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Mariano Barbacid

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TOP 3
Carmen Guerra; Mariano Barbacid
Genetically engineered mouse models of pancreatic adenocarcinoma.
Anton Berns; Mariano Barbacid
Mouse models of cancer.
Carolina Navas; Alberto J Schuhmacher; Maria Sibilia; Carmen Guerra; Isabel Hernández-Porras; Mariano Barbacid
EGF receptor signaling is essential for k-ras oncogene-driven pancreatic ductal adenocarcinoma.

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All Publications

2013: Carmen Guerra; Mariano Barbacid
Genetically engineered mouse models of pancreatic adenocarcinoma.
Molecular oncology 2013;7(2):232-47.
2013: Anton Berns; Mariano Barbacid
Mouse models of cancer.
Molecular oncology 2013;7(2):143-5.
2012: Carolina Navas; Alberto J Schuhmacher; Maria Sibilia; Carmen Guerra; Isabel Hernández-Porras; Mariano Barbacid
EGF receptor signaling is essential for k-ras oncogene-driven pancreatic ductal adenocarcinoma.
Cancer cell 2012;22(3):318-30.
2012: Sonia Martínez González; Genoveva Mateos; Francisca Mulero; Julen Oyarzabal; Pilar Pizcueta; Obdulia Rabal; Francisco Ramos-Lima; Carmen Varela; Enara Aguirre; M I Albarrán; Patricia Alfonso; Mariano Barbacid; James R Bischoff; Carmen Blanco-Aparicio; David Cebrián; Elena Cendón; Jesús Fominaya; Beatriz García-Serelde; Elena Gomez-Casero; Teresa Gonzalez-Granda; Ana Isabel Hernández; Wolfgang Link; Milagros Lorenzo; Joaquín Pastor
Rapid identification of ETP-46992, orally bioavailable PI3K inhibitor, selective versus mTOR.
Bioorganic & medicinal chemistry letters 2012;22(16):5208-14.
2012: Miguel Ganuza; Gonzalo Gómez; Jesus Paramio; David Pisano; Cristina Sáiz-Ladera; David Santamaría; Ralph Schneider; María A Blasco; Marta Cañamero; Mariano Barbacid
Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion.
The EMBO journal 2012;31(11):2498-510.
2012: Mariano Barbacid
Opening a new GATAway for treating KRAS-driven lung tumors.
Cancer cell 2012;21(5):598-600.
2012: Sonia Martínez González; Francisca Mulero; Julen Oyarzabal; Enara Aguirre; Maribel Albarrán; Patricia Alfonso; Mariano Barbacid; James R Bischoff; David Cebrián; Elena Cendón; Jesús Fominaya; Beatriz García-Serelde; Elena Gomez-Casero; Teresa Gonzalez-Granda; Ana Isabel Hernández; Wolfgang Link; Milagros Lorenzo; José Ignacio Martín; Pilar Pizcueta; Obdulia Rabal; Francisco Ramos-Lima; Virginia Rivero; Antonio Rodríguez; Sonsoles Rodríguez-Arístegui; Carl Gustav Saluste; Carmen Varela; Joaquín Pastor
Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
Bioorganic & medicinal chemistry letters 2012;22(10):3460-6.
2012: Pedro A Pérez-Mancera; Mariano Barbacid; Carmen Guerra; David A Tuveson
What we have learned about pancreatic cancer from mouse models.
Gastroenterology 2012;142(5):1079-92.
2011: Matilde Murga; Thomas Schleker; Rebeca Soria; Luis I Toledo; Bruno Amati; Mariano Barbacid; Stefano Campaner; Luana D'Artista; Elena Garcia; Carmen Guerra; Manuel Hidalgo; Andres J Lopez-Contreras; Maria F Montaña; Oscar Fernandez-Capetillo
Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors.
Nature structural & molecular biology 2011;18(12):1331-5.
2011: Elizabeth J Hennessy; David Santamaria; Frederick J Sheedy; Mariano Barbacid; Luke A J O'Neill
Toll-like receptor-4 (TLR4) down-regulates microRNA-107, increasing macrophage adhesion via cyclin-dependent kinase 6.
The Journal of biological chemistry 2011;286(29):25531-9.
2011: Christian Göritz; Oleg Shupliakov; Nikolay Tomilin; Mariano Barbacid; David O Dias; Jonas Frisén
A pericyte origin of spinal cord scar tissue.
Science (New York, N.Y.) 2011;333(6039):238-42.
2011: Carmen Guerra; Isabel Hernández-Porras; Carolina Navas; Manuel Rodriguez-Justo; Alberto J Schuhmacher; Manuel Serrano; Marta Cañamero; Manuel Collado; Mariano Barbacid
Pancreatitis-induced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescence.
Cancer cell 2011;19(6):728-39.
2011: Rafael B Blasco; Sarah Francoz; David Santamaría; Marta Cañamero; Pierre Dubus; Jean Charron; Manuela Baccarini; Mariano Barbacid
c-Raf, but not B-Raf, is essential for development of K-Ras oncogene-driven non-small cell lung carcinoma.
Cancer cell 2011;19(5):652-63.
2011: Pierre Beukelaers; Renaud Vandenbosch; Nicolas Caron; Laurent Nguyen; Shibeshih Belachew; Gustave Moonen; Hiroaki Kiyokawa; Mariano Barbacid; David Santamaria; Brigitte Malgrange
Cdk6-dependent regulation of G(1) length controls adult neurogenesis.
Stem cells (Dayton, Ohio) 2011;29(4):713-24.
2011: Jelena Urosevic; Vincent Sauzeau; María L Soto-Montenegro; Santiago Reig; Manuel Desco; Emma M Burkitt Wright; Marta Cañamero; Francisca Mulero; Sagrario Ortega; Xosé R Bustelo; Mariano Barbacid
Constitutive activation of B-Raf in the mouse germ line provides a model for human cardio-facio-cutaneous syndrome.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(12):5015-20.
2010: Stephen Hyter; Gaurav Bajaj; Xiaobo Liang; Mariano Barbacid; Gitali Ganguli-Indra; Arup Kumar Indra
Loss of nuclear receptor RXRα in epidermal keratinocytes promotes the formation of Cdk4-activated invasive melanomas.
Pigment cell & melanoma research 2010;23(5):635-48.
2010: Marta Puyol; Alberto Martín; Pierre Dubus; Francisca Mulero; Pilar Pizcueta; Gulfaraz Khan; Carmen Guerra; David Santamaría; Mariano Barbacid
A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma.
Cancer cell 2010;18(1):63-73.
2010: Matthias Lauth; Asa Bergström; Takashi Shimokawa; Ulrica Tostar; Qianren Jin; Volker Fendrich; Carmen Guerra; Mariano Barbacid; Rune Toftgård
DYRK1B-dependent autocrine-to-paracrine shift of Hedgehog signaling by mutant RAS.
Nature structural & molecular biology 2010;17(6):718-25.
2010: Matthias Drosten; Alma Dhawahir; Eleanor Y M Sum; Jelena Urosevic; Carmen G Lechuga; Luis M Esteban; Esther Castellano; Carmen Guerra; Eugenio Santos; Mariano Barbacid
Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival.
The EMBO journal 2010;29(6):1091-104.
2010: Stefano Campaner; Mirko Doni; Per Hydbring; Alessandro Verrecchia; Lucia Bianchi; Domenico Sardella; Thomas Schleker; Daniele Perna; Susanna Tronnersjö; Matilde Murga; Oscar Fernandez-Capetillo; Mariano Barbacid; Lars-Gunnar Larsson; Bruno Amati
Cdk2 suppresses cellular senescence induced by the c-myc oncogene.
Nature cell biology 2010;12(1):54-9; sup pp 1-14.
2009: Antonio Cerqueira; David Santamaría; Bárbara Martínez-Pastor; Miriam Cuadrado; Oscar Fernández-Capetillo; Mariano Barbacid
Overall Cdk activity modulates the DNA damage response in mammalian cells.
The Journal of cell biology 2009;187(6):773-80.
2009: Jelena Urosevic; Eleanor Y M Sum; Victoria Moneo; Matthias Drosten; Alma Dhawahir; Mercedes Becerra; Amancio Carnero; Mariano Barbacid
Using cells devoid of RAS proteins as tools for drug discovery.
Molecular carcinogenesis 2009;48(11):1038-47.
2009: Carles Martínez-Romero; Ilse Rooman; Anouchka Skoudy; Carmen Guerra; Xavier Molero; Ana González; Mar Iglesias; Tania Lobato; Almudena Bosch; Mariano Barbacid; Francisco X Real; Inmaculada Hernández-Muñoz
The epigenetic regulators Bmi1 and Ring1B are differentially regulated in pancreatitis and pancreatic ductal adenocarcinoma.
The Journal of pathology 2009;219(2):205-13.
2009: Marcos Malumbres; Mariano Barbacid
Cell cycle, CDKs and cancer: a changing paradigm.
Nature reviews. Cancer 2009;9(3):153-66.
2008: P Boyle; B O Anderson; L C Andersson; Y Ariyaratne; G-R Auleley; Mariano Barbacid; H Bartelink; J Baselga; K Behbehani; F Belardelli; A Berns; J Bishop; O Brawley; H Burns; M Clanton; B Cox; david currow; J-M Dangou; D de Valeriola; Satish Munnolli; A Eggermont; J Fitzpatrick; M Forstmane; E Garaci; A T Gavin; T Kakizoe; M Kasler; N Keita; D Kerr; D Khayat; S Khleif; T Khuhaprema; T Knezevic; R Kubinova; M Mallath; J Martin-Moreno; D McCance; J G McVie; A Merriman; T Ngoma; M Nowacki; J Orgelbrand; J-G Park; M Pierotti; L P Ashton; P Puska; C V R Escobar; B Rajan; THANGARAJAN RAJKUMAR; U Ringborg; C Robertson; A Rodger; L Roovali; L A Santini; M Sarhan; J Seffrin; V Semiglazov; B M Shrestha; K C Soo; V Stamenic; C Tamblyn; R Thomas; M Tuncer; T Tursz; R Vaitkiene; C Vallejos; U Veronesi; A Wojtyla; derek yach; K-Y Yoo; W Zatonski; D Zaridze; Y-X Zeng; P Zhao; Tao Zheng
Need for global action for cancer control.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2008;19(9):1519-21.
2008: Alberto J Schuhmacher; Carmen Guerra; Vincent Sauzeau; Marta Cañamero; Xose Bustelo; Mariano Barbacid
A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition.
The Journal of clinical investigation 2008;118(6):2169-79.
2008: Suzana Atanasoski; Matthias Boentert; Lukas De Ventura; Hartmut Pohl; Constanze Baranek; Konstantin Beier; Peter Young; Mariano Barbacid; Ueli Suter
Postnatal Schwann cell proliferation but not myelination is strictly and uniquely dependent on cyclin-dependent kinase 4 (cdk4).
Molecular and cellular neurosciences 2008;37(3):519-27.
2008: Marcos Malumbres; Paolo Pevarello; Mariano Barbacid; James R Bischoff
CDK inhibitors in cancer therapy: what is next?
Trends in pharmacological sciences 2008;29(1):16-21.
2007: David Santamaría; Cédric Barrière; Antonio Cerqueira; Sarah Hunt; Claudine Tardy; Kathryn Newton; Javier F Cáceres; Pierre Dubus; Marcos Malumbres; Mariano Barbacid
Cdk1 is sufficient to drive the mammalian cell cycle.
Nature 2007;448(7155):811-5.
2007: Cédric Barrière; David Santamaría; Antonio Cerqueira; Javier Galán; Alberto Martín; Sagrario Ortega; Marcos Malumbres; Pierre Dubus; Mariano Barbacid
Mice thrive without Cdk4 and Cdk2.
Molecular oncology 2007;1(1):72-83.
2007: Juan José Ventura; Stephan Tenbaum; Eusebio Perdiguero; Marion Huth; Carmen Guerra; Mariano Barbacid; Manolis Pasparakis; Angel R Nebreda
p38alpha MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation.
Nature genetics 2007;39(6):750-8.
2007: Mariano Barbacid
Returning home.
Cell 2007;129(4):641-4.
2007: Carmen Guerra; Alberto J Schuhmacher; Marta Cañamero; Paul J Grippo; Lena Verdaguer; Lucía Pérez-Gallego; Pierre Dubus; Eric P Sandgren; Mariano Barbacid
Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice.
Cancer cell 2007;11(3):291-302.
2007: Marcos Malumbres; Mariano Barbacid
Cell cycle kinases in cancer.
Current opinion in genetics & development 2007;17(1):60-5.
2006: Owen J Sansom; Valerie Meniel; Julie A Wilkins; Alicia M Cole; Karin A Oien; Victoria Marsh; Thomas J Jamieson; Carmen Guerra; Gabrielle H Ashton; Mariano Barbacid; Alan R Clarke
Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(38):14122-7.
2006: Damia Tormo; Aleix Ferrer; Evelyn Gaffal; Joerg Wenzel; Etiena Basner-Tschakarjan; Julia Steitz; Lukas Heukamp; Ines Gütgemann; Reinhard Buettner; Marcos Malumbres; Mariano Barbacid; Glenn Merlino; Thomas Tüting
Rapid growth of invasive metastatic melanoma in carcinogen-treated hepatocyte growth factor/scatter factor-transgenic mice carrying an oncogenic CDK4 mutation.
The American journal of pathology 2006;169(2):665-72.
2006: Anette Duensing; Youhua Liu; Michelle Tseng; Marcos Malumbres; Mariano Barbacid; Stefan Duensing
Cyclin-dependent kinase 2 is dispensable for normal centrosome duplication but required for oncogene-induced centrosome overduplication.
Oncogene 2006;25(20):2943-9.
2006: Elke Hacker; H Konrad Muller; Nicole Irwin; Brian Gabrielli; Douglas Lincoln; Sandra Pavey; Marianne Powell; Marcos Malumbres; Mariano Barbacid; Nicholas Hayward; Graeme Walker
Spontaneous and UV radiation-induced multiple metastatic melanomas in Cdk4R24C/R24C/TPras mice.
Cancer research 2006;66(6):2946-52.
2006: Julia Steitz; Stefanie Büchs; Damia Tormo; Aleix Ferrer; Joerg Wenzel; Christoph Huber; Thomas Wölfel; Mariano Barbacid; Marcos Malumbres; Thomas Tüting
Evaluation of genetic melanoma vaccines in cdk4-mutant mice provides evidence for immunological tolerance against authochthonous melanomas in the skin.
International journal of cancer. Journal international du cancer 2006;118(2):373-80.
2006: Marcos Malumbres; Mariano Barbacid
Is Cyclin D1-CDK4 kinase a bona fide cancer target?
Cancer cell 2006;9(1):2-4.
2005: Marcos Malumbres; Mariano Barbacid
Mammalian cyclin-dependent kinases.
Trends in biochemical sciences 2005;30(11):630-41.
2005: Anna Abella; Pierre Dubus; Marcos Malumbres; Sushil G Rane; Hiroaki Kiyokawa; Audrey Sicard; Françoise Vignon; Dominique Langin; Mariano Barbacid; Lluis Fajas
Cdk4 promotes adipogenesis through PPARgamma activation.
Cell metabolism 2005;2(4):239-49.
2005: Manuel Collado; Jesús Gil; Alejo Efeyan; Carmen Guerra; Alberto J Schuhmacher; Marta Barradas; Alberto Benguría; Angel Zaballos; Juana M Flores; Mariano Barbacid; David Beach; Manuel Serrano
Tumour biology: senescence in premalignant tumours.
Nature 2005;436(7051):642.
2005: Alberto Martín; Junko Odajima; Sarah L Hunt; Pierre Dubus; Sagrario Ortega; Marcos Malumbres; Mariano Barbacid
Cdk2 is dispensable for cell cycle inhibition and tumor suppression mediated by p27(Kip1) and p21(Cip1).
Cancer cell 2005;7(6):591-8.
2005: Rocío Sotillo; Oliver Renner; Pierre Dubus; Jesús Ruiz-Cabello; Juan Martín-Caballero; Mariano Barbacid; Amancio Carnero; Marcos Malumbres
Cooperation between Cdk4 and p27kip1 in tumor development: a preclinical model to evaluate cell cycle inhibitors with therapeutic activity.
Cancer research 2005;65(9):3846-52.
2005: Nieves Mijimolle; Juan Velasco; Pierre Dubus; Carmen Guerra; Carolyn A Weinbaum; Patrick J Casey; Victoria Campuzano; Mariano Barbacid
Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development.
Cancer cell 2005;7(4):313-24.
2005: Mariano Barbacid; Sagrario Ortega; Rocío Sotillo; Junko Odajima; Alberto Martín; David Santamaría; Pierre Dubus; Marcos Malumbres
Cell cycle and cancer: genetic analysis of the role of cyclin-dependent kinases.
Cold Spring Harbor symposia on quantitative biology 2005;70():233-40.
2004: Johan Auwerx; Phil Avner; Richard Baldock; Andrea Ballabio; Rudi Balling; Mariano Barbacid; Anton Berns; Allan Bradley; Steve Brown; Peter Carmeliet; Pierre Chambon; Roger Cox; Duncan Davidson; Kay Davies; Denis Duboule; Jiri Forejt; Francesca Granucci; Nick Hastie; Martin Hrabé de Angelis; Ian Jackson; Dimitris Kioussis; george kollias; Mark Lathrop; Urban Lendahl; Marcos Malumbres; Harald von Melchner; Werner Muller; Juha Partanen; Paola Ricciardi-Castagnoli; Peter Rigby; Barry P Rosen; Nadia Rosenthal; Bill Skarnes; A Francis Stewart; Janet Thornton; Glauco Tocchini-Valentini; Erwin Wagner; Walter Wahli; Wolfgang Wurst
The European dimension for the mouse genome mutagenesis program.
Nature genetics 2004;36(9):925-7.
2004: Marcos Malumbres; Rocío Sotillo; David Santamaría; Javier Galán; Ana Cerezo; Sagrario Ortega; Pierre Dubus; Mariano Barbacid
Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6.
Cell 2004;118(4):493-504.
2003: Sagrario Ortega; Ignacio Prieto; Junko Odajima; Alberto Martín; Pierre Dubus; Rocío Sotillo; José L Barbero; Marcos Malumbres; Mariano Barbacid
Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice.
Nature genetics 2003;35(1):25-31.
2003: Javier Martín; Sarah L Hunt; Pierre Dubus; Rocío Sotillo; Fanny Néhmé-Pélluard; Mark Magnuson; Albert F Parlow; Marcos Malumbres; Sagrario Ortega; Mariano Barbacid
Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number.
Oncogene 2003;22(34):5261-9.
2003: Carmen Guerra; Nieves Mijimolle; Alma Dhawahir; Pierre Dubus; Marta Barradas; Manuel Serrano; Victoria Campuzano; Mariano Barbacid
Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context.
Cancer cell 2003;4(2):111-20.
2003: Marcos Malumbres; Mariano Barbacid
RAS oncogenes: the first 30 years.
Nature reviews. Cancer 2003;3(6):459-65.
2003: Marcos Malumbres; Sarah L Hunt; Rocío Sotillo; Javier Martín; Junko Odajima; Alberto Martín; Pierre Dubus; Sagrario Ortega; Mariano Barbacid
Driving the cell cycle to cancer.
Advances in experimental medicine and biology 2003;532():1-11.
2002: Sagrario Ortega; Marcos Malumbres; Mariano Barbacid
Cyclin D-dependent kinases, INK4 inhibitors and cancer.
Biochimica et biophysica acta 2002;1602(1):73-87.
2002: Mariano Barbacid
Mariano Barbacid: director of Spain's first national cancer centre. Interviewed by Adrian Burton.
The lancet oncology 2002;3(2):118-23.
2001: Rocío Sotillo; Pierre Dubus; Javier Martín; E de la Cueva; Sagrario Ortega; Marcos Malumbres; Mariano Barbacid
Wide spectrum of tumors in knock-in mice carrying a Cdk4 protein insensitive to INK4 inhibitors.
The EMBO journal 2001;20(23):6637-47.
2001: Marcos Malumbres; Mariano Barbacid
To cycle or not to cycle: a critical decision in cancer.
Nature reviews. Cancer 2001;1(3):222-31.
2001: Rocío Sotillo; J F García; Sagrario Ortega; J Martin; Pierre Dubus; Mariano Barbacid; Marcos Malumbres
Invasive melanoma in Cdk4-targeted mice.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(23):13312-7.
2001: Frederique Zindy; Willem den Besten; B Chen; Jerold E Rehg; E Latres; Mariano Barbacid; Jeffrey W Pollard; Charles J Sherr; Paula E Cohen; Martine F Roussel
Control of spermatogenesis in mice by the cyclin D-dependent kinase inhibitors p18(Ink4c) and p19(Ink4d).
Molecular and cellular biology 2001;21(9):3244-55.
2001: Saburou Matsuo; Hiroyuki Ichikawa; T A Henderson; Inmaculada Silos-Santiago; Mariano Barbacid; Joop J A Arends; Mark F Jacquin
trkA modulation of developing somatosensory neurons in oro-facial tissues: tooth pulp fibers are absent in trkA knockout mice.
Neuroscience 2001;105(3):747-60.
2000: Marcos Malumbres; Sagrario Ortega; Mariano Barbacid
Genetic analysis of mammalian cyclin-dependent kinases and their inhibitors.
Biological chemistry 2000;381(9-10):827-38.
2000: E Latres; Marcos Malumbres; Rocío Sotillo; Javier Martín; Sagrario Ortega; Juan Martín-Caballero; Juana M Flores; Carlos Cordón-Cardo; Mariano Barbacid
Limited overlapping roles of P15(INK4b) and P18(INK4c) cell cycle inhibitors in proliferation and tumorigenesis.
The EMBO journal 2000;19(13):3496-506.
2000: David A Feldheim; Y I Kim; A D Bergemann; Jonas Frisén; Mariano Barbacid; John G Flanagan
Genetic analysis of ephrin-A2 and ephrin-A5 shows their requirement in multiple aspects of retinocollicular mapping.
Neuron 2000;25(3):563-74.
1999: Jonas Frisén; Johan Holmberg; Mariano Barbacid
Ephrins and their Eph receptors: multitalented directors of embryonic development.
The EMBO journal 1999;18(19):5159-65.
1999: Sushil G Rane; Pierre Dubus; Richard V Mettus; Elizabeth Galbreath; G Boden; E Premkumar Reddy; Mariano Barbacid
Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia.
Nature genetics 1999;22(1):44-52.
1998: David A Feldheim; Pierre Vanderhaeghen; Michael J Hansen; Jonas Frisén; Q Lu; Mariano Barbacid; John G Flanagan
Topographic guidance labels in a sensory projection to the forebrain.
Neuron 1998;21(6):1303-13.
1998: Bernd Fritzsch; Mariano Barbacid; Inmaculada Silos-Santiago
Nerve dependency of developing and mature sensory receptor cells.
Annals of the New York Academy of Sciences 1998;855():14-27.
1998: Bernd Fritzsch; Mariano Barbacid; Inmaculada Silos-Santiago
The combined effects of trkB and trkC mutations on the innervation of the inner ear.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 1998;16(6):493-505.
1998: Albert Martínez; Soledad Alcántara; Victor Borrell; José A del Río; Juan Blasi; Raquel Otal; Narciso Campos; Albert Boronat; Mariano Barbacid; Inmaculada Silos-Santiago; Eduardo Soriano
TrkB and TrkC signaling are required for maturation and synaptogenesis of hippocampal connections.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(18):7336-50.
1998: Frank rice; Kathryn M Albers; Brian M Davis; Inmaculada Silos-Santiago; George A Wilkinson; AM LeMaster; Patrik Ernfors; R J Smeyne; Håkan Aldskogius; Heidi S Phillips; Mariano Barbacid; T M DeChiara; G D Yancopoulos; C E Dunne; Bengt T Fundin
Differential dependency of unmyelinated and A delta epidermal and upper dermal innervation on neurotrophins, trk receptors, and p75LNGFR.
Developmental biology 1998;198(1):57-81.
1998: Jonas Frisén; Paul Yates; Todd McLaughlin; G C Friedman; Dennis D M O'Leary; Mariano Barbacid
Ephrin-A5 (AL-1/RAGS) is essential for proper retinal axon guidance and topographic mapping in the mammalian visual system.
Neuron 1998;20(2):235-43.
1998: F de Castro; Inmaculada Silos-Santiago; Mikel López de Armentia; Mariano Barbacid; carlos belmonte
Corneal innervation and sensitivity to noxious stimuli in trkA knockout mice.
The European journal of neuroscience 1998;10(1):146-52.
1997: Xose Bustelo; Piero Crespo; M López-Barahona; J Silvio Gutkind; Mariano Barbacid
Cbl-b, a member of the Sli-1/c-Cbl protein family, inhibits Vav-mediated c-Jun N-terminal kinase activation.
Oncogene 1997;15(21):2511-20.
1997: Jonas Frisén; Mariano Barbacid
Genetic analysis of the role of Eph receptors in the development of the mammalian nervous system.
Cell and tissue research 1997;290(2):209-15.
1997: Anne M Fagan; M Garber; Mariano Barbacid; Inmaculada Silos-Santiago; David M Holtzman
A role for TrkA during maturation of striatal and basal forebrain cholinergic neurons in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(20):7644-54.
1997: Inmaculada Silos-Santiago; A M Fagan; M Garber; Bernd Fritzsch; Mariano Barbacid
Severe sensory deficits but normal CNS development in newborn mice lacking TrkB and TrkC tyrosine protein kinase receptors.
The European journal of neuroscience 1997;9(10):2045-56.
1997: Bengt T Fundin; Inmaculada Silos-Santiago; Patrik Ernfors; A M Fagan; Håkan Aldskogius; T M DeChiara; Heidi S Phillips; Mariano Barbacid; G D Yancopoulos; Frank rice
Differential dependency of cutaneous mechanoreceptors on neurotrophins, trk receptors, and P75 LNGFR.
Developmental biology 1997;190(1):94-116.
1997: J L Rosa; Mariano Barbacid
A giant protein that stimulates guanine nucleotide exchange on ARF1 and Rab proteins forms a cytosolic ternary complex with clathrin and Hsp70.
Oncogene 1997;15(1):1-6.
1997: Bernd Fritzsch; P A Sarai; Mariano Barbacid; Inmaculada Silos-Santiago
Mice with a targeted disruption of the neurotrophin receptor trkB lose their gustatory ganglion cells early but do develop taste buds.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 1997;15(4-5):563-76.
1997: S Park; Jonas Frisén; Mariano Barbacid
Aberrant axonal projections in mice lacking EphA8 (Eek) tyrosine protein kinase receptors.
The EMBO journal 1997;16(11):3106-14.
1997: Soledad Alcántara; Jonas Frisén; José A del Río; Eduardo Soriano; Mariano Barbacid; Inmaculada Silos-Santiago
TrkB signaling is required for postnatal survival of CNS neurons and protects hippocampal and motor neurons from axotomy-induced cell death.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(10):3623-33.
1997: Y Yan; Jonas Frisén; M H Lee; J Massagué; Mariano Barbacid
Ablation of the CDK inhibitor p57Kip2 results in increased apoptosis and delayed differentiation during mouse development.
Genes & development 1997;11(8):973-83.
1996: Anne M Fagan; H Zhang; S Landis; Richard J Smeyne; Inmaculada Silos-Santiago; Mariano Barbacid
TrkA, but not TrkC, receptors are essential for survival of sympathetic neurons in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(19):6208-18.
1996: J L Rosa; Ricardo P Casaroli-Marano; A J Buckler; S Vilaró; Mariano Barbacid
p619, a giant protein related to the chromosome condensation regulator RCC1, stimulates guanine nucleotide exchange on ARF1 and Rab proteins.
The EMBO journal 1996;15(16):4262-73.
1996: Fletcher White; Inmaculada Silos-Santiago; Derek C Molliver; M Nishimura; H Phillips; Mariano Barbacid; William D Snider
Synchronous onset of NGF and TrkA survival dependence in developing dorsal root ganglia.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(15):4662-72.
1996: Piero Crespo; Xose Bustelo; D S Aaronson; O A Coso; M Lopez-Barahona; Mariano Barbacid; J Silvio Gutkind
Rac-1 dependent stimulation of the JNK/SAPK signaling pathway by Vav.
Oncogene 1996;13(3):455-60.
1996: Kornel E Schuebel; Xose Bustelo; DA Nielsen; Byoung J Song; Mariano Barbacid; David Goldman; I J Lee
Isolation and characterization of murine vav2, a member of the vav family of proto-oncogenes.
Oncogene 1996;13(2):363-71.
1996: M P Sánchez; Inmaculada Silos-Santiago; Jonas Frisén; B He; sergio lira; Mariano Barbacid
Renal agenesis and the absence of enteric neurons in mice lacking GDNF.
Nature 1996;382(6586):70-3.
1996: M López-Barahona; Xose Bustelo; Mariano Barbacid
The TC21 oncoprotein interacts with the Ral guanosine nucleotide dissociation factor.
Oncogene 1996;12(3):463-70.
1996: K Leftheris; T Kline; G D Vite; Y H Cho; R S Bhide; D V Patel; M M Patel; R J Schmidt; H N Weller; M L Andahazy; J M Carboni; J L Gullo-Brown; F Y Lee; C Ricca; W C Rose; N Yan; Mariano Barbacid; John T Hunt; C A Meyers; B R Seizinger; Robert Zahler; swam manne
Development of highly potent inhibitors of Ras farnesyltransferase possessing cellular and in vivo activity.
Journal of medicinal chemistry 1996;39(1):224-36.
1995: K L Suen; Xose Bustelo; Mariano Barbacid
Lack of evidence for the activation of the Ras/Raf mitogenic pathway by 14-3-3 proteins in mammalian cells.
Oncogene 1995;11(5):825-31.
1995: Mariano Barbacid
Structural and functional properties of the TRK family of neurotrophin receptors.
Annals of the New York Academy of Sciences 1995;766():442-58.
1995: Inmaculada Silos-Santiago; Derek C Molliver; S Ozaki; Richard J Smeyne; Anne M Fagan; Mariano Barbacid; William D Snider
Non-TrkA-expressing small DRG neurons are lost in TrkA deficient mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(9):5929-42.
1995: J M Carboni; N Yan; Adrienne D Cox; X Bustelo; S M Graham; M J Lynch; roberto weinmann; B R Seizinger; Channing J Der; Mariano Barbacid
Farnesyltransferase inhibitors are inhibitors of Ras but not R-Ras2/TC21, transformation.
Oncogene 1995;10(10):1905-13.
1995: Mariano Barbacid
Neurotrophic factors and their receptors.
Current opinion in cell biology 1995;7(2):148-55.
1995: Xose Bustelo; K L Suen; majid shafaee; G Dreyfuss; Mariano Barbacid
Association of the vav proto-oncogene product with poly(rC)-specific RNA-binding proteins.
Molecular and cellular biology 1995;15(3):1324-32.
1995: D V Patel; E M Gordon; R J Schmidt; H N Weller; M G Young; Robert Zahler; Mariano Barbacid; J M Carboni; J L Gullo-Brown; L Hunihan
Phosphinyl acid-based bisubstrate analog inhibitors of Ras farnesyl protein transferase.
Journal of medicinal chemistry 1995;38(3):435-42.
1995: A Zmuidzinas; K D Fischer; sergio lira; Lesley Forrester; S Bryant; A Bernstein; Mariano Barbacid
The vav proto-oncogene is required early in embryogenesis but not for hematopoietic development in vitro.
The EMBO journal 1995;14(1):1-11.
1994: Michael Wittekind; C Mapelli; Bennett T Farmer; K L Suen; Valentina Goldfarb; J Tsao; T Lavoie; Mariano Barbacid; C A Meyers; Luciano Mueller
Orientation of peptide fragments from Sos proteins bound to the N-terminal SH3 domain of Grb2 determined by NMR spectroscopy.
Biochemistry 1994;33(46):13531-9.
1994: Mariano Barbacid
The Trk family of neurotrophin receptors.
Journal of neurobiology 1994;25(11):1386-403.
1994: Xose Bustelo; K L Suen; K Leftheris; C A Meyers; Mariano Barbacid
Vav cooperates with Ras to transform rodent fibroblasts but is not a Ras GDP/GTP exchange factor.
Oncogene 1994;9(8):2405-13.
1994: R Klein; Inmaculada Silos-Santiago; Richard J Smeyne; sergio lira; R Brambilla; S Bryant; L Zhang; William D Snider; Mariano Barbacid
Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements.
Nature 1994;368(6468):249-51.
1994: Richard J Smeyne; R Klein; A Schnapp; L K Long; S Bryant; A Lewin; sergio lira; Mariano Barbacid
Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene.
Nature 1994;368(6468):246-9.
1994: M P Sánchez; P Tapley; Shamsher Saini; B He; D Pulido; Mariano Barbacid
Multiple tyrosine protein kinases in rat hippocampal neurons: isolation of Ptk-3, a receptor expressed in proliferative zones of the developing brain.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(5):1819-23.
1994: Xiaoyun Zhu; K L Suen; Mariano Barbacid; J B Bolen; J Fargnoli
Interleukin-2-induced tyrosine phosphorylation of Shc proteins correlates with factor-dependent T cell proliferation.
The Journal of biological chemistry 1994;269(8):5518-22.
1994: F Lamballe; Richard J Smeyne; Mariano Barbacid
Developmental expression of trkC, the neurotrophin-3 receptor, in the mammalian nervous system.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1994;14(1):14-28.
1993: R Klein; Richard J Smeyne; W Wurst; L K Long; B A Auerbach; Alexandra L Joyner; Mariano Barbacid
Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death.
Cell 1993;75(1):113-22.
1993: H N Marsh; W K Scholz; F Lamballe; R Klein; V Nanduri; Mariano Barbacid; H Clive Palfrey
Signal transduction events mediated by the BDNF receptor gp 145trkB in primary hippocampal pyramidal cell culture.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1993;13(10):4281-92.
1993: K D Beck; F Lamballe; R Klein; Mariano Barbacid; P E Schauwecker; Tom McNeill; Caleb E Finch; F Hefti; J R Day
Induction of noncatalytic TrkB neurotrophin receptors during axonal sprouting in the adult hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1993;13(9):4001-14.
1993: K L Suen; Xose Bustelo; T Pawson; Mariano Barbacid
Molecular cloning of the mouse grb2 gene: differential interaction of the Grb2 adaptor protein with epidermal growth factor and nerve growth factor receptors.
Molecular and cellular biology 1993;13(9):5500-12.
1993: F Lamballe; P Tapley; Mariano Barbacid
trkC encodes multiple neurotrophin-3 receptors with distinct biological properties and substrate specificities.
The EMBO journal 1993;12(8):3083-94.
1993: Mariano Barbacid
Nerve growth factor: a tale of two receptors.
Oncogene 1993;8(8):2033-42.
1993: Teresa Steininger; B H Wainer; R Klein; Mariano Barbacid; H C Palfrey
High-affinity nerve growth factor receptor (Trk) immunoreactivity is localized in cholinergic neurons of the basal forebrain and striatum in the adult rat brain.
Brain research 1993;612(1-2):330-5.
1993: Xose Bustelo; S D Rubin; K L Suen; D Carrasco; Mariano Barbacid
Developmental expression of the vav protooncogene.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1993;4(4):297-308.
1993: Nancy Y Ip; Trevor N Stitt; P Tapley; R Klein; David J Glass; J Fandl; L A Greene; Mariano Barbacid; George D Yancopoulos
Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells.
Neuron 1993;10(2):137-49.
1992: S Jing; P Tapley; Mariano Barbacid
Nerve growth factor mediates signal transduction through trk homodimer receptors.
Neuron 1992;9(6):1067-79.
1992: Xose Bustelo; Mariano Barbacid
Tyrosine phosphorylation of the vav proto-oncogene product in activated B cells.
Science (New York, N.Y.) 1992;256(5060):1196-9.
1992: R Klein; F Lamballe; S Bryant; Mariano Barbacid
The trkB tyrosine protein kinase is a receptor for neurotrophin-4.
Neuron 1992;8(5):947-56.
1992: W C Liu; Mariano Barbacid; M Bulgar; J M Clark; A R Crosswell; L Dean; T W Doyle; P B Fernandes; Stella Huang; swam manne
10'-Desmethoxystreptonigrin, a novel analog of streptonigrin.
The Journal of antibiotics 1992;45(4):454-7.
1992: Xose Bustelo; J A Ledbetter; Mariano Barbacid
Product of vav proto-oncogene defines a new class of tyrosine protein kinase substrates.
Nature 1992;356(6364):68-71.
1992: D Pulido; Sonsoles Campuzano; T Koda; Juan Modolell; Mariano Barbacid
Dtrk, a Drosophila gene related to the trk family of neurotrophin receptors, encodes a novel class of neural cell adhesion molecule.
The EMBO journal 1992;11(2):391-404.
1992: P Tapley; F Lamballe; Mariano Barbacid
K252a is a selective inhibitor of the tyrosine protein kinase activity of the trk family of oncogenes and neurotrophin receptors.
Oncogene 1992;7(2):371-81.
1991: Mariano Barbacid; F Lamballe; D Pulido; R Klein
The trk family of tyrosine protein kinase receptors.
Biochimica et biophysica acta 1991;1072(2-3):115-27.
1991: F Lamballe; R Klein; Mariano Barbacid
trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3.
Cell 1991;66(5):967-79.
1991: R Klein; V Nanduri; S A Jing; F Lamballe; P Tapley; S Bryant; C Cordon-Cardo; K R Jones; Louis F Reichardt; Mariano Barbacid
The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3.
Cell 1991;66(2):395-403.
1991: R Klein; S Q Jing; V Nanduri; E O'Rourke; Mariano Barbacid
The trk proto-oncogene encodes a receptor for nerve growth factor.
Cell 1991;65(1):189-97.
1991: J Coppola; S Bryant; T Koda; D Conway; Mariano Barbacid
Mechanism of activation of the vav protooncogene.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1991;2(2):95-105.
1991: D S Garlick; S Sukumar; Mariano Barbacid; D Petit; P J Hamer; Irwin Leav; J A Lavecchio; K L Trimpe; W P Carney
Generation of monoclonal antibodies specific for ras p21 Glu-12 oncoproteins: detection in carcinogen-induced mammary carcinomas.
Hybridoma 1991;10(1):95-102.
1991: F Lamballe; R Klein; Mariano Barbacid
The trk family of oncogenes and neurotrophin receptors.
Princess Takamatsu symposia 1991;22():153-70.
1990: C Martinerie; Linda Cannizzaro; C M Croce; K Huebner; S Katzav; Mariano Barbacid
The human VAV proto-oncogene maps to chromosome region 19p12----19p13.2.
Human genetics 1990;86(1):65-8.
1990: R Kumar; Saraswati Sukumar; Mariano Barbacid
Activation of ras oncogenes preceding the onset of neoplasia.
Science (New York, N.Y.) 1990;248(4959):1101-4.
1990: Mariano Barbacid
ras oncogenes: their role in neoplasia.
European journal of clinical investigation 1990;20(3):225-35.
1990: R Klein; D Conway; Luis F Parada; Mariano Barbacid
The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain.
Cell 1990;61(4):647-56.
1989: R Klein; Luis F Parada; François Coulier; Mariano Barbacid
trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development.
The EMBO journal 1989;8(12):3701-9.
1989: S Katzav; D Martin-Zanca; Mariano Barbacid
vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells.
The EMBO journal 1989;8(8):2283-90.