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Christiaan Leeuwenburgh

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Quinn E Fletcher; Stan Boutin; Christiaan Leeuwenburgh; Andrew G McAdam; Colin Selman; Arnold Y Seo; John R Speakman; Sarah B Woods; Murray M Humphries
Oxidative damage increases with reproductive energy expenditure and is reduced by food-supplementation.
Paul M Coen; Kevin E Conley; Steven R Cummings; Giovanna Distefano; Luigi Ferrucci; Nancy W Glynn; Francesca Amati; Sharon A Jubrias; Christiaan Leeuwenburgh; Dawn C Mackey; Todd M Manini; Anne B Newman; Eric Shankland; Frederico G S Toledo; Stephanie E Wohlgemuth; Bret H Goodpaster
Skeletal muscle mitochondrial energetics are associated with maximal aerobic capacity and walking speed in older adults.
Debapriya Dutta; Jae-Sung Kim; William A Dunn; Jinze Xu; Christiaan Leeuwenburgh
Upregulated autophagy protects cardiomyocytes from oxidative stress-induced toxicity.

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2013: Quinn E Fletcher; Stan Boutin; Christiaan Leeuwenburgh; Andrew G McAdam; Colin Selman; Arnold Y Seo; John R Speakman; Sarah B Woods; Murray M Humphries
Oxidative damage increases with reproductive energy expenditure and is reduced by food-supplementation.
Evolution; international journal of organic evolution 2013;67(5):1527-36.
2013: Paul M Coen; Kevin E Conley; Steven R Cummings; Giovanna Distefano; Luigi Ferrucci; Nancy W Glynn; Francesca Amati; Sharon A Jubrias; Christiaan Leeuwenburgh; Dawn C Mackey; Todd M Manini; Anne B Newman; Eric Shankland; Frederico G S Toledo; Stephanie E Wohlgemuth; Bret H Goodpaster
Skeletal muscle mitochondrial energetics are associated with maximal aerobic capacity and walking speed in older adults.
The journals of gerontology. Series A, Biological sciences and medical sciences 2013;68(4):447-55.
2013: Debapriya Dutta; Jae-Sung Kim; William A Dunn; Jinze Xu; Christiaan Leeuwenburgh
Upregulated autophagy protects cardiomyocytes from oxidative stress-induced toxicity.
Autophagy 2013;9(3):328-44.
2013: Riccardo Calvani; Anna-Maria Joseph; Christiaan Leeuwenburgh; Peter J Adhihetty; Roberto Bernabei; Maurizio Bossola; Alfredo Miccheli; Emanuele Marzetti
Mitochondrial pathways in sarcopenia of aging and disuse muscle atrophy.
Biological chemistry 2013;394(3):393-414.
2012: Anna-Maria Joseph; Hazel A Lees; Peter J Adhihetty; Juan M Aranda; Thomas W Buford; Todd M Manini; Emanuele Marzetti; Linda M-D Nguyen; Marco Pahor; Bhanu D Sandesara; Stephanie E Wohlgemuth; Christiaan Leeuwenburgh
The impact of aging on mitochondrial function and biogenesis pathways in skeletal muscle of sedentary high- and low-functioning elderly individuals.
Aging cell 2012;11(5):801-9.
2012: Debapriya Dutta; Christiaan Leeuwenburgh; Roberto Bernabei; Riccardo Calvani; Emanuele Marzetti
Contribution of impaired mitochondrial autophagy to cardiac aging: mechanisms and therapeutic opportunities.
Circulation research 2012;110(8):1125-38.
2012: Jinze Xu; Zhenhua Jia; Mitchell D Knutson; Christiaan Leeuwenburgh
Impaired iron status in aging research.
International journal of molecular sciences 2012;13(2):2368-86.
2012: Emanuele Marzetti; Marco Pahor; Krista Vandenborne; Juan M Aranda; Roberto Bernabei; Thomas W Buford; Riccardo Calvani; Giorgio Capuani; Hazel A Lees; Christiaan Leeuwenburgh; Donovan J Lott; Todd M Manini; Michael Marsiske; Stephanie E Wohlgemuth
Skeletal muscle apoptotic signaling predicts thigh muscle volume and gait speed in community-dwelling older persons: an exploratory study.
PloS one 2012;7(2):e32829.
2012: Kimberly T Sibille; Roland Staud; Laurence A Bradley; Ben Burkley; Toni L Glover; Yan Gong; Chris King; Taimour Langaee; Christiaan Leeuwenburgh; Joseph L Riley; Roger B Fillingim
Chronic pain, perceived stress, and cellular aging: an exploratory study.
Molecular pain 2012;8():12.
2012: Jin-Hee Wang; Christiaan Leeuwenburgh; Kevin E Behrns; Jae-Sung Kim
Critical role of autophage in ischemia/reperfusion injury to aged livers.
Autophagy 2012;8(1):140-1.
2012: John P Aris; Laura K Fishwick; Christiaan Leeuwenburgh; Michelle L Marraffini; Arnold Y Seo; William A Dunn
Amino Acid Homeostasis and Chronological Longevity in Saccharomyces cerevisiae.
Sub-cellular biochemistry 2012;57():161-86.
2012: Emanuele Marzetti; Roberto Bernabei; Riccardo Calvani; Christiaan Leeuwenburgh
Apoptosis in skeletal myocytes: a potential target for interventions against sarcopenia and physical frailty - a mini-review.
Gerontology 2012;58(2):99-106.
2012: Christy S Carter; Thomas C Foster; Leanne Groban; Christiaan Leeuwenburgh; Todd M Manini; Emanuele Marzetti; Philip J Scarpace; Drake Morgan
Usefulness of preclinical models for assessing the efficacy of late-life interventions for sarcopenia.
The journals of gerontology. Series A, Biological sciences and medical sciences 2012;67(1):17-27.
2011: Jin-Hee Wang; Christiaan Leeuwenburgh; In-Sook Ahn; Kevin E Behrns; Jae-Il Byeon; William A Dunn; Trevan D Fischer; Jae-Sung Kim
Autophagy suppresses age-dependent ischemia and reperfusion injury in livers of mice.
Gastroenterology 2011;141(6):2188-2199.e6.
2011: Stephen D Anton; Jonathan Shuster; Christiaan Leeuwenburgh
Investigations of botanicals on food intake, satiety, weight loss and oxidative stress: study protocol of a double-blind, placebo-controlled, crossover study.
Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 2011;9(11):1190-8.
2011: Adam Gesing; Anna-Maria Joseph; Malgorzata Karbownik-Lewinska; Christiaan Leeuwenburgh; Andrzej Lewinski; Michal Masternak; Feiya Wang; Reyhan Westbrook; Andrzej Bartke
Expression of key regulators of mitochondrial biogenesis in growth hormone receptor knockout (GHRKO) mice is enhanced but is not further improved by other potential life-extending interventions.
The journals of gerontology. Series A, Biological sciences and medical sciences 2011;66(10):1062-76.
2011: Ji Min Kim; Hyoung-Sam Heo; Yeon Ja Choi; Byeong Hyeok Ye; Young Mi Ha; Arnold Y Seo; Byung Pal Yu; Christiaan Leeuwenburgh; Hae Young Chung; Christy S Carter
Inhibition of NF-κB-induced inflammatory responses by angiotensin II antagonists in aged rat kidney.
Experimental gerontology 2011;46(7):542-8.
2011: Joe Nocera; Marco Pahor; Michael G Perri; Thomas W Buford; Christiaan Leeuwenburgh; Todd M Manini; Kelly Naugle; Stephen D Anton
The impact of behavioral intervention on obesity mediated declines in mobility function: implications for longevity.
Journal of aging research 2011;2011():392510.
2010: Benjamin Predmore; Maikel J Alendy; Khadija I Ahmed; Christiaan Leeuwenburgh; David Julian
The hydrogen sulfide signaling system: changes during aging and the benefits of caloric restriction.
Age (Dordrecht, Netherlands) 2010;32(4):467-81.
2010: Shinichi Someya; Wei Yu; William C Hallows; Jinze Xu; James M Vann; Christiaan Leeuwenburgh; Masaru Tanokura; John M Denu; Tomas A Prolla
Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction.
Cell 2010;143(5):802-12.
2010: Thomas W Buford; Stephen D Anton; Andrew R Judge; Emanuele Marzetti; Stephanie E Wohlgemuth; Christy S Carter; Christiaan Leeuwenburgh; Marco Pahor; Todd M Manini
Models of accelerated sarcopenia: critical pieces for solving the puzzle of age-related muscle atrophy.
Ageing research reviews 2010;9(4):369-83.
2010: Arnold Y Seo; Anna-Maria Joseph; Debapriya Dutta; Judy C Y Hwang; John P Aris; Christiaan Leeuwenburgh
New insights into the role of mitochondria in aging: mitochondrial dynamics and more.
Journal of cell science 2010;123(Pt 15):2533-42.
2010: Jinze Xu; Emanuele Marzetti; Arnold Y Seo; Jae-Sung Kim; Tomas A Prolla; Christiaan Leeuwenburgh
The emerging role of iron dyshomeostasis in the mitochondrial decay of aging.
Mechanisms of ageing and development 2010;131(7-8):487-93.
2010: Silvia Giovannini; M Cesari; Emanuele Marzetti; Christiaan Leeuwenburgh; M Maggio; Matteo Cesari
Effects of ACE-inhibition on IGF-1 and IGFBP-3 concentrations in older adults with high cardiovascular risk profile.
The journal of nutrition, health & aging 2010;14(6):457-60.
2010: Thomas W Buford; Matthew B Cooke; Todd M Manini; Christiaan Leeuwenburgh; Darryn S Willoughby
Effects of age and sedentary lifestyle on skeletal muscle NF-kappaB signaling in men.
The journals of gerontology. Series A, Biological sciences and medical sciences 2010;65(5):532-7.
2010: Silvia Giovannini; Graziano Onder; Christiaan Leeuwenburgh; Christy Carter; Emanuele Marzetti; Andrea Russo; Ettore Capoluongo; Marco Pahor; Roberto Bernabei; Francesco Landi
Myeloperoxidase levels and mortality in frail community-living elderly individuals.
The journals of gerontology. Series A, Biological sciences and medical sciences 2010;65(4):369-76.
2010: Emanuele Marzetti; Judy C Y Hwang; Hazel A Lees; Stephanie E Wohlgemuth; Esther E Dupont-Versteegden; Christy S Carter; Roberto Bernabei; Christiaan Leeuwenburgh
Mitochondrial death effectors: relevance to sarcopenia and disuse muscle atrophy.
Biochimica et biophysica acta 2010;1800(3):235-44.
2010: Joanna Joyner-Matos; Benjamin Predmore; Jenny R Stein; Christiaan Leeuwenburgh; David Julian
Hydrogen sulfide induces oxidative damage to RNA and DNA in a sulfide-tolerant marine invertebrate.
Physiological and biochemical zoology : PBZ 2010;83(2):356-65.
2010: Katherine Opalach; Sunitha Rangaraju; Irina Madorsky; Christiaan Leeuwenburgh; Lucia Notterpek
Lifelong calorie restriction alleviates age-related oxidative damage in peripheral nerves.
Rejuvenation research 2010;13(1):65-74.
2010: Stephanie E Wohlgemuth; Arnold Y Seo; Emanuele Marzetti; Hazel Anne Lees; Christiaan Leeuwenburgh
Skeletal muscle autophagy and apoptosis during aging: effects of calorie restriction and life-long exercise.
Experimental gerontology 2010;45(2):138-48.
2010: Asimina Hiona; Alberto Sanz; Gregory C Kujoth; Reinald Pamplona; Arnold Y Seo; Tim Hofer; Shinichi Someya; Takuya Miyakawa; Chie Nakayama; Alejandro K Samhan-Arias; Stephane Servais; Jamie L Barger; Manuel Portero-Otín; Masaru Tanokura; Tomas A Prolla; Christiaan Leeuwenburgh
Mitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator mice.
PloS one 2010;5(7):e11468.
2010: Jinze Xu; Arnold Y Seo; Darya A Vorobyeva; Christy S Carter; Stephen D Anton; A M S Lezza; Christiaan Leeuwenburgh
Beneficial effects of a Q-ter based nutritional mixture on functional performance, mitochondrial function, and oxidative stress in rats.
PloS one 2010;5(5):e10572.
2010: Emanuele Marzetti; Giuseppe Privitera; Vincenzo Simili; Stephanie E Wohlgemuth; Lorenzo Aulisa; Marco Pahor; Christiaan Leeuwenburgh
Multiple pathways to the same end: mechanisms of myonuclear apoptosis in sarcopenia of aging.
TheScientificWorldJournal 2010;10():340-9.
2009: Shinichi Someya; Jinze Xu; Kenji Kondo; Dalian Ding; Richard J Salvi; Tatsuya Yamasoba; Peter S Rabinovitch; Richard Weindruch; Christiaan Leeuwenburgh; Masaru Tanokura; Tomas A Prolla
Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(46):19432-7.
2009: Emanuele Marzetti; Stephanie E Wohlgemuth; Stephen D Anton; Roberto Bernabei; Christy S Carter; Christiaan Leeuwenburgh
Cellular mechanisms of cardioprotection by calorie restriction: state of the science and future perspectives.
Clinics in geriatric medicine 2009;25(4):715-32, ix.
2009: Christy S Carter; Christiaan Leeuwenburgh; Michael Daniels; Thomas C Foster
Influence of calorie restriction on measures of age-related cognitive decline: role of increased physical activity.
The journals of gerontology. Series A, Biological sciences and medical sciences 2009;64(8):850-9.
2009: Ji Young Kim; Dae Hyun Kim; Jaehun Choi; Jin-Kyu Park; Kyu-Shik Jeong; Christiaan Leeuwenburgh; Byung Pal Yu; Hae Young Chung
Changes in lipid distribution during aging and its modulation by calorie restriction.
Age (Dordrecht, Netherlands) 2009;31(2):127-42.
2009: Li Cui; Tim Hofer; Asha Rani; Christiaan Leeuwenburgh; Thomas C Foster
Comparison of lifelong and late life exercise on oxidative stress in the cerebellum.
Neurobiology of aging 2009;30(6):903-9.
2009: Tim Hofer; Stephane Servais; Arnold Young Seo; Emanuele Marzetti; Asimina Hiona; Shashank Jagdish Upadhyay; Stephanie E Wohlgemuth; Christiaan Leeuwenburgh
Bioenergetics and permeability transition pore opening in heart subsarcolemmal and interfibrillar mitochondria: effects of aging and lifelong calorie restriction.
Mechanisms of ageing and development 2009;130(5):297-307.
2009: Emanuele Marzetti; Christy S Carter; Stephanie E Wohlgemuth; Hazel A Lees; Silvia Giovannini; Barbara Anderson; LeBris S Quinn; Christiaan Leeuwenburgh
Changes in IL-15 expression and death-receptor apoptotic signaling in rat gastrocnemius muscle with aging and life-long calorie restriction.
Mechanisms of ageing and development 2009;130(4):272-80.
2009: Laura J Bailey; Tricia J Cluett; Aurelio Reyes; Tomas A Prolla; Joanna Poulton; Christiaan Leeuwenburgh; Ian J Holt
Mice expressing an error-prone DNA polymerase in mitochondria display elevated replication pausing and chromosomal breakage at fragile sites of mitochondrial DNA.
Nucleic acids research 2009;37(7):2327-35.
2009: Sunitha Rangaraju; David Hankins; Irina Madorsky; Evgenia Madorsky; Wei-Hua Lee; Christy S Carter; Christiaan Leeuwenburgh; Lucia Notterpek
Molecular architecture of myelinated peripheral nerves is supported by calorie restriction with aging.
Aging cell 2009;8(2):178-91.
2009: Emanuele Marzetti; Hazel Anne Lees; Stephanie Eva Wohlgemuth; Christiaan Leeuwenburgh
Sarcopenia of aging: underlying cellular mechanisms and protection by calorie restriction.
BioFactors (Oxford, England) 2009;35(1):28-35.
2009: Hae Young Chung; Matteo Cesari; Stephen Anton; Emanuele Marzetti; Silvia Giovannini; Arnold Y Seo; Christy Carter; Byung Pal Yu; Christiaan Leeuwenburgh
Molecular inflammation: underpinnings of aging and age-related diseases.
Ageing research reviews 2009;8(1):18-30.
2008: A M S Lezza; F P Fallacara; VITO PESCE; Christiaan Leeuwenburgh; Palmiro Cantatore; Maria Nicola Gadaleta
Localization of abasic sites and single-strand breaks in mitochondrial DNA from brain of aged rat, treated or not with caloric restriction diet.
Neurochemical research 2008;33(12):2609-14.
2008: Sivakumar Raghavan; Hordur G Kristinsson; Christiaan Leeuwenburgh
Radical scavenging and reducing ability of tilapia (Oreochromis niloticus) protein hydrolysates.
Journal of agricultural and food chemistry 2008;56(21):10359-67.
2008: Arnold Y Seo; Jinze Xu; Stephane Servais; Tim Hofer; Emanuele Marzetti; Stephanie E Wohlgemuth; Mitchell D Knutson; Hae Young Chung; Christiaan Leeuwenburgh
Mitochondrial iron accumulation with age and functional consequences.
Aging cell 2008;7(5):706-16.
2008: Mitchell D Knutson; Christiaan Leeuwenburgh
Resveratrol and novel potent activators of SIRT1: effects on aging and age-related diseases.
Nutrition reviews 2008;66(10):591-6.
2008: Silvia Giovannini; Emanuele Marzetti; Stephen E Borst; Christiaan Leeuwenburgh
Modulation of GH/IGF-1 axis: potential strategies to counteract sarcopenia in older adults.
Mechanisms of ageing and development 2008;129(10):593-601.
2008: John Strong; Richard A Miller; Clinton M Astle; Robert A Floyd; Kevin Flurkey; Kenneth Hensley; Martin A Javors; Christiaan Leeuwenburgh; James Nelson; Ennio Ongini; Nancy L Nadon; Huber R Warner; David E Harrison
Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice.
Aging cell 2008;7(5):641-50.
2008: Emanuele Marzetti; Stephanie E Wohlgemuth; Hazel Anne Lees; Hae-Young Chung; Silvia Giovannini; Christiaan Leeuwenburgh
Age-related activation of mitochondrial caspase-independent apoptotic signaling in rat gastrocnemius muscle.
Mechanisms of ageing and development 2008;129(9):542-9.
2008: Tim Hofer; luigi fontana; Stephen D Anton; Edward P Weiss; Dennis Villareal; Bhaskar Malayappan; Christiaan Leeuwenburgh
Long-term effects of caloric restriction or exercise on DNA and RNA oxidation levels in white blood cells and urine in humans.
Rejuvenation research 2008;11(4):793-9.
2008: Tim Hofer; Emanuele Marzetti; Jinze Xu; Arnold Y Seo; Sukru Gulec; Mitchell D Knutson; Christiaan Leeuwenburgh; Esther E Dupont-Versteegden
Increased iron content and RNA oxidative damage in skeletal muscle with aging and disuse atrophy.
Experimental gerontology 2008;43(6):563-70.
2008: Jong-Hee Kim; Hyo-Bum Kwak; Christiaan Leeuwenburgh; John M Lawler
Lifelong exercise and mild (8%) caloric restriction attenuate age-induced alterations in plantaris muscle morphology, oxidative stress and IGF-1 in the Fischer-344 rat.
Experimental gerontology 2008;43(4):317-29.
2008: Jae Heun Chung; Arnold Y Seo; Sang Woon Chung; Mi Kyung Kim; Christiaan Leeuwenburgh; Byung Pal Yu; Hae Young Chung
Molecular mechanism of PPAR in the regulation of age-related inflammation.
Ageing research reviews 2008;7(2):126-36.
2008: Emanuele Marzetti; Leanne Groban; Stephanie E Wohlgemuth; Hazel A Lees; Marina Lin; Harrison Jobe; Silvia Giovannini; Christiaan Leeuwenburgh; Christy S Carter
Effects of short-term GH supplementation and treadmill exercise training on physical performance and skeletal muscle apoptosis in old rats.
American journal of physiology. Regulatory, integrative and comparative physiology 2008;294(2):R558-67.
2008: Emanuele Marzetti; John M Lawler; Asimina Hiona; Todd Manini; Arnold Y Seo; Christiaan Leeuwenburgh
Modulation of age-induced apoptotic signaling and cellular remodeling by exercise and calorie restriction in skeletal muscle.
Free radical biology & medicine 2008;44(2):160-8.
2008: Jinze Xu; Mitchell D Knutson; Christy S Carter; Christiaan Leeuwenburgh
Iron accumulation with age, oxidative stress and functional decline.
PloS one 2008;3(8):e2865.
2008: Jamie L Barger; Tsuyoshi Kayo; James M Vann; Edward B Arias; Jelai Wang; Timothy A Hacker; Ying Wang; Daniel Raederstorff; Jason D Morrow; Christiaan Leeuwenburgh; David Allison; Kurt W Saupe; Gregory D Cartee; Richard Weindruch; Tomas A Prolla
A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice.
PloS one 2008;3(6):e2264.
2008: Amie J Dirks Naylor; Christiaan Leeuwenburgh
Sarcopenia: the role of apoptosis and modulation by caloric restriction.
Exercise and sport sciences reviews 2008;36(1):19-24.
2008: Asimina Hiona; Christiaan Leeuwenburgh
The role of mitochondrial DNA mutations in aging and sarcopenia: implications for the mitochondrial vicious cycle theory of aging.
Experimental gerontology 2008;43(1):24-33.
2007: Bhaskar Malayappan; Timothy J Garrett; Mark Segal; Christiaan Leeuwenburgh
Urinary analysis of 8-oxoguanine, 8-oxoguanosine, fapy-guanine and 8-oxo-2'-deoxyguanosine by high-performance liquid chromatography-electrospray tandem mass spectrometry as a measure of oxidative stress.
Journal of chromatography. A 2007;1167(1):54-62.
2007: Christy S Carter; Tim Hofer; Arnold Y Seo; Christiaan Leeuwenburgh
Molecular mechanisms of life- and health-span extension: role of calorie restriction and exercise intervention.
Applied physiology, nutrition, and metabolism = Physiologie appliquée, nutrition et métabolisme 2007;32(5):954-66.
2007: Stephanie E Wohlgemuth; David Julian; Debora E Akin; Joanna Fried; Kristin Toscano; Christiaan Leeuwenburgh; William A Dunn
Autophagy in the heart and liver during normal aging and calorie restriction.
Rejuvenation research 2007;10(3):281-92.
2007: Richard A Miller; David E Harrison; Clinton M Astle; Robert A Floyd; Kevin Flurkey; Kenneth Hensley; Martin A Javors; Christiaan Leeuwenburgh; James Nelson; Ennio Ongini; Nancy L Nadon; Huber R Warner; John Strong
An Aging Interventions Testing Program: study design and interim report.
Aging cell 2007;6(4):565-75.
2007: Benedek Erdös; Christopher S Broxson; Tessa Landa; Philip J Scarpace; Christiaan Leeuwenburgh; Yi Zhang; Nihal Tümer
Effects of life-long caloric restriction and voluntary exercise on age-related changes in levels of catecholamine biosynthetic enzymes and angiotensin II receptors in the rat adrenal medulla and hypothalamus.
Experimental gerontology 2007;42(8):745-52.
2007: Stephen E Borst; Christine F Conover; Christy S Carter; Chris M Gregory; Emanuele Marzetti; Christiaan Leeuwenburgh; Krista Vandenborne; Thomas J Wronski
Anabolic effects of testosterone are preserved during inhibition of 5alpha-reductase.
American journal of physiology. Endocrinology and metabolism 2007;293(2):E507-14.
2007: Sharon Judge; Christiaan Leeuwenburgh
Cardiac mitochondrial bioenergetics, oxidative stress, and aging.
American journal of physiology. Cell physiology 2007;292(6):C1983-92.
2007: Alberto Sanz; Asimina Hiona; Gregory C Kujoth; Arnold Y Seo; Tim Hofer; Evelyn Kouwenhoven; Rizwan Kalani; Tomas A Prolla; Gustavo Barja; Christiaan Leeuwenburgh
Evaluation of sex differences on mitochondrial bioenergetics and apoptosis in mice.
Experimental gerontology 2007;42(3):173-82.
2006: Emanuele Marzetti; Christiaan Leeuwenburgh
Skeletal muscle apoptosis, sarcopenia and frailty at old age.
Experimental gerontology 2006;41(12):1234-8.
2006: Gregory C Kujoth; Christiaan Leeuwenburgh; Tomas A Prolla
Mitochondrial DNA mutations and apoptosis in mammalian aging.
Cancer research 2006;66(15):7386-9.
2006: Amie J Dirks; Christiaan Leeuwenburgh
Tumor necrosis factor alpha signaling in skeletal muscle: effects of age and caloric restriction.
The Journal of nutritional biochemistry 2006;17(8):501-8.
2006: Cinzia Maraldi; Stefano Volpato; Stephen B Kritchevsky; Matteo Cesari; Elena Andresen; Christiaan Leeuwenburgh; Tamara B Harris; Anne B Newman; Alka Kanaya; Karen C Johnson; Nicolas Rodondi; Marco Pahor
Impact of inflammation on the relationship among alcohol consumption, mortality, and cardiac events: the health, aging, and body composition study.
Archives of internal medicine 2006;166(14):1490-7.
2006: Matteo Cesari; Christiaan Leeuwenburgh; Fulvio Lauretani; Graziano Onder; Stefania Bandinelli; Cinzia Maraldi; Jack M Guralnik; Marco Pahor; Luigi Ferrucci
Frailty syndrome and skeletal muscle: results from the Invecchiare in Chianti study.
The American journal of clinical nutrition 2006;83(5):1142-8.
2006: Amie J Dirks; Tim Hofer; Emanuele Marzetti; Marco Pahor; Christiaan Leeuwenburgh
Mitochondrial DNA mutations, energy metabolism and apoptosis in aging muscle.
Ageing research reviews 2006;5(2):179-95.
2006: Thomas O Obisesan; Christiaan Leeuwenburgh; Robert E Ferrell; Dana Phares; Jennifer A McKenzie; Steven J Prior; James M. Hagberg
C-reactive protein genotype affects exercise training-induced changes in insulin sensitivity.
Metabolism: clinical and experimental 2006;55(4):453-60.
2006: Hidekazu Hatao; Shuji Oh-ishi; Masayuki Itoh; Christiaan Leeuwenburgh; Hideki Ohno; Tomomi Ookawara; Koji Kishi; Hisanaga Yagyu; Hiroyuki Nakamura; Takeshi Matsuoka
Effects of acute exercise on lung antioxidant enzymes in young and old rats.
Mechanisms of ageing and development 2006;127(4):384-90.
2006: Matteo Cesari; Stephen B Kritchevsky; Christiaan Leeuwenburgh; Marco Pahor
Oxidative damage and platelet activation as new predictors of mobility disability and mortality in elders.
Antioxidants & redox signaling 2006;8(3-4):609-19.
2006: Keith C DeRuisseau; Andreas N Kavazis; Sharon Judge; Zsolt Murlasits; Melissa A Deering; John C Quindry; Youngil Lee; Darin Falk; Christiaan Leeuwenburgh; Scott K Powers
Moderate caloric restriction increases diaphragmatic antioxidant enzyme mRNA, but not when combined with lifelong exercise.
Antioxidants & redox signaling 2006;8(3-4):539-47.
2006: Arnold Y Seo; Tim Hofer; Bokyung Sung; Sharon Judge; Hae Y Chung; Christiaan Leeuwenburgh
Hepatic oxidative stress during aging: effects of 8% long-term calorie restriction and lifelong exercise.
Antioxidants & redox signaling 2006;8(3-4):529-38.
2006: Christiaan Leeuwenburgh; Tomas A Prolla
Genetics, redox signaling, oxidative stress, and apoptosis in mammalian aging.
Antioxidants & redox signaling 2006;8(3-4):503-5.
2006: Rizwan Kalani; Sharon Judge; Christy Carter; Marco Pahor; Christiaan Leeuwenburgh
Effects of caloric restriction and exercise on age-related, chronic inflammation assessed by C-reactive protein and interleukin-6.
The journals of gerontology. Series A, Biological sciences and medical sciences 2006;61(3):211-7.
2006: Pasquale Cassano; A G Sciancalepore; A M S Lezza; Christiaan Leeuwenburgh; Palmiro Cantatore; Maria Nicola Gadaleta
Tissue-specific effect of age and caloric restriction diet on mitochondrial DNA content.
Rejuvenation research 2006;9(2):211-4.
2006: Tim Hofer; Arnold Y Seo; Mercedes Prudencio; Christiaan Leeuwenburgh
A method to determine RNA and DNA oxidation simultaneously by HPLC-ECD: greater RNA than DNA oxidation in rat liver after doxorubicin administration.
Biological chemistry 2006;387(1):103-11.
2006: Amie J Dirks; Christiaan Leeuwenburgh
Caloric restriction in humans: potential pitfalls and health concerns.
Mechanisms of ageing and development 2006;127(1):1-7.
2005: Sharon Judge; Young Mok Jang; Anthony Smith; Colin Selman; Tracey Phillips; John R Speakman; Tory Hagen; Christiaan Leeuwenburgh
Exercise by lifelong voluntary wheel running reduces subsarcolemmal and interfibrillar mitochondrial hydrogen peroxide production in the heart.
American journal of physiology. Regulatory, integrative and comparative physiology 2005;289(6):R1564-72.
2005: Pushpalatha Kakarla; Gurumurthy Vadluri; Kesireddy Sathyavelu Reddy; Christiaan Leeuwenburgh
Vulnerability of the mid aged rat myocardium to the age-induced oxidative stress: influence of exercise training on antioxidant defense system.
Free radical research 2005;39(11):1211-7.
2005: G C Kujoth; Asimina Hiona; Thomas D Pugh; Shinichi Someya; K Panzer; Stephanie E Wohlgemuth; Tim Hofer; Arnold Y Seo; R Sullivan; Wendy A Jobling; J D Morrow; Holly Van Remmen; John M Sedivy; Tatsuya Yamasoba; Masaru Tanokura; Richard Weindruch; Christiaan Leeuwenburgh; Tomas A Prolla
Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging.
Science (New York, N.Y.) 2005;309(5733):481-4.
2005: Colin Selman; Tracey Phillips; Jessica L Staib; Jackie S Duncan; Christiaan Leeuwenburgh; John R Speakman
Energy expenditure of calorically restricted rats is higher than predicted from their altered body composition.
Mechanisms of ageing and development 2005;126(6-7):783-93.
2005: Christiaan Leeuwenburgh; Cathy M Gurley; Beau A Strotman; Esther E Dupont-Versteegden
Age-related differences in apoptosis with disuse atrophy in soleus muscle.
American journal of physiology. Regulatory, integrative and comparative physiology 2005;288(5):R1288-96.
2005: Tracey Phillips; Christiaan Leeuwenburgh
Muscle fiber specific apoptosis and TNF-alpha signaling in sarcopenia are attenuated by life-long calorie restriction.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(6):668-70.
2005: Sharon Judge; Young Mok Jang; Anthony Smith; Tory Hagen; Christiaan Leeuwenburgh
Age-associated increases in oxidative stress and antioxidant enzyme activities in cardiac interfibrillar mitochondria: implications for the mitochondrial theory of aging.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(3):419-21.
2005: Amie J Dirks; Christiaan Leeuwenburgh
The role of apoptosis in age-related skeletal muscle atrophy.
Sports medicine (Auckland, N.Z.) 2005;35(6):473-83.
2005: Joshua T Selsby; Andrew R Judge; Tossaporn Yimlamai; Christiaan Leeuwenburgh; Stephen L Dodd
Life long calorie restriction increases heat shock proteins and proteasome activity in soleus muscles of Fisher 344 rats.
Experimental gerontology 2005;40(1-2):37-42.
2004: Barry Drew; Christiaan Leeuwenburgh
Ageing and subcellular distribution of mitochondria: role of mitochondrial DNA deletions and energy production.
Acta physiologica Scandinavica 2004;182(4):333-41.
2004: Young Mok Jang; Suma Kendaiah; Barry Drew; Tracey Phillips; Colin Selman; David Julian; Christiaan Leeuwenburgh
Doxorubicin treatment in vivo activates caspase-12 mediated cardiac apoptosis in both male and female rats.
FEBS letters 2004;577(3):483-90.
2004: Thomas O Obisesan; Christiaan Leeuwenburgh; Tracey Phillips; Robert E Ferrell; Dana Phares; Steven J Prior; James M. Hagberg
C-reactive protein genotypes affect baseline, but not exercise training-induced changes, in C-reactive protein levels.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(10):1874-9.
2004: Masayuki Itoh; Shuji Oh-ishi; Hidekazu Hatao; Christiaan Leeuwenburgh; Colin Selman; Hideki Ohno; Takako Kizaki; Hiroyuki Nakamura; Takeshi Matsuoka
Effects of dietary calcium restriction and acute exercise on the antioxidant enzyme system and oxidative stress in rat diaphragm.
American journal of physiology. Regulatory, integrative and comparative physiology 2004;287(1):R33-8.
2004: Ricardo Gredilla; Sharon Phaneuf; Colin Selman; Suma Kendaiah; Christiaan Leeuwenburgh; Gustavo Barja
Short-term caloric restriction and sites of oxygen radical generation in kidney and skeletal muscle mitochondria.
Annals of the New York Academy of Sciences 2004;1019():333-42.
2004: Pasquale Cassano; A M S Lezza; Christiaan Leeuwenburgh; Palmiro Cantatore; Maria Nicola Gadaleta
Measurement of the 4,834-bp mitochondrial DNA deletion level in aging rat liver and brain subjected or not to caloric restriction diet.
Annals of the New York Academy of Sciences 2004;1019():269-73.
2004: Asimina Hiona; Christiaan Leeuwenburgh
Effects of age and caloric restriction on brain neuronal cell death/survival.
Annals of the New York Academy of Sciences 2004;1019():96-105.
2004: Sharon Judge; Andrew R Judge; Tilman Grune; Christiaan Leeuwenburgh
Short-term CR decreases cardiac mitochondrial oxidant production but increases carbonyl content.
American journal of physiology. Regulatory, integrative and comparative physiology 2004;286(2):R254-9.
2004: Tracey Phillips; Christiaan Leeuwenburgh
Lifelong aspirin supplementation as a means to extending life span.
Rejuvenation research 2004;7(4):243-51.
2004: Amie J Dirks; Christiaan Leeuwenburgh
Aging and lifelong calorie restriction result in adaptations of skeletal muscle apoptosis repressor, apoptosis-inducing factor, X-linked inhibitor of apoptosis, caspase-3, and caspase-12.
Free radical biology & medicine 2004;36(1):27-39.
2004: David Julian; Christiaan Leeuwenburgh
Linkage between insulin and the free radical theory of aging.
American journal of physiology. Regulatory, integrative and comparative physiology 2004;286(1):R20-1.
2003: Tracey Phillips; April C Childs; Darlene M Dreon; Stephen Phinney; Christiaan Leeuwenburgh
A dietary supplement attenuates IL-6 and CRP after eccentric exercise in untrained males.
Medicine and science in sports and exercise 2003;35(12):2032-7.
2003: Anthony M Payne; Stephen L Dodd; Christiaan Leeuwenburgh
Life-long calorie restriction in Fischer 344 rats attenuates age-related loss in skeletal muscle-specific force and reduces extracellular space.
Journal of applied physiology (Bethesda, Md. : 1985) 2003;95(6):2554-62.
2003: Christiaan Leeuwenburgh
Role of apoptosis in sarcopenia.
The journals of gerontology. Series A, Biological sciences and medical sciences 2003;58(11):999-1001.
2003: Barry Drew; Christiaan Leeuwenburgh
Method for measuring ATP production in isolated mitochondria: ATP production in brain and liver mitochondria of Fischer-344 rats with age and caloric restriction.
American journal of physiology. Regulatory, integrative and comparative physiology 2003;285(5):R1259-67.
2003: Colin Selman; Suma Kendaiah; Ricardo Gredilla; Christiaan Leeuwenburgh
Increased hepatic apoptosis during short-term caloric restriction is not associated with an enhancement in caspase levels.
Experimental gerontology 2003;38(8):897-903.
2003: Rajani R J Shelke; Christiaan Leeuwenburgh
Lifelong caloric restriction increases expression of apoptosis repressor with a caspase recruitment domain (ARC) in the brain.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(3):494-6.
2003: Colin Selman; Christiaan Leeuwenburgh
The role of Id2 and apoptosis during skeletal muscle remodeling.
American journal of physiology. Regulatory, integrative and comparative physiology 2003;284(2):R538-9.
2003: Barry Drew; Sharon Phaneuf; Amie J Dirks; Colin Selman; Ricardo Gredilla; A M S Lezza; Gustavo Barja; Christiaan Leeuwenburgh
Effects of aging and caloric restriction on mitochondrial energy production in gastrocnemius muscle and heart.
American journal of physiology. Regulatory, integrative and comparative physiology 2003;284(2):R474-80.
2003: Colin Selman; Ricardo Gredilla; Sharon Phaneuf; Suma Kendaiah; Gustavo Barja; Christiaan Leeuwenburgh
Short-term caloric restriction and regulatory proteins of apoptosis in heart, skeletal muscle and kidney of Fischer 344 rats.
Biogerontology 2003;4(3):141-7.
2002: Pattie Green; Christiaan Leeuwenburgh
Mitochondrial dysfunction is an early indicator of doxorubicin-induced apoptosis.
Biochimica et biophysica acta 2002;1588(1):94-101.
2002: April C Childs; Sharon Phaneuf; Amie J Dirks; Tracey Phillips; Christiaan Leeuwenburgh
Doxorubicin treatment in vivo causes cytochrome C release and cardiomyocyte apoptosis, as well as increased mitochondrial efficiency, superoxide dismutase activity, and Bcl-2:Bax ratio.
Cancer research 2002;62(16):4592-8.
2002: Michael Pollack; Sharon Phaneuf; Amie J Dirks; Christiaan Leeuwenburgh
The role of apoptosis in the normal aging brain, skeletal muscle, and heart.
Annals of the New York Academy of Sciences 2002;959():93-107.
2002: Barry Drew; Christiaan Leeuwenburgh
Aging and the role of reactive nitrogen species.
Annals of the New York Academy of Sciences 2002;959():66-81.
2002: Amie J Dirks; Christiaan Leeuwenburgh
Apoptosis in skeletal muscle with aging.
American journal of physiology. Regulatory, integrative and comparative physiology 2002;282(2):R519-27.
2002: Sharon Phaneuf; Christiaan Leeuwenburgh
Cytochrome c release from mitochondria in the aging heart: a possible mechanism for apoptosis with age.
American journal of physiology. Regulatory, integrative and comparative physiology 2002;282(2):R423-30.
2001: M Pollack; Christiaan Leeuwenburgh
Apoptosis and aging: role of the mitochondria.
The journals of gerontology. Series A, Biological sciences and medical sciences 2001;56(11):B475-82.
2001: A Childs; C Jacobs; T Kaminski; Barry Halliwell; Christiaan Leeuwenburgh
Supplementation with vitamin C and N-acetyl-cysteine increases oxidative stress in humans after an acute muscle injury induced by eccentric exercise.
Free radical biology & medicine 2001;31(6):745-53.
2001: S Adams; Pattie Green; R Claxton; S Simcox; M V Williams; K Walsh; Christiaan Leeuwenburgh
Reactive carbonyl formation by oxidative and non-oxidative pathways.
Frontiers in bioscience : a journal and virtual library 2001;6():A17-24.
2001: Sharon Phaneuf; Christiaan Leeuwenburgh
Apoptosis and exercise.
Medicine and science in sports and exercise 2001;33(3):393-6.
1999: Scott K Powers; LL Ji; Christiaan Leeuwenburgh
Exercise training-induced alterations in skeletal muscle antioxidant capacity: a brief review.
Medicine and science in sports and exercise 1999;31(7):987-97.