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Mariano Barbacid

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Urosevic Jelena; Sum Eleanor Y M; Moneo Victoria; Drosten Matthias; Dhawahir Alma; Becerra Mercedes; Carnero Amancio; Barbacid Mariano
Using cells devoid of RAS proteins as tools for drug discovery.
Martínez-Romero Carles; Rooman Ilse; Skoudy Anouchka; Guerra Carmen; Molero Xavier; González Ana; Iglesias Mar; Lobato Tania; Bosch Almudena; Barbacid Mariano; Real Francisco X; Hernández-Muñoz Inmaculada
The epigenetic regulators Bmi1 and Ring1B are differentially regulated in pancreatitis and pancreatic ductal adenocarcinoma.
Malumbres Marcos; Barbacid Mariano
Cell cycle, CDKs and cancer: a changing paradigm.

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All Publications

2009: Urosevic Jelena; Sum Eleanor Y M; Moneo Victoria; Drosten Matthias; Dhawahir Alma; Becerra Mercedes; Carnero Amancio; Barbacid Mariano
Using cells devoid of RAS proteins as tools for drug discovery.
Molecular carcinogenesis 2009;48(11):1038-47.
2009: Martínez-Romero Carles; Rooman Ilse; Skoudy Anouchka; Guerra Carmen; Molero Xavier; González Ana; Iglesias Mar; Lobato Tania; Bosch Almudena; Barbacid Mariano; Real Francisco X; Hernández-Muñoz Inmaculada
The epigenetic regulators Bmi1 and Ring1B are differentially regulated in pancreatitis and pancreatic ductal adenocarcinoma.
The Journal of pathology 2009;219(2):205-13.
2009: Malumbres Marcos; Barbacid Mariano
Cell cycle, CDKs and cancer: a changing paradigm.
Nature reviews. Cancer 2009;9(3):153-66.
2008: Boyle P; Anderson B O; Andersson L C; Ariyaratne Y; Auleley G-R; Barbacid M; Bartelink H; Baselga J; Behbehani K; Belardelli F; Berns A; Bishop J; Brawley O; Burns H; Clanton M; Cox B; Currow D; Dangou J-M; de Valeriola D; Dinshaw K; Eggermont A; Fitzpatrick J; Forstmane M; Garaci E; Gavin A T; Kakizoe T; Kasler M; Keita N; Kerr D; Khayat D; Khleif S; Khuhaprema T; Knezevic T; Kubinova R; Mallath M; Martin-Moreno J; McCance D; McVie J G; Merriman A; Ngoma T; Nowacki M; Orgelbrand J; Park J-G; Pierotti M; Ashton L P; Puska P; Escobar C V R; Rajan B; Rajkumar T; Ringborg U; Robertson C; Rodger A; Roovali L; Santini L A; Sarhan M; Seffrin J; Semiglazov V; Shrestha B M; Soo K C; Stamenic V; Tamblyn C; Thomas R; Tuncer M; Tursz T; Vaitkiene R; Vallejos C; Veronesi U; Wojtyla A; Yach D; Yoo K-Y; Zatonski W; Zaridze D; Zeng Y-X; Zhao P; Zheng T
Need for global action for cancer control.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2008;19(9):1519-21.
2008: Schuhmacher Alberto J; Guerra Carmen; Sauzeau Vincent; Cañamero Marta; Bustelo Xosé R; Barbacid Mariano
A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition.
The Journal of clinical investigation 2008;118(6):2169-79.
2008: Atanasoski Suzana; Boentert Matthias; De Ventura Lukas; Pohl Hartmut; Baranek Constanze; Beier Konstantin; Young Peter; Barbacid Mariano; Suter Ueli
Postnatal Schwann cell proliferation but not myelination is strictly and uniquely dependent on cyclin-dependent kinase 4 (cdk4).
Molecular and cellular neurosciences 2008;37(3):519-27.
2008: Malumbres Marcos; Pevarello Paolo; Barbacid Mariano; Bischoff James R
CDK inhibitors in cancer therapy: what is next?
Trends in pharmacological sciences 2008;29(1):16-21.
2007: Santamaría David; Barrière Cédric; Cerqueira Antonio; Hunt Sarah; Tardy Claudine; Newton Kathryn; Cáceres Javier F; Dubus Pierre; Malumbres Marcos; Barbacid Mariano
Cdk1 is sufficient to drive the mammalian cell cycle.
Nature 2007;448(7155):811-5.
2007: Barrière Cédric; Santamaría David; Cerqueira Antonio; Galán Javier; Martín Alberto; Ortega Sagrario; Malumbres Marcos; Dubus Pierre; Barbacid Mariano
Mice thrive without Cdk4 and Cdk2.
Molecular oncology 2007;1(1):72-83.
2007: Ventura Juan José; Tenbaum Stephan; Perdiguero Eusebio; Huth Marion; Guerra Carmen; Barbacid Mariano; Pasparakis Manolis; Nebreda Angel R
p38alpha MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation.
Nature genetics 2007;39(6):750-8.
2007: Barbacid Mariano
Returning home.
Cell 2007;129(4):641-4.
2007: Guerra Carmen; Schuhmacher Alberto J; Cañamero Marta; Grippo Paul J; Verdaguer Lena; Pérez-Gallego Lucía; Dubus Pierre; Sandgren Eric P; Barbacid Mariano
Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice.
Cancer cell 2007;11(3):291-302.
2007: Malumbres Marcos; Barbacid Mariano
Cell cycle kinases in cancer.
Current opinion in genetics & development 2007;17(1):60-5.
2006: Sansom Owen J; Meniel Valerie; Wilkins Julie A; Cole Alicia M; Oien Karin A; Marsh Victoria; Jamieson Thomas J; Guerra Carmen; Ashton Gabrielle H; Barbacid Mariano; Clarke Alan R
Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(38):14122-7.
2006: Tormo Damia; Ferrer Aleix; Gaffal Evelyn; Wenzel Jörg; Basner-Tschakarjan Etiena; Steitz Julia; Heukamp Lukas C; Gütgemann Ines; Buettner Reinhard; Malumbres Marcos; Barbacid Mariano; Merlino Glenn; Tüting Thomas
Rapid growth of invasive metastatic melanoma in carcinogen-treated hepatocyte growth factor/scatter factor-transgenic mice carrying an oncogenic CDK4 mutation.
The American journal of pathology 2006;169(2):665-72.
2006: Duensing A; Liu Y; Tseng M; Malumbres M; Barbacid M; Duensing S
Cyclin-dependent kinase 2 is dispensable for normal centrosome duplication but required for oncogene-induced centrosome overduplication.
Oncogene 2006;25(20):2943-9.
2006: Hacker Elke; Muller H Konrad; Irwin Nicole; Gabrielli Brian; Lincoln Douglas; Pavey Sandra; Powell Marianne Broome; Malumbres Marcos; Barbacid Mariano; Hayward Nicholas; Walker Graeme
Spontaneous and UV radiation-induced multiple metastatic melanomas in Cdk4R24C/R24C/TPras mice.
Cancer research 2006;66(6):2946-52.
2006: Malumbres Marcos; Barbacid Mariano
Is Cyclin D1-CDK4 kinase a bona fide cancer target?
Cancer cell 2006;9(1):2-4.
2006: Steitz Julia; Büchs Stefanie; Tormo Damia; Ferrer Aleix; Wenzel Jörg; Huber Christoph; Wölfel Thomas; Barbacid Mariano; Malumbres Marcos; Tüting Thomas
Evaluation of genetic melanoma vaccines in cdk4-mutant mice provides evidence for immunological tolerance against authochthonous melanomas in the skin.
International journal of cancer. Journal international du cancer 2006;118(2):373-80.
2005: Malumbres Marcos; Barbacid Mariano
Mammalian cyclin-dependent kinases.
Trends in biochemical sciences 2005;30(11):630-41.
2005: Abella Anna; Dubus Pierre; Malumbres Marcos; Rane Sushil G; Kiyokawa Hiroaki; Sicard Audrey; Vignon Françoise; Langin Dominique; Barbacid Mariano; Fajas Lluis
Cdk4 promotes adipogenesis through PPARgamma activation.
Cell metabolism 2005;2(4):239-49.
2005: Collado Manuel; Gil Jesús; Efeyan Alejo; Guerra Carmen; Schuhmacher Alberto J; Barradas Marta; Benguría Alberto; Zaballos Angel; Flores Juana M; Barbacid Mariano; Beach David; Serrano Manuel
Tumour biology: senescence in premalignant tumours.
Nature 2005;436(7051):642.
2005: Martín Alberto; Odajima Junko; Hunt Sarah L; Dubus Pierre; Ortega Sagrario; Malumbres Marcos; Barbacid Mariano
Cdk2 is dispensable for cell cycle inhibition and tumor suppression mediated by p27(Kip1) and p21(Cip1).
Cancer cell 2005;7(6):591-8.
2005: Sotillo Rocío; Renner Oliver; Dubus Pierre; Ruiz-Cabello Jesús; Martín-Caballero Juan; Barbacid Mariano; Carnero Amancio; Malumbres Marcos
Cooperation between Cdk4 and p27kip1 in tumor development: a preclinical model to evaluate cell cycle inhibitors with therapeutic activity.
Cancer research 2005;65(9):3846-52.
2005: Mijimolle Nieves; Velasco Juan; Dubus Pierre; Guerra Carmen; Weinbaum Carolyn A; Casey Patrick J; Campuzano Victoria; Barbacid Mariano
Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development.
Cancer cell 2005;7(4):313-24.
2005: Barbacid M; Ortega S; Sotillo R; Odajima J; Martín A; Santamaría D; Dubus P; Malumbres M
Cell cycle and cancer: genetic analysis of the role of cyclin-dependent kinases.
Cold Spring Harbor symposia on quantitative biology 2005;70():233-40.
2004: Auwerx Johan; Avner Phil; Baldock Richard; Ballabio Andrea; Balling Rudi; Barbacid Mariano; Berns Anton; Bradley Allan; Brown Steve; Carmeliet Peter; Chambon Pierre; Cox Roger; Davidson Duncan; Davies Kay; Duboule Denis; Forejt Jiri; Granucci Francesca; Hastie Nick; de Angelis Martin Hrabé; Jackson Ian; Kioussis Dimitris; Kollias George; Lathrop Mark; Lendahl Urban; Malumbres Marcos; von Melchner Harald; Müller Werner; Partanen Juha; Ricciardi-Castagnoli Paola; Rigby Peter; Rosen Barry; Rosenthal Nadia; Skarnes Bill; Stewart A Francis; Thornton Janet; Tocchini-Valentini Glauco; Wagner Erwin; Wahli Walter; Wurst Wolfgang
The European dimension for the mouse genome mutagenesis program.
Nature genetics 2004;36(9):925-7.
2004: Malumbres Marcos; Sotillo Rocío; Santamaría David; Galán Javier; Cerezo Ana; Ortega Sagrario; Dubus Pierre; Barbacid Mariano
Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6.
Cell 2004;118(4):493-504.
2003: Ortega Sagrario; Prieto Ignacio; Odajima Junko; Martín Alberto; Dubus Pierre; Sotillo Rocio; Barbero Jose Luis; Malumbres Marcos; Barbacid Mariano
Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice.
Nature genetics 2003;35(1):25-31.
2003: Guerra Carmen; Mijimolle Nieves; Dhawahir Alma; Dubus Pierre; Barradas Marta; Serrano Manuel; Campuzano Victoria; Barbacid Mariano
Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context.
Cancer cell 2003;4(2):111-20.
2003: Martín Javier; Hunt Sarah L; Dubus Pierre; Sotillo Rocío; Néhmé-Pélluard Fanny; Magnuson Mark A; Parlow Albert F; Malumbres Marcos; Ortega Sagrario; Barbacid Mariano
Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number.
Oncogene 2003;22(34):5261-9.
2003: Malumbres Marcos; Barbacid Mariano
RAS oncogenes: the first 30 years.
Nature reviews. Cancer 2003;3(6):459-65.
2003: Malumbres Marcos; Hunt Sarah L; Sotillo Rocío; Martín Javier; Odajima Jun; Martín Alberto; Dubus Pierre; Ortega Sagrario; Barbacid Mariano
Driving the cell cycle to cancer.
Advances in experimental medicine and biology 2003;532():1-11.
2002: Ortega Sagrario; Malumbres Marcos; Barbacid Mariano
Cyclin D-dependent kinases, INK4 inhibitors and cancer.
Biochimica et biophysica acta 2002;1602(1):73-87.
2002: Barbacid Mariano
Mariano Barbacid: director of Spain's first national cancer centre. Interviewed by Adrian Burton.
The lancet oncology 2002;3(2):118-23.
2001: Malumbres M; Barbacid M
To cycle or not to cycle: a critical decision in cancer.
Nature reviews. Cancer 2001;1(3):222-31.
2001: Sotillo R; Dubus P; Martín J; de la Cueva E; Ortega S; Malumbres M; Barbacid M
Wide spectrum of tumors in knock-in mice carrying a Cdk4 protein insensitive to INK4 inhibitors.
The EMBO journal 2001;20(23):6637-47.
2001: Sotillo R; García J F; Ortega S; Martin J; Dubus P; Barbacid M; Malumbres M
Invasive melanoma in Cdk4-targeted mice.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(23):13312-7.
2001: Zindy F; den Besten W; Chen B; Rehg J E; Latres E; Barbacid M; Pollard J W; Sherr C J; Cohen P E; Roussel M F
Control of spermatogenesis in mice by the cyclin D-dependent kinase inhibitors p18(Ink4c) and p19(Ink4d).
Molecular and cellular biology 2001;21(9):3244-55.
2001: Matsuo S; Ichikawa H; Henderson T A; Silos-Santiago I; Barbacid M; Arends J J; Jacquin M F
trkA modulation of developing somatosensory neurons in oro-facial tissues: tooth pulp fibers are absent in trkA knockout mice.
Neuroscience 2001;105(3):747-60.
2000: Malumbres M; Ortega S; Barbacid M
Genetic analysis of mammalian cyclin-dependent kinases and their inhibitors.
Biological chemistry 2000;381(9-10):827-38.
2000: Latres E; Malumbres M; Sotillo R; Martín J; Ortega S; Martín-Caballero J; Flores J M; Cordón-Cardo C; Barbacid M
Limited overlapping roles of P15(INK4b) and P18(INK4c) cell cycle inhibitors in proliferation and tumorigenesis.
The EMBO journal 2000;19(13):3496-506.
2000: Feldheim D A; Kim Y I; Bergemann A D; Frisén J; Barbacid M; Flanagan J G
Genetic analysis of ephrin-A2 and ephrin-A5 shows their requirement in multiple aspects of retinocollicular mapping.
Neuron 2000;25(3):563-74.
1999: Frisén J; Holmberg J; Barbacid M
Ephrins and their Eph receptors: multitalented directors of embryonic development.
The EMBO journal 1999;18(19):5159-65.
1999: Rane S G; Dubus P; Mettus R V; Galbreath E J; Boden G; Reddy E P; Barbacid M
Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia.
Nature genetics 1999;22(1):44-52.
1998: Feldheim D A; Vanderhaeghen P; Hansen M J; Frisén J; Lu Q; Barbacid M; Flanagan J G
Topographic guidance labels in a sensory projection to the forebrain.
Neuron 1998;21(6):1303-13.
1998: Fritzsch B; Barbacid M; Silos-Santiago I
Nerve dependency of developing and mature sensory receptor cells.
Annals of the New York Academy of Sciences 1998;855():14-27.
1998: Fritzsch B; Barbacid M; Silos-Santiago I
The combined effects of trkB and trkC mutations on the innervation of the inner ear.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 1998;16(6):493-505.
1998: Martínez A; Alcántara S; Borrell V; Del Río J A; Blasi J; Otal R; Campos N; Boronat A; Barbacid M; Silos-Santiago I; Soriano E
TrkB and TrkC signaling are required for maturation and synaptogenesis of hippocampal connections.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(18):7336-50.
1998: Rice F L; Albers K M; Davis B M; Silos-Santiago I; Wilkinson G A; LeMaster A M; Ernfors P; Smeyne R J; Aldskogius H; Phillips H S; Barbacid M; DeChiara T M; Yancopoulos G D; Dunne C E; Fundin B T
Differential dependency of unmyelinated and A delta epidermal and upper dermal innervation on neurotrophins, trk receptors, and p75LNGFR.
Developmental biology 1998;198(1):57-81.
1998: Frisén J; Yates P A; McLaughlin T; Friedman G C; O'Leary D D; Barbacid M
Ephrin-A5 (AL-1/RAGS) is essential for proper retinal axon guidance and topographic mapping in the mammalian visual system.
Neuron 1998;20(2):235-43.
1998: de Castro F; Silos-Santiago I; López de Armentia M; Barbacid M; Belmonte C
Corneal innervation and sensitivity to noxious stimuli in trkA knockout mice.
The European journal of neuroscience 1998;10(1):146-52.
1997: Bustelo X R; Crespo P; López-Barahona M; Gutkind J S; Barbacid M
Cbl-b, a member of the Sli-1/c-Cbl protein family, inhibits Vav-mediated c-Jun N-terminal kinase activation.
Oncogene 1997;15(21):2511-20.
1997: Frisén J; Barbacid M
Genetic analysis of the role of Eph receptors in the development of the mammalian nervous system.
Cell and tissue research 1997;290(2):209-15.
1997: Silos-Santiago I; Fagan A M; Garber M; Fritzsch B; Barbacid M
Severe sensory deficits but normal CNS development in newborn mice lacking TrkB and TrkC tyrosine protein kinase receptors.
The European journal of neuroscience 1997;9(10):2045-56.
1997: Fundin B T; Silos-Santiago I; Ernfors P; Fagan A M; Aldskogius H; DeChiara T M; Phillips H S; Barbacid M; Yancopoulos G D; Rice F L
Differential dependency of cutaneous mechanoreceptors on neurotrophins, trk receptors, and P75 LNGFR.
Developmental biology 1997;190(1):94-116.
1997: Fagan A M; Garber M; Barbacid M; Silos-Santiago I; Holtzman D M
A role for TrkA during maturation of striatal and basal forebrain cholinergic neurons in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(20):7644-54.
1997: Fritzsch B; Sarai P A; Barbacid M; Silos-Santiago I
Mice with a targeted disruption of the neurotrophin receptor trkB lose their gustatory ganglion cells early but do develop taste buds.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 1997;15(4-5):563-76.
1997: Rosa J L; Barbacid M
A giant protein that stimulates guanine nucleotide exchange on ARF1 and Rab proteins forms a cytosolic ternary complex with clathrin and Hsp70.
Oncogene 1997;15(1):1-6.
1997: Park S; Frisén J; Barbacid M
Aberrant axonal projections in mice lacking EphA8 (Eek) tyrosine protein kinase receptors.
The EMBO journal 1997;16(11):3106-14.
1997: Alcántara S; Frisén J; del Río J A; Soriano E; Barbacid M; Silos-Santiago I
TrkB signaling is required for postnatal survival of CNS neurons and protects hippocampal and motor neurons from axotomy-induced cell death.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(10):3623-33.
1997: Yan Y; Frisén J; Lee M H; Massagué J; Barbacid M
Ablation of the CDK inhibitor p57Kip2 results in increased apoptosis and delayed differentiation during mouse development.
Genes & development 1997;11(8):973-83.
1996: Fagan A M; Zhang H; Landis S; Smeyne R J; Silos-Santiago I; Barbacid M
TrkA, but not TrkC, receptors are essential for survival of sympathetic neurons in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(19):6208-18.
1996: Rosa J L; Casaroli-Marano R P; Buckler A J; Vilaró S; Barbacid M
p619, a giant protein related to the chromosome condensation regulator RCC1, stimulates guanine nucleotide exchange on ARF1 and Rab proteins.
The EMBO journal 1996;15(16):4262-73.
1996: White F A; Silos-Santiago I; Molliver D C; Nishimura M; Phillips H; Barbacid M; Snider W D
Synchronous onset of NGF and TrkA survival dependence in developing dorsal root ganglia.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(15):4662-72.
1996: Crespo P; Bustelo X R; Aaronson D S; Coso O A; Lopez-Barahona M; Barbacid M; Gutkind J S
Rac-1 dependent stimulation of the JNK/SAPK signaling pathway by Vav.
Oncogene 1996;13(3):455-60.
1996: Schuebel K E; Bustelo X R; Nielsen D A; Song B J; Barbacid M; Goldman D; Lee I J
Isolation and characterization of murine vav2, a member of the vav family of proto-oncogenes.
Oncogene 1996;13(2):363-71.
1996: Sánchez M P; Silos-Santiago I; Frisén J; He B; Lira S A; Barbacid M
Renal agenesis and the absence of enteric neurons in mice lacking GDNF.
Nature 1996;382(6586):70-3.
1996: López-Barahona M; Bustelo X R; Barbacid M
The TC21 oncoprotein interacts with the Ral guanosine nucleotide dissociation factor.
Oncogene 1996;12(3):463-70.
1996: Leftheris K; Kline T; Vite G D; Cho Y H; Bhide R S; Patel D V; Patel M M; Schmidt R J; Weller H N; Andahazy M L; Carboni J M; Gullo-Brown J L; Lee F Y; Ricca C; Rose W C; Yan N; Barbacid M; Hunt J T; Meyers C A; Seizinger B R; Zahler R; Manne V
Development of highly potent inhibitors of Ras farnesyltransferase possessing cellular and in vivo activity.
Journal of medicinal chemistry 1996;39(1):224-36.
1995: Suen K L; Bustelo X R; Barbacid M
Lack of evidence for the activation of the Ras/Raf mitogenic pathway by 14-3-3 proteins in mammalian cells.
Oncogene 1995;11(5):825-31.
1995: Silos-Santiago I; Molliver D C; Ozaki S; Smeyne R J; Fagan A M; Barbacid M; Snider W D
Non-TrkA-expressing small DRG neurons are lost in TrkA deficient mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(9):5929-42.
1995: Barbacid M
Structural and functional properties of the TRK family of neurotrophin receptors.
Annals of the New York Academy of Sciences 1995;766():442-58.
1995: Carboni J M; Yan N; Cox A D; Bustelo X; Graham S M; Lynch M J; Weinmann R; Seizinger B R; Der C J; Barbacid M
Farnesyltransferase inhibitors are inhibitors of Ras but not R-Ras2/TC21, transformation.
Oncogene 1995;10(10):1905-13.
1995: Barbacid M
Neurotrophic factors and their receptors.
Current opinion in cell biology 1995;7(2):148-55.
1995: Bustelo X R; Suen K L; Michael W M; Dreyfuss G; Barbacid M
Association of the vav proto-oncogene product with poly(rC)-specific RNA-binding proteins.
Molecular and cellular biology 1995;15(3):1324-32.
1995: Patel D V; Gordon E M; Schmidt R J; Weller H N; Young M G; Zahler R; Barbacid M; Carboni J M; Gullo-Brown J L; Hunihan L
Phosphinyl acid-based bisubstrate analog inhibitors of Ras farnesyl protein transferase.
Journal of medicinal chemistry 1995;38(3):435-42.
1995: Zmuidzinas A; Fischer K D; Lira S A; Forrester L; Bryant S; Bernstein A; Barbacid M
The vav proto-oncogene is required early in embryogenesis but not for hematopoietic development in vitro.
The EMBO journal 1995;14(1):1-11.
1994: Wittekind M; Mapelli C; Farmer B T; Suen K L; Goldfarb V; Tsao J; Lavoie T; Barbacid M; Meyers C A; Mueller L
Orientation of peptide fragments from Sos proteins bound to the N-terminal SH3 domain of Grb2 determined by NMR spectroscopy.
Biochemistry 1994;33(46):13531-9.
1994: Barbacid M
The Trk family of neurotrophin receptors.
Journal of neurobiology 1994;25(11):1386-403.
1994: Bustelo X R; Suen K L; Leftheris K; Meyers C A; Barbacid M
Vav cooperates with Ras to transform rodent fibroblasts but is not a Ras GDP/GTP exchange factor.
Oncogene 1994;9(8):2405-13.
1994: Klein R; Silos-Santiago I; Smeyne R J; Lira S A; Brambilla R; Bryant S; Zhang L; Snider W D; Barbacid M
Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements.
Nature 1994;368(6468):249-51.
1994: Smeyne R J; Klein R; Schnapp A; Long L K; Bryant S; Lewin A; Lira S A; Barbacid M
Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene.
Nature 1994;368(6468):246-9.
1994: Sánchez M P; Tapley P; Saini S S; He B; Pulido D; Barbacid M
Multiple tyrosine protein kinases in rat hippocampal neurons: isolation of Ptk-3, a receptor expressed in proliferative zones of the developing brain.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(5):1819-23.
1994: Zhu X; Suen K L; Barbacid M; Bolen J B; Fargnoli J
Interleukin-2-induced tyrosine phosphorylation of Shc proteins correlates with factor-dependent T cell proliferation.
The Journal of biological chemistry 1994;269(8):5518-22.
1994: Lamballe F; Smeyne R J; Barbacid M
Developmental expression of trkC, the neurotrophin-3 receptor, in the mammalian nervous system.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1994;14(1):14-28.
1993: Marsh H N; Scholz W K; Lamballe F; Klein R; Nanduri V; Barbacid M; Palfrey H C
Signal transduction events mediated by the BDNF receptor gp 145trkB in primary hippocampal pyramidal cell culture.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1993;13(10):4281-92.
1993: Klein R; Smeyne R J; Wurst W; Long L K; Auerbach B A; Joyner A L; Barbacid M
Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death.
Cell 1993;75(1):113-22.
1993: Beck K D; Lamballe F; Klein R; Barbacid M; Schauwecker P E; McNeill T H; Finch C E; Hefti F; Day J R
Induction of noncatalytic TrkB neurotrophin receptors during axonal sprouting in the adult hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1993;13(9):4001-14.
1993: Suen K L; Bustelo X R; Pawson T; Barbacid M
Molecular cloning of the mouse grb2 gene: differential interaction of the Grb2 adaptor protein with epidermal growth factor and nerve growth factor receptors.
Molecular and cellular biology 1993;13(9):5500-12.
1993: Lamballe F; Tapley P; Barbacid M
trkC encodes multiple neurotrophin-3 receptors with distinct biological properties and substrate specificities.
The EMBO journal 1993;12(8):3083-94.
1993: Barbacid M
Nerve growth factor: a tale of two receptors.
Oncogene 1993;8(8):2033-42.
1993: Steininger T L; Wainer B H; Klein R; Barbacid M; Palfrey H C
High-affinity nerve growth factor receptor (Trk) immunoreactivity is localized in cholinergic neurons of the basal forebrain and striatum in the adult rat brain.
Brain research 1993;612(1-2):330-5.
1993: Bustelo X R; Rubin S D; Suen K L; Carrasco D; Barbacid M
Developmental expression of the vav protooncogene.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1993;4(4):297-308.
1993: Ip N Y; Stitt T N; Tapley P; Klein R; Glass D J; Fandl J; Greene L A; Barbacid M; Yancopoulos G D
Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells.
Neuron 1993;10(2):137-49.
1992: Jing S; Tapley P; Barbacid M
Nerve growth factor mediates signal transduction through trk homodimer receptors.
Neuron 1992;9(6):1067-79.
1992: Bustelo X R; Barbacid M
Tyrosine phosphorylation of the vav proto-oncogene product in activated B cells.
Science (New York, N.Y.) 1992;256(5060):1196-9.
1992: Klein R; Lamballe F; Bryant S; Barbacid M
The trkB tyrosine protein kinase is a receptor for neurotrophin-4.
Neuron 1992;8(5):947-56.
1992: Liu W C; Barbacid M; Bulgar M; Clark J M; Crosswell A R; Dean L; Doyle T W; Fernandes P B; Huang S; Manne V
10'-Desmethoxystreptonigrin, a novel analog of streptonigrin.
The Journal of antibiotics 1992;45(4):454-7.
1992: Bustelo X R; Ledbetter J A; Barbacid M
Product of vav proto-oncogene defines a new class of tyrosine protein kinase substrates.
Nature 1992;356(6364):68-71.
1992: Pulido D; Campuzano S; Koda T; Modolell J; Barbacid M
Dtrk, a Drosophila gene related to the trk family of neurotrophin receptors, encodes a novel class of neural cell adhesion molecule.
The EMBO journal 1992;11(2):391-404.
1992: Tapley P; Lamballe F; Barbacid M
K252a is a selective inhibitor of the tyrosine protein kinase activity of the trk family of oncogenes and neurotrophin receptors.
Oncogene 1992;7(2):371-81.
1991: Barbacid M; Lamballe F; Pulido D; Klein R
The trk family of tyrosine protein kinase receptors.
Biochimica et biophysica acta 1991;1072(2-3):115-27.
1991: Lamballe F; Klein R; Barbacid M
trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3.
Cell 1991;66(5):967-79.
1991: Klein R; Nanduri V; Jing S A; Lamballe F; Tapley P; Bryant S; Cordon-Cardo C; Jones K R; Reichardt L F; Barbacid M
The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3.
Cell 1991;66(2):395-403.
1991: Klein R; Jing S Q; Nanduri V; O'Rourke E; Barbacid M
The trk proto-oncogene encodes a receptor for nerve growth factor.
Cell 1991;65(1):189-97.
1991: Coppola J; Bryant S; Koda T; Conway D; Barbacid M
Mechanism of activation of the vav protooncogene.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1991;2(2):95-105.
1991: Garlick D S; Sukumar S; Barbacid M; Petit D; Hamer P J; Leav I; Lavecchio J A; Trimpe K L; Carney W P
Generation of monoclonal antibodies specific for ras p21 Glu-12 oncoproteins: detection in carcinogen-induced mammary carcinomas.
Hybridoma 1991;10(1):95-102.
1991: Lamballe F; Klein R; Barbacid M
The trk family of oncogenes and neurotrophin receptors.
Princess Takamatsu symposia 1991;22():153-70.
1990: Martinerie C; Cannizzaro L A; Croce C M; Huebner K; Katzav S; Barbacid M
The human VAV proto-oncogene maps to chromosome region 19p12----19p13.2.
Human genetics 1990;86(1):65-8.
1990: Kumar R; Sukumar S; Barbacid M
Activation of ras oncogenes preceding the onset of neoplasia.
Science (New York, N.Y.) 1990;248(4959):1101-4.
1990: Barbacid M
ras oncogenes: their role in neoplasia.
European journal of clinical investigation 1990;20(3):225-35.
1990: Klein R; Conway D; Parada L F; Barbacid M
The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain.
Cell 1990;61(4):647-56.
1989: Klein R; Parada L F; Coulier F; Barbacid M
trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development.
The EMBO journal 1989;8(12):3701-9.
1989: Katzav S; Martin-Zanca D; Barbacid M
vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells.
The EMBO journal 1989;8(8):2283-90.

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