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Giuseppe Legname

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Maddalena D Caiati; Giorgia Fattorini; Giuseppe Legname; Victoria F Safiulina; Sudhir Sivakumaran; Enrico Cherubini
PrPC controls via protein kinase A the direction of synaptic plasticity in the immature hippocampus.
Federico Benetti; Stefano Gustincich; Giuseppe Legname
Gene expression profiling and therapeutic interventions in neurodegenerative diseases: a comprehensive study on potentiality and limits.
Giuseppe Legname
Early structural features in mammalian prion conformation conversion.

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All Publications

2013: Maddalena D Caiati; Giorgia Fattorini; Giuseppe Legname; Victoria F Safiulina; Sudhir Sivakumaran; Enrico Cherubini
PrPC controls via protein kinase A the direction of synaptic plasticity in the immature hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013;33(7):2973-83.
2012: Federico Benetti; Stefano Gustincich; Giuseppe Legname
Gene expression profiling and therapeutic interventions in neurodegenerative diseases: a comprehensive study on potentiality and limits.
Expert opinion on drug discovery 2012;7(3):245-59.
2012: Giuseppe Legname
Early structural features in mammalian prion conformation conversion.
Prion 2012;6(1):37-9.
2011: Stefano Benvegnù; Cristina Casalone; Cristiano Corona; Stefano Gustincich; Federica Agostini; Paola Roncaglia; Giuseppe Legname
Developmental influence of the cellular prion protein on the gene expression profile in mouse hippocampus.
Physiological genomics 2011;43(12):711-25.
2011: Stefano Benvegnù; Lisa Gasperini; Giuseppe Legname
Aged PrP null mice show defective processing of neuregulins in the peripheral nervous system.
Molecular and cellular neurosciences 2011;47(1):28-35.
2010: Hoang Ngoc Ai Tran; Fernanda Sousa; Fabio Moda; Subhra Mandal; Munish Chanana; Chiara Vimercati; Michela Morbin; Silke Krol; Fabrizio Tagliavini; Giuseppe Legname
A novel class of potential prion drugs: preliminary in vitro and in vivo data for multilayer coated gold nanoparticles.
Nanoscale 2010;2(12):2724-32.
2010: Stefano Benvegnù; Ilaria Poggiolini; Giuseppe Legname
Neurodevelopmental expression and localization of the cellular prion protein in the central nervous system of the mouse.
The Journal of comparative neurology 2010;518(11):1879-91.
2010: Federico Benetti; Lisa Gasperini; Mattia Zampieri; Giuseppe Legname
Gene expression profiling to identify druggable targets in prion diseases.
Expert opinion on drug discovery 2010;5(2):177-202.
2010: Alessandro Didonna; Giuseppe Legname
Aberrant ERK 1/2 complex activation and localization in scrapie-infected GT1-1 cells.
Molecular neurodegeneration 2010;5():29.
2010: David W Colby; Rachel Wain; Ilia Baskakov; Giuseppe Legname; Christina G Palmer; Hoang-Oanh B Nguyen; Azucena Lemus; Fred E Cohen; Stephen J DeArmond; Stanley B Prusiner
Protease-sensitive synthetic prions.
PLoS pathogens 2010;6(1):e1000736.
2009: David W Colby; Kurt Giles; Giuseppe Legname; Holger Wille; Ilia Baskakov; Stephen J DeArmond; Stanley B Prusiner
Design and construction of diverse mammalian prion strains.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(48):20417-22.
2009: Maurizio Polano; Alpan Bek; Federico Benetti; Marco Lazzarino; Giuseppe Legname
Structural insights into alternate aggregated prion protein forms.
Journal of molecular biology 2009;393(5):1033-42.
2009: Sina Ghaemmaghami; Misol Ahn; Pierre Lessard; Kurt Giles; Giuseppe Legname; Stephen J DeArmond; Stanley B Prusiner
Continuous quinacrine treatment results in the formation of drug-resistant prions.
PLoS pathogens 2009;5(11):e1000673.
2009: Federico Benetti; Giuseppe Legname
De novo mammalian prion synthesis.
Prion 2009;3(4):213-9.
2009: Sung-Hun Bae; Giuseppe Legname; Ana Serban; Stanley B Prusiner; Peter Wright; H Jane Dyson
Prion proteins with pathogenic and protective mutations show similar structure and dynamics.
Biochemistry 2009;48(34):8120-8.
2009: Mattia Zampieri; Giuseppe Legname; Claudio Altafini
Investigating the conformational stability of prion strains through a kinetic replication model.
PLoS computational biology 2009;5(7):e1000420.
2009: Stefano Benvegnù; Diego Franciotta; Josh Sussman; Angela Bachi; Elisabetta Zardini; Paola Torreri; Cedric Govaerts; Salvatore Pizzo; Giuseppe Legname
Prion protein paralog doppel protein interacts with alpha-2-macroglobulin: a plausible mechanism for doppel-mediated neurodegeneration.
PloS one 2009;4(6):e5968.
2007: David W Colby; Qiang Zhang; Shuyi Wang; Darlene Groth; Giuseppe Legname; Detlev Riesner; Stanley B Prusiner
Prion detection by an amyloid seeding assay.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(52):20914-9.
2007: David J King; Jiri G Safar; Giuseppe Legname; Stanley B Prusiner
Thioaptamer interactions with prion proteins: sequence-specific and non-specific binding sites.
Journal of molecular biology 2007;369(4):1001-14.
2007: Barnaby C H May; Julie A Zorn; Juanita Witkop; John Sherrill; Andrew C Wallace; Giuseppe Legname; Stanley B Prusiner; Fred Cohen
Structure-activity relationship study of prion inhibition by 2-aminopyridine-3,5-dicarbonitrile-based compounds: parallel synthesis, bioactivity, and in vitro pharmacokinetics.
Journal of medicinal chemistry 2007;50(1):65-73.
2006: Giuseppe Legname; Hoang-Oanh B Nguyen; David Peretz; Fred Cohen; Stephen J DeArmond; Stanley B Prusiner
Continuum of prion protein structures enciphers a multitude of prion isolate-specified phenotypes.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(50):19105-10.
2006: Jiri G Safar; Holger Wille; Michael D Geschwind; Camille Deering; Diane Latawiec; Ana Serban; David J King; Giuseppe Legname; Karl H Weisgraber; Robert W Mahley; Bruce L Miller; Stephen J DeArmond; Stanley B Prusiner
Human prions and plasma lipoproteins.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(30):11312-7.
2006: Yong Huang; Hideaki Okochi; Barnaby C H May; Giuseppe Legname; Stanley B Prusiner; Leslie Z Benet; B Joseph Guglielmo; Emil T Lin
Quinacrine is mainly metabolized to mono-desethyl quinacrine by CYP3A4/5 and its brain accumulation is limited by P-glycoprotein.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(7):1136-44.
2005: Jamil Kanaani; Stanley B Prusiner; Julia Diacovo; Steinunn Baekkeskov; Giuseppe Legname
Recombinant prion protein induces rapid polarization and development of synapses in embryonic rat hippocampal neurons in vitro.
Journal of neurochemistry 2005;95(5):1373-86.
2005: Giuseppe Legname; Hoang-Oanh B Nguyen; Ilia Baskakov; Fred Cohen; Stephen J DeArmond; Stanley B Prusiner
Strain-specified characteristics of mouse synthetic prions.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(6):2168-73.
2004: Jesús R Requena; Mariana N Dimitrova; Giuseppe Legname; Susana Teijeira; Stanley B Prusiner; Rodney L Levine
Oxidation of methionine residues in the prion protein by hydrogen peroxide.
Archives of biochemistry and biophysics 2004;432(2):188-95.
2004: Lotus Yung; Yong Huang; Pierre Lessard; Giuseppe Legname; Emil T Lin; Michael Baldwin; Stanley B Prusiner; Chongsuk Ryou; B Joseph Guglielmo
Pharmacokinetics of quinacrine in the treatment of prion disease.
BMC infectious diseases 2004;4():53.
2004: Ana Serban; Giuseppe Legname; Kirk Hansen; Nadia Kovaleva; Stanley B Prusiner
Immunoglobulins in urine of hamsters with scrapie.
The Journal of biological chemistry 2004;279(47):48817-20.
2004: Giuseppe Legname; Ilia Baskakov; Hoang-Oanh B Nguyen; Detlev Riesner; Fred Cohen; Stephen J DeArmond; Stanley B Prusiner
Synthetic mammalian prions.
Science (New York, N.Y.) 2004;305(5684):673-6.
2004: Ilia Baskakov; Giuseppe Legname; Zygmunt Gryczynski; Stanley B Prusiner
The peculiar nature of unfolding of the human prion protein.
Protein science : a publication of the Protein Society 2004;13(3):586-95.
2003: Alexander Mironov; Diane Latawiec; Holger Wille; Essia Bouzamondo-Bernstein; Giuseppe Legname; R Anthony Williamson; Dennis Burton; Stephen J DeArmond; Stanley B Prusiner; Peter J Peters
Cytosolic prion protein in neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(18):7183-93.
2003: Colin S Burns; Eliah Aronoff-Spencer; Giuseppe Legname; Stanley B Prusiner; William E Antholine; Gary J Gerfen; Jack Peisach; Glenn L Millhauser
Copper coordination in the full-length, recombinant prion protein.
Biochemistry 2003;42(22):6794-803.
2003: Chongsuk Ryou; Giuseppe Legname; David Peretz; John C Craig; Michael A Baldwin; Stanley B Prusiner
Differential inhibition of prion propagation by enantiomers of quinacrine.
Laboratory investigation; a journal of technical methods and pathology 2003;83(6):837-43.
2003: Chongsuk Ryou; Stanley B Prusiner; Giuseppe Legname
Cooperative binding of dominant-negative prion protein to kringle domains.
Journal of molecular biology 2003;329(2):323-33.
2003: Estelle Leclerc; David Peretz; Haydn Ball; Laura Solforosi; Giuseppe Legname; Jiri G Safar; Ana Serban; Stanley B Prusiner; Dennis R Burton; R Anthony Williamson
Conformation of PrP(C) on the cell surface as probed by antibodies.
Journal of molecular biology 2003;326(2):475-83.
2003: Rose Zamoyska; Albert Basson; Andrew Filby; Giuseppe Legname; Matthew Lovatt; Benedict Seddon
The influence of the src-family kinases, Lck and Fyn, on T cell differentiation, survival and activation.
Immunological reviews 2003;191():107-18.
2002: Giuseppe Legname; Peter Nelken; Zhengyu Guan; Zoltan F Kanyo; Stephen J DeArmond; Stanley B Prusiner
Prion and doppel proteins bind to granule cells of the cerebellum.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(25):16285-90.
2002: Jiri G Safar; Michael Scott; Jeff Monaghan; Camille Deering; Svetlana Didorenko; Julie Vergara; Haydn Ball; Giuseppe Legname; Estelle Leclerc; Laura Solforosi; Hana Serban; Darlene Groth; Dennis R Burton; Stanley B Prusiner; R Anthony Williamson
Measuring prions causing bovine spongiform encephalopathy or chronic wasting disease by immunoassays and transgenic mice.
Nature biotechnology 2002;20(11):1147-50.
2002: Kazuo Kuwata; Hua Li; Hiroaki Yamada; Giuseppe Legname; Stanley B Prusiner; Kazuyuki Akasaka; Tom L James
Locally disordered conformer of the hamster prion protein: a crucial intermediate to PrPSc?
Biochemistry 2002;41(41):12277-83.
2002: Ilia Baskakov; Giuseppe Legname; Michael A Baldwin; Stanley B Prusiner; Fred Cohen
Pathway complexity of prion protein assembly into amyloid.
The Journal of biological chemistry 2002;277(24):21140-8.
2002: David Peretz; R Anthony Williamson; Giuseppe Legname; Yoichi Matsunaga; Julie Vergara; Dennis R Burton; Stephen J DeArmond; Stanley B Prusiner; Michael R Scott
A change in the conformation of prions accompanies the emergence of a new prion strain.
Neuron 2002;34(6):921-32.
2002: Patrick Bosque; Chongsuk Ryou; Glenn C Telling; David Peretz; Giuseppe Legname; Stephen J DeArmond; Stanley B Prusiner
Prions in skeletal muscle.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(6):3812-7.
2001: Richard C Moore; Peter Mastrangelo; Essia Bouzamondo; Cornelia Heinrich; Giuseppe Legname; Stanley B Prusiner; L Hood; David Westaway; Stephen J DeArmond; Patrick Tremblay
Doppel-induced cerebellar degeneration in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(26):15288-93.
2001: Gerold Schmitt-Ulms; Giuseppe Legname; Michael A Baldwin; Haydn L Ball; N Bradon; Patrick Bosque; Kathryn L Crossin; Gerald M Edelman; Stephen J DeArmond; Fred Cohen; Stanley B Prusiner
Binding of neural cell adhesion molecules (N-CAMs) to the cellular prion protein.
Journal of molecular biology 2001;314(5):1209-25.
2001: David Peretz; R Anthony Williamson; Kiyotoshi Kaneko; Julie Vergara; Estelle Leclerc; Gerold Schmitt-Ulms; IR Mehlhorn; Giuseppe Legname; M R Wormald; P M Rudd; R A Dwek; Dennis R Burton; Stanley B Prusiner
Antibodies inhibit prion propagation and clear cell cultures of prion infectivity.
Nature 2001;412(6848):739-43.
2001: Jesús R Requena; Darlene Groth; Giuseppe Legname; Earl R Stadtman; Stanley B Prusiner; Rodney L Levine
Copper-catalyzed oxidation of the recombinant SHa(29-231) prion protein.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(13):7170-5.
2001: Ilia Baskakov; Giuseppe Legname; Stanley B Prusiner; Fred Cohen
Folding of prion protein to its native alpha-helical conformation is under kinetic control.
The Journal of biological chemistry 2001;276(23):19687-90.
2001: Estelle Leclerc; David Peretz; Haydn Ball; H Sakurai; Giuseppe Legname; Ana Serban; Stanley B Prusiner; Dennis R Burton; R Anthony Williamson
Immobilized prion protein undergoes spontaneous rearrangement to a conformation having features in common with the infectious form.
The EMBO journal 2001;20(7):1547-54.
2001: Surachai Supattapone; T Muramoto; Giuseppe Legname; IR Mehlhorn; Fred Cohen; Stephen J DeArmond; Stanley B Prusiner; Michael R Scott
Identification of two prion protein regions that modify scrapie incubation time.
Journal of virology 2001;75(3):1408-13.
2000: Benedict Seddon; Giuseppe Legname; Peter Tomlinson; Rose Zamoyska
Long-term survival but impaired homeostatic proliferation of Naïve T cells in the absence of p56lck.
Science (New York, N.Y.) 2000;290(5489):127-31.
2000: M Albert Basson; T J Wilson; Giuseppe Legname; N Sarner; Peter Tomlinson; Victor L J Tybulewicz; Rose Zamoyska
Early growth response (Egr)-1 gene induction in the thymus in response to TCR ligation during early steps in positive selection is not required for CD8 lineage commitment.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(5):2444-50.
2000: Giuseppe Legname; Benedict Seddon; Matthew Lovatt; Peter Tomlinson; N Sarner; Mauro Tolaini; Keith Williams; Trisha Norton; Dimitris Kioussis; Rose Zamoyska
Inducible expression of a p56Lck transgene reveals a central role for Lck in the differentiation of CD4 SP thymocytes.
Immunity 2000;12(5):537-46.