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Kennedy Lees

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Azmil H Abdul-Rahim; Kennedy R Lees
Paroxysmal atrial fibrillation after ischemic stroke: how should we hunt for it?
Alex Bottle; Hilary P Grocott; Kennedy R Lees; Abdul Mozid; Paul Aylin; Matthew R Walters; Robert D Sanders
Preoperative stroke and outcomes after coronary artery bypass graft surgery.
Benedikt Frank; James C Grotta; Kennedy R Lees; Patrick Lyden; Atte Meretoja; Nishant K Mishra; Ashfaq Shuaib; Nils G Wahlgren; Christian Weimar; Andrei V Alexandrov; Erich Bluhmki
Thrombolysis in stroke despite contraindications or warnings?

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2013: Azmil H Abdul-Rahim; Kennedy R Lees
Paroxysmal atrial fibrillation after ischemic stroke: how should we hunt for it?
Expert review of cardiovascular therapy 2013;11(4):485-94.
2013: Alex Bottle; Hilary P Grocott; Kennedy R Lees; Abdul Mozid; Paul Aylin; Matthew R Walters; Robert D Sanders
Preoperative stroke and outcomes after coronary artery bypass graft surgery.
Anesthesiology 2013;118(4):885-93.
2013: Benedikt Frank; James C Grotta; Kennedy R Lees; Patrick Lyden; Atte Meretoja; Nishant K Mishra; Ashfaq Shuaib; Nils G Wahlgren; Christian Weimar; Andrei V Alexandrov; Erich Bluhmki
Thrombolysis in stroke despite contraindications or warnings?
Stroke; a journal of cerebral circulation 2013;44(3):727-33.
2013: Kennedy R Lees; Gilad Rosenberg; Ashfaq Shuaib; Natan Bornstein; Hans-Christoph Diener; Philip B Gorelick
Results of Membrane-Activated Chelator Stroke Intervention randomized trial of DP-b99 in acute ischemic stroke.
Stroke; a journal of cerebral circulation 2013;44(3):580-4.
2013: Timothy C Morgan; Terence J Quinn; Mark Rafferty; Danielle Spengler; Matthew R Walters; Christopher J Weir; Wendy C Ziai; Chanel Aldrich; Issam Awad; Jesse Dawson; Marie Diener-West; Daniel F Hanley; Peter Higgins; Katie Kinsley; Karen Lane; Kennedy R Lees; Nishant K Mishra
The Modified Graeb Score: an enhanced tool for intraventricular hemorrhage measurement and prediction of functional outcome.
Stroke; a journal of cerebral circulation 2013;44(3):635-41.
2012: Martin Pitt; Ken Stein; David Worthington; Paritosh Agarwal; Gary A Ford; Kennedy R Lees; Thomas Monks; Martin A James
Will delays in treatment jeopardize the population benefit from extending the time window for stroke thrombolysis?
Stroke; a journal of cerebral circulation 2012;43(11):2992-7.
2012: Peter Higgins; Kennedy R Lees; Kate McArthur; Terrence J Quinn; Jesse Dawson; Matthew R Walters
Xanthine oxidase inhibition for the treatment of cardiovascular disease: a systematic review and meta-analysis.
Cardiovascular therapeutics 2012;30(4):217-26.
2012: Jesse Dawson; Kennedy R Lees; Terry Quinn; Matthew R Walters
Microembolic signals and aspirin resistance in patients with carotid stenosis.
Cardiovascular therapeutics 2012;30(4):234-9.
2012: Benedikt Frank; Rachael Fulton; Kennedy R Lees; Ashfaq Shuaib; Christian Weimar
Impact of atrial fibrillation on outcome in thrombolyzed patients with stroke: evidence from the Virtual International Stroke Trials Archive (VISTA).
Stroke; a journal of cerebral circulation 2012;43(7):1872-7.
2012: Graeme J Hankey; Kennedy R Lees; Jose C Navarro; Udaya K Ranawaka; Stefano Ricci; Reinhold Schmidt; Wasim Uddin; Denis Xavier; Qilong Yi; Christopher Chen; John W Eikelboom; John Gommans
Antiplatelet therapy and the effects of B vitamins in patients with previous stroke or transient ischaemic attack: a post-hoc subanalysis of VITATOPS, a randomised, placebo-controlled trial.
Lancet neurology 2012;11(6):512-20.
2012: Graeme J Hankey; Kennedy R Lees; Jose C Navarro; Udaya K Ranawaka; Stefano Ricci; Reinhold Schmidt; Wasim Uddin; Denis Xavier; Qilong Yi; Christopher Chen; John W Eikelboom; John Gommans
Treatment with B vitamins and incidence of cancer in patients with previous stroke or transient ischemic attack: results of a randomized placebo-controlled trial.
Stroke; a journal of cerebral circulation 2012;43(6):1572-7.
2012: Michael Mazya; Robert Mikulik; Danilo Toni; Nils Gunnar Wahlgren; Niaz Ahmed; José A Egido; Gary A Ford; Kennedy R Lees
Predicting the risk of symptomatic intracerebral hemorrhage in ischemic stroke treated with intravenous alteplase: safe Implementation of Treatments in Stroke (SITS) symptomatic intracerebral hemorrhage risk score.
Stroke; a journal of cerebral circulation 2012;43(6):1524-31.
2012: Robert D Sanders; Matthew Walters; Abdul Mozid; Mike R Reed; Paul Aylin; Alex Bottle; Lliam Edger; Simon S Jameson; Kennedy R Lees; Daqing Ma; Mervyn Maze
Independent preoperative predictors of outcomes in orthopedic and vascular surgery: the influence of time interval between an acute coronary syndrome or stroke and the operation.
Annals of surgery 2012;255(5):901-7.
2012: Daniel M Kerr; Kennedy R Lees
Letter by Kerr and Lees regarding article, "country comparisons of human stroke research since 2001: a bibliometric study".
Stroke; a journal of cerebral circulation 2012;43(5):e52.
2012: Daniel M Kerr; Kennedy R Lees; Rachael L Fulton
Seven-day NIHSS is a sensitive outcome measure for exploratory clinical trials in acute stroke: evidence from the Virtual International Stroke Trials Archive.
Stroke; a journal of cerebral circulation 2012;43(5):1401-3.
2012: Philip M W Bath; Martin Bland; Cheryl Hogg; George Howard; Kennedy R Lees; Jeffrey L Saver; Peter D Schellinger; Hernan Altman
Statistical analysis of the primary outcome in acute stroke trials.
Stroke; a journal of cerebral circulation 2012;43(4):1171-8.
2012: Kennedy R Lees; David Matchar; Peter D Schellinger; Ruchir Sehra; Danilo Toni; Philip M W Bath; Rachael Fulton; Werner Hacke; Daniel M Kerr
Contemporary outcome measures in acute stroke research: choice of primary outcome measure.
Stroke; a journal of cerebral circulation 2012;43(4):1163-70.
2012: George Howard; Virginia J Howard; Edward C Jauch; Kennedy R Lees; Fenwick T Nichols; Volker W Rahlfs; Jenifer H Voeks; Jennifer L Waller; David C Hess
A simple, assumption-free, and clinically interpretable approach for analysis of modified Rankin outcomes.
Stroke; a journal of cerebral circulation 2012;43(3):664-9.
2012: Myzoon Ali; Philip Bath; M Brady; Stephen Davis; Hans-Christoph Diener; Geoffrey Donnan; Marc Fisher; Werner Hacke; Daniel F Hanley; Kennedy R Lees; Marie Luby; G Tsivgoulis; Nils Wahlgren; Steven Warach
Development, expansion, and use of a stroke clinical trials resource for novel exploratory analyses.
International journal of stroke : official journal of the International Stroke Society 2012;7(2):133-8.
2012: Daniel M Kerr; Kennedy R Lees; Patrick Lyden; Ashfaq Shuaib; Philip M W Bath; Rachael L Fulton; Peter Higgins
Response of blood pressure and blood glucose to treatment with recombinant tissue-type plasminogen activator in acute ischemic stroke: evidence from the virtual international stroke trials archive.
Stroke; a journal of cerebral circulation 2012;43(2):399-404.
2011: Jesse Dawson; Peter Higgins; Kennedy R Lees; Terry Quinn; Mark Rafferty; Gautamanda Ray; Matthew R Walters
Aspirin resistance and compliance with therapy.
Cardiovascular therapeutics 2011;29(5):301-7.
2011: Karim Hajjar; Daniel M Kerr; Kennedy R Lees
Thrombolysis for acute ischemic stroke.
Journal of vascular surgery 2011;54(3):901-7.
2011: Alan C Cameron; Jesse Dawson; Gordon T McInnes; David Morrison; Terence J Quinn; William Sloan; Matthew R Walters; Kennedy R Lees
Long-term outcome following attendance at a transient ischemic attack clinic.
International journal of stroke : official journal of the International Stroke Society 2011;6(4):306-11.
2011: Daniel M Kerr; Kennedy R Lees
Should thrombolysis be recommended for diabetic stroke patients?
Expert review of cardiovascular therapy 2011;9(4):409-12.
2011: Nishant K Mishra; Ashfaq Shuaib; Patrick Lyden; Hans-Christoph Diener; James Grotta; Stephen Davis; Antoni Davalos; Tim Ashwood; Warren Wasiewski; Kennedy R Lees
Home time is extended in patients with ischemic stroke who receive thrombolytic therapy: a validation study of home time as an outcome measure.
Stroke; a journal of cerebral circulation 2011;42(4):1046-50.
2011: Hans T H Tu; Bruce C V Campbell; Leonid Churilov; Stephen M Davis; Geoffrey A Donnan; Jonathan M Kalman; Kennedy R Lees; Patrick D Lyden; Ashfaq Shuaib
Frequent early cardiac complications contribute to worse stroke outcome in atrial fibrillation.
Cerebrovascular diseases (Basel, Switzerland) 2011;32(5):454-60.
2010: Myzoon Ali; Ann Ashburn; Audrey Bowen; Eric Brodie; Susan Corr; Avril Drummond; Judi Edmans; John Gladman; Lalit Kalra; Peter Langhorne; Kennedy R Lees; Nadina Lincoln; Pip Logan; Gillian Mead; Emma Patchick; Alex Pollock; Val Pomeroy; Catherine Sackley; Katharina Sunnerhagen; Paulette van Vliet; Marion Walker; M Brady
VISTA-Rehab: a resource for stroke rehabilitation trials.
International journal of stroke : official journal of the International Stroke Society 2010;5(6):447-52.
2010: Nishant Kumar Mishra; Hans-Christoph Diener; Patrick D Lyden; Erich Bluhmki; Kennedy R Lees
Influence of age on outcome from thrombolysis in acute stroke: a controlled comparison in patients from the Virtual International Stroke Trials Archive (VISTA).
Stroke; a journal of cerebral circulation 2010;41(12):2840-8.
2010: Terence J Quinn; Kate McArthur; Jesse Dawson; Matthew R Walters; Kennedy R Lees
Reliability of structured modified rankin scale assessment.
Stroke; a journal of cerebral circulation 2010;41(12):e602; author reply e603.
2010: Nishant Kumar Mishra; Stephen M Davis; Markku Kaste; Kennedy R Lees
Comparison of outcomes following thrombolytic therapy among patients with prior stroke and diabetes in the Virtual International Stroke Trials Archive (VISTA).
Diabetes care 2010;33(12):2531-7.
2010: Nishant Kumar Mishra; Patrick D Lyden; James C Grotta; Kennedy R Lees
Thrombolysis is associated with consistent functional improvement across baseline stroke severity: a comparison of outcomes in patients from the Virtual International Stroke Trials Archive (VISTA).
Stroke; a journal of cerebral circulation 2010;41(11):2612-7.
2010: Niaz Ahmed; Antoni Dávalos; Niclas Eriksson; Gary A Ford; Joerg Glahn; Michael Hennerici; Robert Mikulik; Markku Kaste; Kennedy R Lees; Perttu J Lindsberg; Danilo Toni
Association of admission blood glucose and outcome in patients treated with intravenous thrombolysis: results from the Safe Implementation of Treatments in Stroke International Stroke Thrombolysis Register (SITS-ISTR).
Archives of neurology 2010;67(9):1123-30.
2010: Niaz Ahmed; Nils Wahlgren; Martin Grond; Michael Hennerici; Kennedy R Lees; Robert Mikulik; Mark Parsons; Risto O Roine; Danilo Toni; Peter Ringleb
Implementation and outcome of thrombolysis with alteplase 3-4.5 h after an acute stroke: an updated analysis from SITS-ISTR.
Lancet neurology 2010;9(9):866-74.
2010: J K Harrison; B Sloan; J Dawson; Kennedy R Lees; D S Morrison
The ABCD and ABCD2 as predictors of stroke in transient ischemic attack clinic outpatients: a retrospective cohort study over 14 years.
QJM : monthly journal of the Association of Physicians 2010;103(9):679-85.
2010: Kennedy R Lees; Erich Bluhmki; Rüdiger von Kummer; Thomas G Brott; Danilo Toni; James C Grotta; Gregory W Albers; Markku Kaste; John R Marler; Scott A Hamilton; Barbara C Tilley; Stephen M Davis; Geoffrey A Donnan; Werner Hacke; Kathryn Allen; Jochen Mau; Dieter Meier; Gregory del Zoppo; D A De Silva; K S Butcher; M W Parsons; P A Barber; C Levi; C Bladin; G Byrnes
Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials.
Lancet 2010;375(9727):1695-703.
2010: Christian Weimar; M Ali; Kennedy R Lees; E Bluhmki; G A Donnan; Hans-Christoph Diener
The Virtual International Stroke Trials Archive (VISTA): results and impact on future stroke trials and management of stroke patients.
International journal of stroke : official journal of the International Stroke Society 2010;5(2):103-9.
2010: M Ali; E Jüttler; Kennedy R Lees; Werner Hacke; J Diedler
Patient outcomes in historical comparators compared with randomised-controlled trials.
International journal of stroke : official journal of the International Stroke Society 2010;5(1):10-5.
2010: Kate McArthur; Kennedy R Lees
Advances in emerging therapies 2009.
Stroke; a journal of cerebral circulation 2010;41(2):e67-70.
2010: Jennifer Diedler; Niaz Ahmed; Marek Sykora; Maarten Uyttenboogaart; Karsten Overgaard; Gert-Jan Luijckx; Lauri Soinne; Gary A Ford; Kennedy R Lees; Nils-Gunnar Wahlgren; Peter A Ringleb
Safety of intravenous thrombolysis for acute ischemic stroke in patients receiving antiplatelet therapy at stroke onset.
Stroke; a journal of cerebral circulation 2010;41(2):288-94.
2010: Nishant K Mishra; Niaz Ahmed; Grethe Andersen; José A Egido; Perttu J Lindsberg; Peter A Ringleb; Nils G Wahlgren; Kennedy R Lees
Thrombolysis in very elderly people: controlled comparison of SITS International Stroke Thrombolysis Registry and Virtual International Stroke Trials Archive.
BMJ (Clinical research ed.) 2010;341():c6046.
2010: Nishant Kumar Mishra; Gregory W Albers; Stephen M Davis; Geoffrey A Donnan; Anthony J Furlan; Werner Hacke; Kennedy R Lees
Mismatch-based delayed thrombolysis: a meta-analysis.
Stroke; a journal of cerebral circulation 2010;41(1):e25-33.
2009: M Ali; Ralph L Sacco; Kennedy R Lees
Primary end-point times, functional outcome and adverse event profile after acute ischaemic stroke.
International journal of stroke : official journal of the International Stroke Society 2009;4(6):432-42.
2009: Jesse Dawson; Terrence J Quinn; Craig Harrow; Kennedy R Lees; Matthew R Walters
The effect of allopurinol on the cerebral vasculature of patients with subcortical stroke; a randomized trial.
British journal of clinical pharmacology 2009;68(5):662-8.
2009: Hooman Kamel; Kennedy R Lees; Patrick D Lyden; Philip A Teal; Ashfaq Shuaib; Myzoon Ali; S Claiborne Johnston
Delayed detection of atrial fibrillation after ischemic stroke.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2009;18(6):453-7.
2009: Terence J Quinn; Jesse Dawson; Matthew R Walters; Kennedy R Lees
Reliability of the modified Rankin Scale: a systematic review.
Stroke; a journal of cerebral circulation 2009;40(10):3393-5.
2009: Monica Saini; Maher Saqqur; Anmmd Kamruzzaman; Kennedy R Lees; Ashfaq Shuaib
Effect of hyperthermia on prognosis after acute ischemic stroke.
Stroke; a journal of cerebral circulation 2009;40(9):3051-9.
2009: Brett L Cucchiara; Scott E Kasner; David Tanne; Steven R Levine; Andrew M Demchuk; Steven R Messe; Lauren Sansing; Kennedy R Lees; Patrick D Lyden
Factors associated with intracerebral hemorrhage after thrombolytic therapy for ischemic stroke: pooled analysis of placebo data from the Stroke-Acute Ischemic NXY Treatment (SAINT) I and SAINT II Trials.
Stroke; a journal of cerebral circulation 2009;40(9):3067-72.
2009: Kennedy R Lees
Training and consistency in stroke assessments.
Stroke; a journal of cerebral circulation 2009;40(7):2297.
2009: Niaz Ahmed; Nils Gunnar Wahlgren; Michael Brainin; José Castillo; Gary A Ford; Markku Kaste; Kennedy R Lees; Danilo Toni
Relationship of blood pressure, antihypertensive therapy, and outcome in ischemic stroke treated with intravenous thrombolysis: retrospective analysis from Safe Implementation of Thrombolysis in Stroke-International Stroke Thrombolysis Register (SITS-ISTR).
Stroke; a journal of cerebral circulation 2009;40(7):2442-9.
2009: Terence J Quinn; Jesse Dawson; Matthew R Walters; Kennedy R Lees
Functional outcome measures in contemporary stroke trials.
International journal of stroke : official journal of the International Stroke Society 2009;4(3):200-5.
2009: Peter Higgins; Kennedy R Lees
Advances in emerging therapies.
Stroke; a journal of cerebral circulation 2009;40(5):e292-4.
2009: Chelsea S Kidwell; Kennedy R Lees; Keith W Muir; Christopher Chen; Stephen M Davis; Deidre A De Silva; Christopher J Weir; Sidney Starkman; Jeffry R Alger; Jeffrey Saver
Results of the MRI substudy of the intravenous magnesium efficacy in stroke trial.
Stroke; a journal of cerebral circulation 2009;40(5):1704-9.
2009: M Ali; P Lyden; Ralph L Sacco; A Shuaib; Kennedy R Lees
Natural history of complications after intracerebral haemorrhage.
European journal of neurology : the official journal of the European Federation of Neurological Societies 2009;16(5):624-30.
2009: Kennedy R Lees
PRoFESS.
Stroke; a journal of cerebral circulation 2009;40(5):1941.
2009: Terence J Quinn; Alan C Cameron; Jesse Dawson; Kennedy R Lees; Matthew R Walters
ABCD2 scores and prediction of noncerebrovascular diagnoses in an outpatient population: a case-control study.
Stroke; a journal of cerebral circulation 2009;40(3):749-53.
2009: Terence J Quinn; Jesse Dawson; Matthew R Walters; Kennedy R Lees
Exploring the reliability of the modified rankin scale.
Stroke; a journal of cerebral circulation 2009;40(3):762-6.
2009: Terence J Quinn; Stefano Paolucci; Katharina Sunnerhagen; Juhani Sivenius; Marion F Walker; Danilo Toni; Kennedy R Lees
Evidence-based stroke r-ehabilitation: an expanded guidance document from the european stroke organisation (ESO) guidelines for management of ischaemic stroke and transient ischaemic attack 2008.
Journal of rehabilitation medicine : official journal of the UEMS European Board of Physical and Rehabilitation Medicine 2009;41(2):99-111.
2009: Jesse Dawson; Kennedy R Lees; Christopher J Weir; Terry Quinn; Myzoon Ali; Michael G Hennerici; Matthew R Walters
Baseline serum urate and 90-day functional outcomes following acute ischemic stroke.
Cerebrovascular diseases (Basel, Switzerland) 2009;28(2):202-3.
2009: T J Quinn; Kennedy R Lees
Hyperglycaemia in acute stroke--to treat or not to treat.
Cerebrovascular diseases (Basel, Switzerland) 2009;27 Suppl 1():148-55.
2009: Jesse Dawson; Terry Quinn; Craig Harrow; Kennedy R Lees; Christopher J Weir; Stephen J Cleland; Matthew R Walters
Allopurinol and nitric oxide activity in the cerebral circulation of those with diabetes: a randomized trial.
Diabetes care 2009;32(1):135-7.
2009: Myzoon Ali; Sari Atula; Philip Bath; James Grotta; Werner Hacke; Patrick Lyden; John R Marler; Ralph L Sacco; Kennedy R Lees
Stroke outcome in clinical trial patients deriving from different countries.
Stroke; a journal of cerebral circulation 2009;40(1):35-40.
2008: Peter Higgins; Sandip Ghosh; Kennedy R Lees
Improving mortality from stroke disease: putting the evidence into practice.
British journal of hospital medicine (London, England : 2005) 2008;69(12):668-9.
2008: John N Fink; Christopher M Frampton; Patrick Lyden; Kennedy R Lees
Does hemispheric lateralization influence functional and cardiovascular outcomes after stroke?: an analysis of placebo-treated patients from prospective acute stroke trials.
Stroke; a journal of cerebral circulation 2008;39(12):3335-40.
2008: Nils Wahlgren; Niaz Ahmed; Niclas Eriksson; Franz Aichner; Erich Bluhmki; Antoni Dávalos; Terttu Erilä; Gary A Ford; Martin Grond; Werner Hacke; Michael G Hennerici; Markku Kaste; Martin Köhrmann; Vincent Larrue; Kennedy R Lees; Thomas Machnig; Risto O Roine; Danilo Toni; Geert Vanhooren
Multivariable analysis of outcome predictors and adjustment of main outcome results to baseline data profile in randomized controlled trials: Safe Implementation of Thrombolysis in Stroke-MOnitoring STudy (SITS-MOST).
Stroke; a journal of cerebral circulation 2008;39(12):3316-22.
2008: Scott Muir; Craig Harrow; Jesse Dawson; Kennedy R Lees; Christopher J Weir; Naveed Sattar; Matthew R Walters
Allopurinol use yields potentially beneficial effects on inflammatory indices in those with recent ischemic stroke: a randomized, double-blind, placebo-controlled trial.
Stroke; a journal of cerebral circulation 2008;39(12):3303-7.
2008: Terence J Quinn; Gautamananda Ray; Sari Atula; Matthew R Walters; Jesse Dawson; Kennedy R Lees
Deriving modified Rankin scores from medical case-records.
Stroke; a journal of cerebral circulation 2008;39(12):3421-3.
2008: Kennedy R Lees; Gary A Ford; Keith W Muir; N Ahmed; Alexander G Dyker; S Atula; Lalit Kalra; E A Warburton; J-C Baron; D F Jenkinson; N G Wahlgren; M R Walters
Thrombolytic therapy for acute stroke in the United Kingdom: experience from the safe implementation of thrombolysis in stroke (SITS) register.
QJM : monthly journal of the Association of Physicians 2008;101(11):863-9.
2008: Terence J Quinn; Jesse Dawson; Matthew R Walters; Kennedy R Lees
Variability in modified Rankin scoring across a large cohort of international observers.
Stroke; a journal of cerebral circulation 2008;39(11):2975-9.
2008: Nils Gunnar Wahlgren; Niaz Ahmed; Antoni Dávalos; Werner Hacke; Mónica Millán; Keith Muir; Risto O Roine; Danilo Toni; Kennedy R Lees
Thrombolysis with alteplase 3-4.5 h after acute ischaemic stroke (SITS-ISTR): an observational study.
Lancet 2008;372(9646):1303-9.
2008: Werner Hacke; Markku Kaste; Erich Bluhmki; Miroslav Brozman; Antoni Dávalos; Donata Guidetti; Vincent Larrue; Kennedy R Lees; Zakaria Medeghri; Thomas Machnig; Dietmar Schneider; Rüdiger von Kummer; Nils Wahlgren; Danilo Toni
Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke.
The New England journal of medicine 2008;359(13):1317-29.
2008: Hans-Christoph Diener; Kennedy R Lees; Patrick Lyden; Jim Grotta; Antoni Davalos; Stephen M Davis; Ashfaq Shuaib; Tim Ashwood; Warren Wasiewski; Vivian Alderfer; Hans-Goran Hårdemark; Larry Rodichok
NXY-059 for the treatment of acute stroke: pooled analysis of the SAINT I and II Trials.
Stroke; a journal of cerebral circulation 2008;39(6):1751-8.
2008: Terence J Quinn; Jesse Dawson; Kennedy R Lees
Past, present and future of alteplase for acute ischemic stroke.
Expert review of neurotherapeutics 2008;8(2):181-92.
2008: Terence J Quinn; Kennedy R Lees
Advances in emerging therapies 2007.
Stroke; a journal of cerebral circulation 2008;39(2):255-7.
2008: Jesse Dawson; Clifford Weir; F Wright; C Bryden; Stella Aslanyan; Kennedy R Lees; W Bird; Matthew Walters
Associations between meteorological variables and acute stroke hospital admissions in the west of Scotland.
Acta neurologica Scandinavica 2008;117(2):85-9.
2008: Clotilde Lecrux; Christopher McCabe; Christopher J Weir; Lindsay Gallagher; Jim Mullin; Omar Touzani; Keith W Muir; Kennedy R Lees; I Mhairi Macrae
Effects of magnesium treatment in a model of internal capsule lesion in spontaneously hypertensive rats.
Stroke; a journal of cerebral circulation 2008;39(2):448-54.
2008: Jesse Dawson; Terry Quinn; Kennedy R Lees; Matthew Walters
The continued yin and yang of uric acid.
Stroke; a journal of cerebral circulation 2008;39(1):e9; author reply e10.
2008: Terence J Quinn; Jesse Dawson; Jennifer S Lees; Tou-Pin Chang; Matthew R Walters; Kennedy R Lees
Time spent at home poststroke: "home-time" a meaningful and robust outcome measure for stroke trials.
Stroke; a journal of cerebral circulation 2008;39(1):231-3.
2007: Terence J Quinn; Jesse Dawson; Matthew R Walters; Kennedy R Lees
Reliability of the modified Rankin Scale.
Stroke; a journal of cerebral circulation 2007;38(11):e144; author reply e145.
2007: Ashfaq Shuaib; Kennedy R Lees; Patrick D Lyden; James C Grotta; Antonio Davalos; Stephen M Davis; Hans-Christoph Diener; Tim Ashwood; Warren W Wasiewski; Ugochi Emeribe
NXY-059 for the treatment of acute ischemic stroke.
The New England journal of medicine 2007;357(6):562-71.
2007: Terence J Quinn; Kennedy R Lees; Hans-Goran Hardemark; Jesse Dawson; Matthew R Walters
Initial experience of a digital training resource for modified Rankin scale assessment in clinical trials.
Stroke; a journal of cerebral circulation 2007;38(8):2257-61.
2007: Jane Prosser; Lachlan MacGregor; Kennedy R Lees; Hans-Christoph Diener; Werner Hacke; Stephen Davis
Predictors of early cardiac morbidity and mortality after ischemic stroke.
Stroke; a journal of cerebral circulation 2007;38(8):2295-302.
2007: Patrick D Lyden; Ashfaq Shuaib; Kennedy R Lees; Antonio Davalos; Stephen M Davis; Hans-Christoph Diener; James C Grotta; Tim Ashwood; Hans-Goran Hardemark; Hannah H Svensson; Larry Rodichok; Warren W Wasiewski; Gabrielle Ahlberg
Safety and tolerability of NXY-059 for acute intracerebral hemorrhage: the CHANT Trial.
Stroke; a journal of cerebral circulation 2007;38(8):2262-9.
2007: Jesse Dawson; Jennifer S Lees; Tou-Pin Chang; Matthew R Walters; Myzoon Ali; Stephen M Davis; Hans-Christoph Diener; Kennedy R Lees
Association between disability measures and healthcare costs after initial treatment for acute stroke.
Stroke; a journal of cerebral circulation 2007;38(6):1893-8.
2007: Myzoon Ali; Philip Bath; John Curram; Stephen M Davis; Hans-Christoph Diener; Geoffrey A Donnan; Marc Fisher; Barbara A Gregson; James C Grotta; Werner Hacke; Michael G Hennerici; Marc Hommel; Markku Kaste; John R Marler; Ralph L Sacco; Philip Teal; Nils-Gunnar Wahlgren; Steven Warach; Christopher J Weir; Kennedy R Lees
The Virtual International Stroke Trials Archive.
Stroke; a journal of cerebral circulation 2007;38(6):1905-10.
2007: Stella Aslanyan; Christopher J Weir; Keith W Muir; Kennedy R Lees
Magnesium for treatment of acute lacunar stroke syndromes: further analysis of the IMAGES trial.
Stroke; a journal of cerebral circulation 2007;38(4):1269-73.
2007: Kennedy R Lees; Jesse Dawson
Advances in emerging therapies 2006.
Stroke; a journal of cerebral circulation 2007;38(2):219-21.
2007: Nils Wahlgren; Niaz Ahmed; Antoni Dávalos; Gary A Ford; Martin Grond; Werner Hacke; Michael G Hennerici; Markku Kaste; Sonja Kuelkens; Vincent Larrue; Kennedy R Lees; Risto O Roine; Lauri Soinne; Danilo Toni; Geert Vanhooren
Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST): an observational study.
Lancet 2007;369(9558):275-82.
2007: Terence J Quinn; Jesse Dawson; Kennedy R Lees
Acute stroke: we have the treatments and we have the evidence--we need to use them.
Critical care (London, England) 2007;11(2):124.
2007: Stella Aslanyan; Christopher J Weir; C S Johnston; Michael Krams; Andrew P Grieve; Kennedy R Lees
The association of post-stroke neurological improvement with risk of subsequent deterioration due to stroke events.
European journal of neurology : the official journal of the European Federation of Neurological Societies 2007;14(1):1-6.
2006: Kennedy R Lees; Antonio Davalos; Stephen M Davis; Hans-Christoph Diener; James C Grotta; Patrick D Lyden; Ashfaq Shuaib; Tim Ashwood; Hans-Goran Hardemark; Warren W Wasiewski; Ugochi Emeribe; Justin A Zivin
Additional outcomes and subgroup analyses of NXY-059 for acute ischemic stroke in the SAINT I trial.
Stroke; a journal of cerebral circulation 2006;37(12):2970-8.
2006: Patrick D Lyden; Kennedy R Lees; Stephen M Davis
Alteplase for acute stroke revisited: the first 10 years.
Lancet neurology 2006;5(9):722-4.
2006: Hisatomi Arima; Christophe Tzourio; Ken Butcher; Craig Anderson; Marie-Germaine Bousser; Kennedy R Lees; John L Reid; Teruo Omae; Mark Woodward; Stephen MacMahon; John Chalmers
Prior events predict cerebrovascular and coronary outcomes in the PROGRESS trial.
Stroke; a journal of cerebral circulation 2006;37(6):1497-502.
2006: Anthony J Furlan; Dirk Eyding; Gregory W Albers; Yasir Al-Rawi; Kennedy R Lees; Howard A Rowley; Christian Sachara; Mariola Soehngen; Steven Warach; Werner Hacke
Dose Escalation of Desmoteplase for Acute Ischemic Stroke (DEDAS): evidence of safety and efficacy 3 to 9 hours after stroke onset.
Stroke; a journal of cerebral circulation 2006;37(5):1227-31.
2006: Kennedy R Lees; Paolo Milia
Halving effort in acute stroke trials.
Clinical and experimental hypertension (New York, N.Y. : 1993) 2006;28(3-4):309-12.
2006: Fozia S Nazir; Mohammed A S Alem; Michael Small; John M C Connell; Kennedy R Lees; Matthew R Walters; Stephen J Cleland
Blunted response to systemic nitric oxide synthase inhibition in the cerebral circulation of patients with Type 2 diabetes.
Diabetic medicine : a journal of the British Diabetic Association 2006;23(4):398-402.
2006: Ralf Dittrich; Martin A Ritter; Manfred Kaps; Mario Siebler; Kennedy R Lees; Vincent Larrue; Darius Günther Nabavi; E Bernd Ringelstein; Hugh S Markus; Dirk W Droste
The use of embolic signal detection in multicenter trials to evaluate antiplatelet efficacy: signal analysis and quality control mechanisms in the CARESS (Clopidogrel and Aspirin for Reduction of Emboli in Symptomatic carotid Stenosis) trial.
Stroke; a journal of cerebral circulation 2006;37(4):1065-9.
2006: Paolo Milia; Scott Muir; Mohammed A S Alem; Kennedy R Lees; Matthew Walters
Comparison of the effect of diuretics on carotid blood flow in stroke patients.
Journal of cardiovascular pharmacology 2006;47(3):446-9.
2006: Kennedy R Lees; Justin A Zivin; Tim Ashwood; Antonio Davalos; Stephen M Davis; Hans-Christoph Diener; James C Grotta; Patrick D Lyden; Ashfaq Shuaib; Hans-Göran Hårdemark; Warren W Wasiewski
NXY-059 for acute ischemic stroke.
The New England journal of medicine 2006;354(6):588-600.
2006: Matthew R Walters; Christopher J Weir; Kennedy R Lees
A randomised, controlled pilot study to investigate the potential benefit of intervention with insulin in hyperglycaemic acute ischaemic stroke patients.
Cerebrovascular diseases (Basel, Switzerland) 2006;22(2-3):116-22.
2006: Bruce Ovbiagele; Christopher J Weir; Jeffrey Saver; Keith W Muir; Kennedy R Lees
Effect of smoking status on outcome after acute ischemic stroke.
Cerebrovascular diseases (Basel, Switzerland) 2006;21(4):260-5.
2006: Steven Warach; David Kaufman; David Chiu; Thomas Devlin; Marie Luby; Ajaz Rashid; Linda Clayton; Markku Kaste; Kennedy R Lees; Ralph L Sacco; Marc Fisher
Effect of the Glycine Antagonist Gavestinel on cerebral infarcts in acute stroke patients, a randomized placebo-controlled trial: The GAIN MRI Substudy.
Cerebrovascular diseases (Basel, Switzerland) 2006;21(1-2):106-11.
2006: Edward J Newman; Fariel S Rahman; Kennedy R Lees; Christopher J Weir; Matthew R Walters
Elevated serum urate concentration independently predicts poor outcome following stroke in patients with diabetes.
Diabetes/metabolism research and reviews 2006;22(1):79-82.
2005: Matthew R Walters; Christopher J Weir; F G Adams; Kennedy R Lees
The prognostic significance of visible infarction on computed tomography following lacunar stroke: results of a long-term follow-up study.
Journal of neuroimaging : official journal of the American Society of Neuroimaging 2005;15(4):331-5.
2005: Fiona B Young; Christopher J Weir; Kennedy R Lees
Comparison of the National Institutes of Health Stroke Scale with disability outcome measures in acute stroke trials.
Stroke; a journal of cerebral circulation 2005;36(10):2187-92.
2005: Stella Aslanyan; Christopher J Weir; Gordon T McInnes; John L Reid; Matthew R Walters; Kennedy R Lees
Statin administration prior to ischaemic stroke onset and survival: exploratory evidence from matched treatment-control study.
European journal of neurology : the official journal of the European Federation of Neurological Societies 2005;12(7):493-8.
2005: C A L Bain; Kennedy R Lees; Mary Ann Lumsden; Matthew R Walters
Effect of a gonadotropin releasing hormone analog on cerebral hemodynamics in premenopausal women.
Climacteric : the journal of the International Menopause Society 2005;8(2):193-7.
2005: Michael Krams; Kennedy R Lees; Donald A Berry
The past is the future: innovative designs in acute stroke therapy trials.
Stroke; a journal of cerebral circulation 2005;36(6):1341-7.
2005: Hugh S Markus; Dirk W Droste; Manfred Kaps; Vincent Larrue; Kennedy R Lees; Mario Siebler; E Bernd Ringelstein
Dual antiplatelet therapy with clopidogrel and aspirin in symptomatic carotid stenosis evaluated using doppler embolic signal detection: the Clopidogrel and Aspirin for Reduction of Emboli in Symptomatic Carotid Stenosis (CARESS) trial.
Circulation 2005;111(17):2233-40.
2005: Gordon D Murray; David Barer; Sung Choi; Helen M Fernandes; Barbara A Gregson; Kennedy R Lees; Andrew I.R. Maas; Anthony Marmarou; David Mendelow; Ewout W Steyerberg; Gillian S Taylor; Graham M Teasdale; Christopher J Weir
Design and analysis of phase III trials with ordered outcome scales: the concept of the sliding dichotomy.
Journal of neurotrauma 2005;22(5):511-7.
2005: E Clarke Haley; John L P Thompson; Bruce Levin; Stephen Davis; Kennedy R Lees; John G Pittman; Janet T DeRosa; Paul Ordronneau; Devin L Brown; Ralph L Sacco
Gavestinel does not improve outcome after acute intracerebral hemorrhage: an analysis from the GAIN International and GAIN Americas studies.
Stroke; a journal of cerebral circulation 2005;36(5):1006-10.
2005: Fiona B Young; Kennedy R Lees; Christopher J Weir
Improving trial power through use of prognosis-adjusted end points.
Stroke; a journal of cerebral circulation 2005;36(3):597-601.
2005: Fozia S Nazir; Kennedy R Lees; I Bone
Clinical features associated with medically unexplained stroke-like symptoms presenting to an acute stroke unit.
European journal of neurology : the official journal of the European Federation of Neurological Societies 2005;12(2):81-5.
2005: Kennedy R Lees; Matthew R Walters
Acute stroke and diabetes.
Cerebrovascular diseases (Basel, Switzerland) 2005;20 Suppl 1():9-14.
2005: Matthew R Walters; Keith W Muir; Joseph Harbison; Kennedy R Lees; Gary A Ford
Intravenous thrombolysis for acute ischaemic stroke: preliminary experience with recombinant tissue plasminogen activator in the UK.
Cerebrovascular diseases (Basel, Switzerland) 2005;20(6):438-42.
2005: Matthew R Walters; Markku Kaste; Kennedy R Lees; Hans C Diener; Marc Hommel; Jacques De Keyser; Heike Steiner; Mark Versavel
The AMPA antagonist ZK 200775 in patients with acute ischaemic stroke: a double-blind, multicentre, placebo-controlled safety and tolerability study.
Cerebrovascular diseases (Basel, Switzerland) 2005;20(5):304-9.
2005: Siv Jönsson; Yi-Fang Cheng; Charlotte Edenius; Kennedy R Lees; Tomas Odergren; Mats O Karlsson
Population pharmacokinetic modelling and estimation of dosing strategy for NXY-059, a nitrone being developed for stroke.
Clinical pharmacokinetics 2005;44(8):863-78.
2005: Fozia S Nazir; James R Overell; Alison A Bolster; Tom E Hilditch; Kennedy R Lees
Effect of perindopril on cerebral and renal perfusion on normotensives in mild early ischaemic stroke: a randomized controlled trial.
Cerebrovascular diseases (Basel, Switzerland) 2005;19(2):77-83.
2005: Werner Hacke; Greg Albers; Yasir Al-Rawi; daryoush heydari; Antonio Davalos; Michael Eliasziw; Michael Fischer; Anthony Furlan; Markku Kaste; Kennedy R Lees; Mariola Soehngen; Steven Warach
The Desmoteplase in Acute Ischemic Stroke Trial (DIAS): a phase II MRI-based 9-hour window acute stroke thrombolysis trial with intravenous desmoteplase.
Stroke; a journal of cerebral circulation 2005;36(1):66-73.
2004: C A L Bain; Matthew R Walters; Kennedy R Lees; Mary Ann Lumsden
The effect of HRT on cerebral haemodynamics and cerebral vasomotor reactivity in post-menopausal women.
Human reproduction (Oxford, England) 2004;19(10):2411-4.
2004: Christopher J Weir; Markku Kaste; Kennedy R Lees
Targeting neuroprotection clinical trials to ischemic stroke patients with potential to benefit from therapy.
Stroke; a journal of cerebral circulation 2004;35(9):2111-6.
2004: Stella Aslanyan; Christopher J Weir; S Claiborne Johnston; Kennedy R Lees
Poststroke neurological improvement within 7 days is associated with subsequent deterioration.
Stroke; a journal of cerebral circulation 2004;35(9):2165-70.
2004: Matthew Walters; Scott Muir; Imtiaz Shah; Kennedy R Lees
Effect of perindopril on cerebral vasomotor reactivity in patients with lacunar infarction.
Stroke; a journal of cerebral circulation 2004;35(8):1899-902.
2004: Stella Aslanyan; Christopher J Weir; Kennedy R Lees
Elevated pulse pressure during the acute period of ischemic stroke is associated with poor stroke outcome.
Stroke; a journal of cerebral circulation 2004;35(6):e153-5.
2004: Fozia S Nazir; James R Overell; Alison A Bolster; Tom E Hilditch; John L Reid; Kennedy R Lees
The effect of losartan on global and focal cerebral perfusion and on renal function in hypertensives in mild early ischaemic stroke.
Journal of hypertension 2004;22(5):989-95.
2004: Lorraine N Smith; Maggie Lawrence; Susan M Kerr; Peter Langhorne; Kennedy R Lees
Informal carers' experience of caring for stroke survivors.
Journal of advanced nursing 2004;46(3):235-44.
2004: Lorraine N Smith; John Norrie; Susan M Kerr; I Maggie Lawrence; Peter Langhorne; Kennedy R Lees
Impact and influences on caregiver outcomes at one year post-stroke.
Cerebrovascular diseases (Basel, Switzerland) 2004;18(2):145-53.
2004: Kim Bolland; Amanda Weeks; Roshini Sooriyarachchi; Kennedy R Lees
How a sequential design would have affected the GAIN International Study of gavestinel in stroke.
Cerebrovascular diseases (Basel, Switzerland) 2004;17(2-3):111-7.
2004: Stella Aslanyan; Christopher J Weir; Hans-Christoph Diener; M Kaste; Kennedy R Lees
Pneumonia and urinary tract infection after acute ischaemic stroke: a tertiary analysis of the GAIN International trial.
European journal of neurology : the official journal of the European Federation of Neurological Societies 2004;11(1):49-53.
2003: Kennedy R Lees
Stroke is best managed by a neurologist: battle of the titans.
Stroke; a journal of cerebral circulation 2003;34(11):2764-5.
2003: Stella Aslanyan; Christopher J Weir; Kennedy R Lees; John L Reid; Gordon T McInnes
Effect of area-based deprivation on the severity, subtype, and outcome of ischemic stroke.
Stroke; a journal of cerebral circulation 2003;34(11):2623-8.
2003: Michael Krams; Kennedy R Lees; Werner Hacke; Andrew P Grieve; Jean-Marc Orgogozo; Gary A Ford
Acute Stroke Therapy by Inhibition of Neutrophils (ASTIN): an adaptive dose-response study of UK-279,276 in acute ischemic stroke.
Stroke; a journal of cerebral circulation 2003;34(11):2543-8.
2003: Fiona B Young; Kennedy R Lees; Christopher J Weir
Strengthening acute stroke trials through optimal use of disability end points.
Stroke; a journal of cerebral circulation 2003;34(11):2676-80.
2003: Stella Aslanyan; Franz Fazekas; Christopher J Weir; Susanna Horner; Kennedy R Lees
Effect of blood pressure during the acute period of ischemic stroke on stroke outcome: a tertiary analysis of the GAIN International Trial.
Stroke; a journal of cerebral circulation 2003;34(10):2420-5.
2003: Christopher J Weir; Scott Muir; Matthew R Walters; Kennedy R Lees
Serum urate as an independent predictor of poor outcome and future vascular events after acute stroke.
Stroke; a journal of cerebral circulation 2003;34(8):1951-6.
2003: Kennedy R Lees; Hans-Christoph Diener; Kjell Asplund; Michael Krams
UK-279,276, a neutrophil inhibitory glycoprotein, in acute stroke: tolerability and pharmacokinetics.
Stroke; a journal of cerebral circulation 2003;34(7):1704-9.
2003: Christopher J Weir; Kennedy R Lees
Comparison of stratification and adaptive methods for treatment allocation in an acute stroke clinical trial.
Statistics in medicine 2003;22(5):705-26.
2003: Mark O McCarron; Christopher J Weir; Keith W Muir; KL Hoffmann; Carmelo Graffagnino; Nicoll James; Kennedy R Lees; Mark J Alberts
Effect of apolipoprotein E genotype on in-hospital mortality following intracerebral haemorrhage.
Acta neurologica Scandinavica 2003;107(2):106-9.
2003: Kennedy R Lees; David Barer; Gary A Ford; Werner Hacke; V Kostulas; A K Sharma; T Odergren
Tolerability of NXY-059 at higher target concentrations in patients with acute stroke.
Stroke; a journal of cerebral circulation 2003;34(2):482-7.
2003: Kennedy R Lees; Graeme J Hankey; Werner Hacke
Design of future acute-stroke treatment trials.
Lancet neurology 2003;2(1):54-61.
2003: Christopher J Weir; Naveed Sattar; Matthew R Walters; Kennedy R Lees
Low triglyceride, not low cholesterol concentration, independently predicts poor outcome following acute stroke.
Cerebrovascular diseases (Basel, Switzerland) 2003;16(1):76-82.
2003: Kennedy R Lees; Jean-Marc Orgogozo
Acute stroke: trial by jury. The toothless tiger (role of the principal investigator).
European neurology 2003;49(2):120-4.
2003: Kennedy R Lees
Stroke: trial by jury.
European neurology 2003;49(2):106-8.
2002: Jan Willem Elting; Geert Sulter; Markku Kaste; Kennedy R Lees; Hans C Diener; Marc Hommel; Mark Versavel; Albert Teelken; Jacques De Keyser
AMPA antagonist ZK200775 in patients with acute ischemic stroke: possible glial cell toxicity detected by monitoring of S-100B serum levels.
Stroke; a journal of cerebral circulation 2002;33(12):2813-8.
2002: I M Shah; Kennedy R Lees; C P Pien; P J Elliott
Early clinical experience with the novel proteasome inhibitor PS-519.
British journal of clinical pharmacology 2002;54(3):269-76.
2002: Yi Yang; Donald G Grosset; Qiu Li; Ashfaq Shuaib; Kennedy R Lees
Turbulence and circulating cerebral emboli detectable at Doppler ultrasonography: a differentiation study in a stenotic middle cerebral artery model.
AJNR. American journal of neuroradiology 2002;23(7):1229-36.
2002: Farzaneh Harraf; Anil K Sharma; Martin M Brown; Kennedy R Lees; Richard I Vass; Lalit Kalra
A multicentre observational study of presentation and early assessment of acute stroke.
BMJ (Clinical research ed.) 2002;325(7354):17.
2002: Kennedy R Lees
Management of acute stroke.
Lancet neurology 2002;1(1):41-50.
2002: Matthew R Walters; A P J Bradford; J Fischer; Kennedy R Lees
Early clinical experience with the novel NMDA receptor antagonist CNS 5161.
British journal of clinical pharmacology 2002;53(3):305-11.
2002: Kennedy R Lees
Neuroprotection is unlikely to be effective in humans using current trial designs: an opposing view.
Stroke; a journal of cerebral circulation 2002;33(1):308-9.
2001: Christopher J Weir; Mark O McCarron; Keith W Muir; Alexander G Dyker; Ian Bone; Kennedy R Lees; Nicoll James
Apolipoprotein E genotype, coagulation, and survival following acute stroke.
Neurology 2001;57(6):1097-100.
2001: Yi Yang; D G Grosset; Tao Yang; Kennedy R Lees
Characterization of ultrasound-detected cerebral microemboli in patients undergoing cardiac catheterization using an in vitro middle cerebral artery model.
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 2001;53(3):323-30.
2001: Philip Bath; G Boysen; Geoffrey A Donnan; Markku Kaste; Kennedy R Lees; T Olsen; K Overgaard; Peter Sandercock; Nils-Gunnar Wahlgren
Hypertension in acute stroke: what to do?
Stroke; a journal of cerebral circulation 2001;32(7):1697-8.
2001: Matthew R Walters; Kennedy R Lees
Transient ischaemic attacks: a GP guide.
The Practitioner 2001;245(1623):481, 484, 488-91 passim.
2001: JR Overell; Kennedy R Lees; I Bone
Percutaneous closure of patent foramen ovale in patients with paradoxical embolism.
Circulation 2001;103(10):E56.
2001: Kennedy R Lees; A K Sharma; David Barer; Gary A Ford; V Kostulas; Y F Cheng; T Odergren
Tolerability and pharmacokinetics of the nitrone NXY-059 in patients with acute stroke.
Stroke; a journal of cerebral circulation 2001;32(3):675-80.
2001: Matthew R Walters; Alison A Bolster; Alexander G Dyker; Kennedy R Lees
Effect of perindopril on cerebral and renal perfusion in stroke patients with carotid disease.
Stroke; a journal of cerebral circulation 2001;32(2):473-8.
2001: Kennedy R Lees; Alexander G Dyker; A Sharma; Gary A Ford; M E Ardron; Donald G Grosset
Tolerability of the low-affinity, use-dependent NMDA antagonist AR-R15896AR in stroke patients: a dose-ranging study.
Stroke; a journal of cerebral circulation 2001;32(2):466-72.
2001: Kennedy R Lees; J F Lavelle; L Cunha; H C Diener; E A Sanders; P Tack; P Wester
Glycine antagonist (GV150526) in acute stroke: a multicentre, double-blind placebo-controlled phase II trial.
Cerebrovascular diseases (Basel, Switzerland) 2001;11(1):20-9.
2001: Kennedy R Lees
Advances in neuroprotection trials.
European neurology 2001;45(1):6-10.
2000: Keith W Muir; L Holzapfel; Kennedy R Lees
Phase II clinical trial of sipatrigine (619C89) by continuous infusion in acute stroke.
Cerebrovascular diseases (Basel, Switzerland) 2000;10(6):431-6.
2000: JR Overell; I Bone; Kennedy R Lees
Interatrial septal abnormalities and stroke: a meta-analysis of case-control studies.
Neurology 2000;55(8):1172-9.
2000: Kennedy R Lees; Kjell Asplund; Antonio Carolei; S M Davis; Hans-Christoph Diener; M Kaste; Jean-Marc Orgogozo; J Whitehead
Glycine antagonist (gavestinel) in neuroprotection (GAIN International) in patients with acute stroke: a randomised controlled trial. GAIN International Investigators.
Lancet 2000;355(9219):1949-54.
2000: Yi Yang; D G Grosset; Q Li; Kennedy R Lees
Identification of echocardiographic "smoke" in a bench model with transcranial Doppler ultrasound.
Stroke; a journal of cerebral circulation 2000;31(4):907-14.
1999: AG Dyker; K R Edwards; P B Fayad; J T Hormes; Kennedy R Lees
Safety and tolerability study of aptiganel hydrochloride in patients with an acute ischemic stroke.
Stroke; a journal of cerebral circulation 1999;30(10):2038-42.
1999: AG Dyker; Kennedy R Lees
Remacemide hydrochloride: a double-blind, placebo-controlled, safety and tolerability study in patients with acute ischemic stroke.
Stroke; a journal of cerebral circulation 1999;30(9):1796-801.
1999: AG Dyker; Kennedy R Lees
Safety and tolerability of GV150526 (a glycine site antagonist at the N-methyl-D-aspartate receptor) in patients with acute stroke.
Stroke; a journal of cerebral circulation 1999;30(5):986-92.
1999: Keith W Muir; Christopher J Weir; W Alwan; I B Squire; Kennedy R Lees
C-reactive protein and outcome after ischemic stroke.
Stroke; a journal of cerebral circulation 1999;30(5):981-5.
1998: M O MCarron; Keith W Muir; Christopher J Weir; Alexander G Dyker; Ian Bone; Nicoll James; Kennedy R Lees
The apolipoprotein E epsilon4 allele and outcome in cerebrovascular disease.
Stroke; a journal of cerebral circulation 1998;29(9):1882-7.
1998: Werner Hacke; Kennedy R Lees; T Timmerhuis; J Haan; L Hantson; Michael Hennerici; Hans-Christoph Diener
Cardiovascular safety of lubeluzole (Prosynap(R)) in patients with ischemic stroke.
Cerebrovascular diseases (Basel, Switzerland) 1998;8(5):247-54.
1998: L Murray; Iain B Squire; John L Reid; Kennedy R Lees
Determinants of the blood pressure response to the first dose of ACE inhibitor in mild to moderate congestive heart failure.
British journal of clinical pharmacology 1998;45(6):559-66.
1998: Keith W Muir; Kennedy R Lees
Dose optimization of intravenous magnesium sulfate after acute stroke.
Stroke; a journal of cerebral circulation 1998;29(5):918-23.
1998: J A Gratton; A Sauter; M Rudin; Kennedy R Lees; John H McColl; John L Reid; Anna F Dominiczak; I Mhairi Macrae
Susceptibility to cerebral infarction in the stroke-prone spontaneously hypertensive rat is inherited as a dominant trait.
Stroke; a journal of cerebral circulation 1998;29(3):690-4.
1998: Alexander G Dyker; Kennedy R Lees
Duration of neuroprotective treatment for ischemic stroke.
Stroke; a journal of cerebral circulation 1998;29(2):535-42.
1998: Keith W Muir; S J Hamilton; M W Lunnon; S Hobbiger; Kennedy R Lees
Safety and tolerability of 619C89 after acute stroke.
Cerebrovascular diseases (Basel, Switzerland) 1998;8(1):31-7.
1997: Kennedy R Lees
Cerestat and other NMDA antagonists in ischemic stroke.
Neurology 1997;49(5 Suppl 4):S66-9.
1997: Alexander G Dyker; Christopher J Weir; Kennedy R Lees
Influence of cholesterol on survival after stroke: retrospective study.
BMJ (Clinical research ed.) 1997;314(7094):1584-8.
1997: Christopher J Weir; Gordon D Murray; Alexander G Dyker; Kennedy R Lees
Is hyperglycaemia an independent predictor of poor outcome after acute stroke? Results of a long-term follow up study.
BMJ (Clinical research ed.) 1997;314(7090):1303-6.
1997: Alexander G Dyker; Donald G Grosset; Kennedy R Lees
Perindopril reduces blood pressure but not cerebral blood flow in patients with recent cerebral ischemic stroke.
Stroke; a journal of cerebral circulation 1997;28(3):580-3.
1997: Christopher J Weir; Alison A Bolster; S Tytler; Gordon D Murray; R S Corrigall; F G Adams; Kennedy R Lees
Prognostic value of single-photon emission tomography in acute ischaemic stroke.
European journal of nuclear medicine 1997;24(1):21-6.
1996: Alexander G Dyker; Kennedy R Lees
The rationale for new therapies in acute ischaemic stroke.
Journal of clinical pharmacy and therapeutics 1996;21(6):377-91.
1996: Kennedy R Lees; A G Dyker
Blood pressure control after acute stroke.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension 1996;14(6):S35-8.
1996: Keith W Muir; Christopher J Weir; Gordon D Murray; C Povey; Kennedy R Lees
Comparison of neurological scales and scoring systems for acute stroke prognosis.
Stroke; a journal of cerebral circulation 1996;27(10):1817-20.
1996: S K Glen; H L Elliott; J L Curzio; Kennedy R Lees; J L Reid
White-coat hypertension as a cause of cardiovascular dysfunction.
Lancet 1996;348(9028):654-7.
1996: Z Hussein; I J Fraser; Kennedy R Lees; Keith W Muir; M W Lunnon; S F Hobbiger; J Posner
Pharmacokinetics of 619C89, a novel neuronal sodium channel inhibitor, in acute stroke patients after loading and discrete maintenance infusions.
British journal of clinical pharmacology 1996;41(6):505-11.
1996: I B Squire; R J MacFayden; John L Reid; AM Devlin; Kennedy R Lees
Differing early blood pressure and renin-angiotensin system responses to the first dose of angiotensin-converting enzyme inhibitors in congestive heart failure.
Journal of cardiovascular pharmacology 1996;27(5):657-66.
1996: Donald G Grosset; D Georgiadis; andrew william kelman; P Cowburn; S Stirling; Kennedy R Lees; A Faichney; A Mallinson; R Quin; I Bone; L Pettigrew; E Brodie; TG Mackay; D J Wheatley
Detection of microemboli by transcranial Doppler ultrasound.
Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital 1996;23(4):289-92.
1996: D Georgiadis; M Kaps; J Berg; TG Mackay; F Dapper; A Faichney; D J Wheatley; Kennedy R Lees
Transcranial Doppler detection of microemboli in prosthetic heart valve patients: dependency upon valve type.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 1996;10(4):253-7; discussion 257-8.
1995: S Ueda; Christopher J Weir; G C Inglis; Gordon D Murray; Keith W Muir; Kennedy R Lees
Lack of association between angiotensin converting enzyme gene insertion/deletion polymorphism and stroke.
Journal of hypertension 1995;13(12 Pt 2):1597-601.
1995: Kennedy R Lees; Christopher J Weir; G J Gillen; A K Taylor; C Ritchie
Comparison of mean cerebral transit time and single-photon emission tomography for estimation of stroke outcome.
European journal of nuclear medicine 1995;22(11):1261-7.
1995: TG Mackay; D Georgiadis; Donald G Grosset; Kennedy R Lees; David J Wheatley
On the origin of cerebrovascular microemboli associated with prosthetic heart valves.
Neurological research 1995;17(5):349-52.
1995: Kennedy R Lees; Alexander G Dyker; A G Dykes
Diagnosis and therapeutic aspects of stroke.
The Netherlands journal of medicine 1995;47(4):195-8.
1995: AD Morris; C Ritchie; Donald G Grosset; F G Adams; Kennedy R Lees
A pilot study of streptokinase for acute cerebral infarction.
QJM : monthly journal of the Association of Physicians 1995;88(10):727-31.
1995: Keith W Muir; Donald G Grosset; Kennedy R Lees
Clinical pharmacology of CNS 1102 in man.
Annals of the New York Academy of Sciences 1995;765():336-7.
1995: Keith W Muir; Kennedy R Lees; S J Hamilton; C F George; S F Hobbiger; M W Lunnon
A randomized, double-blind, placebo-controlled ascending dose tolerance study of 619C89 in acute stroke.
Annals of the New York Academy of Sciences 1995;765():328-9.
1995: Keith W Muir; Kennedy R Lees
Initial experience with remacemide hydrochloride in patients with acute ischemic stroke.
Annals of the New York Academy of Sciences 1995;765():322-3.
1995: I B Squire; Kennedy R Lees; W Pryse-Phillips; A Kertesz; J Bamford
Efficacy and tolerability of lifarizine in acute ischemic stroke. A pilot study. Lifarizine Study Group.
Annals of the New York Academy of Sciences 1995;765():317-8.
1995: Keith W Muir; Kennedy R Lees
A randomized, double-blind, placebo-controlled pilot trial of intravenous magnesium sulfate in acute stroke.
Annals of the New York Academy of Sciences 1995;765():315-6.
1995: Keith W Muir; Donald G Grosset; Kennedy R Lees
Clinical pharmacology of CNS 1102 in volunteers.
Annals of the New York Academy of Sciences 1995;765():279-89; discussion 298.
1995: TG Mackay; D Georgiadis; Donald G Grosset; andrew william kelman; Kennedy R Lees; David J Wheatley
Transcranial Doppler ultrasound signals associated with prosthetic heart valves: an in vitro study.
The Journal of heart valve disease 1995;4(4):414-9.
1995: Keith W Muir; Kennedy R Lees
A randomized, double-blind, placebo-controlled pilot trial of intravenous magnesium sulfate in acute stroke.
Stroke; a journal of cerebral circulation 1995;26(7):1183-8.
1995: S K Glen; D Georgiadis; Donald G Grosset; J D Douglas; Kennedy R Lees
Transcranial Doppler ultrasound in commercial air divers: a field study including cases with right-to-left shunting.
Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc 1995;22(2):129-35.
1995: J G Houston; AD Morris; Donald G Grosset; Kennedy R Lees; N McMillan; I Bone
Ultrasonic evaluation of movement of the diaphragm after acute cerebral infarction.
Journal of neurology, neurosurgery, and psychiatry 1995;58(6):738-41.
1995: Donald G Grosset; Keith W Muir; Kennedy R Lees
Systemic and cerebral hemodynamic responses to the noncompetitive N-methyl-D-aspartate (NMDA) antagonist CNS 1102.
Journal of cardiovascular pharmacology 1995;25(5):705-9.
1995: Keith W Muir; Kennedy R Lees
Clinical experience with excitatory amino acid antagonist drugs.
Stroke; a journal of cerebral circulation 1995;26(3):503-13.
1994: P E Bannan; D I Graham; Kennedy R Lees; James McCulloch
Neuroprotective effect of remacemide hydrochloride in focal cerebral ischemia in the cat.
Brain research 1994;664(1-2):271-5.
1994: Christopher J Weir; Gordon D Murray; F G Adams; Keith W Muir; Donald G Grosset; Kennedy R Lees
Poor accuracy of stroke scoring systems for differential clinical diagnosis of intracranial haemorrhage and infarction.
Lancet 1994;344(8928):999-1002.
1994: R J MacFadyen; Kennedy R Lees; John L Reid
Responses to low dose intravenous perindoprilat infusion in salt deplete/salt replete normotensive volunteers.
British journal of clinical pharmacology 1994;38(4):329-34.
1994: Donald G Grosset; D Georgiadis; P Cowburn; Kennedy R Lees
Transcranial Doppler for emboli.
Neurology 1994;44(10):1980-1.
1994: Keith W Muir; I B Squire; W Alwan; Kennedy R Lees
Anticardiolipin antibodies in an unselected stroke population.
Lancet 1994;344(8920):452-6.
1994: I B Squire; R J Macfadyen; Kennedy R Lees; W Stewart Hillis; John L Reid
Haemodynamic response and pharmacokinetics after the first dose of quinapril in patients with congestive heart failure.
British journal of clinical pharmacology 1994;38(2):117-23.
1994: D Georgiadis; TG Mackay; andrew william kelman; Donald G Grosset; David J Wheatley; Kennedy R Lees
Differentiation between gaseous and formed embolic materials in vivo. Application in prosthetic heart valve patients.
Stroke; a journal of cerebral circulation 1994;25(8):1559-63.
1994: Keith W Muir; Donald G Grosset; Kennedy R Lees
Interconversion of stroke scales. Implications for therapeutic trials.
Stroke; a journal of cerebral circulation 1994;25(7):1366-70.
1994: Keith W Muir; Donald G Grosset; E Gamzu; Kennedy R Lees
Pharmacological effects of the non-competitive NMDA antagonist CNS 1102 in normal volunteers.
British journal of clinical pharmacology 1994;38(1):33-8.
1994: D Georgiadis; A Mallinson; Donald G Grosset; Kennedy R Lees
Coagulation activity and emboli counts in patients with prosthetic cardiac valves.
Stroke; a journal of cerebral circulation 1994;25(6):1211-4.
1994: D Georgiadis; Donald G Grosset; R O Quin; J A Nichol; I Bone; Kennedy R Lees
Detection of intracranial emboli in patients with carotid disease.
European journal of vascular surgery 1994;8(3):309-14.
1994: D Georgiadis; Donald G Grosset; A Kelman; A Faichney; Kennedy R Lees
Prevalence and characteristics of intracranial microemboli signals in patients with different types of prosthetic cardiac valves.
Stroke; a journal of cerebral circulation 1994;25(3):587-92.
1994: Donald G Grosset; D Georgiadis; I Abdullah; I Bone; Kennedy R Lees
Doppler emboli signals vary according to stroke subtype.
Stroke; a journal of cerebral circulation 1994;25(2):382-4.
1994: Donald G Grosset; D Georgiadis; S Stirling; P Cowburn; andrew william kelman; A Faichney; Kennedy R Lees
Subclinical embolism in patients undergoing cardiac valve implantation and coronary artery bypass surgery.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 1994;8(2):63-6; discussion 66.
1993: Donald G Grosset; I B Squire; D Georgiadis; Kennedy R Lees
Repeatability testing for transcranial Doppler sonography.
Clinical science (London, England : 1979) 1993;85(6):761-2.
1993: D Georgiadis; Donald G Grosset; Kennedy R Lees
Transhemispheric passage of microemboli in patients with unilateral internal carotid artery occlusion.
Stroke; a journal of cerebral circulation 1993;24(11):1664-6.
1993: A D Bainbridge; R J Macfadyen; S Stark; Kennedy R Lees; John L Reid
The antihypertensive efficacy and tolerability of a low dose combination of ramipril and felodipine ER in mild to moderate essential hypertension.
British journal of clinical pharmacology 1993;36(4):323-30.
1993: John L Reid; R J MacFadyen; I B Squire; Kennedy R Lees
Angiotensin-converting enzyme inhibitors in heart failure: blood pressure changes after the first dose.
American heart journal 1993;126(3 Pt 2):794-7.
1993: Kennedy R Lees; R J MacFadyen; J K Doig; John L Reid
Role of angiotensin in the extravascular system.
Journal of human hypertension 1993;7 Suppl 2():S7-12.
1993: John L Reid; R J MacFadyen; I B Squire; Kennedy R Lees
Blood pressure response to the first dose of angiotensin-converting enzyme inhibitors in congestive heart failure.
The American journal of cardiology 1993;71(17):57E-60E.
1993: J K Doig; R J MacFadyen; C S Sweet; Kennedy R Lees; John L Reid
Dose-ranging study of the angiotensin type I receptor antagonist losartan (DuP753/MK954), in salt-deplete normal man.
Journal of cardiovascular pharmacology 1993;21(5):732-8.
1993: AD Morris; Donald G Grosset; I B Squire; Kennedy R Lees; I Bone; John L Reid
The experiences of an acute stroke unit--implications for multicentre acute stroke trials.
Journal of neurology, neurosurgery, and psychiatry 1993;56(4):352-5.
1993: R J MacFadyen; Kennedy R Lees; John L Reid
Double blind controlled study of low dose intravenous perindoprilat or enalaprilat infusion in elderly patients with heart failure.
British heart journal 1993;69(4):293-7.
1992: Kennedy R Lees
Therapeutic interventions in acute stroke.
British journal of clinical pharmacology 1992;34(6):486-93.
1992: I Squire; Kennedy R Lees
Using controlled-release preparations.
The Practitioner 1992;236(1521):1160-3.
1992: I Squire; Kennedy R Lees
Slow-release delivery systems.
The Practitioner 1992;236(1520):1088-91.
1992: R J MacFadyen; Kennedy R Lees; John L Reid
Studies with low dose intravenous diacid ACE inhibitor (perindoprilat) infusions in normotensive male volunteers.
British journal of clinical pharmacology 1992;34(2):115-21.
1992: Kennedy R Lees
The dose-response relationship with angiotensin converting enzyme inhibitors: effects on blood pressure and biochemical parameters.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension 1992;10(5):S3-11.
1992: I Squire; Kennedy R Lees
Topical drug delivery.
The Practitioner 1992;236(1511):203-6.
1992: Kennedy R Lees; I B Squire; John L Reid
The clinical pharmacology of ACE inhibitors: evidence for clinically relevant differences?
Clinical and experimental pharmacology & physiology. Supplement 1992;19():49-53.
1991: R J MacFadyen; Kennedy R Lees; John L Reid
Blood pressure responses to low-dose oral ester or intravenous diacid angiotensin converting enzyme inhibitors.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension 1991;9(6):S376-7.
1991: R J MacFadyen; A D Bainbridge; Kennedy R Lees; John L Reid
The response to the first dose of an angiotensin converting enzyme inhibitor in uncomplicated hypertension--a placebo controlled study utilising ambulatory blood pressure recording.
British journal of clinical pharmacology 1991;32(3):393-8.
1991: R J MacFadyen; Kennedy R Lees; John L Reid
Differences in first dose response to angiotensin converting enzyme inhibition in congestive heart failure: a placebo controlled study.
British heart journal 1991;66(3):206-11.
1991: R J MacFadyen; Kennedy R Lees; J D Gemmill; W Stewart Hillis; John L Reid
Transpulmonary pharmacokinetics of an ACE inhibitor (perindoprilat) in man.
British journal of clinical pharmacology 1991;32(2):193-9.
1991: A D Bainbridge; R J MacFadyen; Kennedy R Lees; John L Reid
A study of the acute pharmacodynamic interaction of ramipril and felodipine in normotensive subjects.
British journal of clinical pharmacology 1991;31(2):148-53.
1991: R J MacFadyen; Kennedy R Lees; John L Reid
Tissue and plasma angiotensin converting enzyme and the response to ACE inhibitor drugs.
British journal of clinical pharmacology 1991;31(1):1-13.
1990: Kennedy R Lees
Clinical pharmacology of perindopril.
Journal of human hypertension 1990;4 Suppl 4():7-8; discussion 9-11.
1990: N J MacDonald; D M Hughes; Kennedy R Lees; John L Reid
Pharmacodynamic, pharmacokinetic and humoral effects of oral zabicipril, an angiotensin converting enzyme inhibitor in normotensive man.
British journal of clinical pharmacology 1990;30(1):107-13.
1989: Karen Hogg; Kennedy R Lees; R S Hornung; C A Howie; Francis G Dunn; W Stewart Hillis
Electrocardiographic evidence of myocardial salvage after thrombolysis in acute myocardial infarction.
British heart journal 1989;61(6):489-95.
1989: John L Reid; N J Macdonald; Kennedy R Lees; H L Elliott
Angiotensin-converting enzyme inhibitors in the elderly.
American heart journal 1989;117(3):751-5.