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Jeffrey Leiden

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Jeffrey M Leiden
Canaries, coal mines and the drug supply.
Sung-Yun Pai; Morgan L Truitt; Chao-Nan Ting; Jeffrey M Leiden; Laurie H Glimcher; I-Cheng Ho
Critical roles for transcription factor GATA-3 in thymocyte development.
Heather P Harding; Yuhong Zhang; Huiquing Zeng; Isabel Novoa; Phoebe D Lu; Marcella Calfon; Navid Sadri; Chi Yun; Brian Popko; Richard S Paules; David F Stojdl; John C Bell; Thore Hettmann; Jeffrey M Leiden; David Ron
An integrated stress response regulates amino acid metabolism and resistance to oxidative stress.

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All Publications

2008: Jeffrey M Leiden
Canaries, coal mines and the drug supply.
Nature biotechnology 2008;26(6):624-6.
2003: Sung-Yun Pai; Morgan L Truitt; Chao-Nan Ting; Jeffrey M Leiden; Laurie H Glimcher; I-Cheng Ho
Critical roles for transcription factor GATA-3 in thymocyte development.
Immunity 2003;19(6):863-75.
2003: Heather P Harding; Yuhong Zhang; Huiquing Zeng; Isabel Novoa; Phoebe D Lu; Marcella Calfon; Navid Sadri; Chi Yun; Brian Popko; Richard S Paules; David F Stojdl; John C Bell; Thore Hettmann; Jeffrey M Leiden; David Ron
An integrated stress response regulates amino acid metabolism and resistance to oxidative stress.
Molecular cell 2003;11(3):619-33.
2003: Thore Hettmann; Joseph T Opferman; Jeffrey M Leiden; Philip G Ashton-Rickardt
A critical role for NF-kappaB transcription factors in the development of CD8+ memory-phenotype T cells.
Immunology letters 2003;85(3):297-300.
2002: Andrea D Eckhart; Richard C Fentzke; John J Lepore; Roberto Lang; Hua Lin; Robert J Lefkowitz; Walter J Koch; Jeffrey M Leiden
Inhibition of betaARK1 restores impaired biochemical beta-adrenergic receptor responsiveness but does not rescue CREB(A133) induced cardiomyopathy.
Journal of molecular and cellular cardiology 2002;34(6):669-77.
2001: Beata M Wolska; K Vijayan; Grace M Arteaga; John P Konhilas; Ronald M Phillips; R Kim; T Naya; Jeffrey M Leiden; Anne F Martin; Pieter P de Tombe; R John Solaro
Expression of slow skeletal troponin I in adult transgenic mouse heart muscle reduces the force decline observed during acidic conditions.
The Journal of physiology 2001;536(Pt 3):863-70.
2001: A F Buckley; CT Kuo; Jeffrey M Leiden
Transcription factor LKLF is sufficient to program T cell quiescence via a c-Myc-dependent pathway.
Nature immunology 2001;2(8):698-704.
2001: Gordon S Huggins; C J Bacani; J Boltax; R Aikawa; Jeffrey M Leiden
Friend of GATA 2 physically interacts with chicken ovalbumin upstream promoter-TF2 (COUP-TF2) and COUP-TF3 and represses COUP-TF2-dependent activation of the atrial natriuretic factor promoter.
The Journal of biological chemistry 2001;276(30):28029-36.
2001: Jonathan C Kentish; D T McCloskey; Joanne Layland; S Palmer; Jeffrey M Leiden; Anne F Martin; R John Solaro
Phosphorylation of troponin I by protein kinase A accelerates relaxation and crossbridge cycle kinetics in mouse ventricular muscle.
Circulation research 2001;88(10):1059-65.
2001: J Moawad; Shari L Meyerson; D Refai; Christopher L Skelly; Jeffrey M Leiden; Lewis B Schwartz
Adenoviral-mediated gene transfer in human and animal vein grafts using clinically relevant exposure times, pressures, and viral concentrations.
Annals of vascular surgery 2001;15(3):367-73.
2001: Keith A Collins; Claudia E Korcarz; Sanjeev G Shroff; James E Bednarz; Richard C Fentzke; H Lin; Jeffrey M Leiden; Roberto M Lang
Accuracy of echocardiographic estimates of left ventricular mass in mice.
American journal of physiology. Heart and circulatory physiology 2001;280(5):H1954-62.
2001: Richard C Fentzke; Claudia E Korcarz; Sanjeev G Shroff; H Lin; Jeffrey M Leiden; Roberto M Lang
The left ventricular stress-velocity relation in transgenic mice expressing a dominant negative CREB transgene in the heart.
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 2001;14(3):209-18.
2000: Thore Hettmann; Jeffrey M Leiden
NF-kappa B is required for the positive selection of CD8+ thymocytes.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(9):5004-10.
2000: Qiang Tong; Gokhan Dalgin; H Xu; Chao-Nan Ting; Jeffrey M Leiden; Gökhan S Hotamisligil
Function of GATA transcription factors in preadipocyte-adipocyte transition.
Science (New York, N.Y.) 2000;290(5489):134-8.
2000: K Nakamura; M Ahmed; E Barr; Jeffrey M Leiden; Un Jung Kang
The localization and functional contribution of striatal aromatic L-amino acid decarboxylase to L-3,4-dihydroxyphenylalanine decarboxylation in rodent parkinsonian models.
Cell transplantation 2000;9(5):567-76.
2000: Grace M Arteaga; KA Palmiter; Jeffrey M Leiden; R John Solaro
Attenuation of length dependence of calcium activation in myofilaments of transgenic mouse hearts expressing slow skeletal troponin I.
The Journal of physiology 2000;526 Pt 3():541-9.
2000: Eric C Svensson; Gordon S Huggins; F B Dardik; C E Polk; Jeffrey M Leiden
A functionally conserved N-terminal domain of the friend of GATA-2 (FOG-2) protein represses GATA4-dependent transcription.
The Journal of biological chemistry 2000;275(27):20762-9.
2000: Kirk T Spencer; K Collins; Claudia E Korcarz; Richard C Fentzke; Roberto M Lang; Jeffrey M Leiden
Effects of exercise training on LV performance and mortality in a murine model of dilated cardiomyopathy.
American journal of physiology. Heart and circulatory physiology 2000;279(1):H210-5.
2000: Eric C Svensson; Gordon S Huggins; H Lin; CJ Clendenin; F Jiang; RL Tufts; F B Dardik; Jeffrey M Leiden
A syndrome of tricuspid atresia in mice with a targeted mutation of the gene encoding Fog-2.
Nature genetics 2000;25(3):353-6.
2000: Edward Morrisey; S Musco; M Y Chen; Min Min Lu; Jeffrey M Leiden; Michael S Parmacek
The gene encoding the mitogen-responsive phosphoprotein Dab2 is differentially regulated by GATA-6 and GATA-4 in the visceral endoderm.
The Journal of biological chemistry 2000;275(26):19949-54.
2000: Thore Hettmann; K Barton; Jeffrey M Leiden
Microphthalmia due to p53-mediated apoptosis of anterior lens epithelial cells in mice lacking the CREB-2 transcription factor.
Developmental biology 2000;222(1):110-23.
2000: D J Marshall; Maria Palasis; John J Lepore; Jeffrey M Leiden
Biocompatibility of cardiovascular gene delivery catheters with adenovirus vectors: an important determinant of the efficiency of cardiovascular gene transfer.
Molecular therapy : the journal of the American Society of Gene Therapy 2000;1(5 Pt 1):423-9.
2000: TL Walunas; Bin Wang; Chyung-Ru Wang; Jeffrey M Leiden
Cutting edge: the Ets1 transcription factor is required for the development of NK T cells in mice.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(6):2857-60.
1999: Richard C Fentzke; Scott H Buck; Jitandrakumar R Patel; H Lin; Beata M Wolska; MO Stojanovic; Anne F Martin; R John Solaro; Richard L Moss; Jeffrey M Leiden
Impaired cardiomyocyte relaxation and diastolic function in transgenic mice expressing slow skeletal troponin I in the heart.
The Journal of physiology 1999;517 ( Pt 1)():143-57.
1999: Lewis B Schwartz; J Moawad; Eric C Svensson; RL Tufts; Shari L Meyerson; DA Baunoch; Jeffrey M Leiden
Adenoviral-mediated gene transfer of a constitutively active form of the retinoblastoma gene product attenuates neointimal thickening in experimental vein grafts.
Journal of vascular surgery 1999;29(5):874-81; discussion 882-3.
1999: Jeffrey M Leiden
Beating the odds: a cardiomyocyte cell line at last.
The Journal of clinical investigation 1999;103(5):591-2.
1999: Victor Mor-Avi; Claudia E Korcarz; Richard C Fentzke; H Lin; Jeffrey M Leiden; Roberto M Lang
Quantitative evaluation of left ventricular function in a TransgenicMouse model of dilated cardiomyopathy with 2-dimensional contrast echocardiography.
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 1999;12(3):209-14.
1999: Eric C Svensson; RL Tufts; C E Polk; Jeffrey M Leiden
Molecular cloning of FOG-2: a modulator of transcription factor GATA-4 in cardiomyocytes.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(3):956-61.
1999: Eric C Svensson; D J Marshall; K Woodard; H Lin; F Jiang; L Chu; Jeffrey M Leiden
Efficient and stable transduction of cardiomyocytes after intramyocardial injection or intracoronary perfusion with recombinant adeno-associated virus vectors.
Circulation 1999;99(2):201-5.
1999: Thore Hettmann; JA DiDonato; Michael Karin; Jeffrey M Leiden
An essential role for nuclear factor kappaB in promoting double positive thymocyte apoptosis.
The Journal of experimental medicine 1999;189(1):145-58.
1999: C T Kuo; Jeffrey M Leiden
Transcriptional regulation of T lymphocyte development and function.
Annual review of immunology 1999;17():149-87.
1998: Kevin P Barton; N Muthusamy; C Fischer; Chao-Nan Ting; TL Walunas; Lewis L Lanier; Jeffrey M Leiden
The Ets-1 transcription factor is required for the development of natural killer cells in mice.
Immunity 1998;9(4):555-63.
1998: N Muthusamy; Jeffrey M Leiden
A protein kinase C-, Ras-, and RSK2-dependent signal transduction pathway activates the cAMP-responsive element-binding protein transcription factor following T cell receptor engagement.
The Journal of biological chemistry 1998;273(35):22841-7.
1998: H Lin; Jeffrey C Rathmell; GS Gray; Craig Thompson; Jeffrey M Leiden; Maria-Luisa Alegre
Cytotoxic T lymphocyte antigen 4 (CTLA4) blockade accelerates the acute rejection of cardiac allografts in CD28-deficient mice: CTLA4 can function independently of CD28.
The Journal of experimental medicine 1998;188(1):199-204.
1998: AG Bassuk; K P Barton; RT Anandappa; Min Min Lu; Jeffrey M Leiden
Expression pattern of the Ets-related transcription factor Elf-1.
Molecular medicine (Cambridge, Mass.) 1998;4(6):392-401.
1998: D J Marshall; Jeffrey M Leiden
Recent advances in skeletal-muscle-based gene therapy.
Current opinion in genetics & development 1998;8(3):360-5.
1998: Richard C Fentzke; Claudia E Korcarz; Roberto M Lang; H Lin; Jeffrey M Leiden
Dilated cardiomyopathy in transgenic mice expressing a dominant-negative CREB transcription factor in the heart.
The Journal of clinical investigation 1998;101(11):2415-26.
1997: CT Kuo; Margaret L Veselits; K P Barton; Min Min Lu; CJ Clendenin; Jeffrey M Leiden
The LKLF transcription factor is required for normal tunica media formation and blood vessel stabilization during murine embryogenesis.
Genes & development 1997;11(22):2996-3006.
1997: Richard C Fentzke; Claudia E Korcarz; Sanjeev G Shroff; H Lin; J Sandelski; Jeffrey M Leiden; Roberto M Lang
Evaluation of ventricular and arterial hemodynamics in anesthetized closed-chest mice.
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 1997;10(9):915-25.
1997: CT Kuo; Margaret L Veselits; Jeffrey M Leiden
LKLF and FasL expression: correctiona and clarification.
Science (New York, N.Y.) 1997;278(5339):788-9.
1997: Eric C Svensson; H B Black; D L Dugger; S K Tripathy; E Goldwasser; Z Hao; L Chu; Jeffrey M Leiden
Long-term erythropoietin expression in rodents and non-human primates following intramuscular injection of a replication-defective adenoviral vector.
Human gene therapy 1997;8(15):1797-806.
1997: CT Kuo; Margaret L Veselits; Jeffrey M Leiden
LKLF: A transcriptional regulator of single-positive T cell quiescence and survival.
Science (New York, N.Y.) 1997;277(5334):1986-90.
1997: S Kim; H Lin; E Barr; L Chu; Jeffrey M Leiden; Michael S Parmacek
Transcriptional targeting of replication-defective adenovirus transgene expression to smooth muscle cells in vivo.
The Journal of clinical investigation 1997;100(5):1006-14.
1997: AG Bassuk; RT Anandappa; Jeffrey M Leiden
Physical interactions between Ets and NF-kappaB/NFAT proteins play an important role in their cooperative activation of the human immunodeficiency virus enhancer in T cells.
Journal of virology 1997;71(5):3563-73.
1997: A Morozov; P Shiyanov; E Barr; Jeffrey M Leiden; Pradip Raychaudhuri
Accumulation of human papillomavirus type 16 E7 protein bypasses G1 arrest induced by serum deprivation and by the cell cycle inhibitor p21.
Journal of virology 1997;71(5):3451-7.
1997: CT Kuo; Edward Morrisey; RT Anandappa; Kirsten Sigrist; Min Min Lu; Michael S Parmacek; C Soudais; Jeffrey M Leiden
GATA4 transcription factor is required for ventral morphogenesis and heart tube formation.
Genes & development 1997;11(8):1048-60.
1997: AG Bassuk; Jeffrey M Leiden
The role of Ets transcription factors in the development and function of the mammalian immune system.
Advances in immunology 1997;64():65-104.
1996: C N Ting; M C Olson; K P Barton; Jeffrey M Leiden
Transcription factor GATA-3 is required for development of the T-cell lineage.
Nature 1996;384(6608):474-8.
1996: S K Tripathy; Eric C Svensson; H B Black; E Goldwasser; M Margalith; Peter Hobart; Jeffrey M Leiden
Long-term expression of erythropoietin in the systemic circulation of mice after intramuscular injection of a plasmid DNA vector.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(20):10876-80.
1996: M W Chang; Jeffrey M Leiden
Gene therapy for vascular proliferative disorders.
Seminars in interventional cardiology : SIIC 1996;1(3):185-93.
1996: S K Tripathy; H B Black; E Goldwasser; Jeffrey M Leiden
Immune responses to transgene-encoded proteins limit the stability of gene expression after injection of replication-defective adenovirus vectors.
Nature medicine 1996;2(5):545-50.
1996: Eric C Svensson; S K Tripathy; Jeffrey M Leiden
Muscle-based gene therapy: realistic possibilities for the future.
Molecular medicine today 1996;2(4):166-72.
1996: Q Huynh; Carol Butters; Jeffrey M Leiden; Larry Tobacman
Effects of cardiac thin filament Ca2+: statistical mechanical analysis of a troponin C site II mutant.
Biophysical journal 1996;70(3):1447-55.
1996: K Barton; N Muthusamy; M Chanyangam; C Fischer; CJ Clendenin; Jeffrey M Leiden
Defective thymocyte proliferation and IL-2 production in transgenic mice expressing a dominant-negative form of CREB.
Nature 1996;379(6560):81-5.
1995: C Soudais; Malgorzata Bielinska; Markku Heikinheimo; C A MacArthur; Naoko Narita; J E Saffitz; M Celeste Simon; Jeffrey M Leiden; David B Wilson
Targeted mutagenesis of the transcription factor GATA-4 gene in mouse embryonic stem cells disrupts visceral endoderm differentiation in vitro.
Development (Cambridge, England) 1995;121(11):3877-88.
1995: M W Chang; E Barr; Min Min Lu; K Barton; Jeffrey M Leiden
Adenovirus-mediated over-expression of the cyclin/cyclin-dependent kinase inhibitor, p21 inhibits vascular smooth muscle cell proliferation and neointima formation in the rat carotid artery model of balloon angioplasty.
The Journal of clinical investigation 1995;96(5):2260-8.
1995: N Muthusamy; K Barton; Jeffrey M Leiden
Defective activation and survival of T cells lacking the Ets-1 transcription factor.
Nature 1995;377(6550):639-42.
1995: A G Bassuk; Jeffrey M Leiden
A direct physical association between ETS and AP-1 transcription factors in normal human T cells.
Immunity 1995;3(2):223-37.
1995: P S Chard; Joaquín Jordán; C J Marcuccilli; Richard J Miller; Jeffrey M Leiden; Raymond P Roos; Ghanashyam D Ghadge
Regulation of excitatory transmission at hippocampal synapses by calbindin D28k.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(11):5144-8.
1995: Ghanashyam D Ghadge; Raymond P Roos; Un Jung Kang; R Wollmann; Paul S Fishman; A M Kalynych; E Barr; Jeffrey M Leiden
CNS gene delivery by retrograde transport of recombinant replication-defective adenoviruses.
Gene therapy 1995;2(2):132-7.
1995: Kerry S McDonald; Loren J Field; Michael S Parmacek; Mark H Soonpaa; Jeffrey M Leiden; Richard L Moss
Length dependence of Ca2+ sensitivity of tension in mouse cardiac myocytes expressing skeletal troponin C.
The Journal of physiology 1995;483 ( Pt 1)():131-9.
1995: M W Chang; E Barr; J Seltzer; Y Q Jiang; Gary Nabel; Elizabeth G Nabel; Michael S Parmacek; Jeffrey M Leiden
Cytostatic gene therapy for vascular proliferative disorders with a constitutively active form of the retinoblastoma gene product.
Science (New York, N.Y.) 1995;267(5197):518-22.
1995: Hon S Ip; David B Wilson; Markku Heikinheimo; Jeffrey M Leiden; Michael S Parmacek
The GATA-4 transcription factor transactivates the cardiac-specific troponin C promoter-enhancer in non-muscle cells.
Advances in experimental medicine and biology 1995;382():117-24.
1995: M W Chang; T Ohno; David F Gordon; Min Min Lu; Gary Nabel; Elizabeth G Nabel; Jeffrey M Leiden
Adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene inhibits vascular smooth muscle cell proliferation and neointima formation following balloon angioplasty of the rat carotid artery.
Molecular medicine (Cambridge, Mass.) 1995;1(2):172-81.
1994: S K Tripathy; E Goldwasser; Min Min Lu; E Barr; Jeffrey M Leiden
Stable delivery of physiologic levels of recombinant erythropoietin to the systemic circulation by intramuscular injection of replication-defective adenovirus.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(24):11557-61.
1994: Hon S Ip; David B Wilson; Markku Heikinheimo; Z Tang; C N Ting; M Celeste Simon; Jeffrey M Leiden; Michael S Parmacek
The GATA-4 transcription factor transactivates the cardiac muscle-specific troponin C promoter-enhancer in nonmuscle cells.
Molecular and cellular biology 1994;14(11):7517-26.
1994: X Mao; Susan Miesfeldt; H Yang; Jeffrey M Leiden; Craig Thompson
The FLI-1 and chimeric EWS-FLI-1 oncoproteins display similar DNA binding specificities.
The Journal of biological chemistry 1994;269(27):18216-22.
1994: Michael S Parmacek; Hon S Ip; F Jung; T Shen; J F Martin; A J Vora; E N Olson; Jeffrey M Leiden
A novel myogenic regulatory circuit controls slow/cardiac troponin C gene transcription in skeletal muscle.
Molecular and cellular biology 1994;14(3):1870-85.
1994: C Y Wang; A G Bassuk; Lawrence Boise; Craig Thompson; R Bravo; Jeffrey M Leiden
Activation of the granulocyte-macrophage colony-stimulating factor promoter in T cells requires cooperative binding of Elf-1 and AP-1 transcription factors.
Molecular and cellular biology 1994;14(2):1153-9.
1994: E Barr; J Carroll; A M Kalynych; S K Tripathy; K Kozarsky; J M Wilson; Jeffrey M Leiden
Efficient catheter-mediated gene transfer into the heart using replication-defective adenovirus.
Gene therapy 1994;1(1):51-8.
1993: Joseph M Metzger; Michael S Parmacek; E Barr; K Pasyk; W I Lin; K L Cochrane; Loren J Field; Jeffrey M Leiden
Skeletal troponin C reduces contractile sensitivity to acidosis in cardiac myocytes from transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(19):9036-40.
1993: Susan Miesfeldt; S Kim; C A Hanson; P R Bohjanen; Jeffrey M Leiden; W M Crist; A J Carroll; Craig Thompson
DNA fragments of altered electrophoretic mobility in leukemia samples can arise from double-strand DNA breaks at nuclease hypersensitive sites of active genes.
Cancer genetics and cytogenetics 1993;68(1):34-41.
1993: C Y Wang; B Petryniak; Craig Thompson; William G Kaelin; Jeffrey M Leiden
Regulation of the Ets-related transcription factor Elf-1 by binding to the retinoblastoma protein.
Science (New York, N.Y.) 1993;260(5112):1330-5.
1993: Lawrence Boise; B Petryniak; X Mao; Carl H June; C Y Wang; T Lindsten; R Bravo; K Kovary; Jeffrey M Leiden; Craig Thompson
The NFAT-1 DNA binding complex in activated T cells contains Fra-1 and JunB.
Molecular and cellular biology 1993;13(3):1911-9.
1993: Jeffrey M Leiden
Transcriptional regulation of T cell receptor genes.
Annual review of immunology 1993;11():539-70.
1992: Laurence A Turka; Peter Linsley; H Lin; W Brady; Jeffrey M Leiden; R Q Wei; M L Gibson; X G Zheng; S Myrdal; David F Gordon
T-cell activation by the CD28 ligand B7 is required for cardiac allograft rejection in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(22):11102-5.
1992: Jeffrey M Leiden; C Y Wang; B Petryniak; David M Markovitz; Gary Nabel; Craig Thompson
A novel Ets-related transcription factor, Elf-1, binds to human immunodeficiency virus type 2 regulatory elements that are required for inducible trans activation in T cells.
Journal of virology 1992;66(10):5890-7.
1992: B A Karpinski; G D Morle; Jodi Huggenvik; Michael D Uhler; Jeffrey M Leiden
Molecular cloning of human CREB-2: an ATF/CREB transcription factor that can negatively regulate transcription from the cAMP response element.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(11):4820-4.
1992: Michael S Parmacek; A J Vora; T Shen; E Barr; F Jung; Jeffrey M Leiden
Identification and characterization of a cardiac-specific transcriptional regulatory element in the slow/cardiac troponin C gene.
Molecular and cellular biology 1992;12(5):1967-76.
1992: C Y Wang; B Petryniak; I C Ho; Craig Thompson; Jeffrey M Leiden
Evolutionarily conserved Ets family members display distinct DNA binding specificities.
The Journal of experimental medicine 1992;175(5):1391-9.
1991: E Barr; Jeffrey M Leiden
Systemic delivery of recombinant proteins by genetically modified myoblasts.
Science (New York, N.Y.) 1991;254(5037):1507-9.
1991: Michael S Parmacek; Jeffrey M Leiden
Structure, function, and regulation of troponin C.
Circulation 1991;84(3):991-1003.
1991: I C Ho; P Vorhees; N Marin; B K Oakley; S F Tsai; Stuart H Orkin; Jeffrey M Leiden
Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor alpha gene.
The EMBO journal 1991;10(5):1187-92.
1990: H Lin; M S Parmacek; G Morle; Steven F Bolling; Jeffrey M Leiden
Expression of recombinant genes in myocardium in vivo after direct injection of DNA.
Circulation 1990;82(6):2217-21.
1990: I C Ho; N K Bhat; L R Gottschalk; T Lindsten; Craig Thompson; TS Papas; Jeffrey M Leiden
Sequence-specific binding of human Ets-1 to the T cell receptor alpha gene enhancer.
Science (New York, N.Y.) 1990;250(4982):814-8.
1990: I C Ho; Jeffrey M Leiden
The T alpha 2 nuclear protein binding site from the human T cell receptor alpha enhancer functions as both a T cell-specific transcriptional activator and repressor.
The Journal of experimental medicine 1990;172(5):1443-9.
1990: L W Tjoelker; L M Carlson; K Lee; J Lahti; Wayne T McCormack; Jeffrey M Leiden; C L Chen; Max D Cooper; Craig Thompson
Evolutionary conservation of antigen recognition: the chicken T-cell receptor beta chain.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(20):7856-60.
1990: L R Gottschalk; Jeffrey M Leiden
Identification and functional characterization of the human T-cell receptor beta gene transcriptional enhancer: common nuclear proteins interact with the transcriptional regulatory elements of the T-cell receptor alpha and beta genes.
Molecular and cellular biology 1990;10(10):5486-95.
1990: Michael S Parmacek; A Resai Bengur; A J Vora; Jeffrey M Leiden
The structure and regulation of expression of the murine fast skeletal troponin C gene. Identification of a developmentally regulated, muscle-specific transcriptional enhancer.
The Journal of biological chemistry 1990;265(26):15970-6.
1990: I C Ho; Jeffrey M Leiden
Regulation of the human T-cell receptor alpha gene enhancer: multiple ubiquitous and T-cell-specific nuclear proteins interact with four hypomethylated enhancer elements.
Molecular and cellular biology 1990;10(9):4720-7.
1989: I C Ho; L H Yang; G Morle; Jeffrey M Leiden
A T-cell-specific transcriptional enhancer element 3' of C alpha in the human T-cell receptor alpha locus.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(17):6714-8.
1989: Michael S Parmacek; Jeffrey M Leiden
Structure and expression of the murine slow/cardiac troponin C gene.
The Journal of biological chemistry 1989;264(22):13217-25.
1989: Jeffrey M Leiden; L H Yang; G D Morle; Carl H June; T Lindsten; Craig Thompson; B Karpinski
The 4F2 heavy chain gene: a molecular model of inducible gene expression in human T cells.
Journal of autoimmunity 1989;2 Suppl():67-79.
1989: B A Karpinski; L H Yang; P Cacheris; G D Morle; Jeffrey M Leiden
The first intron of the 4F2 heavy-chain gene contains a transcriptional enhancer element that binds multiple nuclear proteins.
Molecular and cellular biology 1989;9(6):2588-97.
1989: Carl H June; K M Jackson; J A Ledbetter; Jeffrey M Leiden; T Lindsten; Craig Thompson
Two distinct mechanisms of interleukin-2 gene expression in human T lymphocytes.
Journal of autoimmunity 1989;2 Suppl():55-65.
1989: Jeffrey M Leiden; B A Karpinski; L Gottschalk; J Kornbluth
Susceptibility to natural killer cell-mediated cytolysis is independent of the level of target cell class I HLA expression.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(6):2140-7.
1989: Michael S Parmacek; B A Karpinski; K M Gottesdiener; Craig Thompson; Jeffrey M Leiden
Structure, expression and regulation of the murine 4F2 heavy chain.
Nucleic acids research 1989;17(5):1915-31.
1989: Craig Thompson; T Lindsten; J A Ledbetter; Steven Kunkel; H A Young; Stephen G Emerson; Jeffrey M Leiden; Carl H June
CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(4):1333-7.
1988: T Lindsten; Carl H June; Craig Thompson; Jeffrey M Leiden
Regulation of 4F2 heavy-chain gene expression during normal human T-cell activation can be mediated by multiple distinct molecular mechanisms.
Molecular and cellular biology 1988;8(9):3820-6.
1988: K M Gottesdiener; B A Karpinski; T Lindsten; Jack L Strominger; N H Jones; Craig Thompson; Jeffrey M Leiden
Isolation and structural characterization of the human 4F2 heavy-chain gene, an inducible gene involved in T-lymphocyte activation.
Molecular and cellular biology 1988;8(9):3809-19.
1987: E Quackenbush; M Clabby; K M Gottesdiener; J Barbosa; N H Jones; J L Strominger; Samuel H Speck; Jeffrey M Leiden
Molecular cloning of complementary DNAs encoding the heavy chain of the human 4F2 cell-surface antigen: a type II membrane glycoprotein involved in normal and neoplastic cell growth.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(18):6526-30.