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Robert Lefkowitz

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Arun K Shukla; Dean P Staus; Prachi Tripathi-Shukla; Wei-Chou Tseng; Serdar Uysal; William I Weis; Kunhong Xiao; Aashish Manglik; Marcin Paduch; Rosana I Reis; Daniel Hilger; Li-Yin Huang; Brian K Kobilka; Akiko Koide; Shohei Koide; Anthony A Kossiakoff; Andrew C Kruse; Robert J Lefkowitz
Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide.
Makoto R Hara; Marc G Caron; Benjamin D Sachs; Robert J Lefkowitz
Pharmacological blockade of a β(2)AR-β-arrestin-1 signaling cascade prevents the accumulation of DNA damage in a behavioral stress model.
Alem W Kahsai; Seungkirl Ahn; Terrence G Oas; Sudarshan Rajagopal; arun shukla; Jinpeng Sun; Kunhong Xiao; Robert J Lefkowitz
Multiple ligand-specific conformations of the β2-adrenergic receptor.

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All Publications

2013: Arun K Shukla; Dean P Staus; Prachi Tripathi-Shukla; Wei-Chou Tseng; Serdar Uysal; William I Weis; Kunhong Xiao; Aashish Manglik; Marcin Paduch; Rosana I Reis; Daniel Hilger; Li-Yin Huang; Brian K Kobilka; Akiko Koide; Shohei Koide; Anthony A Kossiakoff; Andrew C Kruse; Robert J Lefkowitz
Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide.
Nature 2013;497(7447):137-41.
2013: Makoto R Hara; Marc G Caron; Benjamin D Sachs; Robert J Lefkowitz
Pharmacological blockade of a β(2)AR-β-arrestin-1 signaling cascade prevents the accumulation of DNA damage in a behavioral stress model.
Cell cycle (Georgetown, Tex.) 2013;12(2):219-24.
2011: Alem W Kahsai; Seungkirl Ahn; Terrence G Oas; Sudarshan Rajagopal; arun shukla; Jinpeng Sun; Kunhong Xiao; Robert J Lefkowitz
Multiple ligand-specific conformations of the β2-adrenergic receptor.
Nature chemical biology 2011;7(10):692-700.
2011: Makoto R Hara; Jeffrey J Kovacs; Christopher M Lam; Seungkirl Ahn; Derek R Duckett; Wayne Grant; Simon G Gregory; Sudarshan Rajagopal; Sudha K Shenoy; Ryan T Strachan; Aaron J Towers; Erin J Whalen; Barbara Williams; Kunhong Xiao; Robert J Lefkowitz
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1.
Nature 2011;477(7364):349-53.
2011: arun shukla; Kunhong Xiao; Robert J Lefkowitz
Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling.
Trends in biochemical sciences 2011;36(9):457-69.
2011: Sudha K Shenoy; Robert J Lefkowitz
β-Arrestin-mediated receptor trafficking and signal transduction.
Trends in pharmacological sciences 2011;32(9):521-33.
2011: Sudarshan Rajagopal; David H Rominger; Jonathan D Violin; Seungkirl Ahn; Scott M DeWire; William Gowen-MacDonald; Christopher M Lam; Robert J Lefkowitz
Quantifying ligand bias at seven-transmembrane receptors.
Molecular pharmacology 2011;80(3):367-77.
2011: Kelly N Nobles; Sudarshan Rajagopal; Sudha K Shenoy; arun shukla; Ryan T Strachan; Kunhong Xiao; Seungkirl Ahn; Erin A Bressler; Steven P Gygi; Makoto R Hara; Teng-Yi Huang; Christopher M Lam; Robert J Lefkowitz
Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin.
Science signaling 2011;4(185):ra51.
2011: Howard A Rockman; Robert J Lefkowitz
Introduction to the series on novel aspects of cardiovascular G-protein-coupled receptor signaling.
Circulation research 2011;109(2):202-4.
2011: Alysia Kern Lovgren; Jeffrey J Kovacs; Ting Xie; Erin N Potts; Yuejuan Li; W Michael Foster; Jiurong Liang; Eric B Meltzer; Dianhua Jiang; Robert J Lefkowitz; Paul W Noble
β-arrestin deficiency protects against pulmonary fibrosis in mice and prevents fibroblast invasion of extracellular matrix.
Science translational medicine 2011;3(74):74ra23.
2011: Erin J Whalen; Sudarshan Rajagopal; Robert J Lefkowitz
Therapeutic potential of β-arrestin- and G protein-biased agonists.
Trends in molecular medicine 2011;17(3):126-39.
2010: Kunhong Xiao; Jinpeng Sun; Jihee Kim; Sudarshan Rajagopal; Bo Zhai; Judit Villén; Wilhelm Haas; Jeffrey J Kovacs; arun shukla; Makoto R Hara; Marylens Hernandez; Alexander Lachmann; Shan Zhao; Yuan Lin; Yishan Cheng; Kensaku Mizuno; Avi Ma'ayan; Steven P Gygi; Robert J Lefkowitz
Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR).
Proceedings of the National Academy of Sciences of the United States of America 2010;107(34):15299-304.
2010: Sudarshan Rajagopal; Keshava Rajagopal; Robert J Lefkowitz
Teaching old receptors new tricks: biasing seven-transmembrane receptors.
Nature reviews. Drug discovery 2010;9(5):373-86.
2010: Sudarshan Rajagopal; Jihee Kim; Seungkirl Ahn; Stewart Craig; Christopher M Lam; Norma P Gerard; Craig Gerard; Robert J Lefkowitz
Beta-arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(2):628-32.
2009: Diane Gesty-Palmer; Pat Flannery; Ling Yuan; Leonor Corsino; Robert Spurney; Robert J Lefkowitz; Louis M Luttrell
A beta-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation.
Science translational medicine 2009;1(1):1ra1.
2009: Jeffrey J Kovacs; Makoto R Hara; Chandra L Davenport; Jihee Kim; Robert J Lefkowitz
Arrestin development: emerging roles for beta-arrestins in developmental signaling pathways.
Developmental cell 2009;17(4):443-58.
2008: Larry S Barak; Ali Salahpour; Xiaodong Zhang; Bernard Masri; Tatyana D Sotnikova; Amy J Ramsey; Jonathan D Violin; Robert J Lefkowitz; Marc G Caron; Raul R Gainetdinov
Pharmacological characterization of membrane-expressed human trace amine-associated receptor 1 (TAAR1) by a bioluminescence resonance energy transfer cAMP biosensor.
Molecular pharmacology 2008;74(3):585-94.
2008: Kentaro Ozawa; Erin J Whalen; Christopher D Nelson; Yuanyu Mu; Douglas T Hess; Robert J Lefkowitz; Jonathan S Stamler
S-nitrosylation of beta-arrestin regulates beta-adrenergic receptor trafficking.
Molecular cell 2008;31(3):395-405.
2008: Christopher D Nelson; Jeffrey J Kovacs; Kelly N Nobles; Erin J Whalen; Robert J Lefkowitz
Beta-arrestin scaffolding of phosphatidylinositol 4-phosphate 5-kinase Ialpha promotes agonist-stimulated sequestration of the beta2-adrenergic receptor.
The Journal of biological chemistry 2008;283(30):21093-101.
2008: arun shukla; Jonathan D Violin; Erin J Whalen; Diane Gesty-Palmer; Sudha K Shenoy; Robert J Lefkowitz
Distinct conformational changes in beta-arrestin report biased agonism at seven-transmembrane receptors.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(29):9988-93.
2008: Jihee Kim; Lisheng Zhang; Karsten Peppel; Jiao-Hui Wu; David A Zidar; Leigh Brian; Scott M DeWire; Sabrina T Exum; Robert J Lefkowitz; Neil J Freedman
Beta-arrestins regulate atherosclerosis and neointimal hyperplasia by controlling smooth muscle cell proliferation and migration.
Circulation research 2008;103(1):70-9.
2008: Jeffrey J Kovacs; Erin J Whalen; Renshui Liu; Kunhong Xiao; Jihee Kim; Minyong Chen; Jiangbo Wang; Wei Chen; Robert J Lefkowitz
Beta-arrestin-mediated localization of smoothened to the primary cilium.
Science (New York, N.Y.) 2008;320(5884):1777-81.
2008: arun shukla; Jin-Peng Sun; Robert J Lefkowitz
Crystallizing thinking about the beta2-adrenergic receptor.
Molecular pharmacology 2008;73(5):1333-8.
2008: Scott M DeWire; Jihee Kim; Erin J Whalen; Seungkirl Ahn; Minyong Chen; Robert J Lefkowitz
Beta-arrestin-mediated signaling regulates protein synthesis.
The Journal of biological chemistry 2008;283(16):10611-20.
2008: Robert J Lefkowitz
The annual ASCI meeting: does nostalgia have a future?
The Journal of clinical investigation 2008;118(4):1231-3.
2008: Matthew T Drake; Jonathan D Violin; Erin J Whalen; James W Wisler; Sudha K Shenoy; Robert J Lefkowitz
beta-arrestin-biased agonism at the beta2-adrenergic receptor.
The Journal of biological chemistry 2008;283(9):5669-76.
2008: Jonathan D Violin; Lisa M DiPilato; Necmettin Yildirim; Timothy C Elston; Jin Zhang; Robert J Lefkowitz
beta2-adrenergic receptor signaling and desensitization elucidated by quantitative modeling of real time cAMP dynamics.
The Journal of biological chemistry 2008;283(5):2949-61.
2008: Jean-Martin Beaulieu; Sébastien Marion; Ramona M Rodriguiz; Ivan O Medvedev; Tatyana D Sotnikova; Valentina Ghisi; William C Wetsel; Robert J Lefkowitz; Raul R Gainetdinov; Marc G Caron
A beta-arrestin 2 signaling complex mediates lithium action on behavior.
Cell 2008;132(1):125-36.
2007: James W Wisler; Scott M DeWire; Erin J Whalen; Jonathan D Violin; Matthew T Drake; Seungkirl Ahn; Sudha K Shenoy; Robert J Lefkowitz
A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(42):16657-62.
2007: Sudha K Shenoy; Larry S Barak; Kunhong Xiao; Seungkirl Ahn; Magali Berthouze; arun shukla; Louis M Luttrell; Robert J Lefkowitz
Ubiquitination of beta-arrestin links seven-transmembrane receptor endocytosis and ERK activation.
The Journal of biological chemistry 2007;282(40):29549-62.
2007: Takahisa Noma; Anthony Lemaire; Sathyamangla V Naga Prasad; Liza Barki-Harrington; Douglas G Tilley; Juhsien Chen; Philippe Le Corvoisier; Jonathan D Violin; Huijun Wei; Robert J Lefkowitz; Howard A Rockman
Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection.
The Journal of clinical investigation 2007;117(9):2445-58.
2007: Jonathan D Violin; Robert J Lefkowitz
Beta-arrestin-biased ligands at seven-transmembrane receptors.
Trends in pharmacological sciences 2007;28(8):416-22.
2007: Kelly N Nobles; Ziqiang Guan; Kunhong Xiao; Terrence G Oas; Robert J Lefkowitz
The active conformation of beta-arrestin1: direct evidence for the phosphate sensor in the N-domain and conformational differences in the active states of beta-arrestins1 and -2.
The Journal of biological chemistry 2007;282(29):21370-81.
2007: Kunhong Xiao; Daniel B McClatchy; arun shukla; Yang Zhao; Minyong Chen; Sudha K Shenoy; John R Yates; Robert J Lefkowitz
Functional specialization of beta-arrestin interactions revealed by proteomic analysis.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(29):12011-6.
2007: Erin J Whalen; Matthew W Foster; Akio Matsumoto; Kentaro Ozawa; Jonathan D Violin; Loretta G Que; Christopher D Nelson; Moran Benhar; Janelle R Keys; Howard A Rockman; Walter J Koch; Yehia A Daaka; Robert J Lefkowitz; Jonathan S Stamler
Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2.
Cell 2007;129(3):511-22.
2007: Robert J Lefkowitz
Seven transmembrane receptors: something old, something new.
Acta physiologica (Oxford, England) 2007;190(1):9-19.
2007: Leonard Girnita; Sudha K Shenoy; Bita Sehat; Radu Vasilcanu; Daiana Vasilcanu; Ada Girnita; Robert J Lefkowitz; Olle Larsson
Beta-arrestin and Mdm2 mediate IGF-1 receptor-stimulated ERK activation and cell cycle progression.
The Journal of biological chemistry 2007;282(15):11329-38.
2007: Robert J Lefkowitz
Seven transmembrane receptors: a brief personal retrospective.
Biochimica et biophysica acta 2007;1768(4):748-55.
2007: Christopher D Nelson; Stephen J Perry; Debra S Regier; Stephen M Prescott; Matthew K Topham; Robert J Lefkowitz
Targeting of diacylglycerol degradation to M1 muscarinic receptors by beta-arrestins.
Science (New York, N.Y.) 2007;315(5812):663-6.
2007: Scott M DeWire; Seungkirl Ahn; Robert J Lefkowitz; Sudha K Shenoy
Beta-arrestins and cell signaling.
Annual review of physiology 2007;69():483-510.
2006: Robert J Lefkowitz; Keshava Rajagopal; Erin J Whalen
New roles for beta-arrestins in cell signaling: not just for seven-transmembrane receptors.
Molecular cell 2006;24(5):643-52.
2006: Jonathan D Violin; Scott M DeWire; William G Barnes; Robert J Lefkowitz
G protein-coupled receptor kinase and beta-arrestin-mediated desensitization of the angiotensin II type 1A receptor elucidated by diacylglycerol dynamics.
The Journal of biological chemistry 2006;281(47):36411-9.
2006: Keshava Rajagopal; Erin J Whalen; Jonathan D Violin; Jonathan A Stiber; Paul B Rosenberg; Richard T Premont; Thomas M Coffman; Howard A Rockman; Robert J Lefkowitz
Beta-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(44):16284-9.
2006: Alison R Meloni; Gregory B Fralish; Patrick Kelly; Ali Salahpour; James Kenneth Chen; Robert J Wechsler-Reya; Robert J Lefkowitz; Marc G Caron
Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2.
Molecular and cellular biology 2006;26(20):7550-60.
2006: Matthew T Drake; Sudha K Shenoy; Robert J Lefkowitz
Trafficking of G protein-coupled receptors.
Circulation research 2006;99(6):570-82.
2006: Jonathan D Violin; Xiu-Rong Ren; Robert J Lefkowitz
G-protein-coupled receptor kinase specificity for beta-arrestin recruitment to the beta2-adrenergic receptor revealed by fluorescence resonance energy transfer.
The Journal of biological chemistry 2006;281(29):20577-88.
2006: Eric Reiter; Robert J Lefkowitz
GRKs and beta-arrestins: roles in receptor silencing, trafficking and signaling.
Trends in endocrinology and metabolism: TEM 2006;17(4):159-65.
2006: Diane Gesty-Palmer; Minyong Chen; Eric Reiter; Seungkirl Ahn; Christopher D Nelson; Shuntai Wang; Allen E Eckhardt; Conrad L Cowan; Robert F Spurney; Louis M Luttrell; Robert J Lefkowitz
Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation.
The Journal of biological chemistry 2006;281(16):10856-64.
2006: Sudha K Shenoy; Matthew T Drake; Christopher D Nelson; Daniel A Houtz; Kunhong Xiao; Srinivasan Madabushi; Eric Reiter; Richard T Premont; Olivier Lichtarge; Robert J Lefkowitz
beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor.
The Journal of biological chemistry 2006;281(2):1261-73.
2005: Keshava Rajagopal; Robert J Lefkowitz; Howard A Rockman
When 7 transmembrane receptors are not G protein-coupled receptors.
The Journal of clinical investigation 2005;115(11):2971-4.
2005: Jean-Martin Beaulieu; Tatyana D Sotnikova; Sébastien Marion; Robert J Lefkowitz; Raul R Gainetdinov; Marc G Caron
An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior.
Cell 2005;122(2):261-73.
2005: Leonard Girnita; Sudha K Shenoy; Bita Sehat; Radu Vasilcanu; Ada Girnita; Robert J Lefkowitz; Olle Larsson
{beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase.
The Journal of biological chemistry 2005;280(26):24412-9.
2005: Sandra Milasta; Nicholas A Evans; Laura Ormiston; Shelagh Wilson; Robert J Lefkowitz; Graeme Milligan
The sustainability of interactions between the orexin-1 receptor and beta-arrestin-2 is defined by a single C-terminal cluster of hydroxy amino acids and modulates the kinetics of ERK MAPK regulation.
The Biochemical journal 2005;387(Pt 3):573-84.
2005: Sudha K Shenoy; Robert J Lefkowitz
Receptor-specific ubiquitination of beta-arrestin directs assembly and targeting of seven-transmembrane receptor signalosomes.
The Journal of biological chemistry 2005;280(15):15315-24.
2005: Dacia L Hunton; William G Barnes; Jihee Kim; Xiu-Rong Ren; Jonathan D Violin; Eric Reiter; Graeme Milligan; Dhavalkumar D Patel; Robert J Lefkowitz
Beta-arrestin 2-dependent angiotensin II type 1A receptor-mediated pathway of chemotaxis.
Molecular pharmacology 2005;67(4):1229-36.
2005: William G Barnes; Eric Reiter; Jonathan D Violin; Xiu-Rong Ren; Graeme Milligan; Robert J Lefkowitz
beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation.
The Journal of biological chemistry 2005;280(9):8041-50.
2005: Hideo Tachibana; Sathyamangla V Naga Prasad; Robert J Lefkowitz; Walter J Koch; Howard A Rockman
Level of beta-adrenergic receptor kinase 1 inhibition determines degree of cardiac dysfunction after chronic pressure overload-induced heart failure.
Circulation 2005;111(5):591-7.
2005: Jihee Kim; Seungkirl Ahn; Xiu-Rong Ren; Erin J Whalen; Eric Reiter; Huijun Wei; Robert J Lefkowitz
Functional antagonism of different G protein-coupled receptor kinases for beta-arrestin-mediated angiotensin II receptor signaling.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(5):1442-7.
2005: Xiu-Rong Ren; Eric Reiter; Seungkirl Ahn; Jihee Kim; Wei Chen; Robert J Lefkowitz
Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(5):1448-53.
2005: Robert J Lefkowitz
Summary of Wenner-Gren international symposium receptor-receptor interactions among heptaspanning membrane receptors: from structure to function.
Journal of molecular neuroscience : MN 2005;26(2-3):293-4.
2004: Kunhong Xiao; Sudha K Shenoy; Kelly Nobles; Robert J Lefkowitz
Activation-dependent conformational changes in {beta}-arrestin 2.
The Journal of biological chemistry 2004;279(53):55744-53.
2004: Wei Chen; Xiu-Rong Ren; Christopher D Nelson; Larry S Barak; James Kenneth Chen; Philip A Beachy; Frederic J de Sauvage; Robert J Lefkowitz
Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2.
Science (New York, N.Y.) 2004;306(5705):2257-60.
2004: Negin P Martin; Erin J Whalen; Musa A Zamah; Kristen L Pierce; Robert J Lefkowitz
PKA-mediated phosphorylation of the beta1-adrenergic receptor promotes Gs/Gi switching.
Cellular signalling 2004;16(12):1397-403.
2004: Huijun Wei; Seungkirl Ahn; William G Barnes; Robert J Lefkowitz
Stable interaction between beta-arrestin 2 and angiotensin type 1A receptor is required for beta-arrestin 2-mediated activation of extracellular signal-regulated kinases 1 and 2.
The Journal of biological chemistry 2004;279(46):48255-61.
2004: Seungkirl Ahn; Sudha K Shenoy; Huijun Wei; Robert J Lefkowitz
Differential kinetic and spatial patterns of beta-arrestin and G protein-mediated ERK activation by the angiotensin II receptor.
The Journal of biological chemistry 2004;279(34):35518-25.
2004: Robert J Lefkowitz
Historical review: a brief history and personal retrospective of seven-transmembrane receptors.
Trends in pharmacological sciences 2004;25(8):413-22.
2004: D Scott Witherow; Tiffany garrison; William E Miller; Robert J Lefkowitz
beta-Arrestin inhibits NF-kappaB activity by means of its interaction with the NF-kappaB inhibitor IkappaBalpha.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(23):8603-7.
2004: Neil J Freedman; Robert J Lefkowitz
Anti-beta(1)-adrenergic receptor antibodies and heart failure: causation, not just correlation.
The Journal of clinical investigation 2004;113(10):1379-82.
2004: Robert J Lefkowitz; Erin J Whalen
beta-arrestins: traffic cops of cell signaling.
Current opinion in cell biology 2004;16(2):162-8.
2004: Seungkirl Ahn; Huijun Wei; Tiffany garrison; Robert J Lefkowitz
Reciprocal regulation of angiotensin receptor-activated extracellular signal-regulated kinases by beta-arrestins 1 and 2.
The Journal of biological chemistry 2004;279(9):7807-11.
2004: Julia K L Walker; Raul R Gainetdinov; D S Feldman; PK McFawn; Marc G Caron; Robert J Lefkowitz; Richard T Premont; John T Fisher
G protein-coupled receptor kinase 5 regulates airway responses induced by muscarinic receptor activation.
American journal of physiology. Lung cellular and molecular physiology 2004;286(2):L312-9.
2004: Raul R Gainetdinov; Richard T Premont; Laura M Bohn; Robert J Lefkowitz; Marc G Caron
Desensitization of G protein-coupled receptors and neuronal functions.
Annual review of neuroscience 2004;27():107-44.
2003: Thomas J Povsic; Trudy A Kohout; Robert J Lefkowitz
Beta-arrestin1 mediates insulin-like growth factor 1 (IGF-1) activation of phosphatidylinositol 3-kinase (PI3K) and anti-apoptosis.
The Journal of biological chemistry 2003;278(51):51334-9.
2003: Negin P Martin; Robert J Lefkowitz; Sudha K Shenoy
Regulation of V2 vasopressin receptor degradation by agonist-promoted ubiquitination.
The Journal of biological chemistry 2003;278(46):45954-9.
2003: Sudha K Shenoy; Robert J Lefkowitz
Multifaceted roles of beta-arrestins in the regulation of seven-membrane-spanning receptor trafficking and signalling.
The Biochemical journal 2003;375(Pt 3):503-15.
2003: Charlotte Vines; Chetana M Revankar; Diane C Maestas; Leah L LaRusch; Daniel F Cimino; Trudy A Kohout; Robert J Lefkowitz; Eric R Prossnitz
N-formyl peptide receptors internalize but do not recycle in the absence of arrestins.
The Journal of biological chemistry 2003;278(43):41581-4.
2003: Huijun Wei; Seungkirl Ahn; Sudha K Shenoy; Sadashiva Karnik; László Hunyady; Louis M Luttrell; Robert J Lefkowitz
Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(19):10782-7.
2003: Antonio Rapacciuolo; Shayela Suvarna; Liza Barki-Harrington; Louis M Luttrell; Mei Cong; Robert J Lefkowitz; Howard A Rockman
Protein kinase A and G protein-coupled receptor kinase phosphorylation mediates beta-1 adrenergic receptor endocytosis through different pathways.
The Journal of biological chemistry 2003;278(37):35403-11.
2003: Wei Chen; Kellye Kirkbride; Tam How; Christopher D Nelson; Jinyao Mo; Joshua P Frederick; Xiao-Fan Wang; Robert J Lefkowitz; Gerard C Blobe
Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signaling.
Science (New York, N.Y.) 2003;301(5638):1394-7.
2003: Wei Chen; Derk ten Berge; Jeff Brown; Seungkirl Ahn; Liaoyuan A Hu; William E Miller; Marc G Caron; Larry S Barak; Roel Nusse; Robert J Lefkowitz
Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4.
Science (New York, N.Y.) 2003;301(5638):1391-4.
2003: Julia K L Walker; Alan M Fong; Barbara L Lawson; Jordan D Savov; Dhavalkumar D Patel; David A Schwartz; Robert J Lefkowitz
Beta-arrestin-2 regulates the development of allergic asthma.
The Journal of clinical investigation 2003;112(4):566-74.
2003: Liaoyuan A Hu; Wei Chen; Negin P Martin; Erin J Whalen; Richard T Premont; Robert J Lefkowitz
GIPC interacts with the beta1-adrenergic receptor and regulates beta1-adrenergic receptor-mediated ERK activation.
The Journal of biological chemistry 2003;278(28):26295-301.
2003: William E Miller; Daniel A Houtz; Christopher D Nelson; Pappachan Kolattukudy; Robert J Lefkowitz
G-protein-coupled receptor (GPCR) kinase phosphorylation and beta-arrestin recruitment regulate the constitutive signaling activity of the human cytomegalovirus US28 GPCR.
The Journal of biological chemistry 2003;278(24):21663-71.
2003: David T Lodowski; Julie A Pitcher; W Darrell Capel; Robert J Lefkowitz; John J G Tesmer
Keeping G proteins at bay: a complex between G protein-coupled receptor kinase 2 and Gbetagamma.
Science (New York, N.Y.) 2003;300(5623):1256-62.
2003: David T Lodowski; Jennifer F Barnhill; Julie A Pitcher; W Darrell Capel; Robert J Lefkowitz; John J G Tesmer
Purification, crystallization and preliminary X-ray diffraction studies of a complex between G protein-coupled receptor kinase 2 and Gbeta1gamma2.
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 5):936-9.
2003: Raul R Gainetdinov; Laura M Bohn; Tatyana D Sotnikova; Michel Cyr; Aki Laakso; Alexander D Macrae; Gonzalo E Torres; Kyeong Man Kim; Robert J Lefkowitz; Marc G Caron; Richard T Premont
Dopaminergic supersensitivity in G protein-coupled receptor kinase 6-deficient mice.
Neuron 2003;38(2):291-303.
2003: Sudha K Shenoy; Robert J Lefkowitz
Trafficking patterns of beta-arrestin and G protein-coupled receptors determined by the kinetics of beta-arrestin deubiquitination.
The Journal of biological chemistry 2003;278(16):14498-506.
2003: Akira Tohgo; Eric W Choy; Diane Gesty-Palmer; Kristen L Pierce; Stephane Laporte; Robert H Oakley; Marc G Caron; Robert J Lefkowitz; Louis M Luttrell
The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation.
The Journal of biological chemistry 2003;278(8):6258-67.
2003: Seungkirl Ahn; Christopher D Nelson; Tiffany garrison; William E Miller; Robert J Lefkowitz
Desensitization, internalization, and signaling functions of beta-arrestins demonstrated by RNA interference.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(4):1740-4.
2003: George S Baillie; Arvind Sood; Ian McPhee; Irene Gall; Stephen J Perry; Robert J Lefkowitz; Miles D Houslay
beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(3):940-5.
2003: Trudy A Kohout; Robert J Lefkowitz
Regulation of G protein-coupled receptor kinases and arrestins during receptor desensitization.
Molecular pharmacology 2003;63(1):9-18.
2002: Aylin C Hanyaloglu; Ruth M Seeber; Trudy A Kohout; Robert J Lefkowitz; Karin A Eidne
Homo- and hetero-oligomerization of thyrotropin-releasing hormone (TRH) receptor subtypes. Differential regulation of beta-arrestins 1 and 2.
The Journal of biological chemistry 2002;277(52):50422-30.
2002: Laura M Bohn; Robert J Lefkowitz; Marc G Caron
Differential mechanisms of morphine antinociceptive tolerance revealed in (beta)arrestin-2 knock-out mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(23):10494-500.
2002: Robert J Lefkowitz; Kristen L Pierce; Louis M Luttrell
Dancing with different partners: protein kinase a phosphorylation of seven membrane-spanning receptors regulates their G protein-coupling specificity.
Molecular pharmacology 2002;62(5):971-4.
2002: Stephen J Perry; George S Baillie; Trudy A Kohout; Ian McPhee; Maria M Magiera; Kok Long Ang; William E Miller; Alison J McLean; Marco Conti; Miles D Houslay; Robert J Lefkowitz
Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins.
Science (New York, N.Y.) 2002;298(5594):834-6.
2002: Jennifer L R Freeman; Philippe Gonzalo; Julie A Pitcher; Audrey Claing; Jean-Pierre Lavergne; Jean-Paul Reboud; Robert J Lefkowitz
Beta 2-adrenergic receptor stimulated, G protein-coupled receptor kinase 2 mediated, phosphorylation of ribosomal protein P2.
Biochemistry 2002;41(42):12850-7.
2002: Kristen L Pierce; Richard T Premont; Robert J Lefkowitz
Seven-transmembrane receptors.
Nature reviews. Molecular cell biology 2002;3(9):639-50.
2002: Fang-Tsyr Lin; Wei Chen; Sudha Shenoy; Mei Cong; Sabrina T Exum; Robert J Lefkowitz
Phosphorylation of beta-arrestin2 regulates its function in internalization of beta(2)-adrenergic receptors.
Biochemistry 2002;41(34):10692-9.
2002: A Musa Zamah; Martha Delahunty; Louis M Luttrell; Robert J Lefkowitz
Protein kinase A-mediated phosphorylation of the beta 2-adrenergic receptor regulates its coupling to Gs and Gi. Demonstration in a reconstituted system.
The Journal of biological chemistry 2002;277(34):31249-56.
2002: Seungkirl Ahn; Jihee Kim; Carmen Lucaveche; Mary C Reedy; Louis M Luttrell; Robert J Lefkowitz; Yehia A Daaka
Src-dependent tyrosine phosphorylation regulates dynamin self-assembly and ligand-induced endocytosis of the epidermal growth factor receptor.
The Journal of biological chemistry 2002;277(29):26642-51.
2002: Andrea D Eckhart; Richard C Fentzke; John J Lepore; Roberto Lang; Hua Lin; Robert J Lefkowitz; Walter J Koch; Jeffrey M Leiden
Inhibition of betaARK1 restores impaired biochemical beta-adrenergic receptor responsiveness but does not rescue CREB(A133) induced cardiomyopathy.
Journal of molecular and cellular cardiology 2002;34(6):669-77.
2002: Alan M Fong; Richard T Premont; Ricardo M Richardson; Yen-Rei A Yu; Robert J Lefkowitz; Dhavalkumar D Patel
Defective lymphocyte chemotaxis in beta-arrestin2- and GRK6-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(11):7478-83.
2002: Akira Tohgo; Kristen L Pierce; Eric W Choy; Robert J Lefkowitz; Louis M Luttrell
beta-Arrestin scaffolding of the ERK cascade enhances cytosolic ERK activity but inhibits ERK-mediated transcription following angiotensin AT1a receptor stimulation.
The Journal of biological chemistry 2002;277(11):9429-36.
2002: Stephen J Perry; Robert J Lefkowitz
Arresting developments in heptahelical receptor signaling and regulation.
Trends in cell biology 2002;12(3):130-8.
2002: Audrey Claing; Stephane Laporte; Marc G Caron; Robert J Lefkowitz
Endocytosis of G protein-coupled receptors: roles of G protein-coupled receptor kinases and beta-arrestin proteins.
Progress in neurobiology 2002;66(2):61-79.
2002: Louis M Luttrell; Robert J Lefkowitz
The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signals.
Journal of cell science 2002;115(Pt 3):455-65.
2002: Liaoyuan A Hu; Wei Chen; Richard T Premont; Mei Cong; Robert J Lefkowitz
G protein-coupled receptor kinase 5 regulates beta 1-adrenergic receptor association with PSD-95.
The Journal of biological chemistry 2002;277(2):1607-13.
2002: May M Paing; Amy B Stutts; Trudy A Kohout; Robert J Lefkowitz; JoAnn Trejo
beta -Arrestins regulate protease-activated receptor-1 desensitization but not internalization or Down-regulation.
The Journal of biological chemistry 2002;277(2):1292-300.
2002: Howard A Rockman; Walter J Koch; Robert J Lefkowitz
Seven-transmembrane-spanning receptors and heart function.
Nature 2002;415(6868):206-12.
2001: Wei Chen; Liaoyuan A Hu; M V Semenov; S Yanagawa; A Kikuchi; Robert J Lefkowitz; William E Miller
beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(26):14889-94.
2001: Mei Cong; Stephen J Perry; Liaoyuan A Hu; Phyllis I Hanson; Audrey Claing; Robert J Lefkowitz
Binding of the beta2 adrenergic receptor to N-ethylmaleimide-sensitive factor regulates receptor recycling.
The Journal of biological chemistry 2001;276(48):45145-52.
2001: Trudy A Kohout; Hideyuki Takaoka; Patricia McDonald; Stephen J Perry; Lan Mao; Robert J Lefkowitz; Howard A Rockman
Augmentation of cardiac contractility mediated by the human beta(3)-adrenergic receptor overexpressed in the hearts of transgenic mice.
Circulation 2001;104(20):2485-91.
2001: Sudha K Shenoy; Patricia McDonald; Trudy A Kohout; Robert J Lefkowitz
Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin.
Science (New York, N.Y.) 2001;294(5545):1307-13.
2001: Audrey Claing; Wei Chen; William E Miller; Nicolas Vitale; Joel Moss; Richard T Premont; Robert J Lefkowitz
beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis.
The Journal of biological chemistry 2001;276(45):42509-13.
2001: Robert J Lefkowitz
2001: An AAP (Association of American Physicians) odyssey.
The Journal of clinical investigation 2001;108(7):s9-s13.
2001: Patricia McDonald; Robert J Lefkowitz
Beta-Arrestins: new roles in regulating heptahelical receptors' functions.
Cellular signalling 2001;13(10):683-9.
2001: Kristen L Pierce; Robert J Lefkowitz
Classical and new roles of beta-arrestins in the regulation of G-protein-coupled receptors.
Nature reviews. Neuroscience 2001;2(10):727-33.
2001: guido iaccarino; Janelle R Keys; Antonio Rapacciuolo; KF Shotwell; Robert J Lefkowitz; Howard A Rockman; Walter J Koch
Regulation of myocardial betaARK1 expression in catecholamine-induced cardiac hypertrophy in transgenic mice overexpressing alpha1B-adrenergic receptors.
Journal of the American College of Cardiology 2001;38(2):534-40.
2001: William E Miller; Patricia McDonald; S F Cai; ME Field; Roger J Davis; Robert J Lefkowitz
Identification of a motif in the carboxyl terminus of beta -arrestin2 responsible for activation of JNK3.
The Journal of biological chemistry 2001;276(30):27770-7.
2001: Kristen L Pierce; Akira Tohgo; Seungkirl Ahn; ME Field; Louis M Luttrell; Robert J Lefkowitz
Epidermal growth factor (EGF) receptor-dependent ERK activation by G protein-coupled receptors: a co-culture system for identifying intermediates upstream and downstream of heparin-binding EGF shedding.
The Journal of biological chemistry 2001;276(25):23155-60.
2001: V B Harding; L R Jones; Robert J Lefkowitz; Walter J Koch; Howard A Rockman
Cardiac beta ARK1 inhibition prolongs survival and augments beta blocker therapy in a mouse model of severe heart failure.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(10):5809-14.
2001: Mei Cong; Stephen J Perry; Fang-Tsyr Lin; ID Fraser; Liaoyuan A Hu; Wei Chen; Julie A Pitcher; John D Scott; Robert J Lefkowitz
Regulation of membrane targeting of the G protein-coupled receptor kinase 2 by protein kinase A and its anchoring protein AKAP79.
The Journal of biological chemistry 2001;276(18):15192-9.
2001: William E Miller; Robert J Lefkowitz
Expanding roles for beta-arrestins as scaffolds and adapters in GPCR signaling and trafficking.
Current opinion in cell biology 2001;13(2):139-45.
2001: Kristen L Pierce; Louis M Luttrell; Robert J Lefkowitz
New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades.
Oncogene 2001;20(13):1532-9.
2001: Ashish S Shah; David C White; Sitaram M Emani; Alan P Kypson; R Eric Lilly; Katrina Wilson; Donald D Glower; Robert J Lefkowitz; Walter J Koch
In vivo ventricular gene delivery of a beta-adrenergic receptor kinase inhibitor to the failing heart reverses cardiac dysfunction.
Circulation 2001;103(9):1311-6.
2001: Louis M Luttrell; F L Roudabush; Eric W Choy; William E Miller; ME Field; Kristen L Pierce; Robert J Lefkowitz
Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(5):2449-54.
2001: William E Miller; Robert J Lefkowitz
Arrestins as signaling molecules involved in apoptotic pathways: a real eye opener.
Science's STKE : signal transduction knowledge environment 2001;2001(69):pe1.
2001: Trudy A Kohout; F S Lin; Stephen J Perry; D A Conner; Robert J Lefkowitz
beta-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(4):1601-6.
2000: Wenhong Cao; Louis M Luttrell; Alexander Medvedev; Kristen L Pierce; Kiefer W Daniel; TM Dixon; Robert J Lefkowitz; Sheila Collins
Direct binding of activated c-Src to the beta 3-adrenergic receptor is required for MAP kinase activation.
The Journal of biological chemistry 2000;275(49):38131-4.
2000: Liaoyuan A Hu; Y Tang; William E Miller; Mei Cong; A G Lau; Robert J Lefkowitz; RA Hall
beta 1-adrenergic receptor association with PSD-95. Inhibition of receptor internalization and facilitation of beta 1-adrenergic receptor interaction with N-methyl-D-aspartate receptors.
The Journal of biological chemistry 2000;275(49):38659-66.
2000: Laura M Bohn; Raul R Gainetdinov; Fang-Tsyr Lin; Robert J Lefkowitz; Marc G Caron
Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence.
Nature 2000;408(6813):720-3.
2000: Patricia McDonald; Chi-Wing Chow; William E Miller; Stephane Laporte; ME Field; Fang-Tsyr Lin; Roger J Davis; Robert J Lefkowitz
Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3.
Science (New York, N.Y.) 2000;290(5496):1574-7.
2000: Stuart Maudsley; A Musa Zamah; N Rahman; Jeremy T Blitzer; Louis M Luttrell; Robert J Lefkowitz; RA Hall
Platelet-derived growth factor receptor association with Na(+)/H(+) exchanger regulatory factor potentiates receptor activity.
Molecular and cellular biology 2000;20(22):8352-63.
2000: Ashish S Shah; David C White; O Tai; Jonathan A Hata; Kenneth H Wilson; Anne M Pippen; Alan P Kypson; Donald D Glower; Robert J Lefkowitz; Walter J Koch
Adenovirus-mediated genetic manipulation of the myocardial beta-adrenergic signaling system in transplanted hearts.
The Journal of thoracic and cardiovascular surgery 2000;120(3):581-8.
2000: Richard T Premont; Audrey Claing; Nicolas Vitale; Stephen J Perry; Robert J Lefkowitz
The GIT family of ADP-ribosylation factor GTPase-activating proteins. Functional diversity of GIT2 through alternative splicing.
The Journal of biological chemistry 2000;275(29):22373-80.
2000: Robert J Lefkowitz
The superfamily of heptahelical receptors.
Nature cell biology 2000;2(7):E133-6.
2000: Jennifer L R Freeman; Julie A Pitcher; X Li; Vann Bennett; Robert J Lefkowitz
alpha-Actinin is a potent regulator of G protein-coupled receptor kinase activity and substrate specificity in vitro.
FEBS letters 2000;473(3):280-4.
2000: David C White; Jonathan A Hata; Ashish S Shah; Donald D Glower; Robert J Lefkowitz; Walter J Koch
Preservation of myocardial beta-adrenergic receptor signaling delays the development of heart failure after myocardial infarction.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(10):5428-33.
2000: Nicolas Vitale; WA Patton; Joel Moss; Martha Vaughan; Robert J Lefkowitz; Richard T Premont
GIT proteins, A novel family of phosphatidylinositol 3,4, 5-trisphosphate-stimulated GTPase-activating proteins for ARF6.
The Journal of biological chemistry 2000;275(18):13901-6.
2000: William E Miller; Stuart Maudsley; Seungkirl Ahn; K D Khan; Louis M Luttrell; Robert J Lefkowitz
beta-arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC. Role of beta-arrestin1-dependent targeting of c-SRC in receptor endocytosis.
The Journal of biological chemistry 2000;275(15):11312-9.
2000: ID Fraser; Mei Cong; J Kim; E N Rollins; Yehia A Daaka; Robert J Lefkowitz; John D Scott
Assembly of an A kinase-anchoring protein-beta(2)-adrenergic receptor complex facilitates receptor phosphorylation and signaling.
Current biology : CB 2000;10(7):409-12.
2000: Stuart Maudsley; Kristen L Pierce; A Musa Zamah; William E Miller; Seungkirl Ahn; Yehia A Daaka; Robert J Lefkowitz; Louis M Luttrell
The beta(2)-adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptor.
The Journal of biological chemistry 2000;275(13):9572-80.
2000: Kristen L Pierce; Stuart Maudsley; Yehia A Daaka; Louis M Luttrell; Robert J Lefkowitz
Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(4):1489-94.
2000: Audrey Claing; Stephen J Perry; M Achiriloaie; Julia K L Walker; Joseph P Albanesi; Robert J Lefkowitz; Richard T Premont
Multiple endocytic pathways of G protein-coupled receptors delineated by GIT1 sensitivity.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(3):1119-24.
2000: Ashish S Shah; R Eric Lilly; Alan P Kypson; O Tai; Jonathan A Hata; Anne M Pippen; Scott Silvestry; Robert J Lefkowitz; Donald D Glower; Walter J Koch
Intracoronary adenovirus-mediated delivery and overexpression of the beta(2)-adrenergic receptor in the heart : prospects for molecular ventricular assistance.
Circulation 2000;101(4):408-14.
2000: Andrea D Eckhart; S J Duncan; Raymond B Penn; J L Benovic; Robert J Lefkowitz; Walter J Koch
Hybrid transgenic mice reveal in vivo specificity of G protein-coupled receptor kinases in the heart.
Circulation research 2000;86(1):43-50.
2000: Walter J Koch; Robert J Lefkowitz; Howard A Rockman
Functional consequences of altering myocardial adrenergic receptor signaling.
Annual review of physiology 2000;62():237-60.
1999: Laura M Bohn; Robert J Lefkowitz; Raul R Gainetdinov; Karsten Peppel; Marc G Caron; Fang-Tsyr Lin
Enhanced morphine analgesia in mice lacking beta-arrestin 2.
Science (New York, N.Y.) 1999;286(5449):2495-8.
1999: Julie A Pitcher; John J G Tesmer; Jennifer L R Freeman; W Darrell Capel; W C Stone; Robert J Lefkowitz
Feedback inhibition of G protein-coupled receptor kinase 2 (GRK2) activity by extracellular signal-regulated kinases.
The Journal of biological chemistry 1999;274(49):34531-4.
1999: Raul R Gainetdinov; Laura M Bohn; Julia K L Walker; Stephane Laporte; Alexander D Macrae; Marc G Caron; Robert J Lefkowitz; Richard T Premont
Muscarinic supersensitivity and impaired receptor desensitization in G protein-coupled receptor kinase 5-deficient mice.
Neuron 1999;24(4):1029-36.
1999: Y Tang; Liaoyuan A Hu; William E Miller; N Ringstad; RA Hall; Julie A Pitcher; Pietro De Camilli; Robert J Lefkowitz
Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the beta1-adrenergic receptor.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(22):12559-64.
1999: Richard T Premont; Alexander D Macrae; S A Aparicio; H E Kendall; J E Welch; Robert J Lefkowitz
The GRK4 subfamily of G protein-coupled receptor kinases. Alternative splicing, gene organization, and sequence conservation.
The Journal of biological chemistry 1999;274(41):29381-9.
1999: guido iaccarino; Robert J Lefkowitz; Walter J Koch
Myocardial G protein-coupled receptor kinases: implications for heart failure therapy.
Proceedings of the Association of American Physicians 1999;111(5):399-405.
1999: RA Hall; Robert F Spurney; Richard T Premont; N Rahman; Jeremy T Blitzer; Julie A Pitcher; Robert J Lefkowitz
G protein-coupled receptor kinase 6A phosphorylates the Na(+)/H(+) exchanger regulatory factor via a PDZ domain-mediated interaction.
The Journal of biological chemistry 1999;274(34):24328-34.
1999: SA Akhter; Andrea D Eckhart; Howard A Rockman; KF Shotwell; Robert J Lefkowitz; Walter J Koch
In vivo inhibition of elevated myocardial beta-adrenergic receptor kinase activity in hybrid transgenic mice restores normal beta-adrenergic signaling and function.
Circulation 1999;100(6):648-53.
1999: Alan P Kypson; SC Hendrickson; SA Akhter; Katrina Wilson; P McDonald; R Eric Lilly; Paul C Dolber; Donald D Glower; Robert J Lefkowitz; Walter J Koch
Adenovirus-mediated gene transfer of the beta2-adrenergic receptor to donor hearts enhances cardiac function.
Gene therapy 1999;6(7):1298-304.
1999: JP Maurice; Jonathan A Hata; Ashish S Shah; David C White; Patricia McDonald; Paul C Dolber; Kenneth H Wilson; Robert J Lefkowitz; Donald D Glower; Walter J Koch
Enhancement of cardiac function after adenoviral-mediated in vivo intracoronary beta2-adrenergic receptor gene delivery.
The Journal of clinical investigation 1999;104(1):21-9.
1999: Fang-Tsyr Lin; William E Miller; Louis M Luttrell; Robert J Lefkowitz
Feedback regulation of beta-arrestin1 function by extracellular signal-regulated kinases.
The Journal of biological chemistry 1999;274(23):15971-4.
1999: GJ Della Rocca; Stuart Maudsley; Yehia A Daaka; Robert J Lefkowitz; Louis M Luttrell
Pleiotropic coupling of G protein-coupled receptors to the mitogen-activated protein kinase cascade. Role of focal adhesions and receptor tyrosine kinases.
The Journal of biological chemistry 1999;274(20):13978-84.
1999: Patricia McDonald; N L Cote; Fang-Tsyr Lin; Richard T Premont; Julie A Pitcher; Robert J Lefkowitz
Identification of NSF as a beta-arrestin1-binding protein. Implications for beta2-adrenergic receptor regulation.
The Journal of biological chemistry 1999;274(16):10677-80.
1999: Louis M Luttrell; Yehia A Daaka; Robert J Lefkowitz
Regulation of tyrosine kinase cascades by G-protein-coupled receptors.
Current opinion in cell biology 1999;11(2):177-83.
1999: Julia K L Walker; Karsten Peppel; Robert J Lefkowitz; Marc G Caron; John T Fisher
Altered airway and cardiac responses in mice lacking G protein-coupled receptor kinase 3.
The American journal of physiology 1999;276(4 Pt 2):R1214-21.
1999: guido iaccarino; L A Smithwick; Robert J Lefkowitz; Walter J Koch
Targeting Gbeta gamma signaling in arterial vascular smooth muscle proliferation: a novel strategy to limit restenosis.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(7):3945-50.
1999: GJ Della Rocca; Yurii V Mukhin; Maria N Garnovskaya; Yehia A Daaka; G J Clark; Louis M Luttrell; Robert J Lefkowitz; John R Raymond
Serotonin 5-HT1A receptor-mediated Erk activation requires calcium/calmodulin-dependent receptor endocytosis.
The Journal of biological chemistry 1999;274(8):4749-53.
1999: Louis M Luttrell; Stephen S G Ferguson; Yehia A Daaka; William E Miller; Stuart Maudsley; GJ Della Rocca; F Lin; H Kawakatsu; Kiyoshi Owada; Deidre K. Luttrell; Marc G Caron; Robert J Lefkowitz
Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes.
Science (New York, N.Y.) 1999;283(5402):655-61.
1999: Seungkirl Ahn; Stuart Maudsley; Louis M Luttrell; Robert J Lefkowitz; Yehia A Daaka
Src-mediated tyrosine phosphorylation of dynamin is required for beta2-adrenergic receptor internalization and mitogen-activated protein kinase signaling.
The Journal of biological chemistry 1999;274(3):1185-8.
1999: guido iaccarino; Paul C Dolber; Robert J Lefkowitz; Walter J Koch
Bbeta-adrenergic receptor kinase-1 levels in catecholamine-induced myocardial hypertrophy: regulation by beta- but not alpha1-adrenergic stimulation.
Hypertension 1999;33(1 Pt 2):396-401.
1998: Fang-Tsyr Lin; Yehia A Daaka; Robert J Lefkowitz
beta-arrestins regulate mitogenic signaling and clathrin-mediated endocytosis of the insulin-like growth factor I receptor.
The Journal of biological chemistry 1998;273(48):31640-3.
1998: Richard T Premont; Audrey Claing; Nicolas Vitale; Jennifer L R Freeman; Julie A Pitcher; WA Patton; Joel Moss; Martha Vaughan; Robert J Lefkowitz
beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(24):14082-7.
1998: RH Stoffel; James Inglese; Alexander D Macrae; Robert J Lefkowitz; Richard T Premont
Palmitoylation increases the kinase activity of the G protein-coupled receptor kinase, GRK6.
Biochemistry 1998;37(46):16053-9.
1998: guido iaccarino; E D Tomhave; Robert J Lefkowitz; Walter J Koch
Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by beta-adrenergic receptor stimulation and blockade.
Circulation 1998;98(17):1783-9.
1998: Jennifer L R Freeman; E M De La Cruz; T D Pollard; Robert J Lefkowitz; Julie A Pitcher
Regulation of G protein-coupled receptor kinase 5 (GRK5) by actin.
The Journal of biological chemistry 1998;273(32):20653-7.
1998: MG Davies; Tam T T Huynh; GJ Fulton; Robert J Lefkowitz; E Svendsen; Per-Otto Hagen; Walter J Koch
G protein signaling and vein graft intimal hyperplasia: reduction of intimal hyperplasia in vein grafts by a Gbetagamma inhibitor suggests a major role of G protein signaling in lesion development.
Arteriosclerosis, thrombosis, and vascular biology 1998;18(8):1275-80.
1998: Robert J Lefkowitz
G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization.
The Journal of biological chemistry 1998;273(30):18677-80.
1998: RA Hall; Lynda S Ostedgaard; Richard T Premont; Jeremy T Blitzer; N Rahman; Michael J Welsh; Robert J Lefkowitz
A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(15):8496-501.
1998: Howard A Rockman; DJ Choi; S A Akhter; M Jaber; Bruno GIROS; Robert J Lefkowitz; Marc G Caron; Walter J Koch
Control of myocardial contractile function by the level of beta-adrenergic receptor kinase 1 in gene-targeted mice.
The Journal of biological chemistry 1998;273(29):18180-4.
1998: Howard A Rockman; Kenneth R Chien; DJ Choi; guido iaccarino; JJ Hunter; John Ross; Robert J Lefkowitz; Walter J Koch
Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(12):7000-5.
1998: Julie A Pitcher; RA Hall; Yehia A Daaka; Jian Zhang; Stephen S G Ferguson; S Hester; S Miller; Marc G Caron; Robert J Lefkowitz; Larry S Barak
The G protein-coupled receptor kinase 2 is a microtubule-associated protein kinase that phosphorylates tubulin.
The Journal of biological chemistry 1998;273(20):12316-24.
1998: M A Gaballa; Karsten Peppel; Robert J Lefkowitz; M Aguirre; Paul C Dolber; G D Pennock; Walter J Koch; S Goldman
Enhanced vasorelaxation by overexpression of beta 2-adrenergic receptors in large arteries.
Journal of molecular and cellular cardiology 1998;30(5):1037-45.
1998: SA Akhter; Louis M Luttrell; Howard A Rockman; guido iaccarino; Robert J Lefkowitz; Walter J Koch
Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy.
Science (New York, N.Y.) 1998;280(5363):574-7.
1998: RA Hall; Richard T Premont; Chi-Wing Chow; Jeremy T Blitzer; Julie A Pitcher; Audrey Claing; RH Stoffel; Larry S Barak; Shirish Shenolikar; Edward J Weinman; S Grinstein; Robert J Lefkowitz
The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange.
Nature 1998;392(6676):626-30.
1998: Alan P Kypson; Karsten Peppel; SA Akhter; R Eric Lilly; Donald D Glower; Robert J Lefkowitz; Walter J Koch
Ex vivo adenovirus-mediated gene transfer to the adult rat heart.
The Journal of thoracic and cardiovascular surgery 1998;115(3):623-30.
1998: Yehia A Daaka; Louis M Luttrell; Seungkirl Ahn; GJ Della Rocca; Stephen S G Ferguson; Marc G Caron; Robert J Lefkowitz
Essential role for G protein-coupled receptor endocytosis in the activation of mitogen-activated protein kinase.
The Journal of biological chemistry 1998;273(2):685-8.
1998: J A Pitcher; N J Freedman; Robert J Lefkowitz
G protein-coupled receptor kinases.
Annual review of biochemistry 1998;67():653-92.
1998: Walter J Koch; Robert J Lefkowitz; Carmelo A Milano; SA Akhter; Howard A Rockman
Myocardial overexpression of adrenergic receptors and receptor kinases.
Advances in pharmacology (San Diego, Calif.) 1998;42():502-6.
1998: Louis M Luttrell; T van Biesen; B E Hawes; GJ Della Rocca; Deidre K. Luttrell; Robert J Lefkowitz
Regulation of mitogen-activated protein kinase pathways by catecholamine receptors.
Advances in pharmacology (San Diego, Calif.) 1998;42():466-70.
1998: Robert J Lefkowitz; Julie A Pitcher; K Krueger; Yehia A Daaka
Mechanisms of beta-adrenergic receptor desensitization and resensitization.
Advances in pharmacology (San Diego, Calif.) 1998;42():416-20.
1997: Louis M Luttrell; Yehia A Daaka; GJ Della Rocca; Robert J Lefkowitz
G protein-coupled receptors mediate two functionally distinct pathways of tyrosine phosphorylation in rat 1a fibroblasts. Shc phosphorylation and receptor endocytosis correlate with activation of Erk kinases.
The Journal of biological chemistry 1997;272(50):31648-56.
1997: Fang-Tsyr Lin; KM Krueger; H E Kendall; Yehia A Daaka; Z L Fredericks; Julie A Pitcher; Robert J Lefkowitz
Clathrin-mediated endocytosis of the beta-adrenergic receptor is regulated by phosphorylation/dephosphorylation of beta-arrestin1.
The Journal of biological chemistry 1997;272(49):31051-7.
1997: Yehia A Daaka; Louis M Luttrell; Robert J Lefkowitz
Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A.
Nature 1997;390(6655):88-91.
1997: SA Akhter; C A Skaer; Alan P Kypson; Patricia McDonald; Karsten Peppel; Donald D Glower; Robert J Lefkowitz; Walter J Koch
Restoration of beta-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(22):12100-5.
1997: Karsten Peppel; Ingrid Boekhoff; P McDonald; Heinz Breer; Marc G Caron; Robert J Lefkowitz
G protein-coupled receptor kinase 3 (GRK3) gene disruption leads to loss of odorant receptor desensitization.
The Journal of biological chemistry 1997;272(41):25425-8.
1997: SA Akhter; Carmelo A Milano; KF Shotwell; M C Cho; Howard A Rockman; Robert J Lefkowitz; Walter J Koch
Transgenic mice with cardiac overexpression of alpha1B-adrenergic receptors. In vivo alpha1-adrenergic receptor-mediated regulation of beta-adrenergic signaling.
The Journal of biological chemistry 1997;272(34):21253-9.
1997: GJ Della Rocca; T van Biesen; Yehia A Daaka; Deidre K. Luttrell; Louis M Luttrell; Robert J Lefkowitz
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
The Journal of biological chemistry 1997;272(31):19125-32.
1997: Neil J Freedman; A S Ament; M Oppermann; RH Stoffel; Sabrina T Exum; Robert J Lefkowitz
Phosphorylation and desensitization of human endothelin A and B receptors. Evidence for G protein-coupled receptor kinase specificity.
The Journal of biological chemistry 1997;272(28):17734-43.
1997: M H Drazner; Walter J Koch; Robert J Lefkowitz
Potentiation of beta-adrenergic signaling by gene transfer.
Proceedings of the Association of American Physicians 1997;109(3):220-7.
1997: L Ménard; Stephen S G Ferguson; Jian Zhang; Fang-Tsyr Lin; Robert J Lefkowitz; Marc G Caron; Larry S Barak
Synergistic regulation of beta2-adrenergic receptor sequestration: intracellular complement of beta-adrenergic receptor kinase and beta-arrestin determine kinetics of internalization.
Molecular pharmacology 1997;51(5):800-8.
1997: RH Stoffel; Julie A Pitcher; Robert J Lefkowitz
Targeting G protein-coupled receptor kinases to their receptor substrates.
The Journal of membrane biology 1997;157(1):1-8.
1997: Yehia A Daaka; Julie A Pitcher; M Richardson; RH Stoffel; J D Robishaw; Robert J Lefkowitz
Receptor and G betagamma isoform-specific interactions with G protein-coupled receptor kinases.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(6):2180-5.
1997: Hartmuth B Bittner; EP Chen; Carmelo A Milano; Robert J Lefkowitz; P Van Trigt
Functional analysis of myocardial performance in murine hearts overexpressing the human beta 2-adrenergic receptor.
Journal of molecular and cellular cardiology 1997;29(3):961-7.
1997: Louis M Luttrell; GJ Della Rocca; T van Biesen; Deidre K. Luttrell; Robert J Lefkowitz
Gbetagamma subunits mediate Src-dependent phosphorylation of the epidermal growth factor receptor. A scaffold for G protein-coupled receptor-mediated Ras activation.
The Journal of biological chemistry 1997;272(7):4637-44.
1997: Ingrid Boekhoff; K Touhara; S Danner; James Inglese; M J Lohse; Heinz Breer; Robert J Lefkowitz
Phosducin, potential role in modulation of olfactory signaling.
The Journal of biological chemistry 1997;272(7):4606-12.
1997: M H Drazner; Karsten Peppel; S Dyer; Augustus O Grant; Walter J Koch; Robert J Lefkowitz
Potentiation of beta-adrenergic signaling by adenoviral-mediated gene transfer in adult rabbit ventricular myocytes.
The Journal of clinical investigation 1997;99(2):288-96.
1997: P Samama; R A Bond; Howard A Rockman; Carmelo A Milano; Robert J Lefkowitz
Ligand-induced overexpression of a constitutively active beta2-adrenergic receptor: pharmacological creation of a phenotype in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(1):137-41.
1997: KM Krueger; Yehia A Daaka; Julie A Pitcher; Robert J Lefkowitz
The role of sequestration in G protein-coupled receptor resensitization. Regulation of beta2-adrenergic receptor dephosphorylation by vesicular acidification.
The Journal of biological chemistry 1997;272(1):5-8.
1997: Jian Zhang; Stephen S G Ferguson; Larry S Barak; M J Aber; Bruno GIROS; Robert J Lefkowitz; Marc G Caron
Molecular mechanisms of G protein-coupled receptor signaling: role of G protein-coupled receptor kinases and arrestins in receptor desensitization and resensitization.
Receptors & channels 1997;5(3-4):193-9.
1997: Louis M Luttrell; T van Biesen; B E Hawes; Walter J Koch; KM Krueger; K Touhara; Robert J Lefkowitz
G-protein-coupled receptors and their regulation: activation of the MAP kinase signaling pathway by G-protein-coupled receptors.
Advances in second messenger and phosphoprotein research 1997;31():263-77.