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Fredrik Leeb-Lundberg

Research Profile

Chemicals & Drugs

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Physiology

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Stefan Broselid; Benxu Cheng; Mårten Fernö; Linda Hartman; Karin Jirström; Heather L P Klug-De Santiago; Kristina Lövgren; Per Malmström; Björn Olde; Martin Sjöström; Mattias Belting; Pär-Ola Bendahl; L M Fredrik Leeb-Lundberg
G protein-coupled estrogen receptor is apoptotic and correlates with increased distant disease-free survival of estrogen receptor-positive breast cancer patients.
Caroline Sandén; L M Fredrik Leeb-Lundberg
Kinin B1 receptor homo-oligomerization is required for receptor trafficking to the cell surface.
Anders Holm; L M Fredrik Leeb-Lundberg; Richard F Ludueña; Björn Olde; Veena Prasad; Per-Olof Grände; Bengt-Olof Nilsson
The G protein-coupled oestrogen receptor 1 agonist G-1 disrupts endothelial cell microtubule structure in a receptor-independent manner.

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2013: Stefan Broselid; Benxu Cheng; Mårten Fernö; Linda Hartman; Karin Jirström; Heather L P Klug-De Santiago; Kristina Lövgren; Per Malmström; Björn Olde; Martin Sjöström; Mattias Belting; Pär-Ola Bendahl; L M Fredrik Leeb-Lundberg
G protein-coupled estrogen receptor is apoptotic and correlates with increased distant disease-free survival of estrogen receptor-positive breast cancer patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 2013;19(7):1681-92.
2013: Caroline Sandén; L M Fredrik Leeb-Lundberg
Kinin B1 receptor homo-oligomerization is required for receptor trafficking to the cell surface.
International immunopharmacology 2013;15(1):121-8.
2012: Anders Holm; L M Fredrik Leeb-Lundberg; Richard F Ludueña; Björn Olde; Veena Prasad; Per-Olof Grände; Bengt-Olof Nilsson
The G protein-coupled oestrogen receptor 1 agonist G-1 disrupts endothelial cell microtubule structure in a receptor-independent manner.
Molecular and cellular biochemistry 2012;366(1-2):239-49.
2011: Caroline Sandén; Stefan Broselid; Louise Cornmark; Krister Andersson; Joanna Daszkiewicz-Nilsson; Ulrika E A Mårtensson; Björn Olde; L M Fredrik Leeb-Lundberg
G protein-coupled estrogen receptor 1/G protein-coupled receptor 30 localizes in the plasma membrane and traffics intracellularly on cytokeratin intermediate filaments.
Molecular pharmacology 2011;79(3):400-10.
2011: Anders Holm; L M Fredrik Leeb-Lundberg; Bo Baldetorp; Björn Olde; Bengt-Olof Nilsson
The GPER1 agonist G-1 attenuates endothelial cell proliferation by inhibiting DNA synthesis and accumulating cells in the S and G2 phases of the cell cycle.
Journal of vascular research 2011;48(4):327-35.
2009: Björn Olde; L M Fredrik Leeb-Lundberg
GPR30/GPER1: searching for a role in estrogen physiology.
Trends in endocrinology and metabolism: TEM 2009;20(8):409-16.
2009: Robin Kahn; Thomas Hellmark; L M Fredrik Leeb-Lundberg; Nasrin Akbari; Mihail Todiras; Tor Olofsson; Jörgen Wieslander; Anders Christensson; Kerstin Westman; Michael Bader; Werner Müller-Esterl; Diana Karpman
Neutrophil-derived proteinase 3 induces kallikrein-independent release of a novel vasoactive kinin.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(12):7906-15.
2009: Ulrika E A Mårtensson; S Albert Salehi; Sara Windahl; Maria F Gomez; Karl Swärd; Joanna Daszkiewicz-Nilsson; Anna Wendt; Niklas Andersson; Per Hellstrand; Per-Olof Grände; Christer Owman; Clifford J Rosen; Martin Adamo; Ingmar Lundquist; Patrik Rorsman; Bengt-Olof Nilsson; Claes Ohlsson; Björn Olde; L M Fredrik Leeb-Lundberg
Deletion of the G protein-coupled receptor 30 impairs glucose tolerance, reduces bone growth, increases blood pressure, and eliminates estradiol-stimulated insulin release in female mice.
Endocrinology 2009;150(2):687-98.
2009: Sara H Bengtson; Caroline Sandén; Matthias Mörgelin; Pauline F Marx; Anders I Olin; L M Fredrik Leeb-Lundberg; Joost C M Meijers; Heiko Herwald
Activation of TAFI on the surface of Streptococcus pyogenes evokes inflammatory reactions by modulating the kallikrein/kinin system.
Journal of innate immunity 2009;1(1):18-28.
2008: Caroline Sandén; Johan Enquist; Sara H Bengtson; Heiko Herwald; L M Fredrik Leeb-Lundberg
Kinin B2 receptor-mediated bradykinin internalization and metalloendopeptidase EP24.15-dependent intracellular bradykinin degradation.
The Journal of pharmacology and experimental therapeutics 2008;326(1):24-32.
2007: Johan Enquist; Carl Skröder; Jennifer L Whistler; L M Fredrik Leeb-Lundberg
Kinins promote B2 receptor endocytosis and delay constitutive B1 receptor endocytosis.
Molecular pharmacology 2007;71(2):494-507.
2006: Sara H Bengtson; Stephen B Phagoo; Anna Norrby-Teglund; Lisa Påhlman; Matthias Mörgelin; Bruce L Zuraw; L M Fredrik Leeb-Lundberg; Heiko Herwald
Kinin receptor expression during Staphylococcus aureus infection.
Blood 2006;108(6):2055-63.
2006: Knut Kotarsky; Ake Boketoft; Jesper Bristulf; Niclas E Nilsson; Ake Norberg; Stefan Hansson; Christer Owman; Rannar Sillard; L M Fredrik Leeb-Lundberg; Björn Olde
Lysophosphatidic acid binds to and activates GPR92, a G protein-coupled receptor highly expressed in gastrointestinal lymphocytes.
The Journal of pharmacology and experimental therapeutics 2006;318(2):619-28.
2006: L M Fredrik Leeb-Lundberg
Exploring the future of local vascular and inflammatory mediators.
Biological chemistry 2006;387(2):117-8.
2005: Stephen B Phagoo; Krisanavane Reddi; Bertrand J Silvallana; L M Fredrik Leeb-Lundberg; David Warburton
Infection-induced kinin B1 receptors in human pulmonary fibroblasts: role of intact pathogens and p38 mitogen-activated protein kinase-dependent signaling.
The Journal of pharmacology and experimental therapeutics 2005;313(3):1231-8.
2005: L M Fredrik Leeb-Lundberg; Francois Marceau; Werner Müller-Esterl; Douglas J Pettibone; Bruce L Zuraw
International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences.
Pharmacological reviews 2005;57(1):27-77.
2005: Dong Soo Kang; Caroline Gustafsson; Matthias Mörgelin; L M Fredrik Leeb-Lundberg
B1 bradykinin receptor homo-oligomers in receptor cell surface expression and signaling: effects of receptor fragments.
Molecular pharmacology 2005;67(1):309-18.
2004: L M Fredrik Leeb-Lundberg
Bradykinin specificity and signaling at GPR100 and B2 kinin receptors.
British journal of pharmacology 2004;143(8):931-2.
2004: Dong Soo Kang; Kristina Ryberg; Matthias Mörgelin; L M Fredrik Leeb-Lundberg
Spontaneous formation of a proteolytic B1 and B2 bradykinin receptor complex with enhanced signaling capacity.
The Journal of biological chemistry 2004;279(21):22102-7.
2004: Deborah M Holstein; Kelly Berg; L M Fredrik Leeb-Lundberg; Merle S Olson; Christine Saunders
Calcium-sensing receptor-mediated ERK1/2 activation requires Galphai2 coupling and dynamin-independent receptor internalization.
The Journal of biological chemistry 2004;279(11):10060-9.
2003: Jason S Taub; Rishu Guo; L M Fredrik Leeb-Lundberg; John F Madden; Yehia A Daaka
Bradykinin receptor subtype 1 expression and function in prostate cancer.
Cancer research 2003;63(9):2037-41.
2003: Liza Barki-Harrington; Angela L Bookout; Gaofeng Wang; Maria E Lamb; L M Fredrik Leeb-Lundberg; Yehia A Daaka
Requirement for direct cross-talk between B1 and B2 kinin receptors for the proliferation of androgen-insensitive prostate cancer PC3 cells.
The Biochemical journal 2003;371(Pt 2):581-7.
2003: David M Lefler; Yurii V Mukhin; Tobiah Pettus; L M Fredrik Leeb-Lundberg; Maria N Garnovskaya; John R Raymond
Jak2 and Ca2+/calmodulin are key intermediates for bradykinin B2 receptor-mediated activation of Na+/H+ exchange in KNRK and CHO cells.
Assay and drug development technologies 2003;1(2):281-9.
2002: Maria E Lamb; Chongwu Zhang; Thomas Shea; Donald J Kyle; L M Fredrik Leeb-Lundberg
Human B1 and B2 bradykinin receptors and their agonists target caveolae-related lipid rafts to different degrees in HEK293 cells.
Biochemistry 2002;41(48):14340-7.
2002: Dong Soo Kang; L M Fredrik Leeb-Lundberg
Negative and positive regulatory epitopes in the C-terminal domains of the human B1 and B2 bradykinin receptor subtypes determine receptor coupling efficacy to G(q/11)-mediated [correction of G(9/11)-mediated] phospholipase Cbeta activity.
Molecular pharmacology 2002;62(2):281-8.
2002: Lucia Carvelli; José A Morón; Kristopher M Kahlig; Jasmine V Ferrer; Namita Sen; James D Lechleiter; L M Fredrik Leeb-Lundberg; Gerald A Merrill; Eileen M Lafer; Lisa M Ballou; Toni S Shippenberg; Jonathan A Javitch; Richard Z Lin; Aurelio Galli
PI 3-kinase regulation of dopamine uptake.
Journal of neurochemistry 2002;81(4):859-69.
2001: Stephen B Phagoo; Krisanavane Reddi; Kathryn D Anderson; L M Fredrik Leeb-Lundberg; David Warburton
Bradykinin B1 receptor up-regulation by interleukin-1beta and B1 agonist occurs through independent and synergistic intracellular signaling mechanisms in human lung fibroblasts.
The Journal of pharmacology and experimental therapeutics 2001;298(1):77-85.
2001: Maria E Lamb; W F De Weerd; L M Fredrik Leeb-Lundberg
Agonist-promoted trafficking of human bradykinin receptors: arrestin- and dynamin-independent sequestration of the B2 receptor and bradykinin in HEK293 cells.
The Biochemical journal 2001;355(Pt 3):741-50.
2001: L M Fredrik Leeb-Lundberg; Dong Soo Kang; Maria E Lamb; DB Fathy
The human B1 bradykinin receptor exhibits high ligand-independent, constitutive activity. Roles of residues in the fourth intracellular and third transmembrane domains.
The Journal of biological chemistry 2001;276(12):8785-92.
2000: C Saunders; Jasmine V Ferrer; Lei Shi; J Chen; Gerald A Merrill; M E Lamb; L M Fredrik Leeb-Lundberg; Lucia Carvelli; Jonathan A Javitch; Aurelio Galli
Amphetamine-induced loss of human dopamine transporter activity: an internalization-dependent and cocaine-sensitive mechanism.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(12):6850-5.
2000: DB Fathy; D J Kyle; L M Fredrik Leeb-Lundberg
High-affinity binding of peptide agonists to the human B1 bradykinin receptor depends on interaction between the peptide N-terminal L-lysine and the fourth extracellular domain of the receptor.
Molecular pharmacology 2000;57(1):171-9.
1999: DB Fathy; T Leeb; SA Mathis; L M Fredrik Leeb-Lundberg
Spontaneous human B2 bradykinin receptor activity determines the action of partial agonists as agonists or inverse agonists. Effect of basal desensitization.
The Journal of biological chemistry 1999;274(42):29603-6.
1999: Stephen B Phagoo; S Poole; L M Fredrik Leeb-Lundberg
Autoregulation of bradykinin receptors: agonists in the presence of interleukin-1beta shift the repertoire of receptor subtypes from B2 to B1 in human lung fibroblasts.
Molecular pharmacology 1999;56(2):325-33.
1998: DB Fathy; SA Mathis; T Leeb; L M Fredrik Leeb-Lundberg
A single position in the third transmembrane domains of the human B1 and B2 bradykinin receptors is adjacent to and discriminates between the C-terminal residues of subtype-selective ligands.
The Journal of biological chemistry 1998;273(20):12210-8.
1997: W F de Weerd; L M Fredrik Leeb-Lundberg
Bradykinin sequesters B2 bradykinin receptors and the receptor-coupled Galpha subunits Galphaq and Galphai in caveolae in DDT1 MF-2 smooth muscle cells.
The Journal of biological chemistry 1997;272(28):17858-66.
1997: T Leeb; SA Mathis; L M Fredrik Leeb-Lundberg
The sixth transmembrane domains of the human B1 and B2 bradykinin receptors are structurally compatible and involved in discriminating between subtype-selective agonists.
The Journal of biological chemistry 1997;272(1):311-7.
1996: M C Herzig; N R Nash; M Connolly; D J Kyle; L M Fredrik Leeb-Lundberg
The N terminus of bradykinin when bound to the human bradykinin B2 receptor is adjacent to extracellular Cys20 and Cys277 in the receptor.
The Journal of biological chemistry 1996;271(47):29746-51.
1996: T N Hembree; L M Fredrik Leeb-Lundberg
Regulation of bradykinin B2 receptors by the ras oncogene: evidence for multiple mechanisms.
Journal of cellular physiology 1996;169(2):248-55.
1996: S A Mathis; N L Criscimagna; L M Fredrik Leeb-Lundberg
B1 and B2 kinin receptors mediate distinct patterns of intracellular Ca2+ signaling in single cultured vascular smooth muscle cells.
Molecular pharmacology 1996;50(1):128-39.
1995: M C Herzig; L M Fredrik Leeb-Lundberg
The agonist binding site on the bovine bradykinin B2 receptor is adjacent to a sulfhydryl and is differentiated from the antagonist binding site by chemical cross-linking.
The Journal of biological chemistry 1995;270(35):20591-8.
1994: L M Fredrik Leeb-Lundberg; S A Mathis; M C Herzig
Antagonists of bradykinin that stabilize a G-protein-uncoupled state of the B2 receptor act as inverse agonists in rat myometrial cells.
The Journal of biological chemistry 1994;269(42):25970-3.
1994: L M Fredrik Leeb-Lundberg; X H Song; S A Mathis
Focal adhesion-associated proteins p125FAK and paxillin are substrates for bradykinin-stimulated tyrosine phosphorylation in Swiss 3T3 cells.
The Journal of biological chemistry 1994;269(39):24328-34.
1993: Bradley S McAllister; L M Fredrik Leeb-Lundberg; Martin A Javors; Merle S Olson
Bradykinin receptors and signal transduction pathways in human fibroblasts: integral role for extracellular calcium.
Archives of biochemistry and biophysics 1993;304(1):294-301.
1993: L M Fredrik Leeb-Lundberg; X H Song
Identification of p125, a component of a group of 120-kDa proteins that are phosphorylated on tyrosine residues in response to bradykinin and bombesin stimulation, in anti-ras-GTPase-activating protein immunoprecipitates of Swiss 3T3 cells.
The Journal of biological chemistry 1993;268(11):8151-7.
1993: C M Munoz; S Cotecchia; L M Fredrik Leeb-Lundberg
B2 kinin receptor-mediated internalization of bradykinin in DDT1 MF-2 smooth muscle cells is paralleled by sequestration of the occupied receptors.
Archives of biochemistry and biophysics 1993;301(2):336-44.
1993: M M Tropea; D Gummelt; M S Herzig; L M Fredrik Leeb-Lundberg
B1 and B2 kinin receptors on cultured rabbit superior mesenteric artery smooth muscle cells: receptor-specific stimulation of inositol phosphate formation and arachidonic acid release by des-Arg9-bradykinin and bradykinin.
The Journal of pharmacology and experimental therapeutics 1993;264(2):930-7.
1992: M M Tropea; C M Munoz; L M Fredrik Leeb-Lundberg
Bradykinin binding to B2 kinin receptors and stimulation of phosphoinositide turnover and arachidonic acid release in primary cultures of cells from late pregnant rat myometrium.
Canadian journal of physiology and pharmacology 1992;70(10):1360-71.
1992: C M Munoz; L M Fredrik Leeb-Lundberg
Receptor-mediated internalization of bradykinin. DDT1 MF-2 smooth muscle cells process internalized bradykinin via multiple degradative pathways.
The Journal of biological chemistry 1992;267(1):303-9.
1991: S A Mathis; L M Fredrik Leeb-Lundberg
Bradykinin recognizes different molecular forms of the B2 kinin receptor in the presence and absence of guanine nucleotides.
The Biochemical journal 1991;276 ( Pt 1)():141-7.
1991: L M Fredrik Leeb-Lundberg; X H Song
Bradykinin and bombesin rapidly stimulate tyrosine phosphorylation of a 120-kDa group of proteins in Swiss 3T3 cells.
The Journal of biological chemistry 1991;266(12):7746-9.
1990: L M Fredrik Leeb-Lundberg; S A Mathis
Guanine nucleotide regulation of B2 kinin receptors. Time-dependent formation of a guanine nucleotide-sensitive receptor state from which [3H]bradykinin dissociates slowly.
The Journal of biological chemistry 1990;265(17):9621-7.
1987: J L Benovic; John W Regan; H Matsui; F Mayor; S Cotecchia; L M Fredrik Leeb-Lundberg; Marc G Caron; R J Lefkowitz
Agonist-dependent phosphorylation of the alpha 2-adrenergic receptor by the beta-adrenergic receptor kinase.
The Journal of biological chemistry 1987;262(36):17251-3.
1987: L M Fredrik Leeb-Lundberg; S Cotecchia; A DeBlasi; Marc G Caron; R J Lefkowitz
Regulation of adrenergic receptor function by phosphorylation. I. Agonist-promoted desensitization and phosphorylation of alpha 1-adrenergic receptors coupled to inositol phospholipid metabolism in DDT1 MF-2 smooth muscle cells.
The Journal of biological chemistry 1987;262(7):3098-105.
1986: J W Lomasney; L M Fredrik Leeb-Lundberg; S Cotecchia; John W Regan; J F DeBernardis; Marc G Caron; R J Lefkowitz
Mammalian alpha 1-adrenergic receptor. Purification and characterization of the native receptor ligand binding subunit.
The Journal of biological chemistry 1986;261(17):7710-6.
1986: K E Dickinson; L M Fredrik Leeb-Lundberg; R H Strasser; Marc G Caron; R J Lefkowitz
Identification of the subunit structure of rat pineal adrenergic receptors by photoaffinity labeling.
Journal of neurochemistry 1986;46(4):1153-60.
1985: S Cotecchia; L M Fredrik Leeb-Lundberg; P O Hagen; R J Lefkowitz; Marc G Caron
Phorbol ester effects on alpha 1-adrenoceptor binding and phosphatidylinositol metabolism in cultured vascular smooth muscle cells.
Life sciences 1985;37(25):2389-98.
1985: L M Fredrik Leeb-Lundberg; S Cotecchia; J W Lomasney; J F DeBernardis; R J Lefkowitz; Marc G Caron
Phorbol esters promote alpha 1-adrenergic receptor phosphorylation and receptor uncoupling from inositol phospholipid metabolism.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(17):5651-5.
1984: Marc G Caron; L M Fredrik Leeb-Lundberg; C D Strader; K E Dickinson; V M Pickel; T Joh; R J Lefkowitz
Molecular biology of adrenergic receptors in the rat and frog central nervous system.
Hypertension 1984;6(5 Pt 2):II22-7.
1984: K E Dickinson; L M Fredrik Leeb-Lundberg; S L Heald; J E Wikberg; J F DeBernardis; Marc G Caron; R J Lefkowitz
Photoaffinity cross-linking of a radioiodinated probe, 125I-A55453, into alpha 1-adrenergic receptors.
Molecular pharmacology 1984;26(2):187-95.
1984: L M Fredrik Leeb-Lundberg; K E Dickinson; S L Heald; J E Wikberg; P O Hagen; J F DeBernardis; Martin Winn; D L Arendsen; R J Lefkowitz; Marc G Caron
Photoaffinity labeling of mammalian alpha 1-adrenergic receptors. Identification of the ligand binding subunit with a high affinity radioiodinated probe.
The Journal of biological chemistry 1984;259(4):2579-87.
1983: L M Fredrik Leeb-Lundberg; K E Dickinson; S L Heald; J E Wikberg; J F DeBernardis; Martin Winn; D L Arendsen; R J Lefkowitz; Marc G Caron
Covalent labeling of the cerebral cortex alpha 1-adrenergic receptor with a new high affinity radioiodinated photoaffinity probe.
Biochemical and biophysical research communications 1983;115(3):946-51.