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Christian Leguern

Research Profile

Living Beings

Chemicals & Drugs

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Genes, MHC Class II

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Publications

TOP 3
Christian Leguern
Tolerogenic property of MHC class I and class II molecules: lessons from a gene therapy approach.
Christian Leguern
Potential role of major histocompatibility complex class II peptides in regulatory tolerance to vascularized grafts.
Ulrike B Matter-Reissmann; Kai-Christian Sonntag; Urs O Gilli; Christian Leguern; Mårten Schneider; Jörg D Seebach
Human Fas-ligand expression on porcine endothelial cells does not protect against xenogeneic natural killer cytotoxicity.

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All Publications

2007: Christian Leguern
Tolerogenic property of MHC class I and class II molecules: lessons from a gene therapy approach.
Frontiers in bioscience : a journal and virtual library 2007;12():3133-9.
2004: Christian Leguern
Potential role of major histocompatibility complex class II peptides in regulatory tolerance to vascularized grafts.
Transplantation 2004;77(1 Suppl):S35-7.
2004: Ulrike B Matter-Reissmann; Kai-Christian Sonntag; Urs O Gilli; Christian Leguern; Mårten Schneider; Jörg D Seebach
Human Fas-ligand expression on porcine endothelial cells does not protect against xenogeneic natural killer cytotoxicity.
Xenotransplantation 2004;11(1):43-52.
2004: Stuart L Houser; Isabel M McMorrow; Christian Leguern; Margaret L Schwarze; Yasushi Fuchimoto; David H Sachs; Joren C Madsen
Histomorphometric comparison of cardiac allograft vasculopathy in miniature swine.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2004;23(1):50-60.
2003: Christian Leguern
Regulation of T-cell functions by MHC class II self-presentation.
Trends in immunology 2003;24(12):633-8.
2003: Brian Lima; Zachary L Gleit; ANDREW CAMERON; Sharon Germana; Michael C Murphy; Robert Consorti; Qing Chang; Julian D Down; Christian Leguern; David H Sachs; Christene A Huang
Engraftment of quiescent progenitors and conversion to full chimerism after nonmyelosuppressive conditioning and hematopoietic cell transplantation in miniature swine.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2003;9(9):571-82.
2003: Goran Andersson; Ben M-W Illigens; Kevin Johnson; David Calderhead; Christian Leguern; Gilles Benichou; Mary E White-Scharf; Julian D Down
Nonmyeloablative conditioning is sufficient to allow engraftment of EGFP-expressing bone marrow and subsequent acceptance of EGFP-transgenic skin grafts in mice.
Blood 2003;101(11):4305-12.
2003: Hideaki Shimada; Sharon Germana; Hideki Hayashi; David H Sachs; Christian Leguern
Expression of MHC class II DQ alpha/beta heterodimers from recombinant polycistronic retroviral genomes.
Surgery today 2003;33(3):183-9.
2002: Gary W Haller; Brian Lima; Shaun Kunisaki; Sharon Germana; Christian Leguern; Christene A Huang; David H Sachs
MHC alloantigens elicit secondary, but not primary, indirect in vitro proliferative responses.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(7):3613-21.
2002: Satoshi Gojo; Shin Yamamoto; Clive Patience; Christian Leguern; David K C Cooper
Gene therapy--its potential in surgery.
Annals of the Royal College of Surgeons of England 2002;84(5):297-301.
2002: Maria Denaro; Donna Kolber-Simonds; Victoria Schad; Shanthini Muthukumar; Sharon Germana; Mary E White-Scharf; Papia T Banerjee; Christian Leguern; Göran Andersson
Expression of xenogeneic MHC class II molecules in HLA-DR(+) and -DR(-) cells: influence of retrovirus vector design and cellular context.
Xenotransplantation 2002;9(2):115-24.
2002: Isabel M McMorrow; Leo Buhler; Sarah Treter; Francisca A Neethling; Ian P J Alwayn; Christopher A Comrack; Hiroshi Kitamura; Michel Awwad; Harout DerSimonian; David K C Cooper; David H Sachs; Christian Leguern
Modulation of the in vivo primate anti-Gal response through administration of anti-idiotypic antibodies.
Xenotransplantation 2002;9(2):106-14.
2002: Isabel M McMorrow; Kavitha Narayan; David H Sachs; Christian Leguern
New intra-renal graft genes associated with tolerance or rejection.
Kidney international 2002;61(1 Suppl):S85-93.
2001: Christophe Baron; Isabel M McMorrow; David H Sachs; Christian Leguern
Persistence of dominant T cell clones in accepted solid organ transplants.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(8):4154-60.
2001: Christophe Baron; David H Sachs; Christian Leguern
A particular TCR beta variable region used by T cells infiltrating kidney transplants.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(4):2589-96.
2001: Jörg D Seebach; Mårten Schneider; Christopher A Comrack; A LeGuern; S A Kolb; P A Knolle; Sharon Germana; Harout DerSimonian; Christian Leguern; David H Sachs
Immortalized bone-marrow derived pig endothelial cells.
Xenotransplantation 2001;8(1):48-61.
2001: Kai-Christian Sonntag; DW Emery; A Yasumoto; Gary W Haller; Sharon Germana; T Sablinski; Akira Shimizu; Kazuhiko Yamada; H Shimada; Scott Arn; David H Sachs; Christian Leguern
Tolerance to solid organ transplants through transfer of MHC class II genes.
The Journal of clinical investigation 2001;107(1):65-71.
2000: Kai-Christian Sonntag; N Nebhard; Gary W Haller; A Yasumoto; David H Sachs; Christian Leguern
Assessment of transduction rates of porcine bone marrow.
Journal of hematotherapy & stem cell research 2000;9(5):721-6.
2000: Kai-Christian Sonntag; Gary W Haller; D Giauffret; Sharon Germana; Steven A Reeves; J Levy; David H Sachs; Christian Leguern
Regulated expression of an MHC class II gene from a promoter-inducible retrovirus.
Human gene therapy 2000;11(14):1961-9.
2000: Leo H Bühler; Sarah Treter; Isabel M McMorrow; Francisca A Neethling; Ian P J Alwayn; Michel Awwad; Aron D Thall; David K C Cooper; Christian Leguern; David H Sachs
Injection of porcine anti-idiotypic antibodies to primate anti-Gal antibodies leads to active inhibition of serum cytotoxicity in a baboon.
Transplantation proceedings 2000;32(5):1102.
2000: henri salmon; I Johnson; Sharon Germana; Gary W Haller; David H Sachs; Christian Leguern
Dendritic cells enriched from swine thymus co-express CD1, CD2 and major histocompatibility complex class II and actively stimulate alloreactive T lymphocytes.
Scandinavian journal of immunology 2000;52(2):164-72.
2000: Satoshi Gojo; David K C Cooper; John Iacomini; Christian Leguern
Gene therapy and transplantation.
Transplantation 2000;69(10):1995-9.
2000: Satoshi Gojo; Akira Shimizu; Francesco L Ierino; Papia T Banerjee; David K C Cooper; Christian Leguern; David H Sachs
Xenogeneic and allogeneic skin grafting after retrovirus-mediated SLA class II DR gene transfer in baboons.
Transplantation proceedings 2000;32(2):289-90.
1999: H Shimada; Sharon Germana; Kai-Christian Sonntag; P Banerjee; Daniel Moore; David H Sachs; Christian Leguern
MHC class II alpha/beta heterodimeric cell surface molecules expressed from a single proviral genome.
Human gene therapy 1999;10(14):2397-405.
1999: Jörg D Seebach; L Pazmany; G L Waneck; F Minja; Sharon Germana; Christian Leguern; David H Sachs
HLA-G expression on porcine endothelial cells protects partially against direct human NK cytotoxicity but not against ADCC.
Transplantation proceedings 1999;31(4):1864-5.
1999: Francesco L Ierino; Satoshi Gojo; Papia T Banerjee; Maria A Giovino; Y Xu; J Gere; C Kaynor; Michel Awwad; R Monroy; J Rembert; T Hatch; A Foley; Tomasz Kozlowski; Kazuhiko Yamada; Francisca A Neethling; Jay Fishman; M Bailin; Thomas R Spitzer; David K C Cooper; A Benedict Cosimi; Christian Leguern; David H Sachs
Transfer of swine major histocompatibility complex class II genes into autologous bone marrow cells of baboons for the induction of tolerance across xenogeneic barriers.
Transplantation 1999;67(8):1119-28.
1999: H Shimada; Robert Alexander; Sharon Germana; David H Sachs; Christian Leguern
Recombinant retrovirus vectors for the expression of MHC class II heterodimers.
Surgery today 1999;29(6):533-41.
1998: DW Emery; H Shimada; Sharon Germana; David H Sachs; Christian Leguern
Transfer of porcine MHC DRalpha into IEalpha-deficient murine bone marrow results in reduced IE-restricted Vbeta usage.
Transplantation 1998;66(8):1081-8.
1997: DW Emery; T Sablinski; H Shimada; Sharon Germana; Pierre R Gianello; A Foley; S Shulman; Scott Arn; Jay Fishman; T Lorf; Volker Nickeleit; Robert B Colvin; David H Sachs; Christian Leguern
Expression of an allogeneic MHC DRB transgene, through retroviral transduction of bone marrow, induces specific reduction of alloreactivity.
Transplantation 1997;64(10):1414-23.
1997: Jörg D Seebach; Christopher A Comrack; Sharon Germana; Christian Leguern; David H Sachs; Harout DerSimonian
HLA-Cw3 expression on porcine endothelial cells protects against xenogeneic cytotoxicity mediated by a subset of human NK cells.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(7):3655-61.
1997: R S Mayfield; H Hayashi; T Sawada; K Bergen; Christian Leguern; Megan Sykes; David H Sachs; John Iacomini
The mechanism of specific prolongation of class I-mismatched skin grafts induced by retroviral gene therapy.
European journal of immunology 1997;27(5):1177-81.
1997: I Giangrande; Kazuhiko Yamada; Scott Arn; T Lorf; David H Sachs; Christian Leguern
Selective increase in CD4-positive graft-infiltrating mononuclear cells among the infiltrates in class I disparate kidney grafts undergoing rejection.
Transplantation 1997;63(5):722-8.
1997: I Giangrande; Kazuhiko Yamada; Sharon Germana; David Sachs; Christian Leguern
Tolerant cells infiltrating class I mismatched swine kidney allografts lack the CD4 single positive subset and down regulate TCR gene expression.
Transplantation proceedings 1997;29(1-2):1164.
1997: H Hayashi; R S Mayfield; T Sawada; Sharon Germana; Megan Sykes; John Iacomini; David H Sachs; Christian Leguern
Role of the thymus in donor specific hyporesponsiveness induced by retroviral transduction of bone marrow using an MHC class I gene.
Transplantation proceedings 1997;29(1-2):1133.
1997: A Yasumoto; Kazuhiko Yamada; T Sablinski; Christian Leguern; Megan Sykes; David H Sachs
Mechanism of tolerance following class II gene transduction of autologous swine bone marrow.
Transplantation proceedings 1997;29(1-2):1132.
1997: Sharon Germana; H Shimada; David H Sachs; Christian Leguern
Retroviral vectors transfer functional MHC class II heterodimers into bone marrow: a genetic approach to tolerance induction.
Transplantation proceedings 1997;29(1-2):1129.
1997: G Blancho; Pierre R Gianello; T Lorf; Sharon Germana; I Giangrande; G Mourad; Robert B Colvin; David H Sachs; Christian Leguern
Molecular and cellular events implicated in local tolerance to kidney allografts in miniature swine.
Transplantation 1997;63(1):26-33.
1996: H Hayashi; Christian Leguern; D H Sachs; Megan Sykes
Alloresistance to K locus class I-mismatched bone marrow engraftment is mediated entirely by CD4+ and CD8+ T cells.
Bone marrow transplantation 1996;18(2):285-92.
1996: DW Emery; D H Sachs; Christian Leguern
Culture and characterization of hematopoietic progenitor cells from miniature swine.
Experimental hematology 1996;24(8):927-35.
1996: H Shimada; DW Emery; G Shafer; Sharon Germana; D H Sachs; Christian Leguern
Miniature swine MHC class II heterodimers expressed through double-copy retroviral vectors.
Transplantation proceedings 1996;28(3):1986-9.
1996: C G Paguio; Sharon Germana; Christian Leguern; P Jubinsky; D H Sachs; DW Emery
Derivation of immortalized swine stromal cell lines.
Transplantation proceedings 1996;28(2):791.
1996: Papia T Banerjee; Francesco L Ierino; G C Kaynor; Maria A Giovino; T Sablinski; DW Emery; M D Rosa; Christian Leguern; D H Sachs; R Monroy
Retrovirus-mediated transfer and expression of swine MHC class II genes in CD34+ monkey stem cells.
Transplantation proceedings 1996;28(2):747-8.
1996: H Hayashi; Christian Leguern; D H Sachs; Megan Sykes
Long-term engraftment of precultured post-5-fluorouracil allogeneic marrow in mice conditioned with a nonmyeloablative regimen: relevance for a gene therapy approach to tolerance induction.
Transplant immunology 1996;4(1):86-90.
1995: Christian Leguern; H Shimada; DW Emery; Sharon Germana; G E Shafer; D H Sachs
Retrovirus-mediated transfer of MHC class II cDNA into swine bone marrow cells.
Journal of molecular medicine (Berlin, Germany) 1995;73(6):269-78.
1995: G Blancho; P Gianello; Sharon Germana; M Baetscher; D H Sachs; Christian Leguern
Molecular identification of porcine interleukin 10: regulation of expression in a kidney allograft model.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(7):2800-4.
1995: C C Fraser; Megan Sykes; R S Lee; D H Sachs; Christian Leguern
Specific unresponsiveness to a retrovirally-transferred class I antigen is controlled through the helper pathway.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(4):1587-95.
1995: I Giangrande; P Gianello; T Lorf; D Vitiello; Christian Leguern; D H Sachs
Humoral response of miniature swine tolerant to class I mismatched renal allografts.
Transplantation proceedings 1995;27(1):559-60.
1995: H Shimada; Sharon Germana; P Banerjee; H Hayashi; D H Sachs; Christian Leguern
A single retroviral vector for transfer of multiple major histocompatibility complex genes: a genetic tool for transplantation tolerance.
Transplantation proceedings 1995;27(1):180-1.
1995: H Hayashi; R S Lee; Sharon Germana; C Fraser; Megan Sykes; D H Sachs; Christian Leguern
Retroviral vectors for long-term expression of allogeneic major histocompatibility complex transduced into syngeneic bone marrow cells.
Transplantation proceedings 1995;27(1):178-9.
1994: DW Emery; Megan Sykes; D H Sachs; Christian Leguern
Mixed swine/human long-term bone marrow cultures.
Transplantation proceedings 1994;26(3):1313-4.
1994: DW Emery; T Sablinski; J Scott Arn; Christian Leguern; D H Sachs
Bone marrow culture and transduction of stem cells in a miniature swine model.
Blood cells 1994;20(2-3):498-502; discussion 502-3.
1993: K Gustafsson; Sharon Germana; T M Sundt; D H Sachs; Christian Leguern
Extensive allelic polymorphism in the CDR2-like region of the miniature swine CD4 molecule.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(3):1365-70.
1993: DW Emery; G E Shafer; E M Karson; D H Sachs; Christian Leguern
Retrovirus-mediated transfer and expression of an allogeneic major histocompatibility complex class II DRB cDNA in swine bone marrow cultures.
Blood 1993;81(9):2460-5.
1993: D H Sachs; C V Smith; DW Emery; Christian Leguern; D Bodine; A Nienhuis; Megan Sykes
Induction of specific tolerance to MHC-disparate allografts through genetic engineering.
Experimental nephrology 1993;1(2):128-33.
1993: DW Emery; C V Smith; G E Shafer; E M Karson; D H Sachs; Christian Leguern
Expression of allogeneic class II cDNA in swine peripheral blood mononuclear cells following retroviral-mediated gene transfer into bone marrow.
Transplantation proceedings 1993;25(1 Pt 1):140-1.
1992: F Hirsch; Sharon Germana; K Gustafsson; K Pratt; D H Sachs; Christian Leguern
Structure and expression of class II alpha genes in miniature swine.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(3):841-6.
1992: T M Sundt; Christian Leguern; Sharon Germana; C V Smith; K Nakajima; J K Lunney; D H Sachs
Characterization of a polymorphism of CD4 in miniature swine.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(10):3195-201.
1992: DW Emery; G E Shafer; E M Karson; D H Sachs; Christian Leguern
Expression of allogeneic class II cDNA in swine bone marrow cells transduced with a recombinant retrovirus.
Transplantation proceedings 1992;24(2):468-9.
1991: G E Shafer; DW Emery; K Gustafsson; Sharon Germana; W F Anderson; D H Sachs; Christian Leguern
Expression of a swine class II gene in murine bone marrow hematopoietic cells by retroviral-mediated gene transfer.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(21):9760-4.
1991: Christian Leguern; G E Shafer; Robert Alexander; Sharon Germana; K Gustafsson; Mona El-Gamil; D H Sachs
Expression of swine class II genes using recombinant retroviral vectors.
Transplantation proceedings 1991;23(1 Pt 1):427-8.
1990: K Gustafsson; Sharon Germana; F Hirsch; K Pratt; Christian Leguern; D H Sachs
Structure of miniature swine class II DRB genes: conservation of hypervariable amino acid residues between distantly related mammalian species.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(24):9798-802.
1990: K Gustafsson; Christian Leguern; F Hirsch; Sharon Germana; K Pratt; D H Sachs
Class II genes of miniature swine. IV. Characterization and expression of two allelic class II DQB cDNA clones.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(6):1946-51.
1990: F Hirsch; D H Sachs; K Gustafsson; K Pratt; Sharon Germana; Christian Leguern
Class II genes of miniature swine. III. Characterization of an expressed pig class II gene homologous to HLA-DQA.
Immunogenetics 1990;31(1):52-6.
1990: K Pratt; D H Sachs; Sharon Germana; Mona El-Gamil; F Hirsch; K Gustafsson; Christian Leguern
Class II genes of miniature swine. II. Molecular identification and characterization of B (beta) genes from the SLAc haplotype.
Immunogenetics 1990;31(1):1-6.