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Justin Legleiter

Research Profile

Procedures

Microscopy, Atomic Force

Chemicals & Drugs

Disorders

Living Beings

Physiology

Mutation

Phenomena

Protein Multimerization

Anatomy

Concepts & Ideas

Quaternary Protein Structure

Co-author Network

Publications

TOP 3
Elizabeth A Yates; Elena M Cucco; Michael F Lynch; Sherry L Owens; C Samuel Umbaugh; Justin Legleiter
Specific domains of aβ facilitate aggregation on and association with lipid bilayers.
Gregor P Lotz; Justin Legleiter
The role of amyloidogenic protein oligomerization in neurodegenerative disease.
Kathleen A Burke; Elizabeth A Yates; Justin Legleiter
Amyloid-forming proteins alter the local mechanical properties of lipid membranes.

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All Publications

2013: Elizabeth A Yates; Elena M Cucco; Michael F Lynch; Sherry L Owens; C Samuel Umbaugh; Justin Legleiter
Specific domains of aβ facilitate aggregation on and association with lipid bilayers.
Journal of molecular biology 2013;425(11):1915-33.
2013: Gregor P Lotz; Justin Legleiter
The role of amyloidogenic protein oligomerization in neurodegenerative disease.
Journal of molecular medicine (Berlin, Germany) 2013;91(6):653-64.
2013: Kathleen A Burke; Elizabeth A Yates; Justin Legleiter
Amyloid-forming proteins alter the local mechanical properties of lipid membranes.
Biochemistry 2013;52(5):808-17.
2013: Kathleen A Burke; Elizabeth A Yates; Justin Legleiter
Biophysical insights into how surfaces, including lipid membranes, modulate protein aggregation related to neurodegeneration.
Frontiers in neurology 2013;4():17.
2012: Nicole Shamitko-Klingensmith; Kathleen A Burke; George J Magnone; Kelley M Molchanoff; Justin Legleiter
Mapping the mechanical properties of cholesterol-containing supported lipid bilayers with nanoscale spatial resolution.
Langmuir : the ACS journal of surfaces and colloids 2012;28(37):13411-22.
2012: Leslie G Nucifora; TAMARA RATOVITSKI; Christopher A Ross; Guocheng Yang; Shanshan Zhu; nicolas arbez; Kathleen A Burke; Michael Delannoy; Xia Feng; Steven Finkbeiner; Justin Legleiter; Jason Miller; Paul J Muchowski; Michelle A Poirier
Identification of novel potentially toxic oligomers formed in vitro from mammalian-derived expanded huntingtin exon-1 protein.
The Journal of biological chemistry 2012;287(19):16017-28.
2011: Jason Miller; Emily J Mitchell; Siddhartha Mitra; Paul J Muchowski; Yvonne Newhouse; Alex Osmand; Frédéric Saudou; Mark Segal; Benjamin A Shaby; Leslie M Thompson; Vanitha Thulasiramin; Karl H Weisgraber; Kartika Widjaja; X William Yang; Montserrat Arrasate; Elizabeth Brooks; Kenneth Cheung; Jessica Curtis; Michelle Gray; Danny Hatters; Preethi Krishnan; Justin Legleiter; Clare Peters Libeu; Gregor P Lotz; Eliezer Masliah; Steven Finkbeiner
Identifying polyglutamine protein species in situ that best predict neurodegeneration.
Nature chemical biology 2011;7(12):925-34.
2011: Elizabeth A Yates; Elena M Cucco; Justin Legleiter
Point mutations in aβ induce polymorphic aggregates at liquid/solid interfaces.
ACS chemical neuroscience 2011;2(6):294-307.
2011: Kathleen A Burke; Jordan Godbey; Justin Legleiter
Assessing mutant huntingtin fragment and polyglutamine aggregation by atomic force microscopy.
Methods (San Diego, Calif.) 2011;53(3):275-84.
2011: Phillip M Pifer; Elizabeth A Yates; Justin Legleiter
Point mutations in Aβ result in the formation of distinct polymorphic aggregates in the presence of lipid bilayers.
PloS one 2011;6(1):e16248.
2011: Justin Legleiter
Assessing Aβ aggregation state by atomic force microscopy.
Methods in molecular biology (Clifton, N.J.) 2011;670():57-70.
2010: Gregor P Lotz; Justin Legleiter; Rebecca Aron; Emily J Mitchell; Shao-Yi Huang; Cheping Ng; Charles Glabe; Leslie Michels Thompson; Paul J Muchowski
Hsp70 and Hsp40 functionally interact with soluble mutant huntingtin oligomers in a classic ATP-dependent reaction cycle.
The Journal of biological chemistry 2010;285(49):38183-93.
2010: Justin Legleiter; Emily Mitchell; Gregor P Lotz; Ellen Sapp; Cheping Ng; Marian DiFiglia; Leslie Michels Thompson; Paul J Muchowski
Mutant huntingtin fragments form oligomers in a polyglutamine length-dependent manner in vitro and in vivo.
The Journal of biological chemistry 2010;285(19):14777-90.
2010: Kirupa Sathasivam; Amin Lane; Justin Legleiter; Alice Warley; Ben Woodman; Steve Finkbeiner; Paolo Paganetti; Paul J Muchowski; Stuart Wilson; Gillian P Bates
Identical oligomeric and fibrillar structures captured from the brains of R6/2 and knock-in mouse models of Huntington's disease.
Human molecular genetics 2010;19(1):65-78.
2009: Justin Legleiter; Gregor P Lotz; Jason Miller; Jan Ko; Cheping Ng; Geneva L Williams; Steve Finkbeiner; Paul H Patterson; Paul J Muchowski
Monoclonal antibodies recognize distinct conformational epitopes formed by polyglutamine in a mutant huntingtin fragment.
The Journal of biological chemistry 2009;284(32):21647-58.
2009: Justin Legleiter
The effect of drive frequency and set point amplitude on tapping forces in atomic force microscopy: simulation and experiment.
Nanotechnology 2009;20(24):245703.
2009: Jason S Cheng; Dena B Dubal; Daniel H Kim; Justin Legleiter; Irene H Cheng; Gui-Qiu Yu; Ina C. Tesseur; Tony Wyss-Coray; Paolo Bonaldo; Lennart Mucke
Collagen VI protects neurons against Abeta toxicity.
Nature neuroscience 2009;12(2):119-21.
2007: Irene H Cheng; Kimberly Scearce-Levie; Justin Legleiter; Jorge J Palop; Hilary Gerstein; Nga Bien-Ly; Jukka Puoliväli; Sylvain Lesné; Karen K. Hsiao Ashe; Paul J Muchowski; Lennart Mucke
Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models.
The Journal of biological chemistry 2007;282(33):23818-28.
2006: Dagmar Ehrnhoefer; Martin Duennwald; Phoebe Markovic; Jennifer L Wacker; Sabine Engemann; Margaret Roark; Justin Legleiter; J Lawrence Marsh; Leslie Michels Thompson; Susan Lindquist; Paul J Muchowski; Erich E Wanker
Green tea (-)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models.
Human molecular genetics 2006;15(18):2743-51.
2006: Justin Legleiter; Matthew Park; Brian Cusick; Tomasz Kowalewski
Scanning probe acceleration microscopy (SPAM) in fluids: mapping mechanical properties of surfaces at the nanoscale.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(13):4813-8.
2004: Justin Legleiter; Ronald B DeMattos; David M Holtzman; Tomasz Kowalewski
In situ AFM studies of astrocyte-secreted apolipoprotein E- and J-containing lipoproteins.
Journal of colloid and interface science 2004;278(1):96-106.
2004: Suzanne E Wahrle; Hong Jiang; Maia Parsadanian; Justin Legleiter; Xianlin Han; John D Fryer; Tomasz Kowalewski; David M Holtzman
ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE.
The Journal of biological chemistry 2004;279(39):40987-93.
2004: Justin Legleiter; Dan L Czilli; Bruce Gitter; Ronald B DeMattos; David M Holtzman; Tomasz Kowalewski
Effect of different anti-Abeta antibodies on Abeta fibrillogenesis as assessed by atomic force microscopy.
Journal of molecular biology 2004;335(4):997-1006.
2004: Justin Legleiter; Tomasz Kowalewski
Atomic force microscopy of beta-amyloid: static and dynamic studies of nanostructure and its formation.
Methods in molecular biology (Clifton, N.J.) 2004;242():349-64.
2002: Stephanie Tristram-Nagle; Yufeng Liu; Justin Legleiter; John F Nagle
Structure of gel phase DMPC determined by X-ray diffraction.
Biophysical journal 2002;83(6):3324-35.