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William Lehman

Research Profile

Chemicals & Drugs

Anatomy

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Microscopy, Electron

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Image Processing, Computer-Assisted

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Publications

TOP 3
Worawit Suphamungmee; Fumihiko Nakamura; John H Hartwig; William Lehman
Electron microscopy and 3D reconstruction reveals filamin Ig domain binding to F-actin.
William Lehman; Kathleen G Morgan
Structure and dynamics of the actin-based smooth muscle contractile and cytoskeletal apparatus.
Xiaochuan Edward Li; Steven B Marston; Worawit Suphamungmee; Stefan Fischer; Michael A Geeves; Miro Janco; William Lehman
The flexibility of two tropomyosin mutants, D175N and E180G, that cause hypertrophic cardiomyopathy.

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All Publications

2012: Worawit Suphamungmee; Fumihiko Nakamura; John H Hartwig; William Lehman
Electron microscopy and 3D reconstruction reveals filamin Ig domain binding to F-actin.
Journal of molecular biology 2012;424(5):248-56.
2012: William Lehman; Kathleen G Morgan
Structure and dynamics of the actin-based smooth muscle contractile and cytoskeletal apparatus.
Journal of muscle research and cell motility 2012;33(6):461-9.
2012: Xiaochuan Edward Li; Steven B Marston; Worawit Suphamungmee; Stefan Fischer; Michael A Geeves; Miro Janco; William Lehman
The flexibility of two tropomyosin mutants, D175N and E180G, that cause hypertrophic cardiomyopathy.
Biochemical and biophysical research communications 2012;424(3):493-6.
2012: Mikkel Herholdt Jensen; William Lehman; Kathleen G Morgan; James Watt; Thomas E Angelini; Sarah Appel; Mohammed El Mezgueldi; Cynthia Gallant; Julie L Hodgkinson; Jeffrey R Moore
Effects of basic calponin on the flexural mechanics and stability of F-actin.
Cytoskeleton (Hoboken, N.J.) 2012;69(1):49-58.
2011: Anthony Cammarato; Chi F Lee; William Lehman; Xiaochuan Edward Li; Mary C Reedy; Sanford I Bernstein
Structural basis for myopathic defects engendered by alterations in the myosin rod.
Journal of molecular biology 2011;414(4):477-84.
2011: Daniel A East; Thomas A Edwards; William Lehman; Stephen R Martin; Duncan Sousa; Daniel P Mulvihill
Altering the stability of the Cdc8 overlap region modulates the ability of this tropomyosin to bind co-operatively to actin and regulate myosin.
The Biochemical journal 2011;438(2):265-73.
2011: Ji Young Mun; Jeffrey Robbins; John L Woodhead; James Gulick; William Lehman; Roger Craig
Electron microscopy and 3D reconstruction of F-actin decorated with cardiac myosin-binding protein C (cMyBP-C).
Journal of molecular biology 2011;410(2):214-25.
2011: CM Gallant; Sarah Appel; Philip Graceffa; Paul C Leavis; Jim Jung-Ching Lin; Peter W Gunning; Galina Schevzov; Christine Chaponnier; Jon DeGnore; William Lehman; Kathleen G Morgan
Tropomyosin variants describe distinct functional subcellular domains in differentiated vascular smooth muscle cells.
American journal of physiology. Cell physiology 2011;300(6):C1356-65.
2011: Xiaochuan Edward Li; Larry Tobacman; Ji Young Mun; Roger Craig; Stefan Fischer; William Lehman
Tropomyosin position on F-actin revealed by EM reconstruction and computational chemistry.
Biophysical journal 2011;100(4):1005-13.
2010: Arthur T Coulton; Daniel A East; Agnieszka Galinska-Rakoczy; William Lehman; Daniel P Mulvihill
The recruitment of acetylated and unacetylated tropomyosin to distinct actin polymers permits the discrete regulation of specific myosins in fission yeast.
Journal of cell science 2010;123(Pt 19):3235-43.
2010: Duncan Sousa; Anthony Cammarato; Ken Jang; Philip Graceffa; Larry Tobacman; Xiaochuan Edward Li; William Lehman
Electron microscopy and persistence length analysis of semi-rigid smooth muscle tropomyosin strands.
Biophysical journal 2010;99(3):862-8.
2010: Xiaochuan Edward Li; William Lehman; Stefan Fischer
The relationship between curvature, flexibility and persistence length in the tropomyosin coiled-coil.
Journal of structural biology 2010;170(2):313-8.
2010: Xiaochuan Edward Li; William Lehman; Stefan Fischer; Kenneth C Holmes
Curvature variation along the tropomyosin molecule.
Journal of structural biology 2010;170(2):307-12.
2010: Xiaochuan Edward Li; Kenneth C Holmes; William Lehman; Hyunsuk Jung; Stefan Fischer
The shape and flexibility of tropomyosin coiled coils: implications for actin filament assembly and regulation.
Journal of molecular biology 2010;395(2):327-39.
2010: Anthony Cammarato; Roger Craig; William Lehman
Electron microscopy and three-dimensional reconstruction of native thin filaments reveal species-specific differences in regulatory strand densities.
Biochemical and biophysical research communications 2010;391(1):193-7.
2009: William Lehman; Agnieszka Galińska-Rakoczy; Victoria Hatch; Larry Tobacman; Roger Craig
Structural basis for the activation of muscle contraction by troponin and tropomyosin.
Journal of molecular biology 2009;388(4):673-81.
2008: Agnieszka Galińska-Rakoczy; Patti L. Engel; Chen Xu; Hyunsuk Jung; Roger Craig; Larry Tobacman; William Lehman
Structural basis for the regulation of muscle contraction by troponin and tropomyosin.
Journal of molecular biology 2008;379(5):929-35.
2008: Robin Maytum; Victoria Hatch; Manfred Konrad; William Lehman; Michael A Geeves
Ultra short yeast tropomyosins show novel myosin regulation.
The Journal of biological chemistry 2008;283(4):1902-10.
2008: William Lehman; Roger Craig
Tropomyosin and the steric mechanism of muscle regulation.
Advances in experimental medicine and biology 2008;644():95-109.
2008: Kenneth C Holmes; William Lehman
Gestalt-binding of tropomyosin to actin filaments.
Journal of muscle research and cell motility 2008;29(6-8):213-9.
2006: Katrina J V Poole; Michael Lorenz; Gwyndaf Evans; Gerd Rosenbaum; Alnoor Pirani; Roger Craig; Larry Tobacman; William Lehman; Kenneth C Holmes
A comparison of muscle thin filament models obtained from electron microscopy reconstructions and low-angle X-ray fibre diagrams from non-overlap muscle.
Journal of structural biology 2006;155(2):273-84.
2006: Kiran Pant; David Chereau; Victoria Hatch; Roberto Dominguez; William Lehman
Cortactin binding to F-actin revealed by electron microscopy and 3D reconstruction.
Journal of molecular biology 2006;359(4):840-7.
2006: Alnoor Pirani; Maia V Vinogradova; Paul M G Curmi; William A King; Robert J Fletterick; Roger Craig; Larry Tobacman; Chen Xu; Victoria Hatch; William Lehman
An atomic model of the thin filament in the relaxed and Ca2+-activated states.
Journal of molecular biology 2006;357(3):707-17.
2005: Anthony Cammarato; Roger Craig; John C Sparrow; William Lehman
E93K charge reversal on actin perturbs steric regulation of thin filaments.
Journal of molecular biology 2005;347(5):889-94.
2005: Alnoor Pirani; Chen Xu; Victoria Hatch; Roger Craig; Larry Tobacman; William Lehman
Single particle analysis of relaxed and activated muscle thin filaments.
Journal of molecular biology 2005;346(3):761-72.
2005: Huiyu Gong; Victoria Hatch; Laith Ali; William Lehman; Roger Craig; Larry Tobacman
Mini-thin filaments regulated by troponin-tropomyosin.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(3):656-61.
2004: Darren Foster; Renjian Huang; Victoria Hatch; Roger Craig; Philip Graceffa; William Lehman; C-L Albert Wang
Modes of caldesmon binding to actin: sites of caldesmon contact and modulation of interactions by phosphorylation.
The Journal of biological chemistry 2004;279(51):53387-94.
2004: Anthony Cammarato; Victoria Hatch; Judith Saide; Roger Craig; John C Sparrow; Larry Tobacman; William Lehman
Drosophila muscle regulation characterized by electron microscopy and three-dimensional reconstruction of thin filament mutants.
Biophysical journal 2004;86(3):1618-24.
2004: William Lehman; Roger Craig
The structure of the vertebrate striated muscle thin filament: a tribute to the contributions of Jean Hanson.
Journal of muscle research and cell motility 2004;25(6):455-66.
2004: William Lehman; Roger Craig; John Kendrick-Jones; Andrew J Sutherland-Smith
An open or closed case for the conformation of calponin homology domains on F-actin?
Journal of muscle research and cell motility 2004;25(4-5):351-8.
2003: Andrew J Sutherland-Smith; Carolyn A Moores; Fiona L M Norwood; Victoria Hatch; Roger Craig; John Kendrick-Jones; William Lehman
An atomic model for actin binding by the CH domains and spectrin-repeat modules of utrophin and dystrophin.
Journal of molecular biology 2003;329(1):15-33.
2002: Larry Tobacman; Mahta Nihli; Carol Butters; Mark Heller; Victoria Hatch; Roger Craig; William Lehman; Earl Homsher
The troponin tail domain promotes a conformational state of the thin filament that suppresses myosin activity.
The Journal of biological chemistry 2002;277(31):27636-42.
2001: Victoria Hatch; Gang Zhi; L Smith; James T Stull; Roger Craig; William Lehman
Myosin light chain kinase binding to a unique site on F-actin revealed by three-dimensional image reconstruction.
The Journal of cell biology 2001;154(3):611-7.
2001: J Burhop; Michael S Rosol; Roger Craig; Larry Tobacman; William Lehman
Effects of a cardiomyopathy-causing troponin t mutation on thin filament function and structure.
The Journal of biological chemistry 2001;276(23):20788-94.
2001: William Lehman; Michael S Rosol; Larry Tobacman; Roger Craig
Troponin organization on relaxed and activated thin filaments revealed by electron microscopy and three-dimensional reconstruction.
Journal of molecular biology 2001;307(3):739-44.
2000: William Lehman; Victoria Hatch; VL Korman; Michael S Rosol; L Thomas; Robin Maytum; Michael A Geeves; Jennifer E Van Eyk; Larry Tobacman; Roger Craig
Tropomyosin and actin isoforms modulate the localization of tropomyosin strands on actin filaments.
Journal of molecular biology 2000;302(3):593-606.
2000: VL Korman; Victoria Hatch; K Y Dixon; Roger Craig; William Lehman; Larry Tobacman
An actin subdomain 2 mutation that impairs thin filament regulation by troponin and tropomyosin.
The Journal of biological chemistry 2000;275(29):22470-8.
2000: Michael S Rosol; William Lehman; Roger Craig; CA Landis; Carol Butters; Larry Tobacman
Three-dimensional reconstruction of thin filaments containing mutant tropomyosin.
Biophysical journal 2000;78(2):908-17.
1999: Chen Xu; Roger Craig; Larry Tobacman; R Horowitz; William Lehman
Tropomyosin positions in regulated thin filaments revealed by cryoelectron microscopy.
Biophysical journal 1999;77(2):985-92.
1997: William Lehman; P Vibert; Roger Craig
Visualization of caldesmon on smooth muscle thin filaments.
Journal of molecular biology 1997;274(3):310-7.
1997: JL Hodgkinson; Mohammed El Mezgueldi; Roger Craig; P Vibert; Steven B Marston; William Lehman
3-D image reconstruction of reconstituted smooth muscle thin filaments containing calponin: visualization of interactions between F-actin and calponin.
Journal of molecular biology 1997;273(1):150-9.
1997: JL Hodgkinson; Steven B Marston; Roger Craig; P Vibert; William Lehman
Three-dimensional image reconstruction of reconstituted smooth muscle thin filaments: effects of caldesmon.
Biophysical journal 1997;72(6):2398-404.
1997: P Vibert; Roger Craig; William Lehman
Steric-model for activation of muscle thin filaments.
Journal of molecular biology 1997;266(1):8-14.
1995: William Lehman; P Vibert; P Uman; Roger Craig
Steric-blocking by tropomyosin visualized in relaxed vertebrate muscle thin filaments.
Journal of molecular biology 1995;251(2):191-6.
1994: William Lehman; Roger Craig; P Vibert
Ca(2+)-induced tropomyosin movement in Limulus thin filaments revealed by three-dimensional reconstruction.
Nature 1994;368(6466):65-7.
1993: William Lehman; D Denault; Steven B Marston
The caldesmon content of vertebrate smooth muscle.
Biochimica et biophysica acta 1993;1203(1):53-9.
1993: P Vibert; Roger Craig; William Lehman
Three-dimensional reconstruction of caldesmon-containing smooth muscle thin filaments.
The Journal of cell biology 1993;123(2):313-21.
1992: William Lehman; D Denault; Steven B Marston
Novel immunological technique.
Journal of muscle research and cell motility 1992;13(5):582-5.
1990: C Moody; William Lehman; Roger Craig
Caldesmon and the structure of smooth muscle thin filaments: electron microscopy of isolated thin filaments.
Journal of muscle research and cell motility 1990;11(2):176-85.
1990: William Lehman; C Moody; Roger Craig
Caldesmon and the structure of vertebrate smooth muscle thin filaments. A minireview.
Annals of the New York Academy of Sciences 1990;599():75-84.
1989: William Lehman
35 kDa proteins are not components of vertebrate smooth muscle thin filaments.
Biochimica et biophysica acta 1989;996(1-2):57-61.
1989: William Lehman; Roger Craig; J Lui; C Moody
Caldesmon and the structure of smooth muscle thin filaments: immunolocalization of caldesmon on thin filaments.
Journal of muscle research and cell motility 1989;10(2):101-12.
1988: Steven B Marston; Charles Redwood; William Lehman
Reversal of caldesmon function by anti-caldesmon antibodies confirms its role in the calcium regulation of vascular smooth muscle thin filaments.
Biochemical and biophysical research communications 1988;155(1):197-202.
1985: Steven B Marston; William Lehman
Caldesmon is a Ca2+-regulatory component of native smooth-muscle thin filaments.
The Biochemical journal 1985;231(3):517-22.