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Mathew Leese

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Fabrice Jourdan; Mathew P Leese; Simon P Newman; Surinder Chander; Wolfgang Dohle; Eric Ferrandis; Atul Purohit; Barry V L Potter
Structure-activity relationships of C-17-substituted estratriene-3-O-sulfamates as anticancer agents.
Mathew P Leese; Fabrice Jourdan; Meriel R Kimberley; Gyles E Cozier; Nethaji Thiyagarajan; Chloe Stengel; Sandra Regis-Lydi; Paul A Foster; Simon P Newman; K Ravi Acharya; Eric Ferrandis; Atul Purohit; Michael J Reed; Barry V L Potter
Chimeric microtubule disruptors.
Gyles E Cozier; Mathew P Leese; Matthew D Lloyd; Matthew D Baker; Nethaji Thiyagarajan; K Ravi Acharya; Barry V L Potter
Structures of human carbonic anhydrase II/inhibitor complexes reveal a second binding site for steroidal and nonsteroidal inhibitors.

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All Publications

2011: Fabrice Jourdan; Mathew P Leese; Simon P Newman; Surinder Chander; Wolfgang Dohle; Eric Ferrandis; Atul Purohit; Barry V L Potter
Structure-activity relationships of C-17-substituted estratriene-3-O-sulfamates as anticancer agents.
Journal of medicinal chemistry 2011;54(13):4863-79.
2010: Mathew P Leese; Fabrice Jourdan; Meriel R Kimberley; Gyles E Cozier; Nethaji Thiyagarajan; Chloe Stengel; Sandra Regis-Lydi; Paul A Foster; Simon P Newman; K Ravi Acharya; Eric Ferrandis; Atul Purohit; Michael J Reed; Barry V L Potter
Chimeric microtubule disruptors.
Chemical communications (Cambridge, England) 2010;46(17):2907-9.
2010: Gyles E Cozier; Mathew P Leese; Matthew D Lloyd; Matthew D Baker; Nethaji Thiyagarajan; K Ravi Acharya; Barry V L Potter
Structures of human carbonic anhydrase II/inhibitor complexes reveal a second binding site for steroidal and nonsteroidal inhibitors.
Biochemistry 2010;49(16):3464-76.
2010: Fabrice Jourdan; Mathew P Leese; Wolfgang Dohle; Ernest Hamel; Eric Ferrandis; Simon P Newman; Atul Purohit; Michael J Reed; Barry V L Potter
Synthesis, antitubulin, and antiproliferative SAR of analogues of 2-methoxyestradiol-3,17-O,O-bis-sulfamate.
Journal of medicinal chemistry 2010;53(7):2942-51.
2008: Fabrice Jourdan; Christian Bubert; Mathew P Leese; Andrew Smith; Eric Ferrandis; Sandra Regis-Lydi; Simon P Newman; Atul Purohit; Michael J Reed; Barry V L Potter
Effects of C-17 heterocyclic substituents on the anticancer activity of 2-ethylestra-1,3,5(10)-triene-3-O-sulfamates: synthesis, in vitro evaluation and computational modelling.
Organic & biomolecular chemistry 2008;6(22):4108-19.
2008: M F C Parsons; Paul A Foster; Surinder K Chander; R Jhalli; Simon P Newman; Mathew P Leese; Barry V L Potter; Atul Purohit; Michael J Reed
The in vivo properties of STX243: a potent angiogenesis inhibitor in breast cancer.
British journal of cancer 2008;99(9):1433-41.
2008: Paul A Foster; Yaik T Ho; Simon P Newman; Philip G Kasprzyk; Mathew P Leese; Barry V L Potter; Michael J Reed; Atul Purohit
2-MeOE2bisMATE and 2-EtE2bisMATE induce cell cycle arrest and apoptosis in breast cancer xenografts as shown by a novel ex vivo technique.
Breast cancer research and treatment 2008;111(2):251-60.
2008: Paul A Foster; C Stengel; Tauhid Ali; Mathew P Leese; Barry V L Potter; Michael J Reed; Atul Purohit; Simon P Newman
A comparison of two orally bioavailable anti-cancer agents, IRC-110160 and STX140.
Anticancer research 2008;28(3A):1483-91.
2008: Mathew P Leese; Fabrice L Jourdan; Keira Gaukroger; Mary F Mahon; Simon P Newman; Paul A Foster; Chloe Stengel; Sandra Regis-Lydi; Eric Ferrandis; Anna Di Fiore; Giuseppina De simone; Claudiu T Supuran; Atul Purohit; Michael J Reed; Barry V L Potter
Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents.
Journal of medicinal chemistry 2008;51(5):1295-308.
2008: Paul A Foster; Simon P Newman; Mathew P Leese; Sonia Bernetiere; Christian Diolez; Jose CAMARA; Beatrice Hacher; Marie-Madeleine Baronnet; Tauhid Ali; Barry V L Potter; Michael J Reed; Atul Purohit
A new micronized formulation of 2-methoxyestradiol-bis-sulfamate (STX140) is therapeutically potent against breast cancer.
Anticancer research 2008;28(2A):577-81.
2008: Simon P Newman; Paul A Foster; Chloe Stengel; Joanna M Day; Yaik T Ho; Jean-Gabriel Judde; Myriam Lassalle; Gregoire Prevost; Mathew P Leese; Barry V L Potter; Michael J Reed; Atul Purohit
STX140 is efficacious in vitro and in vivo in taxane-resistant breast carcinoma cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(2):597-606.
2007: Simon P Newman; Paul A Foster; Yaik T Ho; Joanna M Day; Bindumalini Raobaikady; Philip G Kasprzyk; Mathew P Leese; Barry V L Potter; Michael J Reed; Atul Purohit
The therapeutic potential of a series of orally bioavailable anti-angiogenic microtubule disruptors as therapy for hormone-independent prostate and breast cancers.
British journal of cancer 2007;97(12):1673-82.
2007: Christian Bubert; Mathew P Leese; Mary F Mahon; Eric Ferrandis; Sandra Regis-Lydi; Philip G Kasprzyk; Simon P Newman; Yaik T Ho; Atul Purohit; Michael J Reed; Barry V L Potter
3,17-disubstituted 2-alkylestra-1,3,5(10)-trien-3-ol derivatives: synthesis, in vitro and in vivo anticancer activity.
Journal of medicinal chemistry 2007;50(18):4431-43.
2007: Surinder K Chander; Paul A Foster; Mathew P Leese; Simon P Newman; Barry V L Potter; Atul Purohit; Michael J Reed
In vivo inhibition of angiogenesis by sulphamoylated derivatives of 2-methoxyoestradiol.
British journal of cancer 2007;96(9):1368-76.
2006: Mathew P Leese; Bertrand Leblond; Andrew Smith; Simon P Newman; Anna Di Fiore; Giuseppina De simone; Claudiu T Supuran; Atul Purohit; Michael J Reed; Barry V L Potter
2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity.
Journal of medicinal chemistry 2006;49(26):7683-96.
2006: Simon P Newman; Christopher R Ireson; Helena Tutill; Joanna M Day; Michael F C Parsons; Mathew P Leese; Barry V L Potter; Michael J Reed; Atul Purohit
The role of 17beta-hydroxysteroid dehydrogenases in modulating the activity of 2-methoxyestradiol in breast cancer cells.
Cancer research 2006;66(1):324-30.
2005: Bindumalini Raobaikady; Michael J Reed; Mathew P Leese; Barry V L Potter; Atul Purohit
Inhibition of MDA-MB-231 cell cycle progression and cell proliferation by C-2-substituted oestradiol mono- and bis-3-O-sulphamates.
International journal of cancer. Journal international du cancer 2005;117(1):150-9.
2005: Mathew P Leese; Hatem A M Hejaz; Mary F Mahon; Simon P Newman; Atul Purohit; Michael J Reed; Barry V L Potter
A-ring-substituted estrogen-3-O-sulfamates: potent multitargeted anticancer agents.
Journal of medicinal chemistry 2005;48(16):5243-56.
2005: Mathew P Leese; Bertrand Leblond; Simon P Newman; Atul Purohit; Michael J Reed; Barry V L Potter
Anti-cancer activities of novel D-ring modified 2-substituted estrogen-3-O-sulfamates.
The Journal of steroid biochemistry and molecular biology 2005;94(1-3):239-51.
2005: T Utsumi; Mathew P Leese; Surinder K Chander; K Gaukroger; Atul Purohit; Simon P Newman; Barry V L Potter; Michael J Reed
The effects of 2-methoxyoestrogen sulphamates on the in vitro and in vivo proliferation of breast cancer cells.
The Journal of steroid biochemistry and molecular biology 2005;94(1-3):219-27.
2005: Atul Purohit; Margaret W Ghilchik; Mathew P Leese; Barry V L Potter; Michael J Reed
Regulation of aromatase activity by cytokines, PGE2 and 2-methoxyoestrone-3-O-sulphamate in fibroblasts derived from normal and malignant breast tissues.
The Journal of steroid biochemistry and molecular biology 2005;94(1-3):167-72.
2004: Mathew P Leese; Simon P Newman; Atul Purohit; Michael J Reed; Barry V L Potter
2-Alkylsulfanyl estrogen derivatives: synthesis of a novel class of multi-targeted anti-tumour agents.
Bioorganic & medicinal chemistry letters 2004;14(12):3135-8.
2004: Julie E Reed; L W Lawrence Woo; James J Robinson; Bertrand Leblond; Mathew P Leese; Atul Purohit; Michael J Reed; Barry V L Potter
2-difluoromethyloestrone 3-O-sulphamate, a highly potent steroid sulphatase inhibitor.
Biochemical and biophysical research communications 2004;317(1):169-75.
2004: Simon P Newman; Mathew P Leese; Atul Purohit; David R C James; Catherine E Rennie; Barry V L Potter; Michael J Reed
Inhibition of in vitro angiogenesis by 2-methoxy- and 2-ethyl-estrogen sulfamates.
International journal of cancer. Journal international du cancer 2004;109(4):533-40.
2004: Christopher R Ireson; Surinder K Chander; Atul Purohit; S Perera; Simon P Newman; David C Parish; Mathew P Leese; A C Smith; Barry V L Potter; Michael J Reed
Pharmacokinetics and efficacy of 2-methoxyoestradiol and 2-methoxyoestradiol-bis-sulphamate in vivo in rodents.
British journal of cancer 2004;90(4):932-7.
2003: Atul Purohit; L W Lawrence Woo; Surinder K Chander; Simon P Newman; Christopher R Ireson; Y Ho; A Grasso; Mathew P Leese; Barry V L Potter; Michael J Reed
Steroid sulphatase inhibitors for breast cancer therapy.
The Journal of steroid biochemistry and molecular biology 2003;86(3-5):423-32.
2003: Yaik T Ho; Simon P Newman; Atul Purohit; Mathew P Leese; Barry V L Potter; Michael J Reed
The effects of 2-methoxy oestrogens and their sulphamoylated derivatives in conjunction with TNF-alpha on endothelial and fibroblast cell growth, morphology and apoptosis.
The Journal of steroid biochemistry and molecular biology 2003;86(2):189-96.
2003: Yaik T Ho; Atul Purohit; Nigel Vicker; Simon P Newman; James J Robinson; Mathew P Leese; Dharshini Ganeshapillai; L W Lawrence Woo; Barry V L Potter; Michael J Reed
Inhibition of carbonic anhydrase II by steroidal and non-steroidal sulphamates.
Biochemical and biophysical research communications 2003;305(4):909-14.
2003: Bindumalini Raobaikady; Atul Purohit; Surinder K Chander; L W Lawrence Woo; Mathew P Leese; Barry V L Potter; Michael J Reed
Inhibition of MCF-7 breast cancer cell proliferation and in vivo steroid sulphatase activity by 2-methoxyoestradiol-bis-sulphamate.
The Journal of steroid biochemistry and molecular biology 2003;84(2-3):351-8.
2003: Joanna M Day; Simon P Newman; Alexander Comninos; Claire Solomon; Atul Purohit; Mathew P Leese; Barry V L Potter; Michael J Reed
The effects of 2-substituted oestrogen sulphamates on the growth of prostate and ovarian cancer cells.
The Journal of steroid biochemistry and molecular biology 2003;84(2-3):317-25.
2003: R N Suzuki; Simon P Newman; Atul Purohit; Mathew P Leese; Barry V L Potter; Michael J Reed
Growth inhibition of multi-drug-resistant breast cancer cells by 2-methoxyoestradiol-bis-sulphamate and 2-ethyloestradiol-bis-sulphamate.
The Journal of steroid biochemistry and molecular biology 2003;84(2-3):269-78.