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Carlos Barbas
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41
Lerner, Richard
29
Tanaka, Fujie
26
Burton, Dennis
22
Rader, Christoph
17
Popkov, Mikhail
15
Segal, David
12
Sinha, Subhash
10
Beerli, Roger
9
Fuller, Roberta
8
Dreier, Birgit
8
List, Benjamin
7
Ditzel, Henrik
7
Chowdari, Naidu
7
Blancafort, Pilar
7
Shabat, Doron
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All Publications
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2009: Tschulena Ulrich; Peterson Kenneth R; Gonzalez Beatriz; Fedosyuk Halyna; Barbas Carlos F
Positive selection of DNA-protein interactions in mammalian cells through phenotypic coupling with retrovirus production.
Nature structural & molecular biology 2009;16(11):1195-9.
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2009: Bui Tommy; Syed Salahuddin; Barbas Carlos F
Thiourea-catalyzed highly enantio- and diastereoselective additions of oxindoles to nitroolefins: application to the formal synthesis of (+)-physostigmine.
Journal of the American Chemical Society 2009;131(25):8758-9.
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2009: Gavrilyuk Julia I; Wuellner Ulrich; Salahuddin Syed; Goswami Rajib K; Sinha Subhash C; Barbas Carlos F
An efficient chemical approach to bispecific antibodies and antibodies of high valency.
Bioorganic & medicinal chemistry letters 2009;19(14):3716-20.
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2009: Gordley Russell M; Gersbach Charles A; Barbas Carlos F
Synthesis of programmable integrases.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(13):5053-8.
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2009: Popkov Mikhail; Gonzalez Beatriz; Sinha Subhash C; Barbas Carlos F
Instant immunity through chemically programmable vaccination and covalent self-assembly.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(11):4378-83.
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2009: Gavrilyuk Julia I; Wuellner Ulrich; Barbas Carlos F
Beta-lactam-based approach for the chemical programming of aldolase antibody 38C2.
Bioorganic & medicinal chemistry letters 2009;19(5):1421-4.
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2008: Magnenat L; Schwimmer L J; Barbas C F
Drug-inducible and simultaneous regulation of endogenous genes by single-chain nuclear receptor-based zinc-finger transcription factor gene switches.
Gene therapy 2008;15(17):1223-32.
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2008: Tanaka Fujie; Hu Yunfeng; Sutton Jori; Asawapornmongkol Lily; Fuller Roberta; Olson Arthur J; Barbas Carlos F; Lerner Richard A
Selection of phage-displayed peptides that bind to a particular ligand-bound antibody.
Bioorganic & medicinal chemistry 2008;16(11):5926-31.
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2008: Ramasastry S S V; Albertshofer Klaus; Utsumi Naoto; Barbas Carlos F
Water-compatible organocatalysts for direct asymmetric syn-aldol reactions of dihydroxyacetone and aldehydes.
Organic letters 2008;10(8):1621-4.
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2008: Jiang Lin; Althoff Eric A; Clemente Fernando R; Doyle Lindsey; Röthlisberger Daniela; Zanghellini Alexandre; Gallaher Jasmine L; Betker Jamie L; Tanaka Fujie; Barbas Carlos F; Hilvert Donald; Houk Kendall N; Stoddard Barry L; Baker David
De novo computational design of retro-aldol enzymes.
Science (New York, N.Y.) 2008;319(5868):1387-91.
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2008: Blancafort Pilar; Tschan Mario P; Bergquist Sharon; Guthy Daniel; Brachat Arndt; Sheeter Dennis A; Torbett Bruce E; Erdmann Dirk; Barbas Carlos F
Modulation of drug resistance by artificial transcription factors.
Molecular cancer therapeutics 2008;7(3):688-97.
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2008: Zhang Haile; Mitsumori Susumu; Utsumi Naoto; Imai Masanori; Garcia-Delgado Noemi; Mifsud Maria; Albertshofer Klaus; Cheong Paul Ha-Yeon; Houk K N; Tanaka Fujie; Barbas Carlos F
Catalysis of 3-pyrrolidinecarboxylic acid and related pyrrolidine derivatives in enantioselective anti-Mannich-type reactions: importance of the 3-acid group on pyrrolidine for stereocontrol.
Journal of the American Chemical Society 2008;130(3):875-86.
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2008: Alonso Diego A; Kitagaki Shinji; Utsumi Naoto; Barbas Carlos F
Towards organocatalytic polyketide synthases with diverse electrophile scope: trifluoroethyl thioesters as nucleophiles in organocatalytic Michael reactions and beyond.
Angewandte Chemie (International ed. in English) 2008;47(24):4588-91.
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2008: Barbas Carlos F
Organocatalysis lost: modern chemistry, ancient chemistry, and an unseen biosynthetic apparatus.
Angewandte Chemie (International ed. in English) 2008;47(1):42-7.
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2007: Utsumi Naoto; Imai Masanori; Tanaka Fujie; Ramasastry S S V; Barbas Carlos F
Mimicking aldolases through organocatalysis: syn-selective aldol reactions with protected dihydroxyacetone.
Organic letters 2007;9(17):3445-8.
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2007: Tanaka Fujie; Fuller Roberta; Asawapornmongkol Lily; Warsinke Axel; Gobuty Sarah; Barbas Carlos F
Development of a small peptide tag for covalent labeling of proteins.
Bioconjugate chemistry 2007;18(4):1318-24.
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2007: Nomura Wataru; Barbas Carlos F
In vivo site-specific DNA methylation with a designed sequence-enabled DNA methylase.
Journal of the American Chemical Society 2007;129(28):8676-7.
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2007: Abraham Sunny; Guo Fang; Li Lian-Sheng; Rader Christoph; Liu Cheng; Barbas Carlos F; Lerner Richard A; Sinha Subhash C
Synthesis of the next-generation therapeutic antibodies that combine cell targeting and antibody-catalyzed prodrug activation.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(13):5584-9.
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2007: Gordley Russell M; Smith Justin D; Gräslund Torbjörn; Barbas Carlos F
Evolution of programmable zinc finger-recombinases with activity in human cells.
Journal of molecular biology 2007;367(3):802-13.
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2007: Shamis Marina; Barbas Carlos F; Shabat Doron
A new visual screening assay for catalytic antibodies with retro-aldol retro-Michael activity.
Bioorganic & medicinal chemistry letters 2007;17(5):1172-5.
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2007: Ramasastry S S V; Zhang Haile; Tanaka Fujie; Barbas Carlos F
Direct catalytic asymmetric synthesis of anti-1,2-amino alcohols and syn-1,2-diols through organocatalytic anti-Mannich and syn-aldol reactions.
Journal of the American Chemical Society 2007;129(2):288-9.
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2007: Ramasastry S S V; Albertshofer Klaus; Utsumi Naoto; Tanaka Fujie; Barbas Carlos F
Mimicking fructose and rhamnulose aldolases: organocatalytic syn-aldol reactions with unprotected dihydroxyacetone.
Angewandte Chemie (International ed. in English) 2007;46(29):5572-5.
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2007: Utsumi Naoto; Zhang Haile; Tanaka Fujie; Barbas Carlos F
A way to highly enantiomerically enriched aza-Morita-Baylis-Hillman-type products.
Angewandte Chemie (International ed. in English) 2007;46(11):1878-80.
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2007: Sinha Subhash C; Das Sanjib; Li Lian-Sheng; Lerner Richard A; Barbas Carlos F
Preparation of integrin alpha(v)beta3-targeting Ab 38C2 constructs.
Nature protocols 2007;2(2):449-56.
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2006: Swan C H; Bühler B; Steinberger P; Tschan M P; Barbas C F; Torbett B E
T-cell protection and enrichment through lentiviral CCR5 intrabody gene delivery.
Gene therapy 2006;13(20):1480-92.
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2006: Popkov Mikhail; Rader Christoph; Gonzalez Beatriz; Sinha Subhash C; Barbas Carlos F
Small molecule drug activity in melanoma models may be dramatically enhanced with an antibody effector.
International journal of cancer. Journal international du cancer 2006;119(5):1194-207.
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2006: Zhang Haile; Mifsud Maria; Tanaka Fujie; Barbas Carlos F
3-Pyrrolidinecarboxylic acid for direct catalytic asymmetric anti-Mannich-type reactions of unmodified ketones.
Journal of the American Chemical Society 2006;128(30):9630-1.
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2006: Mandell Jeffrey G; Barbas Carlos F
Zinc Finger Tools: custom DNA-binding domains for transcription factors and nucleases.
Nucleic acids research 2006;34(Web Server issue):W516-23.
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2006: Guo Fang; Das Sanjib; Mueller Barbara M; Barbas Carlos F; Lerner Richard A; Sinha Subhash C
Breaking the one antibody-one target axiom.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(29):11009-14.
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2006: Chowdari Naidu S; Ahmad Moballigh; Albertshofer Klaus; Tanaka Fujie; Barbas Carlos F
Expedient synthesis of chiral 1,2- and 1,4-diamines: protecting group dependent regioselectivity in direct organocatalytic asymmetric Mannich reactions.
Organic letters 2006;8(13):2839-42.
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2006: Suri Jeff T; Mitsumori Susumu; Albertshofer Klaus; Tanaka Fujie; Barbas Carlos F
Dihydroxyacetone variants in the organocatalytic construction of carbohydrates: mimicking tagatose and fuculose aldolases.
The Journal of organic chemistry 2006;71(10):3822-8.
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2006: Eberhardy Scott R; Goncalves Joao; Coelho Sofia; Segal David J; Berkhout Ben; Barbas Carlos F
Inhibition of human immunodeficiency virus type 1 replication with artificial transcription factors targeting the highly conserved primer-binding site.
Journal of virology 2006;80(6):2873-83.
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2006: Mitsumori Susumu; Zhang Haile; Ha-Yeon Cheong Paul; Houk K N; Tanaka Fujie; Barbas Carlos F
Direct asymmetric anti-Mannich-type reactions catalyzed by a designed amino acid.
Journal of the American Chemical Society 2006;128(4):1040-1.
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2005: Lund Caren V; Popkov Mikhail; Magnenat Laurent; Barbas Carlos F
Zinc finger transcription factors designed for bispecific coregulation of ErbB2 and ErbB3 receptors: insights into ErbB receptor biology.
Molecular and cellular biology 2005;25(20):9082-91.
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2005: Dreier Birgit; Fuller Roberta P; Segal David J; Lund Caren V; Blancafort Pilar; Huber Adrian; Koksch Beate; Barbas Carlos F
Development of zinc finger domains for recognition of the 5'-CNN-3' family DNA sequences and their use in the construction of artificial transcription factors.
The Journal of biological chemistry 2005;280(42):35588-97.
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2005: Alwin Stephen; Gere Maja B; Guhl Eva; Effertz Karin; Barbas Carlos F; Segal David J; Weitzman Matthew D; Cathomen Toni
Custom zinc-finger nucleases for use in human cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(4):610-7.
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2005: Weinstain Roy; Lerner Richard A; Barbas Carlos F; Shabat Doron
Antibody-catalyzed asymmetric intramolecular Michael addition of aldehydes and ketones to yield the disfavored cis-product.
Journal of the American Chemical Society 2005;127(38):13104-5.
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2005: Suri Jeff T; Steiner Derek D; Barbas Carlos F
Organocatalytic enantioselective synthesis of metabotropic glutamate receptor ligands.
Organic letters 2005;7(18):3885-8.
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2005: Blancafort Pilar; Chen Emily I; Gonzalez Beatriz; Bergquist Sharon; Zijlstra Andries; Guthy Daniel; Brachat Arndt; Brakenhoff Ruud H; Quigley James P; Erdmann Dirk; Barbas Carlos F
Genetic reprogramming of tumor cells by zinc finger transcription factors.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(33):11716-21.
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2005: Amir Roey J; Popkov Mikhail; Lerner Richard A; Barbas Carlos F; Shabat Doron
Prodrug activation gated by a molecular "OR" logic trigger.
Angewandte Chemie (International ed. in English) 2005;44(28):4378-81.
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2005: Chen Emily I; Florens Laurence; Axelrod Fumiko T; Monosov Edward; Barbas Carlos F; Yates John R; Felding-Habermann Brunhilde; Smith Jeffrey W
Maspin alters the carcinoma proteome.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(9):1123-4.
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2005: Jendreyko Nina; Popkov Mikhail; Rader Christoph; Barbas Carlos F
Phenotypic knockout of VEGF-R2 and Tie-2 with an intradiabody reduces tumor growth and angiogenesis in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(23):8293-8.
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2005: Steiner Derek D; Mase Nobuyuki; Barbas Carlos F
Direct asymmetric alpha-fluorination of aldehydes.
Angewandte Chemie (International ed. in English) 2005;44(24):3706-10.
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2005: Tanaka Fujie; Fuller Roberta; Barbas Carlos F
Development of small designer aldolase enzymes: catalytic activity, folding, and substrate specificity.
Biochemistry 2005;44(20):7583-92.
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2005: Ramachary Dhevalapally B; Barbas Carlos F
Direct amino acid-catalyzed asymmetric desymmetrization of meso-compounds: tandem aminoxylation/O-N bond heterolysis reactions.
Organic letters 2005;7(8):1577-80.
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2005: Suri Jeff T; Ramachary Dhevalapally B; Barbas Carlos F
Mimicking dihydroxy acetone phosphate-utilizing aldolases through organocatalysis: a facile route to carbohydrates and aminosugars.
Organic letters 2005;7(7):1383-5.
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2005: Chowdari Naidu S; Barbas Carlos F
Total synthesis of LFA-1 antagonist BIRT-377 via organocatalytic asymmetric construction of a quaternary stereocenter.
Organic letters 2005;7(5):867-70.
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2005: Popkov Mikhail; Jendreyko Nina; McGavern Dorian B; Rader Christoph; Barbas Carlos F
Targeting tumor angiogenesis with adenovirus-delivered anti-Tie-2 intrabody.
Cancer research 2005;65(3):972-81.
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2005: Gräslund Torbjörn; Li Xuelin; Magnenat Laurent; Popkov Mikhail; Barbas Carlos F
Exploring strategies for the design of artificial transcription factors: targeting sites proximal to known regulatory regions for the induction of gamma-globin expression and the treatment of sickle cell disease.
The Journal of biological chemistry 2005;280(5):3707-14.
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2005: Haba Keren; Popkov Mikhail; Shamis Marina; Lerner Richard A; Barbas Carlos F; Shabat Doron
Single-triggered trimeric prodrugs.
Angewandte Chemie (International ed. in English) 2005;44(5):716-20.
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2004: Blancafort Pilar; Segal David J; Barbas Carlos F
Designing transcription factor architectures for drug discovery.
Molecular pharmacology 2004;66(6):1361-71.
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2004: Li Lian-Sheng; Rader Christoph; Matsushita Masayuki; Das Sanjib; Barbas Carlos F; Lerner Richard A; Sinha Subhash C
Chemical adaptor immunotherapy: design, synthesis, and evaluation of novel integrin-targeting devices.
Journal of medicinal chemistry 2004;47(23):5630-40.
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2004: Zhu Xueyong; Tanaka Fujie; Hu Yunfeng; Heine Andreas; Fuller Roberta; Zhong Guofu; Olson Arthur J; Lerner Richard A; Barbas Carlos F; Wilson Ian A
The origin of enantioselectivity in aldolase antibodies: crystal structure, site-directed mutagenesis, and computational analysis.
Journal of molecular biology 2004;343(5):1269-80.
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2004: Ramachary Dhevalapally B; Barbas Carlos F
Towards organo-click chemistry: development of organocatalytic multicomponent reactions through combinations of aldol, Wittig, Knoevenagel, Michael, Diels-Alder and Huisgen cycloaddition reactions.
Chemistry (Weinheim an der Bergstrasse, Germany) 2004;10(21):5323-31.
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2004: Sinha Subhash C; Li Lian-Sheng; Watanabe Shin-Ichi; Kaltgrad Eiton; Tanaka Fujie; Rader Christoph; Lerner Richard A; Barbas Carlos F
Aldolase antibody activation of prodrugs of potent aldehyde-containing cytotoxics for selective chemotherapy.
Chemistry (Weinheim an der Bergstrasse, Germany) 2004;10(21):5467-72.
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2004: Ramachary D B; Anebouselvy K; Chowdari Naidu S; Barbas Carlos F
Direct organocatalytic asymmetric heterodomino reactions: the Knoevenagel/Diels-Alder/epimerization sequence for the highly diastereoselective synthesis of symmetrical and nonsymmetrical synthons of benzoannelated centropolyquinanes.
The Journal of organic chemistry 2004;69(18):5838-49.
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2004: Popkov Mikhail; Rader Christoph; Barbas Carlos F
Isolation of human prostate cancer cell reactive antibodies using phage display technology.
Journal of immunological methods 2004;291(1-2):137-51.
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2004: Notz Wolfgang; Tanaka Fujie; Barbas Carlos F
Enamine-based organocatalysis with proline and diamines: the development of direct catalytic asymmetric Aldol, Mannich, Michael, and Diels-alder reactions.
Accounts of chemical research 2004;37(8):580-91.
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2004: Magnenat Laurent; Blancafort Pilar; Barbas Carlos F
In vivo selection of combinatorial libraries and designed affinity maturation of polydactyl zinc finger transcription factors for ICAM-1 provides new insights into gene regulation.
Journal of molecular biology 2004;341(3):635-49.
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2004: Tanaka Fujie; Mase Nobuyuki; Barbas Carlos F
Determination of cysteine concentration by fluorescence increase: reaction of cysteine with a fluorogenic aldehyde.
Chemical communications (Cambridge, England) 2004;(15):1762-3.
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2004: Shim Hyunbo; Karlström Amelie; Touami Sofia M; Fuller Roberta P; Barbas Carlos F
Flow cytometric screening of aldolase catalytic antibodies.
Bioorganic & medicinal chemistry letters 2004;14(15):4065-8.
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2004: Mase Nobuyuki; Thayumanavan Rajeswari; Tanaka Fujie; Barbas Carlos F
Direct asymmetric organocatalytic Michael reactions of alpha,alpha-disubstituted aldehydes with beta-nitrostyrenes for the synthesis of quaternary carbon-containing products.
Organic letters 2004;6(15):2527-30.
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2004: Chowdari Naidu S; Suri Jeff T; Barbas Carlos F
Asymmetric synthesis of quaternary alpha- and beta-amino acids and beta-lactams via proline-catalyzed mannich reactions with branched aldehyde donors.
Organic letters 2004;6(15):2507-10.
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2004: Lund Caren V; Blancafort Pilar; Popkov Mikhail; Barbas Carlos F
Promoter-targeted phage display selections with preassembled synthetic zinc finger libraries for endogenous gene regulation.
Journal of molecular biology 2004;340(3):599-613.
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2004: Popkov Mikhail; Jendreyko Nina; Gonzalez-Sapienza Gualberto; Mage Rose G; Rader Christoph; Barbas Carlos F
Human/mouse cross-reactive anti-VEGF receptor 2 recombinant antibodies selected from an immune b9 allotype rabbit antibody library.
Journal of immunological methods 2004;288(1-2):149-64.
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2004: Tanaka Fujie; Flores Fabiola; Kubitz Diane; Lerner Richard A; Barbas Carlos F
Antibody-catalyzed aminolysis of a chloropyrimidine derivative.
Chemical communications (Cambridge, England) 2004;(10):1242-3.
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2004: Segal David J; Gonçalves João; Eberhardy Scott; Swan Christina H; Torbett Bruce E; Li Xuelin; Barbas Carlos F
Attenuation of HIV-1 replication in primary human cells with a designed zinc finger transcription factor.
The Journal of biological chemistry 2004;279(15):14509-19.
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2004: Tanaka Fujie; Mase Nobuyuki; Barbas Carlos F
Design and use of fluorogenic aldehydes for monitoring the progress of aldehyde transformations.
Journal of the American Chemical Society 2004;126(12):3692-3.
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2004: Chung Junho; Rader Christoph; Popkov Mikhail; Hur Young-Mi; Kim Hyun-Kyung; Lee Young-Joon; Barbas Carlos F
Integrin alphaIIbbeta3-specific synthetic human monoclonal antibodies and HCDR3 peptides that potently inhibit platelet aggregation.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(2):361-3.
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2004: Tanaka Fujie; Fuller Roberta; Shim Hyunbo; Lerner Richard A; Barbas Carlos F
Evolution of aldolase antibodies in vitro: correlation of catalytic activity and reaction-based selection.
Journal of molecular biology 2004;335(4):1007-18.
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2003: Notz Wolfgang; Tanaka Fujie; Watanabe Shin-Ichi; Chowdari Naidu S; Turner James M; Thayumanavan Rajeswari; Barbas Carlos F
The direct organocatalytic asymmetric mannich reaction: unmodified aldehydes as nucleophiles.
The Journal of organic chemistry 2003;68(25):9624-34.
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2003: Mase Nobuyuki; Tanaka Fujie; Barbas Carlos F
Rapid fluorescent screening for bifunctional amine-acid catalysts: efficient syntheses of quaternary carbon-containing aldols under organocatalysis.
Organic letters 2003;5(23):4369-72.
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2003: Jendreyko Nina; Popkov Mikhail; Beerli Roger R; Chung Junho; McGavern Dorian B; Rader Christoph; Barbas Carlos F
Intradiabodies, bispecific, tetravalent antibodies for the simultaneous functional knockout of two cell surface receptors.
The Journal of biological chemistry 2003;278(48):47812-9.
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2003: Ramachary D B; Chowdari Naidu S; Barbas Carlos F
Organocatalytic asymmetric domino knoevenagel/diels-alder reactions: a bioorganic approach to the diastereospecific and enantioselective construction of highly substituted spiro[5,5]undecane-1,5,9-triones.
Angewandte Chemie (International ed. in English) 2003;42(35):4233-7.
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2003: Rader Christoph; Turner James M; Heine Andreas; Shabat Doron; Sinha Subhash C; Wilson Ian A; Lerner Richard A; Barbas Carlos F
A humanized aldolase antibody for selective chemotherapy and adaptor immunotherapy.
Journal of molecular biology 2003;332(4):889-99.
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2003: Gottesfeld Joel M; Barbas Carlos F
RNA as a transcriptional activator.
Chemistry & biology 2003;10(7):584-5.
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2003: Holbro Thomas; Beerli Roger R; Maurer Francisca; Koziczak Magdalena; Barbas Carlos F; Hynes Nancy E
The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(15):8933-8.
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2003: Tanaka Fujie; Thayumanavan Rajeswari; Barbas Carlos F
Fluorescent detection of carbon-carbon bond formation.
Journal of the American Chemical Society 2003;125(28):8523-8.
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2003: Chowdari Naidu S; Ramachary D B; Barbas Carlos F
Organocatalytic asymmetric assembly reactions: one-pot synthesis of functionalized beta-amino alcohols from aldehydes, ketones, and azodicarboxylates.
Organic letters 2003;5(10):1685-8.
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2003: Berry Jody D; Rutherford John; Silverman Gregg J; Kaul Rupert; Elia Marikka; Gobuty Sarah; Fuller Roberta; Plummer Francis A; Barbas Carlos F
Development of functional human monoclonal single-chain variable fragment antibody against HIV-1 from human cervical B cells.
Hybridoma and hybridomics 2003;22(2):97-108.
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2003: Rader Christoph; Sinha Subhash C; Popkov Mikhail; Lerner Richard A; Barbas Carlos F
Chemically programmed monoclonal antibodies for cancer therapy: adaptor immunotherapy based on a covalent antibody catalyst.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(9):5396-400.
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2003: Segal David J; Stege Justin T; Barbas Carlos F
Zinc fingers and a green thumb: manipulating gene expression in plants.
Current opinion in plant biology 2003;6(2):163-8.
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2003: Hyland Stephen; Beerli Roger R; Barbas Carlos F; Hynes Nancy E; Wels Winfried
Generation and functional characterization of intracellular antibodies interacting with the kinase domain of human EGF receptor.
Oncogene 2003;22(10):1557-67.
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2003: Blancafort Pilar; Magnenat Laurent; Barbas Carlos F
Scanning the human genome with combinatorial transcription factor libraries.
Nature biotechnology 2003;21(3):269-74.
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2003: Berry Jody D; Licea Alexei; Popkov Mikhail; Cortez Xochitl; Fuller Roberta; Elia Marikka; Kerwin Lisa; Kubitz Diane; Barbas Carlos F
Rapid monoclonal antibody generation via dendritic cell targeting in vivo.
Hybridoma and hybridomics 2003;22(1):23-31.
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2003: Segal David J; Beerli Roger R; Blancafort Pilar; Dreier Birgit; Effertz Karin; Huber Adrian; Koksch Beate; Lund Caren V; Magnenat Laurent; Valente David; Barbas Carlos F
Evaluation of a modular strategy for the construction of novel polydactyl zinc finger DNA-binding proteins.
Biochemistry 2003;42(7):2137-48.
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2003: Lin Qing; Barbas Carlos F; Schultz Peter G
Small-molecule switches for zinc finger transcription factors.
Journal of the American Chemical Society 2003;125(3):612-3.
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2003: Popkov Mikhail; Mage Rose G; Alexander Cornelius B; Thundivalappil Sujatha; Barbas Carlos F; Rader Christoph
Rabbit immune repertoires as sources for therapeutic monoclonal antibodies: the impact of kappa allotype-correlated variation in cysteine content on antibody libraries selected by phage display.
Journal of molecular biology 2003;325(2):325-35.
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2002: Córdova Armando; Notz Wolfgang; Barbas Carlos F
Direct organocatalytic aldol reactions in buffered aqueous media.
Chemical communications (Cambridge, England) 2002;(24):3024-5.
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2002: Stege Justin T; Guan Xuen; Ho Thao; Beachy Roger N; Barbas Carlos F
Controlling gene expression in plants using synthetic zinc finger transcription factors.
The Plant journal : for cell and molecular biology 2002;32(6):1077-86.
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2002: Watanabe Shin-ichi; Córdova Armando; Tanaka Fujie; Barbas Carlos F
One-pot asymmetric synthesis of beta-cyanohydroxymethyl alpha-amino acid derivatives: formation of three contiguous stereogenic centers.
Organic letters 2002;4(25):4519-22.
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2002: Rader Christoph; Popkov Mikhail; Neves John A; Barbas Carlos F
Integrin alpha(v)beta3 targeted therapy for Kaposi's sarcoma with an in vitro evolved antibody.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(14):2000-2.
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2002: Tanaka Fujie; Barbas Carlos F
Reactive immunization: a unique approach to catalytic antibodies.
Journal of immunological methods 2002;269(1-2):67-79.
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2002: Turner James M; Larsen Nicholas A; Basran Amrik; Barbas Carlos F; Bruce Neil C; Wilson Ian A; Lerner Richard A
Biochemical characterization and structural analysis of a highly proficient cocaine esterase.
Biochemistry 2002;41(41):12297-307.
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2002: Tanaka Fujie; Barbas Carlos F
A modular assembly strategy for improving the substrate specificity of small catalytic peptides.
Journal of the American Chemical Society 2002;124(14):3510-1.
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2002: Córdova Armando; Watanabe Shin-ichi; Tanaka Fujie; Notz Wolfgang; Barbas Carlos F
A highly enantioselective route to either enantiomer of both alpha- and beta-amino acid derivatives.
Journal of the American Chemical Society 2002;124(9):1866-7.
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2002: Córdova Armando; Notz Wolfgang; Zhong Guofu; Betancort Juan M; Barbas Carlos F
A highly enantioselective amino acid-catalyzed route to functionalized alpha-amino acids.
Journal of the American Chemical Society 2002;124(9):1842-3.
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2002: Beerli Roger R; Barbas Carlos F
Engineering polydactyl zinc-finger transcription factors.
Nature biotechnology 2002;20(2):135-41.
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2002: Córdova Armando; Notz Wolfgang; Barbas Carlos F
Proline-catalyzed one-step asymmetric synthesis of 5-hydroxy-(2E)-hexenal from acetaldehyde.
The Journal of organic chemistry 2002;67(1):301-3.
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2001: Segal D J; Barbas C F
Custom DNA-binding proteins come of age: polydactyl zinc-finger proteins.
Current opinion in biotechnology 2001;12(6):632-7.
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2001: Betancort J M; Barbas C F
Catalytic direct asymmetric Michael reactions: taming naked aldehyde donors.
Organic letters 2001;3(23):3737-40.
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2001: Tanaka F; Kerwin L; Kubitz D; Lerner R A; Barbas C F
Visualizing antibody-catalyzed retro-aldol-retro-Michael reactions.
Bioorganic & medicinal chemistry letters 2001;11(22):2983-6.
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2001: Dreier B; Beerli R R; Segal D J; Flippin J D; Barbas C F
Development of zinc finger domains for recognition of the 5'-ANN-3' family of DNA sequences and their use in the construction of artificial transcription factors.
The Journal of biological chemistry 2001;276(31):29466-78.
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2001: Sakthivel K; Notz W; Bui T; Barbas C F
Amino acid catalyzed direct asymmetric aldol reactions: a bioorganic approach to catalytic asymmetric carbon-carbon bond-forming reactions.
Journal of the American Chemical Society 2001;123(22):5260-7.
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2001: Shabat D; Lode H N; Pertl U; Reisfeld R A; Rader C; Lerner R A; Barbas C F
In vivo activity in a catalytic antibody-prodrug system: Antibody catalyzed etoposide prodrug activation for selective chemotherapy.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(13):7528-33.
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2000: Dreier B; Segal D J; Barbas C F
Insights into the molecular recognition of the 5'-GNN-3' family of DNA sequences by zinc finger domains.
Journal of molecular biology 2000;303(4):489-502.
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2000: Steinberger P; Sutton J K; Rader C; Elia M; Barbas C F
Generation and characterization of a recombinant human CCR5-specific antibody. A phage display approach for rabbit antibody humanization.
The Journal of biological chemistry 2000;275(46):36073-8.
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2000: Beerli R R; Schopfer U; Dreier B; Barbas C F
Chemically regulated zinc finger transcription factors.
The Journal of biological chemistry 2000;275(42):32617-27.
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2000: Andris-Widhopf J; Rader C; Steinberger P; Fuller R; Barbas C F
Methods for the generation of chicken monoclonal antibody fragments by phage display.
Journal of immunological methods 2000;242(1-2):159-81.
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2000: Turner J M; Bui T; Lerner R A; Barbas C F; List B
An efficient benchtop system for multigram-scale kinetic resolutions using aldolase antibodies.
Chemistry (Weinheim an der Bergstrasse, Germany) 2000;6(15):2772-4.
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2000: Rader C; Ritter G; Nathan S; Elia M; Gout I; Jungbluth A A; Cohen L S; Welt S; Old L J; Barbas C F
The rabbit antibody repertoire as a novel source for the generation of therapeutic human antibodies.
The Journal of biological chemistry 2000;275(18):13668-76.
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2000: Karlstrom A; Zhong G; Rader C; Larsen N A; Heine A; Fuller R; List B; Tanaka F; Wilson I A; Barbas C F; Lerner R A
Using antibody catalysis to study the outcome of multiple evolutionary trials of a chemical task.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(8):3878-83.
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2000: Segal D J; Barbas C F
Design of novel sequence-specific DNA-binding proteins.
Current opinion in chemical biology 2000;4(1):34-9.
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2000: Beerli R R; Dreier B; Barbas C F
Positive and negative regulation of endogenous genes by designed transcription factors.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(4):1495-500.
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2000: Steinberger P; Andris-Widhopf J; Bühler B; Torbett B E; Barbas C F
Functional deletion of the CCR5 receptor by intracellular immunization produces cells that are refractory to CCR5-dependent HIV-1 infection and cell fusion.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(2):805-10.
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2000: Barbas C F; Rader C; Segal D J; List B; Turner J M
From catalytic asymmetric synthesis to the transcriptional regulation of genes: in vivo and in vitro evolution of proteins.
Advances in protein chemistry 2000;55():317-66.
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1999: Sinha S C; Sun J; Miller G; Barbas C F; Lerner R A
Sets of aldolase antibodies with antipodal reactivities. Formal synthesis of epothilone E by large-scale antibody-catalyzed resolution of thiazole aldol.
Organic letters 1999;1(10):1623-6.
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1999: List B; Lerner R A; Barbas C F
Enantioselective aldol cyclodehydrations catalyzed by antibody 38C2.
Organic letters 1999;1(1):59-61.
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1999: Shabat D; Rader C; List B; Lerner R A; Barbas C F
Multiple event activation of a generic prodrug trigger by antibody catalysis.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(12):6925-30.
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1999: Segal D J; Dreier B; Beerli R R; Barbas C F
Toward controlling gene expression at will: selection and design of zinc finger domains recognizing each of the 5'-GNN-3' DNA target sequences.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(6):2758-63.
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1998: List B; Barbas C F; Lerner R A
Aldol sensors for the rapid generation of tunable fluorescence by antibody catalysis.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(26):15351-5.
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1998: Beerli R R; Segal D J; Dreier B; Barbas C F
Toward controlling gene expression at will: specific regulation of the erbB-2/HER-2 promoter by using polydactyl zinc finger proteins constructed from modular building blocks.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(25):14628-33.
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1998: Sinha S C; Barbas C F; Lerner R A
The antibody catalysis route to the total synthesis of epothilones.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(25):14603-8.
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1998: Rader C; Cheresh D A; Barbas C F
A phage display approach for rapid antibody humanization: designed combinatorial V gene libraries.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(15):8910-5.
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1998: Barbas C F; List B
Alchemy, enzymes, and the blind-watchmaker.
Nature biotechnology 1998;16(5):423-4.
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1997: Barbas C F; Heine A; Zhong G; Hoffmann T; Gramatikova S; Björnestedt R; List B; Anderson J; Stura E A; Wilson I A; Lerner R A
Immune versus natural selection: antibody aldolases with enzymic rates but broader scope.
Science (New York, N.Y.) 1997;278(5346):2085-92.
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1997: Lin C H; Hoffman T Z; Wirsching P; Barbas C F; Janda K D; Lerner R A
On roads not taken in the evolution of protein catalysts: antibody steroid isomerases that use an enamine mechanism.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(22):11773-6.
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1997: Rader C; Barbas C F
Phage display of combinatorial antibody libraries.
Current opinion in biotechnology 1997;8(4):503-8.
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1997: Liu Q; Segal D J; Ghiara J B; Barbas C F
Design of polydactyl zinc-finger proteins for unique addressing within complex genomes.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(11):5525-30.
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1997: Ditzel H J; Parren P W; Binley J M; Sodroski J; Moore J P; Barbas C F; Burton D R
Mapping the protein surface of human immunodeficiency virus type 1 gp120 using human monoclonal antibodies from phage display libraries.
Journal of molecular biology 1997;267(3):684-95.
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1996: Parren P W; Fisicaro P; Labrijn A F; Binley J M; Yang W P; Ditzel H J; Barbas C F; Burton D R
In vitro antigen challenge of human antibody libraries for vaccine evaluation: the human immunodeficiency virus type 1 envelope.
Journal of virology 1996;70(12):9046-50.
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1996: Lang I M; Chuang T L; Barbas C F; Schleef R R
Purification of storage granule protein-23. A novel protein identified by phage display technology and interaction with type I plasminogen activator inhibitor.
The Journal of biological chemistry 1996;271(47):30126-35.
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1996: Lerner R A; Barbas C F
Using the process of reactive immunization to induce catalytic antibodies with complex mechanisms: aldolases.
Acta chemica Scandinavica (Copenhagen, Denmark : 1989) 1996;50(8):672-8.
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1996: Binley J M; Ditzel H J; Barbas C F; Sullivan N; Sodroski J; Parren P W; Burton D R
Human antibody responses to HIV type 1 glycoprotein 41 cloned in phage display libraries suggest three major epitopes are recognized and give evidence for conserved antibody motifs in antigen binding.
AIDS research and human retroviruses 1996;12(10):911-24.
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1996: Barbas C F; Burton D R
Selection and evolution of high-affinity human anti-viral antibodies.
Trends in biotechnology 1996;14(7):230-4.
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1996: Wagner J; Lerner R A; Barbas C F
Synthesis of five enantiomerically pure haptens designed for in vitro evolution of antibodies with peptidase activity.
Bioorganic & medicinal chemistry 1996;4(6):901-16.
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1996: Lang I M; Barbas C F; Schleef R R
Recombinant rabbit Fab with binding activity to type-1 plasminogen activator inhibitor derived from a phage-display library against human alpha-granules.
Gene 1996;172(2):295-8.
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1996: Gauduin M C; Allaway G P; Maddon P J; Barbas C F; Burton D R; Koup R A
Effective ex vivo neutralization of human immunodeficiency virus type 1 in plasma by recombinant immunoglobulin molecules.
Journal of virology 1996;70(4):2586-92.
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1996: Lerner R A; Barbas C F; Janda K D
Making enzymes.
Harvey lectures 1996;92():1-40.
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1995: Wagner J; Lerner R A; Barbas C F
Efficient aldolase catalytic antibodies that use the enamine mechanism of natural enzymes.
Science (New York, N.Y.) 1995;270(5243):1797-800.
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1995: Yang W P; Green K; Pinz-Sweeney S; Briones A T; Burton D R; Barbas C F
CDR walking mutagenesis for the affinity maturation of a potent human anti-HIV-1 antibody into the picomolar range.
Journal of molecular biology 1995;254(3):392-403.
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1995: Trkola A; Pomales A B; Yuan H; Korber B; Maddon P J; Allaway G P; Katinger H; Barbas C F; Burton D R; Ho D D
Cross-clade neutralization of primary isolates of human immunodeficiency virus type 1 by human monoclonal antibodies and tetrameric CD4-IgG.
Journal of virology 1995;69(11):6609-17.
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1995: Barbas C F
Synthetic human antibodies.
Nature medicine 1995;1(8):837-9.
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1995: Parren P W; Ditzel H J; Gulizia R J; Binley J M; Barbas C F; Burton D R; Mosier D E
Protection against HIV-1 infection in hu-PBL-SCID mice by passive immunization with a neutralizing human monoclonal antibody against the gp120 CD4-binding site.
AIDS (London, England) 1995;9(6):F1-6.
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1995: Yang W P; Wu H; Barbas C F
Surface plasmon resonance based kinetic studies of zinc finger-DNA interactions.
Journal of immunological methods 1995;183(1):175-82.
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1995: Moreno de Alborán I; Martínéz-alonso C; Barbas C F; Burton D R; Ditzel H J
Human monoclonal Fab fragments specific for viral antigens from combinatorial IgA libraries.
Immunotechnology : an international journal of immunological engineering 1995;1(1):21-8.
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1995: Wu H; Yang W P; Barbas C F
Building zinc fingers by selection: toward a therapeutic application.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(2):344-8.
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1995: Ditzel H J; Binley J M; Moore J P; Sodroski J; Sullivan N; Sawyer L S; Hendry R M; Yang W P; Barbas C F; Burton D R
Neutralizing recombinant human antibodies to a conformational V2- and CD4-binding site-sensitive epitope of HIV-1 gp120 isolated by using an epitope-masking procedure.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(2):893-906.
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1995: Moore J P; Cao Y; Qing L; Sattentau Q J; Pyati J; Koduri R; Robinson J; Barbas C F; Burton D R; Ho D D
Primary isolates of human immunodeficiency virus type 1 are relatively resistant to neutralization by monoclonal antibodies to gp120, and their neutralization is not predicted by studies with monomeric gp120.
Journal of virology 1995;69(1):101-9.
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1994: Smith J W; Hu D; Satterthwait A; Pinz-Sweeney S; Barbas C F
Building synthetic antibodies as adhesive ligands for integrins.
The Journal of biological chemistry 1994;269(52):32788-95.
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1994: Burton D R; Barbas C F
Human monoclonal antibodies: recent achievements.
Hospital practice (Office ed.) 1994;29(11):111, 114-6, 119 passim.
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1994: Roben P; Moore J P; Thali M; Sodroski J; Barbas C F; Burton D R
Recognition properties of a panel of human recombinant Fab fragments to the CD4 binding site of gp120 that show differing abilities to neutralize human immunodeficiency virus type 1.
Journal of virology 1994;68(8):4821-8.
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1994: Barbas C F; Hu D; Dunlop N; Sawyer L; Cababa D; Hendry R M; Nara P L; Burton D R
In vitro evolution of a neutralizing human antibody to human immunodeficiency virus type 1 to enhance affinity and broaden strain cross-reactivity.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(9):3809-13.
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1994: Ditzel H J; Barbas S M; Barbas C F; Burton D R
The nature of the autoimmune antibody repertoire in human immunodeficiency virus type 1 infection.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(9):3710-4.
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1994: Janda K D; Lo C H; Li T; Barbas C F; Wirsching P; Lerner R A
Direct selection for a catalytic mechanism from combinatorial antibody libraries.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(7):2532-6.
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1994: Crowe J E; Murphy B R; Chanock R M; Williamson R A; Barbas C F; Burton D R
Recombinant human respiratory syncytial virus (RSV) monoclonal antibody Fab is effective therapeutically when introduced directly into the lungs of RSV-infected mice.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(4):1386-90.
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1994: Burton D R; Barbas C F
Human antibodies from combinatorial libraries.
Advances in immunology 1994;57():191-280.
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1993: Barbas C F; Amberg W; Simoncsits A; Jones T M; Lerner R A
Selection of human anti-hapten antibodies from semisynthetic libraries.
Gene 1993;137(1):57-62.
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1993: Barbas C F; Languino L R; Smith J W
High-affinity self-reactive human antibodies by design and selection: targeting the integrin ligand binding site.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(21):10003-7.
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1993: Barbas C F
Recent advances in phage display.
Current opinion in biotechnology 1993;4(5):526-30.
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1993: Barbas C F; Rosenblum J S; Lerner R A
Direct selection of antibodies that coordinate metals from semisynthetic combinatorial libraries.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(14):6385-9.
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1993: Pannekoek H; van Meijer M; Schleef R R; Loskutoff D J; Barbas C F
Functional display of human plasminogen-activator inhibitor 1 (PAI-1) on phages: novel perspectives for structure-function analysis by error-prone DNA synthesis.
Gene 1993;128(1):135-40.
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1993: Williamson R A; Burioni R; Sanna P P; Partridge L J; Barbas C F; Burton D R
Human monoclonal antibodies against a plethora of viral pathogens from single combinatorial libraries.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(9):4141-5.
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1993: Barbas C F; Collet T A; Amberg W; Roben P; Binley J M; Hoekstra D; Cababa D; Jones T M; Williamson R A; Pilkington G R
Molecular profile of an antibody response to HIV-1 as probed by combinatorial libraries.
Journal of molecular biology 1993;230(3):812-23.
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1993: Burton D R; Barbas C F
Human antibodies to HIV-1 by recombinant DNA methods.
Chemical immunology 1993;56():112-26.
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1992: Lerner R A; Kang A S; Bain J D; Burton D R; Barbas C F
Antibodies without immunization.
Science (New York, N.Y.) 1992;258(5086):1313-4.
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1992: Collet T A; Roben P; O'Kennedy R; Barbas C F; Burton D R; Lerner R A
A binary plasmid system for shuffling combinatorial antibody libraries.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(21):10026-30.
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1992: Barbas C F; Crowe J E; Cababa D; Jones T M; Zebedee S L; Murphy B R; Chanock R M; Burton D R
Human monoclonal Fab fragments derived from a combinatorial library bind to respiratory syncytial virus F glycoprotein and neutralize infectivity.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(21):10164-8.
-
1992: Barbas C F; Björling E; Chiodi F; Dunlop N; Cababa D; Jones T M; Zebedee S L; Persson M A; Nara P L; Norrby E
Recombinant human Fab fragments neutralize human type 1 immunodeficiency virus in vitro.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(19):9339-43.
-
1992: Barbas C F; Bain J D; Hoekstra D M; Lerner R A
Semisynthetic combinatorial antibody libraries: a chemical solution to the diversity problem.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(10):4457-61.
-
1992: Gram H; Marconi L A; Barbas C F; Collet T A; Lerner R A; Kang A S
In vitro selection and affinity maturation of antibodies from a naive combinatorial immunoglobulin library.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(8):3576-80.
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1992: Zebedee S L; Barbas C F; Hom Y L; Caothien R H; Graff R; DeGraw J; Pyati J; LaPolla R; Burton D R; Lerner R A
Human combinatorial antibody libraries to hepatitis B surface antigen.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(8):3175-9.
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1992: Duchosal M A; Eming S A; Fischer P; Leturcq D; Barbas C F; McConahey P J; Caothien R H; Thornton G B; Dixon F J; Burton D R
Immunization of hu-PBL-SCID mice and the rescue of human monoclonal Fab fragments through combinatorial libraries.
Nature 1992;355(6357):258-62.
-
1991: Lerner R A; Barbas C F; Kang A S; Burton D R
On the use of combinatorial antibody libraries to clone the "fossil record" of an individual's immune response.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(21):9705-6.
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1991: Burton D R; Barbas C F; Persson M A; Koenig S; Chanock R M; Lerner R A
A large array of human monoclonal antibodies to type 1 human immunodeficiency virus from combinatorial libraries of asymptomatic seropositive individuals.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(22):10134-7.
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1991: Barbas C F; Kang A S; Lerner R A; Benkovic S J
Assembly of combinatorial antibody libraries on phage surfaces: the gene III site.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(18):7978-82.
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1991: Kang A S; Barbas C F; Janda K D; Benkovic S J; Lerner R A
Linkage of recognition and replication functions by assembling combinatorial antibody Fab libraries along phage surfaces.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(10):4363-6.
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