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Alan Leff

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Co-Publications
Name
47
Munoz, Nilda
33
Zhu, Xiangdong
32
Muñoz, Nilda
27
Mitchell, Richard
25
White, Steven
21
Boetticher, Evan
19
Meliton, Angelo
17
Murphy, Thomas
16
Solway, Julian
13
Lambertino, Anissa
13
Rabe, Klaus
12
Myou, Shigeharu
11
Cho, Wonhwa
11
Hamann, Kimm
9
Myo, Saori

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Publications

TOP 3
Muñoz Nilda M; Meliton Angelo Y; Meliton Lucille N; Dudek Steven M; Leff Alan R
Secretory group V phospholipase A2 regulates acute lung injury and neutrophilic inflammation caused by LPS in mice.
Zhu Xiangdong; Boetticher Evan; Wang Lin; Duan Yingli; Learoyd Jonathan; Leff Alan R
Proline-rich tyrosine kinase 2 regulates spreading and migration of eosinophils after beta2-integrin adhesion.
Meliton Angelo Y; Munoz Nilda M; Zhu Xiangdong; Leff Alan R
Attenuated translocation of group IVa phospholipase A2 and up-regulated annexin-1 synthesis by glucocorticoid blocks beta 2-integrin adhesion in neutrophils.

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All Publications

2009: Muñoz Nilda M; Meliton Angelo Y; Meliton Lucille N; Dudek Steven M; Leff Alan R
Secretory group V phospholipase A2 regulates acute lung injury and neutrophilic inflammation caused by LPS in mice.
American journal of physiology. Lung cellular and molecular physiology 2009;296(6):L879-87.
2008: Zhu Xiangdong; Boetticher Evan; Wang Lin; Duan Yingli; Learoyd Jonathan; Leff Alan R
Proline-rich tyrosine kinase 2 regulates spreading and migration of eosinophils after beta2-integrin adhesion.
American journal of respiratory cell and molecular biology 2008;39(3):263-9.
2008: Meliton Angelo Y; Munoz Nilda M; Zhu Xiangdong; Leff Alan R
Attenuated translocation of group IVa phospholipase A2 and up-regulated annexin-1 synthesis by glucocorticoid blocks beta 2-integrin adhesion in neutrophils.
Journal of leukocyte biology 2008;83(2):344-51.
2007: Leff Alan R; Muñoz Nilda M
Future treatment to lessen exacerbations of chronic obstructive pulmonary disease.
Proceedings of the American Thoracic Society 2007;4(8):659-66.
2007: Meliton Angelo Y; Munoz Nilda M; Leff Alan R
Blockade of avidity and focal clustering of beta 2-integrin by cysteinyl leukotriene antagonism attenuates eosinophil adhesion.
The Journal of allergy and clinical immunology 2007;120(6):1316-23.
2007: Muñoz Nilda M; Meliton Angelo Y; Arm Jonathan P; Bonventre Joseph V; Cho Wonhwa; Leff Alan R
Deletion of secretory group V phospholipase A2 attenuates cell migration and airway hyperresponsiveness in immunosensitized mice.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(7):4800-7.
2007: Zhu Xiangdong; Learoyd Jonathan; Butt Sanober; Zhu Lilly; Usatyuk Peter V; Natarajan Viswanathan; Munoz Nilda M; Leff Alan R
Regulation of eosinophil adhesion by lysophosphatidylcholine via a non-store-operated Ca2+ channel.
American journal of respiratory cell and molecular biology 2007;36(5):585-93.
2007: Zhao Yutong; He Donghong; Zhao Jing; Wang Lixin; Leff Alan R; Spannhake Ernst Wm; Georas Steve; Natarajan Viswanathan
Lysophosphatidic acid induces interleukin-13 (IL-13) receptor alpha2 expression and inhibits IL-13 signaling in primary human bronchial epithelial cells.
The Journal of biological chemistry 2007;282(14):10172-9.
2006: Meliton A Y; Muñoz N M; Lambertino A; Boetticher E; Learoyd J; Zhu X; Leff A R
Phosphodiesterase 4 inhibition of beta2-integrin adhesion caused by leukotriene B4 and TNF-alpha in human neutrophils.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2006;28(5):920-8.
2006: Muñoz Nilda M; Meliton Angelo Y; Lambertino Anissa; Boetticher Evan; Learoyd Jonathan; Sultan Faraz; Zhu Xiangdong; Cho Wonhwa; Leff Alan R
Transcellular secretion of group V phospholipase A2 from epithelium induces beta 2-integrin-mediated adhesion and synthesis of leukotriene C4 in eosinophils.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(1):574-82.
2006: Munoz Nilda M; Leff Alan R
Highly purified selective isolation of eosinophils from human peripheral blood by negative immunomagnetic selection.
Nature protocols 2006;1(6):2613-20.
2005: Sano Masaaki; Leff Alan R; Myou Shigeharu; Boetticher Evan; Meliton Angelo Y; Learoyd Jonathan; Lambertino Anissa T; Munoz Nilda M; Zhu Xiangdong
Regulation of interleukin-5-induced beta2-integrin adhesion of human eosinophils by phosphoinositide 3-kinase.
American journal of respiratory cell and molecular biology 2005;33(1):65-70.
2005: Liu Jie; Zhu Xiangdong; Myo Saori; Lambertino Anissa T; Xu Chang; Boetticher Evan; Muñoz Nilda M; Sano Masaaki; Cordoba Martha; Learoyd Jonathan; Meliton Angelo; Johnson Malcolm; Leff Alan R
Glucocorticoid-induced surface expression of annexin 1 blocks beta2-integrin adhesion of human eosinophils to intercellular adhesion molecule 1 surrogate protein.
The Journal of allergy and clinical immunology 2005;115(3):493-500.
2004: Danek Christopher J; Lombard Charles M; Dungworth Donald L; Cox P Gerard; Miller John D; Biggs Michael J; Keast Thomas M; Loomas Bryan E; Wizeman William J; Hogg James C; Leff Alan R
Reduction in airway hyperresponsiveness to methacholine by the application of RF energy in dogs.
Journal of applied physiology (Bethesda, Md. : 1985) 2004;97(5):1946-53.
2004: Cox P G; Miller J; Mitzner W; Leff A R
Radiofrequency ablation of airway smooth muscle for sustained treatment of asthma: preliminary investigations.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2004;24(4):659-63.
2004: Myo S; Zhu X; Myou S; Meliton A Y; Liu J; Boetticher E; Lambertino A T; Xu C; Muñoz N M; Leff A R
Additive blockade of beta 2-integrin adhesion of eosinophils by salmeterol and fluticasone propionate.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2004;23(4):511-7.
2004: Liu Jie; Muñoz Nilda M; Meliton Angelo Y; Zhu Xiangdong; Lambertino Anissa T; Xu Chang; Myo Saori; Myou Shigeharu; Boetticher Evan; Johnson Malcolm; Leff Alan R
Beta2-integrin adhesion caused by eotaxin but not IL-5 is blocked by PDE-4 inhibition and beta2-adrenoceptor activation in human eosinophils.
Pulmonary pharmacology & therapeutics 2004;17(2):73-9.
2003: Myou Shigeharu; Leff Alan R; Myo Saori; Boetticher Evan; Tong Jiankun; Meliton Angelo Y; Liu Jie; Munoz Nilda M; Zhu Xiangdong
Blockade of inflammation and airway hyperresponsiveness in immune-sensitized mice by dominant-negative phosphoinositide 3-kinase-TAT.
The Journal of experimental medicine 2003;198(10):1573-82.
2003: Myou Shigeharu; Leff Alan R; Myo Saori; Boetticher Evan; Meliton Angelo Y; Lambertino Anissa T; Liu Jie; Xu Chang; Munoz Nilda M; Zhu Xiangdong
Activation of group IV cytosolic phospholipase A2 in human eosinophils by phosphoinositide 3-kinase through a mitogen-activated protein kinase-independent pathway.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(8):4399-405.
2003: Myou Shigeharu; Zhu Xiangdong; Myo Saori; Boetticher Evan; Meliton Angelo Y; Liu Jie; Munoz Nilda M; Leff Alan R
Blockade of airway inflammation and hyperresponsiveness by HIV-TAT-dominant negative Ras.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(8):4379-84.
2003: Zhu Xiangdong; Lambertino Anissa T; Houghton Tom J; McGilvra Jeff D; Xu Chang; Rawal Viresh H; Leff Alan R
Structural determinants of blockade of eosinophil activation, adhesion and secretion by synthetic analogs of phomactin.
Life sciences 2003;73(23):3005-16.
2003: Muñoz Nilda M; Kim Young Jun; Meliton Angelo Y; Kim Kwang Pyo; Han Sang-Kyou; Boetticher Evan; O'Leary Eileen; Myou Shigeharu; Zhu Xiangdong; Bonventre Joseph V; Leff Alan R; Cho Wonhwa
Human group V phospholipase A2 induces group IVA phospholipase A2-independent cysteinyl leukotriene synthesis in human eosinophils.
The Journal of biological chemistry 2003;278(40):38813-20.
2003: Meliton Angelo Y; Muñoz Nilda M; Liu Jie; Lambertino Anissa T; Boetticher Evan; Myo Saori; Myou Shigeharu; Zhu Xiangdong; Johnson Malcolm; Leff Alan R
Blockade of LTC4 synthesis caused by additive inhibition of gIV-PLA2 phosphorylation: Effect of salmeterol and PDE4 inhibition in human eosinophils.
The Journal of allergy and clinical immunology 2003;112(2):404-10.
2003: Noth Imre; Strek Mary E; Leff Alan R
Churg-Strauss syndrome.
Lancet 2003;361(9357):587-94.
2002: Zhu Xiangdong; Jacobs Benjamin; Boetticher Evan; Myou Shigeharu; Meliton Angelo; Sano Hiroyuki; Lambertino Anissa T; Muñoz Nilda M; Leff Alan R
IL-5-induced integrin adhesion of human eosinophils caused by ERK1/2-mediated activation of cPLA2.
Journal of leukocyte biology 2002;72(5):1046-53.
2002: Myou Shigeharu; Zhu Xiangdong; Boetticher Evan; Qin Yimin; Myo Saori; Meliton Angelo; Lambertino Anissa; Munoz Nilda M; Hamann Kimm J; Leff Alan R
Regulation of adhesion of AML14.3D10 cells by surface clustering of beta2-integrin caused by ERK-independent activation of cPLA2.
Immunology 2002;107(1):77-85.
2002: Myou Shigeharu; Zhu Xiangdong; Boetticher Evan; Myo Saori; Meliton Angelo; Lambertino Anissa; Munoz Nilda M; Leff Alan R
Blockade of focal clustering and active conformation in beta 2-integrin-mediated adhesion of eosinophils to intercellular adhesion molecule-1 caused by transduction of HIV TAT-dominant negative Ras.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(5):2670-6.
2002: Kim Young Jun; Kim Kwang Pyo; Han Sang Kyou; Munoz Nilda M; Zhu Xiangdong; Sano Hiroyuki; Leff Alan R; Cho Wonhwa
Group V phospholipase A2 induces leukotriene biosynthesis in human neutrophils through the activation of group IVA phospholipase A2.
The Journal of biological chemistry 2002;277(39):36479-88.
2002: Schmidt D T; Dent G; Rühlmann E; Muñoz N M; Leff A R; Rabe K F
Studying human airway pharmacology in microsections: application of videomicrometry.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2002;19(6):991-6.
2002: Muñoz Nilda M; Boetticher Evan; Sperling Anne I; Kim Kwang-Pyo; Meliton Angelo Y; Zhu Xiangdong; Lambertino Anissa; Cho Wonhwa; Leff Alan R
Quantitation of secretory group V phospholipase A(2) in human tissues by sandwich enzyme-linked immunosorbent assay.
Journal of immunological methods 2002;262(1-2):41-51.
2001: Sano A; Zhu X; Sano H; Muñoz N M; Boetticher E; Leff A R
Regulation of eosinophil function by phosphatidylinositol-specific PLC and cytosolic PLA(2).
American journal of physiology. Lung cellular and molecular physiology 2001;281(4):L844-51.
2001: Zhu X; Sano H; Kim K P; Sano A; Boetticher E; Muñoz N M; Cho W; Leff A R
Role of mitogen-activated protein kinase-mediated cytosolic phospholipase A2 activation in arachidonic acid metabolism in human eosinophils.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(1):461-8.
2001: Leff A R;
Discovery of leukotrienes and development of antileukotriene agents.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2001;86(6 Suppl 1):4-8.
2001: Leff A R
The Antileukotriene Working Group consensus conference overview.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2001;86(6 Suppl 1):1-3.
2001: Kim K P; Rafter J D; Bittova L; Han S K; Snitko Y; Munoz N M; Leff A R; Cho W
Mechanism of human group V phospholipase A2 (PLA2)-induced leukotriene biosynthesis in human neutrophils. A potential role of heparan sulfate binding in PLA2 internalization and degradation.
The Journal of biological chemistry 2001;276(14):11126-34.
2001: Sano H; Zhu X; Sano A; Boetticher E E; Shioya T; Jacobs B; Munoz N M; Leff A R
Extracellular signal-regulated kinase 1/2-mediated phosphorylation of cytosolic phospholipase A2 is essential for human eosinophil adhesion to fibronectin.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(5):3515-21.
2001: Myou S; Sano H; Fujimura M; Zhu X; Kurashima K; Kita T; Nakao S; Nonomura A; Shioya T; Kim K P; Munoz N M; Cho W; Leff A R
Blockade of eosinophil migration and airway hyperresponsiveness by cPLA2-inhibition.
Nature immunology 2001;2(2):145-9.
2001: Leff A R
Regulation of leukotrienes in the management of asthma: biology and clinical therapy.
Annual review of medicine 2001;52():1-14.
2000: Leff A R
Role of leukotrienes in bronchial hyperresponsiveness and cellular responses in airways.
Thorax 2000;55 Suppl 2():S32-7.
2000: Dent G; Munoz N M; Zhu X; Rühlmann E; Magnussen H; Leff A R; Rabe K F
Involvement of protein tyrosine kinases in activation of human eosinophils by platelet-activating factor.
Immunology 2000;100(2):231-7.
2000: Zhu X; Subbaraman R; Sano H; Jacobs B; Sano A; Boetticher E; Muñoz N M; Leff A R
A surrogate method for assessment of beta(2)-integrin-dependent adhesion of human eosinophils to ICAM-1.
Journal of immunological methods 2000;240(1-2):157-64.
2000: Muñoz N M; van Seventer G A; Semnani R T; Leff A R
Augmentation of LTC(4) synthesis in human eosinophils caused by CD3-stimulated Th2-like cells in vitro.
American journal of physiology. Lung cellular and molecular physiology 2000;278(6):L1172-9.
2000: Muñoz N M; Kim K P; Han S K; Boetticher E; Sperling A I; Sano H; Zhu X; Cho W; Leff A R
Characterization of monoclonal antibodies specific for 14-kDa human group V secretory phospholipase A2 (hVPLA2).
Hybridoma 2000;19(2):171-6.
2000: Douglas I S; Leff A R; Sperling A I
CD4+ T cell and eosinophil adhesion is mediated by specific ICAM-3 ligation and results in eosinophil activation.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(6):3385-91.
2000: Leff A R
Role of leukotrienes in bronchial hyperresponsiveness and cellular responses in airways.
American journal of respiratory and critical care medicine 2000;161(2 Pt 2):S125-32.
1999: Ndukwu I M; Naureckas E T; Maxwell C; Waldman M; Leff A R
Relationship of cellular transmigration and airway response after allergen challenge.
American journal of respiratory and critical care medicine 1999;160(5 Pt 1):1516-24.
1999: Muñoz N M; Hamann K J; Rabe K F; Sano H; Zhu X; Leff A R
Augmentation of eosinophil degranulation and LTC(4) secretion by integrin-mediated endothelial cell adhesion.
The American journal of physiology 1999;277(4 Pt 1):L802-10.
1999: Zhu X; Muñoz N M; Kim K P; Sano H; Cho W; Leff A R
Cytosolic phospholipase A2 activation is essential for beta 1 and beta 2 integrin-dependent adhesion of human eosinophils.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(6):3423-9.
1999: Sano A; Muñoz N M; Sano H; Choi J; Zhu X; Jacobs B; Leff A R
Inhibition of cPLA2 translocation and leukotriene C4 secretion by fluticasone propionate in exogenously activated human eosinophils.
American journal of respiratory and critical care medicine 1999;159(6):1903-9.
1999: Carson S S; Bach P B; Brzozowski L; Leff A
Outcomes after long-term acute care. An analysis of 133 mechanically ventilated patients.
American journal of respiratory and critical care medicine 1999;159(5 Pt 1):1568-73.
1999: Han S K; Kim K P; Koduri R; Bittova L; Munoz N M; Leff A R; Wilton D C; Gelb M H; Cho W
Roles of Trp31 in high membrane binding and proinflammatory activity of human group V phospholipase A2.
The Journal of biological chemistry 1999;274(17):11881-8.
1999: Sano H; Muñoz N M; Sano A; Zhu X; Herrnreiter A; Choi J; Leff A R
Upregulated surface expression of intracellularly sequestered Igepsilon receptors (FcepsilonRII/CD23) following activation in human peripheral blood eosinophils.
Proceedings of the Association of American Physicians 1999;111(1):82-91.
1998: Leff A R
Biology of airway smooth muscle. Conference summary.
American journal of respiratory and critical care medicine 1998;158(5 Pt 3):S78-9.
1998: Bach P B; Carson S S; Leff A
Outcomes and resource utilization for patients with prolonged critical illness managed by university-based or community-based subspecialists.
American journal of respiratory and critical care medicine 1998;158(5 Pt 1):1410-5.
1998: Zhu X; Hamann K J; Muñoz N M; Rubio N; Mayer D; Hernrreiter A; Leff A R
Intracellular expression of Fc gamma RIII (CD16) and its mobilization by chemoattractants in human eosinophils.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(5):2574-9.
1998: Mitchell R W; Cozzi P; Ndukwu I M; Spaethe S; Leff A R; Padrid P A
Differential effects of cyclosporine A after acute antigen challenge in sensitized cats in vivo and ex vivo.
British journal of pharmacology 1998;123(6):1198-204.
1998: Dent G; White S R; Tenor H; Bodtke K; Schudt C; Leff A R; Magnussen H; Rabe K F
Cyclic nucleotide phosphodiesterase in human bronchial epithelial cells: characterization of isoenzymes and functional effects of PDE inhibitors.
Pulmonary pharmacology & therapeutics 1998;11(1):47-56.
1998: Leff A R
Pharmacologic management of asthma.
The Journal of allergy and clinical immunology 1998;101(2 Pt 2):S397-9.
1998: Dent G; Muñoz N M; Rühlmann E; Zhu X; Leff A R; Magnussen H; Rabe K F
Protein kinase C inhibition enhances platelet-activating factor-induced eicosanoid production in human eosinophils.
American journal of respiratory cell and molecular biology 1998;18(1):136-44.
1997: Garland A; Necheles J; White S R; Neeley S P; Leff A R; Carson S S; Alger L E; McAllister K; Solway J
Activated eosinophils elicit substance P release from cultured dorsal root ganglion neurons.
The American journal of physiology 1997;273(5 Pt 1):L1096-102.
1997: Heuertz R M; Hamann K J; Hershenson M B; Leff A R
Adhesion of bovine airway smooth muscle cells activates extracellular signal-regulated kinases.
American journal of respiratory cell and molecular biology 1997;17(4):456-61.
1997: Mitchell R W; Rabe K F; Magnussen H; Leff A R
Passive sensitization of human airways induces myogenic contractile responses in vitro.
Journal of applied physiology (Bethesda, Md. : 1985) 1997;83(4):1276-81.
1997: Ndukwu I M; White S R; Leff A R; Mitchell R W
EP1 receptor blockade attenuates both spontaneous tone and PGE2-elicited contraction in guinea pig trachealis.
The American journal of physiology 1997;273(3 Pt 1):L626-33.
1997: Palmer J S; Cromie W J; Plzak L F; Leff A R
A platelet activating factor antagonist attenuates the effects of testicular ischemia.
The Journal of urology 1997;158(3 Pt 2):1186-90.
1997: Saito M; Sato R; Muñoz N M; Herrnreiter A; Oyaizu M; Kasugai H; Narahashi T; Leff A R
Association of granular exocytosis with Ca(2+)-activated K+ channels in human eosinophils.
The American journal of physiology 1997;273(1 Pt 1):L16-21.
1997: Mitchell R W; Ndukwu I M; Leff A R; Padrid P A
Muscarinic hyperresponsiveness of antigen-sensitized feline airway smooth muscle in vitro.
American journal of veterinary research 1997;58(6):672-6.
1997: Muñoz N M; Douglas I; Mayer D; Herrnreiter A; Zhu X; Leff A R
Eosinophil chemotaxis inhibited by 5-lipoxygenase blockade and leukotriene receptor antagonism.
American journal of respiratory and critical care medicine 1997;155(4):1398-403.
1997: Mitchell R W; Rühlmann E; Magnussen H; Muñoz N M; Leff A R; Rabe K F
Conservation of bronchiolar wall area during constriction and dilation of human airways.
Journal of applied physiology (Bethesda, Md. : 1985) 1997;82(3):954-8.
1997: Leff A R
Future directions in asthma therapy. Is a cure possible?
Chest 1997;111(2 Suppl):61S-68S.
1997: Leff A R; Herrnreiter A; Naclerio R M; Baroody F M; Handley D A; Muñoz N M
Effect of enantiomeric forms of albuterol on stimulated secretion of granular protein from human eosinophils.
Pulmonary pharmacology & therapeutics 1997;10(2):97-104.
1996: Zhu X; Muñoz N M; Rubio N; Herrnreiter A; Mayer D; Douglas I; Leff A R
Quantitation of the cytosolic phospholipase A2 (type IV) in isolated human peripheral blood eosinophils by sandwich-ELISA.
Journal of immunological methods 1996;199(2):119-26.
1996: Padrid P A; Cozzi P; Leff A R
Cyclosporine A inhibits airway reactivity and remodeling after chronic antigen challenge in cats.
American journal of respiratory and critical care medicine 1996;154(6 Pt 1):1812-8.
1996: Hamann K J; Neeley S P; Dowling T L; Grant J A; Leff A R
Effect of interleukin-5 exposure during in vitro eosinophilopiesis on MAC-1 adhesion molecule expression and function on cultured human eosinophils.
Blood 1996;88(9):3575-82.
1996: Muñoz N M; Rabe K F; Neeley S P; Herrnreiter A; Zhu X; McAllister K; Mayer D; Magnussen H; Galens S; Leff A R
Eosinophil VLA-4 binding to fibronectin augments bronchial narrowing through 5-lipoxygenase activation.
The American journal of physiology 1996;270(4 Pt 1):L587-94.
1996: Strek M E; Williams F S; Gleich G J; Leff A R; White S R
Mechanisms of smooth muscle contraction elicited by cationic proteins in guinea pig trachealis.
The American journal of physiology 1996;270(1 Pt 1):L133-40.
1995: Mitchell R W; Ndukwu I M; Herrnreiter A; Uzendoski K; Gitter B; Solway J; Leff A R
Differential tachykinin receptor subtype activation in capsaicin and KCl contractions of guinea pig trachealis.
The American journal of physiology 1995;269(6 Pt 1):L837-42.
1995: Cozzi P J; Padrid P; Tompkins M B; Alegre M L; Takeda J; Leff A R
Bioactivity of recombinant feline interleukin-2 on human and feline leukocytes.
Veterinary immunology and immunopathology 1995;48(1-2):27-33.
1995: Muñoz N M; Rabe K F; Vita A J; McAllister K; Mayer D; Weiss M; Leff A R
Paradoxical blockade of beta adrenergically mediated inhibition of stimulated eosinophil secretion by salmeterol.
The Journal of pharmacology and experimental therapeutics 1995;273(2):850-4.
1995: Hamann K J; Dowling T L; Neeley S P; Grant J A; Leff A R
Hyaluronic acid enhances cell proliferation during eosinopoiesis through the CD44 surface antigen.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(8):4073-80.
1995: Galens S; Muñoz N M; Rabe K F; Herrnreiter A; Mayer D; Morton B; McAllister K; Leff A R
Assessment of agonist- and cell-mediated responses in airway microsections by computerized videomicrometry.
The American journal of physiology 1995;268(3 Pt 1):L519-25.
1995: Muñoz N M; Leff A R
Blockade of eosinophil migration by 5-lipoxygenase and cyclooxygenase inhibition in explanted guinea pig trachealis.
The American journal of physiology 1995;268(3 Pt 1):L446-54.
1995: Munoz N M; Leff A R
New method for real-time measurements of changes in lumenal area of microsection explants of airways by videomicrometry.
Chest 1995;107(3 Suppl):146S-147S.
1995: Padrid P; Snook S; Finucane T; Shiue P; Cozzi P; Solway J; Leff A R
Persistent airway hyperresponsiveness and histologic alterations after chronic antigen challenge in cats.
American journal of respiratory and critical care medicine 1995;151(1):184-93.
1995: Padrid P A; Mitchell R W; Ndukwu I M; Spaethe S; Shiue P; Cozzi P; Leff A R; Shiou P [corrected to Shiue P ]
Cyproheptadine-induced attenuation of type-I immediate-hypersensitivity reactions of airway smooth muscle from immune-sensitized cats.
American journal of veterinary research 1995;56(1):109-15.
1994: Leff A R
Inflammatory mediation of airway hyperresponsiveness by peripheral blood granulocytes. The case for the eosinophil.
Chest 1994;106(4):1202-8.
1994: Rabe K F; Muñoz N M; Vita A J; Morton B E; Magnussen H; Leff A R
Contraction of human bronchial smooth muscle caused by activated human eosinophils.
The American journal of physiology 1994;267(3 Pt 1):L326-34.
1994: Mitchell R W; Rühlmann E; Magnussen H; Leff A R; Rabe K F
Passive sensitization of human bronchi augments smooth muscle shortening velocity and capacity.
The American journal of physiology 1994;267(2 Pt 1):L218-22.
1994: Neeley S P; Hamann K J; Dowling T L; McAllister K T; White S R; Leff A R
Augmentation of stimulated eosinophil degranulation by VLA-4 (CD49d)-mediated adhesion to fibronectin.
American journal of respiratory cell and molecular biology 1994;11(2):206-13.
1994: Sanghavi J N; Rabe K F; Kim J S; Magnussen H; Leff A R; White S R
Migration of human and guinea pig airway epithelial cells in response to calcitonin gene-related peptide.
American journal of respiratory cell and molecular biology 1994;11(2):181-7.
1994: Ndukwu I M; Solway J; Arbetter K; Uzendoski K; Leff A R; Mitchell R W
Immune sensitization augments epithelium-dependent spontaneous tone in guinea pig trachealis.
The American journal of physiology 1994;266(5 Pt 1):L485-92.
1994: Murphy T M; Ray D W; Alger L E; Phillips I J; Roach J C; Leff A R; Solway J
Ontogeny of dry gas hyperpnea-induced bronchoconstriction in guinea pigs.
Journal of applied physiology (Bethesda, Md. : 1985) 1994;76(3):1150-5.
1994: Munoz N M; Vita A J; Neeley S P; McAllister K; Spaethe S M; White S R; Leff A R
Beta adrenergic modulation of formyl-methionine-leucine-phenylalanine-stimulated secretion of eosinophil peroxidase and leukotriene C4.
The Journal of pharmacology and experimental therapeutics 1994;268(1):139-43.
1993: Mitchell R W; Ndukwu I M; Arbetter K; Solway J; Leff A R
Effect of airway inflammation on smooth muscle shortening and contractility in guinea pig trachealis.
The American journal of physiology 1993;265(6 Pt 1):L549-54.
1993: Hamann K J; Strek M E; Baranowski S L; Munoz N M; Williams F S; White S R; Vita A; Leff A R
Effects of activated eosinophils cultured from human umbilical cord blood on guinea pig trachealis.
The American journal of physiology 1993;265(3 Pt 1):L301-7.
1993: Cozzi P J; Padrid P A; Takeda J; Alegre M L; Yuhki N; Leff A R
Sequence and functional characterization of feline interleukin 2.
Biochemical and biophysical research communications 1993;194(3):1038-43.
1993: Hsiue T R; Leff A R; Garland A; Hershenson M B; Ray D W; Solway J
Impaired sensorineural function after allergen-induced mediator release.
The American review of respiratory disease 1993;148(2):447-54.
1993: Solway J; Kao B M; Jordan J E; Gitter B; Rodger I W; Howbert J J; Alger L E; Necheles J; Leff A R; Garland A
Tachykinin receptor antagonists inhibit hyperpnea-induced bronchoconstriction in guinea pigs.
The Journal of clinical investigation 1993;92(1):315-23.
1993: Mitchell R W; Ndukuw I M; Ikeda K; Arbetter K; Leff A R
Effect of immune sensitization on stimulated ACh release from trachealis muscle in vitro.
The American journal of physiology 1993;265(1 Pt 1):L13-8.
1993: Padrid P; Wolf R; Munoz N M; Spaethe S; Finucane T; Solway J; Leff A R
Augmented muscarinic responsiveness caused by 5-lipoxygenase products secreted from alveolar macrophages in isolated-perfused rat lung.
The American review of respiratory disease 1993;147(6 Pt 1):1514-20.
1993: Strek M E; White S R; Ndukwu I M; Munoz N M; Williams F S; Vita A J; Leff A R; Mitchell R W
Physiologic significance of epithelial removal on guinea pig tracheal smooth muscle response to acetylcholine and serotonin.
The American review of respiratory disease 1993;147(6 Pt 1):1477-82.
1993: Neeley S P; Hamann K J; White S R; Baranowski S L; Burch R A; Leff A R
Selective regulation of expression of surface adhesion molecules Mac-1, L-selectin, and VLA-4 on human eosinophils and neutrophils.
American journal of respiratory cell and molecular biology 1993;8(6):633-9.
1993: Strek M E; White S R; Hsiue T R; Kulp G V; Williams F S; Leff A R
Effect of mode of activation of human eosinophils on tracheal smooth muscle contraction in guinea pigs.
The American journal of physiology 1993;264(5 Pt 1):L475-81.
1993: White S R; Strek M E; Kulp G V; Spaethe S M; Burch R A; Neeley S P; Leff A R
Regulation of human eosinophil degranulation and activation by endogenous phospholipase A2.
The Journal of clinical investigation 1993;91(5):2118-25.
1993: Munoz N M; Hamann K J; Vita A; Cozzi P J; Baranowski S; Solway J; Leff A R
Activation of tracheal smooth muscle responsiveness by fMLP-treated HL-60 cells and neutrophils.
The American journal of physiology 1993;264(3 Pt 1):L222-8.
1993: Munoz N M; Zak R; Panettieri R A; Wiesner R; Leff A R
Changes in levels of mRNA encoding myosin heavy chain in porcine trachealis during ontogenesis.
American journal of respiratory cell and molecular biology 1993;8(3):252-7.
1993: Mitchell R W; Koenig S M; Popovich K J; Kelly E; Tallet J; Leff A R
Pertussis toxin augments beta-adrenergic relaxation of muscarinic contraction in canine trachealis.
The American review of respiratory disease 1993;147(2):327-31.
1992: Hsiue T R; Garland A; Ray D W; Hershenson M B; Leff A R; Solway J
Endogenous sensory neuropeptide release enhances nonspecific airway responsiveness in guinea pigs.
The American review of respiratory disease 1992;146(1):148-53.
1992: Strek M E; Garland A; Abrahams C; Leff A R; White S R
Direct effects and augmentation of airway smooth muscle contraction caused by phospholipase A2.
The American review of respiratory disease 1992;145(6):1463-8.
1992: Mitchell R W; Murphy T M; Leff A R
Physiological mechanisms mediating enhanced force generation during development and immune sensitization.
Canadian journal of physiology and pharmacology 1992;70(4):615-23.
1992: Ikeda K; Mitchell R W; Guest K A; Seow C Y; Kirchhoff C F; Murphy T M; Leff A R
Ontogeny of shortening velocity in porcine trachealis.
The American journal of physiology 1992;262(3 Pt 1):L280-5.
1992: White S R; Hathaway D P; Umans J G; Leff A R
Direct effects on airway smooth muscle contractile response caused by endothelin-1 in guinea pig trachealis.
The American review of respiratory disease 1992;145(2 Pt 1):491-3.
1991: Solway J; Leff A R
Sensory neuropeptides and airway function.
Journal of applied physiology (Bethesda, Md. : 1985) 1991;71(6):2077-87.
1991: White S R; Kulp G V; Spaethe S M; Van Alstyne E; Leff A R
A kinetic assay for eosinophil peroxidase activity in eosinophils and eosinophil conditioned media.
Journal of immunological methods 1991;144(2):257-63.
1991: Murphy T M; Mitchell R W; Phillips I J; Leff A R
Ontogenic expression of acetylcholinesterase activity in trachealis of young swine.
The American journal of physiology 1991;261(4 Pt 1):L322-6.
1991: Mitchell R W; Murphy T M; Kelly E; Leff A R
Extracellular Ca2+ mobilization in potential-dependent contraction of trachealis of maturing swine.
Journal of applied physiology (Bethesda, Md. : 1985) 1991;71(4):1489-95.
1991: White S R; Hathaway D P; Umans J G; Tallet J; Abrahams C; Leff A R
Epithelial modulation of airway smooth muscle response to endothelin-1.
The American review of respiratory disease 1991;144(2):373-8.
1991: Mitchell R W; Kelly E; Leff A R
Reduced activity of acetylcholinesterase in canine tracheal smooth muscle homogenates after active immune-sensitization.
American journal of respiratory cell and molecular biology 1991;5(1):56-62.
1991: Murphy T M; Mitchell R W; Halayko A; Roach J; Roy L; Kelly E A; Munoz N M; Stephens N L; Leff A R
Effect of maturational changes in myosin content and morphometry on airway smooth muscle contraction.
The American journal of physiology 1991;260(6 Pt 1):L471-80.
1991: Munoz N M; Kirchhoff C F; Strek M E; Blumenthal R N; Leff A R
Effects of PAF on isolated rat airways perfused with blood-free solution.
The American journal of physiology 1991;260(4 Pt 1):L260-7.
1991: Leff A R; Hamann K J; Wegner C D
Inflammation and cell-cell interactions in airway hyperresponsiveness.
The American journal of physiology 1991;260(4 Pt 1):L189-206.
1991: Mitchell R W; Kelly E; Leff A R
Effect of in vitro preconditioning on tracheal smooth muscle responsiveness.
The American journal of physiology 1991;260(2 Pt 1):L168-73.
1991: Murphy T M; Roy L; Phillips I J; Mitchell R W; Kelly E A; Munoz N M; Leff A R
Effect of maturation on topographic distribution of bronchoconstrictor responses in large diameter airways of young swine.
The American review of respiratory disease 1991;143(1):126-31.
1990: Wylam M E; Samsel R W; Umans J G; Mitchell R W; Leff A R; Schumacker P T
Endotoxin in vivo impairs endothelium-dependent relaxation of canine arteries in vitro.
The American review of respiratory disease 1990;142(6 Pt 1):1263-7.
1990: Ray D W; Eappen S; Hernandez C; Jackson M; Alger L E; Leff A R; Solway J
Distribution of airway narrowing during hyperpnea-induced bronchoconstriction in guinea pigs.
Journal of applied physiology (Bethesda, Md. : 1985) 1990;69(4):1323-9.
1990: White S R; Ohno S; Munoz N M; Gleich G J; Abrahams C; Solway J; Leff A R
Epithelium-dependent contraction of airway smooth muscle caused by eosinophil MBP.
The American journal of physiology 1990;259(4 Pt 1):L294-303.
1990: Mitchell R W; Murphy T M; Kelly E; Leff A R
Maturation of acetylcholinesterase expression in tracheal smooth muscle contraction.
The American journal of physiology 1990;259(2 Pt 1):L130-5.
1990: Brofman J D; Leff A R; Munoz N M; Kirchhoff C; White S R
Sympathetic secretory response to hypercapnic acidosis in swine.
Journal of applied physiology (Bethesda, Md. : 1985) 1990;69(2):710-7.
1989: Shioya T; Munoz N M; Leff A R
Translation of contractile force to constriction in major diameter canine airways in vivo.
The American review of respiratory disease 1989;140(3):687-94.
1989: Murphy T M; Mitchell R W; Blake J S; Mack M M; Kelly E A; Munoz N M; Leff A R
Expression of airway contractile properties and acetylcholinesterase activity in swine.
Journal of applied physiology (Bethesda, Md. : 1985) 1989;67(1):174-80.
1989: Koenig S M; Mitchell R W; Kelly E; White S R; Leff A R; Popovich K J
Beta-adrenergic relaxation of dog trachealis: contractile agonist-specific interaction.
Journal of applied physiology (Bethesda, Md. : 1985) 1989;67(1):181-5.
1989: Brofman J D; White S R; Blake J S; Munoz N M; Gleich G J; Leff A R
Epithelial augmentation of trachealis contraction caused by major basic protein of eosinophils.
Journal of applied physiology (Bethesda, Md. : 1985) 1989;66(4):1867-73.
1989: Munoz N M; Stimler-Gerard N P; Mack M M; Tutins C; Blake J S; Kelly E; Murphy T M; Leff A R
Evidence for platelet-activating factor secretion during immune activation in dogs.
Journal of applied physiology (Bethesda, Md. : 1985) 1989;66(4):1860-6.
1989: White S R; Blake J S; Murphy T M; Mack M M; Munoz N M; Leff A R
Effects of vasomotor- and mediator-induced hypotension on bronchomotor tone in swine.
Journal of applied physiology (Bethesda, Md. : 1985) 1989;66(4):1852-9.
1989: Ray D W; Hernandez C; Leff A R; Drazen J M; Solway J
Tachykinins mediate bronchoconstriction elicited by isocapnic hyperpnea in guinea pigs.
Journal of applied physiology (Bethesda, Md. : 1985) 1989;66(3):1108-12.
1989: Murphy T M; Munoz N M; Moss J; Blake J S; Mack M M; Leff A R
PAF-induced contraction of canine trachea mediated by 5-hydroxytryptamine in vivo.
Journal of applied physiology (Bethesda, Md. : 1985) 1989;66(2):638-43.
1989: Mitchell R W; Koenig S M; Kelly E; Stephens N L; Leff A R
Ca2+-dependent facilitated shortening in isotonic contraction of trachealis muscle.
Journal of applied physiology (Bethesda, Md. : 1985) 1989;66(2):632-7.
1989: Munoz N M; Chang S W; Murphy T M; Stimler-Gerard N P; Blake J; Mack M; Irvin C; Voelkel N F; Leff A R
Distribution of bronchoconstrictor responses in isolated-perfused rat lung.
Journal of applied physiology (Bethesda, Md. : 1985) 1989;66(1):202-9.
1989: White S R; Stimler-Gerard N P; Munoz N M; Popovich K J; Murphy T M; Blake J S; Mack M M; Leff A R
Effect of beta-adrenergic blockade and sympathetic stimulation on canine bronchial mast cell response to immune degranulation in vivo.
The American review of respiratory disease 1989;139(1):73-9.
1988: Kremser C B; Levitt N S; Borow K M; Jaspan J B; Lindbloom C; Polonsky K S; Leff A R
Oxygen uptake kinetics during exercise in diabetic neuropathy.
Journal of applied physiology (Bethesda, Md. : 1985) 1988;65(6):2665-71.
1988: Ferguson M K; Little L; Rizzo L; Popovich K J; Glonek G F; Leff A; Manjoney D; Little A G
Diffusing capacity predicts morbidity and mortality after pulmonary resection.
The Journal of thoracic and cardiovascular surgery 1988;96(6):894-900.
1988: Ray D W; Hernandez C; Munoz N; Leff A R; Solway J
Bronchoconstriction elicited by isocapnic hyperpnea in guinea pigs.
Journal of applied physiology (Bethesda, Md. : 1985) 1988;65(2):934-9.
1988: Popovich K J; Sheldon G; Mack M; Munoz N M; Denberg P; Blake J; White S R; Leff A R
Role of platelets in contraction of canine tracheal muscle elicited by PAF in vitro.
Journal of applied physiology (Bethesda, Md. : 1985) 1988;65(2):914-20.
1988: White S R; Popovich K J; Mitchell R W; Koenig S M; Mack M M; Munoz N M; Leff A R
Antagonism of relaxation to isoproterenol caused by agonist interactions.
Journal of applied physiology (Bethesda, Md. : 1985) 1988;64(6):2501-7.
1988: Leff A R
Neurohumoral regulation of airway contractile responses.
Chest 1988;93(6):1285-7.
1988: Leff A R
Endogenous regulation of bronchomotor tone.
The American review of respiratory disease 1988;137(5):1198-216.
1988: Leff A R; Munoz N M; Shioya T
Comparative distribution of cholinomimetic and parasympathetic contractile responses in the major diameter airways of dogs.
Pulmonary pharmacology 1988;1(3):107-12.
1987: Murphy T M; Munoz N M; Hirshman C A; Blake J S; Leff A R
Mechanisms of airway hypercontractility in basenji-greyhound dogs.
Journal of applied physiology (Bethesda, Md. : 1985) 1987;63(5):2008-14.
1987: Shioya T; Pollack E R; Munoz N M; Leff A R
Distribution of airway contractile responses in major resistance airways of the dog.
The American journal of pathology 1987;129(1):102-8.
1987: Shioya T; Solway J; Munoz N M; Mack M; Leff A R
Distribution of airway contractile responses within the major diameter bronchi during exogenous bronchoconstriction.
The American review of respiratory disease 1987;135(5):1105-11.
1987: White S R; Sands M F; Popovich K J; Murphy T M; Munoz N M; Blake J; Mack M; Shioya T; Leff A R
Homeostatic regulation of airway smooth muscle tone by catecholamine secretion in swine.
Journal of applied physiology (Bethesda, Md. : 1985) 1987;62(3):972-7.
1987: Shioya T; Munoz N M; Leff A R
Effect of resting smooth muscle length on contractile response in resistance airways.
Journal of applied physiology (Bethesda, Md. : 1985) 1987;62(2):711-7.
1987: Leff A R; White S R; Munoz N M; Popovich K J; Shioya T; Stimler-Gerard N P
Parasympathetic involvement in PAF-induced contraction in canine trachealis in vivo.
Journal of applied physiology (Bethesda, Md. : 1985) 1987;62(2):599-605.
1986: Munoz N M; Shioya T; Murphy T M; Primack S; Dame C; Sands M F; Leff A R
Potentiation of vagal contractile response by thromboxane mimetic U-46619.
Journal of applied physiology (Bethesda, Md. : 1985) 1986;61(3):1173-9.

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