Charles Leffler

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Kanu Alie; Leffler Charles W
Roles of glia limitans astrocytes and carbon monoxide in adenosine diphosphate-induced pial arteriolar dilation in newborn pigs.
Basuroy Shyamali; Bhattacharya Sujoy; Leffler Charles W; Parfenova Helena
Nox4 NADPH oxidase mediates oxidative stress and apoptosis caused by TNF-alpha in cerebral vascular endothelial cells.
Narayanan Nithya; Leffler Charles W; Daley Michael L
Assessment of cerebrovascular resistance with a model of cerebrovascular pressure transmission.

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All Publications

2009: Kanu Alie; Leffler Charles W
Roles of glia limitans astrocytes and carbon monoxide in adenosine diphosphate-induced pial arteriolar dilation in newborn pigs.
Stroke; a journal of cerebral circulation 2009;40(3):930-5.
2009: Basuroy Shyamali; Bhattacharya Sujoy; Leffler Charles W; Parfenova Helena
Nox4 NADPH oxidase mediates oxidative stress and apoptosis caused by TNF-alpha in cerebral vascular endothelial cells.
American journal of physiology. Cell physiology 2009;296(3):C422-32.
2009: Narayanan Nithya; Leffler Charles W; Daley Michael L
Assessment of cerebrovascular resistance with a model of cerebrovascular pressure transmission.
Medical engineering & physics 2009;31(2):254-60.
2008: Li Anlong; Xi Qi; Umstot Edward S; Bellner Lars; Schwartzman Michal L; Jaggar Jonathan H; Leffler Charles W
Astrocyte-derived CO is a diffusible messenger that mediates glutamate-induced cerebral arteriolar dilation by activating smooth muscle Cell KCa channels.
Circulation research 2008;102(2):234-41.
2008: Daley Michael L; Narayanan Nithya; Leffler Charles W; Eide Per Kristian
Stroke with subarachnoid hemorrhage: assessment of cerebrovascular pressure regulation and simulated cerebrovascular resistance.
Acta neurochirurgica. Supplement 2008;102():321-5.
2008: Narayanan Nithya; Leffler Charles W; Czosnyka Marek; Daley Michael L
Assessment of cerebrovascular resistance with model of cerebrovascular pressure transmission.
Acta neurochirurgica. Supplement 2008;102():37-41.
2008: Parfenova Helena; Leffler Charles W
Cerebroprotective functions of HO-2.
Current pharmaceutical design 2008;14(5):443-53.
2007: Holt David C; Fedinec Alexander L; Vaughn Ashley N; Leffler Charles W
Age and species dependence of pial arteriolar responses to topical carbon monoxide in vivo.
Experimental biology and medicine (Maywood, N.J.) 2007;232(11):1465-9.
2007: Kanu Alie; Leffler Charles W
Carbon monoxide and Ca2+-activated K+ channels in cerebral arteriolar responses to glutamate and hypoxia in newborn pigs.
American journal of physiology. Heart and circulatory physiology 2007;293(5):H3193-200.
2007: Zimmermann Aliz; Leffler Charles W; Tcheranova Dilyara; Fedinec Alexander L; Parfenova Helena
Cerebroprotective effects of the CO-releasing molecule CORM-A1 against seizure-induced neonatal vascular injury.
American journal of physiology. Heart and circulatory physiology 2007;293(4):H2501-7.
2007: Daley Michael L; Pourcyrous Massroor; Timmons Shelly D; Leffler Charles W
Mode changes of cerebrovascular pressure transmission induced by cerebral vasodilation.
Journal of neurotrauma 2007;24(3):559-66.
2006: Leffler Charles W; Parfenova Helena; Fedinec Alexander L; Basuroy Shyamali; Tcheranova Dilyara
Contributions of astrocytes and CO to pial arteriolar dilation to glutamate in newborn pigs.
American journal of physiology. Heart and circulatory physiology 2006;291(6):H2897-904.
2006: Basuroy Shyamali; Bhattacharya Sujoy; Tcheranova Dilyara; Qu Yan; Regan Raymond F; Leffler Charles W; Parfenova Helena
HO-2 provides endogenous protection against oxidative stress and apoptosis caused by TNF-alpha in cerebral vascular endothelial cells.
American journal of physiology. Cell physiology 2006;291(5):C897-908.
2006: Kanu Alie; Whitfield John; Leffler Charles W
Carbon monoxide contributes to hypotension-induced cerebrovascular vasodilation in piglets.
American journal of physiology. Heart and circulatory physiology 2006;291(5):H2409-14.
2006: Li Anlong; Adebiyi Adebowale; Leffler Charles W; Jaggar Jonathan H
KCa channel insensitivity to Ca2+ sparks underlies fractional uncoupling in newborn cerebral artery smooth muscle cells.
American journal of physiology. Heart and circulatory physiology 2006;291(3):H1118-25.
2006: Parfenova Helena; Basuroy Shyamali; Bhattacharya Sujoy; Tcheranova Dilyara; Qu Yan; Regan Raymond F; Leffler Charles W
Glutamate induces oxidative stress and apoptosis in cerebral vascular endothelial cells: contributions of HO-1 and HO-2 to cytoprotection.
American journal of physiology. Cell physiology 2006;290(5):C1399-410.
2006: Leffler Charles W; Parfenova Helena; Jaggar Jonathan H; Wang Rui
Carbon monoxide and hydrogen sulfide: gaseous messengers in cerebrovascular circulation.
Journal of applied physiology (Bethesda, Md. : 1985) 2006;100(3):1065-76.
2006: Kanu Alie; Gilpin David; Fedinec Alexander L; Leffler Charles W
Cyclooxygenase products stimulate carbon monoxide production by piglet cerebral microvessels.
Experimental biology and medicine (Maywood, N.J.) 2006;231(2):181-5.
2006: Daley M L; Leffler C W; Czosnyka M; Pickard J D
Intracranial pressure monitoring: modeling cerebrovascular pressure transmission.
Acta neurochirurgica. Supplement 2006;96():103-7.
2005: Yakubu Momoh A; Leffler Charles W
Regulation of cerebral microvascular endothelial cell cyclooxygenase-2 message and activity by blood derived vasoactive agents.
Brain research bulletin 2005;68(3):150-6.
2005: Jaggar Jonathan H; Li Anlong; Parfenova Helena; Liu Jianxi; Umstot Edward S; Dopico Alejandro M; Leffler Charles W
Heme is a carbon monoxide receptor for large-conductance Ca2+-activated K+ channels.
Circulation research 2005;97(8):805-12.
2005: Leffler Charles W; Balabanova Liliya; Fedinec Alexander L; Parfenova Helena
Nitric oxide increases carbon monoxide production by piglet cerebral microvessels.
American journal of physiology. Heart and circulatory physiology 2005;289(4):H1442-7.
2005: Leffler Charles W; Fedinec Alexander L; Parfenova Helena; Jaggar Jonathan H
Permissive contributions of NO and prostacyclin in CO-induced cerebrovascular dilation in piglets.
American journal of physiology. Heart and circulatory physiology 2005;289(1):H432-8.
2005: Parfenova Helena; Carratu Pierluigi; Tcheranova Dilyara; Fedinec Alex; Pourcyrous Massroor; Leffler Charles W
Epileptic seizures cause extended postictal cerebral vascular dysfunction that is prevented by HO-1 overexpression.
American journal of physiology. Heart and circulatory physiology 2005;288(6):H2843-50.
2005: Daley M L; Leffler C W; Czosnyka M; Pickard J D
Plateau waves: changes of cerebrovascular pressure transmission.
Acta neurochirurgica. Supplement 2005;95():327-32.
2004: Ahmed Abu; Waters Christopher M; Leffler Charles W; Jaggar Jonathan H
Ionic mechanisms mediating the myogenic response in newborn porcine cerebral arteries.
American journal of physiology. Heart and circulatory physiology 2004;287(5):H2061-9.
2004: Barkoudah Ebrahim; Jaggar Jonathan H; Leffler Charles W
The permissive role of endothelial NO in CO-induced cerebrovascular dilation.
American journal of physiology. Heart and circulatory physiology 2004;287(4):H1459-65.
2004: Pourcyrous Massroor; Bada Henrietta S; Blaho Kari E; Randolph Mildred M; Parfenova Helena; Mandrell Timothy D; Arheart Kris; Korones Sheldon B; Leffler Charles W
Chronic prenatal exposure to cocaine alters cerebrovascular responses in newborn pigs.
Experimental biology and medicine (Maywood, N.J.) 2004;229(8):819-25.
2004: Daley Michael L; Pourcyrous Massroor; Timmons Shelly D; Leffler Charles W
Assessment of cerebrovascular autoregulation: changes of highest modal frequency of cerebrovascular pressure transmission with cerebral perfusion pressure.
Stroke; a journal of cerebral circulation 2004;35(8):1952-6.
2004: Parfenova Helena; Daley Michael L; Carratu Pierluigi; Leffler Charles W
Heme oxygenase inhibition reduces neuronal activation evoked by bicuculline in newborn pigs.
Brain research 2004;1014(1-2):87-96.
2004: Xi Qi; Tcheranova Dilyara; Parfenova Helena; Horowitz Burton; Leffler Charles W; Jaggar Jonathan H
Carbon monoxide activates KCa channels in newborn arteriole smooth muscle cells by increasing apparent Ca2+ sensitivity of alpha-subunits.
American journal of physiology. Heart and circulatory physiology 2004;286(2):H610-8.
2004: Koneru Padmaja; Leffler Charles W
Role of cGMP in carbon monoxide-induced cerebral vasodilation in piglets.
American journal of physiology. Heart and circulatory physiology 2004;286(1):H304-9.
2003: Pasley Richard L; Leffler Charles W; Daley Michael L
Modeling modulation of intracranial pressure by variation of cerebral venous resistance induced by ventilation.
Annals of biomedical engineering 2003;31(10):1238-45.
2003: Daley Michael L; Pourcyrous Massroor; Timmons Shelly D; Leffler Charles W
Intracranial pressure dynamics: changes of bandwidth as an indicator of cerebrovascular tension.
Medical engineering & physics 2003;25(8):679-89.
2003: Carratu Pierluigi; Pourcyrous Massroor; Fedinec Alex; Leffler Charles W; Parfenova Helena
Endogenous heme oxygenase prevents impairment of cerebral vascular functions caused by seizures.
American journal of physiology. Heart and circulatory physiology 2003;285(3):H1148-57.
2003: Leffler Charles W; Balabanova Liliya; Sullivan C Dale; Wang Xiaohu; Fedinec Alexander L; Parfenova Helena
Regulation of CO production in cerebral microvessels of newborn pigs.
American journal of physiology. Heart and circulatory physiology 2003;285(1):H292-7.
2003: Leffler Charles W; Balabanova Liliya; Fedinec Alexander L; Waters Christopher M; Parfenova Helena
Mechanism of glutamate stimulation of CO production in cerebral microvessels.
American journal of physiology. Heart and circulatory physiology 2003;285(1):H74-80.
2003: Fiumana Elisa; Parfenova Helena; Jaggar Jonathan H; Leffler Charles W
Carbon monoxide mediates vasodilator effects of glutamate in isolated pressurized cerebral arterioles of newborn pigs.
American journal of physiology. Heart and circulatory physiology 2003;284(4):H1073-9.
2003: Parfenova Helena; Fedinec Alex; Leffler Charles W
Ionotropic glutamate receptors in cerebral microvascular endothelium are functionally linked to heme oxygenase.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2003;23(2):190-7.
2003: Heinonen Kirsti; Fedinec Alexander; Leffler Charles W
Dexamethasone pretreatment attenuates cerebral vasodilative responses to hypercapnia and augments vasoconstrictive responses to hyperventilation in newborn pigs.
Pediatric research 2003;53(2):260-5.
2003: Winestone John S; Bonner Clarissia; Leffler Charles W
Carbon monoxide as an attenuator of vasoconstriction in piglet cerebral arterioles.
Experimental biology and medicine (Maywood, N.J.) 2003;228(1):46-50.
2002: Fain J N; Kanu A; Bahouth S W; Cowan G S M; Hiler M L; Leffler C W
Comparison of PGE2, prostacyclin and leptin release by human adipocytes versus explants of adipose tissue in primary culture.
Prostaglandins, leukotrienes, and essential fatty acids 2002;67(6):467-73.
2002: Yakubu Momoh A; Leffler Charles W
L-type voltage-dependent Ca2+ channels in cerebral microvascular endothelial cells and ET-1 biosynthesis.
American journal of physiology. Cell physiology 2002;283(6):C1687-95.
2002: Jaggar Jonathan H; Leffler Charles W; Cheranov Serguei Y; Tcheranova Dilyara; E Shuyu; Cheng Xiaoyang
Carbon monoxide dilates cerebral arterioles by enhancing the coupling of Ca2+ sparks to Ca2+-activated K+ channels.
Circulation research 2002;91(7):610-7.
2002: Parfenova Helena; Levine Vladimir; Gunther Wendy M; Pourcyrous Massroor; Leffler Charles W
COX-1 and COX-2 contributions to basal and IL-1 beta-stimulated prostanoid synthesis in human neonatal cerebral microvascular endothelial cells.
Pediatric research 2002;52(3):342-8.
2002: Yakubu Momoh A; Pourcyrous Massroor; Randolph Mildred M; Blaho Kari E; Mandrell Timothy D; Bada Henrietta S; Leffler Charles W
Consequences of maternal cocaine on cerebral microvascular functions in piglets.
Brain research 2002;947(2):174-81.
2002: Robinson James S; Fedinec Alexander L; Leffler Charles W
Role of carbon monoxide in glutamate receptor-induced dilation of newborn pig pial arterioles.
American journal of physiology. Heart and circulatory physiology 2002;282(6):H2371-6.
2002: Pourcyrous Massroor; Bada Henrietta S; Parfenova Helena; Daley Michael L; Korones Sheldon B; Leffler Charles W
Cerebrovasodilatory contribution of endogenous carbon monoxide during seizures in newborn pigs.
Pediatric research 2002;51(5):579-85.
2002: Zhang Yifan; Leffler C W
Compensatory role of NO in cerebral circulation of piglets chronically treated with indomethacin.
American journal of physiology. Regulatory, integrative and comparative physiology 2002;282(2):R400-10.
2002: Daley M L; Pourcyous M; Stidham G; Timmons S D; Leffler C W
An estimated compliance index derived from intracranial pressure recording.
Acta neurochirurgica. Supplement 2002;81():183-5.
2002: Daley M L; Leffler C W; Jackson S; Piper I
Use of resistance-area product derived from Doppler MCA velocity to estimate the range of active cerebrovascular regulation.
Acta neurochirurgica. Supplement 2002;81():155-7.
2002: Daley M L; Pourcyous M; Willis A; Leffler C W
Variation of proposed correlation indices of cerebrovascular reactivity with change of arteriolar diameter.
Acta neurochirurgica. Supplement 2002;81():151-3.
2002: Daley M L; Pasley R L; Connolly M; Timmons S D; Angel J; Stidham G; Leffler C W
Spectral characteristics of B-waves and other low-frequency activity.
Acta neurochirurgica. Supplement 2002;81():147-50.
2002: Daley M L; Han S; Leffler C W
Cyclic variation of cerebral pial arteriolar diameter synchronized with positive-pressure inhalation.
Acta neurochirurgica. Supplement 2002;81():143-5.
2001: Willis A P; Leffler C W
Endothelial NO and prostanoid involvement in newborn and juvenile pig pial arteriolar vasomotor responses.
American journal of physiology. Heart and circulatory physiology 2001;281(6):H2366-77.
2001: Parfenova H; Neff R A; Alonso J S; Shlopov B V; Jamal C N; Sarkisova S A; Leffler C W
Cerebral vascular endothelial heme oxygenase: expression, localization, and activation by glutamate.
American journal of physiology. Cell physiology 2001;281(6):C1954-63.
2001: Leffler C W; Balabanova L
Mechanism of permissive prostacyclin action in cerebrovascular smooth muscle.
Prostaglandins & other lipid mediators 2001;66(3):145-53.
2001: Fain J N; Leffler C W; Cowan G S; Buffington C; Pouncey L; Bahouth S W
Stimulation of leptin release by arachidonic acid and prostaglandin E(2) in adipose tissue from obese humans.
Metabolism: clinical and experimental 2001;50(8):921-8.
2001: Parfenova H; Parfenov V N; Shlopov B V; Levine V; Falkos S; Pourcyrous M; Leffler C W
Dynamics of nuclear localization sites for COX-2 in vascular endothelial cells.
American journal of physiology. Cell physiology 2001;281(1):C166-78.
2001: Leffler C W; Nasjletti A; Johnson R A; Fedinec A L
Contributions of prostacyclin and nitric oxide to carbon monoxide-induced cerebrovascular dilation in piglets.
American journal of physiology. Heart and circulatory physiology 2001;280(4):H1490-5.
2000: Fain J N; Leffler C W; Bahouth S W; Rice A M; Rivkees S A
Regulation of leptin release and lipolysis by PGE2 in rat adipose tissue.
Prostaglandins & other lipid mediators 2000;62(4):343-50.
2000: Fain J N; Leffler C W; Bahouth S W
Eicosanoids as endogenous regulators of leptin release and lipolysis by mouse adipose tissue in primary culture.
Journal of lipid research 2000;41(10):1689-94.
2000: Parfenova H; Massie V; Leffler C W
Developmental changes in endothelium-derived vasorelaxant factors in cerebral circulation.
American journal of physiology. Heart and circulatory physiology 2000;278(3):H780-8.
2000: Levine V; Pourcyrous M; Bada H S; Parfenova H; Yang W; Korones S B; Leffler C W
Preservation of cerebrovascular tone and reactivity by sodium channel inhibition in experimental prolonged asphyxia in piglets.
Pediatric research 2000;47(3):376-80.
2000: Parkinson P A; Parfenova H; Leffler C W
Phospholipase C activation by prostacyclin receptor agonist in cerebral microvascular smooth muscle cells.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 2000;223(1):53-8.
2000: Yakubu M A; Leffler C W
Enhanced pial arteriolar sensitivity to bioactive agents following exposure to endothelin-1.
Life sciences 2000;66(4):307-16.
1999: Leffler C W; Balabanova L; Williams K K
cAMP production by piglet cerebral vascular smooth muscle cells: pH(o), pH(i), and permissive action of PGI(2).
The American journal of physiology 1999;277(5 Pt 2):H1878-83.
1999: Parfenova H; Haffner J; Leffler C W
Phosphorylation-dependent stimulation of prostanoid synthesis by nigericin in cerebral endothelial cells.
The American journal of physiology 1999;277(4 Pt 1):C728-38.
1999: Willis A P; Leffler C W
NO and prostanoids: age dependence of hypercapniaand histamine-induced dilations of pig pial arterioles.
The American journal of physiology 1999;277(1 Pt 2):H299-307.
1999: Leffler C W; Nasjletti A; Yu C; Johnson R A; Fedinec A L; Walker N
Carbon monoxide and cerebral microvascular tone in newborn pigs.
The American journal of physiology 1999;276(5 Pt 2):H1641-6.
1999: Pourcyrous M; Busija D W; Shibata M; Bada H S; Korones S B; Leffler C W
Cerebrovascular responses to therapeutic dose of indomethacin in newborn pigs.
Pediatric research 1999;45(4 Pt 1):582-7.
1999: Yakubu M A; Leffler C W
Regulation of ET-1 biosynthesis in cerebral microvascular endothelial cells by vasoactive agents and PKC.
The American journal of physiology 1999;276(2 Pt 1):C300-5.
1999: Parfenova H; Fedinec A; Leffler C W
Role of tyrosine phosphorylation in the regulation of cerebral vascular tone in newborn pig in vivo.
The American journal of physiology 1999;276(1 Pt 2):H185-93.
1999: Pourcyrous M; Bada H S; Yang W; Parfenova H; Wong S P; Korones S B; Leffler C W
Prognostic significance of cerebrospinal fluid cyclic adenosine monophosphate in neonatal asphyxia.
The Journal of pediatrics 1999;134(1):90-6.
1998: Albuquerque M L; Leffler C W
pHo, pHi, and PCO2 in stimulation of IP3 and [Ca2+]c in piglet cerebrovascular smooth muscle.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1998;219(3):226-34.
1998: Zucker B; Leffler C W
PTX-sensitive G proteins and permissive action of prostacyclin in newborn pig cerebral circulation.
The American journal of physiology 1998;275(1 Pt 2):H259-63.
1998: Parfenova H; Balabanova L; Leffler C W
Posttranslational regulation of cyclooxygenase by tyrosine phosphorylation in cerebral endothelial cells.
The American journal of physiology 1998;274(1 Pt 1):C72-81.
1998: Daley M L; Leffler C W
Correlation coefficient between intracranial and arterial pressures: a gauge of cerebral vascular dilation.
Acta neurochirurgica. Supplement 1998;71():285-8.
1997: Pourcyrous M; Parfenova H; Shibata M; Bada H S; Korones S B; Leffler C W
The effects of intraventricular/periventricular blood on cerebral 3',5'-cyclic adenosine monophosphate concentration and cerebrovascular reactivity in newborn pigs.
Pediatric research 1997;42(3):305-10.
1997: Yakubu M A; Liliom K; Tigyi G J; Leffler C W
Role of lysophosphatidic acid in endothelin-1- and hematoma-induced alteration of cerebral microcirculation.
The American journal of physiology 1997;273(2 Pt 2):R703-9.
1997: Parfenova H; Eidson T H; Leffler C W
Upregulation of COX-2 in cerebral microvascular endothelial cells by smooth muscle cell signals.
The American journal of physiology 1997;273(1 Pt 1):C277-88.
1997: Leffler C W; Fedinec A L
Newborn piglet cerebral microvascular responses to epoxyeicosatrienoic acids.
The American journal of physiology 1997;273(1 Pt 2):H333-8.
1997: Pourcyrous M; Parfenova H; Bada H S; Korones S B; Leffler C W
Changes in cerebral cyclic nucleotides and cerebral blood flow during prolonged asphyxia and recovery in newborn pigs.
Pediatric research 1997;41(5):617-23.
1997: Leffler C W; Smith J S; Edrington J L; Zuckerman S L; Parfenova H
Mechanisms of hypoxia-induced cerebrovascular dilation in the newborn pig.
The American journal of physiology 1997;272(3 Pt 2):H1323-32.
1997: Yakubu M A; Leffler C W
5-Hydroxytryptamine-induced vasoconstriction after cerebral hematoma in piglets.
Pediatric research 1997;41(3):317-20.
1997: Leffler C W; Parfenova H
Cerebral arteriolar dilation to hypoxia: role of prostanoids.
The American journal of physiology 1997;272(1 Pt 2):H418-24.
1997: Rama G P; Parfenova H; Leffler C W
Protein kinase Cs and tyrosine kinases in permissive action of prostacyclin on cerebrovascular regulation in newborn pigs.
Pediatric research 1997;41(1):83-9.
1997: Hayden J E; Leffler C W
The effects of treatment with indomethacin on the cerebral vasculature of newborn piglets before and during hemorrhagic hypotension.
Pediatric research 1997;41(1):78-82.
1996: Yakubu M A; Leffler C W
Role of endothelin-1 in cerebral hematoma-induced modification of cerebral vascular reactivity in piglets.
Brain research 1996;734(1-2):149-56.
1996: Zuckerman S L; Armstead W M; Hsu P; Shibata M; Leffler C W
Age dependence of cerebrovascular response mechanisms in domestic pigs.
The American journal of physiology 1996;271(2 Pt 2):H535-40.
1996: Hsu P; Haffner J; Albuquerque M L; Leffler C W
pHi in piglet cerebral microvascular endothelial cells: recovery from an acid load.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1996;212(3):256-62.
1996: Parfenova H; Leffler C W
Effects of hypercapnia on prostanoid and cAMP production by cerebral microvascular cell cultures.
The American journal of physiology 1996;270(5 Pt 1):C1503-10.
1996: Shibata M; Parfenova H; Zuckerman S L; Seyer J M; Krueger J M; Leffler C W
Interleukin-1 beta peptides induce cerebral pial arteriolar dilation in anesthetized newborn pigs.
The American journal of physiology 1996;270(5 Pt 2):R1044-50.
1996: Shibata M; Parfenova H; Zuckerman S L; Leffler C W
Tumor necrosis factor-alpha induces pial arteriolar dilation in newborn pigs.
Brain research bulletin 1996;39(4):241-7.
1995: Leffler C W; Fedinec A L; Shibata M
Prostacyclin receptor activation and pial arteriolar dilation after endothelial injury in piglets.
Stroke; a journal of cerebral circulation 1995;26(11):2103-10; discussion 2110-1.
1995: Yakubu M A; Shibata M; Leffler C W
Hematoma-induced enhanced cerebral vasoconstrictions to leukotriene C4 and endothelin-1 in piglets: role of prostanoids.
Pediatric research 1995;38(1):119-23.
1995: Tigyi G; Hong L; Yakubu M; Parfenova H; Shibata M; Leffler C W
Lysophosphatidic acid alters cerebrovascular reactivity in piglets.
The American journal of physiology 1995;268(5 Pt 2):H2048-55.
1995: Albuquerque M L; Lowery-Smith L; Hsu P; Parfenova H; Leffler C W
Low CO2 stimulates inositol phosphate turnover and increased inositol 1,4,5-trisphosphate levels in piglet cerebral microvascular smooth muscle cells.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1995;209(1):14-9.
1995: Parfenova H; Leffler C W
Functional study on vasodilator effects of prostaglandin E2 in the newborn pig cerebral circulation.
European journal of pharmacology 1995;278(2):133-42.
1995: Parfenova H; Zuckerman S; Leffler C W
Inhibitory effect of indomethacin on prostacyclin receptor-mediated cerebral vascular responses.
The American journal of physiology 1995;268(5 Pt 2):H1884-90.
1995: Hsu P; Albuquerque M L; Leffler C W
Mechanisms of hypercapnia-stimulated PG production in piglet cerebral microvascular endothelial cells.
The American journal of physiology 1995;268(2 Pt 2):H591-603.
1995: Eidson T H; Edrington J L; Albuquerque M L; Zuckerman S L; Leffler C W
Light/dye microvascular injury eliminates pial arteriolar dilation in hypotensive piglets.
Pediatric research 1995;37(1):10-4.
1995: Parfenova H; Hsu P; Leffler C W
Dilator prostanoid-induced cyclic AMP formation and release by cerebral microvascular smooth muscle cells: inhibition by indomethacin.
The Journal of pharmacology and experimental therapeutics 1995;272(1):44-52.
1994: Yakubu M A; Shibata M; Leffler C W
Subarachnoid hematoma attenuates vasodilation and potentiates vasoconstriction induced by vasoactive agents in newborn pigs.
Pediatric research 1994;36(5):589-94.
1994: Armstead W M; Zuckerman S L; Shibata M; Parfenova H; Leffler C W
Different pial arteriolar responses to acetylcholine in the newborn and juvenile pig.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1994;14(6):1088-95.
1994: Leffler C W; Mirro R; Pharris L J; Shibata M
Permissive role of prostacyclin in cerebral vasodilation to hypercapnia in newborn pigs.
The American journal of physiology 1994;267(1 Pt 2):H285-91.
1994: Zuckerman S L; Mirro R; Armstead W M; Shibata M; Leffler C W
Indomethacin reduces ischemia-induced alteration of blood-brain barrier transport in piglets.
The American journal of physiology 1994;266(6 Pt 2):H2198-203.
1994: Pourcyrous M; Leffler C W; Bada H S; Korones S B; Busija D W
Cerebral blood flow responses to indomethacin in awake newborn pigs.
Pediatric research 1994;35(5):565-70.
1994: Pomphrey M A; Zuckerman S; Shibata M; Leffler C W
Effect of indomethacin on piglet cerebral blood flow following total cerebral ischemia.
Journal of the Tennessee Medical Association 1994;87(5):199.
1994: Parfenova H; Shibata M; Zuckerman S; Leffler C W
CO2 and cerebral circulation in newborn pigs: cyclic nucleotides and prostanoids in vascular regulation.
The American journal of physiology 1994;266(4 Pt 2):H1494-501.
1994: Leffler C W; Mirro R; Shanklin D R; Armstead W M; Shibata M
Light/dye microvascular injury selectively eliminates hypercapnia-induced pial arteriolar dilation in newborn pigs.
The American journal of physiology 1994;266(2 Pt 2):H623-30.
1994: Shibata M; Mirro R; Armstead W M; Leffler C W
Actinomycin D blocks interleukin-1 alpha-induced pial arteriolar dilation and increased prostanoid production in newborn pigs.
Brain research bulletin 1994;33(4):403-9.
1993: Parfenova H; Shibata M; Zuckerman S; Mirro R; Leffler C W
Cyclic nucleotides and cerebrovascular tone in newborn pigs.
The American journal of physiology 1993;265(6 Pt 2):H1972-82.
1993: Parfenova H; Shibata M; Leffler C W
Subarachnoid blood causes pial arteriolar constriction in newborn pigs.
Stroke; a journal of cerebral circulation 1993;24(11):1729-34.
1993: Shibata M; Einhaus S; Schweitzer J B; Zuckerman S; Leffler C W
Cerebral blood flow decreased by adrenergic stimulation of cerebral vessels in anesthetized newborn pigs with traumatic brain injury.
Journal of neurosurgery 1993;79(5):696-704.
1993: Mirro R; Pharris L J; Armstead W M; Shibata M; Leffler C W
Effects of indomethacin on newborn pig pial arteriolar responses to PCO2.
Journal of applied physiology (Bethesda, Md. : 1985) 1993;75(3):1300-5.
1993: Pourcyrous M; Leffler C W; Bada H S; Korones S B; Busija D W
Brain superoxide anion generation in asphyxiated piglets and the effect of indomethacin at therapeutic dose.
Pediatric research 1993;34(3):366-9.
1993: Tong S; Parfenova H; Shibata M; Zuckerman S; Armstead W M; Leffler C W
Pituitary adenylate cyclase-activating polypeptide dilates cerebral arterioles of newborn pigs.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1993;203(3):343-7.
1993: Leffler C W; Mirro R; Shibata M; Parfenova H; Armstead W M; Zuckerman S
Effects of indomethacin on cerebral vasodilator responses to arachidonic acid and hypercapnia in newborn pigs.
Pediatric research 1993;33(6):609-14.
1993: Hsu P; Shibata M; Leffler C W
Prostanoid synthesis in response to high CO2 in newborn pig brain microvascular endothelial cells.
The American journal of physiology 1993;264(5 Pt 2):H1485-92.
1993: Armstead W M; Mirro R; Zuckerman S L; Shibata M; Leffler C W
Transforming growth factor-beta attenuates ischemia-induced alterations in cerebrovascular responses.
The American journal of physiology 1993;264(2 Pt 2):H381-5.
1993: Leffler C W; Thompson C C; Armstead W M; Mirro R; Shibata M; Busija D W
Superoxide scavengers do not prevent ischemia-induced alteration of cerebral vasodilation in piglets.
Pediatric research 1993;33(2):164-70.
1992: Armstead W M; Mirro R; Shibata M; Leffler C W
Prostanoids modulate opioid-induced increases in cerebrospinal fluid vasopressin concentration.
The American journal of physiology 1992;263(6 Pt 2):H1670-4.
1992: Mirro R; Lowery-Smith L; Armstead W M; Shibata M; Zuckerman S L; Leffler C W
Cerebral vasoconstriction in response to hypocapnia is maintained after ischemia/reperfusion injury in newborn pigs.
Stroke; a journal of cerebral circulation 1992;23(11):1613-6.
1992: Leffler C W; Mirro R; Armstead W M; Shibata M
Topical arachidonic acid restores pial arteriolar dilation to hypercapnia of postischemic newborn pig brain.
The American journal of physiology 1992;263(3 Pt 2):H746-51.
1992: Mirro R; Karanth S; Armstead W M; Shibata M; Leffler C W
Alterations in cerebrovascular reactivity after positive pressure ventilation.
Pediatric research 1992;32(1):114-7.
1992: Pourcyrous M; Leffler C W; Bada H S; Korones S B; Stidham G L; Busija D W
Effects of pancuronium bromide on cerebral blood flow changes during seizures in newborn pigs.
Pediatric research 1992;31(6):636-9.
1992: Armstead W M; Mirro R; Thelin O P; Shibata M; Zuckerman S L; Shanklin D R; Busija D W; Leffler C W
Polyethylene glycol superoxide dismutase and catalase attenuate increased blood-brain barrier permeability after ischemia in piglets.
Stroke; a journal of cerebral circulation 1992;23(5):755-62.
1992: Armstead W M; Crofton J T; Share L; Mirro R; Zuckerman S L; Leffler C W
Influence of opioids on CSF vasopressin concentration in newborn pigs.
The American journal of physiology 1992;262(3 Pt 2):H862-7.
1992: Armstead W M; Mirro R; Zuckerman S L; Leffler C W
Vasopressin modulates cerebrovascular responses to opioids in newborn pigs.
The Journal of pharmacology and experimental therapeutics 1992;260(3):1107-12.
1992: Shibata M; Leffler C W; Busija D W
Pial arteriolar constriction following cortical spreading depression is mediated by prostanoids.
Brain research 1992;572(1-2):190-7.
1992: Pharris L J; Mirro R; Leffler C W
Pial arterioles and hypocapnia.
Journal of the Tennessee Medical Association 1992;85(2):70.
1992: Armstead W M; Leffler C W
Neurohumoral regulation of the cerebral circulation.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1992;199(2):149-57.
1992: Armstead W M; Mirro R; Zuckerman S; Busija D W; Leffler C W
The influence of opioids on local cerebral glucose utilization in the newborn pig.
Brain research 1992;571(1):97-102.
1991: Shibata M; Leffler C W; Busija D W
Prostanoids attenuate pial arteriolar dilation induced by cortical spreading depression in rabbits.
The American journal of physiology 1991;261(4 Pt 2):R828-34.
1991: Leffler C W; Mirro R; Thompson C; Shibata M; Armstead W M; Pourcyrous M; Thelin O
Activated oxygen species do not mediate hypercapnia-induced cerebral vasodilation in newborn pigs.
The American journal of physiology 1991;261(2 Pt 2):H335-42.
1991: Mirro R; Armstead W M; Busija D W; Leffler C W
Blood to brain transport after newborn cerebral ischemia/reperfusion injury.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1991;197(3):268-72.
1991: Shibata M; Leffler C W; Busija D W
Evidence against parenchymal metabolites directly promoting pial arteriolar dilation during cortical spreading depression in rabbits.
Brain research bulletin 1991;26(5):753-8.
1991: Armstead W M; Mirro R; Busija D W; Leffler C W
Opioids and the prostanoid system in the control of cerebral blood flow in hypotensive piglets.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1991;11(3):380-7.
1991: Armstead W M; Mirro R; Busija D W; Desiderio D M; Leffler C W
Opioids in cerebrospinal fluid in hypotensive newborn pigs.
Circulation research 1991;68(4):922-9.
1991: Mirro R; Leffler C W; Armstead W M; Busija D W
Positive-pressure ventilation alters blood-to-brain and blood-to-CSF transport in neonatal pigs.
Journal of applied physiology (Bethesda, Md. : 1985) 1991;70(2):584-9.
1990: Mirro R; Leffler C W; Armstead W M; Busija D W
Pressure ventilation increases brain vascular prostacyclin production in newborn pigs.
Pediatric research 1990;28(6):609-12.
1990: Busija D W; Leffler C W; Wagerle L C
Mono-L-arginine-containing compounds dilate piglet pial arterioles via an endothelium-derived relaxing factor-like substance.
Circulation research 1990;67(6):1374-80.
1990: Pourcyrous M; Leffler C W; Mirro R; Busija D W
Brain superoxide anion generation during asphyxia and reventilation in newborn pigs.
Pediatric research 1990;28(6):618-21.
1990: Armstead W M; Mirro R; Busija D W; Leffler C W
Prostanoids modulate opioid cerebrovascular responses in newborn pigs.
The Journal of pharmacology and experimental therapeutics 1990;255(3):1083-9.
1990: Shibata M; Leffler C W; Busija D W
Recombinant human interleukin 1 alpha dilates pial arterioles and increases cerebrospinal fluid prostanoids in piglets.
The American journal of physiology 1990;259(5 Pt 2):H1486-91.
1990: Shibata M; Leffler C W; Busija D W
Cerebral hemodynamics during cortical spreading depression in rabbits.
Brain research 1990;530(2):267-74.
1990: Leffler C W; Busija D W; Armstead W M; Shanklin D R; Mirro R; Thelin O
Activated oxygen and arachidonate effects on newborn cerebral arterioles.
The American journal of physiology 1990;259(4 Pt 2):H1230-8.
1990: Pourcyrous M; Leffler C; Busija D
Role of prostanoids in cerebrovascular responses to asphyxia and reventilation in newborn pigs.
The American journal of physiology 1990;259(3 Pt 2):H662-7.
1990: Leffler C W; Mirro R; Armstead W M; Busija D W; Thelin O
Prostanoid synthesis and vascular responses to exogenous arachidonic acid following cerebral ischemia in piglets.
Prostaglandins 1990;40(3):241-8.
1990: Leffler C W; Busija D W; Armstead W M; Mirro R
H2O2 effects on cerebral prostanoids and pial arteriolar diameter in piglets.
The American journal of physiology 1990;258(5 Pt 2):H1382-7.
1990: White R P; Leffler C W; Bada H S
Eicosanoid levels in CSF of premature infants with posthemorrhagic hydrocephalus.
The American journal of the medical sciences 1990;299(4):230-5.
1990: Busija D W; Leffler C W
Perivascular blood attenuates noradrenergic but not cholinergic effects on piglet pial arterioles.
Stroke; a journal of cerebral circulation 1990;21(3):441-6.
1990: Armstead W M; Leffler C W; Busija D W; Mirro R
Vasopressin and prostanoid mechanisms in control of cerebral blood flow in hypotensive newborn pigs.
The American journal of physiology 1990;258(2 Pt 2):H408-13.
1989: Armstead W M; Mirro R; Busija D W; Leffler C W
Permissive role of prostanoids in acetylcholine-induced cerebral vasoconstriction.
The Journal of pharmacology and experimental therapeutics 1989;251(3):1012-9.
1989: Leffler C W; Busija D W; Mirro R; Armstead W M; Beasley D G
Effects of ischemia on brain blood flow and oxygen consumption of newborn pigs.
The American journal of physiology 1989;257(6 Pt 2):H1917-26.
1989: Mirro R; Armstead W M; Mirro J; Busija D W; Leffler C W
Blood-induced superoxide anion generation on the cerebral cortex of newborn pigs.
The American journal of physiology 1989;257(5 Pt 2):H1560-4.
1989: Sibai B M; Mirro R; Chesney C M; Leffler C
Low-dose aspirin in pregnancy.
Obstetrics and gynecology 1989;74(4):551-7.
1989: Bada H S; Green R S; Pourcyrous M; Leffler C W; Korones S B; Magill H L; Arheart K; Fitch C W; Anderson G D; Somes G
Indomethacin reduces the risks of severe intraventricular hemorrhage.
The Journal of pediatrics 1989;115(4):631-7.
1989: Busija D W; Leffler C W
Dilator effects of amino acid neurotransmitters on piglet pial arterioles.
The American journal of physiology 1989;257(4 Pt 2):H1200-3.
1989: Armstead W M; Mirro R; Leffler C W; Busija D W
Influence of endothelin on piglet cerebral microcirculation.
The American journal of physiology 1989;257(2 Pt 2):H707-10.
1989: Leffler C W; Beasley D G; Busija D W
Cerebral ischemia alters cerebral microvascular reactivity in newborn pigs.
The American journal of physiology 1989;257(1 Pt 2):H266-71.
1989: Rogers A H; Armstead W M; Mirro R; Busija D W; Leffler C W
Influence of intraarterial norepinephrine on cerebral hemodynamics of newborn pigs.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1989;191(2):174-8.
1989: Busija D W; Leffler C W
Effects of dopamine on pial arteriolar diameter and CSF prostanoid levels in piglets.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1989;9(3):264-7.
1989: Mirro R; Armstead W M; Beasley D G; Leffler C W
Lumbar CSF eicosanoids in neonates.
Prostaglandins, leukotrienes, and essential fatty acids 1989;36(2):77-9.
1989: Leffler C W; Busija D W; Beasley D G; Armstead W M; Mirro R
Postischemic cerebral microvascular responses to norepinephrine and hypotension in newborn pigs.
Stroke; a journal of cerebral circulation 1989;20(4):541-6.
1989: Armstead W M; Mirro R; Leffler C W; Busija D W
Cerebral superoxide anion generation during seizures in newborn pigs.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1989;9(2):175-9.
1989: Leffler C W; Busija D W; Armstead W M; Mirro R; Beasley D G
Ischemia alters cerebral vascular responses to hypercapnia and acetylcholine in piglets.
Pediatric research 1989;25(2):180-3.
1989: Busija D W; Armstead W; Leffler C W; Mirro R
Lipoxins A4 and B4 dilate cerebral arterioles of newborn pigs.
The American journal of physiology 1989;256(2 Pt 2):H468-71.
1989: Busija D W; Leffler C W
Role of prostanoids in cerebrovascular responses during seizures in piglets.
The American journal of physiology 1989;256(1 Pt 2):H120-5.
1989: Armstead W M; Mirro R; Busija D W; Leffler C W
Vascular responses to vasopressin are tone-dependent in the cerebral circulation of the newborn pig.
Circulation research 1989;64(1):136-44.
1988: Armstead W M; Mirro R; Leffler C W; Busija D W
Acetylcholine produces cerebrovascular constriction through activation of muscarinic-1 receptors in the newborn pig.
The Journal of pharmacology and experimental therapeutics 1988;247(3):926-33.
1988: Lovelady G K; Mirro R; Armstead W M; Busija D W; Leffler C W
Effect of 15-HETE on cerebral arterioles of newborn pigs.
Prostaglandins 1988;36(4):507-13.
1988: Pourcyrous M; Leffler C; Busija D
Postasphyxial increases in prostanoids in cerebrospinal fluid of piglets.
Pediatric research 1988;24(2):229-32.
1988: Busija D W; Leffler C W; Pourcyrous M
Hyperthermia increases cerebral metabolic rate and blood flow in neonatal pigs.
The American journal of physiology 1988;255(2 Pt 2):H343-6.
1988: Armstead W M; Mirro R; Busija D W; Leffler C W
Postischemic generation of superoxide anion by newborn pig brain.
The American journal of physiology 1988;255(2 Pt 2):H401-3.
1988: Mirro R; Busija D W; Armstead W M; Leffler C W
Histamine dilates pial arterioles of newborn pigs through prostanoid production.
The American journal of physiology 1988;254(6 Pt 2):H1023-6.
1988: Armstead W M; Leffler C W; Busija D W; Beasley D G; Mirro R
Adrenergic and prostanoid mechanisms in control of cerebral blood flow in hypotensive newborn pigs.
The American journal of physiology 1988;254(4 Pt 2):H671-7.
1988: Busija D W; Wagerle L C; Pourcyrous M; Leffler C W
Acetylcholine dramatically increases prostanoid synthesis in piglet parietal cortex.
Brain research 1988;439(1-2):122-6.
1988: Armstead W M; Pourcyrous M; Mirro R; Leffler C W; Busija D W
Platelet activating factor: a potent constrictor of cerebral arterioles in newborn pigs.
Circulation research 1988;62(1):1-7.
1988: Armstead W M; Mirro R; Leffler C W; Busija D W
The role of prostanoids in the mediation of responses to KC-404, a novel cerebrovasodilator.
The Journal of pharmacology and experimental therapeutics 1988;244(1):138-43.
1987: Mirro R; Armstead W; Busija D; Green R; Leffler C
Increasing ventilation pressure increases cortical subarachnoid cerebrospinal fluid prostanoids in newborn pigs.
Pediatric research 1987;22(6):647-50.
1987: Busija D W; Leffler C W
Hypothermia reduces cerebral metabolic rate and cerebral blood flow in newborn pigs.
The American journal of physiology 1987;253(4 Pt 2):H869-73.

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