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Robert Lehrer

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Chemicals & Drugs

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TOP 3
Robert I Lehrer; Alexander M Cole; Michael E Selsted
θ-Defensins: cyclic peptides with endless potential.
Hiutung Chu; Maarten F de Jong; Grace Jung; Robert I Lehrer; Wuyuan Lu; Sean-Paul Nuccio; Marzena Pazgier; Nita H Salzman; Bo Shen; Renée M Tsolis; Mark A Underwood; Jan Wehkamp; Maria G Winter; Sebastian E Winter; Glenn M Young; Andreas J Baumler; Patricia A Castillo; Charles L Bevins
Human α-defensin 6 promotes mucosal innate immunity through self-assembled peptide nanonets.
Susan L Welkos; Joel Bozue; C K Cote; U Hahn; J Jedermann; G Jung; Robert I Lehrer; P Pratikhya; P Ruchala; O Shastak; T Tang; W Beyer
Humanized theta-defensins (retrocyclins) enhance macrophage performance and protect mice from experimental anthrax infections.

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All Publications

2012: Robert I Lehrer; Alexander M Cole; Michael E Selsted
θ-Defensins: cyclic peptides with endless potential.
The Journal of biological chemistry 2012;287(32):27014-9.
2012: Hiutung Chu; Maarten F de Jong; Grace Jung; Robert I Lehrer; Wuyuan Lu; Sean-Paul Nuccio; Marzena Pazgier; Nita H Salzman; Bo Shen; Renée M Tsolis; Mark A Underwood; Jan Wehkamp; Maria G Winter; Sebastian E Winter; Glenn M Young; Andreas J Baumler; Patricia A Castillo; Charles L Bevins
Human α-defensin 6 promotes mucosal innate immunity through self-assembled peptide nanonets.
Science (New York, N.Y.) 2012;337(6093):477-81.
2011: Susan L Welkos; Joel Bozue; C K Cote; U Hahn; J Jedermann; G Jung; Robert I Lehrer; P Pratikhya; P Ruchala; O Shastak; T Tang; W Beyer
Humanized theta-defensins (retrocyclins) enhance macrophage performance and protect mice from experimental anthrax infections.
Antimicrobial agents and chemotherapy 2011;55(9):4238-50.
2010: Christin Stegemann; Elena V Tsvetkova; Galina M Aleshina; Robert I Lehrer; Vladimir N Kokryakov; Ralf Hoffmann
De novo sequencing of two new cyclic theta-defensins from baboon (Papio hamadryas) leukocytes by matrix-assisted laser desorption/ionization mass spectrometry.
Rapid communications in mass spectrometry : RCM 2010;24(5):599-604.
2010: Piotr Ruchala; Mohamad Navab; Chun-Ling Jung; Susan Hama-Levy; Ewa D Micewicz; Hai Luong; Jonathan E Reyles; Shantanu Sharma; Alan J Waring; Alan M Fogelman; Robert I Lehrer
Oxpholipin 11D: an anti-inflammatory peptide that binds cholesterol and oxidized phospholipids.
PloS one 2010;5(4):e10181.
2009: Robert I Lehrer; Grace Jung; Piotr Ruchala; Wei Wang; Ewa D Micewicz; Alan J Waring; Eugene J Gillespie; Kenneth A Bradley; Adam J Ratner; Richard F Rest; Wuyuan Lu
Human alpha-defensins inhibit hemolysis mediated by cholesterol-dependent cytolysins.
Infection and immunity 2009;77(9):4028-40.
2009: Mohamad Navab; Piotr Ruchala; Alan J Waring; Robert I Lehrer; Susan Hama; Greg Hough; Mayakonda N Palgunachari; Gm Anantharamaiah; Alan M Fogelman
A novel method for oral delivery of apolipoprotein mimetic peptides synthesized from all L-amino acids.
Journal of lipid research 2009;50(8):1538-47.
2009: Robert I Lehrer; Grace Jung; Piotr Ruchala; Sabine Andre; Hans J Gabius; Wuyuan Lu
Multivalent binding of carbohydrates by the human alpha-defensin, HD5.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(1):480-90.
2008: Brian J Van Lenten; Alan C Wagner; Chun-Ling Jung; Piotr Ruchala; Alan J Waring; Robert I Lehrer; Andrew D Watson; Susan Hama; Mohamad Navab; Gm Anantharamaiah; Alan M Fogelman
Anti-inflammatory apoA-I-mimetic peptides bind oxidized lipids with much higher affinity than human apoA-I.
Journal of lipid research 2008;49(11):2302-11.
2008: Ming Tang; Alan J Waring; Robert I Lehrer; Mei Hong
Effects of guanidinium-phosphate hydrogen bonding on the membrane-bound structure and activity of an arginine-rich membrane peptide from solid-state NMR spectroscopy.
Angewandte Chemie (International ed. in English) 2008;47(17):3202-5.
2007: Mirella Salvatore; Adolfo Garcia-Sastre; Piotr Ruchala; Robert I Lehrer; Theresa Chang; Mary E Klotman
alpha-Defensin inhibits influenza virus replication by cell-mediated mechanism(s).
The Journal of infectious diseases 2007;196(6):835-43.
2007: Qiuwei Wang; Wei Wang; Junying Zheng; Sina Tabibian; Yiming Xie; Jun Song; Alan J Waring; Robert Chiu; Otto O Yang; Irvin S Y Chen; Robert I Lehrer; Shen Pang
Paradoxical effects of two theta-defensins on HIV type 1 infection.
AIDS research and human retroviruses 2007;23(4):508-14.
2007: Robert I Lehrer
Multispecific myeloid defensins.
Current opinion in hematology 2007;14(1):16-21.
2006: Ehsan Hazrati; Benjamin Galen; Wuyuan Lu; Wei Wang; Yan Ouyang; Marla Keller; Robert I Lehrer; Betsy C Herold
Human alpha- and beta-defensins block multiple steps in herpes simplex virus infection.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(12):8658-66.
2006: Rajeswari Mani; Sarah D Cady; Ming Tang; Alan J Waring; Robert I Lehrer; Mei Hong
Membrane-dependent oligomeric structure and pore formation of a beta-hairpin antimicrobial peptide in lipid bilayers from solid-state NMR.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(44):16242-7.
2006: Wei Wang; Chandrika Mulakala; Sabrina C Ward; Grace Jung; Hai Luong; Duy Pham; Alan J Waring; Yiannis N Kaznessis; Wuyuan Lu; Kenneth A Bradley; Robert I Lehrer
Retrocyclins kill bacilli and germinating spores of Bacillus anthracis and inactivate anthrax lethal toxin.
The Journal of biological chemistry 2006;281(43):32755-64.
2006: E V Tsvetkova; Galina M Aleshina; Olga Shamova; L E Leonova; Robert I Lehrer; Vladimir N Kokryakov
alpha-Defensins from blood leukocytes of the monkey Papio hamadryas.
Biochemistry. Biokhimii͡a 2006;71(8):879-83.
2006: Ming Tang; Alan J Waring; Robert I Lehrer; Mei Hong
Orientation of a beta-hairpin antimicrobial peptide in lipid bilayers from two-dimensional dipolar chemical-shift correlation NMR.
Biophysical journal 2006;90(10):3616-24.
2005: Minnie John; Marla Keller; Ehsan H Fam; Natalia Cheshenko; Kathleen Hogarty; Andrea Kasowitz; Sylvan Wallenstein; Maria Josefina Carlucci; Ana C Tuyama; Wuyuan Lu; Mary E Klotman; Robert I Lehrer; Betsy C Herold
Cervicovaginal secretions contribute to innate resistance to herpes simplex virus infection.
The Journal of infectious diseases 2005;192(10):1731-40.
2005: Rajeswari Mani; Alan J Waring; Robert I Lehrer; Mei Hong
Membrane-disruptive abilities of beta-hairpin antimicrobial peptides correlate with conformation and activity: a 31P and 1H NMR study.
Biochimica et biophysica acta 2005;1716(1):11-8.
2005: Robert I Lehrer
In defense of skin.
The Journal of investigative dermatology 2005;125(1):viii-ix; discussion x-xi.
2004: Rajeswari Mani; Jarrod J Buffy; Alan J Waring; Robert I Lehrer; Mei Hong
Solid-state NMR investigation of the selective disruption of lipid membranes by protegrin-1.
Biochemistry 2004;43(43):13839-48.
2004: Sherry Owen; Donna L Rudolph; Wei Wang; Alexander M Cole; Alan J Waring; Renu B Lal; Robert I Lehrer
RC-101, a retrocyclin-1 analogue with enhanced activity against primary HIV type 1 isolates.
AIDS research and human retroviruses 2004;20(11):1157-65.
2004: Jarrod J Buffy; Melissa J McCormick; Sungsool Wi; Alan J Waring; Robert I Lehrer; Mei Hong
Solid-state NMR investigation of the selective perturbation of lipid bilayers by the cyclic antimicrobial peptide RTD-1.
Biochemistry 2004;43(30):9800-12.
2004: Wei Wang; Sherry Owen; Donna L Rudolph; Alexander M Cole; Teresa Hong; Alan J Waring; Renu B Lal; Robert I Lehrer
Activity of alpha- and theta-defensins against primary isolates of HIV-1.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(1):515-20.
2004: Sherry Owen; Donna L Rudolph; Wei Wang; Alexander M Cole; M A Sherman; Alan J Waring; Robert I Lehrer; Renu B Lal
A theta-defensin composed exclusively of D-amino acids is active against HIV-1.
The journal of peptide research : official journal of the American Peptide Society 2004;63(6):469-76.
2004: Bushra Yasin; Wei Wang; Mabel Pang; Natalia Cheshenko; Teresa Hong; Alan J Waring; Betsy C Herold; Elizabeth A Wagar; Robert I Lehrer
Theta defensins protect cells from infection by herpes simplex virus by inhibiting viral adhesion and entry.
Journal of virology 2004;78(10):5147-56.
2003: Jarrod J Buffy; Alan J Waring; Robert I Lehrer; Mei Hong
Immobilization and aggregation of the antimicrobial peptide protegrin-1 in lipid bilayers investigated by solid-state NMR.
Biochemistry 2003;42(46):13725-34.
2003: David L Cox; Yongcheng Sun; Hsi Liu; Robert I Lehrer; William M Shafer
Susceptibility of Treponema pallidum to host-derived antimicrobial peptides.
Peptides 2003;24(11):1741-6.
2003: Tung X Nguyen; Alexander M Cole; Robert I Lehrer
Evolution of primate theta-defensins: a serpentine path to a sweet tooth.
Peptides 2003;24(11):1647-54.
2003: Jarrod J Buffy; Teresa Hong; Satoru Yamaguchi; Alan J Waring; Robert I Lehrer; Mei Hong
Solid-state NMR investigation of the depth of insertion of protegrin-1 in lipid bilayers using paramagnetic Mn2+.
Biophysical journal 2003;85(4):2363-73.
2003: Wei Wang; Alexander M Cole; Teresa Hong; Alan J Waring; Robert I Lehrer
Retrocyclin, an antiretroviral theta-defensin, is a lectin.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(9):4708-16.
2003: J Andy Tincu; Lorenzo P Menzel; Rustam Azimov; Jennifer Sands; Teresa Hong; Alan J Waring; Steven W Taylor; Robert I Lehrer
Plicatamide, an antimicrobial octapeptide from Styela plicata hemocytes.
The Journal of biological chemistry 2003;278(15):13546-53.
2003: Robert I Lehrer; Lorenzo P Menzel; Steven W Taylor; J Andrew Tincu; Alan J Waring
Natural Peptide antibiotics from tunicates: structures, functions and potential uses.
Integrative and comparative biology 2003;43(2):313-22.
2003: Bushra Yasin; Mabel Pang; Robert I Lehrer; Elizabeth A Wagar
Activity of Novispirin G-10, a novel antimicrobial peptide against Chlamydia trachomatis and vaginosis-associated bacteria.
Experimental and molecular pathology 2003;74(2):190-5.
2003: Sara Sinha; Natalia Cheshenko; Robert I Lehrer; Betsy C Herold
NP-1, a rabbit alpha-defensin, prevents the entry and intercellular spread of herpes simplex virus type 2.
Antimicrobial agents and chemotherapy 2003;47(2):494-500.
2003: Alexander M Cole; Robert I Lehrer
Minidefensins: antimicrobial peptides with activity against HIV-1.
Current pharmaceutical design 2003;9(18):1463-73.
2002: Bushra Yasin; Mabel Pang; Elizabeth A Wagar; Robert I Lehrer
Examination of Chlamydia trachomatis infection in environments mimicking normal and abnormal vaginal pH.
Sexually transmitted diseases 2002;29(9):514-9.
2002: Satoru Yamaguchi; Teresa Hong; Alan J Waring; Robert I Lehrer; Mei Hong
Solid-state NMR investigations of peptide-lipid interaction and orientation of a beta-sheet antimicrobial peptide, protegrin.
Biochemistry 2002;41(31):9852-62.
2002: Lorenzo P Menzel; In Hee Lee; Birgitta Sjostrand; Robert I Lehrer
Immunolocalization of clavanins in Styela clava hemocytes.
Developmental and comparative immunology 2002;26(6):505-15.
2002: Lars Steinstraesser; Brian F Tack; Alan J Waring; Teresa Hong; Lee Ming Boo; Ming-Hui Fan; Daniel Remick; Grace L Su; Robert I Lehrer; Stewart C Wang
Activity of novispirin G10 against Pseudomonas aeruginosa in vitro and in infected burns.
Antimicrobial agents and chemotherapy 2002;46(6):1837-44.
2002: Dmitri S Orlov; Tung Nguyen; Robert I Lehrer
Potassium release, a useful tool for studying antimicrobial peptides.
Journal of microbiological methods 2002;49(3):325-8.
2002: Monali V Sawai; Alan J Waring; William R Kearney; Paul B McCray; William R Forsyth; Robert I Lehrer; Brian F Tack
Impact of single-residue mutations on the structure and function of ovispirin/novispirin antimicrobial peptides.
Protein engineering 2002;15(3):225-32.
2002: Alexander M Cole; Teresa Hong; Lee Ming Boo; Tung Nguyen; Chengquan Zhao; Gregory Bristol; Jerome A Zack; Alan J Waring; Otto O Yang; Robert I Lehrer
Retrocyclin: a primate peptide that protects cells from infection by T- and M-tropic strains of HIV-1.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(4):1813-8.
2002: Brian F Tack; Monali V Sawai; William R Kearney; Andrew D Robertson; Mark A Sherman; Wei Wang; Teresa Hong; Lee Ming Boo; Huiyuan Wu; Alan J Waring; Robert I Lehrer
SMAP-29 has two LPS-binding sites and a central hinge.
European journal of biochemistry / FEBS 2002;269(4):1181-9.
2002: Robert I Lehrer; Tomas Ganz
Defensins of vertebrate animals.
Current opinion in immunology 2002;14(1):96-102.
2002: Ben J Glasgow; Adil R Abduragimov; Oktay K Gassymov; Kym F Faull; Taleh N Yusifov; Robert I Lehrer
Characterization of a lipophilin in rabbit tears.
Advances in experimental medicine and biology 2002;506(Pt A):573-80.
2002: Mark T Albrecht; Wei Wang; Olga Shamova; Robert I Lehrer; Neal L Schiller
Binding of protegrin-1 to Pseudomonas aeruginosa and Burkholderia cepacia.
Respiratory research 2002;3():18.
2001: In Hee Lee; Chengquan Zhao; T Nguyen; Lorenzo P Menzel; Alan J Waring; Mark A Sherman; Robert I Lehrer
Clavaspirin, an antibacterial and haemolytic peptide from Styela clava.
The journal of peptide research : official journal of the American Peptide Society 2001;58(6):445-56.
2001: Satoru Yamaguchi; Daniel Huster; Alan J Waring; Robert I Lehrer; William R Kearney; Brian F Tack; Mei Hong
Orientation and dynamics of an antimicrobial peptide in the lipid bilayer by solid-state NMR spectroscopy.
Biophysical journal 2001;81(4):2203-14.
2001: Chengquan Zhao; Tung Nguyen; Lee Ming Boo; Teresa Hong; C Espiritu; D Orlov; W Wang; Alan J Waring; Robert I Lehrer
RL-37, an alpha-helical antimicrobial peptide of the rhesus monkey.
Antimicrobial agents and chemotherapy 2001;45(10):2695-702.
2001: L Leonova; Vladimir N Kokryakov; Galina M Aleshina; Teresa Hong; Tung Nguyen; Chengquan Zhao; Alan J Waring; Robert I Lehrer
Circular minidefensins and posttranslational generation of molecular diversity.
Journal of leukocyte biology 2001;70(3):461-4.
2001: In Hee Lee; Young Shin Lee; Chong Han Kim; C R Kim; Teresa Hong; Lorenzo P Menzel; Lee Ming Boo; J Pohl; Mark A Sherman; Alan J Waring; Robert I Lehrer
Dicynthaurin: an antimicrobial peptide from hemocytes of the solitary tunicate, Halocynthia aurantium.
Biochimica et biophysica acta 2001;1527(3):141-8.
2001: Chengquan Zhao; Tung Nguyen; Lide Liu; Randy E Sacco; Kim A Brogden; Robert I Lehrer
Gallinacin-3, an inducible epithelial beta-defensin in the chicken.
Infection and immunity 2001;69(4):2684-91.
2001: Robert I Lehrer; In Hee Lee; Lorenzo P Menzel; Alan J Waring; Chengquan Zhao
Clavanins and styelins, alpha-helical antimicrobial peptides from the hemocytes of Styela clava.
Advances in experimental medicine and biology 2001;484():71-6.
2000: Steven W Taylor; A Grey Craig; Wolfgang H Fischer; M Park; Robert I Lehrer
Styelin D, an extensively modified antimicrobial peptide from ascidian hemocytes.
The Journal of biological chemistry 2000;275(49):38417-26.
2000: D Tanaka; KT Miyasaki; Robert I Lehrer
Sensitivity of Actinobacillus actinomycetemcomitans and Capnocytophaga spp. to the bactericidal action of LL-37: a cathelicidin found in human leukocytes and epithelium.
Oral microbiology and immunology 2000;15(4):226-31.
2000: Sue M Travis; N N Anderson; William R Forsyth; C Espiritu; B D Conway; E Peter Greenberg; Paul B McCray; Robert I Lehrer; Michael J Welsh; Brian F Tack
Bactericidal activity of mammalian cathelicidin-derived peptides.
Infection and immunity 2000;68(5):2748-55.
2000: Bushra Yasin; Mabel Pang; J S Turner; Y Cho; NN Dinh; Alan J Waring; Robert I Lehrer; Elizabeth A Wagar
Evaluation of the inactivation of infectious Herpes simplex virus by host-defense peptides.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 2000;19(3):187-94.
2000: Robert I Lehrer; T Nguyen; C Zhao; C X Ha; Ben J Glasgow
Secretory lipophilins: a tale of two species.
Annals of the New York Academy of Sciences 2000;923():59-67.
1999: Chengquan Zhao; Tung Nguyen; Lide Liu; Olga Shamova; Kim A Brogden; Robert I Lehrer
Differential expression of caprine beta-defensins in digestive and respiratory tissues.
Infection and immunity 1999;67(11):6221-4.
1999: Y Sokolov; TA Mirzabekov; D W Martin; Robert I Lehrer; Bruce L Kagan
Membrane channel formation by antimicrobial protegrins.
Biochimica et biophysica acta 1999;1420(1-2):23-9.
1999: Olga Shamova; Kim A Brogden; Chengquan Zhao; Tung Nguyen; Vladimir N Kokryakov; Robert I Lehrer
Purification and properties of proline-rich antimicrobial peptides from sheep and goat leukocytes.
Infection and immunity 1999;67(8):4106-11.
1999: Tomas Ganz; Robert I Lehrer
Antibiotic peptides from higher eukaryotes: biology and applications.
Molecular medicine today 1999;5(7):292-7.
1999: C Zhao; T Nguyen; Taleh N Yusifov; Ben J Glasgow; Robert I Lehrer
Lipophilins: human peptides homologous to rat prostatein.
Biochemical and biophysical research communications 1999;256(1):147-55.
1999: Robert I Lehrer; Tomas Ganz
Antimicrobial peptides in mammalian and insect host defence.
Current opinion in immunology 1999;11(1):23-7.
1998: J Turner; Y Cho; NN Dinh; Alan J Waring; Robert I Lehrer
Activities of LL-37, a cathelin-associated antimicrobial peptide of human neutrophils.
Antimicrobial agents and chemotherapy 1998;42(9):2206-14.
1998: Robert I Lehrer; G Xu; Adil R Abduragimov; NN Dinh; XD Qu; D Martin; Ben J Glasgow
Lipophilin, a novel heterodimeric protein of human tears.
FEBS letters 1998;432(3):163-7.
1998: XD Qu; Robert I Lehrer
Secretory phospholipase A2 is the principal bactericide for staphylococci and other gram-positive bacteria in human tears.
Infection and immunity 1998;66(6):2791-7.
1998: Y Cho; J S Turner; NN Dinh; Robert I Lehrer
Activity of protegrins against yeast-phase Candida albicans.
Infection and immunity 1998;66(6):2486-93.
1998: KT Miyasaki; Robert I Lehrer
Beta-sheet antibiotic peptides as potential dental therapeutics.
International journal of antimicrobial agents 1998;9(4):269-80.
1998: KT Miyasaki; R Iofel; A Oren; T Huynh; Robert I Lehrer
Killing of Fusobacterium nucleatum, Porphyromonas gingivalis and Prevotella intermedia by protegrins.
Journal of periodontal research 1998;33(2):91-8.
1998: Tomas Ganz; Robert I Lehrer
Antimicrobial peptides of vertebrates.
Current opinion in immunology 1998;10(1):41-4.
1997: In Hee Lee; Y Cho; Robert I Lehrer
Styelins, broad-spectrum antimicrobial peptides from the solitary tunicate, Styela clava.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 1997;118(3):515-21.
1997: KT Miyasaki; R Iofel; Robert I Lehrer
Sensitivity of periodontal pathogens to the bactericidal activity of synthetic protegrins, antibiotic peptides derived from porcine leukocytes.
Journal of dental research 1997;76(8):1453-9.
1997: Chengquan Zhao; L Liaw; In Hee Lee; Robert I Lehrer
cDNA cloning of three cecropin-like antimicrobial peptides (Styelins) from the tunicate, Styela clava.
FEBS letters 1997;412(1):144-8.
1997: In Hee Lee; Y Cho; Robert I Lehrer
Effects of pH and salinity on the antimicrobial properties of clavanins.
Infection and immunity 1997;65(7):2898-903.
1997: Chengquan Zhao; L Liaw; In Hee Lee; Robert I Lehrer
cDNA cloning of Clavanins: antimicrobial peptides of tunicate hemocytes.
FEBS letters 1997;410(2-3):490-2.
1997: XD Qu; SS Harwig; William M Shafer; Robert I Lehrer
Protegrin structure and activity against Neisseria gonorrhoeae.
Infection and immunity 1997;65(2):636-9.
1997: In Hee Lee; Chengquan Zhao; Y Cho; SS Harwig; Edwin L Cooper; Robert I Lehrer
Clavanins, alpha-helical antimicrobial peptides from tunicate hemocytes.
FEBS letters 1997;400(2):158-62.
1997: VN Kokriakov; V E Stefanov; Galina M Aleshina; Olga Shamova; Elena A Korneva; SS Harwig; Robert I Lehrer
[Defensins and antibiotic peptides related to them in the evolution of animal protective systems].
Zhurnal evoliutsionnoĭ biokhimii i fiziologii 1997;33(1):109-23.
1997: Tomas Ganz; Robert I Lehrer
Antimicrobial peptides of leukocytes.
Current opinion in hematology 1997;4(1):53-8.
1996: XD Qu; K C Kent Lloyd; J H Walsh; Robert I Lehrer
Secretion of type II phospholipase A2 and cryptdin by rat small intestinal Paneth cells.
Infection and immunity 1996;64(12):5161-5.
1996: Chengquan Zhao; I Wang; Robert I Lehrer
Widespread expression of beta-defensin hBD-1 in human secretory glands and epithelial cells.
FEBS letters 1996;396(2-3):319-22.
1996: B Yasin; Robert I Lehrer; S S Harwig; Elizabeth A Wagar
Protegrins: structural requirements for inactivating elementary bodies of Chlamydia trachomatis.
Infection and immunity 1996;64(11):4863-6.
1996: Robert I Lehrer; Tomas Ganz
Endogenous vertebrate antibiotics. Defensins, protegrins, and other cysteine-rich antimicrobial peptides.
Annals of the New York Academy of Sciences 1996;797():228-39.
1996: S S Harwig; A Waring; H J Yang; Y Cho; L Tan; Robert I Lehrer
Intramolecular disulfide bonds enhance the antimicrobial and lytic activities of protegrins at physiological sodium chloride concentrations.
European journal of biochemistry / FEBS 1996;240(2):352-7.
1996: Richard Fahrner; Thorsten Dieckmann; S S Harwig; Robert I Lehrer; David Eisenberg; Juli Feigon
Solution structure of protegrin-1, a broad-spectrum antimicrobial peptide from porcine leukocytes.
Chemistry & biology 1996;3(7):543-50.
1996: XD Qu; S S Harwig; A M Oren; William M Shafer; Robert I Lehrer
Susceptibility of Neisseria gonorrhoeae to protegrins.
Infection and immunity 1996;64(4):1240-5.
1996: Y Miyakawa; P Ratnakar; A G Rao; M L Costello; O Mathieu-Costello; Robert I Lehrer; A Catanzaro
In vitro activity of the antimicrobial peptides human and rabbit defensins and porcine leukocyte protegrin against Mycobacterium tuberculosis.
Infection and immunity 1996;64(3):926-32.
1996: B Yasin; S S Harwig; Robert I Lehrer; Elizabeth A Wagar
Susceptibility of Chlamydia trachomatis to protegrins and defensins.
Infection and immunity 1996;64(3):709-13.
1995: Chengquan Zhao; Tomas Ganz; Robert I Lehrer
Structures of genes for two cathelin-associated antimicrobial peptides: prophenin-2 and PR-39.
FEBS letters 1995;376(3):130-4.
1995: E Martin; Tomas Ganz; Robert I Lehrer
Defensins and other endogenous peptide antibiotics of vertebrates.
Journal of leukocyte biology 1995;58(2):128-36.
1995: Chengquan Zhao; Tomas Ganz; Robert I Lehrer
The structure of porcine protegrin genes.
FEBS letters 1995;368(2):197-202.
1995: S S Harwig; K M Swiderek; T D Lee; Robert I Lehrer
Determination of disulphide bridges in PG-2, an antimicrobial peptide from porcine leukocytes.
Journal of peptide science : an official publication of the European Peptide Society 1995;1(3):207-15.
1995: Tomas Ganz; Robert I Lehrer
Defensins.
Pharmacology & therapeutics 1995;66(2):191-205.
1995: S S Harwig; Vladimir N Kokryakov; K M Swiderek; Galina M Aleshina; Chengquan Zhao; Robert I Lehrer
Prophenin-1, an exceptionally proline-rich antimicrobial peptide from porcine leukocytes.
FEBS letters 1995;362(1):65-9.
1995: S S Harwig; L Tan; X D Qu; Y Cho; P B Eisenhauer; Robert I Lehrer
Bactericidal properties of murine intestinal phospholipase A2.
The Journal of clinical investigation 1995;95(2):603-10.
1995: S S Harwig; P B Eisenhauer; N P Chen; Robert I Lehrer
Cryptdins: endogenous antibiotic peptides of small intestinal Paneth cells.
Advances in experimental medicine and biology 1995;371A():251-5.
1994: Tomas Ganz; Robert I Lehrer
Defensins.
Current opinion in immunology 1994;6(4):584-9.
1994: Chengquan Zhao; L Liu; Robert I Lehrer
Identification of a new member of the protegrin family by cDNA cloning.
FEBS letters 1994;346(2-3):285-8.
1994: M A Couto; Lide Liu; Robert I Lehrer; Tomas Ganz
Inhibition of intracellular Histoplasma capsulatum replication by murine macrophages that produce human defensin.
Infection and immunity 1994;62(6):2375-8.
1994: S S Harwig; K M Swiderek; Vladimir N Kokryakov; L Tan; T D Lee; E A Panyutich; Galina M Aleshina; Olga Shamova; Robert I Lehrer
Gallinacins: cysteine-rich antimicrobial peptides of chicken leukocytes.
FEBS letters 1994;342(3):281-5.
1994: Bruce L Kagan; Tomas Ganz; Robert I Lehrer
Defensins: a family of antimicrobial and cytotoxic peptides.
Toxicology 1994;87(1-3):131-49.
1994: S S Harwig; Tomas Ganz; Robert I Lehrer
Neutrophil defensins: purification, characterization, and antimicrobial testing.
Methods in enzymology 1994;236():160-72.
1993: A R Murthy; Robert I Lehrer; S S Harwig; KT Miyasaki
In vitro candidastatic properties of the human neutrophil calprotectin complex.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(11):6291-301.
1993: Vladimir N Kokryakov; S S Harwig; E A Panyutich; A A Shevchenko; Galina M Aleshina; Olga Shamova; H A Korneva; Robert I Lehrer
Protegrins: leukocyte antimicrobial peptides that combine features of corticostatic defensins and tachyplesins.
FEBS letters 1993;327(2):231-6.
1993: Pieter S Hiemstra; P B Eisenhauer; S S Harwig; MT van den Barselaar; Ralph van Furth; Robert I Lehrer
Antimicrobial proteins of murine macrophages.
Infection and immunity 1993;61(7):3038-46.
1993: M A Couto; S S Harwig; Robert I Lehrer
Selective inhibition of microbial serine proteases by eNAP-2, an antimicrobial peptide from equine neutrophils.
Infection and immunity 1993;61(7):2991-4.
1993: S S Harwig; N P Chen; A S Park; Robert I Lehrer
Purification of cysteine-rich bioactive peptides from leukocytes by continuous acid-urea-polyacrylamide gel electrophoresis.
Analytical biochemistry 1993;208(2):382-6.
1993: KT Miyasaki; A L Bodeau; A R Murthy; Robert I Lehrer
In vitro antimicrobial activity of the human neutrophil cytosolic S-100 protein complex, calprotectin, against Capnocytophaga sputigena.
Journal of dental research 1993;72(2):517-23.
1993: Robert I Lehrer; A K Lichtenstein; Tomas Ganz
Defensins: antimicrobial and cytotoxic peptides of mammalian cells.
Annual review of immunology 1993;11():105-28.
1992: M A Couto; S S Harwig; James S Cullor; J P Hughes; Robert I Lehrer
eNAP-2, a novel cysteine-rich bactericidal peptide from equine leukocytes.
Infection and immunity 1992;60(12):5042-7.
1992: K Ogata; B A Linzer; R I Zuberi; Tomas Ganz; Robert I Lehrer; A Catanzaro
Activity of defensins from human neutrophilic granulocytes against Mycobacterium avium-Mycobacterium intracellulare.
Infection and immunity 1992;60(11):4720-5.
1992: P B Eisenhauer; S S Harwig; Robert I Lehrer
Cryptdins: antimicrobial defensins of the murine small intestine.
Infection and immunity 1992;60(9):3556-65.
1992: P B Eisenhauer; Robert I Lehrer
Mouse neutrophils lack defensins.
Infection and immunity 1992;60(8):3446-7.
1992: M A Couto; S S Harwig; James S Cullor; J P Hughes; Robert I Lehrer
Identification of eNAP-1, an antimicrobial peptide from equine neutrophils.
Infection and immunity 1992;60(8):3065-71.
1992: S S Harwig; A S Park; Robert I Lehrer
Characterization of defensin precursors in mature human neutrophils.
Blood 1992;79(6):1532-7.
1992: Tomas Ganz; A Oren; Robert I Lehrer
Defensins: microbicidal and cytotoxic peptides of mammalian host defense cells.
Medical microbiology and immunology 1992;181(2):99-105.
1992: Robert I Lehrer; Tomas Ganz
Defensins: endogenous antibiotic peptides from human leukocytes.
Ciba Foundation symposium 1992;171():276-90; discussion 290-3.
1991: A V Panyutich; N N Voitenok; Robert I Lehrer; Tomas Ganz
An enzyme immunoassay for human defensins.
Journal of immunological methods 1991;141(2):149-55.
1991: L A Borenstein; Tomas Ganz; S Sell; Robert I Lehrer; James N Miller
Contribution of rabbit leukocyte defensins to the host response in experimental syphilis.
Infection and immunity 1991;59(4):1368-77.
1991: L A Borenstein; Michael Selsted; Robert I Lehrer; James N Miller
Antimicrobial activity of rabbit leukocyte defensins against Treponema pallidum subsp. pallidum.
Infection and immunity 1991;59(4):1359-67.
1991: Robert I Lehrer; M Rosenman; S S Harwig; R Jackson; P Eisenhauer
Ultrasensitive assays for endogenous antimicrobial polypeptides.
Journal of immunological methods 1991;137(2):167-73.
1991: Robert I Lehrer; Tomas Ganz; Michael Selsted
Defensins: endogenous antibiotic peptides of animal cells.
Cell 1991;64(2):229-30.
1990: Robert I Lehrer; Tomas Ganz
Antimicrobial polypeptides of human neutrophils.
Blood 1990;76(11):2169-81.
1990: KT Miyasaki; A L Bodeau; Tomas Ganz; Michael Selsted; Robert I Lehrer
In vitro sensitivity of oral, gram-negative, facultative bacteria to the bactericidal activity of human neutrophil defensins.
Infection and immunity 1990;58(12):3934-40.
1990: P Eisenhauer; S S Harwig; D Szklarek; Tomas Ganz; Robert I Lehrer
Polymorphic expression of defensins in neutrophils from outbred rats.
Infection and immunity 1990;58(12):3899-902.
1990: KT Miyasaki; A L Bodeau; Michael Selsted; Tomas Ganz; Robert I Lehrer
Killing of oral, gram-negative, facultative bacteria by the rabbit defensin, NP-1.
Oral microbiology and immunology 1990;5(6):315-9.
1990: Tomas Ganz; Michael Selsted; Robert I Lehrer
Defensins.
European journal of haematology 1990;44(1):1-8.
1990: Bruce L Kagan; Michael Selsted; Tomas Ganz; Robert I Lehrer
Antimicrobial defensin peptides form voltage-dependent ion-permeable channels in planar lipid bilayer membranes.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(1):210-4.
1989: Mary Territo; Tomas Ganz; Michael Selsted; Robert I Lehrer
Monocyte-chemotactic activity of defensins from human neutrophils.
The Journal of clinical investigation 1989;84(6):2017-20.
1989: Robert I Lehrer; A Barton; K A Daher; S S Harwig; Tomas Ganz; Michael Selsted
Interaction of human defensins with Escherichia coli. Mechanism of bactericidal activity.
The Journal of clinical investigation 1989;84(2):553-61.
1989: P B Eisenhauer; S S Harwig; D Szklarek; Tomas Ganz; Michael Selsted; Robert I Lehrer
Purification and antimicrobial properties of three defensins from rat neutrophils.
Infection and immunity 1989;57(7):2021-7.
1989: Robert I Lehrer; D Szklarek; A Barton; Tomas Ganz; Kimm Hamann; G J Gleich
Antibacterial properties of eosinophil major basic protein and eosinophil cationic protein.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(12):4428-34.
1988: K A Daher; Robert I Lehrer; Tomas Ganz; Mitchell Kronenberg
Isolation and characterization of human defensin cDNA clones.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(19):7327-31.
1988: Tomas Ganz; J A Metcalf; John Gallin; Laurence A Boxer; Robert I Lehrer
Microbicidal/cytotoxic proteins of neutrophils are deficient in two disorders: Chediak-Higashi syndrome and "specific" granule deficiency.
The Journal of clinical investigation 1988;82(2):552-6.
1988: Robert I Lehrer; Tomas Ganz; Michael Selsted; B M Babior; J T Curnutte
Neutrophils and host defense.
Annals of internal medicine 1988;109(2):127-42.
1988: Robert I Lehrer; Tomas Ganz; D Szklarek; Michael Selsted
Modulation of the in vitro candidacidal activity of human neutrophil defensins by target cell metabolism and divalent cations.
The Journal of clinical investigation 1988;81(6):1829-35.
1988: Robert I Lehrer; A Barton; Tomas Ganz
Concurrent assessment of inner and outer membrane permeabilization and bacteriolysis in E. coli by multiple-wavelength spectrophotometry.
Journal of immunological methods 1988;108(1-2):153-8.
1988: Robert I Lehrer; Tomas Ganz; Michael Selsted
Oxygen-independent bactericidal systems. Mechanisms and disorders.
Hematology/oncology clinics of North America 1988;2(1):159-69.
1986: K A Daher; Michael Selsted; Robert I Lehrer
Direct inactivation of viruses by human granulocyte defensins.
Journal of virology 1986;60(3):1068-74.
1986: Robert I Lehrer; D Szklarek; Tomas Ganz; Michael Selsted
Synergistic activity of rabbit granulocyte peptides against Candida albicans.
Infection and immunity 1986;52(3):902-4.
1986: Tomas Ganz; Michael Selsted; Robert I Lehrer
Antimicrobial activity of phagocyte granule proteins.
Seminars in respiratory infections 1986;1(2):107-17.
1985: Tomas Ganz; Michael Selsted; D Szklarek; S S Harwig; K Daher; D F Bainton; Robert I Lehrer
Defensins. Natural peptide antibiotics of human neutrophils.
The Journal of clinical investigation 1985;76(4):1427-35.
1985: Robert I Lehrer; D Szklarek; Tomas Ganz; Michael Selsted
Correlation of binding of rabbit granulocyte peptides to Candida albicans with candidacidal activity.
Infection and immunity 1985;49(1):207-11.
1985: Michael Selsted; D Szklarek; Tomas Ganz; Robert I Lehrer
Activity of rabbit leukocyte peptides against Candida albicans.
Infection and immunity 1985;49(1):202-6.
1985: Robert I Lehrer; K Daher; Tomas Ganz; Michael Selsted
Direct inactivation of viruses by MCP-1 and MCP-2, natural peptide antibiotics from rabbit leukocytes.
Journal of virology 1985;54(2):467-72.
1984: Michael Selsted; D Szklarek; Robert I Lehrer
Purification and antibacterial activity of antimicrobial peptides of rabbit granulocytes.
Infection and immunity 1984;45(1):150-4.
1983: Robert I Lehrer; Michael Selsted; D Szklarek; J Fleischmann
Antibacterial activity of microbicidal cationic proteins 1 and 2, natural peptide antibiotics of rabbit lung macrophages.
Infection and immunity 1983;42(1):10-4.
1981: Robert I Lehrer; D Szklarek; Michael Selsted; J Fleischmann
Increased content of microbicidal cationic peptides in rabbit alveolar macrophages elicited by complete Freund adjuvant.
Infection and immunity 1981;33(3):775-8.