Robert Lefkowitz

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Kovacs Jeffrey J; Hara Makoto R; Davenport Chandra L; Kim Jihee; Lefkowitz Robert J
Arrestin development: emerging roles for beta-arrestins in developmental signaling pathways.
Barak Larry S; Salahpour Ali; Zhang Xiaodong; Masri Bernard; Sotnikova Tatyana D; Ramsey Amy J; Violin Jonathan D; Lefkowitz Robert J; Caron Marc G; Gainetdinov Raul R
Pharmacological characterization of membrane-expressed human trace amine-associated receptor 1 (TAAR1) by a bioluminescence resonance energy transfer cAMP biosensor.
Ozawa Kentaro; Whalen Erin J; Nelson Christopher D; Mu Yuanyu; Hess Douglas T; Lefkowitz Robert J; Stamler Jonathan S
S-nitrosylation of beta-arrestin regulates beta-adrenergic receptor trafficking.

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All Publications

2009: Kovacs Jeffrey J; Hara Makoto R; Davenport Chandra L; Kim Jihee; Lefkowitz Robert J
Arrestin development: emerging roles for beta-arrestins in developmental signaling pathways.
Developmental cell 2009;17(4):443-58.
2008: Barak Larry S; Salahpour Ali; Zhang Xiaodong; Masri Bernard; Sotnikova Tatyana D; Ramsey Amy J; Violin Jonathan D; Lefkowitz Robert J; Caron Marc G; Gainetdinov Raul R
Pharmacological characterization of membrane-expressed human trace amine-associated receptor 1 (TAAR1) by a bioluminescence resonance energy transfer cAMP biosensor.
Molecular pharmacology 2008;74(3):585-94.
2008: Ozawa Kentaro; Whalen Erin J; Nelson Christopher D; Mu Yuanyu; Hess Douglas T; Lefkowitz Robert J; Stamler Jonathan S
S-nitrosylation of beta-arrestin regulates beta-adrenergic receptor trafficking.
Molecular cell 2008;31(3):395-405.
2008: Shukla Arun K; Violin Jonathan D; Whalen Erin J; Gesty-Palmer Diane; Shenoy Sudha K; Lefkowitz Robert J
Distinct conformational changes in beta-arrestin report biased agonism at seven-transmembrane receptors.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(29):9988-93.
2008: Nelson Christopher D; Kovacs Jeffery J; Nobles Kelly N; Whalen Erin J; Lefkowitz Robert J
Beta-arrestin scaffolding of phosphatidylinositol 4-phosphate 5-kinase Ialpha promotes agonist-stimulated sequestration of the beta2-adrenergic receptor.
The Journal of biological chemistry 2008;283(30):21093-101.
2008: Kim Jihee; Zhang Lisheng; Peppel Karsten; Wu Jiao-Hui; Zidar David A; Brian Leigh; DeWire Scott M; Exum Sabrina T; Lefkowitz Robert J; Freedman Neil J
Beta-arrestins regulate atherosclerosis and neointimal hyperplasia by controlling smooth muscle cell proliferation and migration.
Circulation research 2008;103(1):70-9.
2008: Kovacs Jeffrey J; Whalen Erin J; Liu Renshui; Xiao Kunhong; Kim Jihee; Chen Minyong; Wang Jiangbo; Chen Wei; Lefkowitz Robert J
Beta-arrestin-mediated localization of smoothened to the primary cilium.
Science (New York, N.Y.) 2008;320(5884):1777-81.
2008: Shukla Arun K; Sun Jin-Peng; Lefkowitz Robert J
Crystallizing thinking about the beta2-adrenergic receptor.
Molecular pharmacology 2008;73(5):1333-8.
2008: Lefkowitz Robert J
The annual ASCI meeting: does nostalgia have a future?
The Journal of clinical investigation 2008;118(4):1231-3.
2008: DeWire Scott M; Kim Jihee; Whalen Erin J; Ahn Seungkirl; Chen Minyong; Lefkowitz Robert J
Beta-arrestin-mediated signaling regulates protein synthesis.
The Journal of biological chemistry 2008;283(16):10611-20.
2008: Drake Matthew T; Violin Jonathan D; Whalen Erin J; Wisler James W; Shenoy Sudha K; Lefkowitz Robert J
beta-arrestin-biased agonism at the beta2-adrenergic receptor.
The Journal of biological chemistry 2008;283(9):5669-76.
2008: Violin Jonathan D; DiPilato Lisa M; Yildirim Necmettin; Elston Timothy C; Zhang Jin; Lefkowitz Robert J
beta2-adrenergic receptor signaling and desensitization elucidated by quantitative modeling of real time cAMP dynamics.
The Journal of biological chemistry 2008;283(5):2949-61.
2008: Beaulieu Jean-Martin; Marion Sébastien; Rodriguiz Ramona M; Medvedev Ivan O; Sotnikova Tatyana D; Ghisi Valentina; Wetsel William C; Lefkowitz Robert J; Gainetdinov Raul R; Caron Marc G
A beta-arrestin 2 signaling complex mediates lithium action on behavior.
Cell 2008;132(1):125-36.
2007: Wisler James W; DeWire Scott M; Whalen Erin J; Violin Jonathan D; Drake Matthew T; Ahn Seungkirl; Shenoy Sudha K; Lefkowitz Robert J
A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(42):16657-62.
2007: Shenoy Sudha K; Barak Larry S; Xiao Kunhong; Ahn Seungkirl; Berthouze Magali; Shukla Arun K; Luttrell Louis M; Lefkowitz Robert J
Ubiquitination of beta-arrestin links seven-transmembrane receptor endocytosis and ERK activation.
The Journal of biological chemistry 2007;282(40):29549-62.
2007: Noma Takahisa; Lemaire Anthony; Naga Prasad Sathyamangla V; Barki-Harrington Liza; Tilley Douglas G; Chen Juhsien; Le Corvoisier Philippe; Violin Jonathan D; Wei Huijun; Lefkowitz Robert J; Rockman Howard A
Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection.
The Journal of clinical investigation 2007;117(9):2445-58.
2007: Violin Jonathan D; Lefkowitz Robert J
Beta-arrestin-biased ligands at seven-transmembrane receptors.
Trends in pharmacological sciences 2007;28(8):416-22.
2007: Xiao Kunhong; McClatchy Daniel B; Shukla Arun K; Zhao Yang; Chen Minyong; Shenoy Sudha K; Yates John R; Lefkowitz Robert J
Functional specialization of beta-arrestin interactions revealed by proteomic analysis.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(29):12011-6.
2007: Nobles Kelly N; Guan Ziqiang; Xiao Kunhong; Oas Terrence G; Lefkowitz Robert J
The active conformation of beta-arrestin1: direct evidence for the phosphate sensor in the N-domain and conformational differences in the active states of beta-arrestins1 and -2.
The Journal of biological chemistry 2007;282(29):21370-81.
2007: Whalen Erin J; Foster Matthew W; Matsumoto Akio; Ozawa Kentaro; Violin Jonathan D; Que Loretta G; Nelson Chris D; Benhar Moran; Keys Janelle R; Rockman Howard A; Koch Walter J; Daaka Yehia; Lefkowitz Robert J; Stamler Jonathan S
Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2.
Cell 2007;129(3):511-22.
2007: Lefkowitz R J
Seven transmembrane receptors: something old, something new.
Acta physiologica (Oxford, England) 2007;190(1):9-19.
2007: Girnita Leonard; Shenoy Sudha K; Sehat Bita; Vasilcanu Radu; Vasilcanu Daiana; Girnita Ada; Lefkowitz Robert J; Larsson Olle
Beta-arrestin and Mdm2 mediate IGF-1 receptor-stimulated ERK activation and cell cycle progression.
The Journal of biological chemistry 2007;282(15):11329-38.
2007: Lefkowitz Robert J
Seven transmembrane receptors: a brief personal retrospective.
Biochimica et biophysica acta 2007;1768(4):748-55.
2007: Nelson Christopher D; Perry Stephen J; Regier Debra S; Prescott Stephen M; Topham Matthew K; Lefkowitz Robert J
Targeting of diacylglycerol degradation to M1 muscarinic receptors by beta-arrestins.
Science (New York, N.Y.) 2007;315(5812):663-6.
2007: DeWire Scott M; Ahn Seungkirl; Lefkowitz Robert J; Shenoy Sudha K
Beta-arrestins and cell signaling.
Annual review of physiology 2007;69():483-510.
2006: Lefkowitz Robert J; Rajagopal Keshava; Whalen Erin J
New roles for beta-arrestins in cell signaling: not just for seven-transmembrane receptors.
Molecular cell 2006;24(5):643-52.
2006: Violin Jonathan D; Dewire Scott M; Barnes William G; Lefkowitz Robert J
G protein-coupled receptor kinase and beta-arrestin-mediated desensitization of the angiotensin II type 1A receptor elucidated by diacylglycerol dynamics.
The Journal of biological chemistry 2006;281(47):36411-9.
2006: Rajagopal Keshava; Whalen Erin J; Violin Jonathan D; Stiber Jonathan A; Rosenberg Paul B; Premont Richard T; Coffman Thomas M; Rockman Howard A; Lefkowitz Robert J
Beta-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(44):16284-9.
2006: Meloni Alison R; Fralish Gregory B; Kelly Patrick; Salahpour Ali; Chen James K; Wechsler-Reya Robert J; Lefkowitz Robert J; Caron Marc G
Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2.
Molecular and cellular biology 2006;26(20):7550-60.
2006: Drake Matthew T; Shenoy Sudha K; Lefkowitz Robert J
Trafficking of G protein-coupled receptors.
Circulation research 2006;99(6):570-82.
2006: Violin Jonathan D; Ren Xiu-Rong; Lefkowitz Robert J
G-protein-coupled receptor kinase specificity for beta-arrestin recruitment to the beta2-adrenergic receptor revealed by fluorescence resonance energy transfer.
The Journal of biological chemistry 2006;281(29):20577-88.
2006: Reiter Eric; Lefkowitz Robert J
GRKs and beta-arrestins: roles in receptor silencing, trafficking and signaling.
Trends in endocrinology and metabolism: TEM 2006;17(4):159-65.
2006: Gesty-Palmer Diane; Chen Minyong; Reiter Eric; Ahn Seungkirl; Nelson Christopher D; Wang Shuntai; Eckhardt Allen E; Cowan Conrad L; Spurney Robert F; Luttrell Louis M; Lefkowitz Robert J
Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation.
The Journal of biological chemistry 2006;281(16):10856-64.
2006: Shenoy Sudha K; Drake Matthew T; Nelson Christopher D; Houtz Daniel A; Xiao Kunhong; Madabushi Srinivasan; Reiter Eric; Premont Richard T; Lichtarge Olivier; Lefkowitz Robert J
beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor.
The Journal of biological chemistry 2006;281(2):1261-73.
2005: Rajagopal Keshava; Lefkowitz Robert J; Rockman Howard A
When 7 transmembrane receptors are not G protein-coupled receptors.
The Journal of clinical investigation 2005;115(11):2971-4.
2005: Beaulieu Jean-Martin; Sotnikova Tatyana D; Marion Sébastien; Lefkowitz Robert J; Gainetdinov Raul R; Caron Marc G
An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior.
Cell 2005;122(2):261-73.
2005: Girnita Leonard; Shenoy Sudha K; Sehat Bita; Vasilcanu Radu; Girnita Ada; Lefkowitz Robert J; Larsson Olle
{beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase.
The Journal of biological chemistry 2005;280(26):24412-9.
2005: Milasta Sandra; Evans Nicholas A; Ormiston Laura; Wilson Shelagh; Lefkowitz Robert J; Milligan Graeme
The sustainability of interactions between the orexin-1 receptor and beta-arrestin-2 is defined by a single C-terminal cluster of hydroxy amino acids and modulates the kinetics of ERK MAPK regulation.
The Biochemical journal 2005;387(Pt 3):573-84.
2005: Shenoy Sudha K; Lefkowitz Robert J
Receptor-specific ubiquitination of beta-arrestin directs assembly and targeting of seven-transmembrane receptor signalosomes.
The Journal of biological chemistry 2005;280(15):15315-24.
2005: Hunton Dacia L; Barnes William G; Kim Jihee; Ren Xiu-Rong; Violin Jonathan D; Reiter Eric; Milligan Graeme; Patel Dhavalkumar D; Lefkowitz Robert J
Beta-arrestin 2-dependent angiotensin II type 1A receptor-mediated pathway of chemotaxis.
Molecular pharmacology 2005;67(4):1229-36.
2005: Barnes William G; Reiter Eric; Violin Jonathan D; Ren Xiu-Rong; Milligan Graeme; Lefkowitz Robert J
beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation.
The Journal of biological chemistry 2005;280(9):8041-50.
2005: Kim Jihee; Ahn Seungkirl; Ren Xiu-Rong; Whalen Erin J; Reiter Eric; Wei Huijun; Lefkowitz Robert J
Functional antagonism of different G protein-coupled receptor kinases for beta-arrestin-mediated angiotensin II receptor signaling.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(5):1442-7.
2005: Ren Xiu-Rong; Reiter Eric; Ahn Seungkirl; Kim Jihee; Chen Wei; Lefkowitz Robert J
Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(5):1448-53.
2005: Tachibana Hideo; Naga Prasad Sathyamangla V; Lefkowitz Robert J; Koch Walter J; Rockman Howard A
Level of beta-adrenergic receptor kinase 1 inhibition determines degree of cardiac dysfunction after chronic pressure overload-induced heart failure.
Circulation 2005;111(5):591-7.
2005: Lefkowitz Robert J
Summary of Wenner-Gren international symposium receptor-receptor interactions among heptaspanning membrane receptors: from structure to function.
Journal of molecular neuroscience : MN 2005;26(2-3):293-4.
2004: Chen Wei; Ren Xiu-Rong; Nelson Christopher D; Barak Larry S; Chen James K; Beachy Philip A; de Sauvage Frederic; Lefkowitz Robert J
Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2.
Science (New York, N.Y.) 2004;306(5705):2257-60.
2004: Xiao Kunhong; Shenoy Sudha K; Nobles Kelly; Lefkowitz Robert J
Activation-dependent conformational changes in {beta}-arrestin 2.
The Journal of biological chemistry 2004;279(53):55744-53.
2004: Martin Negin P; Whalen Erin J; Zamah Musa A; Pierce Kristen L; Lefkowitz Robert J
PKA-mediated phosphorylation of the beta1-adrenergic receptor promotes Gs/Gi switching.
Cellular signalling 2004;16(12):1397-403.
2004: Wei Huijun; Ahn Seungkirl; Barnes William G; Lefkowitz Robert J
Stable interaction between beta-arrestin 2 and angiotensin type 1A receptor is required for beta-arrestin 2-mediated activation of extracellular signal-regulated kinases 1 and 2.
The Journal of biological chemistry 2004;279(46):48255-61.
2004: Lefkowitz Robert J
Historical review: a brief history and personal retrospective of seven-transmembrane receptors.
Trends in pharmacological sciences 2004;25(8):413-22.
2004: Ahn Seungkirl; Shenoy Sudha K; Wei Huijun; Lefkowitz Robert J
Differential kinetic and spatial patterns of beta-arrestin and G protein-mediated ERK activation by the angiotensin II receptor.
The Journal of biological chemistry 2004;279(34):35518-25.
2004: Witherow D Scott; Garrison Tiffany Runyan; Miller William E; Lefkowitz Robert J
beta-Arrestin inhibits NF-kappaB activity by means of its interaction with the NF-kappaB inhibitor IkappaBalpha.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(23):8603-7.
2004: Freedman Neil J; Lefkowitz Robert J
Anti-beta(1)-adrenergic receptor antibodies and heart failure: causation, not just correlation.
The Journal of clinical investigation 2004;113(10):1379-82.
2004: Lefkowitz Robert J; Whalen Erin J
beta-arrestins: traffic cops of cell signaling.
Current opinion in cell biology 2004;16(2):162-8.
2004: Ahn Seungkirl; Wei Huijun; Garrison Tiffany Runyan; Lefkowitz Robert J
Reciprocal regulation of angiotensin receptor-activated extracellular signal-regulated kinases by beta-arrestins 1 and 2.
The Journal of biological chemistry 2004;279(9):7807-11.
2004: Walker J K L; Gainetdinov R R; Feldman D S; McFawn P K; Caron M G; Lefkowitz R J; Premont R T; Fisher J T
G protein-coupled receptor kinase 5 regulates airway responses induced by muscarinic receptor activation.
American journal of physiology. Lung cellular and molecular physiology 2004;286(2):L312-9.
2004: Gainetdinov Raul R; Premont Richard T; Bohn Laura M; Lefkowitz Robert J; Caron Marc G
Desensitization of G protein-coupled receptors and neuronal functions.
Annual review of neuroscience 2004;27():107-44.
2003: Povsic Thomas J; Kohout Trudy A; Lefkowitz Robert J
Beta-arrestin1 mediates insulin-like growth factor 1 (IGF-1) activation of phosphatidylinositol 3-kinase (PI3K) and anti-apoptosis.
The Journal of biological chemistry 2003;278(51):51334-9.
2003: Martin Negin P; Lefkowitz Robert J; Shenoy Sudha K
Regulation of V2 vasopressin receptor degradation by agonist-promoted ubiquitination.
The Journal of biological chemistry 2003;278(46):45954-9.
2003: Shenoy Sudha K; Lefkowitz Robert J
Multifaceted roles of beta-arrestins in the regulation of seven-membrane-spanning receptor trafficking and signalling.
The Biochemical journal 2003;375(Pt 3):503-15.
2003: Vines Charlotte M; Revankar Chetana M; Maestas Diane C; LaRusch Leah L; Cimino Daniel F; Kohout Trudy A; Lefkowitz Robert J; Prossnitz Eric R
N-formyl peptide receptors internalize but do not recycle in the absence of arrestins.
The Journal of biological chemistry 2003;278(43):41581-4.
2003: Chen Wei; Kirkbride Kellye C; How Tam; Nelson Christopher D; Mo Jinyao; Frederick Joshua P; Wang Xiao-Fan; Lefkowitz Robert J; Blobe Gerard C
Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signaling.
Science (New York, N.Y.) 2003;301(5638):1394-7.
2003: Chen Wei; ten Berge Derk; Brown Jeff; Ahn Seungkirl; Hu Liaoyuan A; Miller William E; Caron Marc G; Barak Larry S; Nusse Roel; Lefkowitz Robert J
Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4.
Science (New York, N.Y.) 2003;301(5638):1391-4.
2003: Wei Huijun; Ahn Seungkirl; Shenoy Sudha K; Karnik Sadashiva S; Hunyady László; Luttrell Louis M; Lefkowitz Robert J
Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(19):10782-7.
2003: Rapacciuolo Antonio; Suvarna Shayela; Barki-Harrington Liza; Luttrell Louis M; Cong Mei; Lefkowitz Robert J; Rockman Howard A
Protein kinase A and G protein-coupled receptor kinase phosphorylation mediates beta-1 adrenergic receptor endocytosis through different pathways.
The Journal of biological chemistry 2003;278(37):35403-11.
2003: Walker Julia K L; Fong Alan M; Lawson Barbara L; Savov Jordan D; Patel Dhavalkumar D; Schwartz David A; Lefkowitz Robert J
Beta-arrestin-2 regulates the development of allergic asthma.
The Journal of clinical investigation 2003;112(4):566-74.
2003: Hu Liaoyuan A; Chen Wei; Martin Negin P; Whalen Erin J; Premont Richard T; Lefkowitz Robert J
GIPC interacts with the beta1-adrenergic receptor and regulates beta1-adrenergic receptor-mediated ERK activation.
The Journal of biological chemistry 2003;278(28):26295-301.
2003: Miller William E; Houtz Daniel A; Nelson Christopher D; Kolattukudy P E; Lefkowitz Robert J
G-protein-coupled receptor (GPCR) kinase phosphorylation and beta-arrestin recruitment regulate the constitutive signaling activity of the human cytomegalovirus US28 GPCR.
The Journal of biological chemistry 2003;278(24):21663-71.
2003: Lodowski David T; Barnhill Jennifer F; Pitcher Julie A; Capel W Darrell; Lefkowitz Robert J; Tesmer John J G
Purification, crystallization and preliminary X-ray diffraction studies of a complex between G protein-coupled receptor kinase 2 and Gbeta1gamma2.
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 5):936-9.
2003: Lodowski David T; Pitcher Julie A; Capel W Darrell; Lefkowitz Robert J; Tesmer John J G
Keeping G proteins at bay: a complex between G protein-coupled receptor kinase 2 and Gbetagamma.
Science (New York, N.Y.) 2003;300(5623):1256-62.
2003: Gainetdinov Raul R; Bohn Laura M; Sotnikova Tatyana D; Cyr Michel; Laakso Aki; Macrae Alexander D; Torres Gonzalo E; Kim Kyeong Man; Lefkowitz Robert J; Caron Marc G; Premont Richard T
Dopaminergic supersensitivity in G protein-coupled receptor kinase 6-deficient mice.
Neuron 2003;38(2):291-303.
2003: Shenoy Sudha K; Lefkowitz Robert J
Trafficking patterns of beta-arrestin and G protein-coupled receptors determined by the kinetics of beta-arrestin deubiquitination.
The Journal of biological chemistry 2003;278(16):14498-506.
2003: Ahn Seungkirl; Nelson Christopher D; Garrison Tiffany Runyan; Miller William E; Lefkowitz Robert J
Desensitization, internalization, and signaling functions of beta-arrestins demonstrated by RNA interference.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(4):1740-4.
2003: Baillie George S; Sood Arvind; McPhee Ian; Gall Irene; Perry Stephen J; Lefkowitz Robert J; Houslay Miles D
beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(3):940-5.
2003: Tohgo Akira; Choy Eric W; Gesty-Palmer Diane; Pierce Kristen L; Laporte Stephane; Oakley Robert H; Caron Marc G; Lefkowitz Robert J; Luttrell Louis M
The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation.
The Journal of biological chemistry 2003;278(8):6258-67.
2003: Kohout Trudy A; Lefkowitz Robert J
Regulation of G protein-coupled receptor kinases and arrestins during receptor desensitization.
Molecular pharmacology 2003;63(1):9-18.
2002: Bohn Laura M; Lefkowitz Robert J; Caron Marc G
Differential mechanisms of morphine antinociceptive tolerance revealed in (beta)arrestin-2 knock-out mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(23):10494-500.
2002: Hanyaloglu Aylin C; Seeber Ruth M; Kohout Trudy A; Lefkowitz Robert J; Eidne Karin A
Homo- and hetero-oligomerization of thyrotropin-releasing hormone (TRH) receptor subtypes. Differential regulation of beta-arrestins 1 and 2.
The Journal of biological chemistry 2002;277(52):50422-30.
2002: Lefkowitz Robert J; Pierce Kristen L; Luttrell Louis M
Dancing with different partners: protein kinase a phosphorylation of seven membrane-spanning receptors regulates their G protein-coupling specificity.
Molecular pharmacology 2002;62(5):971-4.
2002: Perry Stephen J; Baillie George S; Kohout Trudy A; McPhee Ian; Magiera Maria M; Ang Kok Long; Miller William E; McLean Alison J; Conti Marco; Houslay Miles D; Lefkowitz Robert J
Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins.
Science (New York, N.Y.) 2002;298(5594):834-6.
2002: Freeman Jennifer L R; Gonzalo Philippe; Pitcher Julie A; Claing Audrey; Lavergne Jean-Pierre; Reboud Jean-Paul; Lefkowitz Robert J
Beta 2-adrenergic receptor stimulated, G protein-coupled receptor kinase 2 mediated, phosphorylation of ribosomal protein P2.
Biochemistry 2002;41(42):12850-7.
2002: Pierce Kristen L; Premont Richard T; Lefkowitz Robert J
Seven-transmembrane receptors.
Nature reviews. Molecular cell biology 2002;3(9):639-50.
2002: Lin Fang-Tsyr; Chen Wei; Shenoy Sudha; Cong Mei; Exum Sabrina T; Lefkowitz Robert J
Phosphorylation of beta-arrestin2 regulates its function in internalization of beta(2)-adrenergic receptors.
Biochemistry 2002;41(34):10692-9.
2002: Zamah A Musa; Delahunty Martha; Luttrell Louis M; Lefkowitz Robert J
Protein kinase A-mediated phosphorylation of the beta 2-adrenergic receptor regulates its coupling to Gs and Gi. Demonstration in a reconstituted system.
The Journal of biological chemistry 2002;277(34):31249-56.
2002: Ahn Seungkirl; Kim Jihee; Lucaveche Carmen L; Reedy Mary C; Luttrell Louis M; Lefkowitz Robert J; Daaka Yehia
Src-dependent tyrosine phosphorylation regulates dynamin self-assembly and ligand-induced endocytosis of the epidermal growth factor receptor.
The Journal of biological chemistry 2002;277(29):26642-51.
2002: Eckhart Andrea D; Fentzke Richard C; Lepore John; Lang Roberto; Lin Hua; Lefkowitz Robert J; Koch Walter J; Leiden Jeffrey M
Inhibition of betaARK1 restores impaired biochemical beta-adrenergic receptor responsiveness but does not rescue CREB(A133) induced cardiomyopathy.
Journal of molecular and cellular cardiology 2002;34(6):669-77.
2002: Fong Alan M; Premont Richard T; Richardson Ricardo M; Yu Yen-Rei A; Lefkowitz Robert J; Patel Dhavalkumar D
Defective lymphocyte chemotaxis in beta-arrestin2- and GRK6-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(11):7478-83.
2002: Perry Stephen J; Lefkowitz Robert J
Arresting developments in heptahelical receptor signaling and regulation.
Trends in cell biology 2002;12(3):130-8.
2002: Tohgo Akira; Pierce Kristen L; Choy Eric W; Lefkowitz Robert J; Luttrell Louis M
beta-Arrestin scaffolding of the ERK cascade enhances cytosolic ERK activity but inhibits ERK-mediated transcription following angiotensin AT1a receptor stimulation.
The Journal of biological chemistry 2002;277(11):9429-36.
2002: Claing Audrey; Laporte Stéphane A; Caron Marc G; Lefkowitz Robert J
Endocytosis of G protein-coupled receptors: roles of G protein-coupled receptor kinases and beta-arrestin proteins.
Progress in neurobiology 2002;66(2):61-79.
2002: Luttrell Louis M; Lefkowitz Robert J
The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signals.
Journal of cell science 2002;115(Pt 3):455-65.
2002: Rockman Howard A; Koch Walter J; Lefkowitz Robert J
Seven-transmembrane-spanning receptors and heart function.
Nature 2002;415(6868):206-12.
2002: Hu Liaoyuan A; Chen Wei; Premont Richard T; Cong Mei; Lefkowitz Robert J
G protein-coupled receptor kinase 5 regulates beta 1-adrenergic receptor association with PSD-95.
The Journal of biological chemistry 2002;277(2):1607-13.
2002: Paing May M; Stutts Amy B; Kohout Trudy A; Lefkowitz Robert J; Trejo JoAnn
beta -Arrestins regulate protease-activated receptor-1 desensitization but not internalization or Down-regulation.
The Journal of biological chemistry 2002;277(2):1292-300.
2001: Chen W; Hu L A; Semenov M V; Yanagawa S; Kikuchi A; Lefkowitz R J; Miller W E
beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(26):14889-94.
2001: Kohout T A; Takaoka H; McDonald P H; Perry S J; Mao L; Lefkowitz R J; Rockman H A
Augmentation of cardiac contractility mediated by the human beta(3)-adrenergic receptor overexpressed in the hearts of transgenic mice.
Circulation 2001;104(20):2485-91.
2001: Shenoy S K; McDonald P H; Kohout T A; Lefkowitz R J
Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin.
Science (New York, N.Y.) 2001;294(5545):1307-13.
2001: Cong M; Perry S J; Hu L A; Hanson P I; Claing A; Lefkowitz R J
Binding of the beta2 adrenergic receptor to N-ethylmaleimide-sensitive factor regulates receptor recycling.
The Journal of biological chemistry 2001;276(48):45145-52.
2001: Claing A; Chen W; Miller W E; Vitale N; Moss J; Premont R T; Lefkowitz R J
beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis.
The Journal of biological chemistry 2001;276(45):42509-13.
2001: Lefkowitz R J
2001: An AAP (Association of American Physicians) odyssey.
The Journal of clinical investigation 2001;108(7):s9-s13.
2001: McDonald P H; Lefkowitz R J
Beta-Arrestins: new roles in regulating heptahelical receptors' functions.
Cellular signalling 2001;13(10):683-9.
2001: Pierce K L; Lefkowitz R J
Classical and new roles of beta-arrestins in the regulation of G-protein-coupled receptors.
Nature reviews. Neuroscience 2001;2(10):727-33.
2001: Iaccarino G; Keys J R; Rapacciuolo A; Shotwell K F; Lefkowitz R J; Rockman H A; Koch W J
Regulation of myocardial betaARK1 expression in catecholamine-induced cardiac hypertrophy in transgenic mice overexpressing alpha1B-adrenergic receptors.
Journal of the American College of Cardiology 2001;38(2):534-40.
2001: Miller W E; McDonald P H; Cai S F; Field M E; Davis R J; Lefkowitz R J
Identification of a motif in the carboxyl terminus of beta -arrestin2 responsible for activation of JNK3.
The Journal of biological chemistry 2001;276(30):27770-7.
2001: Pierce K L; Tohgo A; Ahn S; Field M E; Luttrell L M; Lefkowitz R J
Epidermal growth factor (EGF) receptor-dependent ERK activation by G protein-coupled receptors: a co-culture system for identifying intermediates upstream and downstream of heparin-binding EGF shedding.
The Journal of biological chemistry 2001;276(25):23155-60.
2001: Harding V B; Jones L R; Lefkowitz R J; Koch W J; Rockman H A
Cardiac beta ARK1 inhibition prolongs survival and augments beta blocker therapy in a mouse model of severe heart failure.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(10):5809-14.
2001: Cong M; Perry S J; Lin F T; Fraser I D; Hu L A; Chen W; Pitcher J A; Scott J D; Lefkowitz R J
Regulation of membrane targeting of the G protein-coupled receptor kinase 2 by protein kinase A and its anchoring protein AKAP79.
The Journal of biological chemistry 2001;276(18):15192-9.
2001: Miller W E; Lefkowitz R J
Expanding roles for beta-arrestins as scaffolds and adapters in GPCR signaling and trafficking.
Current opinion in cell biology 2001;13(2):139-45.
2001: Pierce K L; Luttrell L M; Lefkowitz R J
New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades.
Oncogene 2001;20(13):1532-9.
2001: Shah A S; White D C; Emani S; Kypson A P; Lilly R E; Wilson K; Glower D D; Lefkowitz R J; Koch W J
In vivo ventricular gene delivery of a beta-adrenergic receptor kinase inhibitor to the failing heart reverses cardiac dysfunction.
Circulation 2001;103(9):1311-6.
2001: Miller W E; Lefkowitz R J
Arrestins as signaling molecules involved in apoptotic pathways: a real eye opener.
Science's STKE : signal transduction knowledge environment 2001;2001(69):pe1.
2001: Luttrell L M; Roudabush F L; Choy E W; Miller W E; Field M E; Pierce K L; Lefkowitz R J
Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(5):2449-54.
2001: Kohout T A; Lin F S; Perry S J; Conner D A; Lefkowitz R J
beta-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(4):1601-6.
2000: Bohn L M; Gainetdinov R R; Lin F T; Lefkowitz R J; Caron M G
Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence.
Nature 2000;408(6813):720-3.
2000: Cao W; Luttrell L M; Medvedev A V; Pierce K L; Daniel K W; Dixon T M; Lefkowitz R J; Collins S
Direct binding of activated c-Src to the beta 3-adrenergic receptor is required for MAP kinase activation.
The Journal of biological chemistry 2000;275(49):38131-4.
2000: Hu L A; Tang Y; Miller W E; Cong M; Lau A G; Lefkowitz R J; Hall R A
beta 1-adrenergic receptor association with PSD-95. Inhibition of receptor internalization and facilitation of beta 1-adrenergic receptor interaction with N-methyl-D-aspartate receptors.
The Journal of biological chemistry 2000;275(49):38659-66.
2000: McDonald P H; Chow C W; Miller W E; Laporte S A; Field M E; Lin F T; Davis R J; Lefkowitz R J
Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3.
Science (New York, N.Y.) 2000;290(5496):1574-7.
2000: Maudsley S; Zamah A M; Rahman N; Blitzer J T; Luttrell L M; Lefkowitz R J; Hall R A
Platelet-derived growth factor receptor association with Na(+)/H(+) exchanger regulatory factor potentiates receptor activity.
Molecular and cellular biology 2000;20(22):8352-63.
2000: Shah A S; White D C; Tai O; Hata J A; Wilson K H; Pippen A; Kypson A P; Glower D D; Lefkowitz R J; Koch W J
Adenovirus-mediated genetic manipulation of the myocardial beta-adrenergic signaling system in transplanted hearts.
The Journal of thoracic and cardiovascular surgery 2000;120(3):581-8.
2000: Premont R T; Claing A; Vitale N; Perry S J; Lefkowitz R J
The GIT family of ADP-ribosylation factor GTPase-activating proteins. Functional diversity of GIT2 through alternative splicing.
The Journal of biological chemistry 2000;275(29):22373-80.
2000: Lefkowitz R J
The superfamily of heptahelical receptors.
Nature cell biology 2000;2(7):E133-6.
2000: Freeman J L; Pitcher J A; Li X; Bennett V; Lefkowitz R J
alpha-Actinin is a potent regulator of G protein-coupled receptor kinase activity and substrate specificity in vitro.
FEBS letters 2000;473(3):280-4.
2000: Vitale N; Patton W A; Moss J; Vaughan M; Lefkowitz R J; Premont R T
GIT proteins, A novel family of phosphatidylinositol 3,4, 5-trisphosphate-stimulated GTPase-activating proteins for ARF6.
The Journal of biological chemistry 2000;275(18):13901-6.
2000: White D C; Hata J A; Shah A S; Glower D D; Lefkowitz R J; Koch W J
Preservation of myocardial beta-adrenergic receptor signaling delays the development of heart failure after myocardial infarction.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(10):5428-33.
2000: Miller W E; Maudsley S; Ahn S; Khan K D; Luttrell L M; Lefkowitz R J
beta-arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC. Role of beta-arrestin1-dependent targeting of c-SRC in receptor endocytosis.
The Journal of biological chemistry 2000;275(15):11312-9.
2000: Fraser I D; Cong M; Kim J; Rollins E N; Daaka Y; Lefkowitz R J; Scott J D
Assembly of an A kinase-anchoring protein-beta(2)-adrenergic receptor complex facilitates receptor phosphorylation and signaling.
Current biology : CB 2000;10(7):409-12.
2000: Maudsley S; Pierce K L; Zamah A M; Miller W E; Ahn S; Daaka Y; Lefkowitz R J; Luttrell L M
The beta(2)-adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptor.
The Journal of biological chemistry 2000;275(13):9572-80.
2000: Pierce K L; Maudsley S; Daaka Y; Luttrell L M; Lefkowitz R J
Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(4):1489-94.
2000: Claing A; Perry S J; Achiriloaie M; Walker J K; Albanesi J P; Lefkowitz R J; Premont R T
Multiple endocytic pathways of G protein-coupled receptors delineated by GIT1 sensitivity.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(3):1119-24.
2000: Shah A S; Lilly R E; Kypson A P; Tai O; Hata J A; Pippen A; Silvestry S C; Lefkowitz R J; Glower D D; Koch W J
Intracoronary adenovirus-mediated delivery and overexpression of the beta(2)-adrenergic receptor in the heart : prospects for molecular ventricular assistance.
Circulation 2000;101(4):408-14.
2000: Eckhart A D; Duncan S J; Penn R B; Benovic J L; Lefkowitz R J; Koch W J
Hybrid transgenic mice reveal in vivo specificity of G protein-coupled receptor kinases in the heart.
Circulation research 2000;86(1):43-50.
2000: Koch W J; Lefkowitz R J; Rockman H A
Functional consequences of altering myocardial adrenergic receptor signaling.
Annual review of physiology 2000;62():237-60.
1999: Gainetdinov R R; Bohn L M; Walker J K; Laporte S A; Macrae A D; Caron M G; Lefkowitz R J; Premont R T
Muscarinic supersensitivity and impaired receptor desensitization in G protein-coupled receptor kinase 5-deficient mice.
Neuron 1999;24(4):1029-36.
1999: Bohn L M; Lefkowitz R J; Gainetdinov R R; Peppel K; Caron M G; Lin F T
Enhanced morphine analgesia in mice lacking beta-arrestin 2.
Science (New York, N.Y.) 1999;286(5449):2495-8.
1999: Pitcher J A; Tesmer J J; Freeman J L; Capel W D; Stone W C; Lefkowitz R J
Feedback inhibition of G protein-coupled receptor kinase 2 (GRK2) activity by extracellular signal-regulated kinases.
The Journal of biological chemistry 1999;274(49):34531-4.
1999: Tang Y; Hu L A; Miller W E; Ringstad N; Hall R A; Pitcher J A; DeCamilli P; Lefkowitz R J
Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the beta1-adrenergic receptor.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(22):12559-64.
1999: Premont R T; Macrae A D; Aparicio S A; Kendall H E; Welch J E; Lefkowitz R J
The GRK4 subfamily of G protein-coupled receptor kinases. Alternative splicing, gene organization, and sequence conservation.
The Journal of biological chemistry 1999;274(41):29381-9.
1999: Iaccarino G; Lefkowitz R J; Koch W J
Myocardial G protein-coupled receptor kinases: implications for heart failure therapy.
Proceedings of the Association of American Physicians 1999;111(5):399-405.
1999: Hall R A; Spurney R F; Premont R T; Rahman N; Blitzer J T; Pitcher J A; Lefkowitz R J
G protein-coupled receptor kinase 6A phosphorylates the Na(+)/H(+) exchanger regulatory factor via a PDZ domain-mediated interaction.
The Journal of biological chemistry 1999;274(34):24328-34.
1999: Akhter S A; Eckhart A D; Rockman H A; Shotwell K; Lefkowitz R J; Koch W J
In vivo inhibition of elevated myocardial beta-adrenergic receptor kinase activity in hybrid transgenic mice restores normal beta-adrenergic signaling and function.
Circulation 1999;100(6):648-53.
1999: Kypson A; Hendrickson S; Akhter S; Wilson K; McDonald P; Lilly R; Dolber P; Glower D; Lefkowitz R; Koch W
Adenovirus-mediated gene transfer of the beta2-adrenergic receptor to donor hearts enhances cardiac function.
Gene therapy 1999;6(7):1298-304.
1999: Maurice J P; Hata J A; Shah A S; White D C; McDonald P H; Dolber P C; Wilson K H; Lefkowitz R J; Glower D D; Koch W J
Enhancement of cardiac function after adenoviral-mediated in vivo intracoronary beta2-adrenergic receptor gene delivery.
The Journal of clinical investigation 1999;104(1):21-9.
1999: Lin F T; Miller W E; Luttrell L M; Lefkowitz R J
Feedback regulation of beta-arrestin1 function by extracellular signal-regulated kinases.
The Journal of biological chemistry 1999;274(23):15971-4.
1999: Della Rocca G J; Maudsley S; Daaka Y; Lefkowitz R J; Luttrell L M
Pleiotropic coupling of G protein-coupled receptors to the mitogen-activated protein kinase cascade. Role of focal adhesions and receptor tyrosine kinases.
The Journal of biological chemistry 1999;274(20):13978-84.
1999: Luttrell L M; Daaka Y; Lefkowitz R J
Regulation of tyrosine kinase cascades by G-protein-coupled receptors.
Current opinion in cell biology 1999;11(2):177-83.
1999: Walker J K; Peppel K; Lefkowitz R J; Caron M G; Fisher J T
Altered airway and cardiac responses in mice lacking G protein-coupled receptor kinase 3.
The American journal of physiology 1999;276(4 Pt 2):R1214-21.
1999: McDonald P H; Cote N L; Lin F T; Premont R T; Pitcher J A; Lefkowitz R J
Identification of NSF as a beta-arrestin1-binding protein. Implications for beta2-adrenergic receptor regulation.
The Journal of biological chemistry 1999;274(16):10677-80.
1999: Iaccarino G; Smithwick L A; Lefkowitz R J; Koch W J
Targeting Gbeta gamma signaling in arterial vascular smooth muscle proliferation: a novel strategy to limit restenosis.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(7):3945-50.
1999: Della Rocca G J; Mukhin Y V; Garnovskaya M N; Daaka Y; Clark G J; Luttrell L M; Lefkowitz R J; Raymond J R
Serotonin 5-HT1A receptor-mediated Erk activation requires calcium/calmodulin-dependent receptor endocytosis.
The Journal of biological chemistry 1999;274(8):4749-53.
1999: Iaccarino G; Dolber P C; Lefkowitz R J; Koch W J
Bbeta-adrenergic receptor kinase-1 levels in catecholamine-induced myocardial hypertrophy: regulation by beta- but not alpha1-adrenergic stimulation.
Hypertension 1999;33(1 Pt 2):396-401.
1999: Luttrell L M; Ferguson S S; Daaka Y; Miller W E; Maudsley S; Della Rocca G J; Lin F; Kawakatsu H; Owada K; Luttrell D K; Caron M G; Lefkowitz R J
Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes.
Science (New York, N.Y.) 1999;283(5402):655-61.
1999: Ahn S; Maudsley S; Luttrell L M; Lefkowitz R J; Daaka Y
Src-mediated tyrosine phosphorylation of dynamin is required for beta2-adrenergic receptor internalization and mitogen-activated protein kinase signaling.
The Journal of biological chemistry 1999;274(3):1185-8.
1998: Premont R T; Claing A; Vitale N; Freeman J L; Pitcher J A; Patton W A; Moss J; Vaughan M; Lefkowitz R J
beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(24):14082-7.
1998: Lin F T; Daaka Y; Lefkowitz R J
beta-arrestins regulate mitogenic signaling and clathrin-mediated endocytosis of the insulin-like growth factor I receptor.
The Journal of biological chemistry 1998;273(48):31640-3.
1998: Stoffel R H; Inglese J; Macrae A D; Lefkowitz R J; Premont R T
Palmitoylation increases the kinase activity of the G protein-coupled receptor kinase, GRK6.
Biochemistry 1998;37(46):16053-9.
1998: Iaccarino G; Tomhave E D; Lefkowitz R J; Koch W J
Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by beta-adrenergic receptor stimulation and blockade.
Circulation 1998;98(17):1783-9.
1998: Davies M G; Huynh T T; Fulton G J; Lefkowitz R J; Svendsen E; Hagen P O; Koch W J
G protein signaling and vein graft intimal hyperplasia: reduction of intimal hyperplasia in vein grafts by a Gbetagamma inhibitor suggests a major role of G protein signaling in lesion development.
Arteriosclerosis, thrombosis, and vascular biology 1998;18(8):1275-80.
1998: Freeman J L; De La Cruz E M; Pollard T D; Lefkowitz R J; Pitcher J A
Regulation of G protein-coupled receptor kinase 5 (GRK5) by actin.
The Journal of biological chemistry 1998;273(32):20653-7.
1998: Hall R A; Ostedgaard L S; Premont R T; Blitzer J T; Rahman N; Welsh M J; Lefkowitz R J
A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(15):8496-501.
1998: Lefkowitz R J
G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization.
The Journal of biological chemistry 1998;273(30):18677-80.
1998: Rockman H A; Choi D J; Akhter S A; Jaber M; Giros B; Lefkowitz R J; Caron M G; Koch W J
Control of myocardial contractile function by the level of beta-adrenergic receptor kinase 1 in gene-targeted mice.
The Journal of biological chemistry 1998;273(29):18180-4.
1998: Rockman H A; Chien K R; Choi D J; Iaccarino G; Hunter J J; Ross J; Lefkowitz R J; Koch W J
Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(12):7000-5.
1998: Gaballa M A; Peppel K; Lefkowitz R J; Aguirre M; Dolber P C; Pennock G D; Koch W J; Goldman S
Enhanced vasorelaxation by overexpression of beta 2-adrenergic receptors in large arteries.
Journal of molecular and cellular cardiology 1998;30(5):1037-45.
1998: Pitcher J A; Hall R A; Daaka Y; Zhang J; Ferguson S S; Hester S; Miller S; Caron M G; Lefkowitz R J; Barak L S
The G protein-coupled receptor kinase 2 is a microtubule-associated protein kinase that phosphorylates tubulin.
The Journal of biological chemistry 1998;273(20):12316-24.
1998: Hall R A; Premont R T; Chow C W; Blitzer J T; Pitcher J A; Claing A; Stoffel R H; Barak L S; Shenolikar S; Weinman E J; Grinstein S; Lefkowitz R J
The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange.
Nature 1998;392(6676):626-30.
1998: Akhter S A; Luttrell L M; Rockman H A; Iaccarino G; Lefkowitz R J; Koch W J
Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy.
Science (New York, N.Y.) 1998;280(5363):574-7.
1998: Kypson A P; Peppel K; Akhter S A; Lilly R E; Glower D D; Lefkowitz R J; Koch W J
Ex vivo adenovirus-mediated gene transfer to the adult rat heart.
The Journal of thoracic and cardiovascular surgery 1998;115(3):623-30.
1998: Daaka Y; Luttrell L M; Ahn S; Della Rocca G J; Ferguson S S; Caron M G; Lefkowitz R J
Essential role for G protein-coupled receptor endocytosis in the activation of mitogen-activated protein kinase.
The Journal of biological chemistry 1998;273(2):685-8.
1998: Pitcher J A; Freedman N J; Lefkowitz R J
G protein-coupled receptor kinases.
Annual review of biochemistry 1998;67():653-92.
1998: Koch W J; Lefkowitz R J; Milano C A; Akhter S A; Rockman H A
Myocardial overexpression of adrenergic receptors and receptor kinases.
Advances in pharmacology (San Diego, Calif.) 1998;42():502-6.
1998: Luttrell L M; van Biesen T; Hawes B E; Della Rocca G J; Luttrell D K; Lefkowitz R J
Regulation of mitogen-activated protein kinase pathways by catecholamine receptors.
Advances in pharmacology (San Diego, Calif.) 1998;42():466-70.
1998: Lefkowitz R J; Pitcher J; Krueger K; Daaka Y
Mechanisms of beta-adrenergic receptor desensitization and resensitization.
Advances in pharmacology (San Diego, Calif.) 1998;42():416-20.
1997: Luttrell L M; Daaka Y; Della Rocca G J; Lefkowitz R J
G protein-coupled receptors mediate two functionally distinct pathways of tyrosine phosphorylation in rat 1a fibroblasts. Shc phosphorylation and receptor endocytosis correlate with activation of Erk kinases.
The Journal of biological chemistry 1997;272(50):31648-56.
1997: Lin F T; Krueger K M; Kendall H E; Daaka Y; Fredericks Z L; Pitcher J A; Lefkowitz R J
Clathrin-mediated endocytosis of the beta-adrenergic receptor is regulated by phosphorylation/dephosphorylation of beta-arrestin1.
The Journal of biological chemistry 1997;272(49):31051-7.
1997: Daaka Y; Luttrell L M; Lefkowitz R J
Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A.
Nature 1997;390(6655):88-91.
1997: Akhter S A; Skaer C A; Kypson A P; McDonald P H; Peppel K C; Glower D D; Lefkowitz R J; Koch W J
Restoration of beta-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(22):12100-5.
1997: Peppel K; Boekhoff I; McDonald P; Breer H; Caron M G; Lefkowitz R J
G protein-coupled receptor kinase 3 (GRK3) gene disruption leads to loss of odorant receptor desensitization.
The Journal of biological chemistry 1997;272(41):25425-8.
1997: Akhter S A; Milano C A; Shotwell K F; Cho M C; Rockman H A; Lefkowitz R J; Koch W J
Transgenic mice with cardiac overexpression of alpha1B-adrenergic receptors. In vivo alpha1-adrenergic receptor-mediated regulation of beta-adrenergic signaling.
The Journal of biological chemistry 1997;272(34):21253-9.
1997: Della Rocca G J; van Biesen T; Daaka Y; Luttrell D K; Luttrell L M; Lefkowitz R J
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
The Journal of biological chemistry 1997;272(31):19125-32.
1997: Freedman N J; Ament A S; Oppermann M; Stoffel R H; Exum S T; Lefkowitz R J
Phosphorylation and desensitization of human endothelin A and B receptors. Evidence for G protein-coupled receptor kinase specificity.
The Journal of biological chemistry 1997;272(28):17734-43.
1997: Drazner M H; Koch W J; Lefkowitz R J
Potentiation of beta-adrenergic signaling by gene transfer.
Proceedings of the Association of American Physicians 1997;109(3):220-7.
1997: Ménard L; Ferguson S S; Zhang J; Lin F T; Lefkowitz R J; Caron M G; Barak L S
Synergistic regulation of beta2-adrenergic receptor sequestration: intracellular complement of beta-adrenergic receptor kinase and beta-arrestin determine kinetics of internalization.
Molecular pharmacology 1997;51(5):800-8.
1997: Stoffel R H; Pitcher J A; Lefkowitz R J
Targeting G protein-coupled receptor kinases to their receptor substrates.
The Journal of membrane biology 1997;157(1):1-8.
1997: Bittner H B; Chen E P; Milano C A; Lefkowitz R J; Van Trigt P
Functional analysis of myocardial performance in murine hearts overexpressing the human beta 2-adrenergic receptor.
Journal of molecular and cellular cardiology 1997;29(3):961-7.
1997: Daaka Y; Pitcher J A; Richardson M; Stoffel R H; Robishaw J D; Lefkowitz R J
Receptor and G betagamma isoform-specific interactions with G protein-coupled receptor kinases.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(6):2180-5.
1997: Luttrell L M; Della Rocca G J; van Biesen T; Luttrell D K; Lefkowitz R J
Gbetagamma subunits mediate Src-dependent phosphorylation of the epidermal growth factor receptor. A scaffold for G protein-coupled receptor-mediated Ras activation.
The Journal of biological chemistry 1997;272(7):4637-44.
1997: Boekhoff I; Touhara K; Danner S; Inglese J; Lohse M J; Breer H; Lefkowitz R J
Phosducin, potential role in modulation of olfactory signaling.
The Journal of biological chemistry 1997;272(7):4606-12.
1997: Drazner M H; Peppel K C; Dyer S; Grant A O; Koch W J; Lefkowitz R J
Potentiation of beta-adrenergic signaling by adenoviral-mediated gene transfer in adult rabbit ventricular myocytes.
The Journal of clinical investigation 1997;99(2):288-96.
1997: Krueger K M; Daaka Y; Pitcher J A; Lefkowitz R J
The role of sequestration in G protein-coupled receptor resensitization. Regulation of beta2-adrenergic receptor dephosphorylation by vesicular acidification.
The Journal of biological chemistry 1997;272(1):5-8.
1997: Samama P; Bond R A; Rockman H A; Milano C A; Lefkowitz R J
Ligand-induced overexpression of a constitutively active beta2-adrenergic receptor: pharmacological creation of a phenotype in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(1):137-41.
1997: Zhang J; Ferguson S S; Barak L S; Aber M J; Giros B; Lefkowitz R J; Caron M G
Molecular mechanisms of G protein-coupled receptor signaling: role of G protein-coupled receptor kinases and arrestins in receptor desensitization and resensitization.
Receptors & channels 1997;5(3-4):193-9.
1997: Luttrell L M; van Biesen T; Hawes B E; Koch W J; Krueger K M; Touhara K; Lefkowitz R J
G-protein-coupled receptors and their regulation: activation of the MAP kinase signaling pathway by G-protein-coupled receptors.
Advances in second messenger and phosphoprotein research 1997;31():263-77.

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