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William Lee
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Research Profile (preview)
Chemicals & Drugs
Concepts & Ideas
Procedures
Living Beings
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Network (preview)
17
Cundy, Kenneth
11
Shaw, JP
5
Oliyai, R
5
Visor, GC
4
Arimilli, MN
3
Jones, RJ
2
Bidgood, AM
2
Liu, Xiaohong
2
Cihlar, Tomas
2
Mulato, Andrew
2
Chen, James
2
Swaminathan, Swami
2
Yuan, LC
1
Van Rompay, Koen
1
Vela, Jennifer
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Geonetwork of William Lee (preview)
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All Publications
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2009: Durand-Gasselin Lucie; Van Rompay Koen K A; Vela Jennifer E; Henne Ilana N; Lee William A; Rhodes Gerry R; Ray Adrian S
Nucleotide analogue prodrug tenofovir disoproxil enhances lymphoid cell loading following oral administration in monkeys.
Molecular pharmaceutics 2009;6(4):1145-51.
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2006: Cihlar Tomas; He Gong-Xin; Liu Xiaohong; Chen James M; Hatada Marcos; Swaminathan Swami; McDermott Martin J; Yang Zheng-Yu; Mulato Andrew S; Chen Xiaowu; Leavitt Stephanie A; Stray Kirsten M; Lee William A
Suppression of HIV-1 protease inhibitor resistance by phosphonate-mediated solvent anchoring.
Journal of molecular biology 2006;363(3):635-47.
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2006: Lee William A; Martin John C
Perspectives on the development of acyclic nucleotide analogs as antiviral drugs.
Antiviral research 2006;71(2-3):254-9.
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2006: Watkins William J; Chen James M; Cho Aesop; Chong Lee; Collins Nicole; Fardis Maria; Huang Wei; Hung Magdeleine; Kirschberg Thorsten; Lee William A; Liu Xiaohong; Thomas William; Xu Jie; Zeynalzadegan Ameneh; Zhang Jennifer
Phosphonic acid-containing analogues of mycophenolic acid as inhibitors of IMPDH.
Bioorganic & medicinal chemistry letters 2006;16(13):3479-83.
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2005: Lee William A; He Gong-Xin; Eisenberg Eugene; Cihlar Tomas; Swaminathan Swami; Mulato Andrew; Cundy Kenneth C
Selective intracellular activation of a novel prodrug of the human immunodeficiency virus reverse transcriptase inhibitor tenofovir leads to preferential distribution and accumulation in lymphatic tissue.
Antimicrobial agents and chemotherapy 2005;49(5):1898-906.
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2001: Ennis R D; Pritchard R; Nakamura C; Coulon M; Yang T; Visor G C; Lee W A
Glass vials for small volume parenterals: influence of drug and manufacturing processes on glass delamination.
Pharmaceutical development and technology 2001;6(3):393-405.
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2001: Oliyai R; Arimilli M N; Jones R J; Lee W A
Pharmacokinetics of salicylate ester prodrugs of cyclic HPMPC in dogs.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):1411-4.
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1999: Oliyai R; Shaw J P; Sueoka-Lennen C M; Cundy K C; Arimilli M N; Jones R J; Lee W A
Aryl ester prodrugs of cyclic HPMPC. I: Physicochemical characterization and in vitro biological stability.
Pharmaceutical research 1999;16(11):1687-93.
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1999: Oliyai R; Lee W A; Visor G C; Yuan L C
Enhanced chemical stability of the intracellular prodrug, 1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl]cytosine, relative to its parent compound, cidofovir.
International journal of pharmaceutics 1999;179(2):257-65.
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1998: Lacy S A; Hitchcock M J; Lee W A; Tellier P; Cundy K C
Effect of oral probenecid coadministration on the chronic toxicity and pharmacokinetics of intravenous cidofovir in cynomolgus monkeys.
Toxicological sciences : an official journal of the Society of Toxicology 1998;44(2):97-106.
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1998: Oliyai R; Yuan L C; Dahl T C; Swaminathan S; Wang K Y; Lee W A
Biexponential decomposition of a neuraminidase inhibitor prodrug (GS-4104) in aqueous solution.
Pharmaceutical research 1998;15(8):1300-4.
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1998: Cundy K C; Sueoka C; Lynch G R; Griffin L; Lee W A; Shaw J P
Pharmacokinetics and bioavailability of the anti-human immunodeficiency virus nucleotide analog 9-[(R)-2-(phosphonomethoxy)propyl]adenine (PMPA) in dogs.
Antimicrobial agents and chemotherapy 1998;42(3):687-90.
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1997: Shaw J P; Sueoko C M; Oliyai R; Lee W A; Arimilli M N; Kim C U; Cundy K C
Metabolism and pharmacokinetics of novel oral prodrugs of 9-[(R)-2-(phosphonomethoxy)propyl]adenine (PMPA) in dogs.
Pharmaceutical research 1997;14(12):1824-9.
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1997: Cundy K C; Sue I L; Visor G C; Marshburn J; Nakamura C; Lee W A; Shaw J P
Oral formulations of adefovir dipivoxil: in vitro dissolution and in vivo bioavailability in dogs.
Journal of pharmaceutical sciences 1997;86(12):1334-8.
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1997: Cundy K C; Lynch G; Lee W A
Bioavailability and metabolism of cidofovir following topical administration to rabbits.
Antiviral research 1997;35(2):113-22.
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1997: Shaw J P; Louie M S; Krishnamurthy V V; Arimilli M N; Jones R J; Bidgood A M; Lee W A; Cundy K C
Pharmacokinetics and metabolism of selected prodrugs of PMEA in rats.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(3):362-6.
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1996: Cundy K C; Bidgood A M; Lynch G; Shaw J P; Griffin L; Lee W A
Pharmacokinetics, bioavailability, metabolism, and tissue distribution of cidofovir (HPMPC) and cyclic HPMPC in rats.
Drug metabolism and disposition: the biological fate of chemicals 1996;24(7):745-52.
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1996: Cundy K C; Li Z H; Hitchcock M J; Lee W A
Pharmacokinetics of cidofovir in monkeys. Evidence for a prolonged elimination phase representing phosphorylated drug.
Drug metabolism and disposition: the biological fate of chemicals 1996;24(7):738-44.
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1996: Cundy K C; Lynch G; Shaw J P; Hitchcock M J; Lee W A
Distribution and metabolism of intravitreal cidofovir and cyclic HPMPC in rabbits.
Current eye research 1996;15(5):569-76.
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1996: Cundy K C; Li Z H; Lee W A
Effect of probenecid on the distribution, metabolism, and excretion of cidofovir in rabbits.
Drug metabolism and disposition: the biological fate of chemicals 1996;24(3):315-21.
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1995: Lee W A; Fishback J A; Shaw J P; Bock L C; Griffin L C; Cundy K C
A novel oligodeoxynucleotide inhibitor of thrombin. II. Pharmacokinetics in the cynomolgus monkey.
Pharmaceutical research 1995;12(12):1943-7.
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1995: Shaw J P; Fishback J A; Cundy K C; Lee W A
A novel oligodeoxynucleotide inhibitor of thrombin. I. In vitro metabolic stability in plasma and serum.
Pharmaceutical research 1995;12(12):1937-42.
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1995: Aspe E; Guy R H; Lee W A; Kennedy J A; Visor G C; Ennis R D
Optimization of in vitro flux through hairless mouse skin of cidofovir, a potent nucleotide analog.
Journal of pharmaceutical sciences 1995;84(6):750-4.
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1994: Bischofberger N; Hitchcock M J; Chen M S; Barkhimer D B; Cundy K C; Kent K M; Lacy S A; Lee W A; Li Z H; Mendel D B
1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl] cytosine, an intracellular prodrug for (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine with improved therapeutic index in vivo.
Antimicrobial agents and chemotherapy 1994;38(10):2387-91.
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1994: Cundy K C; Fishback J A; Shaw J P; Lee M L; Soike K F; Visor G C; Lee W A
Oral bioavailability of the antiretroviral agent 9-(2-phosphonylmethoxyethyl)adenine (PMEA) from three formulations of the prodrug bis(pivaloyloxymethyl)-PMEA in fasted male cynomolgus monkeys.
Pharmaceutical research 1994;11(6):839-43.
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1994: Lee W A; Ennis R D; Longenecker J P; Bengtsson P
The bioavailability of intranasal salmon calcitonin in healthy volunteers with and without a permeation enhancer.
Pharmaceutical research 1994;11(5):747-50.
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1994: Cundy K C; Shaw J P; Lee W A
Oral, subcutaneous, and intramuscular bioavailabilities of the antiviral nucleotide analog 9-(2-phosphonylmethoxyethyl) adenine in cynomolgus monkeys.
Antimicrobial agents and chemotherapy 1994;38(2):365-8.
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1990: Ennis R D; Borden L; Lee W A
The effects of permeation enhancers on the surface morphology of the rat nasal mucosa: a scanning electron microscopy study.
Pharmaceutical research 1990;7(5):468-75.
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