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Leo Lefrançois

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Damian L Turner; Kara L Bickham; Donna L Farber; Leo Lefrançois
Splenic priming of virus-specific CD8 T cells following influenza virus infection.
Tina O Bose; Evan R Jellison; Juliette Mouries; Quynh-Mai Pham; Christie M Ballantyne; Leo Lefrançois
CD11a regulates effector CD8 T cell differentiation and central memory development in response to infection with Listeria monocytogenes.
Daqi Xu; Hideo Yagita; Han-Hsuan Fu; Joshua J Obar; Jang-June Park; Koji Tamada; Leo Lefrançois
A potential new pathway for PD-L1 costimulation of the CD8-T cell response to Listeria monocytogenes infection.

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All Publications

2013: Damian L Turner; Kara L Bickham; Donna L Farber; Leo Lefrançois
Splenic priming of virus-specific CD8 T cells following influenza virus infection.
Journal of virology 2013;87(8):4496-506.
2013: Tina O Bose; Evan R Jellison; Juliette Mouries; Quynh-Mai Pham; Christie M Ballantyne; Leo Lefrançois
CD11a regulates effector CD8 T cell differentiation and central memory development in response to infection with Listeria monocytogenes.
Infection and immunity 2013;81(4):1140-51.
2013: Daqi Xu; Hideo Yagita; Han-Hsuan Fu; Joshua J Obar; Jang-June Park; Koji Tamada; Leo Lefrançois
A potential new pathway for PD-L1 costimulation of the CD8-T cell response to Listeria monocytogenes infection.
PloS one 2013;8(2):e56539.
2013: Linda S Cauley; Leo Lefrançois
Guarding the perimeter: protection of the mucosa by tissue-resident memory T cells.
Mucosal immunology 2013;6(1):14-23.
2012: Evan R Jellison; David A Blair; Elizabeth G Lingenheld; Lynn Puddington; Michael J Turner; Li Zu; Leo Lefrançois
Distinct mechanisms mediate naive and memory CD8 T-cell tolerance.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(52):21438-43.
2012: Brian S Sheridan; Leo Lefrançois
Isolation of mouse lymphocytes from small intestine tissues.
Current protocols in immunology / edited by John E. Coligan ... [et al.] 2012;Chapter 3():Unit3.19.
2012: Kamal M Khanna; Leo Lefrançois
B cells, not just for antibody anymore.
Immunity 2012;36(3):315-7.
2012: Sara L Colpitts; Caiying Guo; Joshua J Obar; Courtney R Plumlee; Thomas Stoklasek; Leo Lefrançois
Cutting edge: the role of IFN-α receptor and MyD88 signaling in induction of IL-15 expression in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(6):2483-7.
2011: Joshua J Obar; Quynh-Mai Pham; Brian S Sheridan; Julianne M Zickovich; David A Blair; Evan R Jellison; Leo Lefrançois
Pathogen-induced inflammatory environment controls effector and memory CD8+ T cell differentiation.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(10):4967-78.
2011: David A Blair; Tina O Bose; Keith R Bouchard; Linda S Cauley; Jeremy P McAleer; Quynh-Mai Pham; Damian L Turner; Anthony T Vella; Kristina J Williams; Leo Lefrançois
Duration of antigen availability influences the expansion and memory differentiation of T cells.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(5):2310-21.
2011: Brian S Sheridan; Leo Lefrançois
Regional and mucosal memory T cells.
Nature immunology 2011;12(6):485-91.
2011: Carol A Wu; Sara A Paveglio; Elizabeth G Lingenheld; Li Zhu; Leo Lefrançois; Lynn Puddington
Transmission of murine cytomegalovirus in breast milk: a model of natural infection in neonates.
Journal of virology 2011;85(10):5115-24.
2010: Thomas A Stoklasek; Sara L Colpitts; Henry M Smilowitz; Leo Lefrançois
MHC class I and TCR avidity control the CD8 T cell response to IL-15/IL-15Rα complex.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(11):6857-65.
2010: Brian S Sheridan; Leo Lefrançois
Intraepithelial lymphocytes: to serve and protect.
Current gastroenterology reports 2010;12(6):513-21.
2010: Joshua J Obar; Leo Lefrançois
Early events governing memory CD8+ T-cell differentiation.
International immunology 2010;22(8):619-25.
2010: Kamal M Khanna; David A Blair; Anthony T Vella; Stephen J McSorley; Sandip K Datta; Leo Lefrançois
T cell and APC dynamics in situ control the outcome of vaccination.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(1):239-52.
2010: Joshua J Obar; Leo Lefrançois
Early signals during CD8 T cell priming regulate the generation of central memory cells.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(1):263-72.
2010: Leo Lefrançois; Joshua J Obar
Once a killer, always a killer: from cytotoxic T cell to memory cell.
Immunological reviews 2010;235(1):206-18.
2010: Joshua J Obar; Michael J Molloy; Evan R Jellison; Thomas A Stoklasek; Weijun Zhang; Edward J Usherwood; Leo Lefrançois
CD4+ T cell regulation of CD25 expression controls development of short-lived effector CD8+ T cells in primary and secondary responses.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(1):193-8.
2010: Joshua J Obar; Leo Lefrançois
Memory CD8+ T cell differentiation.
Annals of the New York Academy of Sciences 2010;1183():251-66.
2008: Kamal Khanna; Carolina C Aguila; Jason M Redman; Jenny E Suarez-Ramirez; Leo Lefrançois; Linda S Cauley
In situ imaging reveals different responses by naïve and memory CD8 T cells to late antigen presentation by lymph node DC after influenza virus infection.
European journal of immunology 2008;38(12):3304-15.
2008: Michael J Turner; Evan R Jellison; Elizabeth G Lingenheld; Lynn Puddington; Leo Lefrançois
Avidity maturation of memory CD8 T cells is limited by self-antigen expression.
The Journal of experimental medicine 2008;205(8):1859-68.
2008: Joshua J Obar; Kamal Khanna; Leo Lefrançois
Endogenous naive CD8+ T cell precursor frequency regulates primary and memory responses to infection.
Immunity 2008;28(6):859-69.
2007: Jeremy P McAleer; David J Zammit; Leo Lefrançois; Robert J Rossi; Anthony T Vella
The lipopolysaccharide adjuvant effect on T cells relies on nonoverlapping contributions from the MyD88 pathway and CD11c+ cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(10):6524-35.
2007: Kamal Khanna; Jeffery T McNamara; Leo Lefrançois
In situ imaging of the endogenous CD8 T cell response to infection.
Science (New York, N.Y.) 2007;318(5847):116-20.
2007: David A Blair; Leo Lefrançois
Increased competition for antigen during priming negatively impacts the generation of memory CD4 T cells.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(38):15045-50.
2007: Amanda L Marzo; Hideo Yagita; Leo Lefrançois
Cutting edge: migration to nonlymphoid tissues results in functional conversion of central to effector memory CD8 T cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(1):36-40.
2007: Yi Yang; Bei Liu; Jie Dai; Pramod K Srivastava; David J Zammit; Leo Lefrançois; Zihai Li
Heat shock protein gp96 is a master chaperone for toll-like receptors and is important in the innate function of macrophages.
Immunity 2007;26(2):215-26.
2007: Damian L Turner; Linda S Cauley; Kamal Khanna; Leo Lefrançois
Persistent antigen presentation after acute vesicular stomatitis virus infection.
Journal of virology 2007;81(4):2039-46.
2006: Kimberly D Klonowski; Amanda L Marzo; Kristina J Williams; Seung-Joo Lee; Quynh-Mai Pham; Leo Lefrançois
CD8 T cell recall responses are regulated by the tissue tropism of the memory cell and pathogen.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(10):6738-46.
2006: Thomas Stoklasek; Kimberly Schluns; Leo Lefrançois
Combined IL-15/IL-15Ralpha immunotherapy maximizes IL-15 activity in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(9):6072-80.
2006: Juan E Moyron-Quiroz; Javier Rangel Moreno; Louise Hartson; Kim Kusser; Michael Tighe; Kimberly D Klonowski; Leo Lefrançois; Linda S Cauley; Allen G Harmsen; Frances E Lund; Troy D Randall
Persistence and responsiveness of immunologic memory in the absence of secondary lymphoid organs.
Immunity 2006;25(4):643-54.
2006: Kimberly D Klonowski; Kristina J Williams; Amanda L Marzo; Leo Lefrançois
Cutting edge: IL-7-independent regulation of IL-7 receptor alpha expression and memory CD8 T cell development.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(7):4247-51.
2006: Leo Lefrançois; Amanda L Marzo
The descent of memory T-cell subsets.
Nature reviews. Immunology 2006;6(8):618-23.
2006: Stephen Cose; Clair Brammer; David J Zammit; David A Blair; Leo Lefrançois
CD4 T cells inhibit the CD8 T cell response during low-dose virus infection.
International immunology 2006;18(8):1285-93.
2006: X Tan; Leo Lefrançois
Novel IL-15 isoforms generated by alternative splicing are expressed in the intestinal epithelium.
Genes and immunity 2006;7(5):407-16.
2006: Leo Lefrançois
Development, trafficking, and function of memory T-cell subsets.
Immunological reviews 2006;211():93-103.
2006: Stephen Cose; Clair Brammer; Kamal Khanna; David Masopust; Leo Lefrançois
Evidence that a significant number of naive T cells enter non-lymphoid organs as part of a normal migratory pathway.
European journal of immunology 2006;36(6):1423-33.
2006: David J Zammit; Damian L Turner; Kimberly D Klonowski; Leo Lefrançois; Linda S Cauley
Residual antigen presentation after influenza virus infection affects CD8 T cell activation and migration.
Immunity 2006;24(4):439-49.
2006: David J Zammit; Leo Lefrançois
Dendritic cell-T cell interactions in the generation and maintenance of CD8 T cell memory.
Microbes and infection / Institut Pasteur 2006;8(4):1108-15.
2006: Leo Lefrançois; Lynn Puddington
Intestinal and pulmonary mucosal T cells: local heroes fight to maintain the status quo.
Annual review of immunology 2006;24():681-704.
2005: Amanda L Marzo; Kimberly D Klonowski; Agnes Le Bon; Persephone Borrow; David F Tough; Leo Lefrançois
Initial T cell frequency dictates memory CD8+ T cell lineage commitment.
Nature immunology 2005;6(8):793-9.
2005: Kimberly Schluns; Thomas Stoklasek; Leo Lefrançois
The roles of interleukin-15 receptor alpha: trans-presentation, receptor component, or both?
The international journal of biochemistry & cell biology 2005;37(8):1567-71.
2005: Kimberly D Klonowski; Leo Lefrançois
The CD8 memory T cell subsystem: integration of homeostatic signaling during migration.
Seminars in immunology 2005;17(3):219-29.
2005: David J Zammit; Linda S Cauley; Quynh-Mai Pham; Leo Lefrançois
Dendritic cells maximize the memory CD8 T cell response to infection.
Immunity 2005;22(5):561-70.
2004: Warren N D'Souza; Leo Lefrançois
Frontline: An in-depth evaluation of the production of IL-2 by antigen-specific CD8 T cells in vivo.
European journal of immunology 2004;34(11):2977-85.
2004: Zhanju Liu; Leo Lefrançois
Intestinal epithelial antigen induces mucosal CD8 T cell tolerance, activation, and inflammatory response.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(7):4324-30.
2004: Amanda L Marzo; Vaiva Vezys; Kimberly D Klonowski; Seung-Joo Lee; Guruprasaadh Muralimohan; Meagan Moore; David F Tough; Leo Lefrançois
Fully functional memory CD8 T cells in the absence of CD4 T cells.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(2):969-75.
2004: Kimberly D Klonowski; Kristina J Williams; Amanda L Marzo; David A Blair; Elizabeth G Lingenheld; Leo Lefrançois
Dynamics of blood-borne CD8 memory T cell migration in vivo.
Immunity 2004;20(5):551-62.
2004: David Masopust; Vaiva Vezys; Edward J Usherwood; Linda S Cauley; Sara Olson; Amanda L Marzo; Richard L Ward; David L Woodland; Leo Lefrançois
Activated primary and memory CD8 T cells migrate to nonlymphoid tissues regardless of site of activation or tissue of origin.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(8):4875-82.
2004: Kimberly Schluns; Elizabeth C Nowak; Arturo Cabrera-Hernandez; Lynn Puddington; Leo Lefrançois; Hector L Aguila
Distinct cell types control lymphoid subset development by means of IL-15 and IL-15 receptor alpha expression.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(15):5616-21.
2004: Kimberly Schluns; Kimberly D Klonowski; Leo Lefrançois
Transregulation of memory CD8 T-cell proliferation by IL-15Ralpha+ bone marrow-derived cells.
Blood 2004;103(3):988-94.
2003: Warren N D'Souza; Leo Lefrançois
IL-2 is not required for the initiation of CD8 T cell cycling but sustains expansion.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(11):5727-35.
2003: Leo Lefrançois; Amanda Marzo; Kristina Williams
Sustained response initiation is required for T cell clonal expansion but not for effector or memory development in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(6):2832-9.
2003: Kimberly Schluns; Leo Lefrançois
Cytokine control of memory T-cell development and survival.
Nature reviews. Immunology 2003;3(4):269-79.
2003: David Masopust; Leo Lefrançois
CD8 T-cell memory: the other half of the story.
Microbes and infection / Institut Pasteur 2003;5(3):221-6.
2002: Vaiva Vezys; Leo Lefrançois
Cutting edge: inflammatory signals drive organ-specific autoimmunity to normally cross-tolerizing endogenous antigen.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(12):6677-80.
2002: Leo Lefrançois; David Masopust
T cell immunity in lymphoid and non-lymphoid tissues.
Current opinion in immunology 2002;14(4):503-8.
2002: Warren N D'Souza; Kimberly Schluns; David Masopust; Leo Lefrançois
Essential role for IL-2 in the regulation of antiviral extralymphoid CD8 T cell responses.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(11):5566-72.
2002: Kimberly Schluns; Kristina Williams; Averil Ma; Xin Xiao Zheng; Leo Lefrançois
Cutting edge: requirement for IL-15 in the generation of primary and memory antigen-specific CD8 T cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(10):4827-31.
2002: Leo Lefrançois
Dual personality of memory T cells.
Trends in immunology 2002;23(5):226-8.
2002: Amanda L Marzo; Vaiva Vezys; Kristina Williams; David F Tough; Leo Lefrançois
Tissue-level regulation of Th1 and Th2 primary and memory CD4 T cells in response to Listeria infection.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(9):4504-10.
2002: Leo Lefrançois; Amanda L Marzo; David Masopust; Kimberly Schluns; Vaiva Vezy
Migration of primary and memory CD8 T cells.
Advances in experimental medicine and biology 2002;512():141-6.
2001: David Masopust; Vaiva Vezys; Amanda L Marzo; Leo Lefrançois
Preferential localization of effector memory cells in nonlymphoid tissue.
Science (New York, N.Y.) 2001;291(5512):2413-7.
2001: C Pope; SK Kim; Amanda L Marzo; David Masopust; Kristina Williams; J Jiang; H Shen; Leo Lefrançois
Organ-specific regulation of the CD8 T cell response to Listeria monocytogenes infection.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(5):3402-9.
2001: David Masopust; J Jiang; H Shen; Leo Lefrançois
Direct analysis of the dynamics of the intestinal mucosa CD8 T cell response to systemic virus infection.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(4):2348-56.
2000: Kimberly Schluns; William C Kieper; Stephen C Jameson; Leo Lefrançois
Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo.
Nature immunology 2000;1(5):426-32.
2000: Vaiva Vezys; Sara Olson; Leo Lefrançois
Expression of intestine-specific antigen reveals novel pathways of CD8 T cell tolerance induction.
Immunity 2000;12(5):505-14.
2000: Karen Laky; Leo Lefrançois; Elizabeth G Lingenheld; H Ishikawa; Julia M Lewis; Sara Olson; K Suzuki; Robert E Tigelaar; Lynn Puddington
Enterocyte expression of interleukin 7 induces development of gammadelta T cells and Peyer's patches.
The Journal of experimental medicine 2000;191(9):1569-80.
2000: Leo Lefrançois; John D Altman; Kristina Williams; Sara Olson
Soluble antigen and CD40 triggering are sufficient to induce primary and memory cytotoxic T cells.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(2):725-32.
1999: Leo Lefrançois; Sara Olson; David Masopust
A critical role for CD40-CD40 ligand interactions in amplification of the mucosal CD8 T cell response.
The Journal of experimental medicine 1999;190(9):1275-84.
1999: SK Kim; Kimberly Schluns; Leo Lefrançois
Induction and visualization of mucosal memory CD8 T cells following systemic virus infection.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(8):4125-32.
1999: Leo Lefrançois; Christina M Parker; Sara Olson; W Muller; Werner Muller; Michael P Schön; Lynn Puddington
The role of beta7 integrins in CD8 T cell trafficking during an antiviral immune response.
The Journal of experimental medicine 1999;189(10):1631-8.
1998: SK Kim; DS Reed; Sara Olson; M J Schnell; J K Rose; P A Morton; Leo Lefrançois
Generation of mucosal cytotoxic T cells against soluble protein by tissue-specific environmental and costimulatory signals.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(18):10814-9.
1998: Karen Laky; Leo Lefrançois; U von Freeden-Jeffry; R Murray; Lynn Puddington
The role of IL-7 in thymic and extrathymic development of TCR gamma delta cells.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(2):707-13.
1998: DS Reed; Sara Olson; Leo Lefrançois
Glycosyltransferase regulation mediated by pre-TCR signaling in early thymocyte development.
International immunology 1998;10(4):445-51.
1997: SK Kim; DS Reed; W R Heath; F Carbone; Leo Lefrançois
Activation and migration of CD8 T cells in the intestinal mucosa.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(9):4295-306.
1997: Karen Laky; Leo Lefrançois; Lynn Puddington
Age-dependent intestinal lymphoproliferative disorder due to stem cell factor receptor deficiency: parameters in small and large intestine.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(3):1417-27.
1997: Leo Lefrançois; B Fuller; J W Huleatt; Sara Olson; Lynn Puddington
On the front lines: intraepithelial lymphocytes as primary effectors of intestinal immunity.
Springer seminars in immunopathology 1997;18(4):463-75.
1996: J W Huleatt; Leo Lefrançois
Beta2 integrins and ICAM-1 are involved in establishment of the intestinal mucosal T cell compartment.
Immunity 1996;5(3):263-73.
1996: Leo Lefrançois; Lynn Puddington
The role of the thymus in intestinal intraepithelial T-cell development.
Annals of the New York Academy of Sciences 1996;778():36-46.
1995: B Fuller; Leo Lefrançois
Requirement for extrathymic class I histocompatibility antigens for positive selection of thymus-derived T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(6):2808-11.
1995: J W Huleatt; Leo Lefrançois
Antigen-driven induction of CD11c on intestinal intraepithelial lymphocytes and CD8+ T cells in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(11):5684-93.
1995: Leo Lefrançois; Lynn Puddington
Extrathymic intestinal T-cell development: virtual reality?
Immunology today 1995;16(1):16-21.
1994: Lynn Puddington; Sara Olson; Leo Lefrançois
Interactions between stem cell factor and c-Kit are required for intestinal immune system homeostasis.
Immunity 1994;1(9):733-9.
1994: Leo Lefrançois; Sara Olson
A novel pathway of thymus-directed T lymphocyte maturation.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(3):987-95.
1994: Leo Lefrançois; Terrence Anthony Barrett; W L Havran; Lynn Puddington
Developmental expression of the alpha IEL beta 7 integrin on T cell receptor gamma delta and T cell receptor alpha beta T cells.
European journal of immunology 1994;24(3):635-40.
1986: Lynn Puddington; M J Bevan; J K Rose; Leo Lefrançois
N protein is the predominant antigen recognized by vesicular stomatitis virus-specific cytotoxic T cells.
Journal of virology 1986;60(2):708-17.