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Ruth Lehr

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Chemicals & Drugs

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Glenn S Van Aller; Jeff D Carson; Christine Fernandes; Ruth Lehr; Robert H Sinnamon; Robert B Kirkpatrick; Peter J Tummino; Lusong Luo
Characterization of PI3K class IA isoforms with regulatory subunit p55alpha using a scintillation proximity assay.
Jeffrey D Carson; Glenn S Van Aller; Ruth Lehr; Robert H Sinnamon; Robert B Kirkpatrick; Kurt R Auger; Dashyant Dhanak; Robert Copeland; Richard R Gontarek; Peter J Tummino; Lusong Luo
Effects of oncogenic p110alpha subunit mutations on the lipid kinase activity of phosphoinositide 3-kinase.
Lusong Luo; Cynthia A Parrish; Neysa Nevins; Dean E McNulty; Amita M Chaudhari; Jeffrey D Carson; Valery Sudakin; Antony N Shaw; Ruth Lehr; Huizhen Zhao; Sharon Sweitzer; Latesh Lad; Kenneth W Wood; Roman Sakowicz; Roland S Annan; Pearl S Huang; Jeffrey R Jackson; Dashyant Dhanak; Robert Copeland; Kurt R Auger
ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism.

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All Publications

2008: Glenn S Van Aller; Jeff D Carson; Christine Fernandes; Ruth Lehr; Robert H Sinnamon; Robert B Kirkpatrick; Peter J Tummino; Lusong Luo
Characterization of PI3K class IA isoforms with regulatory subunit p55alpha using a scintillation proximity assay.
Analytical biochemistry 2008;383(2):311-5.
2008: Jeffrey D Carson; Glenn S Van Aller; Ruth Lehr; Robert H Sinnamon; Robert B Kirkpatrick; Kurt R Auger; Dashyant Dhanak; Robert Copeland; Richard R Gontarek; Peter J Tummino; Lusong Luo
Effects of oncogenic p110alpha subunit mutations on the lipid kinase activity of phosphoinositide 3-kinase.
The Biochemical journal 2008;409(2):519-24.
2007: Lusong Luo; Cynthia A Parrish; Neysa Nevins; Dean E McNulty; Amita M Chaudhari; Jeffrey D Carson; Valery Sudakin; Antony N Shaw; Ruth Lehr; Huizhen Zhao; Sharon Sweitzer; Latesh Lad; Kenneth W Wood; Roman Sakowicz; Roland S Annan; Pearl S Huang; Jeffrey R Jackson; Dashyant Dhanak; Robert Copeland; Kurt R Auger
ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism.
Nature chemical biology 2007;3(11):722-6.
2003: Michael Doyle; Shin-Shay Tian; Stephen G Miller; Linda Kessler; Audrey E Baker; Michael Brigham-Burke; Susan B Dillon; Kevin J Duffy; Richard M Keenan; Ruth Lehr; Jon Rosen; Lumelle Schneeweis; John Trill; Peter Young; Juan I Luengo; Peter Lamb
Selective binding and oligomerization of the murine granulocyte colony-stimulating factor receptor by a low molecular weight, nonpeptidyl ligand.
The Journal of biological chemistry 2003;278(11):9426-34.
2002: Nicholas J Laping; Eugene T Grygielko; A Mathur; S Butter; J Bomberger; Christopher Tweed; W Martin; James A Fornwald; Ruth Lehr; John D Harling; Laramie M Gaster; James F Callahan; Barbara A Olson
Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542.
Molecular pharmacology 2002;62(1):58-64.
2002: Sanjay Kumar; Charles R Hanning; Michael Brigham-Burke; David J Rieman; Ruth Lehr; Sanjay S Khandekar; Robert B Kirkpatrick; Gilbert F Scott; John Lee; Frank J Lynch; Wentao Gao; Andrea Gambotto; Michael T Lotze
Interleukin-1F7B (IL-1H4/IL-1F7) is processed by caspase-1 and mature IL-1F7B binds to the IL-18 receptor but does not induce IFN-gamma production.
Cytokine 2002;18(2):61-71.
2002: James F Callahan; Joelle L Burgess; James A Fornwald; Laramie M Gaster; John D Harling; Frank P Harrington; Jag Heer; Chet Kwon; Ruth Lehr; A Mathur; Barbara A Olson; Joseph Weinstock; Nicholas J Laping
Identification of novel inhibitors of the transforming growth factor beta1 (TGF-beta1) type 1 receptor (ALK5).
Journal of medicinal chemistry 2002;45(5):999-1001.
2000: Ruth Lehr; Louis C Elefante; K K Kikly; S P O'Brien; Robert B Kirkpatrick
A modified metal-ion affinity chromatography procedure for the purification of histidine-tagged recombinant proteins expressed in Drosophila S2 cells.
Protein expression and purification 2000;19(3):362-8.
2000: Sanjay Kumar; PC McDonnell; Ruth Lehr; Lauren A Tierney; MN Tzimas; Don E Griswold; E A Capper; R Tal-Singer; G I Wells; Michael Doyle; Peter Young
Identification and initial characterization of four novel members of the interleukin-1 family.
The Journal of biological chemistry 2000;275(14):10308-14.