Smith; Virginia M-Y Lee; John Q Trojanowski
Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(41):13861-6.
2010: Felix Geser; John L Robinson; Joseph A Malunda; Sharon X Xie; Chris M Clark; Linda K Kwong; Paul J Moberg; Erika M Moore; Vivianna M Van Deerlin; Virginia M-Y Lee; Steven E Arnold; John Q Trojanowski
Pathological 43-kDa transactivation response DNA-binding protein in older adults with and without severe mental illness.
Archives of neurology 2010;67(10):1238-50.
2010: David E Hurtado; Laura Molina-Porcel; Michiyo Iba; Awo K Aboagye; Steven M Paul; John Q Trojanowski; Virginia M-Y Lee
A{beta} accelerates the spatiotemporal progression of tau pathology and augments tau amyloidosis in an Alzheimer mouse model.
The American journal of pathology 2010;177(4):1977-88.
2010: William T Hu; Alice Chen-Plotkin; Steven E Arnold; Murray Grossman; Christopher M Clark; Leslie M Shaw; Leo McCluskey; Lauren Elman; Jason Karlawish; Howard I Hurtig; Andrew Siderowf; Virginia M-Y Lee; Holly Soares; John Q Trojanowski
Biomarker discovery for Alzheimer's disease, frontotemporal lobar degeneration, and Parkinson's disease.
Acta neuropathologica 2010;120(3):385-99.
2010: Andrew C Elden; Hyung-Jun Kim; Michael P Hart; Alice S Chen-Plotkin; Brian S Johnson; Xiaodong Fang; Maria Armakola; Felix Geser; Robert Greene; Min Min Lu; Arun Padmanabhan; Dana Clay-Falcone; Leo McCluskey; Lauren Elman; Denise Juhr; Peter J Gruber; Udo Rüb; Georg Auburger; John Q Trojanowski; Virginia M-Y Lee; Vivianna M Van Deerlin; Nancy M Bonini; Aaron D Gitler
Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS.
Nature 2010;466(7310):1069-75.
2010: Magdalena Korecka; Christopher M Clark; Virginia M-Y Lee; John Q Trojanowski; Leslie M Shaw
Simultaneous HPLC-MS-MS quantification of 8-iso-PGF(2alpha) and 8,12-iso-iPF(2alpha) in CSF and brain tissue samples with on-line cleanup.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2010;878(24):2209-16.
2010: Gillian P Ritson; Sara K Custer; Brian D Freibaum; Jake B Guinto; Dyanna Geffel; Jennifer Moore; Waixing Tang; Matthew J Winton; Manuela Neumann; John Q Trojanowski; Virginia M-Y Lee; Mark S Forman; J. Paul Taylor
TDP-43 mediates degeneration in a novel Drosophila model of disease caused by mutations in VCP/p97.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(22):7729-39.
2010: William T Hu; Alice Chen-Plotkin; Steven E Arnold; Murray Grossman; Christopher M Clark; Leslie M Shaw; Eve Pickering; Max Kuhn; Yu Chen; Leo McCluskey; Lauren Elman; Jason Karlawish; Howard I Hurtig; Andrew Siderowf; Virginia M-Y Lee; Holly Soares; John Q Trojanowski
Novel CSF biomarkers for Alzheimer's disease and mild cognitive impairment.
Acta neuropathologica 2010;119(6):669-78.
2010: Kurt R Brunden; Carlo Ballatore; Alex Crowe; Amos B Smith; Virginia M-Y Lee; John Q Trojanowski
Tau-directed drug discovery for Alzheimer's disease and related tauopathies: a focus on tau assembly inhibitors.
Experimental neurology 2010;223(2):304-10.
2010: Carlo Ballatore; Kurt R Brunden; Francesco Piscitelli; Michael J James; Alex Crowe; Yuemang Yao; Edward Hyde; John Q Trojanowski; Virginia M-Y Lee; Amos B Smith
Discovery of brain-penetrant, orally bioavailable aminothienopyridazine inhibitors of tau aggregation.
Journal of medicinal chemistry 2010;53(9):3739-47.
2010: John Q Trojanowski; Hugo Vandeerstichele; Magdalena Korecka; Christopher M Clark; Paul S Aisen; Ronald C. Petersen; Kaj Blennow; Holly Soares; Adam Simon; Piotr Lewczuk; Robert Dean; Eric Siemers; William Z Potter; Michael Weiner; Clifford R Jack; William J Jagust; Arthur W Toga; Virginia M-Y Lee; Leslie M Shaw
Update on the biomarker core of the Alzheimer's Disease Neuroimaging Initiative subjects.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2010;6(3):230-8.
2010: James Y Garbern; Manuela Neumann; John Q Trojanowski; Virginia M-Y Lee; Gerald L Feldman; Joy W Norris; Michael J Friez; Charles E Schwartz; Roger Stevenson; Anders A F Sima
A mutation affecting the sodium/proton exchanger, SLC9A6, causes mental retardation with tau deposition.
Brain : a journal of neurology 2010;133(Pt 5):1391-402.
2010: Kunihiro Uryu; Terri Haddix; John Robinson; Hanae Nakashima-Yasuda; Virginia M-Y Lee; John Q Trojanowski
Burden of neurodegenerative diseases in a cohort of medical examiner subjects.
Journal of forensic sciences 2010;55(3):642-5.
2010: Steven E Arnold; Edward B Lee; Paul Moberg; Lauren Stutzbach; Hala Kazi; Li-Ying Han; Virginia M-Y Lee; John Q Trojanowski
Olfactory epithelium amyloid-beta and paired helical filament-tau pathology in Alzheimer disease.
Annals of neurology 2010;67(4):462-9.
2010: Alice S Chen-Plotkin; Virginia M-Y Lee; John Q Trojanowski
TAR DNA-binding protein 43 in neurodegenerative disease.
Nature reviews. Neurology 2010;6(4):211-20.
2010: Brian C Kraemer; Theresa Schuck; Jeanna M Wheeler; Linda C Robinson; John Q Trojanowski; Virginia M-Y Lee; Gerard D Schellenberg
Loss of murine TDP-43 disrupts motor function and plays an essential role in embryogenesis.
Acta neuropathologica 2010;119(4):409-19.
2010: Felix Geser; Virginia M-Y Lee; John Q Trojanowski
Amyotrophic lateral sclerosis and frontotemporal lobar degeneration: a spectrum of TDP-43 proteinopathies.
Neuropathology : official journal of the Japanese Society of Neuropathology 2010;30(2):103-12.
2010: John Q Trojanowski; Steven E Arnold; Jason H Karlawish; Kurt Brunden; Mark Cary; Christos Davatzikos; John Detre; Glen Gaulton; Murray Grossman; Howard I Hurtig; Kathryn Jedrziewski; Leo McCluskey; Mary Naylor; Daniel Polsky; Gerard D Schellenberg; Andrew Siderowf; Leslie M Shaw; Vivianna Van Deerlin; Li-San Wang; Rachel Werner; Sharon X Xie; Virginia M-Y Lee
Design of comprehensive Alzheimer's disease centers to address unmet national needs.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2010;6(2):150-5.
2010: Shaohua Xu; Kurt R Brunden; John Q Trojanowski; Virginia M-Y Lee
Characterization of tau fibrillization in vitro.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2010;6(2):110-7.
2010: ZAVEN KHACHATURIAN; Deborah Barnes; Richard Einstein; Sterling Johnson; Virginia M-Y Lee; Allen D Roses; Mark A Sager; William R Shankle; Peter J Snyder; Ronald C. Petersen; Gerard D Schellenberg; John Q Trojanowski; Paul Aisen; Marilyn S Albert; John C S Breitner; Neil Buckholtz; Maria Carrillo; Steven Ferris; Barry D Greenberg; Michael Grundman; Ara S Khachaturian; Lewis H Kuller; Oscar L Lopez; Paul Maruff; Richard C Mohs; Marcelle Morrison-Bogorad; Creighton Phelps; Eric Reiman; Marwan Sabbagh; Mary Sano; Lon S Schneider; Eric Siemers; Pierre Tariot; Jacques Touchon; Bruno Vellas; Lisa J Bain
Developing a national strategy to prevent dementia: Leon Thal Symposium 2009.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2010;6(2):89-97.
2010: Vivianna M Van Deerlin; Patrick M A Sleiman; Maria Martinez-Lage; Alice Chen-Plotkin; Li-San Wang; Neill R Graff-Radford; dennis dickson; Rosa Rademakers; Bradley F Boeve; Murray Grossman; Steven E Arnold; D M A Mann; Stuart M Pickering-Brown; Harro Seelaar; Peter Heutink; John C van Swieten; Jill R Murrell; Bernardino Ghetti; Salvatore Spina; Jordan Grafman; John R Hodges; Maria Grazia Spillantini; Sid Gilman; Andrew P Lieberman; Jeffrey A Kaye; Randall L Woltjer; Eileen H Bigio; Marsel Mesulam; Safa Al-Sarraj; Claire Troakes; Roger N Rosenberg; Charles L White; Isidro Ferrer; Albert Lladó; Manuela Neumann; Hans A Kretzschmar; Christine Marie Hulette; Kathleen A Welsh-Bohmer; Bruce L Miller; Ainhoa Alzualde; Adolfo Lopez de Munain; Ann C McKee; Marla Gearing; Allan Levey; James J Lah; John Hardy; Jonathan D Rohrer; Tammaryn Lashley; Ian R A Mackenzie; Howard H Feldman; Ronald L Hamilton; Steven T DeKosky; Julie van der Zee; Samir Kumar-Singh; Christine Van Broeckhoven; Richard Mayeux; Jean Paul G Vonsattel; Juan C Troncoso; Jillian J Kril; John B J Kwok; Glenda M Halliday; Thomas D Bird; Paul Geoffrey Ince; Pamela J Shaw; Nigel J Cairns; John C Morris; Catriona Ann McLean; Charles DeCarli; William G Ellis; Stefanie H Freeman; Matthew P Frosch; John H Growdon; Daniel P Perl; Mary Sano; David A Bennett; Julie A Schneider; Thomas Beach; Eric Reiman; Bryan Woodruff; Jeffrey L Cummings; Harry V Vinters; Carol A Miller; Helena C Chui; Irina Alafuzoff; Päivi Hartikainen; Danielle Seilhean; Douglas Galasko; Eliezer Masliah; Carl W Cotman; M Teresa Tuñón; M Cristina Caballero Martínez; David G Munoz; Steven L Carroll; Daniel Marson; Peter F Riederer; Nenad Bogdanovic; Gerard D Schellenberg; Hakon Hakonarson; John Q Trojanowski; Virginia M-Y Lee
Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions.
Nature genetics 2010;42(3):234-9.
2010: Chang-En Yu; Thomas D Bird; Lynn M Bekris; Thomas J Montine; James B Leverenz; Ellen Steinbart; Nichole M Galloway; Howard Feldman; Randall L Woltjer; Carol A Miller; Elisabeth McCarty Wood; Murray Grossman; Leo McCluskey; Christopher M Clark; Manuela Neumann; Adrian Danek; Douglas Galasko; Steven E Arnold; Alice Chen-Plotkin; Anna Karydas; Bruce L Miller; John Q Trojanowski; Virginia M-Y Lee; Gerard D Schellenberg; Vivianna M Van Deerlin
The spectrum of mutations in progranulin: a collaborative study screening 545 cases of neurodegeneration.
Archives of neurology 2010;67(2):161-70.
2010: Youngshin Lim; Vicky M Kehm; Chi Li; John Q Trojanowski; Virginia M-Y Lee
Forebrain overexpression of alpha-synuclein leads to early postnatal hippocampal neuron loss and synaptic disruption.
Experimental neurology 2010;221(1):86-97.
2010: Alice S Chen-Plotkin; Jiping Xiao; Felix Geser; Maria Martinez-Lage; Murray Grossman; Travis Unger; Elisabeth M Wood; Vivianna M Van Deerlin; John Q Trojanowski; Virginia M-Y Lee
Brain progranulin expression in GRN-associated frontotemporal lobar degeneration.
Acta neuropathologica 2010;119(1):111-22.
2009: Carol F Lippa; Andrea L Rosso; Lauren D Stutzbach; Manuela Neumann; Virginia M-Y Lee; John Q Trojanowski
Transactive response DNA-binding protein 43 burden in familial Alzheimer disease and Down syndrome.
Archives of neurology 2009;66(12):1483-8.
2009: Kelvin Luk; Cheng Song; Patrick O'Brien; Anna Stieber; Jonathan R Branch; Kurt R Brunden; John Q Trojanowski; Virginia M-Y Lee
Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(47):20051-6.
2009: William T Hu; Harro Seelaar; Keith A Josephs; David S. Knopman; Bradley Boeve; Eric J Sorenson; Leo McCluskey; Lauren Elman; Helenius J Schelhaas; Joseph E Parisi; Benno Kuesters; Virginia M-Y Lee; John Q Trojanowski; Ronald C. Petersen; John C van Swieten; Murray Grossman
Survival profiles of patients with frontotemporal dementia and motor neuron disease.
Archives of neurology 2009;66(11):1359-64.
2009: G Scott Pesiridis; Virginia M-Y Lee; John Q Trojanowski
Mutations in TDP-43 link glycine-rich domain functions to amyotrophic lateral sclerosis.
Human molecular genetics 2009;18(R2):R156-62.
2009: Kurt R Brunden; John Q Trojanowski; Virginia M-Y Lee
Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies.
Nature reviews. Drug discovery 2009;8(10):783-93.
2009: Alex Crowe; Wenwei Huang; Carlo Ballatore; Ronald L Johnson; Anne-Marie L Hogan; Ruili Huang; Jennifer Wichterman; Joshua McCoy; Donna Huryn; Douglas S Auld; Amos B Smith; James Inglese; John Q Trojanowski; Christopher P Austin; Kurt R Brunden; Virginia M-Y Lee
Identification of aminothienopyridazine inhibitors of tau assembly by quantitative high-throughput screening.
Biochemistry 2009;48(32):7732-45.
2009: Wenkai Li; Jeffrey B Sperry; Alex Crowe; John Q Trojanowski; Amos B Smith; Virginia M-Y Lee
Inhibition of tau fibrillization by oleocanthal via reaction with the amino groups of tau.
Journal of neurochemistry 2009;110(4):1339-51.
2009: Felix Geser; Maria Martinez-Lage; Linda K Kwong; Virginia M-Y Lee; John Q Trojanowski
Amyotrophic lateral sclerosis, frontotemporal dementia and beyond: the TDP-43 diseases.
Journal of neurology 2009;256(8):1205-14.
2009: Diana W Shineman; Aleksandra S Dain; Minkyu L Kim; Virginia M-Y Lee
Constitutively active Akt inhibits trafficking of amyloid precursor protein and amyloid precursor protein metabolites through feedback inhibition of phosphoinositide 3-kinase.
Biochemistry 2009;48(17):3787-94.
2009: Lentz Margaret; W K Kim; Virginia M-Y Lee; S Bazner; Elkan F Halpern; Nagagopal Venna; K Williams; E S Rosenberg; R Gilberto González
Changes in MRS neuronal markers and T cell phenotypes observed during early HIV infection.
Neurology 2009;72(17):1465-72.
2009: Leslie M Shaw; hugo vanderstichele; Malgorzata Knapik-Czajka; Christopher M Clark; Paul S Aisen; Ronald C. Petersen; Kaj Blennow; Holly Soares; Adam Simon; Piotr Lewczuk; Robert Dean; Eric Siemers; William Potter; Virginia M-Y Lee; John Q Trojanowski
Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects.
Annals of neurology 2009;65(4):403-13.
2009: Lionel M Igaz; Linda K Kwong; Alice Chen-Plotkin; Matthew J Winton; Travis L Unger; Yan Xu; Manuela Neumann; John Q Trojanowski; Virginia M-Y Lee
Expression of TDP-43 C-terminal Fragments in Vitro Recapitulates Pathological Features of TDP-43 Proteinopathies.
The Journal of biological chemistry 2009;284(13):8516-24.
2009: Robert M Koffie; Melanie Meyer-Luehmann; Tadafumi Hashimoto; Kenneth W Adams; Matthew L Mielke; Monica Garcia-Alloza; Kristina D Micheva; Stephen J Smith; M Leo Kim; Virginia M-Y Lee; Bradley T Hyman; Tara L Spires-Jones
Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(10):4012-7.
2009: ZAVEN KHACHATURIAN; Peter J Snyder; Rachelle S Doody; Paul S Aisen; Meryl Comer; John Dwyer; Richard A Frank; Andrew Holzapfel; Ara Khachaturian; Amos D Korczyn; Allen D Roses; James W Simpkins; Lon S Schneider; Marilyn S Albert; Robert Egge; Aaron Deves; Steven Ferris; Barry D Greenberg; Carl Johnson; Walter A Kukull; Judes Poirier; Dale Schenk; William Thies; S Gauthier; Sid Gilman; Charles Bernick; Jeffrey L Cummings; Howard Fillit; Michael Grundman; Jeffrey A Kaye; Lennart Mucke; Barry Reisberg; Mary Sano; Oxana Pickeral; Ronald C. Petersen; Richard C Mohs; Maria Carrillo; Jody Corey-Bloom; Norman L Foster; Steve Jacobsen; Virginia M-Y Lee; William Z Potter; Marwan Sabbagh; David P Salmon; John Q Trojanowski; Nancy Wexler; Lisa J Bain
A roadmap for the prevention of dementia II: Leon Thal Symposium 2008.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2009;5(2):85-92.
2009: Felix Geser; Maria Martinez-Lage; John Robinson; Kunihiro Uryu; Manuela Neumann; Nicholas J Brandmeir; Sharon X Xie; Linda K Kwong; Lauren B Elman; Leo McCluskey; Chris M Clark; Joe Malunda; Bruce L Miller; Earl A Zimmerman; Jiang Qian; Vivianna M Van Deerlin; Murray Grossman; Virginia M-Y Lee; John Q Trojanowski
Clinical and pathological continuum of multisystem TDP-43 proteinopathies.
Archives of neurology 2009;66(2):180-9.
2009: Manuela Neumann; Linda K Kwong; Edward B Lee; Elisabeth Kremmer; Andrew Flatley; Yan Xu; Mark S Forman; Dirk Troost; Hans A Kretzschmar; John Q Trojanowski; Virginia M-Y Lee
Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies.
Acta neuropathologica 2009;117(2):137-49.
2009: Erik Portelius; Bin Zhang; Mikael K Gustavsson; Gunnar Brinkmalm; Ann Westman-Brinkmalm; Henrik Zetterberg; Virginia M-Y Lee; John Q Trojanowski; Kaj Blennow
Effects of gamma-secretase inhibition on the amyloid beta isoform pattern in a mouse model of Alzheimer's disease.
Neuro-degenerative diseases 2009;6(5-6):258-62.
2008: Carlo Ballatore; Bin Zhang; John Q Trojanowski; Virginia M-Y Lee; Amos B Smith
In situ blood-brain barrier permeability of a C-10 paclitaxel carbamate.
Bioorganic & medicinal chemistry letters 2008;18(23):6119-21.
2008: Kelvin C Luk; Ian P Mills; John Q Trojanowski; Virginia M-Y Lee
Interactions between Hsp70 and the hydrophobic core of alpha-synuclein inhibit fibril assembly.
Biochemistry 2008;47(47):12614-25.
2008: Bin Ji; Jun Maeda; Makoto Sawada; Maiko Ono; Takashi Okauchi; Motoki Inaji; Ming-Rong Zhang; Kazutoshi Suzuki; Kiyoshi Ando; Matthias Staufenbiel; John Q Trojanowski; Virginia M-Y Lee; Makoto Higuchi; Tetsuya Suhara
Imaging of peripheral benzodiazepine receptor expression as biomarkers of detrimental versus beneficial glial responses in mouse models of Alzheimer's and other CNS pathologies.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(47):12255-67.
2008: Minkyu L Kim; Bin Zhang; Ian P Mills; Marcos E Milla; Kurt R Brunden; Virginia M-Y Lee
Effects of TNFalpha-converting enzyme inhibition on amyloid beta production and APP processing in vitro and in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(46):12052-61.
2008: Petra Steinacker; Corinna Hendrich; Anne-Dorte Sperfeld; Sarah Jesse; Christine A F Von Arnim; Stefan Lehnert; Alice Pabst; Ingo Uttner; Hayrettin Tumani; Virginia M-Y Lee; John Q Trojanowski; Hans A Kretzschmar; Albert C Ludolph; Manuela Neumann; Markus Otto
TDP-43 in cerebrospinal fluid of patients with frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
Archives of neurology 2008;65(11):1481-7.
2008: Simona Vuletic; Ge Li; Elaine Peskind; Hal Kennedy; Santica M Marcovina; James B Leverenz; Eric C Petrie; Virginia M-Y Lee; Douglas Galasko; Gerard D Schellenberg; John J Albers
Apolipoprotein E highly correlates with AbetaPP- and tau-related markers in human cerebrospinal fluid.
Journal of Alzheimer's disease : JAD 2008;15(3):409-17.
2008: Peter Kühnlein; Anne-Dorte Sperfeld; Ben Vanmassenhove; Vivianna Van Deerlin; Virginia M-Y Lee; John Q Trojanowski; Hans A Kretzschmar; Albert C Ludolph; Manuela Neumann
Two German kindreds with familial amyotrophic lateral sclerosis due to TARDBP mutations.
Archives of neurology 2008;65(9):1185-9.
2008: Kurt R Brunden; John Q Trojanowski; Virginia M-Y Lee
Evidence that non-fibrillar tau causes pathology linked to neurodegeneration and behavioral impairments.
Journal of Alzheimer's disease : JAD 2008;14(4):393-9.
2008: Hui-Ming Gao; Paul T Kotzbauer; Kunihiro Uryu; Susan Leight; John Q Trojanowski; Virginia M-Y Lee
Neuroinflammation and oxidation/nitration of alpha-synuclein linked to dopaminergic neurodegeneration.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(30):7687-98.
2008: Lionel M Igaz; Linda K Kwong; Yan Xu; Adam C Truax; Kunihiro Uryu; Manuela Neumann; Christopher M Clark; Lauren B Elman; Bruce L Miller; Murray Grossman; Leo McCluskey; John Q Trojanowski; Virginia M-Y Lee
Enrichment of C-terminal fragments in TAR DNA-binding protein-43 cytoplasmic inclusions in brain but not in spinal cord of frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
The American journal of pathology 2008;173(1):182-94.
2008: King-Ho Cheung; Diana Shineman; Marioly Müller; César Cárdenas; Lijuan Mei; Jun Yang; Taisuke Tomita; Takeshi Iwatsubo; Virginia M-Y Lee; J Kevin Foskett
Mechanism of Ca2+ disruption in Alzheimer's disease by presenilin regulation of InsP3 receptor channel gating.
Neuron 2008;58(6):871-83.
2008: Matthew J Winton; Vivianna M Van Deerlin; Linda K Kwong; Wuxing Yuan; Elisabeth McCarty Wood; Chang-En Yu; Gerard D Schellenberg; Rosa Rademakers; Richard Caselli; Anna Karydas; John Q Trojanowski; Bruce L Miller; Virginia M-Y Lee
A90V TDP-43 variant results in the aberrant localization of TDP-43 in vitro.
FEBS letters 2008;582(15):2252-6.
2008: Kunihiro Uryu; Hanae Nakashima-Yasuda; Mark S Forman; Linda K Kwong; Christopher M Clark; Murray Grossman; Bruce L Miller; Hans A Kretzschmar; Virginia M-Y Lee; John Q Trojanowski; Manuela Neumann
Concomitant TAR-DNA-binding protein 43 pathology is present in Alzheimer disease and corticobasal degeneration but not in other tauopathies.
Journal of neuropathology and experimental neurology 2008;67(6):555-64.
2008: Murray Grossman; Sharon X Xie; David J Libon; X Wang; Lauren Massimo; Peachie Moore; L Vesely; R Berkowitz; Anjan Chatterjee; H Branch Coslett; Howard I Hurtig; Mark S Forman; Virginia M-Y Lee; John Q Trojanowski
Longitudinal decline in autopsy-defined frontotemporal lobar degeneration.
Neurology 2008;70(22):2036-45.
2008: Alice S Chen-Plotkin; Felix Geser; Joshua B Plotkin; Christopher M Clark; Linda K Kwong; Wuxing Yuan; Murray Grossman; Vivianna M Van Deerlin; John Q Trojanowski; Virginia M-Y Lee
Variations in the progranulin gene affect global gene expression in frontotemporal lobar degeneration.
Human molecular genetics 2008;17(10):1349-62.
2008: Subhojit Roy; Matthew J Winton; Mark M Black; John Q Trojanowski; Virginia M-Y Lee
Cytoskeletal requirements in axonal transport of slow component-b.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(20):5248-56.
2008: Matthew J Winton; Lionel M Igaz; Margaret M Wong; Linda K Kwong; John Q Trojanowski; Virginia M-Y Lee
Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formation.
The Journal of biological chemistry 2008;283(19):13302-9.
2008: H Bian; J C Van Swieten; Susan Leight; Lauren Massimo; E Wood; M Forman; Peachie Moore; I de Koning; Christopher M Clark; S Rosso; John Q Trojanowski; Virginia M-Y Lee; Murray Grossman
CSF biomarkers in frontotemporal lobar degeneration with known pathology.
Neurology 2008;70(19 Pt 2):1827-35.
2008: Felix Geser; Nicholas J Brandmeir; Linda K Kwong; Maria Martinez-Lage; Lauren B Elman; Leo McCluskey; Sharon X Xie; Virginia M-Y Lee; John Q Trojanowski
Evidence of multisystem disorder in whole-brain map of pathological TDP-43 in amyotrophic lateral sclerosis.
Archives of neurology 2008;65(5):636-41.
2008: Jormay Lim; Martin Balastik; Tae Ho Lee; Kazuhiro Nakamura; Yih-Cherng Liou; Anyang Sun; Greg Finn; Lucia Pastorino; Virginia M-Y Lee; Kun Ping Lu
Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy.
The Journal of clinical investigation 2008;118(5):1877-89.
2008: Vivianna M Van Deerlin; James B Leverenz; Lynn M Bekris; Thomas D Bird; Wuxing Yuan; Lauren B Elman; Dana Clay; Elisabeth McCarty Wood; Alice S Chen-Plotkin; Maria Martinez-Lage; Ellen Steinbart; Leo McCluskey; Murray Grossman; Manuela Neumann; I-Lin Wu; Wei-Shiung Yang; Robert Kalb; Douglas Galasko; Thomas J Montine; John Q Trojanowski; Virginia M-Y Lee; Gerard D Schellenberg; Chang-En Yu
TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: a genetic and histopathological analysis.
Lancet neurology 2008;7(5):409-16.
2008: Diana W Shineman; Bin Zhang; Susan Leight; Domenico Pratico'; Virginia M-Y Lee
Thromboxane receptor activation mediates isoprostane-induced increases in amyloid pathology in Tg2576 mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(18):4785-94.
2008: James H Soper; Subhojit Roy; Anna Stieber; Eliza Lee; Robert B Wilson; John Q Trojanowski; Christopher G Burd; Virginia M-Y Lee
Alpha-synuclein-induced aggregation of cytoplasmic vesicles in Saccharomyces cerevisiae.
Molecular biology of the cell 2008;19(3):1093-103.
2008: Edward B Lee; Virginia M-Y Lee; John Q Trojanowski; Manuela Neumann
TDP-43 immunoreactivity in anoxic, ischemic and neoplastic lesions of the central nervous system.
Acta neuropathologica 2008;115(3):305-11.
2008: A S Chen-Plotkin; W Yuan; C Anderson; E McCarty Wood; Howard I Hurtig; Christopher M Clark; Bruce L Miller; Virginia M-Y Lee; John Q Trojanowski; Murray Grossman; Vivianna M Van Deerlin
Corticobasal syndrome and primary progressive aphasia as manifestations of LRRK2 gene mutations.
Neurology 2008;70(7):521-7.
2008: Vanessa A Morais; Susan Leight; Donald Pijak; Virginia M-Y Lee; Júlia Costa
Cellular localization of Nicastrin affects amyloid beta species production.
FEBS letters 2008;582(3):427-33.
2008: Sharon X Xie; Mark S Forman; Jennifer Farmer; Peachie Moore; Y Wang; X Wang; Christopher M Clark; H Branch Coslett; Anjan Chatterjee; Steven E Arnold; H Rosen; Jason H T Karlawish; Vivianna M Van Deerlin; Virginia M-Y Lee; John Q Trojanowski; Murray Grossman
Factors associated with survival probability in autopsy-proven frontotemporal lobar degeneration.
Journal of neurology, neurosurgery, and psychiatry 2008;79(2):126-9.
2008: John Q Trojanowski; Joan C Hendricks; Kathryn Jedrziewski; F Brad Johnson; Kathryn E Michel; Rebecka S Hess; Michael P Cancro; Meg M Sleeper; Robert Pignolo; Karen L Teff; Gustavo D Aguirre; Virginia M-Y Lee; Dennis F Lawler; Allan I Pack; Peter F Davies
Exploring human/animal intersections: converging lines of evidence in comparative models of aging.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2008;4(1):1-5.
2008: Linda K Kwong; Kunihiro Uryu; John Q Trojanowski; Virginia M-Y Lee
TDP-43 proteinopathies: neurodegenerative protein misfolding diseases without amyloidosis.
Neuro-Signals 2008;16(1):41-51.
2008: Christopher M Clark; Christos Davatzikos; A Borthakur; A Newberg; Susan Leight; Virginia M-Y Lee; John Q Trojanowski
Biomarkers for early detection of Alzheimer pathology.
Neuro-Signals 2008;16(1):11-8.
2008: Nicholas J Brandmeir; Felix Geser; Linda K Kwong; Earl Zimmerman; Jiang Qian; Virginia M-Y Lee; John Q Trojanowski
Severe subcortical TDP-43 pathology in sporadic frontotemporal lobar degeneration with motor neuron disease.
Acta neuropathologica 2008;115(1):123-31.
2008: Felix Geser; Matthew J Winton; Linda K Kwong; Yan Xu; Sharon X Xie; Lionel M Igaz; Ralph M Garruto; Daniel P Perl; Douglas Galasko; Virginia M-Y Lee; John Q Trojanowski
Pathological TDP-43 in parkinsonism-dementia complex and amyotrophic lateral sclerosis of Guam.
Acta neuropathologica 2008;115(1):133-45.
2007: Kunihiro Uryu; Xiao-Han Chen; Dan Martinez; Kevin D Browne; Victoria E Johnson; David I Graham; Virginia M-Y Lee; John Q Trojanowski; Douglas H Smith
Multiple proteins implicated in neurodegenerative diseases accumulate in axons after brain trauma in humans.
Experimental neurology 2007;208(2):185-92.
2007: Kelvin Luk; Edward G Hyde; John Q Trojanowski; Virginia M-Y Lee
Sensitive fluorescence polarization technique for rapid screening of alpha-synuclein oligomerization/fibrillization inhibitors.
Biochemistry 2007;46(44):12522-9.
2007: Murray Grossman; David J Libon; Mark S Forman; Lauren Massimo; Elisabeth Wood; Peachie Moore; Chivon Anderson; Jennifer Farmer; Anjan Chatterjee; Christopher M Clark; H Branch Coslett; Howard I Hurtig; Virginia M-Y Lee; John Q Trojanowski
Distinct antemortem profiles in patients with pathologically defined frontotemporal dementia.
Archives of neurology 2007;64(11):1601-9.
2007: Mark S Forman; John Q Trojanowski; Virginia M-Y Lee
TDP-43: a novel neurodegenerative proteinopathy.
Current opinion in neurobiology 2007;17(5):548-55.
2007: Murray Grossman; Elisabeth M Wood; Peachie Moore; Manuela Neumann; Linda K Kwong; Mark S Forman; Christopher M Clark; Leo McCluskey; Bruce L Miller; Virginia M-Y Lee; John Q Trojanowski
TDP-43 pathologic lesions and clinical phenotype in frontotemporal lobar degeneration with ubiquitin-positive inclusions.
Archives of neurology 2007;64(10):1449-54.
2007: Manuela Neumann; Linda K Kwong; Deepak M Sampathu; John Q Trojanowski; Virginia M-Y Lee
TDP-43 proteinopathy in frontotemporal lobar degeneration and amyotrophic lateral sclerosis: protein misfolding diseases without amyloidosis.
Archives of neurology 2007;64(10):1388-94.
2007: Carlo Ballatore; Virginia M-Y Lee; John Q Trojanowski
Tau-mediated neurodegeneration in Alzheimer's disease and related disorders.
Nature reviews. Neuroscience 2007;8(9):663-72.
2007: Hanae Nakashima-Yasuda; Kunihiro Uryu; John Robinson; Sharon X Xie; Howard I Hurtig; John E Duda; Steven E Arnold; Andrew Siderowf; Murray Grossman; James B Leverenz; Randall L Woltjer; Oscar L Lopez; Ronald Hamilton; Debby W Tsuang; Douglas Galasko; Eliezer Masliah; Jeffrey A Kaye; Christopher M Clark; Thomas J Montine; Virginia M-Y Lee; John Q Trojanowski
Co-morbidity of TDP-43 proteinopathy in Lewy body related diseases.
Acta neuropathologica 2007;114(3):221-9.
2007: Vivianna M Van Deerlin; Elisabeth McCarty Wood; Peachie Moore; Wuxing Yuan; Mark S Forman; Christopher M Clark; Manuela Neumann; Linda K Kwong; John Q Trojanowski; Virginia M-Y Lee; Murray Grossman
Clinical, genetic, and pathologic characteristics of patients with frontotemporal dementia and progranulin mutations.
Archives of neurology 2007;64(8):1148-53.
2007: Nigel J Cairns; Manuela Neumann; Eileen H Bigio; Ida E Holm; Dirk Troost; Kimmo J Hatanpaa; Chan Foong; Charles L White; Julie A Schneider; Hans A Kretzschmar; Deborah Carter; Lisa Taylor-Reinwald; Katherine Paulsmeyer; Jeffrey Strider; Michael Gitcho; Alison Goate; John C Morris; Manjari Mishra; Linda K Kwong; Anna Stieber; Yan Xu; Mark S Forman; John Q Trojanowski; Virginia M-Y Lee; Ian R A Mackenzie
TDP-43 in familial and sporadic frontotemporal lobar degeneration with ubiquitin inclusions.
The American journal of pathology 2007;171(1):227-40.
2007: Nigel J Cairns; Eileen H Bigio; Ian R A Mackenzie; Manuela Neumann; Virginia M-Y Lee; Kimmo J Hatanpaa; Charles L White; Julie A Schneider; Lea Tenenholz Grinberg; Glenda Halliday; Charles Duyckaerts; James S Lowe; Ida E Holm; Markus Tolnay; Koichi Okamoto; Hideaki Yokoo; Shigeo Murayama; John Woulfe; David G Munoz; dennis dickson; Paul Geoffrey Ince; John Q Trojanowski; D M A Mann
Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration.
Acta neuropathologica 2007;114(1):5-22.
2007: Doo Yeon Kim; Bryce W Carey; Haibin Wang; Laura A Mackenzie Ingano; Alexander M Binshtok; Mary H Wertz; Warren H Pettingell; Ping He; Virginia M-Y Lee; Clifford J Woolf; Dora M. Kovacs
BACE1 regulates voltage-gated sodium channels and neuronal activity.
Nature cell biology 2007;9(7):755-64.
2007: Linda K Kwong; Manuela Neumann; Deepak M Sampathu; Virginia M-Y Lee; John Q Trojanowski
TDP-43 proteinopathy: the neuropathology underlying major forms of sporadic and familial frontotemporal lobar degeneration and motor neuron disease.
Acta neuropathologica 2007;114(1):63-70.
2007: Carlo Ballatore; Edward Hyde; Robert F Deiches; Virginia M-Y Lee; John Q Trojanowski; Donna Huryn; Amos B Smith
Paclitaxel C-10 carbamates: potential candidates for the treatment of neurodegenerative tauopathies.
Bioorganic & medicinal chemistry letters 2007;17(13):3642-6.
2007: Se Hoon Choi; Susan N Leight; Virginia M-Y Lee; Tong Li; Philip C Wong; Jeffrey A Johnson; Maria J Saraiva; Sangram S Sisodia
Accelerated Abeta deposition in APPswe/PS1deltaE9 mice with hemizygous deletions of TTR (transthyretin).
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(26):7006-10.
2007: Alex Crowe; Carlo Ballatore; Edward Hyde; John Q Trojanowski; Virginia M-Y Lee
High throughput screening for small molecule inhibitors of heparin-induced tau fibril formation.
Biochemical and biophysical research communications 2007;358(1):1-6.
2007: Ian R A Mackenzie; Eileen H Bigio; Paul Geoffrey Ince; Felix Geser; Manuela Neumann; Nigel J Cairns; Linda K Kwong; Mark S Forman; John Ravits; Heather Stewart; Andrew Eisen; Leo McClusky; Hans A Kretzschmar; Camelia M Monoranu; J Robin Highley; Janine Kirby; Teepu Siddique; Pamela J Shaw; Virginia M-Y Lee; John Q Trojanowski
Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations.
Annals of neurology 2007;61(5):427-34.
2007: James B Leverenz; Chang-En Yu; Thomas J Montine; Ellen J Steinbart; L M Bekris; Cyrus Zabetian; L K Kwong; Virginia M-Y Lee; Gerard D Schellenberg; Thomas D Bird
A novel progranulin mutation associated with variable clinical presentation and tau, TDP43 and alpha-synuclein pathology.
Brain : a journal of neurology 2007;130(Pt 5):1360-74.
2007: Manuela Neumann; Lionel Igaz; Linda K Kwong; Hanae Nakashima-Yasuda; Stephen J Kolb; Gideon Dreyfuss; Hans A Kretzschmar; John Q Trojanowski; Virginia M-Y Lee
Absence of heterogeneous nuclear ribonucleoproteins and survival motor neuron protein in TDP-43 positive inclusions in frontotemporal lobar degeneration.
Acta neuropathologica 2007;113(5):543-8.
2007: Catarina Brito; Cristina Escrevente; Celso A Reis; Virginia M-Y Lee; John Q Trojanowski; Júlia Costa
Increased levels of fucosyltransferase IX and carbohydrate Lewis(x) adhesion determinant in human NT2N neurons.
Journal of neuroscience research 2007;85(6):1260-70.
2007: R Murray; Manuela Neumann; Mark S Forman; Jennifer Farmer; Lauren Massimo; A Rice; Bruce L Miller; Julene K Johnson; Christopher M Clark; Howard I Hurtig; Maria Luisa Gorno-Tempini; Virginia M-Y Lee; John Q Trojanowski; Murray Grossman
Cognitive and motor assessment in autopsy-proven corticobasal degeneration.
Neurology 2007;68(16):1274-83.
2007: M Kathryn Jedrziewski; Virginia M-Y Lee; John Q Trojanowski
Physical activity and cognitive health.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2007;3(2):98-108.
2007: Leslie M Shaw; Magdalena Korecka; Christopher M Clark; Virginia M-Y Lee; John Q Trojanowski
Biomarkers of neurodegeneration for diagnosis and monitoring therapeutics.
Nature reviews. Drug discovery 2007;6(4):295-303.
2007: Vivianna M Van Deerlin; Mark S Forman; Jennifer M Farmer; Murray Grossman; Sonali Joyce; Alex Crowe; John Q Trojanowski; Virginia M-Y Lee; Anjan Chatterjee
Biochemical and pathological characterization of frontotemporal dementia due to a Leu266Val mutation in microtubule-associated protein tau in an African American individual.
Acta neuropathologica 2007;113(4):471-9.
2007: Subhojit Roy; Matthew J Winton; Mark M Black; John Q Trojanowski; Virginia M-Y Lee
Rapid and intermittent cotransport of slow component-b proteins.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(12):3131-8.
2007: Carol F Lippa; J E Duda; Murray Grossman; Howard I Hurtig; Dag Aarsland; Bradley Boeve; David J Brooks; dennis dickson; Bruno Dubois; M Emre; Stanley Fahn; J M Farmer; Douglas Galasko; James E Galvin; Christopher G Goetz; John H Growdon; Katrina Gwinn-Hardy; John Hardy; Peter Heutink; Takeshi Iwatsubo; K Kosaka; Virginia M-Y Lee; James B Leverenz; Eliezer Masliah; Ian G McKeith; Robert L Nussbaum; C Warren Olanow; B M Ravina; Andrew Singleton; Caroline M Tanner; John Q Trojanowski; Zbigniew K Wszolek
DLB and PDD boundary issues: diagnosis, treatment, molecular pathology, and biomarkers.
Neurology 2007;68(11):812-9.
2007: Mark S Forman; Elliott J Mufson; S Leurgans; Domenico Pratico'; S Joyce; Susan Leight; Virginia M-Y Lee; John Q Trojanowski
Cortical biochemistry in MCI and Alzheimer disease: lack of correlation with clinical diagnosis.
Neurology 2007;68(10):757-63.
2007: Manuela Neumann; Linda K Kwong; Adam C Truax; Ben Vanmassenhove; Hans A Kretzschmar; Vivianna M Van Deerlin; Christopher M Clark; Murray Grossman; Bruce L Miller; John Q Trojanowski; Virginia M-Y Lee
TDP-43-positive white matter pathology in frontotemporal lobar degeneration with ubiquitin-positive inclusions.
Journal of neuropathology and experimental neurology 2007;66(3):177-83.
2007: Yasumasa Yoshiyama; Makoto Higuchi; Bin Zhang; Shu-Ming Huang; Nobuhisa Iwata; Takaomi C Saido; Jun Maeda; Tetsuya Suhara; John Q Trojanowski; Virginia M-Y Lee
Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model.
Neuron 2007;53(3):337-51.
2007: Erin H Norris; Kunihiro Uryu; Susan Leight; Benoit I Giasson; John Q Trojanowski; Virginia M-Y Lee
Pesticide exposure exacerbates alpha-synucleinopathy in an A53T transgenic mouse model.
The American journal of pathology 2007;170(2):658-66.
2006: Wenkai Li; Virginia M-Y Lee
Characterization of two VQIXXK motifs for tau fibrillization in vitro.
Biochemistry 2006;45(51):15692-701.
2006: Robert G Riekse; Ge Li; Eric C Petrie; James B Leverenz; Darcy Vavrek; Simona Vuletic; John J Albers; Thomas J Montine; Virginia M-Y Lee; Michael K Lee; Peter Seubert; Douglas Galasko; Gerard D Schellenberg; William R Hazzard; Elaine Peskind
Effect of statins on Alzheimer's disease biomarkers in cerebrospinal fluid.
Journal of Alzheimer's disease : JAD 2006;10(4):399-406.
2006: Arijitt Borthakur; Tamar L Gur; Andrew J Wheaton; Matthew Corbo; John Q Trojanowski; Virginia M-Y Lee; Ravinder Reddy
In vivo measurement of plaque burden in a mouse model of Alzheimer's disease.
Journal of magnetic resonance imaging : JMRI 2006;24(5):1011-7.
2006: Yuxin Fan; Pornprot Limprasert; Ian V J Murray; Annette C Smith; Virginia M-Y Lee; John Q Trojanowski; Bryce L Sopher; Albert R La Spada
Beta-synuclein modulates alpha-synuclein neurotoxicity by reducing alpha-synuclein protein expression.
Human molecular genetics 2006;15(20):3002-11.
2006: Manuela Neumann; Deepak M Sampathu; Linda K Kwong; Adam C Truax; Matthew Micsenyi; Thomas T Chou; Jennifer Bruce; Theresa Schuck; Murray Grossman; Christopher M Clark; Leo McCluskey; Bruce L Miller; Eliezer Masliah; Ian R A Mackenzie; Howard Feldman; Wolfgang Feiden; Hans A Kretzschmar; John Q Trojanowski; Virginia M-Y Lee
Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
Science (New York, N.Y.) 2006;314(5796):130-3.
2006: Virginia M-Y Lee; John Q Trojanowski
Mechanisms of Parkinson's disease linked to pathological alpha-synuclein: new targets for drug discovery.
Neuron 2006;52(1):33-8.
2006: M Flint Beal; Ella Bossy-Wetzel; Steven Finkbeiner; Gary Fiskum; Benoit Giasson; Carl Johnson; ZAVEN KHACHATURIAN; Virginia M-Y Lee; David Nicholls; P Hemachandra Reddy; Ian Reynolds; David B Teplow; Leon J Thal; John Q Trojanowski; Dominic M Walsh; Ronald B. Wetzel; Nancy S Wexler; Anne B Young; Lisa Bain
Common threads in neurodegenerative disorders of aging.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2006;2(4):322-6.
2006: Christopher M Clark; Domenico Pratico'; Lesley M Shaw; Susan Leight; Sharon X Xie; Amy Gu; Virginia M-Y Lee; John Q Trojanowski
Commentary on "Optimal design of clinical trials for drugs designed to slow the course of Alzheimer's disease." Biochemical biomarkers of late-life dementia.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2006;2(4):287-93.
2006: Deepak M Sampathu; Manuela Neumann; Linda K Kwong; Thomas T Chou; Matthew Micsenyi; Adam C Truax; Jennifer Bruce; Murray Grossman; John Q Trojanowski; Virginia M-Y Lee
Pathological heterogeneity of frontotemporal lobar degeneration with ubiquitin-positive inclusions delineated by ubiquitin immunohistochemistry and novel monoclonal antibodies.
The American journal of pathology 2006;169(4):1343-52.
2006: Ozlem Goker-Alpan; Benoit I Giasson; Michael J Eblan; J Nguyen; Howard I Hurtig; Virginia M-Y Lee; John Q Trojanowski; Ellen Sidransky
Glucocerebrosidase mutations are an important risk factor for Lewy body disorders.
Neurology 2006;67(5):908-10.
2006: Victoria Zhukareva; Sonali Joyce; Teresa Schuck; Vivianna M Van Deerlin; Howard I Hurtig; Roger L Albin; Sid Gilman; Steven Chin; Bruce L Miller; John Q Trojanowski; Virginia M-Y Lee
Unexpected abundance of pathological tau in progressive supranuclear palsy white matter.
Annals of neurology 2006;60(3):335-45.
2006: Kangning Liu; Ingrid Solano; D M A Mann; Cynthia A Lemere; Marc Mercken; John Q Trojanowski; Virginia M-Y Lee
Characterization of Abeta11-40/42 peptide deposition in Alzheimer's disease and young Down's syndrome brains: implication of N-terminally truncated Abeta species in the pathogenesis of Alzheimer's disease.
Acta neuropathologica 2006;112(2):163-74.
2006: Elaine Peskind; Ge Li; Jane B Shofer; Joseph F Quinn; Jeffrey A Kaye; Christopher M Clark; Martin R Farlow; Charles DeCarli; Murray A Raskind; Gerard D Schellenberg; Virginia M-Y Lee; Douglas Galasko
Age and apolipoprotein E*4 allele effects on cerebrospinal fluid beta-amyloid 42 in adults with normal cognition.
Archives of neurology 2006;63(7):936-9.
2006: Mark S Forman; Jennifer Farmer; Julene K Johnson; Christopher M Clark; Steven E Arnold; H Branch Coslett; Anjan Chatterjee; Howard I Hurtig; Jason H T Karlawish; Howard J Rosen; Vivianna M Van Deerlin; Virginia M-Y Lee; Bruce L Miller; John Q Trojanowski; Murray Grossman
Frontotemporal dementia: clinicopathological correlations.
Annals of neurology 2006;59(6):952-62.
2006: Matthew J Winton; Sonali Joyce; Victoria Zhukareva; Domenico Practico; Daniel P Perl; Douglas Galasko; Ulla-Katrina Craig; John Q Trojanowski; Virginia M-Y Lee
Characterization of tau pathologies in gray and white matter of Guam parkinsonism-dementia complex.
Acta neuropathologica 2006;111(5):401-12.
2006: Tsao-Wei Liang; Adam C Truax; John Q Trojanowski; Virginia M-Y Lee; Matthew B Stern; Paul T Kotzbauer
Partial deficit of pantothenate kinase 2 catalytic activity in a case of tremor-predominant neurodegeneration with brain iron accumulation.
Movement disorders : official journal of the Movement Disorder Society 2006;21(5):718-22.
2006: Kunihiro Uryu; Christiane Richter-Landsberg; William Welch; Eveline Sun; Olaf Goldbaum; Erin H Norris; Chi-Tuan Pham; Ikuru Yazawa; Kristen Hilburger; Matthew Micsenyi; Benoit I Giasson; Nancy M Bonini; Virginia M-Y Lee; John Q Trojanowski
Convergence of heat shock protein 90 with ubiquitin in filamentous alpha-synuclein inclusions of alpha-synucleinopathies.
The American journal of pathology 2006;168(3):947-61.
2006: Edward B Lee; Lewis Z Leng; Bin Zhang; Linda K Kwong; John Q Trojanowski; Ted Abel; Virginia M-Y Lee
Targeting amyloid-beta peptide (Abeta) oligomers by passive immunization with a conformation-selective monoclonal antibody improves learning and memory in Abeta precursor protein (APP) transgenic mice.
The Journal of biological chemistry 2006;281(7):4292-9.
2006: Deepa V Dabir; Michael B Robinson; Eric Swanson; Bin Zhang; John Q Trojanowski; Virginia M-Y Lee; Mark S Forman
Impaired glutamate transport in a mouse model of tau pathology in astrocytes.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(2):644-54.
2006: Daniel M Skovronsky; Virginia M-Y Lee; John Q Trojanowski
Neurodegenerative diseases: new concepts of pathogenesis and their therapeutic implications.
Annual review of pathology 2006;1():151-70.
2006: Virginia M-Y Lee; John Q Trojanowski
Progress from Alzheimer's tangles to pathological tau points towards more effective therapies now.
Journal of Alzheimer's disease : JAD 2006;9(3 Suppl):257-62.
2005: Ian G McKeith; dennis dickson; J Lowe; M Emre; John T O'Brien; H Feldman; Jeffrey L Cummings; J E Duda; Carol F Lippa; Elaine K Perry; Dag Aarsland; Heii Arai; Clive G Ballard; Bradley Boeve; David J Burn; D Costa; T Del Ser; Bruno Dubois; Douglas Galasko; S Gauthier; Christopher G Goetz; E Gomez-Tortosa; G Halliday; Lawrence A Hansen; John Hardy; Takeshi Iwatsubo; Rajesh N. Kalaria; Daniel Kaufer; R A Kenny; Amos D Korczyn; Kenji Kosaka; Virginia M-Y Lee; Andrew J Lees; I Litvan; E Londos; Oscar L Lopez; Satoshi Minoshima; Yoshikuni Mizuno; J A Molina; E B Mukaetova-Ladinska; Florence Pasquier; Robert H Perry; J B Schulz; John Q Trojanowski; Masahito Yamada
Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium.
Neurology 2005;65(12):1863-72.
2005: Jill S Goldman; Jennifer M Farmer; E M Wood; Julene K Johnson; Adam L Boxer; John Neuhaus; Catherine Lomen-Hoerth; Kirk Wilhelmsen; Virginia M-Y Lee; Murray Grossman; Bruce L Miller
Comparison of family histories in FTLD subtypes and related tauopathies.
Neurology 2005;65(11):1817-9.
2005: Chen Zhang; Kathryn E Saatman; Nicolas C Royo; Kristie M Soltesz; Marie Millard; Joost W Schouten; Melissa Motta; Rachel Hoover; Asenia McMillan; Deborah J Watson; Virginia M-Y Lee; John Q Trojanowski; Tracy K McIntosh
Delayed transplantation of human neurons following brain injury in rats: a long-term graft survival and behavior study.
Journal of neurotrauma 2005;22(12):1456-74.
2005: Sid Gilman; S J May; Clifford W Shults; Caroline M Tanner; Walter A Kukull; Virginia M-Y Lee; Eliezer Masliah; Phillip Low; Paola Sandroni; John Q Trojanowski; Laurie J Ozelius; Tatiana Foroud
The North American Multiple System Atrophy Study Group.
Journal of neural transmission (Vienna, Austria : 1996) 2005;112(12):1687-94.
2005: Hanae Nakashima; Takeshi Ishihara; Pilar Suguimoto; Osamu Yokota; Etsuko Oshima; Aki Kugo; Seishi Terada; Takashi Hamamura; John Q Trojanowski; Virginia M-Y Lee; Shigetoshi Kuroda
Chronic lithium treatment decreases tau lesions by promoting ubiquitination in a mouse model of tauopathies.
Acta neuropathologica 2005;110(6):547-56.
2005: Bin Zhang; Sigrid C Veasey; Marcelo A Wood; Lewis Z Leng; Christine Kaminski; Susan Leight; Ted Abel; Virginia M-Y Lee; John Q Trojanowski
Impaired rapid eye movement sleep in the Tg2576 APP murine model of Alzheimer's disease with injury to pedunculopontine cholinergic neurons.
The American journal of pathology 2005;167(5):1361-9.
2005: John Q Trojanowski; Virginia M-Y Lee
Rous-Whipple Award Lecture. The Alzheimer's brain: finding out what's broken tells us how to fix it.
The American journal of pathology 2005;167(5):1183-8.
2005: Makoto Higuchi; Bin Zhang; Mark S Forman; Yasumasa Yoshiyama; John Q Trojanowski; Virginia M-Y Lee
Axonal degeneration induced by targeted expression of mutant human tau in oligodendrocytes of transgenic mice that model glial tauopathies.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(41):9434-43.
2005: M Kathryn Jedrziewski; Virginia M-Y Lee; John Q Trojanowski
Lowering the risk of Alzheimer's disease: evidence-based practices emerge from new research.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2005;1(2):152-60.
2005: John Q Trojanowski; Virginia M-Y Lee
Commentary on "Diagnosis of Alzheimer's disease: two decades of progress". Alzheimer's disease research: new opportunities for early diagnosis and drug discovery.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2005;1(2):119-20.
2005: Yasumasa Yoshiyama; Kunihiro Uryu; Makoto Higuchi; Luca Longhi; Rachel Hoover; Scott Fujimoto; Tracy McIntosh; Virginia M-Y Lee; John Q Trojanowski
Enhanced neurofibrillary tangle formation, cerebral atrophy, and cognitive deficits induced by repetitive mild brain injury in a transgenic tauopathy mouse model.
Journal of neurotrauma 2005;22(10):1134-41.
2005: Yuemang Yao; Christopher M Clark; John Q Trojanowski; Virginia M-Y Lee; Domenico Pratico'
Elevation of 12/15 lipoxygenase products in AD and mild cognitive impairment.
Annals of neurology 2005;58(4):623-6.
2005: John Q Trojanowski; Virginia M-Y Lee
Pathological tau: a loss of normal function or a gain in toxicity?
Nature neuroscience 2005;8(9):1136-7.
2005: Mark S Forman; Virginia M-Y Lee; John Q Trojanowski
Nosology of Parkinson's disease: looking for the way out of a quagmire.
Neuron 2005;47(4):479-82.
2005: Changwei Liu; Benoit I Giasson; Karen A Lewis; Virginia M-Y Lee; George N DeMartino; Philip J Thomas
A precipitating role for truncated alpha-synuclein and the proteasome in alpha-synuclein aggregation: implications for pathogenesis of Parkinson disease.
The Journal of biological chemistry 2005;280(24):22670-8.
2005: Erin H Norris; Benoit I Giasson; Roberto Hodara; Shaohua Xu; John Q Trojanowski; Harry Ischiropoulos; Virginia M-Y Lee
Reversible inhibition of alpha-synuclein fibrillization by dopaminochrome-mediated conformational alterations.
The Journal of biological chemistry 2005;280(22):21212-9.
2005: Sarah Grimwood; J Hogg; Mark T Jay; A M Lad; Virginia M-Y Lee; Fraser Murray; James E Peachey; T Townend; M Vithlani; Dirk Beher; Mark S Shearman; Peter H Hutson
Determination of guinea-pig cortical gamma-secretase activity ex vivo following the systemic administration of a gamma-secretase inhibitor.
Neuropharmacology 2005;48(7):1002-11.
2005: Amanda J Mishizen-Eberz; Erin H Norris; Benoit I Giasson; Roberto Hodara; Harry Ischiropoulos; Virginia M-Y Lee; John Q Trojanowski; David R Lynch
Cleavage of alpha-synuclein by calpain: potential role in degradation of fibrillized and nitrated species of alpha-synuclein.
Biochemistry 2005;44(21):7818-29.
2005: Edward B Lee; Lewis Z Leng; Virginia M-Y Lee; John Q Trojanowski
Meningoencephalitis associated with passive immunization of a transgenic murine model of Alzheimer's amyloidosis.
FEBS letters 2005;579(12):2564-8.
2005: John Q Trojanowski; Amos B Smith; Donna Huryn; Virginia M-Y Lee
Microtubule-stabilising drugs for therapy of Alzheimer's disease and other neurodegenerative disorders with axonal transport impairments.
Expert opinion on pharmacotherapy 2005;6(5):683-6.
2005: Ryan T Mott; dennis dickson; John Q Trojanowski; Victoria Zhukareva; Virginia M-Y Lee; Mark Forman; Vivianna M Van Deerlin; John F Ervin; Dengshun Wang; Donald E Schmechel; Christine M Hulette
Neuropathologic, biochemical, and molecular characterization of the frontotemporal dementias.
Journal of neuropathology and experimental neurology 2005;64(5):420-8.
2005: Murray Grossman; Jennifer Farmer; Susan Leight; Melissa Work; Peachie Moore; Vivianna M Van Deerlin; Domenico Pratico'; Christopher M Clark; H Branch Coslett; Anjan Chatterjee; James Gee; John Q Trojanowski; Virginia M-Y Lee
Cerebrospinal fluid profile in frontotemporal dementia and Alzheimer's disease.
Annals of neurology 2005;57(5):721-9.
2005: Mark S Forman; Devika Lal; Bin Zhang; Deepa V Dabir; Eric Swanson; Virginia M-Y Lee; John Q Trojanowski
Transgenic mouse model of tau pathology in astrocytes leading to nervous system degeneration.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(14):3539-50.
2005: Ikuru Yazawa; Benoit I Giasson; Ryogen Sasaki; Bin Zhang; Sonali Joyce; Kunihiro Uryu; John Q Trojanowski; Virginia M-Y Lee
Mouse model of multiple system atrophy alpha-synuclein expression in oligodendrocytes causes glial and neuronal degeneration.
Neuron 2005;45(6):847-59.
2005: Orly Lazarov; John Robinson; Ya-Ping Tang; Ilana S Hairston; Zeljka Korade-Mirnics; Virginia M-Y Lee; Louis B Hersh; Robert M Sapolsky; Károly Mirnics; Sangram S Sisodia
Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice.
Cell 2005;120(5):701-13.
2005: Orly Lazarov; Gerardo Morfini; Edward B Lee; Mohamed H Farah; Anita Szodorai; Scott R DeBoer; Vassilis E Koliatsos; Stefan Kins; Virginia M-Y Lee; Philip C Wong; Donald L Price; Scott T Brady; Sangram S Sisodia
Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(9):2386-95.
2005: Rachael Easton; Han Cho; Kristin Roovers; Diana W Shineman; Moshe Mizrahi; Mark S Forman; Virginia M-Y Lee; Matthias Szabolcs; Ron de Jong; Tilman Oltersdorf; Thomas Ludwig; Argiris Efstratiadis; Morris J Birnbaum
Role for Akt3/protein kinase Bgamma in attainment of normal brain size.
Molecular and cellular biology 2005;25(5):1869-78.
2005: Hugo Geerts; John Q Trojanowski; Virginia M-Y Lee
Drug discovery in neurodegenerative diseases.
Science of aging knowledge environment : SAGE KE 2005;2005(6):pe4.
2005: Paul T Kotzbauer; Adam C Truax; John Q Trojanowski; Virginia M-Y Lee
Altered neuronal mitochondrial coenzyme A synthesis in neurodegeneration with brain iron accumulation caused by abnormal processing, stability, and catalytic activity of mutant pantothenate kinase 2.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(3):689-98.
2005: Edward B Lee; Bin Zhang; Kangning Liu; Eric A Greenbaum; Robert W Doms; John Q Trojanowski; Virginia M-Y Lee
BACE overexpression alters the subcellular processing of APP and inhibits Abeta deposition in vivo.
The Journal of cell biology 2005;168(2):291-302.
2005: Bin Zhang; Arpita Maiti; Sharon Shively; Fara Lakhani; Gaye McDonald-Jones; Jennifer Bruce; Edward B Lee; Sharon X Xie; Sonali Joyce; Chi Li; Philip M Toleikis; Virginia M-Y Lee; John Q Trojanowski
Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(1):227-31.
2005: Virginia M-Y Lee; Theresa K Kenyon; John Q Trojanowski
Transgenic animal models of tauopathies.
Biochimica et biophysica acta 2005;1739(2-3):251-9.
2005: Subhojit Roy; Bin Zhang; Virginia M-Y Lee; John Q Trojanowski
Axonal transport defects: a common theme in neurodegenerative diseases.
Acta neuropathologica 2005;109(1):5-13.
2004: Luca Longhi; Deborah J Watson; Kathryn E Saatman; Hilaire J Thompson; Chen Zhang; Scott Fujimoto; Nicolas C Royo; Deborah Castelbuono; Ramesh Raghupathi; John Q Trojanowski; Virginia M-Y Lee; John H Wolfe; Nino Stocchetti; Tracy K McIntosh
Ex vivo gene therapy using targeted engraftment of NGF-expressing human NT2N neurons attenuates cognitive deficits following traumatic brain injury in mice.
Journal of neurotrauma 2004;21(12):1723-36.
2004: Anca Popescu; Carol F Lippa; Virginia M-Y Lee; John Q Trojanowski
Lewy bodies in the amygdala: increase of alpha-synuclein aggregates in neurodegenerative diseases with tau-based inclusions.
Archives of neurology 2004;61(12):1915-9.
2004: Syuan Sung; Hengxuan Yang; Kunihiro Uryu; Edward B Lee; Lei Zhao; Diana Shineman; John Q Trojanowski; Virginia M-Y Lee; Domenico Pratico'
Modulation of nuclear factor-kappa B activity by indomethacin influences A beta levels but not A beta precursor protein metabolism in a model of Alzheimer's disease.
The American journal of pathology 2004;165(6):2197-206.
2004: Roberto Hodara; Erin H Norris; Benoit I Giasson; Amanda J Mishizen-Eberz; David R Lynch; Virginia M-Y Lee; Harry Ischiropoulos
Functional consequences of alpha-synuclein tyrosine nitration: diminished binding to lipid vesicles and increased fibril formation.
The Journal of biological chemistry 2004;279(46):47746-53.
2004: Nigel J Cairns; Virginia M-Y Lee; John Q Trojanowski
The cytoskeleton in neurodegenerative diseases.
The Journal of pathology 2004;204(4):438-49.
2004: Milos D Ikonomovic; Kunihiro Uryu; Eric Abrahamson; John R Ciallella; John Q Trojanowski; Virginia M-Y Lee; Robert S B Clark; Donald W Marion; Stephen R Wisniewski; Steven T DeKosky
Alzheimer's pathology in human temporal cortex surgically excised after severe brain injury.
Experimental neurology 2004;190(1):192-203.
2004: Nigel J Cairns; Murray Grossman; Steven E Arnold; David J Burn; Evelyn Jaros; Robert H Perry; Charles Duyckaerts; B Stankoff; B Pillon; Kari Skullerud; F F Cruz-Sanchez; Eileen H Bigio; Ian R A Mackenzie; Marla Gearing; Jorge L Juncos; Jonathan D Glass; Hideaki Yokoo; Yoichi Nakazato; Sabrina Mosaheb; Julian R Thorpe; Kunihiro Uryu; Virginia M-Y Lee; John Q Trojanowski
Clinical and neuropathologic variation in neuronal intermediate filament inclusion disease.
Neurology 2004;63(8):1376-84.
2004: Mark S Forman; John Q Trojanowski; Virginia M-Y Lee
Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs.
Nature medicine 2004;10(10):1055-63.
2004: H Ohtake; Pornprot Limprasert; Y Fan; Osamu Onodera; Akiyoshi Kakita; Hidenobu Takahashi; Lauren T Bonner; Debby W Tsuang; Ian V J Murray; Virginia M-Y Lee; John Q Trojanowski; A Ishikawa; J Idezuka; M Murata; T Toda; Thomas D Bird; James B Leverenz; Shoji Tsuji; Albert R La Spada
Beta-synuclein gene alterations in dementia with Lewy bodies.
Neurology 2004;63(5):805-11.
2004: Nigel J Cairns; Kunihiro Uryu; Eileen H Bigio; Ian R A Mackenzie; Marla Gearing; Charles Duyckaerts; Hideaki Yokoo; Yoichi Nakazato; Evelyn Jaros; Robert H Perry; Steven E Arnold; Virginia M-Y Lee; John Q Trojanowski
alpha-Internexin aggregates are abundant in neuronal intermediate filament inclusion disease (NIFID) but rare in other neurodegenerative diseases.
Acta neuropathologica 2004;108(3):213-23.
2004: Valeria Conte; Kunihiro Uryu; Scott Fujimoto; Yuemang Yao; Joshua Rokach; Luca Longhi; John Q Trojanowski; Virginia M-Y Lee; Tracy K McIntosh; Domenico Pratico'
Vitamin E reduces amyloidosis and improves cognitive function in Tg2576 mice following repetitive concussive brain injury.
Journal of neurochemistry 2004;90(3):758-64.
2004: Hanae Nakashima; Takeshi Ishihara; Osamu Yokota; Seishi Terada; John Q Trojanowski; Virginia M-Y Lee; Shigetoshi Kuroda
Effects of alpha-tocopherol on an animal model of tauopathies.
Free radical biology & medicine 2004;37(2):176-86.
2004: Nigel J Cairns; Victoria Zhukareva; Kunihiro Uryu; Bin Zhang; Eileen H Bigio; Ian R A Mackenzie; Marla Gearing; Charles Duyckaerts; Hideaki Yokoo; Yoichi Nakazato; Evelyn Jaros; Robert H Perry; Virginia M-Y Lee; John Q Trojanowski
alpha-internexin is present in the pathological inclusions of neuronal intermediate filament inclusion disease.
The American journal of pathology 2004;164(6):2153-61.
2004: Paul T Kotzbauer; Benoit I Giasson; Alexxai V Kravitz; Lawrence I Golbe; Margery H Mark; John Q Trojanowski; Virginia M-Y Lee
Fibrillization of alpha-synuclein and tau in familial Parkinson's disease caused by the A53T alpha-synuclein mutation.
Experimental neurology 2004;187(2):279-88.
2004: Bin Zhang; Makoto Higuchi; Yasumasa Yoshiyama; Takeshi Ishihara; Mark S Forman; Dan Martinez; Sonali Joyce; John Q Trojanowski; Virginia M-Y Lee
Retarded axonal transport of R406W mutant tau in transgenic mice with a neurodegenerative tauopathy.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(19):4657-67.
2004: Christina A Wilson; Diane D Murphy; Benoit I Giasson; Bin Zhang; John Q Trojanowski; Virginia M-Y Lee
Degradative organelles containing mislocalized alpha-and beta-synuclein proliferate in presenilin-1 null neurons.
The Journal of cell biology 2004;165(3):335-46.
2004: Domenico Pratico'; Victoria Zhukareva; Yuemang Yao; Kunihiro Uryu; Colin D Funk; John A Lawson; John Q Trojanowski; Virginia M-Y Lee
12/15-lipoxygenase is increased in Alzheimer's disease: possible involvement in brain oxidative stress.
The American journal of pathology 2004;164(5):1655-62.
2004: Adam S Crystal; Vanessa A Morais; Ryan R Fortna; Dan Carlin; Theodore C Pierson; Christina A Wilson; Virginia M-Y Lee; Robert W Doms
Presenilin modulates Pen-2 levels posttranslationally by protecting it from proteasomal degradation.
Biochemistry 2004;43(12):3555-63.
2004: Jonathan B Macknin; Makoto Higuchi; Virginia M-Y Lee; John Q Trojanowski; Richard Doty
Olfactory dysfunction occurs in transgenic mice overexpressing human tau protein.
Brain research 2004;1000(1-2):174-8.
2004: Virginia M-Y Lee; Benoit I Giasson; John Q Trojanowski
More than just two peas in a pod: common amyloidogenic properties of tau and alpha-synuclein in neurodegenerative diseases.
Trends in neurosciences 2004;27(3):129-34.
2004: Kirk Wilhelmsen; Mark S Forman; Howard J Rosen; Loren I Alving; Jill Goldman; Jennie Feiger; James V Lee; Samantha K Segall; Joel H Kramer; Catherine Lomen-Hoerth; Katherine P Rankin; Julene Johnson; Heidi S Feiler; Michael Weiner; Virginia M-Y Lee; John Q Trojanowski; Bruce L Miller
17q-linked frontotemporal dementia-amyotrophic lateral sclerosis without tau mutations with tau and alpha-synuclein inclusions.
Archives of neurology 2004;61(3):398-406.
2004: Victoria Zhukareva; John Q Trojanowski; Virginia M-Y Lee
Assessment of pathological tau proteins in frontotemporal dementias: qualitative and quantitative approaches.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2004;12(2):136-45.
2004: Stuart Pickering-Brown; Matt Baker; Thomas D Bird; John Q Trojanowski; Virginia M-Y Lee; Huw Morris; Martin N Rossor; John C Janssen; David Neary; David Craufurd; Anna Richardson; Julie Snowden; John Hardy; D M A Mann; Michael Hutton
Evidence of a founder effect in families with frontotemporal dementia that harbor the tau +16 splice mutation.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2004;125B(1):79-82.
2004: Syuan Sung; Yuemang Yao; Kunihiro Uryu; Hengxuan Yang; Virginia M-Y Lee; John Q Trojanowski; Domenico Pratico'
Early vitamin E supplementation in young but not aged mice reduces Abeta levels and amyloid deposition in a transgenic model of Alzheimer's disease.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(2):323-5.
2004: Ryan R Fortna; Adam S Crystal; Vanessa A Morais; Donald Pijak; Virginia M-Y Lee; Robert W Doms
Membrane topology and nicastrin-enhanced endoproteolysis of APH-1, a component of the gamma-secretase complex.
The Journal of biological chemistry 2004;279(5):3685-93.
2004: Erin H Norris; Benoit I Giasson; Virginia M-Y Lee
Alpha-synuclein: normal function and role in neurodegenerative diseases.
Current topics in developmental biology 2004;60():17-54.
2004: Patrizia Rizzu; David A Hinkle; Victoria Zhukareva; Vincenzo Bonifati; Lies-Anne Severijnen; Daniel Martinez; Rivka Ravid; Wouter Kamphorst; james eberwine; Virginia M-Y Lee; John Q Trojanowski; Peter Heutink
DJ-1 colocalizes with tau inclusions: a link between parkinsonism and dementia.
Annals of neurology 2004;55(1):113-8.
2004: Deepa V Dabir; John Q Trojanowski; Christiane Richter-Landsberg; Virginia M-Y Lee; Mark S Forman
Expression of the small heat-shock protein alphaB-crystallin in tauopathies with glial pathology.
The American journal of pathology 2004;164(1):155-66.
2003: Christopher M Clark; Sharon Xie; Jesse Chittams; Douglas C Ewbank; Elaine Peskind; Douglas Galasko; John C Morris; Daniel W McKeel; Martin R Farlow; Sharon L Weitlauf; Joseph F Quinn; Jeffrey A Kaye; David S. Knopman; Hiroyuki Arai; Rachelle S Doody; Charles DeCarli; Susan Leight; Virginia M-Y Lee; John Q Trojanowski
Cerebrospinal fluid tau and beta-amyloid: how well do these biomarkers reflect autopsy-confirmed dementia diagnoses?
Archives of neurology 2003;60(12):1696-702.
2003: Aaron C Pawlyk; Benoit I Giasson; Deepak M Sampathu; Francisco A Perez; Kah Leong Lim; Valina Dawson; Ted M Dawson; Richard D Palmiter; John Q Trojanowski; Virginia M-Y Lee
Novel monoclonal antibodies demonstrate biochemical variation of brain parkin with age.
The Journal of biological chemistry 2003;278(48):48120-8.
2003: Yasumasa Yoshiyama; Bin Zhang; Jennifer Bruce; John Q Trojanowski; Virginia M-Y Lee
Reduction of detyrosinated microtubules and Golgi fragmentation are linked to tau-induced degeneration in astrocytes.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(33):10662-71.
2003: Hang F Kung; Mei-Ping Kung; Zhi-Ping Zhuang; Catherine Hou; Chi-Wan Lee; Karl Plössl; Bing Zhuang; Daniel M Skovronsky; Virginia M-Y Lee; John Q Trojanowski
Iodinated tracers for imaging amyloid plaques in the brain.
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 2003;5(6):418-26.
2003: Linda Söderberg; Victoria Zhukareva; Nenad Bogdanovic; Tadafumi Hashimoto; Bengt Winblad; Takeshi Iwatsubo; Virginia M-Y Lee; John Q Trojanowski; Jan Näslund
Molecular identification of AMY, an Alzheimer disease amyloid-associated protein.
Journal of neuropathology and experimental neurology 2003;62(11):1108-17.
2003: Kunihiro Uryu; Benoit I Giasson; Luca Longhi; D Martinez; I Murray; Valeria Conte; M Nakamura; Kathryn E Saatman; Konrad Talbot; T Horiguchi; Tracy McIntosh; Virginia M-Y Lee; John Q Trojanowski
Age-dependent synuclein pathology following traumatic brain injury in mice.
Experimental neurology 2003;184(1):214-24.
2003: Christina A Wilson; Robert W Doms; Virginia M-Y Lee
Distinct presenilin-dependent and presenilin-independent gamma-secretases are responsible for total cellular Abeta production.
Journal of neuroscience research 2003;74(3):361-9.
2003: David Nicholl; Michael Greenstone; Carl Clarke; Patrizia Rizzu; Daniel Crooks; Alex Crowe; John Q Trojanowski; Virginia M-Y Lee; Peter Heutink
An English kindred with a novel recessive tauopathy and respiratory failure.
Annals of neurology 2003;54(5):682-6.
2003: Vanessa A Morais; Adam S Crystal; Donald Pijak; Dan Carlin; Júlia Costa; Virginia M-Y Lee; Robert W Doms
The transmembrane domain region of nicastrin mediates direct interactions with APH-1 and the gamma-secretase complex.
The Journal of biological chemistry 2003;278(44):43284-91.
2003: Virginia M-Y Lee; John Q Trojanowski
Research on the brain.
Science of aging knowledge environment : SAGE KE 2003;2003(42):pe29.
2003: Olaf Goldbaum; Malte Oppermann; Melanie Handschuh; Deepa V Dabir; Bin Zhang; Mark S Forman; John Q Trojanowski; Virginia M-Y Lee; Christiane Richter-Landsberg
Proteasome inhibition stabilizes tau inclusions in oligodendroglial cells that occur after treatment with okadaic acid.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(26):8872-80.
2003: Vivianna M Van Deerlin; Lisa H Gill; Jennifer M Farmer; John Q Trojanowski; Virginia M-Y Lee
Familial frontotemporal dementia: from gene discovery to clinical molecular diagnostics.
Clinical chemistry 2003;49(10):1717-25.
2003: Adam S Crystal; Benoit I Giasson; Alexander Crowe; Mei-Ping Kung; Zhi-Ping Zhuang; John Q Trojanowski; Virginia M-Y Lee
A comparison of amyloid fibrillogenesis using the novel fluorescent compound K114.
Journal of neurochemistry 2003;86(6):1359-68.
2003: Takashi Horiguchi; Kunihiro Uryu; Benoit I Giasson; Harry Ischiropoulos; Richard LightFoot; Christine Bellmann; Christiane Richter-Landsberg; Virginia M-Y Lee; John Q Trojanowski
Nitration of tau protein is linked to neurodegeneration in tauopathies.
The American journal of pathology 2003;163(3):1021-31.
2003: Benoit I Giasson; Meghann E Mabon; John E Duda; Thomas J Montine; David Robertson; Howard I Hurtig; Virginia M-Y Lee; John Q Trojanowski
Tau and 14-3-3 in glial cytoplasmic inclusions of multiple system atrophy.
Acta neuropathologica 2003;106(3):243-50.
2003: Yuemang Yao; Victoria Zhukareva; Syuan Sung; Christopher M Clark; Joshua Rokach; Virginia M-Y Lee; John Q Trojanowski; Domenico Pratico'
Enhanced brain levels of 8,12-iso-iPF2alpha-VI differentiate AD from frontotemporal dementia.
Neurology 2003;61(4):475-8.
2003: John Q Trojanowski; Virginia M-Y Lee
Meeting summary--cell biology of Parkinson's disease and related neurodegenerative disorders.
Science of aging knowledge environment : SAGE KE 2003;2003(32):PE23.
2003: Mark S Forman; Virginia M-Y Lee; John Q Trojanowski
'Unfolding' pathways in neurodegenerative disease.
Trends in neurosciences 2003;26(8):407-10.
2003: Amanda J Mishizen-Eberz; Rodney P Guttmann; Benoit I Giasson; George A Day; Roberto Hodara; Harry Ischiropoulos; Virginia M-Y Lee; John Q Trojanowski; David R Lynch
Distinct cleavage patterns of normal and pathologic forms of alpha-synuclein by calpain I in vitro.
Journal of neurochemistry 2003;86(4):836-47.
2003: Kar-Ming Fung; Lucy B Rorke; Benoit I Giasson; Virginia M-Y Lee; John Q Trojanowski
Expression of alpha-, beta-, and gamma-synuclein in glial tumors and medulloblastomas.
Acta neuropathologica 2003;106(2):167-75.
2003: Ian V J Murray; Benoit I Giasson; Shawn M Quinn; Vishwanath Koppaka; Paul H Axelsen; Harry Ischiropoulos; John Q Trojanowski; Virginia M-Y Lee
Role of alpha-synuclein carboxy-terminus on fibril formation in vitro.
Biochemistry 2003;42(28):8530-40.
2003: Erin H Norris; Benoit I Giasson; Harry Ischiropoulos; Virginia M-Y Lee
Effects of oxidative and nitrative challenges on alpha-synuclein fibrillogenesis involve distinct mechanisms of protein modifications.
The Journal of biological chemistry 2003;278(29):27230-40.
2003: Benoit I Giasson; Virginia M-Y Lee
Are ubiquitination pathways central to Parkinson's disease?
Cell 2003;114(1):1-8.
2003: Deepak M Sampathu; Benoit I Giasson; Aaron C Pawlyk; John Q Trojanowski; Virginia M-Y Lee
Ubiquitination of alpha-synuclein is not required for formation of pathological inclusions in alpha-synucleinopathies.
The American journal of pathology 2003;163(1):91-100.
2003: John Q Trojanowski; Virginia M-Y Lee
Parkinson's disease and related alpha-synucleinopathies are brain amyloidoses.
Annals of the New York Academy of Sciences 2003;991():107-10.
2003: Sreekanth H Chalasani; Frédéric Baribaud; Christine M Coughlan; Mary J Sunshine; Virginia M-Y Lee; Robert W Doms; Dan R Littman; Jonathan A Raper
The chemokine stromal cell-derived factor-1 promotes the survival of embryonic retinal ganglion cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(11):4601-12.
2003: Adam S Crystal; Vanessa A Morais; Theodore C Pierson; Donald Pijak; Dan Carlin; Virginia M-Y Lee; Robert W Doms
Membrane topology of gamma-secretase component PEN-2.
The Journal of biological chemistry 2003;278(22):20117-23.
2003: Christopher J Phiel; Christina A Wilson; Virginia M-Y Lee; Peter S Klein
GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides.
Nature 2003;423(6938):435-9.
2003: Tzvete Dentchev; Ann H Milam; Virginia M-Y Lee; John Q Trojanowski; Joshua L Dunaief
Amyloid-beta is found in drusen from some age-related macular degeneration retinas, but not in drusen from normal retinas.
Molecular vision 2003;9():184-90.
2003: Jason Huse; Damani Byant; Yaxiong Yang; Donald Pijak; Ian D'Souza; James J Lah; Virginia M-Y Lee; Robert W Doms; David G Cook
Endoproteolysis of beta-secretase (beta-site amyloid precursor protein-cleaving enzyme) within its catalytic domain. A potential mechanism for regulation.
The Journal of biological chemistry 2003;278(19):17141-9.
2003: Maria-Jesús Sobrido; Bruce L Miller; Necat Havlioglu; Victoria Zhukareva; Zhihong Jiang; Ziad S Nasreddine; Virginia M-Y Lee; Tiffany W Chow; Kirk Wilhelmsen; Jeffrey L Cummings; Jane Y Wu; Daniel Geschwind
Novel tau polymorphisms, tau haplotypes, and splicing in familial and sporadic frontotemporal dementia.
Archives of neurology 2003;60(5):698-702.
2003: Victoria Zhukareva; Sonali Sundarraj; D M A Mann; Magnus Sjogren; Kaj Blenow; Christopher M Clark; Daniel W McKeel; Alison Goate; Carol F Lippa; Jean-Paul Vonsattel; John H Growdon; John Q Trojanowski; Virginia M-Y Lee
Selective reduction of soluble tau proteins in sporadic and familial frontotemporal dementias: an international follow-up study.
Acta neuropathologica 2003;105(5):469-76.
2003: Benoit I Giasson; Mark S Forman; Makoto Higuchi; Lawrence I Golbe; Charles L Graves; Paul T Kotzbauer; John Q Trojanowski; Virginia M-Y Lee
Initiation and synergistic fibrillization of tau and alpha-synuclein.
Science (New York, N.Y.) 2003;300(5619):636-40.
2003: Deborah J Watson; Luca Longhi; Edward B Lee; Carl T Fulp; Scott Fujimoto; Nicolas C Royo; Marco A Passini; John Q Trojanowski; Virginia M-Y Lee; Tracy K McIntosh; John H Wolfe
Genetically modified NT2N human neuronal cells mediate long-term gene expression as CNS grafts in vivo and improve functional cognitive outcome following experimental traumatic brain injury.
Journal of neuropathology and experimental neurology 2003;62(4):368-80.
2003: Edward B Lee; Daniel M Skovronsky; Farhad Abtahian; Robert W Doms; Virginia M-Y Lee
Secretion and intracellular generation of truncated Abeta in beta-site amyloid-beta precursor protein-cleaving enzyme expressing human neurons.
The Journal of biological chemistry 2003;278(7):4458-66.
2003: Mei-Ping Kung; Daniel M Skovronsky; Catherine Hou; Zhi-Ping Zhuang; Tamar L Gur; Bin Zhang; John Q Trojanowski; Virginia M-Y Lee; Hank F Kung
Detection of amyloid plaques by radioligands for Abeta40 and Abeta42: potential imaging agents in Alzheimer's patients.
Journal of molecular neuroscience : MN 2003;20(1):15-24.
2003: Ian J Murray; Marlon A Medford; Hong-Ping Guan; Susan M Rueter; John Q Trojanowski; Virginia M-Y Lee
Synphilin in normal human brains and in synucleinopathies: studies with new antibodies.
Acta neuropathologica 2003;105(2):177-84.
2003: Benoit I Giasson; Virginia M-Y Lee; John Q Trojanowski
Interactions of amyloidogenic proteins.
Neuromolecular medicine 2003;4(1-2):49-58.
2003: Virginia M-Y Lee; Aidan Halligan; Leong L Ng
Neutrophil intracellular pH and Na+/H+ exchanger activity in pre-eclampsia.
Metabolism: clinical and experimental 2003;52(1):87-93.
2002: Benoit I Giasson; Deepak M Sampathu; Christina A Wilson; Vanessa Vogelsberg-Ragaglia; Walter E Mushynski; Virginia M-Y Lee
The environmental toxin arsenite induces tau hyperphosphorylation.
Biochemistry 2002;41(51):15376-87.
2002: Masato Hasegawa; Hideo Fujiwara; Takashi Nonaka; Koichi Wakabayashi; Hitoshi Takahashi; Virginia M-Y Lee; John Q Trojanowski; D M A Mann; Takeshi Iwatsubo
Phosphorylated alpha-synuclein is ubiquitinated in alpha-synucleinopathy lesions.
The Journal of biological chemistry 2002;277(50):49071-6.
2002: Gregory G Heuer; Marco A Passini; Kanli Jiang; Michael K Parente; Virginia M-Y Lee; John Q Trojanowski; John H Wolfe
Selective neurodegeneration in murine mucopolysaccharidosis VII is progressive and reversible.
Annals of neurology 2002;52(6):762-70.
2002: Mei-Ping Kung; Catherine Hou; Zhi-Ping Zhuang; Bin Zhang; Daniel M Skovronsky; John Q Trojanowski; Virginia M-Y Lee; Hank F Kung
IMPY: an improved thioflavin-T derivative for in vivo labeling of beta-amyloid plaques.
Brain research 2002;956(2):202-10.
2002: Virginia M-Y Lee
Amyloid binding ligands as Alzheimer's disease therapies.
Neurobiology of aging 2002;23(6):1039-42.
2002: Mala V Rao; Linda J Engle; Panaiyur S Mohan; Aidong Yuan; Dike Qiu; Anne M Cataldo; Linda Hassinger; Stephen Jacobsen; Virginia M-Y Lee; Athena Andreadis; Jean-Pierre Julien; Paul C Bridgman; Ralph A. Nixon
Myosin Va binding to neurofilaments is essential for correct myosin Va distribution and transport and neurofilament density.
The Journal of cell biology 2002;159(2):279-90.
2002: John Q Trojanowski; Virginia M-Y Lee
Parkinson's disease and related synucleinopathies are a new class of nervous system amyloidoses.
Neurotoxicology 2002;23(4-5):457-60.
2002: Victoria Zhukareva; Keyur Shah; Kunihiro Uryu; Heiko Braak; Kelly Del Tredici; Sonali Sundarraj; Christopher Clark; John Q Trojanowski; Virginia M-Y Lee
Biochemical analysis of tau proteins in argyrophilic grain disease, Alzheimer's disease, and Pick's disease : a comparative study.
The American journal of pathology 2002;161(4):1135-41.
2002: Parvoneh Poorkaj-Navas; Nancy A Muma; Victoria Zhukareva; Elizabeth J Cochran; Kathleen M Shannon; Howard I Hurtig; William Koller; Thomas D Bird; John Q Trojanowski; Virginia M-Y Lee; Gerard D Schellenberg
An R5L tau mutation in a subject with a progressive supranuclear palsy phenotype.
Annals of neurology 2002;52(4):511-6.
2002: Zhong-Zong Pan; Wendy Bruening; Benoit I Giasson; Virginia M-Y Lee; Andrew K Godwin
Gamma-synuclein promotes cancer cell survival and inhibits stress- and chemotherapy drug-induced apoptosis by modulating MAPK pathways.
The Journal of biological chemistry 2002;277(38):35050-60.
2002: Christina A Wilson; Robert W Doms; Hui Zheng; Virginia M-Y Lee
Presenilins are not required for A beta 42 production in the early secretory pathway.
Nature neuroscience 2002;5(9):849-55.
2002: Mei-Ping Kung; Catherine Hou; Zhi-Ping Zhuang; Daniel M Skovronsky; Bin Zhang; Tamar L Gur; John Q Trojanowski; Virginia M-Y Lee; Hank F Kung
Radioiodinated styrylbenzene derivatives as potential SPECT imaging agents for amyloid plaque detection in Alzheimer's disease.
Journal of molecular neuroscience : MN 2002;19(1-2):7-10.
2002: John E Duda; Benoit I Giasson; Meghann E Mabon; Virginia M-Y Lee; John Q Trojanowski
Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases.
Annals of neurology 2002;52(2):205-10.
2002: Makoto Higuchi; Takeshi Ishihara; Bin Zhang; Ming Hong; Athena Andreadis; John Q Trojanowski; Virginia M-Y Lee
Transgenic mouse model of tauopathies with glial pathology and nervous system degeneration.
Neuron 2002;35(3):433-46.
2002: John Q Trojanowski; Takeshi Ishihara; Makoto Higuchi; Yasumasa Yoshiyama; Ming Hong; Bin Zhang; Mark S Forman; Victoria Zhukareva; Virginia M-Y Lee
Amyotrophic lateral sclerosis/parkinsonism dementia complex: transgenic mice provide insights into mechanisms underlying a common tauopathy in an ethnic minority on Guam.
Experimental neurology 2002;176(1):1-11.
2002: John E Duda; Benoit I Giasson; Meghann E Mabon; Douglas C Miller; Lawrence I Golbe; Virginia M-Y Lee; John Q Trojanowski
Concurrence of alpha-synuclein and tau brain pathology in the Contursi kindred.
Acta neuropathologica 2002;104(1):7-11.
2002: Domenico Pratico'; Kunihiro Uryu; Syuan Sung; Sei Tang; John Q Trojanowski; Virginia M-Y Lee
Aluminum modulates brain amyloidosis through oxidative stress in APP transgenic mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(9):1138-40.
2002: Benoit I Giasson; Harry Ischiropoulos; Virginia M-Y Lee; John Q Trojanowski
The relationship between oxidative/nitrative stress and pathological inclusions in Alzheimer's and Parkinson's diseases.
Free radical biology & medicine 2002;32(12):1264-75.
2002: Victoria Zhukareva; D M A Mann; Stuart Pickering-Brown; Kunihiro Uryu; Theresa Shuck; Keyur Shah; Murray Grossman; Bruce L Miller; Christine M Hulette; Stuart C Feinstein; John Q Trojanowski; Virginia M-Y Lee
Sporadic Pick's disease: a tauopathy characterized by a spectrum of pathological tau isoforms in gray and white matter.
Annals of neurology 2002;51(6):730-9.
2002: Mark S Forman; Victoria Zhukareva; Catherine Bergeron; Steven S Chin; Murray Grossman; Chris Clark; Virginia M-Y Lee; John Q Trojanowski
Signature tau neuropathology in gray and white matter of corticobasal degeneration.
The American journal of pathology 2002;160(6):2045-53.
2002: Domenico Pratico'; Christopher M Clark; Feyan Liun; Joshua Rokach; Virginia M-Y Lee; John Q Trojanowski
Increase of brain oxidative stress in mild cognitive impairment: a possible predictor of Alzheimer disease.
Archives of neurology 2002;59(6):972-6.
2002: Benoit I Giasson; John E Duda; Shawn M Quinn; Bin Zhang; John Q Trojanowski; Virginia M-Y Lee
Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein.
Neuron 2002;34(4):521-33.
2002: Jason Huse; Kangning Liu; Donald Pijak; Dan Carlin; Virginia M-Y Lee; Robert W Doms
Beta-secretase processing in the trans-Golgi network preferentially generates truncated amyloid species that accumulate in Alzheimer's disease brain.
The Journal of biological chemistry 2002;277(18):16278-84.
2002: John Q Trojanowski; Virginia M-Y Lee
The role of tau in Alzheimer's disease.
The Medical clinics of North America 2002;86(3):615-27.
2002: Mark S Forman; M Luise Schmidt; Sanjay Kasturi; Daniel P Perl; Virginia M-Y Lee; John Q Trojanowski
Tau and alpha-synuclein pathology in amygdala of Parkinsonism-dementia complex patients of Guam.
The American journal of pathology 2002;160(5):1725-31.
2002: Alexander R Judkins; Mark S Forman; Kunihiro Uryu; David A Hinkle; Arthur K Asbury; Virginia M-Y Lee; John Q Trojanowski
Co-occurrence of Parkinson's disease with progressive supranuclear palsy.
Acta neuropathologica 2002;103(5):526-30.
2002: PETER NELSON; Douglas Kondziolka; Lawrence R Wechsler; Steven Goldstein; James Gebel; Sharon DeCesare; Elaine Elder; Paul J Zhang; Alan Jacobs; Michael McGrogan; Virginia M-Y Lee; John Q Trojanowski
Clonal human (hNT) neuron grafts for stroke therapy: neuropathology in a patient 27 months after implantation.
The American journal of pathology 2002;160(4):1201-6.
2002: Kangning Liu; Robert W Doms; Virginia M-Y Lee
Glu11 site cleavage and N-terminally truncated A beta production upon BACE overexpression.
Biochemistry 2002;41(9):3128-36.
2002: Thomas W Mitchell; Elliott J Mufson; Julie A Schneider; Elizabeth J Cochran; Jonathan Nissanov; Li-Ying Han; Julia L Bienias; Virginia M-Y Lee; John Q Trojanowski; David A Bennett; Steven E Arnold
Parahippocampal tau pathology in healthy aging, mild cognitive impairment, and early Alzheimer's disease.
Annals of neurology 2002;51(2):182-9.
2002: Pavan K Auluck; H Y Edwin Chan; John Q Trojanowski; Virginia M-Y Lee; Nancy M Bonini
Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease.
Science (New York, N.Y.) 2002;295(5556):865-8.
2002: Kunihiro Uryu; Helmut L Laurer; Tracy McIntosh; Domenico Pratico'; Daniel Martinez; Susan Leight; Virginia M-Y Lee; John Q Trojanowski
Repetitive mild brain trauma accelerates Abeta deposition, lipid peroxidation, and cognitive impairment in a transgenic mouse model of Alzheimer amyloidosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(2):446-54.
2002: Makoto Higuchi; Virginia M-Y Lee; John Q Trojanowski
Tau and axonopathy in neurodegenerative disorders.
Neuromolecular medicine 2002;2(2):131-50.
2002: H Ma; J Zhu; Margaret Maronski; Paul T Kotzbauer; Virginia M-Y Lee; Marc A Dichter; S L Diamond
Non-classical nuclear localization signal peptides for high efficiency lipofection of primary neurons and neuronal cell lines.
Neuroscience 2002;112(1):1-5.
2001: Benoit I Giasson; John E Duda; Mark S Forman; Virginia M-Y Lee; John Q Trojanowski
Prominent perikaryal expression of alpha- and beta-synuclein in neurons of dorsal root ganglion and in medullary neurons.
Experimental neurology 2001;172(2):354-62.
2001: Thomas T Chou; John Q Trojanowski; Virginia M-Y Lee
p38 mitogen-activated protein kinase-independent induction of gadd45 expression in nerve growth factor-induced apoptosis in medulloblastomas.
The Journal of biological chemistry 2001;276(44):41120-7.
2001: Zhi-Ping Zhuang; Mei-Ping Kung; Catherine Hou; Karl Plössl; Daniel M Skovronsky; Tamar L Gur; John Q Trojanowski; Virginia M-Y Lee; Hank F Kung
IBOX(2-(4'-dimethylaminophenyl)-6-iodobenzoxazole): a ligand for imaging amyloid plaques in the brain.
Nuclear medicine and biology 2001;28(8):887-94.
2001: Carol F Lippa; ML Schmidt; Virginia M-Y Lee; John Q Trojanowski
Alpha-synuclein in familial Alzheimer disease: epitope mapping parallels dementia with Lewy bodies and Parkinson disease.
Archives of neurology 2001;58(11):1817-20.
2001: M Luise Schmidt; Victoria Zhukareva; Daniel P Perl; S K Sheridan; Teresa Schuck; Virginia M-Y Lee; John Q Trojanowski
Spinal cord neurofibrillary pathology in Alzheimer disease and Guam Parkinsonism-dementia complex.
Journal of neuropathology and experimental neurology 2001;60(11):1075-86.
2001: Helmut L Laurer; Florence M Bareyre; Virginia M-Y Lee; John Q Trojanowski; Luca Longhi; Rachel Hoover; Kathryn E Saatman; Ramesh Raghupathi; S Hoshino; M Sean Grady; Tracy K McIntosh
Mild head injury increasing the brain's vulnerability to a second concussive impact.
Journal of neurosurgery 2001;95(5):859-70.
2001: Luca Longhi; Kathryn E Saatman; Ramesh Raghupathi; Helmut L Laurer; Philipp M Lenzlinger; Peter Riess; Edmund A M Neugebauer; John Q Trojanowski; Virginia M-Y Lee; M Sean Grady; DI Graham; Tracy K McIntosh
A review and rationale for the use of genetically engineered animals in the study of traumatic brain injury.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2001;21(11):1241-58.
2001: Evgenia Paxinou; Q Chen; M Weisse; Benoit I Giasson; Erin H Norris; S M Rueter; John Q Trojanowski; Virginia M-Y Lee; Harry Ischiropoulos
Induction of alpha-synuclein aggregation by intracellular nitrative insult.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(20):8053-61.
2001: Paul T Kotzbauer; J Q Trojanowsk; Virginia M-Y Lee
Lewy body pathology in Alzheimer's disease.
Journal of molecular neuroscience : MN 2001;17(2):225-32.
2001: Daniel M Skovronsky; S Fath; Virginia M-Y Lee; Marcos E Milla
Neuronal localization of the TNFalpha converting enzyme (TACE) in brain tissue and its correlation to amyloid plaques.
Journal of neurobiology 2001;49(1):40-6.
2001: Benoit I Giasson; Virginia M-Y Lee
Parkin and the molecular pathways of Parkinson's disease.
Neuron 2001;31(6):885-8.
2001: Yasumasa Yoshiyama; Virginia M-Y Lee; John Q Trojanowski
Frontotemporal dementia and tauopathy.
Current neurology and neuroscience reports 2001;1(5):413-21.
2001: M Luise Schmidt; Teresa Schuck; S Sheridan; Mei-Ping Kung; H Kung; Zhi-Ping Zhuang; Catherine Bergeron; J S Lamarche; Daniel M Skovronsky; Benoit I Giasson; Virginia M-Y Lee; John Q Trojanowski
The fluorescent Congo red derivative, (trans, trans)-1-bromo-2,5-bis-(3-hydroxycarbonyl-4-hydroxy)styrylbenzene (BSB), labels diverse beta-pleated sheet structures in postmortem human neurodegenerative disease brains.
The American journal of pathology 2001;159(3):937-43.
2001: Virginia M-Y Lee
Biomedicine. Tauists and beta-aptists united--well almost!
Science (New York, N.Y.) 2001;293(5534):1446-7.
2001: Takeshi Ishihara; Makoto Higuchi; Bin Zhang; Yasumasa Yoshiyama; Ming Hong; John Q Trojanowski; Virginia M-Y Lee
Attenuated neurodegenerative disease phenotype in tau transgenic mouse lacking neurofilaments.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(16):6026-35.
2001: Virginia M-Y Lee
Abeta immunization: moving Abeta peptide from brain to blood.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(16):8931-2.
2001: Chi-Wan Lee; Zhi-Ping Zhuang; Mei-Ping Kung; Karl Plössl; Daniel M Skovronsky; Tamar L Gur; Catherine Hou; John Q Trojanowski; Virginia M-Y Lee; Hank F Kung
Isomerization of (Z,Z) to (E,E)1-bromo-2,5-bis-(3-hydroxycarbonyl-4-hydroxy)styrylbenzene in strong base: probes for amyloid plaques in the brain.
Journal of medicinal chemistry 2001;44(14):2270-5.
2001: Domenico Pratico'; Kunihiro Uryu; Susan Leight; J Q Trojanoswki; Virginia M-Y Lee
Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(12):4183-7.
2001: Yong Shen; Lih-Fen Lue; L Yang; Alex Roher; Y Kuo; R Strohmeyer; W J Goux; Virginia M-Y Lee; Gail Johnson; S D Webster; N R Cooper; Bonnie M Bradt; Joseph Rogers
Complement activation by neurofibrillary tangles in Alzheimer's disease.
Neuroscience letters 2001;305(3):165-8.
2001: Zhi-Ping Zhuang; Mei-Ping Kung; Catherine Hou; Daniel M Skovronsky; Tamar L Gur; Karl Plössl; John Q Trojanowski; Virginia M-Y Lee; Hank F Kung
Radioiodinated styrylbenzenes and thioflavins as probes for amyloid aggregates.
Journal of medicinal chemistry 2001;44(12):1905-14.
2001: M Shafiq; Linda E Nee; J Grafman; N Tresser; Virginia M-Y Lee; John Q Trojanowski; Carol F Lippa
Frontotemporal dementia: report of a familial case.
Neurology 2001;56(11 Suppl 4):S31-4.
2001: Virginia M-Y Lee; John Q Trojanowski
Transgenic mouse models of tauopathies: prospects for animal models of Pick's disease.
Neurology 2001;56(11 Suppl 4):S26-30.
2001: Daniel M Skovronsky; Virginia M-Y Lee; Domenico Pratico'
Amyloid precursor protein and amyloid beta peptide in human platelets. Role of cyclooxygenase and protein kinase C.
The Journal of biological chemistry 2001;276(20):17036-43.
2001: M Luise Schmidt; Victoria Zhukareva; K L Newell; Virginia M-Y Lee; John Q Trojanowski
Tau isoform profile and phosphorylation state in dementia pugilistica recapitulate Alzheimer's disease.
Acta neuropathologica 2001;101(5):518-24.
2001: Vanessa Vogelsberg-Ragaglia; Teresa Schuck; John Q Trojanowski; Virginia M-Y Lee
PP2A mRNA expression is quantitatively decreased in Alzheimer's disease hippocampus.
Experimental neurology 2001;168(2):402-12.
2001: James E Galvin; T M Schuck; Virginia M-Y Lee; John Q Trojanowski
Differential expression and distribution of alpha-, beta-, and gamma-synuclein in the developing human substantia nigra.
Experimental neurology 2001;168(2):347-55.
2001: Victoria Zhukareva; Vanessa Vogelsberg-Ragaglia; Vivianna M Van Deerlin; J Bruce; T Shuck; Murray Grossman; Christopher M Clark; Steven E Arnold; Eliezer Masliah; Douglas Galasko; John Q Trojanowski; Virginia M-Y Lee
Loss of brain tau defines novel sporadic and familial tauopathies with frontotemporal dementia.
Annals of neurology 2001;49(2):165-75.
2001: James E Galvin; Virginia M-Y Lee; John Q Trojanowski
Synucleinopathies: clinical and pathological implications.
Archives of neurology 2001;58(2):186-90.
2001: Takeshi Ishihara; Bin Zhang; Makoto Higuchi; Yasumasa Yoshiyama; John Q Trojanowski; Virginia M-Y Lee
Age-dependent induction of congophilic neurofibrillary tau inclusions in tau transgenic mice.
The American journal of pathology 2001;158(2):555-62.
2001: Benoit I Giasson; Ian V J Murray; John Q Trojanowski; Virginia M-Y Lee
A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly.
The Journal of biological chemistry 2001;276(4):2380-6.
2001: Virginia M-Y Lee; Michel Goedert; John Q Trojanowski
Neurodegenerative tauopathies.
Annual review of neuroscience 2001;24():1121-59.
2001: Serge Przedborski; Q Chen; Miquel Vila; Benoit I Giasson; R Djaldatti; S Vukosavic; José M Souza; Vernice Jackson-Lewis; Virginia M-Y Lee; Harry Ischiropoulos
Oxidative post-translational modifications of alpha-synuclein in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease.
Journal of neurochemistry 2001;76(2):637-40.
2001: Garth F Hall; Virginia M-Y Lee; Gloria Lee; Jun Yao
Staging of neurofibrillary degeneration caused by human tau overexpression in a unique cellular model of human tauopathy.
The American journal of pathology 2001;158(1):235-46.
2000: Mark S Forman; Virginia M-Y Lee; John Q Trojanowski
New insights into genetic and molecular mechanisms of brain degeneration in tauopathies.
Journal of chemical neuroanatomy 2000;20(3-4):225-44.
2000: Carol F Lippa; Victoria Zhukareva; T Kawarai; Kunihiro Uryu; M Shafiq; Linda E Nee; J Grafman; Y Liang; Peter St George-Hyslop; John Q Trojanowski; Virginia M-Y Lee
Frontotemporal dementia with novel tau pathology and a Glu342Val tau mutation.
Annals of neurology 2000;48(6):850-8.
2000: Vanessa Vogelsberg-Ragaglia; J Bruce; Christiane Richter-Landsberg; B Zhang; M Hong; John Q Trojanowski; Virginia M-Y Lee
Distinct FTDP-17 missense mutations in tau produce tau aggregates and other pathological phenotypes in transfected CHO cells.
Molecular biology of the cell 2000;11(12):4093-104.
2000: Thomas W Mitchell; Jonathan Nissanov; Li-Ying Han; Elliott J Mufson; Julie A Schneider; Elizabeth J Cochran; David A Bennett; Virginia M-Y Lee; John Q Trojanowski; Steven E Arnold
Novel method to quantify neuropil threads in brains from elders with or without cognitive impairment.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2000;48(12):1627-38.
2000: Benoit I Giasson; Virginia M-Y Lee
A new link between pesticides and Parkinson's disease.
Nature neuroscience 2000;3(12):1227-8.
2000: M Luise Schmidt; R Garruto; J Chen; Virginia M-Y Lee; John Q Trojanowski
Tau epitopes in spinal cord neurofibrillary lesions in Chamorros of Guam.
Neuroreport 2000;11(16):3427-30.
2000: Benoit I Giasson; John E Duda; Ian V J Murray; Q Chen; José M Souza; Howard I Hurtig; Harry Ischiropoulos; John Q Trojanowski; Virginia M-Y Lee
Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions.
Science (New York, N.Y.) 2000;290(5493):985-9.
2000: Domenico Pratico'; Christopher M Clark; Virginia M-Y Lee; John Q Trojanowski; Joshua Rokach; garret fitzgerald
Increased 8,12-iso-iPF2alpha-VI in Alzheimer's disease: correlation of a noninvasive index of lipid peroxidation with disease severity.
Annals of neurology 2000;48(5):809-12.
2000: John E Duda; Benoit I Giasson; Q Chen; Tamar L Gur; Howard I Hurtig; Matthew B Stern; SM Gollomp; Harry Ischiropoulos; Virginia M-Y Lee; John Q Trojanowski
Widespread nitration of pathological inclusions in neurodegenerative synucleinopathies.
The American journal of pathology 2000;157(5):1439-45.
2000: Jason Huse; Donald Pijak; G J Leslie; Virginia M-Y Lee; Robert W Doms
Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease beta-secretase.
The Journal of biological chemistry 2000;275(43):33729-37.
2000: Christiane Richter-Landsberg; M Gorath; John Q Trojanowski; Virginia M-Y Lee
alpha-synuclein is developmentally expressed in cultured rat brain oligodendrocytes.
Journal of neuroscience research 2000;62(1):9-14.
2000: John E Duda; Benoit I Giasson; Tamar L Gur; Thomas J Montine; David Robertson; I Biaggioni; Howard I Hurtig; Matthew B Stern; SM Gollomp; Murray Grossman; Virginia M-Y Lee; John Q Trojanowski
Immunohistochemical and biochemical studies demonstrate a distinct profile of alpha-synuclein permutations in multiple system atrophy.
Journal of neuropathology and experimental neurology 2000;59(9):830-41.
2000: James E Galvin; M Nakamura; Tracy K McIntosh; Kathryn E Saatman; D Sampathu; Ramesh Raghupathi; Virginia M-Y Lee; John Q Trojanowski
Neurofilament-rich intraneuronal inclusions exacerbate neurodegenerative sequelae of brain trauma in NFH/LacZ transgenic mice.
Experimental neurology 2000;165(1):77-89.
2000: James E Galvin; Benoit I Giasson; Howard I Hurtig; Virginia M-Y Lee; John Q Trojanowski
Neurodegeneration with brain iron accumulation, type 1 is characterized by alpha-, beta-, and gamma-synuclein neuropathology.
The American journal of pathology 2000;157(2):361-8.
2000: John E Duda; Virginia M-Y Lee; John Q Trojanowski
Neuropathology of synuclein aggregates.
Journal of neuroscience research 2000;61(2):121-7.
2000: Stephen D. Ginsberg; Scott Hemby; Virginia M-Y Lee; james eberwine; John Q Trojanowski
Expression profile of transcripts in Alzheimer's disease tangle-bearing CA1 neurons.
Annals of neurology 2000;48(1):77-87.
2000: Konrad Talbot; Robert A Young; C Jolly-Tornetta; Virginia M-Y Lee; John Q Trojanowski; Bryan A Wolf
A frontal variant of Alzheimer's disease exhibits decreased calcium-independent phospholipase A2 activity in the prefrontal cortex.
Neurochemistry international 2000;37(1):17-31.
2000: Daniel M Skovronsky; Bin Zhang; Mei-Ping Kung; Hank F Kung; John Q Trojanowski; Virginia M-Y Lee
In vivo detection of amyloid plaques in a mouse model of Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(13):7609-14.
2000: José M Souza; Benoit I Giasson; Q Chen; Virginia M-Y Lee; Harry Ischiropoulos
Dityrosine cross-linking promotes formation of stable alpha -synuclein polymers. Implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies.
The Journal of biological chemistry 2000;275(24):18344-9.
2000: Andrew J Gow; Q Chen; M Gole; Marios Themistocleous; Virginia M-Y Lee; Harry Ischiropoulos
Two distinct mechanisms of nitric oxide-mediated neuronal cell death show thiol dependency.
American journal of physiology. Cell physiology 2000;278(6):C1099-107.
2000: José M Souza; Benoit I Giasson; Virginia M-Y Lee; Harry Ischiropoulos
Chaperone-like activity of synucleins.
FEBS letters 2000;474(1):116-9.
2000: Howard I Hurtig; John Q Trojanowski; James E Galvin; Douglas C Ewbank; M Luise Schmidt; Virginia M-Y Lee; Christopher M Clark; Guila Glosser; Matthew B Stern; SM Gollomp; Steven E Arnold
Alpha-synuclein cortical Lewy bodies correlate with dementia in Parkinson's disease.
Neurology 2000;54(10):1916-21.
2000: Wendy Bruening; Benoit I Giasson; Andres J P Klein-Szanto; Virginia M-Y Lee; John Q Trojanowski; Andrew K Godwin
Synucleins are expressed in the majority of breast and ovarian carcinomas and in preneoplastic lesions of the ovary.
Cancer 2000;88(9):2154-63.
2000: Alphonse Probst; Jürgen Götz; Karl-Heinz Wiederhold; Markus Tolnay; C Mistl; Anne-Lise Jaton; M Hong; T Ishihara; Virginia M-Y Lee; John Q Trojanowski; Ross Jakes; R Anthony Crowther; Maria Grazia Spillantini; Kurt Bürki; Michel Goedert
Axonopathy and amyotrophy in mice transgenic for human four-repeat tau protein.
Acta neuropathologica 2000;99(5):469-81.
2000: Daniel M Skovronsky; Virginia M-Y Lee
Beta-secretase revealed: starting gate for race to novel therapies for Alzheimer's disease.
Trends in pharmacological sciences 2000;21(5):161-3.
2000: Y Nakagawa; L Reed; M Nakamura; Tracy K McIntosh; Douglas H Smith; Kathryn E Saatman; Ramesh Raghupathi; J Clemens; Takaomi C Saido; Virginia M-Y Lee; John Q Trojanowski
Brain trauma in aged transgenic mice induces regression of established abeta deposits.
Experimental neurology 2000;163(1):244-52.
2000: D D Murphy; Susan M Rueter; John Q Trojanowski; Virginia M-Y Lee
Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(9):3214-20.
2000: Angelika Eggert; Naohiko Ikegaki; X Liu; TT Chou; Virginia M-Y Lee; John Q Trojanowski; Garrett M Brodeur
Molecular dissection of TrkA signal transduction pathways mediating differentiation in human neuroblastoma cells.
Oncogene 2000;19(16):2043-51.
2000: Michael A Grotzer; Anna Janss; K Fung; Jaclyn A Biegel; Leslie N Sutton; Lucy B Rorke; Huaqing Zhao; Avital Cnaan; Peter C Phillips; Virginia M-Y Lee; John Q Trojanowski
TrkC expression predicts good clinical outcome in primitive neuroectodermal brain tumors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2000;18(5):1027-35.
2000: Benoit I Giasson; Ross Jakes; Michel Goedert; John E Duda; Susan Leight; John Q Trojanowski; Virginia M-Y Lee
A panel of epitope-specific antibodies detects protein domains distributed throughout human alpha-synuclein in Lewy bodies of Parkinson's disease.
Journal of neuroscience research 2000;59(4):528-33.
2000: Daniel M Skovronsky; Donald Pijak; Robert W Doms; Virginia M-Y Lee
A distinct ER/IC gamma-secretase competes with the proteasome for cleavage of APP.
Biochemistry 2000;39(4):810-7.
2000: Daniel M Skovronsky; D B Moore; Marcos E Milla; Robert W Doms; Virginia M-Y Lee
Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the trans-golgi network.
The Journal of biological chemistry 2000;275(4):2568-75.
2000: Carol F Lippa; ML Schmidt; Linda E Nee; Thomas D Bird; David Nochlin; Christine M Hulette; Hiroshi Mori; Virginia M-Y Lee; John Q Trojanowski
AMY plaques in familial AD: comparison with sporadic Alzheimer's disease.
Neurology 2000;54(1):100-4.
2000: Thomas T Chou; John Q Trojanowski; Virginia M-Y Lee
A novel apoptotic pathway induced by nerve growth factor-mediated TrkA activation in medulloblastoma.
The Journal of biological chemistry 2000;275(1):565-70.
2000: Daniel M Skovronsky; Jiongjiong Wang; Virginia M-Y Lee; Robert W Doms
Quantifying Aβ(1-40) and Aβ (1-42) Using Sandwich-ELISA.
Methods in molecular medicine 2000;32():79-89.
2000: John Q Trojanowski; Virginia M-Y Lee
"Fatal attractions" of proteins. A comprehensive hypothetical mechanism underlying Alzheimer's disease and other neurodegenerative disorders.
Annals of the New York Academy of Sciences 2000;924():62-7.
2000: Virginia M-Y Lee; R S Hartley; John Q Trojanowski
Neurobiology of human neurons (NT2N) grafted into mouse spinal cord: implications for improving therapy of spinal cord injury.
Progress in brain research 2000;128():299-307.
2000: Christine M Coughlan; CM McManus; Matthew Sharron; Z Gao; D Murphy; Salman Jaffer; W Choe; Wei Chen; Joseph Hesselgesser; H Gaylord; A Kalyuzhny; Virginia M-Y Lee; B Wolf; Robert W Doms; Dennis L Kolson
Expression of multiple functional chemokine receptors and monocyte chemoattractant protein-1 in human neurons.
Neuroscience 2000;97(3):591-600.
1999: R S Hartley; John Q Trojanowski; Virginia M-Y Lee
Differential effects of spinal cord gray and white matter on process outgrowth from grafted human NTERA2 neurons (NT2N, hNT).
The Journal of comparative neurology 1999;415(3):404-18.
1999: John E Duda; U Shah; Steven E Arnold; Virginia M-Y Lee; John Q Trojanowski
The expression of alpha-, beta-, and gamma-synucleins in olfactory mucosa from patients with and without neurodegenerative diseases.
Experimental neurology 1999;160(2):515-22.
1999: M Luise Schmidt; Takaomi C Saido; Virginia M-Y Lee; John Q Trojanowski
Spatial relationship of AMY protein deposits and different species of Abeta peptides in amyloid plaques of the Alzheimer disease brain.
Journal of neuropathology and experimental neurology 1999;58(12):1227-33.
1999: James E Galvin; Kunihiro Uryu; Virginia M-Y Lee; John Q Trojanowski
Axon pathology in Parkinson's disease and Lewy body dementia hippocampus contains alpha-, beta-, and gamma-synuclein.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(23):13450-5.
1999: Salvador Soriano; A S Chyung; X Chen; Gorazd B Stokin; Virginia M-Y Lee; Edward H Koo
Expression of beta-amyloid precursor protein-CD3gamma chimeras to demonstrate the selective generation of amyloid beta(1-40) and amyloid beta(1-42) peptides within secretory and endocytic compartments.
The Journal of biological chemistry 1999;274(45):32295-300.
1999: John Q Trojanowski; C M Clark; Hiroyuki Arai; Virginia M-Y Lee
Elevated levels of tau in cerebrospinal fluid: implications for the antemortem diagnosis of Alzheimer's disease elevated levels of tau in cerebrospinal fluid: implications for the antemortem diagnosis of Alzheimer's disease.
Journal of Alzheimer's disease : JAD 1999;1(4-5):297-305.
1999: Takeshi Ishihara; Ming Hong; Bin Zhang; Y Nakagawa; Michael K Lee; John Q Trojanowski; Virginia M-Y Lee
Age-dependent emergence and progression of a tauopathy in transgenic mice overexpressing the shortest human tau isoform.
Neuron 1999;24(3):751-62.
1999: Virginia M-Y Lee; John Q Trojanowski
Neurodegenerative tauopathies: human disease and transgenic mouse models.
Neuron 1999;24(3):507-10.
1999: Atsuko Uchida; Hiroshi Yorifuji; Virginia M-Y Lee; Takeo Kishimoto; Shin-ichi Hisanaga
Neurofilaments of aged rats: the strengthened interneurofilament interaction and the reduced amount of NF-M.
Journal of neuroscience research 1999;58(2):337-48.
1999: John Q Trojanowski; Virginia M-Y Lee
Transgenic models of tauopathies and synucleinopathies.
Brain pathology (Zurich, Switzerland) 1999;9(4):733-9.
1999: Douglas H Smith; Xiao-Han Chen; Masahiro Nonaka; John Q Trojanowski; Virginia M-Y Lee; Kathryn E Saatman; Matthew J Leoni; BN Xu; John A Wolf; David F Meaney
Accumulation of amyloid beta and tau and the formation of neurofilament inclusions following diffuse brain injury in the pig.
Journal of neuropathology and experimental neurology 1999;58(9):982-92.
1999: Scott T Brady; AS Witt; L L Kirkpatrick; S M de Waegh; C Readhead; Pang-hsien Tu; Virginia M-Y Lee
Formation of compact myelin is required for maturation of the axonal cytoskeleton.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(17):7278-88.
1999: Y Nakagawa; M Nakamura; Tracy K McIntosh; Aurelio Rodriguez; J A Berlin; Douglas H Smith; Kathryn E Saatman; Ramesh Raghupathi; J Clemens; Takaomi C Saido; M Luise Schmidt; Virginia M-Y Lee; John Q Trojanowski
Traumatic brain injury in young, amyloid-beta peptide overexpressing transgenic mice induces marked ipsilateral hippocampal atrophy and diminished Abeta deposition during aging.
The Journal of comparative neurology 1999;411(3):390-8.
1999: Stephen D. Ginsberg; James E Galvin; Virginia M-Y Lee; Lucy B Rorke; dennis dickson; John H Wolfe; M Z Jones; John Q Trojanowski
Accumulation of intracellular amyloid-beta peptide (A beta 1-40) in mucopolysaccharidosis brains.
Journal of neuropathology and experimental neurology 1999;58(8):815-24.
1999: C A Wilson; Robert W Doms; Virginia M-Y Lee
Intracellular APP processing and A beta production in Alzheimer disease.
Journal of neuropathology and experimental neurology 1999;58(8):787-94.
1999: J Wang; dennis dickson; John Q Trojanowski; Virginia M-Y Lee
The levels of soluble versus insoluble brain Abeta distinguish Alzheimer's disease from normal and pathologic aging.
Experimental neurology 1999;158(2):328-37.
1999: Ross Jakes; R Anthony Crowther; Virginia M-Y Lee; John Q Trojanowski; Takeshi Iwatsubo; Michel Goedert
Epitope mapping of LB509, a monoclonal antibody directed against human alpha-synuclein.
Neuroscience letters 1999;269(1):13-6.
1999: Gregory A Elder; Victor L Friedrich; D Pereira; Pang-hsien Tu; B Zhang; Virginia M-Y Lee; Robert A Lazzarini
Mice with disrupted midsized and heavy neurofilament genes lack axonal neurofilaments but have unaltered numbers of axonal microtubules.
Journal of neuroscience research 1999;57(1):23-32.
1999: Ziad S Nasreddine; M Loginov; LN Clark; J Lamarche; Bruce L Miller; A Lamontagne; Victoria Zhukareva; Virginia M-Y Lee; Kirk Wilhelmsen; Daniel Geschwind
From genotype to phenotype: a clinical pathological, and biochemical investigation of frontotemporal dementia and parkinsonism (FTDP-17) caused by the P301L tau mutation.
Annals of neurology 1999;45(6):704-15.
1999: Douglas H Smith; John A Wolf; Theresa A Lusardi; Virginia M-Y Lee; David F Meaney
High tolerance and delayed elastic response of cultured axons to dynamic stretch injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(11):4263-9.
1999: Ian D'Souza; Parvoneh Poorkaj-Navas; M Hong; David Nochlin; Virginia M-Y Lee; Thomas D Bird; Gerard D Schellenberg
Missense and silent tau gene mutations cause frontotemporal dementia with parkinsonism-chromosome 17 type, by affecting multiple alternative RNA splicing regulatory elements.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(10):5598-603.
1999: Judith K Muir; Ramesh Raghupathi; Kathryn E Saatman; C A Wilson; Virginia M-Y Lee; John Q Trojanowski; MF Philips; Tracy K McIntosh
Terminally differentiated human neurons survive and integrate following transplantation into the traumatically injured rat brain.
Journal of neurotrauma 1999;16(5):403-14.
1999: R S Hartley; Michael Margulis; Paul S Fishman; Virginia M-Y Lee; Cha-Min Tang
Functional synapses are formed between human NTera2 (NT2N, hNT) neurons grown on astrocytes.
The Journal of comparative neurology 1999;407(1):1-10.
1999: Benoit I Giasson; Kunihiro Uryu; John Q Trojanowski; Virginia M-Y Lee
Mutant and wild type human alpha-synucleins assemble into elongated filaments with distinct morphologies in vitro.
The Journal of biological chemistry 1999;274(12):7619-22.
1999: Carol F Lippa; ML Schmidt; Virginia M-Y Lee; John Q Trojanowski
Dementia with Lewy bodies.
Neurology 1999;52(4):893.
1999: Carol F Lippa; ML Schmidt; Virginia M-Y Lee; John Q Trojanowski
Antibodies to alpha-synuclein detect Lewy bodies in many Down's syndrome brains with Alzheimer's disease.
Annals of neurology 1999;45(3):353-7.
1999: M Iijima; Takeshi Tabira; Parvoneh Poorkaj-Navas; Gerard D Schellenberg; John Q Trojanowski; Virginia M-Y Lee; M L Schmidt; K Takahashi; T Nabika; T Matsumoto; Y Yamashita; S Yoshioka; H Ishino
A distinct familial presenile dementia with a novel missense mutation in the tau gene.
Neuroreport 1999;10(3):497-501.
1999: Stephen D. Ginsberg; Peter B Crino; Scott Hemby; J A Weingarten; Virginia M-Y Lee; james eberwine; John Q Trojanowski
Predominance of neuronal mRNAs in individual Alzheimer's disease senile plaques.
Annals of neurology 1999;45(2):174-81.
1999: Virginia M-Y Lee; J Wang; John Q Trojanowski
Purification of paired helical filament tau and normal tau from human brain tissue.
Methods in enzymology 1999;309():81-9.
1999: MF Philips; Judith K Muir; Kathryn E Saatman; Ramesh Raghupathi; Virginia M-Y Lee; John Q Trojanowski; Tracy K McIntosh
Survival and integration of transplanted postmitotic human neurons following experimental brain injury in immunocompetent rats.
Journal of neurosurgery 1999;90(1):116-24.
1999: James E Galvin; Virginia M-Y Lee; M Luise Schmidt; Pang-hsien Tu; Takeshi Iwatsubo; John Q Trojanowski
Pathobiology of the Lewy body.
Advances in neurology 1999;80():313-24.
1998: M Hong; Victoria Zhukareva; Vanessa Vogelsberg-Ragaglia; Zbigniew K Wszolek; L Reed; Bruce L Miller; Daniel Geschwind; Thomas D Bird; Daniel W McKeel; Alison Goate; John C Morris; Kirk Wilhelmsen; Gerard D Schellenberg; John Q Trojanowski; Virginia M-Y Lee
Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17.
Science (New York, N.Y.) 1998;282(5395):1914-7.
1998: Cesario Borlongan; Y Tajima; John Q Trojanowski; Virginia M-Y Lee; Paul Sanberg
Cerebral ischemia and CNS transplantation: differential effects of grafted fetal rat striatal cells and human neurons derived from a clonal cell line.
Neuroreport 1998;9(16):3703-9.
1998: Stephen D. Ginsberg; James E Galvin; T S Chiu; Virginia M-Y Lee; Eliezer Masliah; John Q Trojanowski
RNA sequestration to pathological lesions of neurodegenerative diseases.
Acta neuropathologica 1998;96(5):487-94.
1998: R Hosoda; Takaomi C Saido; L Otvos; T Arai; D M A Mann; Virginia M-Y Lee; John Q Trojanowski; Takeshi Iwatsubo
Quantification of modified amyloid beta peptides in Alzheimer disease and Down syndrome brains.
Journal of neuropathology and experimental neurology 1998;57(11):1089-95.
1998: Carol F Lippa; H Fujiwara; D M A Mann; Benoit I Giasson; M Baba; ML Schmidt; Linda E Nee; B O'Connell; Daniel A Pollen; Peter St George-Hyslop; Bernardino Ghetti; David Nochlin; Thomas D Bird; Nigel J Cairns; Virginia M-Y Lee; Takeshi Iwatsubo; John Q Trojanowski
Lewy bodies contain altered alpha-synuclein in brains of many familial Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes.
The American journal of pathology 1998;153(5):1365-70.
1998: LN Clark; Parvoneh Poorkaj-Navas; Zbigniew K Wszolek; Daniel Geschwind; Ziad S Nasreddine; Bruce L Miller; D Li; Haydeh Payami; F Awert; Katerina Markopoulou; A Andreadis; Ian D'Souza; Virginia M-Y Lee; L Reed; John Q Trojanowski; Victoria Zhukareva; Thomas D Bird; Gerard D Schellenberg; Kirk Wilhelmsen
Pathogenic implications of mutations in the tau gene in pallido-ponto-nigral degeneration and related neurodegenerative disorders linked to chromosome 17.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(22):13103-7.
1998: Gregory A Elder; Victor L Friedrich; C Kang; P Bosco; A Gourov; Pang-hsien Tu; B Zhang; Virginia M-Y Lee; Robert A Lazzarini
Requirement of heavy neurofilament subunit in the development of axons with large calibers.
The Journal of cell biology 1998;143(1):195-205.
1998: John Q Trojanowski; Michel Goedert; Takeshi Iwatsubo; Virginia M-Y Lee
Fatal attractions: abnormal protein aggregation and neuron death in Parkinson's disease and Lewy body dementia.
Cell death and differentiation 1998;5(10):832-7.
1998: Pang-hsien Tu; James E Galvin; M Baba; Benoit I Giasson; Taisuke Tomita; Susan Leight; S Nakajo; Takeshi Iwatsubo; John Q Trojanowski; Virginia M-Y Lee
Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble alpha-synuclein.
Annals of neurology 1998;44(3):415-22.
1998: Douglas H Smith; M Nakamura; Tracy K McIntosh; J Wang; A Rodríguez; Xiao-Han Chen; Ramesh Raghupathi; Kathryn E Saatman; J Clemens; M Luise Schmidt; Virginia M-Y Lee; John Q Trojanowski
Brain trauma induces massive hippocampal neuron death linked to a surge in beta-amyloid levels in mice overexpressing mutant amyloid precursor protein.
The American journal of pathology 1998;153(3):1005-10.
1998: T K McIntosh; Kathryn E Saatman; Ramesh Raghupathi; D I Graham; D H Smith; Virginia M-Y Lee; John Q Trojanowski
The Dorothy Russell Memorial Lecture. The molecular and cellular sequelae of experimental traumatic brain injury: pathogenetic mechanisms.
Neuropathology and applied neurobiology 1998;24(4):251-67.
1998: ZY Gao; M Chen; Heather W Collins; Franz M Matschinsky; Virginia M-Y Lee; Bryan A Wolf
Mechanisms of spontaneous cytosolic Ca2+ transients in differentiated human neuronal cells.
The European journal of neuroscience 1998;10(7):2416-25.
1998: ZY Gao; G Xu; Magdalena M Stwora-Wojczyk; Franz M Matschinsky; Virginia M-Y Lee; Bryan A Wolf
Retinoic acid induction of calcium channel expression in human NT2N neurons.
Biochemical and biophysical research communications 1998;247(2):407-13.
1998: LA Reed; M Luise Schmidt; Zbigniew K Wszolek; Brian J Balin; V Soontornniyomkij; Virginia M-Y Lee; John Q Trojanowski; RL Schelper
The neuropathology of a chromosome 17-linked autosomal dominant parkinsonism and dementia ("pallido-ponto-nigral degeneration").
Journal of neuropathology and experimental neurology 1998;57(6):588-601.
1998: C Jolly-Tornetta; ZY Gao; Virginia M-Y Lee; Bryan A Wolf
Regulation of amyloid precursor protein secretion by glutamate receptors in human Ntera 2 neurons.
The Journal of biological chemistry 1998;273(22):14015-21.
1998: Daniel M Skovronsky; Robert W Doms; Virginia M-Y Lee
Detection of a novel intraneuronal pool of insoluble amyloid beta protein that accumulates with time in culture.
The Journal of cell biology 1998;141(4):1031-9.
1998: Gregory A Elder; Victor L Friedrich; P Bosco; C Kang; A Gourov; Pang-hsien Tu; Virginia M-Y Lee; Robert A Lazzarini
Absence of the mid-sized neurofilament subunit decreases axonal calibers, levels of light neurofilament (NF-L), and neurofilament content.
The Journal of cell biology 1998;141(3):727-39.
1998: Y Tajima; R P Molina; Lucy B Rorke; D R Kaplan; Monte J Radeke; S C Feinstein; Virginia M-Y Lee; John Q Trojanowski
Neurotrophins and neuronal versus glial differentiation in medulloblastomas and other pediatric brain tumors.
Acta neuropathologica 1998;95(4):325-32.
1998: GS Smutzer; Virginia M-Y Lee; John Q Trojanowski; Steven E Arnold
Human olfactory mucosa in schizophrenia.
The Annals of otology, rhinology, and laryngology 1998;107(4):349-55.
1998: Valerie Askanas; W King Engel; CC Yang; RB Alvarez; Virginia M-Y Lee; Thomas Wisniewski
Light and electron microscopic immunolocalization of presenilin 1 in abnormal muscle fibers of patients with sporadic inclusion-body myositis and autosomal-recessive inclusion-body myopathy.
The American journal of pathology 1998;152(4):889-95.
1998: M Baba; S Nakajo; Pang-hsien Tu; Taisuke Tomita; K Nakaya; Virginia M-Y Lee; John Q Trojanowski; Takeshi Iwatsubo
Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.
The American journal of pathology 1998;152(4):879-84.
1998: ZY Gao; Heather W Collins; Franz M Matschinsky; Virginia M-Y Lee; Bryan A Wolf
Cytotoxic effect of beta-amyloid on a human differentiated neuron is not mediated by cytoplasmic Ca2+ accumulation.
Journal of neurochemistry 1998;70(4):1394-400.
1998: H Murai; JE Pierce; Ramesh Raghupathi; Douglas H Smith; Kathryn E Saatman; John Q Trojanowski; Virginia M-Y Lee; Jeanne F Loring; Christopher B Eckman; Steven G Younkin; Tracy K McIntosh
Twofold overexpression of human beta-amyloid precursor proteins in transgenic mice does not affect the neuromotor, cognitive, or neurodegenerative sequelae following experimental brain injury.
The Journal of comparative neurology 1998;392(4):428-38.
1998: Xinghua Yin; Thomas Crawford; John W Griffin; P h Tu; Virginia M-Y Lee; C Li; J Roder; Bruce D Trapp
Myelin-associated glycoprotein is a myelin signal that modulates the caliber of myelinated axons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(6):1953-62.
1998: Hiroyuki Arai; C M Clark; D C Ewbank; S Takase; S Higuchi; M Miura; H Seki; M Higuchi; Toshifumi Matsui; Virginia M-Y Lee; John Q Trojanowski; Hidetada Sasaki
Cerebrospinal fluid tau protein as a potential diagnostic marker in Alzheimer's disease.
Neurobiology of aging 1998;19(2):125-6.
1998: Santosh kesari; TM Lasner; K R Balsara; BP Randazzo; Virginia M-Y Lee; John Q Trojanowski; Nigel W Fraser
A neuroattenuated ICP34.5-deficient herpes simplex virus type 1 replicates in ependymal cells of the murine central nervous system.
The Journal of general virology 1998;79 ( Pt 3)():525-36.
1998: Jason C Mills; Virginia M-Y Lee; Randall N Pittman
Activation of a PP2A-like phosphatase and dephosphorylation of tau protein characterize onset of the execution phase of apoptosis.
Journal of cell science 1998;111 ( Pt 5)():625-36.
1998: TM Lasner; R Tal-Singer; Santosh kesari; Virginia M-Y Lee; John Q Trojanowski; Nigel W Fraser
Toxicity and neuronal infection of a HSV-1 ICP34.5 mutant in nude mice.
Journal of neurovirology 1998;4(1):100-5.
1998: Cesario Borlongan; Y Tajima; John Q Trojanowski; Virginia M-Y Lee; Paul Sanberg
Transplantation of cryopreserved human embryonal carcinoma-derived neurons (NT2N cells) promotes functional recovery in ischemic rats.
Experimental neurology 1998;149(2):310-21.
1998: M Luise Schmidt; Virginia M-Y Lee; Takaomi C Saido; Daniel P Perl; Teresa Schuck; Takeshi Iwatsubo; John Q Trojanowski
Amyloid plaques in Guam amyotrophic lateral sclerosis/parkinsonism-dementia complex contain species of A beta similar to those found in the amyloid plaques of Alzheimer's disease and pathological aging.
Acta neuropathologica 1998;95(2):117-22.
1998: Andrew P Lieberman; John Q Trojanowski; Virginia M-Y Lee; Brian J Balin; XS Ding; Joel Greenberg; D Morrison; Martin Reivich; Murray Grossman
Cognitive, neuroimaging, and pathological studies in a patient with Pick's disease.
Annals of neurology 1998;43(2):259-65.
1998: John Q Trojanowski; Virginia M-Y Lee
Aggregation of neurofilament and alpha-synuclein proteins in Lewy bodies: implications for the pathogenesis of Parkinson disease and Lewy body dementia.
Archives of neurology 1998;55(2):151-2.
1997: Mark S Forman; David G Cook; Susan Leight; Robert W Doms; Virginia M-Y Lee
Differential effects of the swedish mutant amyloid precursor protein on beta-amyloid accumulation and secretion in neurons and nonneuronal cells.
The Journal of biological chemistry 1997;272(51):32247-53.
1997: Bin Zhang; P Tu; Farhad Abtahian; John Q Trojanowski; Virginia M-Y Lee
Neurofilaments and orthograde transport are reduced in ventral root axons of transgenic mice that express human SOD1 with a G93A mutation.
The Journal of cell biology 1997;139(5):1307-15.
1997: M Hong; D C Chen; Peter S Klein; Virginia M-Y Lee
Lithium reduces tau phosphorylation by inhibition of glycogen synthase kinase-3.
The Journal of biological chemistry 1997;272(40):25326-32.
1997: James E Galvin; Virginia M-Y Lee; M Baba; D M A Mann; dennis dickson; H Yamaguchi; M Luise Schmidt; Takeshi Iwatsubo; John Q Trojanowski
Monoclonal antibodies to purified cortical Lewy bodies recognize the mid-size neurofilament subunit.
Annals of neurology 1997;42(4):595-603.
1997: Hiroyuki Arai; M Terajima; M Miura; Susumu Higuchi; T Muramatsu; Sachio Matsushita; N Machida; T Nakagawa; Virginia M-Y Lee; John Q Trojanowski; Hidetada Sasaki
Effect of genetic risk factors and disease progression on the cerebrospinal fluid tau levels in Alzheimer's disease.
Journal of the American Geriatrics Society 1997;45(10):1228-31.
1997: Thomas T Chou; John Q Trojanowski; Virginia M-Y Lee
Neurotrophin signal transduction in medulloblastoma.
Journal of neuroscience research 1997;49(5):522-7.
1997: David G Cook; Mark S Forman; J C Sung; Susan Leight; D L Kolson; Takeshi Iwatsubo; Virginia M-Y Lee; Robert W Doms
Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells.
Nature medicine 1997;3(9):1021-3.
1997: Maria Grazia Spillantini; M L Schmidt; Virginia M-Y Lee; John Q Trojanowski; R Jakes; Michel Goedert
Alpha-synuclein in Lewy bodies.
Nature 1997;388(6645):839-40.
1997: A S Chyung; Barry D Greenberg; David G Cook; Robert W Doms; Virginia M-Y Lee
Novel beta-secretase cleavage of beta-amyloid precursor protein in the endoplasmic reticulum/intermediate compartment of NT2N cells.
The Journal of cell biology 1997;138(3):671-80.
1997: M Hong; Virginia M-Y Lee
Insulin and insulin-like growth factor-1 regulate tau phosphorylation in cultured human neurons.
The Journal of biological chemistry 1997;272(31):19547-53.
1997: S E Merrick; John Q Trojanowski; Virginia M-Y Lee
Selective destruction of stable microtubules and axons by inhibitors of protein serine/threonine phosphatases in cultured human neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(15):5726-37.
1997: Hiroyuki Arai; Y Morikawa; M Higuchi; Toshifumi Matsui; C M Clark; M Miura; N Machida; Virginia M-Y Lee; John Q Trojanowski; Hidetada Sasaki
Cerebrospinal fluid tau levels in neurodegenerative diseases with distinct tau-related pathology.
Biochemical and biophysical research communications 1997;236(2):262-4.
1997: K M Fung; J Peringa; S Venkatachalam; Virginia M-Y Lee; John Q Trojanowski
Coordinate reduction in cell proliferation and cell death in mouse olfactory epithelium from birth to maturity.
Brain research 1997;761(2):347-51.
1997: John Q Trojanowski; Christopher M Clark; M Luise Schmidt; Steven E Arnold; Virginia M-Y Lee
Strategies for improving the postmortem neuropathological diagnosis of Alzheimer's disease.
Neurobiology of aging 1997;18(4 Suppl):S75-9.
1997: M Luise Schmidt; Virginia M-Y Lee; M Forman; T S Chiu; John Q Trojanowski
Monoclonal antibodies to a 100-kd protein reveal abundant A beta-negative plaques throughout gray matter of Alzheimer's disease brains.
The American journal of pathology 1997;151(1):69-80.
1997: F Lai; CX Chen; Virginia M-Y Lee; Kazuko Nishikura
Dramatic increase of the RNA editing for glutamate receptor subunits during terminal differentiation of clonal human neurons.
Journal of neurochemistry 1997;69(1):43-52.
1997: Ralf Hoffmann; Virginia M-Y Lee; S Leight; I Varga; Laszlo Otvos
Unique Alzheimer's disease paired helical filament specific epitopes involve double phosphorylation at specific sites.
Biochemistry 1997;36(26):8114-24.
1997: Michelle C LaPlaca; Virginia M-Y Lee; LE Thibault
An in vitro model of traumatic neuronal injury: loading rate-dependent changes in acute cytosolic calcium and lactate dehydrogenase release.
Journal of neurotrauma 1997;14(6):355-68.
1997: CM Hedgepeth; L J Conrad; J Zhang; Hui-Chuan Huang; Virginia M-Y Lee; Peter S Klein
Activation of the Wnt signaling pathway: a molecular mechanism for lithium action.
Developmental biology 1997;185(1):82-91.
1997: Lucy B Rorke; John Q Trojanowski; Virginia M-Y Lee; R A Zimmerman; Leslie N Sutton; Jaclyn A Biegel; Joel Goldwein; R J Packer
Primitive neuroectodermal tumors of the central nervous system.
Brain pathology (Zurich, Switzerland) 1997;7(2):765-84.
1997: Pang-hsien Tu; M E Gurney; J P Julien; Virginia M-Y Lee; John Q Trojanowski
Oxidative stress, mutant SOD1, and neurofilament pathology in transgenic mouse models of human motor neuron disease.
Laboratory investigation; a journal of technical methods and pathology 1997;76(4):441-56.
1997: John Q Trojanowski; S R Kleppner; R S Hartley; M Miyazono; Nigel W Fraser; Santosh kesari; Virginia M-Y Lee
Transfectable and transplantable postmitotic human neurons: a potential "platform" for gene therapy of nervous system diseases.
Experimental neurology 1997;144(1):92-7.
1997: Stephen D. Ginsberg; Peter B Crino; Virginia M-Y Lee; james eberwine; John Q Trojanowski
Sequestration of RNA in Alzheimer's disease neurofibrillary tangles and senile plaques.
Annals of neurology 1997;41(2):200-9.
1997: Pang-hsien Tu; K A Robinson; F de Snoo; Joël Eyer; A Peterson; Virginia M-Y Lee; John Q Trojanowski
Selective degeneration fo Purkinje cells with Lewy body-like inclusions in aged NFHLACZ transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(3):1064-74.
1997: Y Muragaki; Thomas T Chou; D R Kaplan; John Q Trojanowski; Virginia M-Y Lee
Nerve growth factor induces apoptosis in human medulloblastoma cell lines that express TrkA receptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(2):530-42.
1996: M Miyazono; P C Nowell; J L Finan; Virginia M-Y Lee; John Q Trojanowski
Long-term integration and neuronal differentiation of human embryonal carcinoma cells (NTera-2) transplanted into the caudoputamen of nude mice.
The Journal of comparative neurology 1996;376(4):603-13.
1996: TM Lasner; Santosh kesari; S M Brown; Virginia M-Y Lee; Nigel W Fraser; John Q Trojanowski
Therapy of a murine model of pediatric brain tumors using a herpes simplex virus type-1 ICP34.5 mutant and demonstration of viral replication within the CNS.
Journal of neuropathology and experimental neurology 1996;55(12):1259-69.
1996: Takeshi Iwatsubo; Takaomi C Saido; D M A Mann; Virginia M-Y Lee; John Q Trojanowski
Full-length amyloid-beta (1-42(43)) and amino-terminally modified and truncated amyloid-beta 42(43) deposit in diffuse plaques.
The American journal of pathology 1996;149(6):1823-30.
1996: D G Cook; Raymond Scott Turner; Dennis L Kolson; Virginia M-Y Lee; Robert W Doms
Vaccinia virus serves as an efficient vector for expressing heterologous proteins in human NTera 2 neurons.
The Journal of comparative neurology 1996;374(4):481-92.
1996: M Mawal-Dewan; M Luise Schmidt; Brian J Balin; Daniel P Perl; Virginia M-Y Lee; John Q Trojanowski
Identification of phosphorylation sites in PHF-TAU from patients with Guam amyotrophic lateral sclerosis/parkinsonism-dementia complex.
Journal of neuropathology and experimental neurology 1996;55(10):1051-9.
1996: Santosh kesari; Virginia M-Y Lee; S M Brown; John Q Trojanowski; Nigel W Fraser
Selective vulnerability of mouse CNS neurons to latent infection with a neuroattenuated herpes simplex virus-1.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(18):5644-53.
1996: Bradford Poulos; M Perazzolo; Virginia M-Y Lee; R Rudelli; Henryk M Wisniewski; D Soifer
Oral aluminum administration during pregnancy and lactation produces gastric and renal lesions in rat mothers and delay in CNS development of their pups.
Molecular and chemical neuropathology / sponsored by the International Society for Neurochemistry and the World Federation of Neurology and research groups on neurochemistry and cerebrospinal fluid 1996;29(1):15-26.
1996: D G Cook; J C Sung; todd golde; K M Felsenstein; Boguslaw S Wojczyk; Rudolph E Tanzi; John Q Trojanowski; Virginia M-Y Lee; Robert W Doms
Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(17):9223-8.
1996: Mariko Tokito; D S Howland; Virginia M-Y Lee; Erika L F Holzbaur
Functionally distinct isoforms of dynactin are expressed in human neurons.
Molecular biology of the cell 1996;7(8):1167-80.
1996: Takeshi Iwatsubo; H Yamaguchi; Masahiro Fujimuro; Hideyoshi Yokosawa; Yasuo Ihara; John Q Trojanowski; Virginia M-Y Lee
Lewy bodies: purification from diffuse Lewy body disease brains.
Annals of the New York Academy of Sciences 1996;786():195-205.
1996: M Luise Schmidt; R Huang; J A Martin; J Henley; M Mawal-Dewan; Howard I Hurtig; Virginia M-Y Lee; John Q Trojanowski
Neurofibrillary tangles in progressive supranuclear palsy contain the same tau epitopes identified in Alzheimer's disease PHFtau.
Journal of neuropathology and experimental neurology 1996;55(5):534-9.
1996: Takeshi Iwatsubo; H Yamaguchi; Masahiro Fujimuro; Hideyoshi Yokosawa; Yasuo Ihara; John Q Trojanowski; Virginia M-Y Lee
Purification and characterization of Lewy bodies from the brains of patients with diffuse Lewy body disease.
The American journal of pathology 1996;148(5):1517-29.
1996: Raymond Scott Turner; N Suzuki; A S Chyung; Steven G Younkin; Virginia M-Y Lee
Amyloids beta40 and beta42 are generated intracellularly in cultured human neurons and their secretion increases with maturation.
The Journal of biological chemistry 1996;271(15):8966-70.
1996: M Hasegawa; Ross Jakes; R Anthony Crowther; Virginia M-Y Lee; Yasuo Ihara; Michel Goedert
Characterization of mAb AP422, a novel phosphorylation-dependent monoclonal antibody against tau protein.
FEBS letters 1996;384(1):25-30.
1996: Pang-hsien Tu; P Raju; K A Robinson; M E Gurney; John Q Trojanowski; Virginia M-Y Lee
Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(7):3155-60.
1996: G I Szendrei; K V Prammer; M Vasko; Virginia M-Y Lee; Laszlo Otvos
The effects of aspartic acid-bond isomerization on in vitro properties of the amyloid beta-peptide as modeled with N-terminal decapeptide fragments.
International journal of peptide and protein research 1996;47(4):289-96.
1996: Anna Janss; Anthony T Yachnis; Jeffrey H Silber; John Q Trojanowski; Virginia M-Y Lee; Leslie N Sutton; G Perilongo; Lucy B Rorke; Peter C Phillips
Glial differentiation predicts poor clinical outcome in primitive neuroectodermal brain tumors.
Annals of neurology 1996;39(4):481-9.
1996: S E Merrick; D C Demoise; Virginia M-Y Lee
Site-specific dephosphorylation of tau protein at Ser202/Thr205 in response to microtubule depolymerization in cultured human neurons involves protein phosphatase 2A.
The Journal of biological chemistry 1996;271(10):5589-94.
1996: K Washiyama; Y Muragaki; Lucy B Rorke; Virginia M-Y Lee; Stuart C Feinstein; Monte J Radeke; D Blumberg; D R Kaplan; John Q Trojanowski
Neurotrophin and neurotrophin receptor proteins in medulloblastomas and other primitive neuroectodermal tumors of the pediatric central nervous system.
The American journal of pathology 1996;148(3):929-40.
1996: Jeanne F Loring; C Paszty; A Rose; T K McIntosh; H Murai; JE Pierce; S R Schramm; K Wymore; Virginia M-Y Lee; John Q Trojanowski; K R Peterson
Rational design of an animal model for Alzheimer's disease: introduction of multiple human genomic transgenes to reproduce AD pathology in a rodent.
Neurobiology of aging 1996;17(2):173-82.
1996: Virginia M-Y Lee
Regulation of tau phosphorylation in Alzheimer's disease.
Annals of the New York Academy of Sciences 1996;777():107-13.
1996: M Luise Schmidt; J A Martin; Virginia M-Y Lee; John Q Trojanowski
Convergence of Lewy bodies and neurofibrillary tangles in amygdala neurons of Alzheimer's disease and Lewy body disorders.
Acta neuropathologica 1996;91(5):475-81.
1995: John Q Trojanowski; Virginia M-Y Lee
Phosphorylation of paired helical filament tau in Alzheimer's disease neurofibrillary lesions: focusing on phosphatases.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1995;9(15):1570-6.
1995: A Rink; K M Fung; John Q Trojanowski; Virginia M-Y Lee; E Neugebauer; T K McIntosh
Evidence of apoptotic cell death after experimental traumatic brain injury in the rat.
The American journal of pathology 1995;147(6):1575-83.
1995: Santosh kesari; BP Randazzo; Tibor Valyi-Nagy; Q S Huang; S M Brown; A R MacLean; Virginia M-Y Lee; John Q Trojanowski; Nigel W Fraser
Therapy of experimental human brain tumors using a neuroattenuated herpes simplex virus mutant.
Laboratory investigation; a journal of technical methods and pathology 1995;73(5):636-48.
1995: Virginia M-Y Lee
Disruption of the cytoskeleton in Alzheimer's disease.
Current opinion in neurobiology 1995;5(5):663-8.
1995: R W Shin; Virginia M-Y Lee; John Q Trojanowski
Neurofibrillary pathology and aluminum in Alzheimer's disease.
Histology and histopathology 1995;10(4):969-78.
1995: Hiroyuki Arai; M Terajima; M Miura; Susumu Higuchi; T Muramatsu; N Machida; H Seiki; S Takase; C M Clark; Virginia M-Y Lee
Tau in cerebrospinal fluid: a potential diagnostic marker in Alzheimer's disease.
Annals of neurology 1995;38(4):649-52.
1995: B R Sperber; Susan Leight; Michel Goedert; Virginia M-Y Lee
Glycogen synthase kinase-3 beta phosphorylates tau protein at multiple sites in intact cells.
Neuroscience letters 1995;197(2):149-53.
1995: Peter B Crino; J A Martin; William Hill; Barry D Greenberg; Virginia M-Y Lee; John Q Trojanowski
Beta-Amyloid peptide and amyloid precursor proteins in olfactory mucosa of patients with Alzheimer's disease, Parkinson's disease, and Down syndrome.
The Annals of otology, rhinology, and laryngology 1995;104(8):655-61.
1995: M Luise Schmidt; Katherine A Robinson; Virginia M-Y Lee; John Q Trojanowski
Chemical and immunological heterogeneity of fibrillar amyloid in plaques of Alzheimer's disease and Down's syndrome brains revealed by confocal microscopy.
The American journal of pathology 1995;147(2):503-15.
1995: M Miyazono; Virginia M-Y Lee; John Q Trojanowski
Proliferation, cell death, and neuronal differentiation in transplanted human embryonal carcinoma (NTera2) cells depend on the graft site in nude and severe combined immunodeficient mice.
Laboratory investigation; a journal of technical methods and pathology 1995;73(2):273-83.
1995: S R Kleppner; K A Robinson; John Q Trojanowski; Virginia M-Y Lee
Transplanted human neurons derived from a teratocarcinoma cell line (NTera-2) mature, integrate, and survive for over 1 year in the nude mouse brain.
The Journal of comparative neurology 1995;357(4):618-32.
1995: Y Muragaki; N Timothy; Susan Leight; Barbara L Hempstead; M V Chao; John Q Trojanowski; Virginia M-Y Lee
Expression of trk receptors in the developing and adult human central and peripheral nervous system.
The Journal of comparative neurology 1995;356(3):387-97.
1995: Pang-hsien Tu; Gregory A Elder; Robert A Lazzarini; D Nelson; John Q Trojanowski; Virginia M-Y Lee
Overexpression of the human NFM subunit in transgenic mice modifies the level of endogenous NFL and the phosphorylation state of NFH subunits.
The Journal of cell biology 1995;129(6):1629-40.
1995: K M Fung; Virginia M-Y Lee; John Q Trojanowski
Dynamics of cell proliferation and cell death during the emergence of primitive neuroectodermal tumors of the immature central nervous system in transgenic mice.
The American journal of pathology 1995;146(6):1376-87.
1995: John Q Trojanowski; R W Shin; M Luise Schmidt; Virginia M-Y Lee
Relationship between plaques, tangles, and dystrophic processes in Alzheimer's disease.
Neurobiology of aging 1995;16(3):335-40; discussion 341-5.
1995: S E Merrick; S J Pleasure; D I Lurie; Donald Pijak; Michael E Selzer; Virginia M-Y Lee
Glial cells of the lamprey nervous system contain keratin-like proteins.
The Journal of comparative neurology 1995;355(2):199-210.
1995: Bryan A Wolf; A M Wertkin; Y C Jolly; R P Yasuda; Barry B Wolfe; R J Konrad; D Manning; S Ravi; JR Williamson; Virginia M-Y Lee
Muscarinic regulation of Alzheimer's disease amyloid precursor protein secretion and amyloid beta-protein production in human neuronal NT2N cells.
The Journal of biological chemistry 1995;270(9):4916-22.
1995: G F Hall; Virginia M-Y Lee
Neurofilament sidearm proteolysis is a prominent early effect of axotomy in lamprey giant central neurons.
The Journal of comparative neurology 1995;353(1):38-49.
1995: J R Mantione; S R Kleppner; M Miyazono; A M Wertkin; Virginia M-Y Lee; John Q Trojanowski
Human neurons that constitutively secrete A beta do not induce Alzheimer's disease pathology following transplantation and long-term survival in the rodent brain.
Brain research 1995;671(2):333-7.
1995: Iwona A Auer; M Luise Schmidt; Virginia M-Y Lee; B Curry; Kinuko Suzuki; R W Shin; Peter G Pentchev; ED Carstea; John Q Trojanowski
Paired helical filament tau (PHFtau) in Niemann-Pick type C disease is similar to PHFtau in Alzheimer's disease.
Acta neuropathologica 1995;90(6):547-51.
1995: M G Martinoli; John Q Trojanowski; M Luise Schmidt; Steven E Arnold; T M Fujiwara; Virginia M-Y Lee; Howard I Hurtig; Jean-Pierre Julien; C Clark
Association of apolipoprotein epsilon 4 allele and neuropathologic findings in patients with dementia.
Acta neuropathologica 1995;90(3):239-43.
1995: B Q Kreider; J B Grinspan; M B Waterstone; G T Bramblett; B Ances; M Williams; J Stern; Virginia M-Y Lee; David Pleasure
Partial purification of a novel mitogen for oligodendroglia.
Journal of neuroscience research 1995;40(1):44-53.
1994: Virginia M-Y Lee; Sarah K Pixley
Age and differentiation-related differences in neuron-specific tubulin immunostaining of olfactory sensory neurons.
Brain research. Developmental brain research 1994;83(2):209-15.
1994: John Q Trojanowski; Virginia M-Y Lee
Phosphorylation of neuronal cytoskeletal proteins in Alzheimer's disease and Lewy body dementias.
Annals of the New York Academy of Sciences 1994;747():92-109.
1994: Laszlo Otvos; L Feiner; E Lang; G I Szendrei; Michel Goedert; Virginia M-Y Lee
Monoclonal antibody PHF-1 recognizes tau protein phosphorylated at serine residues 396 and 404.
Journal of neuroscience research 1994;39(6):669-73.
1994: M Mawal-Dewan; J Henley; A Van de Voorde; John Q Trojanowski; Virginia M-Y Lee
The phosphorylation state of tau in the developing rat brain is regulated by phosphoprotein phosphatases.
The Journal of biological chemistry 1994;269(49):30981-7.
1994: T D Garver; K A Harris; R A Lehman; Virginia M-Y Lee; John Q Trojanowski; Melvin Billingsley
Tau phosphorylation in human, primate, and rat brain: evidence that a pool of tau is highly phosphorylated in vivo and is rapidly dephosphorylated in vitro.
Journal of neurochemistry 1994;63(6):2279-87.
1994: M Luise Schmidt; A G DiDario; Laszlo Otvos; N Hoshi; J A Kant; Virginia M-Y Lee; John Q Trojanowski
Plaque-associated neuronal proteins: a recurrent motif in neuritic amyloid deposits throughout diverse cortical areas of the Alzheimer's disease brain.
Experimental neurology 1994;130(2):311-22.
1994: J S Cole; Albee Messing; John Q Trojanowski; Virginia M-Y Lee
Modulation of axon diameter and neurofilaments by hypomyelinating Schwann cells in transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1994;14(11 Pt 2):6956-66.
1994: R W Shin; Virginia M-Y Lee; John Q Trojanowski
Aluminum modifies the properties of Alzheimer's disease PHF tau proteins in vivo and in vitro.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1994;14(11 Pt 2):7221-33.
1994: E S Matsuo; R W Shin; Melvin Billingsley; A Van deVoorde; M O'Connor; John Q Trojanowski; Virginia M-Y Lee
Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau.
Neuron 1994;13(4):989-1002.
1994: M Luise Schmidt; A G DiDario; Virginia M-Y Lee; John Q Trojanowski
An extensive network of PHF tau-rich dystrophic neurites permeates neocortex and nearly all neuritic and diffuse amyloid plaques in Alzheimer disease.
FEBS letters 1994;344(1):69-73.
1994: Hiroyuki Arai; S Higuchi; S Matsushita; T Yuzuriha; John Q Trojanowski; Virginia M-Y Lee
Expression of beta-amyloid precursor protein in the developing human spinal cord.
Brain research 1994;642(1-2):132-6.
1994: Melvin Billingsley; C Ellis; R L Kincaid; J Martin; M L Schmidt; Virginia M-Y Lee; John Q Trojanowski
Calcineurin immunoreactivity in Alzheimer's disease.
Experimental neurology 1994;126(2):178-84.
1994: E Lang; G I Szendrei; Virginia M-Y Lee; Laszlo Otvos
Spectroscopic evidence that monoclonal antibodies recognize the dominant conformation of medium-sized synthetic peptides.
Journal of immunological methods 1994;170(1):103-15.
1994: John Q Trojanowski; Virginia M-Y Lee
Paired helical filament tau in Alzheimer's disease. The kinase connection.
The American journal of pathology 1994;144(3):449-53.
1994: U Bickel; Virginia M-Y Lee; John Q Trojanowski; William M Pardridge
Development and in vitro characterization of a cationized monoclonal antibody against beta A4 protein: a potential probe for Alzheimer's disease.
Bioconjugate chemistry 1994;5(2):119-25.
1994: John Q Trojanowski; K M Fung; Lucy B Rorke; T Tohyama; Anthony T Yachnis; Virginia M-Y Lee
In vivo and in vitro models of medulloblastomas and other primitive neuroectodermal brain tumors of childhood.
Molecular and chemical neuropathology / sponsored by the International Society for Neurochemistry and the World Federation of Neurology and research groups on neurochemistry and cerebrospinal fluid 1994;21(2-3):219-39.
1994: dennis dickson; M L Schmidt; Virginia M-Y Lee; Meng-Liang Zhao; Shu-Hui C. Yen; John Q Trojanowski
Immunoreactivity profile of hippocampal CA2/3 neurites in diffuse Lewy body disease.
Acta neuropathologica 1994;87(3):269-76.
1994: D G Cook; Virginia M-Y Lee; Robert W Doms
Expression of foreign proteins in a human neuronal system.
Methods in cell biology 1994;43 Pt A():289-303.
1994: Virginia M-Y Lee; R Daughenbaugh; John Q Trojanowski
Microtubule stabilizing drugs for the treatment of Alzheimer's disease.
Neurobiology of aging 1994;15 Suppl 2():S87-9.
1994: K M Fung; Dona M Chikaraishi; C Suri; F Theuring; Albee Messing; Daniel M Albert; Virginia M-Y Lee; John Q Trojanowski
Molecular phenotype of simian virus 40 large T antigen-induced primitive neuroectodermal tumors in four different lines of transgenic mice.
Laboratory investigation; a journal of technical methods and pathology 1994;70(1):114-24.
1993: M M Lo; A W Fieles; T E Norris; P G Dargis; C B Caputo; C W Scott; Virginia M-Y Lee; Michel Goedert
Human tau isoforms confer distinct morphological and functional properties to stably transfected fibroblasts.
Brain research. Molecular brain research 1993;20(3):209-20.
1993: A M Wertkin; Raymond Scott Turner; S J Pleasure; todd golde; Steven G Younkin; John Q Trojanowski; Virginia M-Y Lee
Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(20):9513-7.
1993: S J Pleasure; Virginia M-Y Lee
NTera 2 cells: a human cell line which displays characteristics expected of a human committed neuronal progenitor cell.
Journal of neuroscience research 1993;35(6):585-602.
1993: Anthony T Yachnis; Lucy B Rorke; Virginia M-Y Lee; John Q Trojanowski
Expression of neuronal and glial polypeptides during histogenesis of the human cerebellar cortex including observations on the dentate nucleus.
The Journal of comparative neurology 1993;334(3):356-69.
1993: John Q Trojanowski; M Mawal-Dewan; M Luise Schmidt; J Martin; Virginia M-Y Lee
Localization of the mitogen activated protein kinase ERK2 in Alzheimer's disease neurofibrillary tangles and senile plaque neurites.
Brain research 1993;618(2):333-7.
1993: John Q Trojanowski; J R Mantione; J H Lee; D P Seid; T You; L J Inge; Virginia M-Y Lee
Neurons derived from a human teratocarcinoma cell line establish molecular and structural polarity following transplantation into the rodent brain.
Experimental neurology 1993;122(2):283-94.
1993: R W Shin; G T Bramblett; Virginia M-Y Lee; John Q Trojanowski
Alzheimer disease A68 proteins injected into rat brain induce codeposits of beta-amyloid, ubiquitin, and alpha 1-antichymotrypsin.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(14):6825-8.
1993: Catherine Lubetzki; C Demerens; P Anglade; H Villarroya; A Frankfurter; Virginia M-Y Lee; Bernard Zalc
Even in culture, oligodendrocytes myelinate solely axons.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(14):6820-4.
1993: T Tohyama; Virginia M-Y Lee; Lucy B Rorke; M Marvin; Ronald D G McKay; John Q Trojanowski
Monoclonal antibodies to a rat nestin fusion protein recognize a 220-kDa polypeptide in subsets of fetal and adult human central nervous system neurons and in primitive neuroectodermal tumor cells.
The American journal of pathology 1993;143(1):258-68.
1993: Michel Goedert; Ross Jakes; R Anthony Crowther; J Six; Ursula Lübke; M Vandermeeren; Patrick Cras; John Q Trojanowski; Virginia M-Y Lee
The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(11):5066-70.
1993: G T Bramblett; Michel Goedert; R Jakes; S E Merrick; John Q Trojanowski; Virginia M-Y Lee
Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding.
Neuron 1993;10(6):1089-99.
1993: J H Lee; Michel Goedert; William Hill; Virginia M-Y Lee; John Q Trojanowski
Tau proteins are abnormally expressed in olfactory epithelium of Alzheimer patients and developmentally regulated in human fetal spinal cord.
Experimental neurology 1993;121(1):93-105.
1993: D P Younkin; Cha-Min Tang; M Hardy; U R Reddy; Q Y Shi; S J Pleasure; Virginia M-Y Lee; David Pleasure
Inducible expression of neuronal glutamate receptor channels in the NT2 human cell line.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(6):2174-8.
1993: T Tlhyama; Virginia M-Y Lee; John Q Trojanowski
Co-expression of low molecular weight neurofilament protein and glial fibrillary acidic protein in established human glioma cell lines.
The American journal of pathology 1993;142(3):883-92.
1993: G I Szendrei; Virginia M-Y Lee; Laszlo Otvos
Recognition of the minimal epitope of monoclonal antibody Tau-1 depends upon the presence of a phosphate group but not its location.
Journal of neuroscience research 1993;34(2):243-9.
1993: Laszlo Otvos; G I Szendrei; Virginia M-Y Lee; Henry H Mantsch
Human and rodent Alzheimer beta-amyloid peptides acquire distinct conformations in membrane-mimicking solvents.
European journal of biochemistry / FEBS 1993;211(1-2):249-57.
1993: John Q Trojanowski; M Luise Schmidt; R W Shin; G T Bramblett; D Rao; Virginia M-Y Lee
Altered tau and neurofilament proteins in neuro-degenerative diseases: diagnostic implications for Alzheimer's disease and Lewy body dementias.
Brain pathology (Zurich, Switzerland) 1993;3(1):45-54.
1992: Virginia M-Y Lee; John Q Trojanowski
The disordered neuronal cytoskeleton in Alzheimer's disease.
Current opinion in neurobiology 1992;2(5):653-6.
1992: John Q Trojanowski; T Tohyama; Virginia M-Y Lee
Medulloblastomas and related primitive neuroectodermal brain tumors of childhood recapitulate molecular milestones in the maturation of neuroblasts.
Molecular and chemical neuropathology / sponsored by the International Society for Neurochemistry and the World Federation of Neurology and research groups on neurochemistry and cerebrospinal fluid 1992;17(2):121-35.
1992: E Lang; G I Szendrei; Virginia M-Y Lee; Laszlo Otvos
Immunological and conformation characterization of a phosphorylated immunodominant epitope on the paired helical filaments found in Alzheimer's disease.
Biochemical and biophysical research communications 1992;187(2):783-90.
1992: K M Fung; Albee Messing; Virginia M-Y Lee; John Q Trojanowski
A novel modification of the avidin-biotin complex method for immunohistochemical studies of transgenic mice with murine monoclonal antibodies.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1992;40(9):1319-28.
1992: Virginia M-Y Lee; Gregory A Elder; L C Chen; Z Liang; SE Snyder; Victor L Friedrich; Robert A Lazzarini
Expression of human mid-sized neurofilament subunit in transgenic mice.
Brain research. Molecular brain research 1992;15(1-2):76-84.
1992: Hiroyuki Arai; Virginia M-Y Lee; William Hill; Barry D Greenberg; John Q Trojanowski
Lewy bodies contain beta-amyloid precursor proteins of Alzheimer's disease.
Brain research 1992;585(1-2):386-90.
1992: Heii Arai; M Luise Schmidt; Virginia M-Y Lee; Howard I Hurtig; Barry D Greenberg; Charles H Adler; John Q Trojanowski
Epitope analysis of senile plaque components in the hippocampus of patients with Parkinson's disease.
Neurology 1992;42(7):1315-22.
1992: S J Pleasure; C Page; Virginia M-Y Lee
Pure, postmitotic, polarized human neurons derived from NTera 2 cells provide a system for expressing exogenous proteins in terminally differentiated neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1992;12(5):1802-15.
1992: T Tohyama; Virginia M-Y Lee; Lucy B Rorke; M Marvin; Ronald D G McKay; John Q Trojanowski
Nestin expression in embryonic human neuroepithelium and in human neuroepithelial tumor cells.
Laboratory investigation; a journal of technical methods and pathology 1992;66(3):303-13.
1992: S M de Waegh; Virginia M-Y Lee; Scott T Brady
Local modulation of neurofilament phosphorylation, axonal caliber, and slow axonal transport by myelinating Schwann cells.
Cell 1992;68(3):451-63.
1992: G T Bramblett; John Q Trojanowski; Virginia M-Y Lee
Regions with abundant neurofibrillary pathology in human brain exhibit a selective reduction in levels of binding-competent tau and accumulation of abnormal tau-isoforms (A68 proteins).
Laboratory investigation; a journal of technical methods and pathology 1992;66(2):212-22.
1992: E Lang; G I Szendrei; I Elekes; Virginia M-Y Lee; Laszlo Otvos
Reversible beta-pleated sheet formation of a phosphorylated synthetic tau peptide.
Biochemical and biophysical research communications 1992;182(1):63-9.
1992: I Laczkó-Hollósi; Miklós Hollósi; Virginia M-Y Lee; Henry Mantsch
Conformational change of a synthetic amyloid analogue des[Ala21,30]A42 upon binding to octyl glucoside micelles.
European biophysics journal : EBJ 1992;21(5):345-8.
1991: Steven E Arnold; Virginia M-Y Lee; R E Gur; John Q Trojanowski
Abnormal expression of two microtubule-associated proteins (MAP2 and MAP5) in specific subfields of the hippocampal formation in schizophrenia.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(23):10850-4.
1991: Heii Arai; Virginia M-Y Lee; M L Messinger; Barry D Greenberg; D E Lowery; John Q Trojanowski
Expression patterns of beta-amyloid precursor protein (beta-APP) in neural and nonneural human tissues from Alzheimer's disease and control subjects.
Annals of neurology 1991;30(5):686-93.
1991: H J Lee; G J Elliot; D N Hammond; Virginia M-Y Lee; B H Wainer
Constitutive expression of the mature array of neurofilament proteins by a CNS neuronal cell line.
Brain research 1991;558(2):197-208.
1991: E A Clark; Virginia M-Y Lee
The differential role of protein kinase C isozymes in the rapid induction of neurofilament phosphorylation by nerve growth factor and phorbol esters in PC12 cells.
Journal of neurochemistry 1991;57(3):802-10.
1991: E A Clark; Virginia M-Y Lee
Dynamics of mammalian high-molecular-weight neurofilament subunit phosphorylation in cultured rat sympathetic neurons.
Journal of neuroscience research 1991;30(1):116-23.
1991: D G Standaert; Virginia M-Y Lee; Barry D Greenberg; D E Lowery; John Q Trojanowski
Molecular features of hypothalamic plaques in Alzheimer's disease.
The American journal of pathology 1991;139(3):681-91.
1991: Brian J Balin; Virginia M-Y Lee
Individual neurofilament subunits reassembled in vitro exhibit unique biochemical, morphological and immunological properties.
Brain research 1991;556(2):196-208.
1991: Brian J Balin; E A Clark; John Q Trojanowski; Virginia M-Y Lee
Neurofilament reassembly in vitro: biochemical, morphological and immuno-electron microscopic studies employing monoclonal antibodies to defined epitopes.
Brain research 1991;556(2):181-95.
1991: T Tohyama; Virginia M-Y Lee; Lucy B Rorke; John Q Trojanowski
Molecular milestones that signal axonal maturation and the commitment of human spinal cord precursor cells to the neuronal or glial phenotype in development.
The Journal of comparative neurology 1991;310(3):285-99.
1991: John Q Trojanowski; P D Newman; William Hill; Virginia M-Y Lee
Human olfactory epithelium in normal aging, Alzheimer's disease, and other neurodegenerative disorders.
The Journal of comparative neurology 1991;310(3):365-76.
1991: N J Meropol; B L Kreider; Virginia M-Y Lee; K Kaushansky; Michael B Prystowsky
A neutralizing monoclonal antibody binds to an epitope near the amino terminus of murine granulocyte-macrophage colony-stimulating factor.
Hybridoma 1991;10(4):433-47.
1991: William Hill; Virginia M-Y Lee; Howard I Hurtig; J M Murray; John Q Trojanowski
Epitopes located in spatially separate domains of each neurofilament subunit are present in Parkinson's disease Lewy bodies.
The Journal of comparative neurology 1991;309(1):150-60.
1991: M Luise Schmidt; J Murray; Virginia M-Y Lee; William Hill; A Wertkin; John Q Trojanowski
Epitope map of neurofilament protein domains in cortical and peripheral nervous system Lewy bodies.
The American journal of pathology 1991;139(1):53-65.
1991: D L Baker; W M Molenaar; John Q Trojanowski; A E Evans; Alonzo H Ross; Lucy B Rorke; R J Packer; Virginia M-Y Lee; David Pleasure
Nerve growth factor receptor expression in peripheral and central neuroectodermal tumors, other pediatric brain tumors, and during development of the adrenal gland.
The American journal of pathology 1991;139(1):115-22.
1991: B G Szaro; Philip Grant; Virginia M-Y Lee; Harold Gainer
Inhibition of axonal development after injection of neurofilament antibodies into a Xenopus laevis embryo.
The Journal of comparative neurology 1991;308(4):576-85.
1991: G F Hall; Virginia M-Y Lee; Kenneth S Kosik
Microtubule destabilization and neurofilament phosphorylation precede dendritic sprouting after close axotomy of lamprey central neurons.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(11):5016-20.
1991: L Mulligan; Brian J Balin; Virginia M-Y Lee; Wallace Ip
Antibody labeling of bovine neurofilaments: implications on the structure of neurofilament sidearms.
Journal of structural biology 1991;106(2):145-60.
1991: M Luise Schmidt; Virginia M-Y Lee; John Q Trojanowski
Comparative epitope analysis of neuronal cytoskeletal proteins in Alzheimer's disease senile plaque neurites and neuropil threads.
Laboratory investigation; a journal of technical methods and pathology 1991;64(3):352-7.
1991: Virginia M-Y Lee; Brian J Balin; Laszlo Otvos; John Q Trojanowski
A68: a major subunit of paired helical filaments and derivatized forms of normal Tau.
Science (New York, N.Y.) 1991;251(4994):675-8.
1991: John Q Trojanowski; W M Molenaar; D L Baker; David Pleasure; Virginia M-Y Lee
Neural and neuroendocrine phenotype of neuroblastomas, ganglioneuroblastomas, ganglioneuromas and mature versus embryonic human adrenal medullary cells.
Progress in clinical and biological research 1991;366():335-41.
1991: E A Clark; K L Leach; John Q Trojanowski; Virginia M-Y Lee
Characterization and differential distribution of the three major human protein kinase C isozymes (PKC alpha, PKC beta, and PKC gamma) of the central nervous system in normal and Alzheimer's disease brains.
Laboratory investigation; a journal of technical methods and pathology 1991;64(1):35-44.
1991: U R Reddy; S Pleasure; D Baker; Virginia M-Y Lee; Alonzo H Ross; David Pleasure
Primitive neuroectodermal tumors (PNETs) of the CNS and PNS that express functional nerve growth factor receptors (NGFR) but fail to differentiate in response to NGF.
Progress in clinical and biological research 1991;366():243-8.
1990: S J Pleasure; U R Reddy; G Venkatakrishnan; A K Roy; J Chen; Alonzo H Ross; John Q Trojanowski; David Pleasure; Virginia M-Y Lee
Introduction of nerve growth factor (NGF) receptors into a medulloblastoma cell line results in expression of high- and low-affinity NGF receptors but not NGF-mediated differentiation.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(21):8496-500.
1990: Laszlo Otvos; I A Tangoren; K Wroblewski; M Hollosi; Virginia M-Y Lee
Reversed-phase high-performance liquid chromatographic separation of synthetic phosphopeptide isomers.
Journal of chromatography 1990;512():265-72.
1990: S J Pleasure; Virginia M-Y Lee; D L Nelson
Site-specific phosphorylation of the middle molecular weight human neurofilament protein in transfected non-neuronal cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1990;10(7):2428-37.
1990: R A Stern; John Q Trojanowski; Virginia M-Y Lee
Antibodies to the beta-amyloid peptide cross-react with conformational epitopes in human fibrinogen subunits from peripheral blood.
FEBS letters 1990;264(1):43-7.
1990: M Luise Schmidt; Virginia M-Y Lee; John Q Trojanowski
Relative abundance of tau and neurofilament epitopes in hippocampal neurofibrillary tangles.
The American journal of pathology 1990;136(5):1069-75.
1990: Victor E Gould; D S Jansson; W M Molenaar; L B Rorke; John Q Trojanowski; Virginia M-Y Lee; R J Packer; W W Franke
Primitive neuroectodermal tumors of the central nervous system. Patterns of expression of neuroendocrine markers, and all classes of intermediate filament proteins.
Laboratory investigation; a journal of technical methods and pathology 1990;62(4):498-509.
1990: W M Molenaar; Virginia M-Y Lee; John Q Trojanowski
Early fetal acquisition of the chromaffin and neuronal immunophenotype by human adrenal medullary cells. An immunohistological study using monoclonal antibodies to chromogranin A, synaptophysin, tyrosine hydroxylase, and neuronal cytoskeletal proteins.
Experimental neurology 1990;108(1):1-9.
1990: Victor E Gould; L B Rorke; D S Jansson; W M Molenaar; John Q Trojanowski; Virginia M-Y Lee; R J Packer; W W Franke
Primitive neuroectodermal tumors of the central nervous system express neuroendocrine markers and may express all classes of intermediate filaments.
Human pathology 1990;21(3):245-52.
1990: Hanna Ksiezak-Reding; C H Chien; Virginia M-Y Lee; Shu-Hui C. Yen
Mapping of the Alz 50 epitope in microtubule-associated proteins tau.
Journal of neuroscience research 1990;25(3):412-9.
1990: Heii Arai; Virginia M-Y Lee; Laszlo Otvos; Barry D Greenberg; D E Lowery; S K Sharma; M Luise Schmidt; John Q Trojanowski
Defined neurofilament, tau, and beta-amyloid precursor protein epitopes distinguish Alzheimer from non-Alzheimer senile plaques.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(6):2249-53.
1990: W M Molenaar; D L Baker; David Pleasure; Virginia M-Y Lee; John Q Trojanowski
The neuroendocrine and neural profiles of neuroblastomas, ganglioneuroblastomas, and ganglioneuromas.
The American journal of pathology 1990;136(2):375-82.
1990: John Q Trojanowski; M Luise Schmidt; Laszlo Otvos; Heii Arai; William Hill; Virginia M-Y Lee
Vulnerability of the neuronal cytoskeleton in aging and Alzheimer disease: widespread involvement of all three major filament systems.
Annual review of gerontology & geriatrics 1990;10():167-82.
1989: W M Molenaar; D S Jansson; V E Gould; Lucy B Rorke; W W Franke; Virginia M-Y Lee; R J Packer; John Q Trojanowski
Molecular markers of primitive neuroectodermal tumors and other pediatric central nervous system tumors. Monoclonal antibodies to neuronal and glial antigens distinguish subsets of primitive neuroectodermal tumors.
Laboratory investigation; a journal of technical methods and pathology 1989;61(6):635-43.
1989: John Q Trojanowski; M L Kelsten; Virginia M-Y Lee
Phosphate-dependent and independent neurofilament protein epitopes are expressed throughout the cell cycle in human medulloblastoma (D283 MED) cells.
The American journal of pathology 1989;135(4):747-58.
1989: Laszlo Otvos; I Elekes; Virginia M-Y Lee
Solid-phase synthesis of phosphopeptides.
International journal of peptide and protein research 1989;34(2):129-33.
1989: K Mokuno; John Kamholz; T Behrman; C Black; M Sessa; D Feinstein; Virginia M-Y Lee; David Pleasure
Neuronal modulation of Schwann cell glial fibrillary acidic protein (GFAP).
Journal of neuroscience research 1989;23(4):396-405.
1989: John Q Trojanowski; Teresa Schuck; M Luise Schmidt; Virginia M-Y Lee
Distribution of phosphate-independent MAP2 epitopes revealed with monoclonal antibodies in microwave-denatured human nervous system tissues.
Journal of neuroscience methods 1989;29(2):171-80.
1989: B G Szaro; Virginia M-Y Lee; Harold Gainer
Spatial and temporal expression of phosphorylated and non-phosphorylated forms of neurofilament proteins in the developing nervous system of Xenopus laevis.
Brain research. Developmental brain research 1989;48(1):87-103.
1989: D M Wetzel; Virginia M-Y Lee; S D Erulkar
Long-term cultures of neurons from adult frog brain express GABA and glutamate-activated channels.
Journal of neurobiology 1989;20(4):255-70.
1989: R A Stern; L Otvos; John Q Trojanowski; Virginia M-Y Lee
Monoclonal antibodies to a synthetic peptide homologous with the first 28 amino acids of Alzheimer's disease beta-protein recognize amyloid and diverse glial and neuronal cell types in the central nervous system.
The American journal of pathology 1989;134(5):973-8.
1989: M Luise Schmidt; Virginia M-Y Lee; John Q Trojanowski
Analysis of epitopes shared by Hirano bodies and neurofilament proteins in normal and Alzheimer's disease hippocampus.
Laboratory investigation; a journal of technical methods and pathology 1989;60(4):513-22.
1989: Barbara R Talamo; R Rudel; Kenneth S Kosik; Virginia M-Y Lee; S Neff; L Adelman; John S Kauer
Pathological changes in olfactory neurons in patients with Alzheimer's disease.
Nature 1989;337(6209):736-9.
1989: S J Pleasure; M E Selzer; Virginia M-Y Lee
Lamprey neurofilaments combine in one subunit the features of each mammalian NF triplet protein but are highly phosphorylated only in large axons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1989;9(2):698-709.
1989: John Q Trojanowski; Teresa Schuck; M Luise Schmidt; Virginia M-Y Lee
Distribution of tau proteins in the normal human central and peripheral nervous system.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1989;37(2):209-15.
1989: M Hollosi; Laszlo Otvos; J Kajtar; A Percel; Virginia M-Y Lee
Is amyloid deposition in Alzheimer's disease preceded by an environment-induced double conformational transition?
Peptide research 1989;2(1):109-13.
1989: John Q Trojanowski; M Luise Schmidt; Laszlo Otvos; Ruben C Gur; R E Gur; Howard I Hurtig; Virginia M-Y Lee
Selective expression of epitopes in multiphosphorylation repeats of the high and middle molecular weight neurofilament proteins in Alzheimer neurofibrillary tangles.
Annals of medicine 1989;21(2):113-6.
1988: F S Kaplan; T G Maguire; Virginia M-Y Lee; M E Selzer; K Spindler; J Black; C T Brighton
Direct extracellular electrical stimulation influences density dependent aggregation of fetal rat cerebrocortical neurons in vitro.
Neuroscience letters 1988;94(1-2):33-8.
1988: Kenneth S Kosik; L D Orecchio; L Binder; John Q Trojanowski; Virginia M-Y Lee; Gloria Lee
Epitopes that span the tau molecule are shared with paired helical filaments.
Neuron 1988;1(9):817-25.
1988: Virginia M-Y Lee; Laszlo Otvos; M Luise Schmidt; John Q Trojanowski
Alzheimer disease tangles share immunological similarities with multiphosphorylation repeats in the two large neurofilament proteins.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(19):7384-8.
1988: M Luise Schmidt; Virginia M-Y Lee; Howard I Hurtig; John Q Trojanowski
Properties of antigenic determinants that distinguish neurofibrillary tangles in progressive supranuclear palsy and Alzheimer's disease.
Laboratory investigation; a journal of technical methods and pathology 1988;59(4):460-6.
1988: Mark M Black; Virginia M-Y Lee
Phosphorylation of neurofilament proteins in intact neurons: demonstration of phosphorylation in cell bodies and axons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1988;8(9):3296-305.
1988: Virginia M-Y Lee; Laszlo Otvos; M J Carden; M Hollosi; Bernhard Dietzschold; Robert A Lazzarini
Identification of the major multiphosphorylation site in mammalian neurofilaments.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(6):1998-2002.
1987: Virginia M-Y Lee
Perineurial cells can be grown in culture!
Laboratory investigation; a journal of technical methods and pathology 1987;57(5):451-2.
1987: M J Carden; John Q Trojanowski; William W Schlaepfer; Virginia M-Y Lee
Two-stage expression of neurofilament polypeptides during rat neurogenesis with early establishment of adult phosphorylation patterns.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1987;7(11):3489-504.
1987: Virginia M-Y Lee; M J Carden; William W Schlaepfer; John Q Trojanowski
Monoclonal antibodies distinguish several differentially phosphorylated states of the two largest rat neurofilament subunits (NF-H and NF-M) and demonstrate their existence in the normal nervous system of adult rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1987;7(11):3474-88.
1987: G A Foster; D Dahl; Virginia M-Y Lee
Temporal and topographic relationships between the phosphorylated and nonphosphorylated epitopes of the 200 kDa neurofilament protein during development in vitro.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1987;7(9):2651-63.
1987: M W Myers; R A Lazzarini; Virginia M-Y Lee; W W Schlaepfer; D L Nelson
The human mid-size neurofilament subunit: a repeated protein sequence and the relationship of its gene to the intermediate filament gene family.
The EMBO journal 1987;6(6):1617-26.
1987: M E Goldstein; Harry S Cooper; J Bruce; M J Carden; Virginia M-Y Lee; William W Schlaepfer
Phosphorylation of neurofilament proteins and chromatolysis following transection of rat sciatic nerve.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1987;7(5):1586-94.
1987: M L Schmidt; M J Carden; Virginia M-Y Lee; John Q Trojanowski
Phosphate dependent and independent neurofilament epitopes in the axonal swellings of patients with motor neuron disease and controls.
Laboratory investigation; a journal of technical methods and pathology 1987;56(3):282-94.
1986: F S Kaplan; C T Brighton; M J Boytim; Michael E Selzer; Virginia M-Y Lee; K Spindler; D Silberberg; J Black
Enhanced survival of rat neonatal cerebral cortical neurons at subatmospheric oxygen tensions in vitro.
Brain research 1986;384(1):199-203.
1986: Virginia M-Y Lee; M J Carden; William W Schlaepfer
Structural similarities and differences between neurofilament proteins from five different species as revealed using monoclonal antibodies.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1986;6(8):2179-86.
1986: M J Carden; Virginia M-Y Lee; William W Schlaepfer
2,5-Hexanedione neuropathy is associated with the covalent crosslinking of neurofilament proteins.
Neurochemical pathology 1986;5(1):25-35.
1986: John Q Trojanowski; B Atkinson; Virginia M-Y Lee
An immunocytochemical study of normal and abnormal human cerebrospinal fluid with monoclonal antibodies to glial fibrillary acidic protein.
Acta cytologica 1986;30(3):235-9.
1986: Barry Boyes; S U Kim; Virginia M-Y Lee; S C Sung
Immunohistochemical co-localization of S-100b and the glial fibrillary acidic protein in rat brain.
Neuroscience 1986;17(3):857-65.
1986: Virginia M-Y Lee; M J Carden; John Q Trojanowski
Novel monoclonal antibodies provide evidence for the in situ existence of a nonphosphorylated form of the largest neurofilament subunit.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1986;6(3):850-8.
1986: John Q Trojanowski; N Walkenstein; Virginia M-Y Lee
Expression of neurofilament subunits in neurons of the central and peripheral nervous system: an immunohistochemical study with monoclonal antibodies.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1986;6(3):650-60.
1986: Virginia M-Y Lee; P W Andrews
Differentiation of NTERA-2 clonal human embryonal carcinoma cells into neurons involves the induction of all three neurofilament proteins.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1986;6(2):514-21.
1986: S U Kim; G Moretto; Virginia M-Y Lee; Robert K Yu
Neuroimmunology of gangliosides in human neurons and glial cells in culture.
Journal of neuroscience research 1986;15(3):303-21.
1986: P D Garen; J M Powers; G F Young; Virginia M-Y Lee
Neuronal intranuclear hyaline inclusion disease in a nine year old.
Acta neuropathologica 1986;70(3-4):327-32.
1985: Virginia M-Y Lee
Neurofilament protein abnormalities in PC12 cells: comparison with neurofilament proteins of normal cultured rat sympathetic neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1985;5(11):3039-46.
1985: John Q Trojanowski; R A Stone; Virginia M-Y Lee
Presence of an alpha-melanocyte-stimulating hormone-like epitope in the 150,000 dalton neurofilament subunit from diverse regions of the central nervous system: an immunohistochemical and immunoblot study in guinea pig.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1985;33(9):900-4.
1985: M J Carden; William W Schlaepfer; Virginia M-Y Lee
The structure, biochemical properties, and immunogenicity of neurofilament peripheral regions are determined by phosphorylation state.
The Journal of biological chemistry 1985;260(17):9805-17.
1985: John Q Trojanowski; Virginia M-Y Lee
Expression of neurofilament antigens by normal and neoplastic human adrenal chromaffin cells.
The New England journal of medicine 1985;313(2):101-4.
1985: John Q Trojanowski; M A Obrocka; Virginia M-Y Lee
Distribution of neurofilament subunits in neurons and neuronal processes: immunohistochemical studies of bovine cerebellum with subunit-specific monoclonal antibodies.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1985;33(6):557-63.
1985: M L Schmidt; Virginia M-Y Lee; John Q Trojanowski
Immunochemical detection of diverse molecular species of horseradish peroxidase recovered from rat superior cervical ganglion following retrograde transport.
Brain research 1985;328(1):65-72.
1985: William W Schlaepfer; C Lee; Virginia M-Y Lee; Un-Jin Zimmerman
An immunoblot study of neurofilament degradation in situ and during calcium-activated proteolysis.
Journal of neurochemistry 1985;44(2):502-9.
1985: G F Tremblay; Virginia M-Y Lee; John Q Trojanowski
Expression of vimentin, glial filament, and neurofilament proteins in primitive childhood brain tumors. A comparative immunoblot and immunoperoxidase study.
Acta neuropathologica 1985;68(3):239-44.
1985: A E Bishop; F Carlei; Virginia M-Y Lee; John Q Trojanowski; P J Marangos; D Dahl; J M Polak
Combined immunostaining of neurofilaments, neuron specific enolase, GFAP and S-100. A possible means for assessing the morphological and functional status of the enteric nervous system.
Histochemistry 1985;82(1):93-7.
1985: Ruth Hogue Angeletti; John Q Trojanowski; M Carden; W W Schlaepfer; Virginia M-Y Lee
Domain structure of neurofilament subunits as revealed by monoclonal antibodies.
Journal of cellular biochemistry 1985;27(2):181-7.
1984: C Richter-Landsberg; Virginia M-Y Lee; S R Salton; Michael L. Shelanski; L A Greene
Release of the NILE and other glycoproteins from cultured PC12 rat pheochromocytoma cells and sympathetic neurons.
Journal of neurochemistry 1984;43(3):841-8.
1984: W W Schlaepfer; C Lee; John Q Trojanowski; Virginia M-Y Lee
Persistence of immunoreactive neurofilament protein breakdown products in transected rat sciatic nerve.
Journal of neurochemistry 1984;43(3):857-64.
1984: John Q Trojanowski; Virginia M-Y Lee; W W Schlaepfer
Neurofilament breakdown products in degenerating rat and human peripheral nerves.
Annals of neurology 1984;16(3):349-55.
1984: Virginia M-Y Lee; C Page
The dynamics of nerve growth factor-induced neurofilament and vimentin filament expression and organization in PC12 cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1984;4(7):1705-14.
1984: John Q Trojanowski; D Gordon; M Obrocka; Virginia M-Y Lee
The developmental expression of neurofilament and glial filament proteins in the human pituitary gland: an immunohistochemical study with monoclonal antibodies.
Brain research 1984;315(2):229-39.
1984: John Q Trojanowski; Virginia M-Y Lee; W W Schlaepfer
An immunohistochemical study of human central and peripheral nervous system tumors, using monoclonal antibodies against neurofilaments and glial filaments.
Human pathology 1984;15(3):248-57.
1984: Virginia M-Y Lee; C D Page; H L Wu; W W Schlaepfer
Monoclonal antibodies to gel-excised glial filament protein and their reactivities with other intermediate filament proteins.
Journal of neurochemistry 1984;42(1):25-32.
1983: John Q Trojanowski; M A Obrocka; Virginia M-Y Lee
A comparison of eight different chromogen protocols for the demonstration of immunoreactive neurofilaments or glial filaments in rat cerebellum using the peroxidase-antiperoxidase method and monoclonal antibodies.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1983;31(10):1217-23.
1983: W F Hickey; Virginia M-Y Lee; John Q Trojanowski; L J McMillan; T J McKearn; J Gonatas; N K Gonatas
Immunohistochemical application of monoclonal antibodies against myelin basic protein and neurofilament triple protein subunits: advantages over antisera and technical limitations.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1983;31(9):1126-35.
1983: John Q Trojanowski; Virginia M-Y Lee
Monoclonal and polyclonal antibodies against neural antigens: diagnostic applications for studies of central and peripheral nervous system tumors.
Human pathology 1983;14(4):281-5.
1983: John Q Trojanowski; Virginia M-Y Lee
Anti-neurofilament monoclonal antibodies: reagents for the evaluation of human neoplasms.
Acta neuropathologica 1983;59(2):155-8.
1982: Virginia M-Y Lee; H L Wu; W W Schlaepfer
Monoclonal antibodies recognize individual neurofilament triplet proteins.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(19):6089-92.
1982: John Q Trojanowski; Virginia M-Y Lee; N Pillsbury; S Lee
Neuronal origin of human esthesioneuroblastoma demonstrated with anti-neurofilament monoclonal antibodies.
The New England journal of medicine 1982;307(3):159-61.
1982: Virginia M-Y Lee; John Q Trojanowski; W W Schlaepfer
Induction of neurofilament triplet proteins in PC12 cells by nerve growth factor.
Brain research 1982;238(1):169-80.
1981: W W Schlaepfer; Virginia M-Y Lee; H L Wu
Assessment of immunological properties of neurofilament triplet proteins.
Brain research 1981;226(1-2):259-72.
1981: Virginia M-Y Lee; L Greene; Michael L. Shelanski
Identification of neural and adrenal medullary surface membrane glycoproteins recognized by antisera to cultured rat sympathetic neurons and PC12 pheochromocytoma cells.
Neuroscience 1981;6(12):2773-86.
1980: Virginia M-Y Lee; L A Greene; Michael L. Shelanski
Difference cytotoxic activities of antisera against nerve growth factor-treated and untreated clonal pheochromocytoma cells.
Neuroscience 1980;5(11):1979-87.
1980: Virginia M-Y Lee; Michael L. Shelanski; L A Greene
Characterization of antisera raised against cultured rat sympathetic neurons.
Neuroscience 1980;5(12):2239-45.
1977: Virginia M-Y Lee; Michael L. Shelanski; L A Greene
Specific neural and adrenal medullary antigens detected by antisera to clonal PC12 pheochromocytoma cells.
Proceedings of the National Academy of Sciences of the United States of America 1977;74(11):5021-5.
1977: Virginia M-Y Lee; Shu-Hui C. Yen; Michael L. Shelanski
Biochemical correlates of astrocytic proliferation in the mutant Staggerer mouse.
Brain research 1977;128(2):389-92.
1977: P M Beart; Virginia M-Y Lee
Transmitter enzymes in Weaver and Staggerer neurological mutant mice.
Brain research 1977;124(1):171-7.