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Rudolph Leibel

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Y Ravussin; R Gutman; C A LeDuc; Rudolph L Leibel
Estimating energy expenditure in mice using an energy balance technique.
Lixia Gan; Kaiying Guo; Rudolph L Leibel; Timothy E McGraw; Maria Laura Cremona; Yiying Zhang
TNF-α up-regulates protein level and cell surface expression of the leptin receptor by stimulating its export via a PKC-dependent mechanism.
Norman Simpson; Jonathan Javitch; Rudolph L Leibel; Antonella Maffei; Steven Burroughs; Matthew Freeby; Zachary Freyberg; Paul E Harris
Dopamine-mediated autocrine inhibitory circuit regulating human insulin secretion in vitro.

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All Publications

2013: Y Ravussin; R Gutman; C A LeDuc; Rudolph L Leibel
Estimating energy expenditure in mice using an energy balance technique.
International journal of obesity (2005) 2013;37(3):399-403.
2012: Lixia Gan; Kaiying Guo; Rudolph L Leibel; Timothy E McGraw; Maria Laura Cremona; Yiying Zhang
TNF-α up-regulates protein level and cell surface expression of the leptin receptor by stimulating its export via a PKC-dependent mechanism.
Endocrinology 2012;153(12):5821-33.
2012: Norman Simpson; Jonathan Javitch; Rudolph L Leibel; Antonella Maffei; Steven Burroughs; Matthew Freeby; Zachary Freyberg; Paul E Harris
Dopamine-mediated autocrine inhibitory circuit regulating human insulin secretion in vitro.
Molecular endocrinology (Baltimore, Md.) 2012;26(10):1757-72.
2012: Yann Ravussin; Kazuhisa Watanabe; Charles A LeDuc; Rudolph L Leibel
Effects of ambient temperature on adaptive thermogenesis during maintenance of reduced body weight in mice.
American journal of physiology. Regulatory, integrative and comparative physiology 2012;303(4):R438-48.
2012: David A Albert; Pamela Allweiss; Dana T Graves; William C Knowler; Carol Kunzel; Ira B Lamster; Rudolph L Leibel; Karen F Novak; Thomas Oates; Panos N Papapanou; Ann Marie Schmidt; George W Taylor; Angela Ward; Evanthia Lalla
Diabetes and oral disease: implications for health professionals.
Annals of the New York Academy of Sciences 2012;1255():1-15.
2012: Yann Ravussin; Ayme Spor; Jesse Stombaugh; Ruth E Ley; Roee Gutman; Rob Knight; Omry Koren; Charles LeDuc; Rudolph L Leibel
Responses of gut microbiota to diet composition and weight loss in lean and obese mice.
Obesity (Silver Spring, Md.) 2012;20(4):738-47.
2012: Martin G Myers Jr; Matthias H Tschöp; Carol Haft; Steven B Heymsfield; Barbara B Kahn; Maren R. Laughlin; Rudolph L Leibel; Jack A Yanovski
Challenges and opportunities of defining clinical leptin resistance.
Cell metabolism 2012;15(2):150-6.
2012: Harry R Kissileff; Rudolph L Leibel; Laurel S Mayer; Katherine Pavlovich; John C Thornton; Migdalia I Torres; Vamsi Kalari; Michael Rosenbaum
Leptin reverses declines in satiation in weight-reduced obese humans.
The American journal of clinical nutrition 2012;95(2):309-17.
2012: Michael Rosenbaum; Rudolph L Leibel
Brain reorganization following weight loss.
Nestlé Nutrition Institute workshop series 2012;73():1-20.
2011: Kenneth M Baldwin; Dympna Gallagher; Rochelle L Goldsmith; Fadia Haddad; Denis R Joanisse; Rudolph L Leibel; Katherine H Pavlovich; Elisabeth L Shamoon; Michael Rosenbaum
Effects of weight loss and leptin on skeletal muscle in human subjects.
American journal of physiology. Regulatory, integrative and comparative physiology 2011;301(5):R1259-66.
2011: Scott Noggle; Kiboong Oum; Daniel Paull; Robert Prosser; Kathleen Crumm Satriani; Mark V Sauer; Kun Zhang; Matthew Freeby; Ho-Lim Fung; Robin Goland; Athurva Gore; Ellen Greenberg; Rudolph L Leibel; Hector Martinez; Sarah Druckenmiller; Dieter Egli
Human oocytes reprogram somatic cells to a pluripotent state.
Nature 2011;478(7367):70-5.
2011: Dieter Egli; Robin Goland; Karin Katz; Rudolph L Leibel; Douglas A Melton; Douglas Powers; Genevieve Saphier; Michael Alper; Brian Berger; Alice E Chen; Kevin Eggan
Impracticality of egg donor recruitment in the absence of compensation.
Cell stem cell 2011;9(4):293-4.
2011: Lori M Zeltser; Rudolph L Leibel
Roles of the placenta in fetal brain development.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(38):15667-8.
2011: Rushika Conroy; Monica Girotra; Rudolph L Leibel; Donald J McMahon; Katherine H Pavlovich; Michael Rosenbaum; Elizabeth Shane; Judith Korner
Leptin administration does not prevent the bone mineral metabolism changes induced by weight loss.
Metabolism: clinical and experimental 2011;60(9):1222-6.
2011: Y Ravussin; Michael Rosenbaum; B Sarman; Marya Shanabrough; E Borok; Sabrina Diano; R Gutman; Tamas L Horvath; C A LeDuc; A Lehmann; Rudolph L Leibel
Effects of chronic weight perturbation on energy homeostasis and brain structure in mice.
American journal of physiology. Regulatory, integrative and comparative physiology 2011;300(6):R1352-62.
2011: John D Overton; Rudolph L Leibel
Mahoganoid and mahogany mutations rectify the obesity of the yellow mouse by effects on endosomal traffic of MC4R protein.
The Journal of biological chemistry 2011;286(21):18914-29.
2011: Priya Duggal; Xiaoti Guo; Rashidul Haque; Kristine M Peterson; Stacy Ricklefs; Dinesh Mondal; Faisal Alam; Zannatun Noor; Hans P Verkerke; Chelsea Marie; Charles A Leduc; Streamson C Chua; Martin G Myers; Rudolph L Leibel; Eric Houpt; Carol A Gilchrist; Alan Sher; Stephen F Porcella; William A Petri
A mutation in the leptin receptor is associated with Entamoeba histolytica infection in children.
The Journal of clinical investigation 2011;121(3):1191-8.
2011: Jill S Carmody; Phyllis Wan-Huen; Domenico Accili; Lori M Zeltser; Rudolph L Leibel
Respective contributions of maternal insulin resistance and diet to metabolic and hypothalamic phenotypes of progeny.
Obesity (Silver Spring, Md.) 2011;19(3):492-9.
2011: George Stratigopoulos; Charles A LeDuc; Maria Laura Cremona; Wendy Chung; Rudolph L Leibel
Cut-like homeobox 1 (CUX1) regulates expression of the fat mass and obesity-associated and retinitis pigmentosa GTPase regulator-interacting protein-1-like (RPGRIP1L) genes and coordinates leptin receptor signaling.
The Journal of biological chemistry 2011;286(3):2155-70.
2011: Hemant K Tiwari; David B Allison; Rudolph L Leibel; Jeffrey Lieberman; Amit Patki; T Scott Stroup; Wendy K Chung
Association of Allelic Variation in Genes Mediating Aspects of Energy Homeostasis with Weight Gain during Administration of Antipsychotic Drugs (CATIE Study).
Frontiers in genetics 2011;2():56.
2011: Dieter Egli; Claire Fitzgerald; Kathryn J Go; Robin Goland; Justin Ichida; William G Kearns; Rudolph L Leibel; Douglas A Melton; Jay Patel; Genevieve Saphier; Nicole Acevedo; Manfred Baetscher; Alice E Chen; Kevin Eggan
Reprogramming within hours following nuclear transfer into mouse but not human zygotes.
Nature communications 2011;2():488.
2010: George Stratigopoulos; Rudolph L Leibel
FTO gains function.
Nature genetics 2010;42(12):1038-9.
2010: Martin G Myers Jr; Rudolph L Leibel; Randy J Seeley; Michael W Schwartz
Obesity and leptin resistance: distinguishing cause from effect.
Trends in endocrinology and metabolism: TEM 2010;21(11):643-51.
2010: Michael Rosenbaum; Rudolph L Leibel
Adaptive thermogenesis in humans.
International journal of obesity (2005) 2010;34 Suppl 1():S47-55.
2010: Michael Rosenbaum; Harry R Kissileff; Laurel E S Mayer; Joy Hirsch; Rudolph L Leibel
Energy intake in weight-reduced humans.
Brain research 2010;1350():95-102.
2010: E L Kinnally; J P Capitanio; Rudolph L Leibel; L Deng; C LeDuc; faride haghighi; J John Mann
Epigenetic regulation of serotonin transporter expression and behavior in infant rhesus macaques.
Genes, brain, and behavior 2010;9(6):575-82.
2010: Norann Zaghloul; Yangjian Liu; Jantje M Gerdes; Cecilia Gascue; Edwin C Oh; Carmen C Leitch; Yana Bromberg; Jonathan Binkley; Rudolph L Leibel; Arend Sidow; Jose L Badano; Nicholas Katsanis
Functional analyses of variants reveal a significant role for dominant negative and common alleles in oligogenic Bardet-Biedl syndrome.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(23):10602-7.
2010: Rochelle Goldsmith; Denis R Joanisse; Dympna Gallagher; Katherine Pavlovich; Elisabeth Shamoon; Rudolph L Leibel; Michael Rosenbaum
Effects of experimental weight perturbation on skeletal muscle work efficiency, fuel utilization, and biochemistry in human subjects.
American journal of physiology. Regulatory, integrative and comparative physiology 2010;298(1):R79-88.
2009: Rene Maehr; Shuibing Chen; Melinda Snitow; Thomas Ludwig; Lisa Yagasaki; Robin Goland; Rudolph L Leibel; Douglas A Melton
Generation of pluripotent stem cells from patients with type 1 diabetes.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(37):15768-73.
2009: Yana Bromberg; John Overton; Christian Vaisse; Rudolph L Leibel; Burkhard Rost
In silico mutagenesis: a case study of the melanocortin 4 receptor.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(9):3059-69.
2009: Robin Goland; Matthew Freeby; Ramin Parsey; Yoshifumi Saisho; Dileep Kumar; Norman Simpson; Joy Hirsch; Martin R Prince; Antonella Maffei; J John Mann; Peter C Butler; Ronald Van Heertum; Rudolph L Leibel; Masanori Ichise; Paul E Harris
11C-dihydrotetrabenazine PET of the pancreas in subjects with long-standing type 1 diabetes and in healthy controls.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2009;50(3):382-9.
2009: Wendy Chung; Minyoung Shin; Thomas C Jaramillo; Rudolph L Leibel; Charles A LeDuc; SG Fischer; Efthia Tzilianos; Ayman A Gheith; Alan S Lewis; Dane M Chetkovich
Absence epilepsy in apathetic, a spontaneous mutant mouse lacking the h channel subunit, HCN2.
Neurobiology of disease 2009;33(3):499-508.
2009: Wendy Chung; Amit Patki; Naoki Matsuoka; Bert Boyer; Nianjun Liu; Solomon K Musani; Anna V Goropashnaya; Perciliz L Tan; Nicholas Katsanis; Stephen B Johnson; Peter K Gregersen; David Allison; Rudolph L Leibel; Hemant K Tiwari
Analysis of 30 genes (355 SNPS) related to energy homeostasis for association with adiposity in European-American and Yup'ik Eskimo populations.
Human heredity 2009;67(3):193-205.
2008: Rudolph L Leibel
Molecular physiology of weight regulation in mice and humans.
International journal of obesity (2005) 2008;32 Suppl 7():S98-108.
2008: Wendy Chung; Rudolph L Leibel
Considerations regarding the genetics of obesity.
Obesity (Silver Spring, Md.) 2008;16 Suppl 3():S33-9.
2008: Michael Rosenbaum; Jules Hirsch; Dympna A Gallagher; Rudolph L Leibel
Long-term persistence of adaptive thermogenesis in subjects who have maintained a reduced body weight.
The American journal of clinical nutrition 2008;88(4):906-12.
2008: Anthony Raffo; Kolbe Hancock; Teresa Polito; Yuli Xie; Gordon Andan; Piotr Witkowski; Mark Hardy; Pasquale Barba; Caterina Ferrara; Antonella Maffei; Matthew Freeby; Robin Goland; Rudolph L Leibel; Ian R Sweet; Paul E Harris
Role of vesicular monoamine transporter type 2 in rodent insulin secretion and glucose metabolism revealed by its specific antagonist tetrabenazine.
The Journal of endocrinology 2008;198(1):41-9.
2008: Michael Rosenbaum; Melissa Sy; Katherine Pavlovich; Rudolph L Leibel; Joy Hirsch
Leptin reverses weight loss-induced changes in regional neural activity responses to visual food stimuli.
The Journal of clinical investigation 2008;118(7):2583-91.
2008: Ruth B S Harris; Rudolph L Leibel
Location, location, location...
Cell metabolism 2008;7(5):359-61.
2008: George Stratigopoulos; Stephanie L Padilla; Charles A LeDuc; Elizabeth Watson; Andrew T Hattersley; Mark I McCarthy; Lori M Zeltser; Wendy Chung; Rudolph L Leibel
Regulation of Fto/Ftm gene expression in mice and humans.
American journal of physiology. Regulatory, integrative and comparative physiology 2008;294(4):R1185-96.
2008: Rajan Murthy; Paul Harris; Norman Simpson; Ronald L Van Heertum; Rudolph L Leibel; J John Mann; Ramin V Parsey
Whole body [11C]-dihydrotetrabenazine imaging of baboons: biodistribution and human radiation dosimetry estimates.
European journal of nuclear medicine and molecular imaging 2008;35(4):790-7.
2008: Marija Dokmanovic-Chouinard; Wendy Chung; Jean-Claude Chevre; Elizabeth Watson; Jason Yonan; Beebe Wiegand; Yana Bromberg; Nao Wakae; Chris V Wright; John Overton; Sujoy Ghosh; Ganesh M Sathe; Carina E Ammala; Kathleen K Brown; Rokuro Ito; Charles LeDuc; Keely Solomon; SG Fischer; Rudolph L Leibel
Positional cloning of "Lisch-Like", a candidate modifier of susceptibility to type 2 diabetes in mice.
PLoS genetics 2008;4(7):e1000137.
2008: Stuart P Weisberg; Rudolph L Leibel
An apparent role for Alox15 in the pathogenesis of diabetes in the NOD mouse: parsing the supporting genetic data.
Diabetes 2008;57(1):1-2.
2007: Samuel Klein; David Allison; Steven B Heymsfield; David E Kelley; Rudolph L Leibel; Cathy Nonas; Richard Kahn
Waist circumference and cardiometabolic risk: a consensus statement from shaping America's health: Association for Weight Management and Obesity Prevention; NAASO, the Obesity Society; the American Society for Nutrition; and the American Diabetes Association.
Diabetes care 2007;30(6):1647-52.
2007: Samuel Klein; David Allison; Steven B Heymsfield; David E Kelley; Rudolph L Leibel; Cathy Nonas; Richard Kahn
Waist Circumference and Cardiometabolic Risk: a Consensus Statement from Shaping America's Health: Association for Weight Management and Obesity Prevention; NAASO, the Obesity Society; the American Society for Nutrition; and the American Diabetes Association.
Obesity (Silver Spring, Md.) 2007;15(5):1061-7.
2007: Samuel Klein; David Allison; Steven B Heymsfield; David E Kelley; Rudolph L Leibel; Cathy Nonas; Richard Kahn
Waist circumference and cardiometabolic risk: a consensus statement from Shaping America's Health: Association for Weight Management and Obesity Prevention; NAASO, The Obesity Society; the American Society for Nutrition; and the American Diabetes Association.
The American journal of clinical nutrition 2007;85(5):1197-202.
2007: Haijun D Sun; Maria Malabunga; James R Tonra; Roberto DiRenzo; Francine E Carrick; Huiyuan Zheng; Hans-Rudolf Berthoud; Owen P McGuinness; Juqun Shen; Peter Bohlen; Rudolph L Leibel; Paul Kussie
Monoclonal antibody antagonists of hypothalamic FGFR1 cause potent but reversible hypophagia and weight loss in rodents and monkeys.
American journal of physiology. Endocrinology and metabolism 2007;292(3):E964-76.
2006: Loan K Phan; Wendy Chung; Rudolph L Leibel
The mahoganoid mutation (Mgrn1md) improves insulin sensitivity in mice with mutations in the melanocortin signaling pathway independently of effects on adiposity.
American journal of physiology. Endocrinology and metabolism 2006;291(3):E611-20.
2006: Fabiola Souza; Norman Simpson; Anthony J Raffo; Chitra Saxena; Antonella Maffei; Mark Hardy; Michael R Kilbourn; Robin Goland; Rudolph L Leibel; J John Mann; Ronald L Van Heertum; Paul E Harris
Longitudinal noninvasive PET-based beta cell mass estimates in a spontaneous diabetes rat model.
The Journal of clinical investigation 2006;116(6):1506-13.
2006: Wendy Chung; Rudolph L Leibel
The links between obesity, leptin, and prostate cancer.
Cancer journal (Sudbury, Mass.) 2006;12(3):178-81.
2006: Rudolph L Leibel
The molecular genetics of the melanocortin pathway and energy homeostasis.
Cell metabolism 2006;3(2):79-81.
2006: Stuart P Weisberg; Deborah Hunter; Reid Huber; Jacob Lemieux; Sarah Slaymaker; Kris Vaddi; Israel F Charo; Rudolph L Leibel; Anthony W Ferrante
CCR2 modulates inflammatory and metabolic effects of high-fat feeding.
The Journal of clinical investigation 2006;116(1):115-24.
2005: Michael Rosenbaum; Rochelle Goldsmith; Daniel M Bloomfield; Anthony R Magnano; Louis Weimer; Steven B Heymsfield; Dympna Gallagher; Laurel Mayer; Ellen Murphy; Rudolph L Leibel
Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight.
The Journal of clinical investigation 2005;115(12):3579-86.
2005: Wendy Chung; Rudolph L Leibel
Molecular physiology of syndromic obesities in humans.
Trends in endocrinology and metabolism: TEM 2005;16(6):267-72.
2005: Laurel Mayer; B Timothy Walsh; Richard N Pierson; Steven B Heymsfield; Dympna Gallagher; Jack Wang; Michael K Parides; Rudolph L Leibel; Michelle P Warren; Erin Killory; Deborah R Glasofer
Body fat redistribution after weight gain in women with anorexia nervosa.
The American journal of clinical nutrition 2005;81(6):1286-91.
2005: Sara Seidelmann; Carl De Luca; Rudolph L Leibel; Jan L Breslow; Alan R Tall; Carrie L Welch
Quantitative trait locus mapping of genetic modifiers of metabolic syndrome and atherosclerosis in low-density lipoprotein receptor-deficient mice: identification of a locus for metabolic syndrome and increased atherosclerosis on chromosome 4.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(1):204-10.
2004: Kai-Ying Guo; Patricia Halo; Rudolph L Leibel; Yiying Zhang
Effects of obesity on the relationship of leptin mRNA expression and adipocyte size in anatomically distinct fat depots in mice.
American journal of physiology. Regulatory, integrative and comparative physiology 2004;287(1):R112-9.
2004: David Matthew Nathan; Rudolph L Leibel
Toward optimal health: the experts discuss advances in diabetes management in women. Interview by Jodi Godfrey.
Journal of women's health (2002) 2004;13(4):365-70.
2003: Stuart P Weisberg; Daniel McCann; Manisha Desai; Michael Rosenbaum; Rudolph L Leibel; Anthony W Ferrante
Obesity is associated with macrophage accumulation in adipose tissue.
The Journal of clinical investigation 2003;112(12):1796-808.
2003: Judith Korner; Rudolph L Leibel
To eat or not to eat - how the gut talks to the brain.
The New England journal of medicine 2003;349(10):926-8.
2003: Michael P Wajnrajch; Joseph M Gertner; Alisa S Sokoloff; Irina Ten; Madeleine D Harbison; Irène Netchine; Hiralal G Maheshwari; David B Goldstein; Serge Amselem; Gerhard Baumann; Rudolph L Leibel
Haplotype analysis of the growth hormone releasing hormone receptor locus in three apparently unrelated kindreds from the indian subcontinent with the identical mutation in the GHRH receptor.
American journal of medical genetics. Part A 2003;120A(1):77-83.
2003: Michael Rosenbaum; Krista Vandenborne; Rochelle Goldsmith; Jean-Aime Simoneau; Steven B Heymsfield; Denis R Joanisse; Jules Hirsch; Ellen Murphy; Dwight Matthews; Karen segal; Rudolph L Leibel
Effects of experimental weight perturbation on skeletal muscle work efficiency in human subjects.
American journal of physiology. Regulatory, integrative and comparative physiology 2003;285(1):R183-92.
2003: Michael W Schwartz; Stephen C Woods; Randy J Seeley; Gregory S Barsh; Denis Baskin; Rudolph L Leibel
Is the energy homeostasis system inherently biased toward weight gain?
Diabetes 2003;52(2):232-8.
2002: Walter C Willett; Rudolph L Leibel
Dietary fat is not a major determinant of body fat.
The American journal of medicine 2002;113 Suppl 9B():47S-59S.
2002: Michael Boschmann; Michael Rosenbaum; Rudolph L Leibel; Karen segal
Metabolic and hemodynamic responses to exercise in subcutaneous adipose tissue and skeletal muscle.
International journal of sports medicine 2002;23(8):537-43.
2002: Loan K Phan; Feng Lin; Charles A LeDuc; Wendy Chung; Rudolph L Leibel
The mouse mahoganoid coat color mutation disrupts a novel C3HC4 RING domain protein.
The Journal of clinical investigation 2002;110(10):1449-59.
2002: Rudolph L Leibel
The role of leptin in the control of body weight.
Nutrition reviews 2002;60(10 Pt 2):S15-9; discussion S68-84, 85-7.
2002: Yong-Chuan Tao; Rudolph L Leibel
Identifying functional relationships among human genes by systematic analysis of biological literature.
BMC bioinformatics 2002;3():16.
2002: Moonseong Heo; Rudolph L Leibel; Kevin R Fontaine; Bert Boyer; Wendy Chung; Markku Koulu; Matti K Karvonen; Ullamari Pesonen; Aila Rissanen; M Laakso; M I J Uusitupa; Y Chagnon; C Bouchard; Patricia A Donohoue; T L Burns; Alan R Shuldiner; Kristi D Silver; Ross E Andersen; O Pedersen; Søren M Echwald; Thorkild I A Sørensen; PS Behn; M A Permutt; K B Jacobs; R C Elston; D J Hoffman; E Gropp; David Allison
A meta-analytic investigation of linkage and association of common leptin receptor (LEPR) polymorphisms with body mass index and waist circumference.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2002;26(5):640-6.
2002: Michael Rosenbaum; Ellen M Murphy; Steven B Heymsfield; Dwight E Matthews; Rudolph L Leibel
Low dose leptin administration reverses effects of sustained weight-reduction on energy expenditure and circulating concentrations of thyroid hormones.
The Journal of clinical endocrinology and metabolism 2002;87(5):2391-4.
2002: Yiying Zhang; Kai-Ying Guo; Patricia A Diaz; Moonseong Heo; Rudolph L Leibel
Determinants of leptin gene expression in fat depots of lean mice.
American journal of physiology. Regulatory, integrative and comparative physiology 2002;282(1):R226-34.
2001: Judith Korner; Eriika Savontaus; Streamson Chua Jr.; Rudolph L Leibel; Sharon L Wardlaw
Leptin regulation of Agrp and Npy mRNA in the rat hypothalamus.
Journal of neuroendocrinology 2001;13(11):959-66.
2001: Moonseong Heo; Rudolph L Leibel; Bert Boyer; Wendy Chung; Markku Koulu; Matti K Karvonen; Ullamari Pesonen; Aila Rissanen; M Laakso; M I J Uusitupa; Y Chagnon; C Bouchard; Patricia A Donohoue; T L Burns; Alan R Shuldiner; Kristi D Silver; Ross E Andersen; O Pedersen; Søren M Echwald; Thorkild I A Sørensen; PS Behn; M A Permutt; K B Jacobs; R C Elston; D J Hoffman; David Allison
Pooling analysis of genetic data: the association of leptin receptor (LEPR) polymorphisms with variables related to human adiposity.
Genetics 2001;159(3):1163-78.
2001: A W Ferrante; Marie Thearle; T Liao; Rudolph L Leibel
Effects of leptin deficiency and short-term repletion on hepatic gene expression in genetically obese mice.
Diabetes 2001;50(10):2268-78.
2001: Michael Rosenbaum; Angelo Pietrobelli; Joseph R Vasselli; Steven B Heymsfield; Rudolph L Leibel
Sexual dimorphism in circulating leptin concentrations is not accounted for by differences in adipose tissue distribution.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2001;25(9):1365-71.
2001: Carol N Boozer; Rudolph L Leibel; R J Love; MC Cha; Louis J Aronne
Synergy of sibutramine and low-dose leptin in treatment of diet-induced obesity in rats.
Metabolism: clinical and experimental 2001;50(8):889-93.
2001: Timothy J Kowalski; Shun Mei Liu; Rudolph L Leibel; Streamson Chua Jr.
Transgenic complementation of leptin-receptor deficiency. I. Rescue of the obesity/diabetes phenotype of LEPR-null mice expressing a LEPR-B transgene.
Diabetes 2001;50(2):425-35.
2001: Yiying Zhang; C Hufnagel; Sandra Eiden; Kai-Ying Guo; P A Diaz; Rudolph L Leibel; Ingrid Schmidt
Mechanisms for LEPR-mediated regulation of leptin expression in brown and white adipocytes in rat pups.
Physiological genomics 2001;4(3):189-99.
2000: M B Horlick; Michael Rosenbaum; M Nicolson; Lenore S Levine; Barbara Fedun; Jack Wang; Richard N Pierson; Rudolph L Leibel
Effect of puberty on the relationship between circulating leptin and body composition.
The Journal of clinical endocrinology and metabolism 2000;85(7):2509-18.
2000: Judith Korner; Sharon L Wardlaw; Shun Mei Liu; Irene M Conwell; Rudolph L Leibel; Streamson Chua Jr.
Effects of leptin receptor mutation on Agrp gene expression in fed and fasted lean and obese (LA/N-faf) rats.
Endocrinology 2000;141(7):2465-71.
2000: M Rosenbaum; J Hirsch; E Murphy; Rudolph L Leibel
Effects of changes in body weight on carbohydrate metabolism, catecholamine excretion, and thyroid function.
The American journal of clinical nutrition 2000;71(6):1421-32.
2000: MS Lee; Michael P Wajnrajch; S S Kim; Leslie P Plotnick; J Wang; Joseph M Gertner; Rudolph L Leibel; Priscilla S Dannies
Autosomal dominant growth hormone (GH) deficiency type II: the Del32-71-GH deletion mutant suppresses secretion of wild-type GH.
Endocrinology 2000;141(3):883-90.
1999: Judith Korner; Streamson Chua Jr.; J A Williams; Rudolph L Leibel; Sharon L Wardlaw
Regulation of hypothalamic proopiomelanocortin by leptin in lean and obese rats.
Neuroendocrinology 1999;70(6):377-83.
1999: S Wu-Peng; M Rosenbaum; M Nicolson; Streamson Chua Jr.; Rudolph L Leibel
Effects of exogenous gonadal steroids on leptin homeostasis in rats.
Obesity research 1999;7(6):586-92.
1999: C Hufnagel; Sandra Eiden; Barbara Nuesslein-Hildesheim; Yiying Zhang; Rudolph L Leibel; Ingrid Schmidt
Mutation in the leptin receptor (Leprfa) causes fat-storage-independent hyperleptinaemia in neonatal rats.
Pflügers Archiv : European journal of physiology 1999;438(4):570-2.
1999: Wendy Chung; Amy Luke; Richard S Cooper; C Rotini; Antonio Vidal-Puig; Michael Rosenbaum; M Chua; Gemma Solanes; M Zheng; L Zhao; C LeDuc; A Eisberg; F Chu; Ellen Murphy; M Schreier; Louis J Aronne; S Caprio; B Kahle; D Gordon; S M Leal; Rochelle Goldsmith; A L Andreu; C Bruno; S DiMauro; Rudolph L Leibel
Genetic and physiologic analysis of the role of uncoupling protein 3 in human energy homeostasis.
Diabetes 1999;48(9):1890-5.
1999: Wendy Chung; Amy Luke; Richard S Cooper; C Rotini; Antonio Vidal-Puig; Michael Rosenbaum; D Gordon; S M Leal; S Caprio; Rochelle Goldsmith; A L Andreu; C Bruno; S DiMauro; Moonseong Heo; WL Lowe; B B Lowell; David Allison; Rudolph L Leibel
The long isoform uncoupling protein-3 (UCP3L) in human energy homeostasis.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1999;23 Suppl 6():S49-50.
1999: Michael Boschmann; Michael Rosenbaum; Rudolph L Leibel; Karen segal
[Physical activity exhibits differences in the action of fat metabolism in men and women--results of a microdialysis study].
Forschende Komplementärmedizin 1999;6(1):52-3.
1998: Shun Mei Liu; Rudolph L Leibel; Streamson Chua Jr.
Partial duplication in the leprdb-Pas mutation is a result of unequal crossing over.
Mammalian genome : official journal of the International Mammalian Genome Society 1998;9(9):780-1.
1998: William I Sivitz; S Walsh; D Morgan; Patricia A Donohoue; William G Haynes; Rudolph L Leibel
Plasma leptin in diabetic and insulin-treated diabetic and normal rats.
Metabolism: clinical and experimental 1998;47(5):584-91.
1998: M Rosenbaum; Rudolph L Leibel
Leptin: a molecule integrating somatic energy stores, energy expenditure and fertility.
Trends in endocrinology and metabolism: TEM 1998;9(3):117-24.
1998: Wendy Chung; K Belfi; M Chua; J Wiley; RM Mackintosh; M Nicolson; Carol N Boozer; Rudolph L Leibel
Heterozygosity for Lep(ob) or Lep(rdb) affects body composition and leptin homeostasis in adult mice.
The American journal of physiology 1998;274(4 Pt 2):R985-90.
1998: J Hirsch; Rudolph L Leibel
The genetics of obesity.
Hospital practice (1995) 1998;33(3):55-9, 62-5, 69-70 passim.
1998: J Hirsch; Lisa Cooper Hudgins; Rudolph L Leibel; M Rosenbaum
Diet composition and energy balance in humans.
The American journal of clinical nutrition 1998;67(3 Suppl):551S-555S.
1997: Rudolph L Leibel; Wendy Chung; Streamson Chua Jr.
The molecular genetics of rodent single gene obesities.
The Journal of biological chemistry 1997;272(51):31937-40.
1997: Yiying Zhang; M Olbort; K Schwarzer; Barbara Nuesslein-Hildesheim; M Nicolson; E Murphy; Timothy J Kowalski; Ingrid Schmidt; Rudolph L Leibel
The leptin receptor mediates apparent autocrine regulation of leptin gene expression.
Biochemical and biophysical research communications 1997;240(2):492-5.
1997: Michael Rosenbaum; M Nicolson; J Hirsch; E Murphy; F Chu; Rudolph L Leibel
Effects of weight change on plasma leptin concentrations and energy expenditure.
The Journal of clinical endocrinology and metabolism 1997;82(11):3647-54.
1997: Kristi D Silver; Jeremy Walston; Wendy Chung; F Yao; V V Parikh; R Andersen; Lawrence J Cheskin; Dariush Elahi; D Muller; Rudolph L Leibel; Alan R Shuldiner
The Gln223Arg and Lys656Asn polymorphisms in the human leptin receptor do not associate with traits related to obesity.
Diabetes 1997;46(11):1898-900.
1997: Streamson Chua Jr.; Ioannis Koutras; L Han; Shun Mei Liu; J Kay; S J Young; Wendy Chung; Rudolph L Leibel
Fine structure of the murine leptin receptor gene: splice site suppression is required to form two alternatively spliced transcripts.
Genomics 1997;45(2):264-70.
1997: E B Kahle; Rudolph L Leibel; D W Domaschko; S G Raney; K T Mann
Obesity genes and insulin resistance syndrome.
Annals of the New York Academy of Sciences 1997;827():35-49.
1997: Wendy Chung; L Power-Kehoe; M Chua; F Chu; Louis J Aronne; Z Huma; Melinda S Sothern; John N Udall; B Kahle; Rudolph L Leibel
Exonic and intronic sequence variation in the human leptin receptor gene (LEPR).
Diabetes 1997;46(9):1509-11.
1997: M Rosenbaum; Rudolph L Leibel; J Hirsch
Obesity.
The New England journal of medicine 1997;337(6):396-407.
1997: L J Arrone; RM Mackintosh; M Rosenbaum; Rudolph L Leibel; J Hirsch
Cardiac autonomic nervous system activity in obese and never-obese young men.
Obesity research 1997;5(4):354-9.
1997: Jeanine B Albu; David Allison; Carol N Boozer; Steven B Heymsfield; Harry R Kissileff; A Kretser; K Krumhar; Rudolph L Leibel; C Nonas; Xavier Pi-Sunyer; Theodore B Vanitallie; E Wedral
Obesity solutions: report of a meeting.
Nutrition reviews 1997;55(5):150-6.
1997: Wendy Chung; Streamson Chua Jr.; G H Lee; Rudolph L Leibel
Polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP) and electrophoretic assays for the mouse obese (Lepob) mutation.
Obesity research 1997;5(3):183-5.
1997: Wendy Chung; M Zheng; M Chua; E Kershaw; L Power-Kehoe; M Tsuji; XS Wu-Peng; J Williams; Streamson Chua Jr.; Rudolph L Leibel
Genetic modifiers of Leprfa associated with variability in insulin production and susceptibility to NIDDM.
Genomics 1997;41(3):332-44.
1997: XS Wu-Peng; Streamson Chua Jr.; N Okada; Shun Mei Liu; M Nicolson; Rudolph L Leibel
Phenotype of the obese Koletsky (f) rat due to Tyr763Stop mutation in the extracellular domain of the leptin receptor (Lepr): evidence for deficient plasma-to-CSF transport of leptin in both the Zucker and Koletsky obese rat.
Diabetes 1997;46(3):513-8.
1996: Wendy Chung; L Power-Kehoe; M Chua; R Lee; Rudolph L Leibel
Genomic structure of the human OB receptor and identification of two novel intronic microsatellites.
Genome research 1996;6(12):1192-9.
1996: Michael Rosenbaum; M Nicolson; J Hirsch; S B Heymsfield; D Gallagher; F Chu; Rudolph L Leibel
Effects of gender, body composition, and menopause on plasma concentrations of leptin.
The Journal of clinical endocrinology and metabolism 1996;81(9):3424-7.
1996: RA Norman; Rudolph L Leibel; Wendy Chung; L Power-Kehoe; Streamson Chua Jr.; William C Knowler; DB Thompson; Clifton Bogardus; Eric Ravussin
Absence of linkage of obesity and energy metabolism to markers flanking homologues of rodent obesity genes in Pima Indians.
Diabetes 1996;45(9):1229-32.
1996: Streamson Chua Jr.; DW White; XS Wu-Peng; Shun Mei Liu; N Okada; E E Kershaw; Wendy Chung; L Power-Kehoe; M Chua; Louis A Tartaglia; Rudolph L Leibel
Phenotype of fatty due to Gln269Pro mutation in the leptin receptor (Lepr).
Diabetes 1996;45(8):1141-3.
1996: Wendy Chung; L Power-Kehoe; M Chua; Rudolph L Leibel
Mapping of the OB receptor to 1p in a region of nonconserved gene order from mouse and rat to human.
Genome research 1996;6(5):431-8.
1996: B Meierfrankenfeld; M Abelenda; H Jauker; Martin Klingenspor; E E Kershaw; Streamson Chua Jr.; Rudolph L Leibel; Ingrid Schmidt
Perinatal energy stores and excessive fat deposition in genetically obese (fa/fa) rats.
The American journal of physiology 1996;270(4 Pt 1):E700-8.
1996: Wendy Chung; J Goldberg-Berman; L Power-Kehoe; Rudolph L Leibel
Molecular mapping of the tubby (tub) mutation on mouse chromosome 7.
Genomics 1996;32(2):210-7.
1996: M Rosenbaum; Eric Ravussin; D E Matthews; C Gilker; R Ferraro; S B Heymsfield; J Hirsch; Rudolph L Leibel
A comparative study of different means of assessing long-term energy expenditure in humans.
The American journal of physiology 1996;270(3 Pt 2):R496-504.
1996: Streamson Chua Jr.; Wendy Chung; XS Wu-Peng; Y Zhang; Shun Mei Liu; Louis A Tartaglia; Rudolph L Leibel
Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor.
Science (New York, N.Y.) 1996;271(5251):994-6.
1996: M P Wajnrajch; J M Gertner; M D Harbison; Streamson Chua Jr.; Rudolph L Leibel
Nonsense mutation in the human growth hormone-releasing hormone receptor causes growth failure analogous to the little (lit) mouse.
Nature genetics 1996;12(1):88-90.
1995: Eric Green; M Maffei; V V Braden; R Proenca; U DeSilva; Y Zhang; Streamson Chua Jr.; Rudolph L Leibel; Jean Weissenbach; Jeffrey M Friedman
The human obese (OB) gene: RNA expression pattern and mapping on the physical, cytogenetic, and genetic maps of chromosome 7.
Genome research 1995;5(1):5-12.
1995: L J Arone; R Mackintosh; M Rosenbaum; Rudolph L Leibel; J Hirsch
Autonomic nervous system activity in weight gain and weight loss.
The American journal of physiology 1995;269(1 Pt 2):R222-5.
1995: E E Kershaw; Streamson Chua Jr.; J A Williams; E M Murphy; Rudolph L Leibel
Molecular mapping of SSRs for Pgm1 and C8b in the vicinity of the rat fatty locus.
Genomics 1995;27(1):149-54.
1995: E E Kershaw; Streamson Chua Jr.; Rudolph L Leibel
Localization of a (CA)n repeat in glucagon-like peptide-1 receptor gene (Glp1r) to proximal mouse chromosome 17 and its linkage to other markers.
Mammalian genome : official journal of the International Mammalian Genome Society 1995;6(4):301-3.
1995: G E Truett; H J Jacob; J Miller; G Drouin; N Bahary; J W Smoller; E S Lander; Rudolph L Leibel
Genetic map of rat chromosome 5 including the fatty (fa) locus.
Mammalian genome : official journal of the International Mammalian Genome Society 1995;6(1):25-30.
1994: M P Wajnrajch; Streamson Chua Jr.; Eric Green; Rudolph L Leibel
Human growth hormone-releasing hormone receptor (GHRHR) maps to a YAC at chromosome 7p15.
Mammalian genome : official journal of the International Mammalian Genome Society 1994;5(9):595.
1994: L M Power; Streamson Chua Jr.; Rudolph L Leibel
Locus D1S21 contains exonic sequence from the C8 beta component of complement.
Mammalian genome : official journal of the International Mammalian Genome Society 1994;5(2):125-6.
1993: S K Fried; Rudolph L Leibel; N K Edens; J G Kral
Lipolysis in intraabdominal adipose tissues of obese women and men.
Obesity research 1993;1(6):443-8.
1993: Streamson Chua Jr.; M H Hansen; G E Truett; Rudolph L Leibel
Utility of a C-jun microsatellite marker in determining gene dosage for fatty (fa).
Obesity research 1993;1(6):475-80.
1993: N K Edens; S K Fried; J G Kral; J Hirsch; Rudolph L Leibel
In vitro lipid synthesis in human adipose tissue from three abdominal sites.
The American journal of physiology 1993;265(3 Pt 1):E374-9.
1993: N Bahary; D A Siegel; J Walsh; Y Zhang; L Leopold; Rudolph L Leibel; R Proenca; Jeffrey M Friedman
Microdissection of proximal mouse chromosome 6: identification of RFLPs tightly linked to the ob mutation.
Mammalian genome : official journal of the International Mammalian Genome Society 1993;4(9):511-5.
1993: Michael Rosenbaum; C C Malbon; J Hirsch; Rudolph L Leibel
Lack of beta 3-adrenergic effect on lipolysis in human subcutaneous adipose tissue.
The Journal of clinical endocrinology and metabolism 1993;77(2):352-5.
1993: J W Smoller; G E Truett; J Hirsch; Rudolph L Leibel
The Zucker fatty (fa) gene is not a mutation of corticotropin-releasing factor.
The American journal of physiology 1993;264(1 Pt 2):R12-5.
1993: Rudolph L Leibel; N Bahary; Jeffrey M Friedman
Strategies for the molecular genetic analysis of obesity in humans.
Critical reviews in food science and nutrition 1993;33(4-5):351-8.
1993: Streamson Chua Jr.; K Hennessey; P Zeitler; Rudolph L Leibel
The little (lit) mutation cosegregates with the growth hormone releasing factor receptor on mouse chromosome 6.
Mammalian genome : official journal of the International Mammalian Genome Society 1993;4(10):555-9.
1993: J W Smoller; G E Truett; J Hirsch; Rudolph L Leibel
A molecular genetic method for genotyping fatty (fa/fa) rats.
The American journal of physiology 1993;264(1 Pt 2):R8-11.
1992: N Bahary; J E Pachter; R Felman; Rudolph L Leibel; K Albright; S Cram; Jeffrey M Friedman
Molecular mapping of mouse chromosomes 4 and 6: use of a flow-sorted Robertsonian chromosome.
Genomics 1992;13(3):761-9.
1992: Rudolph L Leibel
Fat as fuel and metabolic signal.
Nutrition reviews 1992;50(4 ( Pt 2)):12-6.
1991: J Hirsch; Rudolph L Leibel
Clinical review 28: A biological basis for human obesity.
The Journal of clinical endocrinology and metabolism 1991;73(6):1153-7.
1991: J Hirsch; Rudolph L Leibel; R Mackintosh; A Aguirre
Heart rate variability as a measure of autonomic function during weight change in humans.
The American journal of physiology 1991;261(6 Pt 2):R1418-23.
1991: Jeffrey M Friedman; Rudolph L Leibel; D S Siegel; J Walsh; N Bahary
Molecular mapping of the mouse ob mutation.
Genomics 1991;11(4):1054-62.
1991: J Hirsch; R Mackintosh; Rudolph L Leibel
Nutritionally-induced changes in parasympathetic function.
Brain research bulletin 1991;27(3-4):541-2.
1991: G E Truett; N Bahary; Jeffrey M Friedman; Rudolph L Leibel
Rat obesity gene fatty (fa) maps to chromosome 5: evidence for homology with the mouse gene diabetes (db).
Proceedings of the National Academy of Sciences of the United States of America 1991;88(17):7806-9.
1991: N Bahary; G Zorich; J E Pachter; Rudolph L Leibel; Jeffrey M Friedman
Molecular genetic linkage maps of mouse chromosomes 4 and 6.
Genomics 1991;11(1):33-47.
1991: Michael Rosenbaum; E Presta; J Hirsch; Rudolph L Leibel
Regional differences in adrenoreceptor status of adipose tissue in adults and prepubertal children.
The Journal of clinical endocrinology and metabolism 1991;73(2):341-7.
1991: Rudolph L Leibel; E M Berry; J Hirsch
Metabolic and hemodynamic responses to endogenous and exogenous catecholamines in formerly obese subjects.
The American journal of physiology 1991;260(4 Pt 2):R785-91.
1991: Jeffrey M Friedman; Rudolph L Leibel; N Bahary
Molecular mapping of obesity genes.
Mammalian genome : official journal of the International Mammalian Genome Society 1991;1(3):130-44.
1991: Jeffrey M Friedman; Rudolph L Leibel; N Bahary; D A Siegel; G Truett
Genetic analysis of complex disorders. Molecular mapping of obesity genes in mice and humans.
Annals of the New York Academy of Sciences 1991;630():100-15.
1990: N Bahary; Rudolph L Leibel; L Joseph; Jeffrey M Friedman
Molecular mapping of the mouse db mutation.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(21):8642-6.
1990: N K Edens; Rudolph L Leibel; J Hirsch
Mechanism of free fatty acid re-esterification in human adipocytes in vitro.
Journal of lipid research 1990;31(8):1423-31.
1990: N K Edens; Rudolph L Leibel; J Hirsch
Lipolytic effects on diacylglycerol accumulation in human adipose tissue in vitro.
Journal of lipid research 1990;31(8):1351-9.
1990: E Presta; Rudolph L Leibel; J Hirsch
Regional changes in adrenergic receptor status during hypocaloric intake do not predict changes in adipocyte size or body shape.
Metabolism: clinical and experimental 1990;39(3):307-15.
1990: R M Smiley; S Paul; M D Browning; Rudolph L Leibel; J Hirsch
Protein phosphorylation in isolated human adipocytes-adrenergic control of the phosphorylation of hormone-sensitive lipase.
Life sciences 1990;47(10):849-58.
1990: Rudolph L Leibel; N Bahary; Jeffrey M Friedman
Genetic variation and nutrition in obesity: approaches to the molecular genetics of obesity.
World review of nutrition and dietetics 1990;63():90-101.
1989: Rudolph L Leibel; N K Edens; S K Fried
Physiologic basis for the control of body fat distribution in humans.
Annual review of nutrition 1989;9():417-43.
1989: J Hirsch; S K Fried; N K Edens; Rudolph L Leibel
The fat cell.
The Medical clinics of North America 1989;73(1):83-96.
1987: R A Forse; Rudolph L Leibel; J Askanazi; J Hirsch; J M Kinney
Adrenergic control of adipocyte lipolysis in trauma and sepsis.
Annals of surgery 1987;206(6):744-51.