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Hans Lehrach

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Publications

TOP 3
Greber Boris; Lehrach Hans; Adjaye James
Control of early fate decisions in human ES cells by distinct states of TGFbeta pathway activity.
Ralser Markus; Wamelink Mirjam M; Struys Eduard A; Joppich Christian; Krobitsch Sylvia; Jakobs Cornelis; Lehrach Hans
A catabolic block does not sufficiently explain how 2-deoxy-D-glucose inhibits cell growth.
Hufton Andrew L; Groth Detlef; Vingron Martin; Lehrach Hans; Poustka Albert J; Panopoulou Georgia
Early vertebrate whole genome duplications were predated by a period of intense genome rearrangement.

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All Publications

2008: Greber Boris; Lehrach Hans; Adjaye James
Control of early fate decisions in human ES cells by distinct states of TGFbeta pathway activity.
Stem cells and development 2008;17(6):1065-77.
2008: Ralser Markus; Wamelink Mirjam M; Struys Eduard A; Joppich Christian; Krobitsch Sylvia; Jakobs Cornelis; Lehrach Hans
A catabolic block does not sufficiently explain how 2-deoxy-D-glucose inhibits cell growth.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(46):17807-11.
2008: Hufton Andrew L; Groth Detlef; Vingron Martin; Lehrach Hans; Poustka Albert J; Panopoulou Georgia
Early vertebrate whole genome duplications were predated by a period of intense genome rearrangement.
Genome research 2008;18(10):1582-91.
2008: Rosenkranz Ruben; Borodina Tatiana; Lehrach Hans; Himmelbauer Heinz
Characterizing the mouse ES cell transcriptome with Illumina sequencing.
Genomics 2008;92(4):187-94.
2008: Lange Martin; Kaynak Bogac; Forster Ulrike B; Tönjes Martje; Fischer Jenny J; Grimm Christina; Schlesinger Jenny; Just Steffen; Dunkel Ilona; Krueger Tammo; Mebus Siegrun; Lehrach Hans; Lurz Rudi; Gobom Johan; Rottbauer Wolfgang; Abdelilah-Seyfried Salim; Sperling Silke
Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex.
Genes & development 2008;22(17):2370-84.
2008: Sultan Marc; Schulz Marcel H; Richard Hugues; Magen Alon; Klingenhoff Andreas; Scherf Matthias; Seifert Martin; Borodina Tatjana; Soldatov Aleksey; Parkhomchuk Dmitri; Schmidt Dominic; O'Keeffe Sean; Haas Stefan; Vingron Martin; Lehrach Hans; Yaspo Marie-Laure
A global view of gene activity and alternative splicing by deep sequencing of the human transcriptome.
Science (New York, N.Y.) 2008;321(5891):956-60.
2008: Parsons Michael J; Grimm Christina H; Paya-Cano Jose L; Sugden Karen; Nietfeld Wilfried; Lehrach Hans; Schalkwyk Leonard C
Using hippocampal microRNA expression differences between mouse inbred strains to characterise miRNA function.
Mammalian genome : official journal of the International Mammalian Genome Society 2008;19(7-8):552-60.
2008: Regenbrecht Christian Ra; Jung Marc; Lehrach Hans; Adjaye James
The molecular basis of genistein-induced mitotic arrest and exit of self-renewal in embryonal carcinoma and primary cancer cell lines.
BMC medical genomics 2008;1():49.
2008: Ralser Markus; Nebel Almut; Kleindorp Rabea; Krobitsch Sylvia; Lehrach Hans; Schreiber Stefan; Reinhardt Richard; Timmermann Bernd
Sequencing and genotypic analysis of the triosephosphate isomerase (TPI1) locus in a large sample of long-lived Germans.
BMC genetics 2008;9():38.
2008: Fiebitz Andrea; Nyarsik Lajos; Haendler Bernard; Hu Yu-Hui; Wagner Florian; Thamm Sabine; Lehrach Hans; Janitz Michal; Vanhecke Dominique
High-throughput mammalian two-hybrid screening for protein-protein interactions using transfected cell arrays.
BMC genomics 2008;9():68.
2007: Adjaye James; Herwig Ralf; Brink Thore C; Herrmann Doris; Greber Boris; Sudheer Smita; Groth Detlef; Carnwath Joseph W; Lehrach Hans; Niemann Heiner
Conserved molecular portraits of bovine and human blastocysts as a consequence of the transition from maternal to embryonic control of gene expression.
Physiological genomics 2007;31(2):315-27.
2007: Wierling Christoph; Herwig Ralf; Lehrach Hans
Resources, standards and tools for systems biology.
Briefings in functional genomics & proteomics 2007;6(3):240-51.
2007: Ziegler Gina; Harhausen Denise; Schepers Claudia; Hoffmann Olaf; Röhr Christina; Prinz Vincent; König Janett; Lehrach Hans; Nietfeld Wilfried; Trendelenburg George
TLR2 has a detrimental role in mouse transient focal cerebral ischemia.
Biochemical and biophysical research communications 2007;359(3):574-9.
2007: Dahl Andreas; Sultan Marc; Jung Alexander; Schwartz Regine; Lange Matthias; Steinwand Michael; Livak Kenneth J; Lehrach Hans; Nyarsik Lajos
Quantitative PCR based expression analysis on a nanoliter scale using polymer nano-well chips.
Biomedical microdevices 2007;9(3):307-14.
2007: Liu Jian-Ping; Drungowski Mario; Nyársik Lajos; Schwartz Regine; Lehrach Hans; Herwig Ralf; Janitz Michal
Oligonucleotide fingerprinting of arrayed genomic DNA sequences using LNA-modified hybridization probes.
Combinatorial chemistry & high throughput screening 2007;10(4):269-76.
2007: Purmann Antje; Toedling Joern; Schueler Markus; Carninci Piero; Lehrach Hans; Hayashizaki Yoshihide; Huber Wolfgang; Sperling Silke
Genomic organization of transcriptomes in mammals: Coregulation and cofunctionality.
Genomics 2007;89(5):580-7.
2007: Nonhoff Ute; Ralser Markus; Welzel Franziska; Piccini Ilaria; Balzereit Daniela; Yaspo Marie-Laure; Lehrach Hans; Krobitsch Sylvia
Ataxin-2 interacts with the DEAD/H-box RNA helicase DDX6 and interferes with P-bodies and stress granules.
Molecular biology of the cell 2007;18(4):1385-96.
2007: Bennett James T; Joubin Katherine; Cheng Simon; Aanstad Pia; Herwig Ralf; Clark Matthew; Lehrach Hans; Schier Alexander F
Nodal signaling activates differentiation genes during zebrafish gastrulation.
Developmental biology 2007;304(2):525-40.
2007: Gerisch Birgit; Rottiers Veerle; Li Dongling; Motola Daniel L; Cummins Carolyn L; Lehrach Hans; Mangelsdorf David J; Antebi Adam
A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(12):5014-9.
2007: Babaie Yasmin; Herwig Ralf; Greber Boris; Brink Thore C; Wruck Wasco; Groth Detlef; Lehrach Hans; Burdon Tom; Adjaye James
Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells.
Stem cells (Dayton, Ohio) 2007;25(2):500-10.
2007: Greber Boris; Lehrach Hans; Adjaye James
Fibroblast growth factor 2 modulates transforming growth factor beta signaling in mouse embryonic fibroblasts and human ESCs (hESCs) to support hESC self-renewal.
Stem cells (Dayton, Ohio) 2007;25(2):455-64.
2007: Sultan Marc; Piccini Ilaria; Balzereit Daniela; Herwig Ralf; Saran Nidhi G; Lehrach Hans; Reeves Roger H; Yaspo Marie-Laure
Gene expression variation in Down's syndrome mice allows prioritization of candidate genes.
Genome biology 2007;8(5):R91.
2007: Poustka Albert J; Kühn Alexander; Groth Detlef; Weise Vesna; Yaguchi Shunsuke; Burke Robert D; Herwig Ralf; Lehrach Hans; Panopoulou Georgia
A global view of gene expression in lithium and zinc treated sea urchin embryos: new components of gene regulatory networks.
Genome biology 2007;8(5):R85.
2007: Greber Boris; Lehrach Hans; Adjaye James
Silencing of core transcription factors in human EC cells highlights the importance of autocrine FGF signaling for self-renewal.
BMC developmental biology 2007;7():46.
2007: Nordhoff Eckhard; Lehrach Hans
Identification and characterization of DNA-binding proteins by mass spectrometry.
Advances in biochemical engineering/biotechnology 2007;104():111-95.
2006: Müller Hannah; Fogeron Marie-Laure; Lehmann Verena; Lehrach Hans; Lange Bodo M H
A centrosome-independent role for gamma-TuRC proteins in the spindle assembly checkpoint.
Science (New York, N.Y.) 2006;314(5799):654-7.
2006: Liu Jian-Ping; Guerasimova Anna; Schwartz Regine; Lange Matthias; Lehrach Hans; Nyársik Lajos; Janitz Michal
LNA-modified oligodeoxynucleotide hybridization with DNA microarrays printed on nanoporous membrane slides.
Combinatorial chemistry & high throughput screening 2006;9(8):591-7.
2006: Ralser Markus; Querfurth Robert; Warnatz Hans-Jörg; Lehrach Hans; Yaspo Marie-Laure; Krobitsch Sylvia
An efficient and economic enhancer mix for PCR.
Biochemical and biophysical research communications 2006;347(3):747-51.
2006: Makrantonaki Evgenia; Adjaye James; Herwig Ralf; Brink Thore C; Groth Detlef; Hultschig Claus; Lehrach Hans; Zouboulis Christos C
Age-specific hormonal decline is accompanied by transcriptional changes in human sebocytes in vitro.
Aging cell 2006;5(4):331-44.
2006: Gebert Claudia; Wrenzycki Christine; Herrmann Doris; Gröger Daniela; Reinhardt Richard; Hajkova Petra; Lucas-Hahn Andrea; Carnwath Joseph; Lehrach Hans; Niemann Heiner
The bovine IGF2 gene is differentially methylated in oocyte and sperm DNA.
Genomics 2006;88(2):222-9.
2006: Kepper Pamela; Reinhardt Richard; Dahl Andreas; Lehrach Hans; Sauer Sascha
Matrix-assisted laser desorption/ionization mass spectrometric analysis of DNA on microarrays.
Clinical chemistry 2006;52(7):1303-10.
2006: Guerasimova Anna; Nyarsik Lajos; Liu Jian-Ping; Schwartz Regine; Lange Matthias; Lehrach Hans; Janitz Michal
Liquid-based hybridization assay with real-time detection in miniaturized array platforms.
Biomolecular engineering 2006;23(1):35-40.
2006: Hultschig Claus; Kreutzberger Jürgen; Seitz Harald; Konthur Zoltán; Büssow Konrad; Lehrach Hans
Recent advances of protein microarrays.
Current opinion in chemical biology 2006;10(1):4-10.
2006: Kowald Axel; Lehrach Hans; Klipp Edda
Alternative pathways as mechanism for the negative effects associated with overexpression of superoxide dismutase.
Journal of theoretical biology 2006;238(4):828-40.
2006: Horn Sabine; Lueking Angelika; Murphy Derek; Staudt Alexander; Gutjahr Claudia; Schulte Kirsten; König Andrea; Landsberger Martin; Lehrach Hans; Felix Stephan B; Cahill Dolores J
Profiling humoral autoimmune repertoire of dilated cardiomyopathy (DCM) patients and development of a disease-associated protein chip.
Proteomics 2006;6(2):605-13.
2006: Weichart Dieter; Gobom Johan; Klopfleisch Sina; Häsler Robert; Gustavsson Niklas; Billmann Susanne; Lehrach Hans; Seegert Dirk; Schreiber Stefan; Rosenstiel Philip
Analysis of NOD2-mediated proteome response to muramyl dipeptide in HEK293 cells.
The Journal of biological chemistry 2006;281(4):2380-9.
2006: Otterhag Lotta; Gustavsson Niklas; Alsterfjord Magnus; Pical Christophe; Lehrach Hans; Gobom Johan; Sommarin Marianne
Arabidopsis PDK1: identification of sites important for activity and downstream phosphorylation of S6 kinase.
Biochimie 2006;88(1):11-21.
2006: Sauer Sascha; Reinhardt Richard; Lehrach Hans; Gut Ivo G
Single-nucleotide polymorphisms: analysis by mass spectrometry.
Nature protocols 2006;1(4):1761-71.
2006: Ralser Markus; Heeren Gino; Breitenbach Michael; Lehrach Hans; Krobitsch Sylvia
Triose phosphate isomerase deficiency is caused by altered dimerization--not catalytic inactivity--of the mutant enzymes.
PloS one 2006;1():e30.
2006: Herwig Ralf; Lehrach Hans
Expression profiling of drug response--from genes to pathways.
Dialogues in clinical neuroscience 2006;8(3):283-93.
2006: Makrantonaki Evgenia; Adjaye James; Herwig Ralf; Brink Thore C; Groth Detlef; Hultschig Claus; Lehrach Hans; Zouboulis Christos C
Aging of human sebocytes in vitro induced by exposure to a defined hormone environment.
Dermatology (Basel, Switzerland) 2006;213(3):262-3.
2006: Wolski Witold E; Farrow Malcolm; Emde Anne-Katrin; Lehrach Hans; Lalowski Maciej; Reinert Knut
Analytical model of peptide mass cluster centres with applications.
Proteome science 2006;4():18.
2006: Hu Yu-Hui; Warnatz Hans-Jörg; Vanhecke Dominique; Wagner Florian; Fiebitz Andrea; Thamm Sabine; Kahlem Pascal; Lehrach Hans; Yaspo Marie-Laure; Janitz Michal
Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins.
BMC genomics 2006;7():155.
2006: Janitz M; Vanhecke D; Lehrach H
High-throughput RNA interference in functional genomics.
Handbook of experimental pharmacology 2006;(173):97-104.
2005: Sauer Sascha; Konthur Zoltán; Lehrach Hans
Genome projects and the functional-genomic era.
Combinatorial chemistry & high throughput screening 2005;8(8):659-67.
2005: Sperling Silke; Grimm Christina H; Dunkel Ilona; Mebus Siegrun; Sperling Hans-Peter; Ebner Arno; Galli Raffaello; Lehrach Hans; Fusch Christoph; Berger Felix; Hammer Stefanie
Identification and functional analysis of CITED2 mutations in patients with congenital heart defects.
Human mutation 2005;26(6):575-82.
2005: Hu Y-H; Vanhecke D; Lehrach H; Janitz M
High-throughput subcellular protein localization using cell arrays.
Biochemical Society transactions 2005;33(Pt 6):1407-8.
2005: Mirgorodskaya Ekaterina; Wanker Erich; Otto Albrecht; Lehrach Hans; Gobom Johan
Method for qualitative comparisons of protein mixtures based on enzyme-catalyzed stable-isotope incorporation.
Journal of proteome research 2005;4(6):2109-16.
2005: Adjaye James; Huntriss John; Herwig Ralf; BenKahla Alia; Brink Thore C; Wierling Christoph; Hultschig Claus; Groth Detlef; Yaspo Marie-Laure; Picton Helen M; Gosden Roger G; Lehrach Hans
Primary differentiation in the human blastocyst: comparative molecular portraits of inner cell mass and trophectoderm cells.
Stem cells (Dayton, Ohio) 2005;23(10):1514-25.
2005: Papakonstantinou Eleni; Aletras Alexios J; Glass Evelyn; Tsogas Panagiotis; Dionyssopoulos Alexander; Adjaye James; Fimmel Sabine; Gouvousis Panagiotis; Herwig Ralf; Lehrach Hans; Zouboulis Christos C; Karakiulakis George
Matrix metalloproteinases of epithelial origin in facial sebum of patients with acne and their regulation by isotretinoin.
The Journal of investigative dermatology 2005;125(4):673-84.
2005: Ralser Markus; Nonhoff Ute; Albrecht Mario; Lengauer Thomas; Wanker Erich E; Lehrach Hans; Krobitsch Sylvia
Ataxin-2 and huntingtin interact with endophilin-A complexes to function in plastin-associated pathways.
Human molecular genetics 2005;14(19):2893-909.
2005: Feilner Tanja; Hultschig Claus; Lee Justin; Meyer Svenja; Immink Richard G H; Koenig Andrea; Possling Alexandra; Seitz Harald; Beveridge Allan; Scheel Dierk; Cahill Dolores J; Lehrach Hans; Kreutzberger Jürgen; Kersten Birgit
High throughput identification of potential Arabidopsis mitogen-activated protein kinases substrates.
Molecular & cellular proteomics : MCP 2005;4(10):1558-68.
2005: Stelzl Ulrich; Worm Uwe; Lalowski Maciej; Haenig Christian; Brembeck Felix H; Goehler Heike; Stroedicke Martin; Zenkner Martina; Schoenherr Anke; Koeppen Susanne; Timm Jan; Mintzlaff Sascha; Abraham Claudia; Bock Nicole; Kietzmann Silvia; Goedde Astrid; Toksöz Engin; Droege Anja; Krobitsch Sylvia; Korn Bernhard; Birchmeier Walter; Lehrach Hans; Wanker Erich E
A human protein-protein interaction network: a resource for annotating the proteome.
Cell 2005;122(6):957-68.
2005: Gade Dörte; Theiss Dorothea; Lange Daniela; Mirgorodskaya Ekaterina; Lombardot Thierry; Glöckner Frank Oliver; Kube Michael; Reinhardt Richard; Amann Rudolf; Lehrach Hans; Rabus Ralf; Gobom Johan
Towards the proteome of the marine bacterium Rhodopirellula baltica: mapping the soluble proteins.
Proteomics 2005;5(14):3654-71.
2005: Jankowski Vera; Vanholder Raymond; van der Giet Markus; Henning Lars; Tölle Markus; Schönfelder Gilbert; Krakow Anja; Karadogan Sevil; Gustavsson Niklas; Gobom Johan; Webb Jessie; Lehrach Hans; Giebing Günther; Schlüter Hartmut; Hilgers Karl F; Zidek Walter; Jankowski Joachim
Detection of angiotensin II in supernatants of stimulated mononuclear leukocytes by matrix-assisted laser desorption ionization time-of-flight/time-of-flight mass analysis.
Hypertension 2005;46(3):591-7.
2005: Gustavsson Niklas; Greber Boris; Kreitler Thomas; Himmelbauer Heinz; Lehrach Hans; Gobom Johan
A proteomic method for the analysis of changes in protein concentrations in response to systemic perturbations using metabolic incorporation of stable isotopes and mass spectrometry.
Proteomics 2005;5(14):3563-70.
2005: Lueking Angelika; Huber Otmar; Wirths Christopher; Schulte Kirsten; Stieler Karola M; Blume-Peytavi Ulrike; Kowald Axel; Hensel-Wiegel Karin; Tauber Rudolf; Lehrach Hans; Meyer Helmut E; Cahill Dolores J
Profiling of alopecia areata autoantigens based on protein microarray technology.
Molecular & cellular proteomics : MCP 2005;4(9):1382-90.
2005: Ralser Markus; Goehler Heike; Wanker Erich E; Lehrach Hans; Krobitsch Sylvia
Generation of a yeast two-hybrid strain suitable for competitive protein binding analysis.
BioTechniques 2005;39(2):165-6, 168.
2005: Costello Christine M; Mah Nancy; Häsler Robert; Rosenstiel Philip; Waetzig Georg H; Hahn Andreas; Lu Tim; Gurbuz Yesim; Nikolaus Susanna; Albrecht Mario; Hampe Jochen; Lucius Ralph; Klöppel Günther; Eickhoff Holger; Lehrach Hans; Lengauer Thomas; Schreiber Stefan
Dissection of the inflammatory bowel disease transcriptome using genome-wide cDNA microarrays.
PLoS medicine 2005;2(8):e199.
2005: Büssow Konrad; Scheich Christoph; Sievert Volker; Harttig Ulrich; Schultz Jörg; Simon Bernd; Bork Peer; Lehrach Hans; Heinemann Udo
Structural genomics of human proteins--target selection and generation of a public catalogue of expression clones.
Microbial cell factories 2005;4():21.
2005: Bürkle Lukas; Meyer Svenja; Dortay Hakan; Lehrach Hans; Heyl Alexander
In vitro recombination cloning of entire cDNA libraries in Arabidopsis thaliana and its application to the yeast two-hybrid system.
Functional & integrative genomics 2005;5(3):175-83.
2005: Birney Ewan; Ciliberto Andrea; Colding-Jørgensen Morten; Goldbeter Albert; Hohmann Stefan; Kuiper Martin; Lehrach Hans; Miczka Gisela; Mosekilde Erik; Westerhoff Hans; Wolkenhauer Olaf
Report of an EU projects workshop on systems biology held in Brussels, Belgium on 8 December 2004.
Systems biology 2005;152(2):55-60.
2005: Sauer Sascha; Lange Bodo M H; Gobom Johan; Nyarsik Lajos; Seitz Harald; Lehrach Hans
Miniaturization in functional genomics and proteomics.
Nature reviews. Genetics 2005;6(6):465-76.
2005: Steller Sigrid; Angenendt Philipp; Cahill Dolores J; Heuberger Sigrid; Lehrach Hans; Kreutzberger Jürgen
Bacterial protein microarrays for identification of new potential diagnostic markers for Neisseria meningitidis infections.
Proteomics 2005;5(8):2048-55.
2005: Greber Boris; Tandara Helena; Lehrach Hans; Himmelbauer Heinz
Comparison of PCR-based mutation detection methods and application for identification of mouse Sult1a1 mutant embryonic stem cell clones using pooled templates.
Human mutation 2005;25(5):483-90.
2005: Greber Boris; Lehrach Hans; Himmelbauer Heinz
Mouse splice mutant generation from ENU-treated ES cells--a gene-driven approach.
Genomics 2005;85(5):557-62.
2005: Giavalisco Patrick; Nordhoff Eckhard; Kreitler Thomas; Klöppel Klaus-Dieter; Lehrach Hans; Klose Joachim; Gobom Johan
Proteome analysis of Arabidopsis thaliana by two-dimensional gel electrophoresis and matrix-assisted laser desorption/ionisation-time of flight mass spectrometry.
Proteomics 2005;5(7):1902-13.
2005: Giavalisco Patrick; Wilson Daniel; Kreitler Thomas; Lehrach Hans; Klose Joachim; Gobom Johan; Fucini Paola
High heterogeneity within the ribosomal proteins of the Arabidopsis thaliana 80S ribosome.
Plant molecular biology 2005;57(4):577-91.
2005: Gutjahr Claudia; Murphy Derek; Lueking Angelika; Koenig Andrea; Janitz Michal; O'Brien John; Korn Bernhard; Horn Sabine; Lehrach Hans; Cahill Dolores J
Mouse protein arrays from a TH1 cell cDNA library for antibody screening and serum profiling.
Genomics 2005;85(3):285-96.
2005: Angenendt Philipp; Lehrach Hans; Kreutzberger Jürgen; Glökler Jörn
Subnanoliter enzymatic assays on microarrays.
Proteomics 2005;5(2):420-5.
2005: Ralser Markus; Albrecht Mario; Nonhoff Ute; Lengauer Thomas; Lehrach Hans; Krobitsch Sylvia
An integrative approach to gain insights into the cellular function of human ataxin-2.
Journal of molecular biology 2005;346(1):203-14.
2005: Mirgorodskaya Ekaterina; Braeuer Corina; Fucini Paola; Lehrach Hans; Gobom Johan
Nanoflow liquid chromatography coupled to matrix-assisted laser desorption/ionization mass spectrometry: sample preparation, data analysis, and application to the analysis of complex peptide mixtures.
Proteomics 2005;5(2):399-408.
2005: Wolski Witold E; Lalowski Maciej; Martus Peter; Herwig Ralf; Giavalisco Patrick; Gobom Johan; Sickmann Albert; Lehrach Hans; Reinert Knut
Transformation and other factors of the peptide mass spectrometry pairwise peak-list comparison process.
BMC bioinformatics 2005;6():285.
2004: Illiger J; Herwig R; Steinfath M; Przewieslik T; Elge T; Bull Ch; Radelof U; Lehrach H; Janitz M
Establishment of T cell-specific and natural killer cell-specific unigene sets: towards high-throughput genomics of leukaemia.
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics 2004;31(6):253-7.
2004: Volff Jean-Nicolas; Lehrach Hans; Reinhardt Richard; Chourrout Daniel
Retroelement dynamics and a novel type of chordate retrovirus-like element in the miniature genome of the tunicate Oikopleura dioica.
Molecular biology and evolution 2004;21(11):2022-33.
2004: Edvardsen Rolf B; Lerat Emmanuelle; Maeland Anne Dorthea; Flåt Mette; Tewari Rita; Jensen Marit F; Lehrach Hans; Reinhardt Richard; Seo Hee-Chan; Chourrout Daniel
Hypervariable and highly divergent intron-exon organizations in the chordate Oikopleura dioica.
Journal of molecular evolution 2004;59(4):448-57.
2004: Adjaye James; Herwig Ralf; Herrmann Doris; Wruck Wasco; Benkahla Alia; Brink Thore C; Nowak Monika; Carnwath Joseph W; Hultschig Claus; Niemann Heiner; Lehrach Hans
Cross-species hybridisation of human and bovine orthologous genes on high density cDNA microarrays.
BMC genomics 2004;5(1):83.
2004: Seelow Dominik; Galli Raffaello; Mebus Siegrun; Sperling Hans-Peter; Lehrach Hans; Sperling Silke
d-matrix - database exploration, visualization and analysis.
BMC bioinformatics 2004;5():168.
2004: Borodina Tatiana A; Lehrach Hans; Soldatov Aleksey V
Ligation detection reaction-TaqMan procedure for single nucleotide polymorphism detection on genomic DNA.
Analytical biochemistry 2004;333(2):309-19.
2004: Sauer Sascha; Kepper Pamela; Smyra Anett; Dahl Andreas; Ferse Falk-Thilo; Lehrach Hans; Reinhardt Richard
Automated solid-phase extraction for purification of single nucleotide polymorphism genotyping products prior to matrix-assisted laser desorption/ionisation time-of-flight mass spectrometric analysis.
Journal of chromatography. A 2004;1049(1-2):9-16.
2004: Goehler Heike; Lalowski Maciej; Stelzl Ulrich; Waelter Stephanie; Stroedicke Martin; Worm Uwe; Droege Anja; Lindenberg Katrin S; Knoblich Maria; Haenig Christian; Herbst Martin; Suopanki Jaana; Scherzinger Eberhard; Abraham Claudia; Bauer Bianca; Hasenbank Renate; Fritzsche Anja; Ludewig Andreas H; Büssow Konrad; Coleman Sarah H; Gutekunst Claire-Anne; Landwehrmeyer Bernhard G; Lehrach Hans; Wanker Erich E
A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease.
Molecular cell 2004;15(6):853-65.
2004: Seo Hee-Chan; Edvardsen Rolf Brudvik; Maeland Anne Dorthea; Bjordal Marianne; Jensen Marit Flo; Hansen Anette; Flaat Mette; Weissenbach Jean; Lehrach Hans; Wincker Patrick; Reinhardt Richard; Chourrout Daniel
Hox cluster disintegration with persistent anteroposterior order of expression in Oikopleura dioica.
Nature 2004;431(7004):67-71.
2004: Rickert Andreas M; Lehrach Hans; Sperling Silke
Multiplexed real-time PCR using universal reporters.
Clinical chemistry 2004;50(9):1680-3.
2004: Kahlem Pascal; Sultan Marc; Herwig Ralf; Steinfath Matthias; Balzereit Daniela; Eppens Barbara; Saran Nidhi G; Pletcher Mathew T; South Sarah T; Stetten Gail; Lehrach Hans; Reeves Roger H; Yaspo Marie-Laure
Transcript level alterations reflect gene dosage effects across multiple tissues in a mouse model of down syndrome.
Genome research 2004;14(7):1258-67.
2004: Poustka Albert J; Kühn Alexander; Radosavljevic Vesna; Wellenreuther Ruth; Lehrach Hans; Panopoulou Georgia
On the origin of the chordate central nervous system: expression of onecut in the sea urchin embryo.
Evolution & development 2004;6(4):227-36.
2004: Groth Detlef; Lehrach Hans; Hennig Steffen
GOblet: a platform for Gene Ontology annotation of anonymous sequence data.
Nucleic acids research 2004;32(Web Server issue):W313-7.
2004: Quiring Rebecca; Wittbrodt Beate; Henrich Thorsten; Ramialison Mirana; Burgtorf Carola; Lehrach Hans; Wittbrodt Joachim
Large-scale expression screening by automated whole-mount in situ hybridization.
Mechanisms of development 2004;121(7-8):971-6.
2004: Khorasani Maryam Zadeh; Hennig Steffen; Imre Gabriele; Asakawa Shuichi; Palczewski Stefanie; Berger Anja; Hori Hiroshi; Naruse Kiyoshi; Mitani Hiroshi; Shima Akihiro; Lehrach Hans; Wittbrodt Jochen; Kondoh Hisato; Shimizu Nobuyoshi; Himmelbauer Heinz
A first generation physical map of the medaka genome in BACs essential for positional cloning and clone-by-clone based genomic sequencing.
Mechanisms of development 2004;121(7-8):903-13.
2004: Rickert Andreas M; Borodina Tatiana A; Kuhn Eckehard J; Lehrach Hans; Sperling Silke
Refinement of single-nucleotide polymorphism genotyping methods on human genomic DNA: amplifluor allele-specific polymerase chain reaction versus ligation detection reaction-TaqMan.
Analytical biochemistry 2004;330(2):288-97.
2004: Angenendt Philipp; Wilde Jeannine; Kijanka Gregor; Baars Sabine; Cahill Dolores J; Kreutzberger Jürgen; Lehrach Hans; Konthur Zoltán; Glökler Jörn
Seeing better through a MIST: evaluation of monoclonal recombinant antibody fragments on microarrays.
Analytical chemistry 2004;76(10):2916-21.
2004: Hurt Peter; Walter Lutz; Sudbrak Ralf; Klages Sven; Müller Ines; Shiina Takashi; Inoko Hidetoshi; Lehrach Hans; Günther Eberhard; Reinhardt Richard; Himmelbauer Heinz
The genomic sequence and comparative analysis of the rat major histocompatibility complex.
Genome research 2004;14(4):631-9.
2004: Angenendt Philipp; Nyarsik Lajos; Szaflarski Witold; Glökler Jörn; Nierhaus Knud H; Lehrach Hans; Cahill Dolores J; Lueking Angelika
Cell-free protein expression and functional assay in nanowell chip format.
Analytical chemistry 2004;76(7):1844-9.
2004: Mah Nancy; Thelin Anders; Lu Tim; Nikolaus Susanna; Kühbacher Tanja; Gurbuz Yesim; Eickhoff Holger; Klöppel Günther; Lehrach Hans; Mellgård Björn; Costello Christine M; Schreiber Stefan
A comparison of oligonucleotide and cDNA-based microarray systems.
Physiological genomics 2004;16(3):361-70.
2004: Büssow Konrad; Quedenau Claudia; Sievert Volker; Tischer Janett; Scheich Christoph; Seitz Harald; Hieke Brigitte; Niesen Frank H; Götz Frank; Harttig Ulrich; Lehrach Hans
A catalog of human cDNA expression clones and its application to structural genomics.
Genome biology 2004;5(9):R71.
2004: Bauer Oliver; Guerasimova Anna; Sauer Sascha; Thamm Sabine; Steinfath Matthias; Herwig Ralf; Janitz Michal; Lehrach Hans; Radelof Uwe
Multiplexed hybridizations of positively charge-tagged peptide nucleic acids detected by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
Rapid communications in mass spectrometry : RCM 2004;18(16):1821-9.
2004: Spahn Christian M T; Lehrach Hans; Jungblut Peter R
A European focus on proteomics.
Genome biology 2004;5(5):322.
2003: Hoehe Margret R; Timmermann Bernd; Lehrach Hans
Human inter-individual DNA sequence variation in candidate genes, drug targets, the importance of haplotypes and pharmacogenomics.
Current pharmaceutical biotechnology 2003;4(6):351-78.
2003: Poustka Albert J; Groth Detlef; Hennig Steffen; Thamm Sabine; Cameron Andrew; Beck Alfred; Reinhardt Richard; Herwig Ralf; Panopoulou Georgia; Lehrach Hans
Generation, annotation, evolutionary analysis, and database integration of 20,000 unique sea urchin EST clusters.
Genome research 2003;13(12):2736-46.
2003: Burgtorf Carola; Kepper Pamela; Hoehe Margret; Schmitt Carsten; Reinhardt Richard; Lehrach Hans; Sauer Sascha
Clone-based systematic haplotyping (CSH): a procedure for physical haplotyping of whole genomes.
Genome research 2003;13(12):2717-24.
2003: Lueking Angelika; Possling Alexandra; Huber Otmar; Beveridge Allan; Horn Martin; Eickhoff Holger; Schuchardt Johannes; Lehrach Hans; Cahill Dolores J
A nonredundant human protein chip for antibody screening and serum profiling.
Molecular & cellular proteomics : MCP 2003;2(12):1342-9.
2003: Borodina Tatiana A; Lehrach Hans; Soldatov Aleksey V
DNA purification on homemade silica spin-columns.
Analytical biochemistry 2003;321(1):135-7.
2003: Busch Anne; Engemann Sabine; Lurz Rudi; Okazawa Hitoshi; Lehrach Hans; Wanker Erich E
Mutant huntingtin promotes the fibrillogenesis of wild-type huntingtin: a potential mechanism for loss of huntingtin function in Huntington's disease.
The Journal of biological chemistry 2003;278(42):41452-61.
2003: Angenendt Philipp; Glökler Jörn; Konthur Zoltán; Lehrach Hans; Cahill Dolores J
3D protein microarrays: performing multiplex immunoassays on a single chip.
Analytical chemistry 2003;75(17):4368-72.
2003: Angenendt Philipp; Glökler Jim; Sobek Jens; Lehrach Hans; Cahill Dolores J
Next generation of protein microarray support materials: evaluation for protein and antibody microarray applications.
Journal of chromatography. A 2003;1009(1-2):97-104.
2003: Grzeskowiak Rafal; Witt Henning; Drungowski Mario; Thermann Rolf; Hennig Steffen; Perrot Andreas; Osterziel Karl J; Klingbiel Dirk; Scheid Stefanie; Spang Rainer; Lehrach Hans; Ruiz Patricia
Expression profiling of human idiopathic dilated cardiomyopathy.
Cardiovascular research 2003;59(2):400-11.
2003: Kersten B; Feilner T; Kramer A; Wehrmeyer S; Possling A; Witt I; Zanor M I; Stracke R; Lueking A; Kreutzberger J; Lehrach H; Cahilll D J
Generation of Arabidopsis protein chips for antibody and serum screening.
Plant molecular biology 2003;52(5):999-1010.
2003: Hennig Steffen; Groth Detlef; Lehrach Hans
Automated Gene Ontology annotation for anonymous sequence data.
Nucleic acids research 2003;31(13):3712-5.
2003: Borodina Tatiana A; Lehrach Hans; Soldatov Aleksey V
Ligation-based synthesis of oligonucleotides with block structure.
Analytical biochemistry 2003;318(2):309-13.
2003: Panopoulou Georgia; Hennig Steffen; Groth Detlef; Krause Antje; Poustka Albert J; Herwig Ralf; Vingron Martin; Lehrach Hans
New evidence for genome-wide duplications at the origin of vertebrates using an amphioxus gene set and completed animal genomes.
Genome research 2003;13(6A):1056-66.
2003: Sauer Sascha; Lehrach Hans; Reinhardt Richard
MALDI mass spectrometry analysis of single nucleotide polymorphisms by photocleavage and charge-tagging.
Nucleic acids research 2003;31(11):e63.
2003: Kaynak Bogac; von Heydebreck Anja; Mebus Siegrun; Seelow Dominik; Hennig Steffen; Vogel Jan; Sperling Hans-Peter; Pregla Reinhard; Alexi-Meskishvili Vladimir; Hetzer Roland; Lange Peter E; Vingron Martin; Lehrach Hans; Sperling Silke
Genome-wide array analysis of normal and malformed human hearts.
Circulation 2003;107(19):2467-74.
2003: Greber Boris; Lehrach Hans; Himmelbauer Heinz
Characterization of trimethylpsoralen as a mutagen for mouse embryonic stem cells.
Mutation research 2003;525(1-2):67-76.
2003: Kodzius Rimantas; Rhyner Claudio; Konthur Zoltan; Buczek Donald; Lehrach Hans; Walter Gerald; Crameri Reto
Rapid identification of allergen-encoding cDNA clones by phage display and high-density arrays.
Combinatorial chemistry & high throughput screening 2003;6(2):147-54.
2003: Giavalisco Patrick; Nordhoff Eckhard; Lehrach Hans; Gobom Johan; Klose Joachim
Extraction of proteins from plant tissues for two-dimensional electrophoresis analysis.
Electrophoresis 2003;24(1-2):207-16.
2003: Malecová Barbora; Ramser Juliane; O'Brien John K; Janitz Michal; Júdová Jana; Lehrach Hans; Simúth Jozef
Honeybee (Apis mellifera L.) mrjp gene family: computational analysis of putative promoters and genomic structure of mrjp1, the gene coding for the most abundant protein of larval food.
Gene 2003;303():165-75.
2003: Sudbrak Ralf; Reinhardt Richard; Hennig Steffen; Lehrach Hans; Günther Eberhard; Walter Lutz
Comparative and evolutionary analysis of the rhesus macaque extended MHC class II region.
Immunogenetics 2003;54(10):699-704.
2003: Lueking Angelika; Horn Sabine; Lehrach Hans; Cahill Dolores J
A dual-expression vector allowing expression in E. coli and P. pastoris, including new modifications.
Methods in molecular biology (Clifton, N.J.) 2003;205():31-42.
2002: Herwig Ralf; Schulz Britta; Weisshaar Bernd; Hennig Steffen; Steinfath Matthias; Drungowski Mario; Stahl Dietmar; Wruck Wasco; Menze Andreas; O'Brien John; Lehrach Hans; Radelof Uwe
Construction of a 'unigene' cDNA clone set by oligonucleotide fingerprinting allows access to 25 000 potential sugar beet genes.
The Plant journal : for cell and molecular biology 2002;32(5):845-57.
2002: Gitton Yorick; Dahmane Nadia; Baik Sonya; Ruiz i Altaba Ariel; Neidhardt Lorenz; Scholze Manuela; Herrmann Bernhard G; Kahlem Pascal; Benkahla Alia; Schrinner Sabine; Yildirimman Reha; Herwig Ralf; Lehrach Hans; Yaspo Marie-Laure;
A gene expression map of human chromosome 21 orthologues in the mouse.
Nature 2002;420(6915):586-90.
2002: Heiser Volker; Engemann Sabine; Bröcker Wolfgang; Dunkel Ilona; Boeddrich Annett; Waelter Stephanie; Nordhoff Eddi; Lurz Rudi; Schugardt Nancy; Rautenberg Susanne; Herhaus Christian; Barnickel Gerhard; Böttcher Henning; Lehrach Hans; Wanker Erich E
Identification of benzothiazoles as potential polyglutamine aggregation inhibitors of Huntington's disease by using an automated filter retardation assay.
Proceedings of the National Academy of Sciences of the United States of America 2002;99 Suppl 4():16400-6.
2002: Angenendt Philipp; Glökler Jörn; Murphy Derek; Lehrach Hans; Cahill Dolores J
Toward optimized antibody microarrays: a comparison of current microarray support materials.
Analytical biochemistry 2002;309(2):253-60.
2002: Wierling Christoph K; Steinfath Matthias; Elge Thorsten; Schulze-Kremer Steffen; Aanstad Pia; Clark Matthew; Lehrach Hans; Herwig Ralf
Simulation of DNA array hybridization experiments and evaluation of critical parameters during subsequent image and data analysis.
BMC bioinformatics 2002;3():29.
2002: Fuchs Tania; Malecova Barbora; Linhart Chaim; Sharan Roded; Khen Miriam; Herwig Ralf; Shmulevich Dmitry; Elkon Rani; Steinfath Matthias; O'Brien John K; Radelof Uwe; Lehrach Hans; Lancet Doron; Shamir Ron
DEFOG: a practical scheme for deciphering families of genes.
Genomics 2002;80(3):295-302.
2002: Gobom Johan; Mueller Martin; Egelhofer Volker; Theiss Dorothea; Lehrach Hans; Nordhoff Eckhard
A calibration method that simplifies and improves accurate determination of peptide molecular masses by MALDI-TOF MS.
Analytical chemistry 2002;74(15):3915-23.
2002: Wruck Wasco; Griffiths Huw; Steinfath Matthias; Lehrach Hans; Radelof Uwe; O'Brien John
Xdigitise: visualization of hybridization experiments.
Bioinformatics (Oxford, England) 2002;18(5):757-60.
2002: Egelhofer Volker; Gobom Johan; Seitz Harald; Giavalisco Patrick; Lehrach Hans; Nordhoff Eckhard
Protein identification by MALDI-TOF-MS peptide mapping: a new strategy.
Analytical chemistry 2002;74(8):1760-71.
2002: Klose Joachim; Nock Christina; Herrmann Marion; Stühler Kai; Marcus Katrin; Blüggel Martin; Krause Eberhard; Schalkwyk Leonard C; Rastan Sohaila; Brown Steve D M; Büssow Konrad; Himmelbauer Heinz; Lehrach Hans
Genetic analysis of the mouse brain proteome.
Nature genetics 2002;30(4):385-93.
2002: Schmidt Frank; Lueking Angelika; Nordhoff Eckhard; Gobom Johan; Klose Joachim; Seitz Harald; Egelhofer Volker; Eickhoff Holger; Lehrach Hans; Cahill Dolores J
Generation of minimal protein identifiers of proteins from two-dimensional gels and recombinant proteins.
Electrophoresis 2002;23(4):621-5.
2002: Olbrich Heike; Häffner Karsten; Kispert Andreas; Völkel Alexander; Volz Andreas; Sasmaz Gürsel; Reinhardt Richard; Hennig Steffen; Lehrach Hans; Konietzko Nikolaus; Zariwala Maimoona; Noone Peadar G; Knowles Michael; Mitchison Hannah M; Meeks Maggie; Chung Eddie M K; Hildebrandt Friedhelm; Sudbrak Ralf; Omran Heymut
Mutations in DNAH5 cause primary ciliary dyskinesia and randomization of left-right asymmetry.
Nature genetics 2002;30(2):143-4.
2002: Fujiyama Asao; Watanabe Hidemi; Toyoda Atsushi; Taylor Todd D; Itoh Takehiko; Tsai Shih-Feng; Park Hong-Seog; Yaspo Marie-Laure; Lehrach Hans; Chen Zhu; Fu Gang; Saitou Naruya; Osoegawa Kazutoyo; de Jong Pieter J; Suto Yumiko; Hattori Masahira; Sakaki Yoshiyuki
Construction and analysis of a human-chimpanzee comparative clone map.
Science (New York, N.Y.) 2002;295(5552):131-4.
2002: Eickhoff Holger; Konthur Zoltán; Lueking Angelika; Lehrach Hans; Walter Gerald; Nordhoff Eckhard; Nyarsik Lajos; Büssow Konrad
Protein array technology: the tool to bridge genomics and proteomics.
Advances in biochemical engineering/biotechnology 2002;77():103-12.
2001: Seo H C; Kube M; Edvardsen R B; Jensen M F; Beck A; Spriet E; Gorsky G; Thompson E M; Lehrach H; Reinhardt R; Chourrout D
Miniature genome in the marine chordate Oikopleura dioica.
Science (New York, N.Y.) 2001;294(5551):2506.
2001: Dickmeis T; Aanstad P; Clark M; Fischer N; Herwig R; Mourrain P; Blader P; Rosa F; Lehrach H; Strähle U
Identification of nodal signaling targets by array analysis of induced complex probes.
Developmental dynamics : an official publication of the American Association of Anatomists 2001;222(4):571-80.
2001: Schalkwyk L C; Cusack B; Dunkel I; Hopp M; Kramer M; Palczewski S; Piefke J; Scheel S; Weiher M; Wenske G; Lehrach H; Himmelbauer H
Advanced integrated mouse YAC map including BAC framework.
Genome research 2001;11(12):2142-50.
2001: Herwig R; Aanstad P; Clark M; Lehrach H
Statistical evaluation of differential expression on cDNA nylon arrays with replicated experiments.
Nucleic acids research 2001;29(23):E117.
2001: Holz C; Lueking A; Bovekamp L; Gutjahr C; Bolotina N; Lehrach H; Cahill D J
A human cDNA expression library in yeast enriched for open reading frames.
Genome research 2001;11(10):1730-5.
2001: Guerasimova A; Nyarsik L; Girnus I; Steinfath M; Wruck W; Griffiths H; Herwig R; Wierling C; O'Brien J; Eickhoff H; Lehrach H; Radelof U
New tools for oligonucleotide fingerprinting.
BioTechniques 2001;31(3):490-5.
2001: Clark M D; Hennig S; Herwig R; Clifton S W; Marra M A; Lehrach H; Johnson S L; Group tW;
An oligonucleotide fingerprint normalized and expressed sequence tag characterized zebrafish cDNA library.
Genome research 2001;11(9):1594-602.
2001: Nordhoff E; Egelhofer V; Giavalisco P; Eickhoff H; Horn M; Przewieslik T; Theiss D; Schneider U; Lehrach H; Gobom J
Large-gel two-dimensional electrophoresis-matrix assisted laser desorption/ionization-time of flight-mass spectrometry: an analytical challenge for studying complex protein mixtures.
Electrophoresis 2001;22(14):2844-55.
2001: Waelter S; Scherzinger E; Hasenbank R; Nordhoff E; Lurz R; Goehler H; Gauss C; Sathasivam K; Bates G P; Lehrach H; Wanker E E
The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptin-binding protein involved in receptor-mediated endocytosis.
Human molecular genetics 2001;10(17):1807-17.
2001: Steinfath M; Wruck W; Seidel H; Lehrach H; Radelof U; O'Brien J
Automated image analysis for array hybridization experiments.
Bioinformatics (Oxford, England) 2001;17(7):634-41.
2001: Hofer E; Sobanov Y; Brostjan C; Lehrach H; Düchler M
The centromeric part of the human natural killer (NK) receptor complex: lectin-like receptor genes expressed in NK, dendritic and endothelial cells.
Immunological reviews 2001;181():5-19.
2001: Sittler A; Lurz R; Lueder G; Priller J; Lehrach H; Hayer-Hartl M K; Hartl F U; Wanker E E
Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease.
Human molecular genetics 2001;10(12):1307-15.
2001: Hüttenhofer A; Kiefmann M; Meier-Ewert S; O'Brien J; Lehrach H; Bachellerie J P; Brosius J
RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse.
The EMBO journal 2001;20(11):2943-53.
2001: Waelter S; Boeddrich A; Lurz R; Scherzinger E; Lueder G; Lehrach H; Wanker E E
Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation.
Molecular biology of the cell 2001;12(5):1393-407.
2001: Gobom J; Schuerenberg M; Mueller M; Theiss D; Lehrach H; Nordhoff E
Alpha-cyano-4-hydroxycinnamic acid affinity sample preparation. A protocol for MALDI-MS peptide analysis in proteomics.
Analytical chemistry 2001;73(3):434-8.
2001: Crameri R; Kodzius R; Konthur Z; Lehrach H; Blaser K; Walter G
Tapping allergen repertoires by advanced cloning technologies.
International archives of allergy and immunology 2001;124(1-3):43-7.
2001: Mueller U; Nyarsik L; Horn M; Rauth H; Przewieslik T; Saenger W; Lehrach H; Eickhoff H
Development of a technology for automation and miniaturization of protein crystallization.
Journal of biotechnology 2001;85(1):7-14.
2001: Sudbrak R; Wieczorek G; Nuber U A; Mann W; Kirchner R; Erdogan F; Brown C J; Wöhrle D; Sterk P; Kalscheuer V M; Berger W; Lehrach H; Ropers H H
X chromosome-specific cDNA arrays: identification of genes that escape from X-inactivation and other applications.
Human molecular genetics 2001;10(1):77-83.
2001: Omran H; Häffner K; Burth S; Fernandez C; Fargier B; Villaquiran A; Nothwang H G; Schnittger S; Lehrach H; Woo D; Brandis M; Sudbrak R; Hildebrandt F
Human adolescent nephronophthisis: gene locus synteny with polycystic kidney disease in pcy mice.
Journal of the American Society of Nephrology : JASN 2001;12(1):107-13.
2001: Büssow K; Konthur Z; Lueking A; Lehrach H; Walter G
Protein array technology. Potential use in medical diagnostics.
American journal of pharmacogenomics : genomics-related research in drug development and clinical practice 2001;1(1):37-43.
2000: Brostjan C; Sobanov Y; Glienke J; Hayer S; Lehrach H; Francis F; Hofer E
The NKG2 natural killer cell receptor family: comparative analysis of promoter sequences.
Genes and immunity 2000;1(8):504-8.
2000: Sauer S; Lechner D; Berlin K; Plançon C; Heuermann A; Lehrach H; Gut I G
Full flexibility genotyping of single nucleotide polymorphisms by the GOOD assay.
Nucleic acids research 2000;28(23):E100.
2000: Lueking A; Holz C; Gotthold C; Lehrach H; Cahill D
A system for dual protein expression in Pichia pastoris and Escherichia coli.
Protein expression and purification 2000;20(3):372-8.
2000: Gösele C; Hong L; Kreitler T; Rossmann M; Hieke B; Gross U; Kramer M; Himmelbauer H; Bihoreau M T; Kwitek-Black A E; Twigger S; Tonellato P J; Jacob H J; Schalkwyk L C; Lindpaintner K; Ganten D; Lehrach H; Knoblauch M
High-throughput scanning of the rat genome using interspersed repetitive sequence-PCR markers.
Genomics 2000;69(3):287-94.
2000: Neidhardt L; Gasca S; Wertz K; Obermayr F; Worpenberg S; Lehrach H; Herrmann B G
Large-scale screen for genes controlling mammalian embryogenesis, using high-throughput gene expression analysis in mouse embryos.
Mechanisms of development 2000;98(1-2):77-94.
2000: Shinya M; Eschbach C; Clark M; Lehrach H; Furutani-Seiki M
Zebrafish Dkk1, induced by the pre-MBT Wnt signaling, is secreted from the prechordal plate and patterns the anterior neural plate.
Mechanisms of development 2000;98(1-2):3-17.
2000: Schreiber S; Hampe J; Eickhoff H; Lehrach H
Functional genomics in gastroenterology.
Gut 2000;47(5):601-7.
2000: Herwig R; Schmitt A O; Steinfath M; O'Brien J; Seidel H; Meier-Ewert S; Lehrach H; Radelof U
Information theoretical probe selection for hybridisation experiments.
Bioinformatics (Oxford, England) 2000;16(10):890-8.
2000: Nordhoff E; Luebbert C; Thiele G; Heiser V; Lehrach H
Rapid determination of short DNA sequences by the use of MALDI-MS.
Nucleic acids research 2000;28(20):E86.
2000: Eickhoff H; Schuchhardt J; Ivanov I; Meier-Ewert S; O'Brien J; Malik A; Tandon N; Wolski E W; Rohlfs E; Nyarsik L; Reinhardt R; Nietfeld W; Lehrach H
Tissue gene expression analysis using arrayed normalized cDNA libraries.
Genome research 2000;10(8):1230-40.
2000: Schuerenberg M; Luebbert C; Eickhoff H; Kalkum M; Lehrach H; Nordhoff E
Prestructured MALDI-MS sample supports.
Analytical chemistry 2000;72(15):3436-42.
2000: Egelhofer V; Büssow K; Luebbert C; Lehrach H; Nordhoff E
Improvements in protein identification by MALDI-TOF-MS peptide mapping.
Analytical chemistry 2000;72(13):2741-50.
2000: Hartuv E; Schmitt A O; Lange J; Meier-Ewert S; Lehrach H; Shamir R
An algorithm for clustering cDNA fingerprints.
Genomics 2000;66(3):249-56.
2000: Heiser V; Scherzinger E; Boeddrich A; Nordhoff E; Lurz R; Schugardt N; Lehrach H; Wanker E E
Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: implications for Huntington's disease therapy.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(12):6739-44.
2000: Schuchhardt J; Beule D; Malik A; Wolski E; Eickhoff H; Lehrach H; Herzel H
Normalization strategies for cDNA microarrays.
Nucleic acids research 2000;28(10):E47.
2000: Büssow K; Nordhoff E; Lübbert C; Lehrach H; Walter G
A human cDNA library for high-throughput protein expression screening.
Genomics 2000;65(1):1-8.
2000: Sudbrak R; Brown J; Dobson-Stone C; Carter S; Ramser J; White J; Healy E; Dissanayake M; Larrègue M; Perrussel M; Lehrach H; Munro C S; Strachan T; Burge S; Hovnanian A; Monaco A P
Hailey-Hailey disease is caused by mutations in ATP2C1 encoding a novel Ca(2+) pump.
Human molecular genetics 2000;9(7):1131-40.
2000: Schubert M; Holland L Z; Panopoulou G D; Lehrach H; Holland N D
Characterization of amphioxus AmphiWnt8: insights into the evolution of patterning of the embryonic dorsoventral axis.
Evolution & development 2000;2(2):85-92.
2000: Sauer S; Lechner D; Berlin K; Lehrach H; Escary J L; Fox N; Gut I G
A novel procedure for efficient genotyping of single nucleotide polymorphisms.
Nucleic acids research 2000;28(5):E13.
2000: Wiles M V; Vauti F; Otte J; Füchtbauer E M; Ruiz P; Füchtbauer A; Arnold H H; Lehrach H; Metz T; von Melchner H; Wurst W
Establishment of a gene-trap sequence tag library to generate mutant mice from embryonic stem cells.
Nature genetics 2000;24(1):13-4.
2000: Himmelbauer H; Schalkwyk L C; Lehrach H
Interspersed repetitive sequence (IRS)-PCR for typing of whole genome radiation hybrid panels.
Nucleic acids research 2000;28(2):e7.
2000: Bull C; Sobanov Y; Röhrdanz B; O'Brien J; Lehrach H; Hofer E
The centromeric part of the human NK gene complex: linkage of LOX-1 and LY49L with the CD94/NKG2 region.
Genes and immunity 2000;1(4):280-7.
1999: Starikov E B; Lehrach H; Wanker E E
Folding of oligoglutamines: a theoretical approach based upon thermodynamics and molecular mechanics.
Journal of biomolecular structure & dynamics 1999;17(3):409-27.
1999: Herwig R; Poustka A J; Müller C; Bull C; Lehrach H; O'Brien J
Large-scale clustering of cDNA-fingerprinting data.
Genome research 1999;9(11):1093-105.
1999: Schalkwyk L C; Jung M; Daser A; Weiher M; Walter J; Himmelbauer H; Lehrach H
Panel of microsatellite markers for whole-genome scans and radiation hybrid mapping and a mouse family tree.
Genome research 1999;9(9):878-87.
1999: Poustka A J; Herwig R; Krause A; Hennig S; Meier-Ewert S; Lehrach H
Toward the gene catalogue of sea urchin development: the construction and analysis of an unfertilized egg cDNA library highly normalized by oligonucleotide fingerprinting.
Genomics 1999;59(2):122-33.
1999: Hollenbach B; Scherzinger E; Schweiger K; Lurz R; Lehrach H; Wanker E E
Aggregation of truncated GST-HD exon 1 fusion proteins containing normal range and expanded glutamine repeats.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1999;354(1386):991-4.
1999: Lueking A; Horn M; Eickhoff H; Büssow K; Lehrach H; Walter G
Protein microarrays for gene expression and antibody screening.
Analytical biochemistry 1999;270(1):103-11.
1999: Vente A; Korn B; Zehetner G; Poustka A; Lehrach H
Distribution and early development of microarray technology in Europe.
Nature genetics 1999;22(1):22.
1999: Nock C; Gauss C; Schalkwyk L C; Klose J; Lehrach H; Himmelbauer H
Technology development at the interface of proteome research and genomics: mapping nonpolymorphic proteins on the physical map of mouse chromosomes.
Electrophoresis 1999;20(4-5):1027-32.
1999: Boeddrich A; Burgtorf C; Francis F; Hennig S; Panopoulou G; Steffens C; Borzym K; Lehrach H
Sequence analysis of an amphioxus cosmid containing a gene homologous to members of the aldo-keto reductase gene superfamily.
Gene 1999;230(2):207-14.
1999: Hildmann T; Kong X; O'Brien J; Riesselman L; Christensen H M; Dagand E; Lehrach H; Yaspo M L
A contiguous 3-Mb sequence-ready map in the S3-MX region on 21q22.2 based on high- throughput nonisotopic library screenings.
Genome research 1999;9(4):360-72.
1999: Scherzinger E; Sittler A; Schweiger K; Heiser V; Lurz R; Hasenbank R; Bates G P; Lehrach H; Wanker E E
Self-assembly of polyglutamine-containing huntingtin fragments into amyloid-like fibrils: implications for Huntington's disease pathology.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(8):4604-9.
1999: Boeddrich A; Burgtorf C; Roest Crollius H; Hennig S; Bernot A; Clark M; Reinhardt R; Lehrach H; Francis F
Analysis of the spermine synthase gene region in Fugu rubripes, Tetraodon fluviatilis, and Danio rerio.
Genomics 1999;57(1):164-8.
1999: Gauss C; Kalkum M; Löwe M; Lehrach H; Klose J
Analysis of the mouse proteome. (I) Brain proteins: separation by two-dimensional electrophoresis and identification by mass spectrometry and genetic variation.
Electrophoresis 1999;20(3):575-600.
1999: Seranski P; Heiss N S; Dhorne-Pollet S; Radelof U; Korn B; Hennig S; Backes E; Schmidt S; Wiemann S; Schwarz C E; Lehrach H; Poustka A
Transcription mapping in a medulloblastoma breakpoint interval and Smith-Magenis syndrome candidate region: identification of 53 transcriptional units and new candidate genes.
Genomics 1999;56(1):1-11.
1999: Blechschmidt K; Schweiger M; Wertz K; Poulson R; Christensen H M; Rosenthal A; Lehrach H; Yaspo M L
The mouse Aire gene: comparative genomic sequencing, gene organization, and expression.
Genome research 1999;9(2):158-66.
1999: Rinderle C; Christensen H M; Schweiger S; Lehrach H; Yaspo M L
AIRE encodes a nuclear protein co-localizing with cytoskeletal filaments: altered sub-cellular distribution of mutants lacking the PHD zinc fingers.
Human molecular genetics 1999;8(2):277-90.
1999: Sobanov Y; Glienke J; Brostjan C; Lehrach H; Francis F; Hofer E
Linkage of the NKG2 and CD94 receptor genes to D12S77 in the human natural killer gene complex.
Immunogenetics 1999;49(2):99-105.
1999: Leser U; Roest Crollius H; Lehrach H; Sudbrak R
IXDB, an X chromosome integrated database (update).
Nucleic acids research 1999;27(1):123-7.
1999: Wanker E E; Scherzinger E; Heiser V; Sittler A; Eickhoff H; Lehrach H
Membrane filter assay for detection of amyloid-like polyglutamine-containing protein aggregates.
Methods in enzymology 1999;309():375-86.
1999: Clark M D; Panopoulou G D; Cahill D J; Büssow K; Lehrach H
Construction and analysis of arrayed cDNA libraries.
Methods in enzymology 1999;303():205-33.
1998: Zechner U; Scheel S; Hemberger M; Hopp M; Haaf T; Fundele R; Wanker E E; Lehrach H; Wedemeyer N; Himmelbauer H
Characterization of the mouse Src homology 3 domain gene Sh3d2c on Chr 7 demonstrates coexpression with huntingtin in the brain and identifies the processed pseudogene Sh3d2c-ps1 on Chr 2.
Genomics 1998;54(3):505-10.
1998: Radelof U; Hennig S; Seranski P; Steinfath M; Ramser J; Reinhardt R; Poustka A; Francis F; Lehrach H
Preselection of shotgun clones by oligonucleotide fingerprinting: an efficient and high throughput strategy to reduce redundancy in large-scale sequencing projects.
Nucleic acids research 1998;26(23):5358-64.
1998: Büssow K; Cahill D; Nietfeld W; Bancroft D; Scherzinger E; Lehrach H; Walter G
A method for global protein expression and antibody screening on high-density filters of an arrayed cDNA library.
Nucleic acids research 1998;26(21):5007-8.
1998: Sittler A; Wälter S; Wedemeyer N; Hasenbank R; Scherzinger E; Eickhoff H; Bates G P; Lehrach H; Wanker E E
SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates.
Molecular cell 1998;2(4):427-36.
1998: Schalkwyk L C; Weiher M; Kirby M; Cusack B; Himmelbauer H; Lehrach H
Refined radiation hybrid map of mouse chromosome 17.
Mammalian genome : official journal of the International Mammalian Genome Society 1998;9(10):807-11.
1998: Burgtorf C; Welzel K; Hasenbank R; Zehetner G; Weis S; Lehrach H
Gridded genomic libraries of different chordate species: a reference library system for basic and comparative genetic studies of chordate genomes.
Genomics 1998;52(2):230-2.
1998: Panopoulou G D; Clark M D; Holland L Z; Lehrach H; Holland N D
AmphiBMP2/4, an amphioxus bone morphogenetic protein closely related to Drosophila decapentaplegic and vertebrate BMP2 and BMP4: insights into evolution of dorsoventral axis specification.
Developmental dynamics : an official publication of the American Association of Anatomists 1998;213(1):130-9.
1998: Glienke J; Sobanov Y; Brostjan C; Steffens C; Nguyen C; Lehrach H; Hofer E; Francis F
The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex.
Immunogenetics 1998;48(3):163-73.
1998: Himmelbauer H; Dunkel I; Otto G W; Burgtorf C; Schalkwyk L C; Lehrach H
Complex probes for high-throughput parallel genetic mapping of genomic mouse BAC clones.
Mammalian genome : official journal of the International Mammalian Genome Society 1998;9(8):611-6.
1998: Tait D; Riccio M; Sittler A; Scherzinger E; Santi S; Ognibene A; Maraldi N M; Lehrach H; Wanker E E
Ataxin-3 is transported into the nucleus and associates with the nuclear matrix.
Human molecular genetics 1998;7(6):991-7.
1998: Georgalis Y; Starikov E B; Hollenbach B; Lurz R; Scherzinger E; Saenger W; Lehrach H; Wanker E E
Huntingtin aggregation monitored by dynamic light scattering.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(11):6118-21.
1998: Meier-Ewert S; Lange J; Gerst H; Herwig R; Schmitt A; Freund J; Elge T; Mott R; Herrmann B; Lehrach H
Comparative gene expression profiling by oligonucleotide fingerprinting.
Nucleic acids research 1998;26(9):2216-23.
1998: Bertaux F; Sharp A H; Ross C A; Lehrach H; Bates G P; Wanker E
HAP1-huntingtin interactions do not contribute to the molecular pathology in Huntington's disease transgenic mice.
FEBS letters 1998;426(2):229-32.
1998: Beye M; Poch A; Burgtorf C; Moritz R F; Lehrach H
A gridded genomic library of the honeybee (Apis mellifera): a reference library system for basic and comparative genetic studies of a hymenopteran genome.
Genomics 1998;49(2):317-20.
1998: Rodríguez A; Carretero M; Glienke J; Bellón T; Ramírez A; Lehrach H; Francis F; López-Botet M
Structure of the human CD94 C-type lectin gene.
Immunogenetics 1998;47(4):305-9.
1998: Lorenz B; Francis F; Gempel K; Böddrich A; Josten M; Schmahl W; Schmidt J; Lehrach H; Meitinger T; Strom T M
Spermine deficiency in Gy mice caused by deletion of the spermine synthase gene.
Human molecular genetics 1998;7(3):541-7.
1998: Dahmane N; Ghezala G A; Gosset P; Chamoun Z; Dufresne-Zacharia M C; Lopes C; Rabatel N; Gassanova-Maugenre S; Chettouh Z; Abramowski V; Fayet E; Yaspo M L; Korn B; Blouin J L; Lehrach H; Poutska A; Antonarakis S E; Sinet P M; Créau N; Delabar J M
Transcriptional map of the 2.5-Mb CBR-ERG region of chromosome 21 involved in Down syndrome.
Genomics 1998;48(1):12-23.
1998: Himmelbauer H; Wedemeyer N; Haaf T; Wanker E E; Schalkwyk L C; Lehrach H
IRS-PCR-based genetic mapping of the huntingtin interacting protein gene (HIP1) on mouse chromosome 5.
Mammalian genome : official journal of the International Mammalian Genome Society 1998;9(1):26-31.
1998: Leser U; Wagner R; Grigoriev A; Lehrach H; Roest Crollius H
IXDB, an X chromosome integrated database.
Nucleic acids research 1998;26(1):108-11.
1998: Leser U; Lehrach H; Roest Crollius H
Issues in developing integrated genomic databases and application to the human X chromosome.
Bioinformatics (Oxford, England) 1998;14(7):583-90.
1998: Grigoriev A; Levin A; Lehrach H
A distributed environment for physical map construction.
Bioinformatics (Oxford, England) 1998;14(3):252-8.
1997: Wedemeyer N; Peoples R; Himmelbauer H; Lehrach H; Francke U; Wanker E E
Localization of the human HIP1 gene close to the elastin (ELN) locus on 7q11.23.
Genomics 1997;46(2):313-5.
1997: Sathasivam K; Baxendale S; Mangiarini L; Bertaux F; Hetherington C; Kanazawa I; Lehrach H; Bates G P
Aberrant processing of the Fugu HD (FrHD) mRNA in mouse cells and in transgenic mice.
Human molecular genetics 1997;6(12):2141-9.
1997: Bancroft D R; O'Brien J K; Guerasimova A; Lehrach H
Simplified handling of high-density genetic filters using rigid plastic laminates.
Nucleic acids research 1997;25(20):4160-1.
1997: Gosset P; Ghezala G A; Korn B; Yaspo M L; Poutska A; Lehrach H; Sinet P M; Créau N
A new inward rectifier potassium channel gene (KCNJ15) localized on chromosome 21 in the Down syndrome chromosome region 1 (DCR1).
Genomics 1997;44(2):237-41.
1997: Holland N D; Zhang S C; Clark M; Panopoulou G; Lehrach H; Holland L Z
Sequence and developmental expression of AmphiTob, an amphioxus homolog of vertebrate Tob in the PC3/BTG1/Tob family of tumor suppressor genes.
Developmental dynamics : an official publication of the American Association of Anatomists 1997;210(1):11-8.
1997: Scherzinger E; Lurz R; Turmaine M; Mangiarini L; Hollenbach B; Hasenbank R; Bates G P; Davies S W; Lehrach H; Wanker E E
Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo.
Cell 1997;90(3):549-58.
1997: Francis F; Strom T M; Hennig S; Böddrich A; Lorenz B; Brandau O; Mohnike K L; Cagnoli M; Steffens C; Klages S; Borzym K; Pohl T; Oudet C; Econs M J; Rowe P S; Reinhardt R; Meitinger T; Lehrach H
Genomic organization of the human PEX gene mutated in X-linked dominant hypophosphatemic rickets.
Genome research 1997;7(6):573-85.
1997: Crnogorac-Jurcevic T; Brown J R; Lehrach H; Schalkwyk L C
Tetraodon fluviatilis, a new puffer fish model for genome studies.
Genomics 1997;41(2):177-84.
1997: Rowe P S; Oudet C L; Francis F; Sinding C; Pannetier S; Econs M J; Strom T M; Meitinger T; Garabedian M; David A; Macher M A; Questiaux E; Popowska E; Pronicka E; Read A P; Mokrzycki A; Glorieux F H; Drezner M K; Hanauer A; Lehrach H; Goulding J N; O'Riordan J L
Distribution of mutations in the PEX gene in families with X-linked hypophosphataemic rickets (HYP).
Human molecular genetics 1997;6(4):539-49.
1997: Wanker E E; Rovira C; Scherzinger E; Hasenbank R; Wälter S; Tait D; Colicelli J; Lehrach H
HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system.
Human molecular genetics 1997;6(3):487-95.
1997: Strom T M; Francis F; Lorenz B; Böddrich A; Econs M J; Lehrach H; Meitinger T
Pex gene deletions in Gy and Hyp mice provide mouse models for X-linked hypophosphatemia.
Human molecular genetics 1997;6(2):165-71.
1996: Mangiarini L; Sathasivam K; Seller M; Cozens B; Harper A; Hetherington C; Lawton M; Trottier Y; Lehrach H; Davies S W; Bates G P
Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice.
Cell 1996;87(3):493-506.
1996: Roest Crollius H; Ross M T; Grigoriev A; Knights C J; Holloway E; Misfud J; Li K; Playford M; Gregory S G; Humphray S J; Coffey A J; See C G; Marsh S; Vatcheva R; Kumlien J; Labella T; Lam V; Rak K H; Todd K; Mott R; Graeser D; Rappold G; Zehetner G; Poustka A; Bentley D R; Monaco A P; Lehrach H
An integrated YAC map of the human X chromosome.
Genome research 1996;6(10):943-55.
1996: Kumlien J; Grigoriev A; Roest Crollius H; Ross M; Goodfellow P N; Lehrach H
A radiation hybrid map spanning the entire human X chromosome integrating YACs, genes, and STS markers.
Mammalian genome : official journal of the International Mammalian Genome Society 1996;7(10):758-66.
1996: Tomlinson A M; Cox R D; Lehrach H R; Dalrymple M A
Restriction map of two yeast artificial chromosomes spanning the murine casein locus.
Mammalian genome : official journal of the International Mammalian Genome Society 1996;7(7):542-4.
1996: Osoegawa K; Susukida R; Okano S; Kato Y; Lehrach H; Nizetic D; Soeda E
Potential CpG-rich islands clustering around single-minded gene in Down syndrome chromosomal region.
Mammalian genome : official journal of the International Mammalian Genome Society 1996;7(6):461-3.
1996: Hunter K W; Riba L; Schalkwyk L; Clark M; Resenchuk S; Beeghly A; Su J; Tinkov F; Lee P; Ramu E; Lehrach H; Housman D
Toward the construction of integrated physical and genetic maps of the mouse genome using interspersed repetitive sequence PCR (IRS-PCR) genomics.
Genome research 1996;6(4):290-9.
1996: Osoegawa K; Susukida R; Okano S; Kudoh J; Minoshima S; Shimizu N; de Jong P J; Groet J; Ives J; Lehrach H; Nizetic D; Soeda E
An integrated map with cosmid/PAC contigs of a 4-Mb Down syndrome critical region.
Genomics 1996;32(3):375-87.
1996: Rowe P S; Goulding J N; Francis F; Oudet C; Econs M J; Hanauer A; Lehrach H; Read A P; Mountford R C; Summerfield T; Weissenbach J; Fraser W; Drezner M K; Davies K E; O'Riordan J L
The gene for X-linked hypophosphataemic rickets maps to a 200-300kb region in Xp22.1, and is located on a single YAC containing a putative vitamin D response element (VDRE).
Human genetics 1996;97(3):345-52.
1996: Gregorová S; Mnuková-Fajdelová M; Trachtulec Z; Capková J; Loudová M; Hoglund M; Hamvas R; Lehrach H; Vincek V; Klein J; Forejt J
Sub-milliMorgan map of the proximal part of mouse Chromosome 17 including the hybrid sterility 1 gene.
Mammalian genome : official journal of the International Mammalian Genome Society 1996;7(2):107-13.
1996: Larin Z; Monaco A P; Lehrach H
Generation of large insert YAC libraries.
Methods in molecular biology (Clifton, N.J.) 1996;54():1-11.
1995: Newell W R; Mott R; Beck S; Lehrach H
Construction of genetic maps using distance geometry.
Genomics 1995;30(1):59-70.
1995: Scholler P; Karger A E; Meier-Ewert S; Lehrach H; Delius H; Hoheisel J D
Fine-mapping of shotgun template-libraries; an efficient strategy for the systematic sequencing of genomic DNA.
Nucleic acids research 1995;23(19):3842-9.
1995: Hummerich H; Lehrach H
Trinucleotide repeat expansion and human disease.
Electrophoresis 1995;16(9):1698-704.
1995: Hamvas R M; Lehrach H R
Repetitive sequence fingerprinting in the long range mapping of mammalian genomes.
Electrophoresis 1995;16(9):1602-6.
1995: Yaspo M L; Gellen L; Mott R; Korn B; Nizetic D; Poustka A M; Lehrach H
Model for a transcript map of human chromosome 21: isolation of new coding sequences from exon and enriched cDNA libraries.
Human molecular genetics 1995;4(8):1291-304.
1995: Sutherland H F; Pick E; Francis F; Lehrach H; Frischauf A M
Mapping around the Fused locus on mouse chromosome 17.
Mammalian genome : official journal of the International Mammalian Genome Society 1995;6(7):449-53.
1995: Jones E P; Xiao H; Schultz R A; Flaherty L; Trachtulec Z; Vincek V; Larin Z; Lehrach H; Lindahl K F
MHC class I gene organization in > 1.5-Mb YAC contigs from the H2-M region.
Genomics 1995;27(1):40-51.
1995: Schalkwyk L C; Francis F; Lehrach H
Techniques in mammalian genome mapping.
Current opinion in biotechnology 1995;6(1):37-43.
1994: Höglund M; Lehrach H
The construction of a beta-lactamase-encoding ApR gene cassette flanked by recognition sites for NotI, SacII, MluI, SplI, BssHII and NarI.
Gene 1994;150(1):193-4.
1994: Nizetic D; Monard S; Young B; Cotter F; Zehetner G; Lehrach H
Construction of cosmid libraries from flow-sorted human chromosomes 1, 6, 7, 11, 13, and 18 for reference library resources.
Mammalian genome : official journal of the International Mammalian Genome Society 1994;5(12):801-2.
1994: Trachtulec Z; Vincek V; Hamvas R M; Forejt J; Lehrach H; Klein J
Physical map of mouse chromosome 17 in the region relevant for positional cloning of the Hybrid sterility 1 gene.
Genomics 1994;23(1):132-7.
1994: Maier E; Roest Crollius H; Lehrach H
Hybridisation techniques on gridded high density DNA and in situ colony filters based on fluorescence detection.
Nucleic acids research 1994;22(16):3423-4.
1994: Grigoriev A; Mott R; Lehrach H
An algorithm to detect chimeric clones and random noise in genomic mapping.
Genomics 1994;22(2):482-6.
1994: Kumlien J; Labella T; Zehetner G; Vatcheva R; Nizetic D; Lehrach H
Efficient identification and regional positioning of YAC and cosmid clones to human chromosome 21 by radiation fusion hybrids.
Mammalian genome : official journal of the International Mammalian Genome Society 1994;5(6):365-71.
1994: Monaco A P; Larin Z; Lehrach H
Construction of yeast artificial chromosome libraries by pulsed-field gel electrophoresis.
Molecular biotechnology 1994;1(3):241-9.
1994: Maier E; Meier-Ewert S; Ahmadi A R; Curtis J; Lehrach H
Application of robotic technology to automated sequence fingerprint analysis by oligonucleotide hybridisation.
Journal of biotechnology 1994;35(2-3):191-203.
1994: Hoheisel J D; Ross M T; Zehetner G; Lehrach H
Relational genome analysis using reference libraries and hybridisation fingerprinting.
Journal of biotechnology 1994;35(2-3):121-34.
1994: Cox R D; Shedlovsky A; Hamvas R; Goldsworthy M; Whittington J; Connelly C S; Dove W F; Lehrach H
A 1.2-Mb YAC contig spans the quaking region.
Genomics 1994;21(1):77-84.
1994: Francis F; Rowe P S; Econs M J; See C G; Benham F; O'Riordan J L; Drezner M K; Hamvas R M; Lehrach H
A YAC contig spanning the hypophosphatemic rickets disease gene (HYP) candidate region.
Genomics 1994;21(1):229-37.
1994: Hamvas R M; Francis F; Cox R D; Nizetic D; Goldsworthy M E; Brown S D; Lehrach H R
Rapid restriction analysis of YAC clones.
Nucleic acids research 1994;22(7):1318-9.
1994: Econs M J; Francis F; Rowe P S; Speer M C; O'Riordan J L; Lehrach H; Becker P A
Dinucleotide repeat polymorphism at the DXS1683 locus.
Human molecular genetics 1994;3(4):680.
1994: Bates G; Lehrach H
Trinucleotide repeat expansions and human genetic disease.
BioEssays : news and reviews in molecular, cellular and developmental biology 1994;16(4):277-84.
1994: Gibson F; Lehrach H; Buckler A J; Brown S D; North M A
Isolation of conserved sequences from yeast artificial chromosomes by exon amplification.
BioTechniques 1994;16(3):453-8.
1994: Rowe P S; Goulding J; Read A; Lehrach H; Francis F; Hanauer A; Oudet C; Biancalana V; Kooh S W; Davies K E
Refining the genetic map for the region flanking the X-linked hypophosphataemic rickets locus (Xp22.1-22.2).
Human genetics 1994;93(3):291-4.
1994: Francis F; Benham F; See C G; Fox M; Ishikawa-Brush Y; Monaco A P; Weiss B; Rappold G; Hamvas R M; Lehrach H
Identification of YAC and cosmid clones encompassing the ZFX-POLA region using irradiation hybrid cell lines.
Genomics 1994;20(1):75-83.
1994: Zehetner G; Lehrach H
The Reference Library System--sharing biological material and experimental data.
Nature 1994;367(6462):489-91.
1994: Ambrose C M; Duyao M P; Barnes G; Bates G P; Lin C S; Srinidhi J; Baxendale S; Hummerich H; Lehrach H; Altherr M
Structure and expression of the Huntington's disease gene: evidence against simple inactivation due to an expanded CAG repeat.
Somatic cell and molecular genetics 1994;20(1):27-38.
1994: Vetrie D; Kendall E; Coffey A; Hassock S; Collins J; Todd C; Lehrach H; Bobrow M; Bentley D R; Harris A
A 6.5-Mb yeast artificial chromosome contig incorporating 33 DNA markers on the human X chromosome at Xq22.
Genomics 1994;19(1):42-7.
1994: Hummerich H; Baxendale S; Mott R; Kirby S F; MacDonald M E; Gusella J; Lehrach H; Bates G P
Distribution of trinucleotide repeat sequences across a 2 Mbp region containing the Huntington's disease gene.
Human molecular genetics 1994;3(1):73-8.
1994: Francis F; Zehetner G; Höglund M; Lehrach H
Construction and preliminary analysis of the ICRF human P1 library.
Genetic analysis, techniques and applications 1994;11(5-6):148-57.
1993: Cox R D; Whittington J; Shedlovsky A; Connelly C S; Dove W F; Goldsworthy M; Larin Z; Lehrach H
Detailed physical and genetic mapping in the region of plasminogen, D17Rp17e, and quaking.
Mammalian genome : official journal of the International Mammalian Genome Society 1993;4(12):687-94.
1993: Tommerup N; Aagaard L; Lund C L; Boel E; Baxendale S; Bates G P; Lehrach H; Vissing H
A zinc-finger gene ZNF141 mapping at 4p16.3/D4S90 is a candidate gene for the Wolf-Hirschhorn (4p-) syndrome.
Human molecular genetics 1993;2(10):1571-5.
1993: Schedl A; Larin Z; Montoliu L; Thies E; Kelsey G; Lehrach H; Schütz G
A method for the generation of YAC transgenic mice by pronuclear microinjection.
Nucleic acids research 1993;21(20):4783-7.
1993: North M A; Sanseau P; Buckler A J; Church D; Jackson A; Patel K; Trowsdale J; Lehrach H
Efficiency and specificity of gene isolation by exon amplification.
Mammalian genome : official journal of the International Mammalian Genome Society 1993;4(9):466-74.
1993: Rowe P S; Goulding J; Read A; Mountford R; Hanauer A; Oudet C; Whyte M P; Meier-Ewert S; Lehrach H; Davies K E
New markers for linkage analysis of X-linked hypophosphataemic rickets.
Human genetics 1993;91(6):571-5.
1993: Hoheisel J D; Lehrach H
Use of reference libraries and hybridisation fingerprinting for relational genome analysis.
FEBS letters 1993;325(1-2):118-22.
1993: Yaspo M L; North M A; Lehrach H
Exon-enriched probe derived from a human chromosome 21 YAC by exon-amplification.
Nucleic acids research 1993;21(9):2271-2.
1993: Bates G; Lehrach H
The Huntington disease gene--still a needle in a haystack?
Human molecular genetics 1993;2(4):343-7.
1993: Mott R; Grigoriev A; Maier E; Hoheisel J; Lehrach H
Algorithms and software tools for ordering clone libraries: application to the mapping of the genome of Schizosaccharomyces pombe.
Nucleic acids research 1993;21(8):1965-74.
1993: Hoheisel J D; Maier E; Mott R; McCarthy L; Grigoriev A V; Schalkwyk L C; Nizetic D; Francis F; Lehrach H
High resolution cosmid and P1 maps spanning the 14 Mb genome of the fission yeast S. pombe.
Cell 1993;73(1):109-20.
1993: Meier-Ewert S; Maier E; Ahmadi A; Curtis J; Lehrach H
An automated approach to generating expressed sequence catalogues.
Nature 1993;361(6410):375-6.
1993: Cox R D; Meier-Ewert S; Ross M; Larin Z; Monaco A P; Lehrach H
Genome mapping and cloning of mutations using yeast artificial chromosomes.
Methods in enzymology 1993;225():637-53.
1993: Larin Z; Monaco A P; Meier-Ewert S; Lehrach H
Construction and characterization of yeast artificial chromosome libraries from the mouse genome.
Methods in enzymology 1993;225():623-37.
1993: Hadano S; Ishida Y; Bates G P; Nagayama T; Kanazawa I; Lehrach H; Ikeda J
Generation of high-density DNA markers from yeast artificial chromosome DNA by single unique primer-polymerase chain reaction.
Genetic analysis, techniques and applications 1993;10(5):105-8.
1993: Hoheisel J D; Maier E; Meier-Ewert S; Lehrach H
Relational genome analysis based on hybridisation techniques.
Annales de biologie clinique 1993;51(9):827-9.
1993: Montoliu L; Schedl A; Kelsey G; Lichter P; Larin Z; Lehrach H; Schütz G
Generation of transgenic mice with yeast artificial chromosomes.
Cold Spring Harbor symposia on quantitative biology 1993;58():55-62.
1992: Baldini A; Ross M; Nizetic D; Vatcheva R; Lindsay E A; Lehrach H; Siniscalco M
Chromosomal assignment of human YAC clones by fluorescence in situ hybridization: use of single-yeast-colony PCR and multiple labeling.
Genomics 1992;14(1):181-4.
1992: Korn B; Sedlacek Z; Manca A; Kioschis P; Konecki D; Lehrach H; Poustka A
A strategy for the selection of transcribed sequences in the Xq28 region.
Human molecular genetics 1992;1(4):235-42.
1992: Maier E; Hoheisel J D; McCarthy L; Mott R; Grigoriev A V; Monaco A P; Larin Z; Lehrach H
Complete coverage of the Schizosaccharomyces pombe genome in yeast artificial chromosomes.
Nature genetics 1992;1(4):273-7.
1992: Monaco A P; Walker A P; Millwood I; Larin Z; Lehrach H
A yeast artificial chromosome contig containing the complete Duchenne muscular dystrophy gene.
Genomics 1992;12(3):465-73.
1992: Gress T M; Hoheisel J D; Lennon G G; Zehetner G; Lehrach H
Hybridization fingerprinting of high-density cDNA-library arrays with cDNA pools derived from whole tissues.
Mammalian genome : official journal of the International Mammalian Genome Society 1992;3(11):609-19.
1991: Monaco A P; Müller U; Larin Z; Meier-Ewert S; Lehrach H
Isolation of the human sex determining region from a Y-enriched yeast artificial chromosome library.
Genomics 1991;11(4):1049-53.
1991: Baxendale S; Bates G P; MacDonald M E; Gusella J F; Lehrach H
The direct screening of cosmid libraries with YAC clones.
Nucleic acids research 1991;19(23):6651.
1991: Drmanac R; Nizetic D; Lennon G G; Beitverda A; Lehrach H
W (A or T) sequences as probes and primers suitable for genomic mapping and fingerprinting.
Nucleic acids research 1991;19(21):5839-42.
1991: Poustka A; Dietrich A; Langenstein G; Toniolo D; Warren S T; Lehrach H
Physical map of human Xq27-qter: localizing the region of the fragile X mutation.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(19):8302-6.
1991: MacDonald M E; Lin C; Srinidhi L; Bates G; Altherr M; Whaley W L; Lehrach H; Wasmuth J; Gusella J F
Complex patterns of linkage disequilibrium in the Huntington disease region.
American journal of human genetics 1991;49(4):723-34.
1991: Lin C S; Altherr M; Bates G; Whaley W L; Read A P; Harris R; Lehrach H; Wasmuth J J; Gusella J F; MacDonald M E
New DNA markers in the Huntington's disease gene candidate region.
Somatic cell and molecular genetics 1991;17(5):481-8.
1991: Lennon G G; Drmanac R; Lehrach H
Easy removal of oil from microtiter dishes following PCR.
BioTechniques 1991;11(2):185.
1991: Hoheisel J D; Lennon G G; Zehetner G; Lehrach H
Use of high coverage reference libraries of Drosophila melanogaster for relational data analysis. A step towards mapping and sequencing of the genome.
Journal of molecular biology 1991;220(4):903-14.
1991: MacDonald M E; Scott H S; Whaley W L; Pohl T; Wasmuth J J; Lehrach H; Morris C P; Frischauf A M; Hopwood J J; Gusella J F
Huntington disease-linked locus D4S111 exposed as the alpha-L-iduronidase gene.
Somatic cell and molecular genetics 1991;17(4):421-5.
1991: Bates G P; MacDonald M E; Baxendale S; Youngman S; Lin C; Whaley W L; Wasmuth J J; Gusella J F; Lehrach H
Defined physical limits of the Huntington disease gene candidate region.
American journal of human genetics 1991;49(1):7-16.
1991: Cox R D; Copeland N G; Jenkins N A; Lehrach H
Interspersed repetitive element polymerase chain reaction product mapping using a mouse interspecific backcross.
Genomics 1991;10(2):375-84.
1991: Monaco A P; Lam V M; Zehetner G; Lennon G G; Douglas C; Nizetic D; Goodfellow P N; Lehrach H
Mapping irradiation hybrids to cosmid and yeast artificial chromosome libraries by direct hybridization of Alu-PCR products.
Nucleic acids research 1991;19(12):3315-8.
1991: Larin Z; Monaco A P; Lehrach H
Yeast artificial chromosome libraries containing large inserts from mouse and human DNA.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(10):4123-7.
1991: Nizetic D; Zehetner G; Monaco A P; Gellen L; Young B D; Lehrach H
Construction, arraying, and high-density screening of large insert libraries of human chromosomes X and 21: their potential use as reference libraries.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(8):3233-7.
1991: Cox R D; Lehrach H
Genome mapping: PCR based meiotic and somatic cell hybrid analysis.
BioEssays : news and reviews in molecular, cellular and developmental biology 1991;13(4):193-8.
1991: Nizetic D; Drmanac R; Lehrach H
An improved bacterial colony lysis procedure enables direct DNA hybridisation using short (10, 11 bases) oligonucleotides to cosmids.
Nucleic acids research 1991;19(1):182.
1990: Hoheisel J D; Lehrach H
Quantitative measurements on the duplex stability of 2,6-diaminopurine and 5-chloro-uracil nucleotides using enzymatically synthesized oligomers.
FEBS letters 1990;274(1-2):103-6.
1990: Hoheisel J D; Craig A G; Lehrach H
Effect of 5-bromo- and 5-methyldeoxycytosine on duplex stability and discrimination of the NotI octadeoxynucleotide. Quantitative measurements using thin-layer chromatography.
The Journal of biological chemistry 1990;265(27):16656-60.
1990: Stubbs L; Poustka A; Baron A; Lehrach H; Lonai P; Duboule D
The murine genes Hox-5.1 and Hox-4.1 belong to the same HOX complex on chromosome 2.
Genomics 1990;7(3):422-7.
1990: Stubbs L; Kraus J; Lehrach H
The alpha-A-crystallin and cystathionine beta-synthase genes are physically very closely linked in proximal mouse chromosome 17.
Genomics 1990;7(2):284-8.
1990: Craig A G; Nizetic D; Hoheisel J D; Zehetner G; Lehrach H
Ordering of cosmid clones covering the herpes simplex virus type I (HSV-I) genome: a test case for fingerprinting by hybridisation.
Nucleic acids research 1990;18(9):2653-60.
1990: Stubbs L; Huxley C; Hogan B; Evans T; Fried M; Duboule D; Lehrach H
The HOX-5 and surfeit gene clusters are linked in the proximal portion of mouse chromosome 2.
Genomics 1990;6(4):645-50.
1989: Hoheisel J D; Nizetic D; Lehrach H
Control of partial digestion combining the enzymes dam methylase and MboI.
Nucleic acids research 1989;17(23):9571-82.
1989: Craig A G; Nizetic D; Lehrach H
Labelling oligonucleotides to high specific activity (I).
Nucleic acids research 1989;17(12):4605-10.
1988: Burmeister M; Lehrach H
Jekyll, a family of phage-plasmid shuttle vectors.
Gene 1988;73(1):245-50.
1988: Rappold G A; Lehrach H
A long range restriction map of the pseudoautosomal region by partial digest PFGE analysis from the telomere.
Nucleic acids research 1988;16(12):5361-77.
1988: Burmeister M; Monaco A P; Gillard E F; van Ommen G J; Affara N A; Ferguson-Smith M A; Kunkel L M; Lehrach H
A 10-megabase physical map of human Xp21, including the Duchenne muscular dystrophy gene.
Genomics 1988;2(3):189-202.
1988: Gilliam T C; Gusella J F; Lehrach H
Molecular genetic strategies to investigate Huntington's disease.
Advances in neurology 1988;48():17-29.
1987: Michiels F; Craig A G; Zehetner G; Smith G P; Lehrach H
Molecular approaches to genome analysis: a strategy for the construction of ordered overlapping clone libraries.
Computer applications in the biosciences : CABIOS 1987;3(3):203-10.
1987: Rappold G A; Stubbs L; Labeit S; Crkvenjakov R B; Lehrach H
Identification of a testis-specific gene from the mouse t-complex next to a CpG-rich island.
The EMBO journal 1987;6(7):1975-80.
1987: Búcan M; Herrmann B G; Frischauf A M; Bautch V L; Bode V; Silver L M; Martin G R; Lehrach H
Deletion and duplication of DNA sequences is associated with the embryonic lethal phenotype of the t9 complementation group of the mouse t complex.
Genes & development 1987;1(4):376-85.
1987: Poustka A; Pohl T M; Barlow D P; Frischauf A M; Lehrach H
Construction and use of human chromosome jumping libraries from NotI-digested DNA.
Nature 1987;325(6102):353-5.
1987: Ehrich E; Craig A; Poustka A; Frischauf A M; Lehrach H
A family of cosmid vectors with the multi-copy R6K replication origin.
Gene 1987;57(2-3):229-37.
1986: Poustka A; Pohl T; Barlow D P; Zehetner G; Craig A; Michiels F; Ehrich E; Frischauf A M; Lehrach H
Molecular approaches to mammalian genetics.
Cold Spring Harbor symposia on quantitative biology 1986;51 Pt 1():131-9.
1985: Rackwitz H R; Zehetner G; Murialdo H; Delius H; Chai J H; Poustka A; Frischauf A; Lehrach H
Analysis of cosmids using linearization by phage lambda terminase.
Gene 1985;40(2-3):259-66.
1984: Rackwitz H R; Zehetner G; Frischauf A M; Lehrach H
Rapid restriction mapping of DNA cloned in lambda phage vectors.
Gene 1984;30(1-3):195-200.
1984: Poustka A; Rackwitz H R; Frischauf A M; Hohn B; Lehrach H
Selective isolation of cosmid clones by homologous recombination in Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(13):4129-33.

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