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Irene Leigh

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Anatomy

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Living Beings

Papillomaviridae

Procedures

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Amino Acid Sequence

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Publications

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Purdie Karin J; Harwood Catherine A; Gulati Abha; Chaplin Tracy; Lambert Sally R; Cerio Rino; Kelly Gavin P; Cazier Jean-Baptiste; Young Bryan D; Leigh Irene M; Proby Charlotte M
Single nucleotide polymorphism array analysis defines a specific genetic fingerprint for well-differentiated cutaneous SCCs.
Gibbon Karen L; Ekeowa-Anderson Arucha L; Leigh Irene M
External anogenital premalignant and malignant disease.
Wong Tracy; Gammon Luke; Liu Lu; Mellerio Jemima E; Dopping-Hepenstal Patricia J C; Pacy John; Elia George; Jeffery Rosemary; Leigh Irene M; Navsaria Harshad; McGrath John A
Potential of fibroblast cell therapy for recessive dystrophic epidermolysis bullosa.

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All Publications

2009: Purdie Karin J; Harwood Catherine A; Gulati Abha; Chaplin Tracy; Lambert Sally R; Cerio Rino; Kelly Gavin P; Cazier Jean-Baptiste; Young Bryan D; Leigh Irene M; Proby Charlotte M
Single nucleotide polymorphism array analysis defines a specific genetic fingerprint for well-differentiated cutaneous SCCs.
The Journal of investigative dermatology 2009;129(6):1562-8.
2009: Gibbon Karen L; Ekeowa-Anderson Arucha L; Leigh Irene M
External anogenital premalignant and malignant disease.
Cancer treatment and research 2009;146():279-98.
2008: Wong Tracy; Gammon Luke; Liu Lu; Mellerio Jemima E; Dopping-Hepenstal Patricia J C; Pacy John; Elia George; Jeffery Rosemary; Leigh Irene M; Navsaria Harshad; McGrath John A
Potential of fibroblast cell therapy for recessive dystrophic epidermolysis bullosa.
The Journal of investigative dermatology 2008;128(9):2179-89.
2008: Lalli Anand; Tilakaratne Wanninayake M; Ariyawardana Anura; Fitchett Caroline; Leigh Irene M; Hagi-Pavli Eleni; Cruchley Alan T; Parkinson E Kenneth; Teh Muy-Teck; Fortune Farida; Waseem Ahmad
An altered keratinocyte phenotype in oral submucous fibrosis: correlation of keratin K17 expression with disease severity.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2008;37(4):211-20.
2007: Pourreyron Celine; Cox Georgie; Mao Xin; Volz Andreas; Baksh Nuzhat; Wong Tracy; Fassihi Hiva; Arita Ken; O'Toole Edel A; Ocampo-Candiani Jorge; Chen Mei; Hart Ian R; Bruckner-Tuderman Leena; Salas-Alanis Julio C; McGrath John A; Leigh Irene M; South Andrew P
Patients with recessive dystrophic epidermolysis bullosa develop squamous-cell carcinoma regardless of type VII collagen expression.
The Journal of investigative dermatology 2007;127(10):2438-44.
2007: Myers Simon R; Leigh Irene M; Navsaria Harshad
Epidermal repair results from activation of follicular and epidermal progenitor keratinocytes mediated by a growth factor cascade.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2007;15(5):693-701.
2007: Akgül Baki; Ghali Lucy; Davies Derek; Pfister Herbert; Leigh Irene M; Storey Alan
HPV8 early genes modulate differentiation and cell cycle of primary human adult keratinocytes.
Experimental dermatology 2007;16(7):590-9.
2007: Purdie Karin J; Lambert Sally R; Teh Muy-Teck; Chaplin Tracy; Molloy Gael; Raghavan Manoj; Kelsell David P; Leigh Irene M; Harwood Catherine A; Proby Charlotte M; Young Bryan D
Allelic imbalances and microdeletions affecting the PTPRD gene in cutaneous squamous cell carcinomas detected using single nucleotide polymorphism microarray analysis.
Genes, chromosomes & cancer 2007;46(7):661-9.
2007: Ekeowa-Anderson A L; Harwood C A; Perrett C M; Sahota A; Annan H; Ran H; Leigh I M; Gibbon K L
Vulval intraepithelial neoplasia and periungual Bowen's disease concordant for mucosal (HPV-34) and epidermodysplasia verruciformis (HPV-21) human papillomavirus types.
Clinical and experimental dermatology 2007;32(3):304-7.
2007: Perrett C M; McGregor J M; Warwick J; Karran P; Leigh I M; Proby C M; Harwood C A
Treatment of post-transplant premalignant skin disease: a randomized intrapatient comparative study of 5-fluorouracil cream and topical photodynamic therapy.
The British journal of dermatology 2007;156(2):320-8.
2007: Teh Muy-Teck; Blaydon Diana; Ghali Lucy R; Briggs Victoria; Edmunds Scott; Pantazi Eleni; Barnes Michael R; Leigh Irene M; Kelsell David P; Philpott Michael P
Role for WNT16B in human epidermal keratinocyte proliferation and differentiation.
Journal of cell science 2007;120(Pt 2):330-9.
2006: Price Richard D; Das-Gupta Victoria; Leigh Irene M; Navsaria Harshad A
A comparison of tissue-engineered hyaluronic acid dermal matrices in a human wound model.
Tissue engineering 2006;12(10):2985-95.
2006: Norgett Elizabeth E; Lucke Tom W; Bowers Bill; Munro Colin S; Leigh Irene M; Kelsell David P
Early death from cardiomyopathy in a family with autosomal dominant striate palmoplantar keratoderma and woolly hair associated with a novel insertion mutation in desmoplakin.
The Journal of investigative dermatology 2006;126(7):1651-4.
2006: Green J; Ikram M; Vyas J; Patel N; Proby C M; Ghali L; Leigh I M; O'Toole E A; Storey A
Overexpression of the Axl tyrosine kinase receptor in cutaneous SCC-derived cell lines and tumours.
British journal of cancer 2006;94(10):1446-51.
2006: Uzumcu A; Norgett E E; Dindar A; Uyguner O; Nisli K; Kayserili H; Sahin S E; Dupont E; Severs N J; Leigh I M; Yuksel-Apak M; Kelsell D P; Wollnik B
Loss of desmoplakin isoform I causes early onset cardiomyopathy and heart failure in a Naxos-like syndrome.
Journal of medical genetics 2006;43(2):e5.
2006: Harwood Catherine A; Proby Charlotte M; McGregor Jane M; Sheaff Michael T; Leigh Irene M; Cerio Rino
Clinicopathologic features of skin cancer in organ transplant recipients: a retrospective case-control series.
Journal of the American Academy of Dermatology 2006;54(2):290-300.
2005: Common John E A; O'Toole Edel A; Leigh Irene M; Thomas Anna; Griffiths William A D; Venning Vanessa; Grabczynska Sophie; Peris Zdravko; Kansky Aleksej; Kelsell David P
Clinical and genetic heterogeneity of erythrokeratoderma variabilis.
The Journal of investigative dermatology 2005;125(5):920-7.
2005: Leigh Irene M
Genetic diseases affecting the epidermis.
Experimental dermatology 2005;14(10):792-3.
2005: Kelsell David P; Norgett Elizabeth E; Unsworth Harriet; Teh Muy-Teck; Cullup Thomas; Mein Charles A; Dopping-Hepenstal Patricia J; Dale Beverly A; Tadini Gianluca; Fleckman Philip; Stephens Karen G; Sybert Virginia P; Mallory Susan B; North Bernard V; Witt David R; Sprecher Eli; Taylor Aileen E M; Ilchyshyn Andrew; Kennedy Cameron T; Goodyear Helen; Moss Celia; Paige David; Harper John I; Young Bryan D; Leigh Irene M; Eady Robin A J; O'Toole Edel A
Mutations in ABCA12 underlie the severe congenital skin disease harlequin ichthyosis.
American journal of human genetics 2005;76(5):794-803.
2005: Harwood Catherine A; Leedham-Green Mary; Leigh Irene M; Proby Charlotte M
Low-dose retinoids in the prevention of cutaneous squamous cell carcinomas in organ transplant recipients: a 16-year retrospective study.
Archives of dermatology 2005;141(4):456-64.
2005: Harwood C A; Perrett C M; Brown V L; Leigh I M; McGregor J M; Proby C M
Imiquimod cream 5% for recalcitrant cutaneous warts in immunosuppressed individuals.
The British journal of dermatology 2005;152(1):122-9.
2005: Price Richard D; Myers Simon; Leigh Irene M; Navsaria Harshad A
The role of hyaluronic acid in wound healing: assessment of clinical evidence.
American journal of clinical dermatology 2005;6(6):393-402.
2004: Norgett E E; Wolf F; Balme B; Leigh I M; Perrot H; Kelsell D P; Haftek M
Hereditary 'white nails': a genetic and structural study.
The British journal of dermatology 2004;151(1):65-72.
2004: Harwood C A; Surentheran T; Sasieni P; Proby C M; Bordea C; Leigh I M; Wojnarowska F; Breuer J; McGregor J M
Increased risk of skin cancer associated with the presence of epidermodysplasia verruciformis human papillomavirus types in normal skin.
The British journal of dermatology 2004;150(5):949-57.
2004: Price Richard D; Das-Gupta Victoria; Harris Paul A; Leigh Irene M; Navsaria Harshad A
The role of allogenic fibroblasts in an acute wound healing model.
Plastic and reconstructive surgery 2004;113(6):1719-29.
2004: Langan Joanne E; Cole Charlotte G; Huckle Elisabeth J; Byrne Shaun; McRonald Fiona E; Rowbottom Lynn; Ellis Anthony; Shaw Joan M; Leigh Irene M; Kelsell David P; Dunham Ian; Field John K; Risk Janet M
Novel microsatellite markers and single nucleotide polymorphisms refine the tylosis with oesophageal cancer (TOC) minimal region on 17q25 to 42.5 kb: sequencing does not identify the causative gene.
Human genetics 2004;114(6):534-40.
2004: Ghali Lucy; Wong Soon-Tee; Tidman Nick; Quinn Anthony; Philpott Michael P; Leigh Irene M
Epidermal and hair follicle progenitor cells express melanoma-associated chondroitin sulfate proteoglycan core protein.
The Journal of investigative dermatology 2004;122(2):433-42.
2004: Waseem Ahmad; Karsten Uwe; Leigh Irene M; Purkis Patricia; Waseem Naushin H; Lane E Birgitte
Conformational changes in the rod domain of human keratin 8 following heterotypic association with keratin 18 and its implication for filament stability.
Biochemistry 2004;43(5):1283-95.
2003: Bowen Sharn L; Bloor Balvinder K; Leigh Irene M; Waseem Ahmad
Adducin expression in cutaneous and oral lesions: alpha- and beta-adducin transcripts down-regulate with keratinocyte differentiation in stratified epithelia.
The Journal of pathology 2003;201(1):119-26.
2003: South Andrew P; Wan Hong; Stone Michael G; Dopping-Hepenstal Patricia J C; Purkis Patricia E; Marshall John F; Leigh Irene M; Eady Robin A J; Hart Ian R; McGrath John A
Lack of plakophilin 1 increases keratinocyte migration and reduces desmosome stability.
Journal of cell science 2003;116(Pt 16):3303-14.
2003: Common John E A; Di Wei-Li; Davies Derek; Galvin Helen; Leigh Irene M; O'Toole Edel A; Kelsell David P
Cellular mechanisms of mutant connexins in skin disease and hearing loss.
Cell communication & adhesion 2003;10(4-6):347-51.
2003: Morley S M; D'Alessandro M; Sexton C; Rugg E L; Navsaria H; Shemanko C S; Huber M; Hohl D; Heagerty A I; Leigh I M; Lane E B
Generation and characterization of epidermolysis bullosa simplex cell lines: scratch assays show faster migration with disruptive keratin mutations.
The British journal of dermatology 2003;149(1):46-58.
2003: Bloor Balvinder K; Tidman Nicholas; Leigh Irene M; Odell Edward; Dogan Bilal; Wollina Uwe; Ghali Lucy; Waseem Ahmad
Expression of keratin K2e in cutaneous and oral lesions: association with keratinocyte activation, proliferation, and keratinization.
The American journal of pathology 2003;162(3):963-75.
2003: Eckl Katja Martina; Stevens Howard P; Lestringant Gilles G; Westenberger-Treumann Margaretha; Traupe Heiko; Hinz Britta; Frossard Philippe M; Stadler Rudolf; Leigh Irene M; Nürnberg Peter; Reis André; Hennies Hans Christian
Mal de Meleda (MDM) caused by mutations in the gene for SLURP-1 in patients from Germany, Turkey, Palestine, and the United Arab Emirates.
Human genetics 2003;112(1):50-6.
2002: Common John E A; Becker David; Di Wei-Li; Leigh Irene M; O'Toole Edel A; Kelsell David P
Functional studies of human skin disease- and deafness-associated connexin 30 mutations.
Biochemical and biophysical research communications 2002;298(5):651-6.
2002: Risk Janet M; Evans Kathryn E; Jones Joanne; Langan Joanne E; Rowbottom Lyn; McRonald Fiona E; Mills Helen S; Ellis Anthony; Shaw Joan M; Leigh Irene M; Kelsell David P; Field John K
Characterization of a 500 kb region on 17q25 and the exclusion of candidate genes as the familial Tylosis Oesophageal Cancer (TOC) locus.
Oncogene 2002;21(41):6395-402.
2002: Di Wei-Li; Monypenny James; Common John E A; Kennedy Cameron T C; Holland Katalin A; Leigh Irene M; Rugg Elizabeth L; Zicha Daniel; Kelsell David P
Defective trafficking and cell death is characteristic of skin disease-associated connexin 31 mutations.
Human molecular genetics 2002;11(17):2005-14.
2002: McGregor Jane M; Harwood Catherine A; Brooks Louise; Fisher Sheila A; Kelly Deirdre A; O'nions Jenny; Young Antony R; Surentheran Thiru; Breuer Judith; Millard Thomas P; Lewis Cathryn M; Leigh Irene M; Storey Alan; Crook Timothy
Relationship between p53 codon 72 polymorphism and susceptibility to sunburn and skin cancer.
The Journal of investigative dermatology 2002;119(1):84-90.
2002: Rugg E L; Common J E A; Wilgoss A; Stevens H P; Buchan J; Leigh I M; Kelsell D P
Diagnosis and confirmation of epidermolytic palmoplantar keratoderma by the identification of mutations in keratin 9 using denaturing high-performance liquid chromatography.
The British journal of dermatology 2002;146(6):952-7.
2001: Di W L; Rugg E L; Leigh I M; Kelsell D P
Multiple epidermal connexins are expressed in different keratinocyte subpopulations including connexin 31.
The Journal of investigative dermatology 2001;117(4):958-64.
2001: Virtanen M; Gedde-Dahl T; Mörk N J; Leigh I; Bowden P E; Vahlquist A
Phenotypic/genotypic correlations in patients with epidermolytic hyperkeratosis and the effects of retinoid therapy on keratin expression.
Acta dermato-venereologica 2001;81(3):163-70.
2001: Hatsell S J; Eady R A; Wennerstrand L; Dopping-Hepenstal P; Leigh I M; Munro C; Kelsell D P
Novel splice site mutation in keratin 1 underlies mild epidermolytic palmoplantar keratoderma in three kindreds.
The Journal of investigative dermatology 2001;116(4):606-9.
2001: Hunt D M; Rickman L; Whittock N V; Eady R A; Simrak D; Dopping-Hepenstal P J; Stevens H P; Armstrong D K; Hennies H C; Küster W; Hughes A E; Arnemann J; Leigh I M; McGrath J A; Kelsell D P; Buxton R S
Spectrum of dominant mutations in the desmosomal cadherin desmoglein 1, causing the skin disease striate palmoplantar keratoderma.
European journal of human genetics : EJHG 2001;9(3):197-203.
2001: Fear M W; Hatsell S J; Leigh I M; Kelsell D P
Whats new in genodermatoses?
The Keio journal of medicine 2001;50(1):35-8.
2001: Ola A; Waga S; Ellison V; Stillman B; McGurk M; Leigh I M; Waseem N H; Waseem A
Human-Saccharomyces cerevisiae proliferating cell nuclear antigen hybrids: oligomeric structure and functional characterization using in vitro DNA replication.
The Journal of biological chemistry 2001;276(13):10168-77.
2000: Popp S; Waltering S; Holtgreve-Grez H; Jauch A; Proby C; Leigh I M; Boukamp P
Genetic characterization of a human skin carcinoma progression model: from primary tumor to metastasis.
The Journal of investigative dermatology 2000;115(6):1095-103.
2000: Magin T M; Kaiser H W; Leitgeb S; Grund C; Leigh I M; Morley S M; Lane E B
Supplementation of a mutant keratin by stable expression of desmin in cultured human EBS keratinocytes.
Journal of cell science 2000;113 Pt 23():4231-9.
2000: Norgett E E; Hatsell S J; Carvajal-Huerta L; Cabezas J C; Common J; Purkis P E; Whittock N; Leigh I M; Stevens H P; Kelsell D P
Recessive mutation in desmoplakin disrupts desmoplakin-intermediate filament interactions and causes dilated cardiomyopathy, woolly hair and keratoderma.
Human molecular genetics 2000;9(18):2761-6.
2000: Harwood C A; Surentheran T; McGregor J M; Spink P J; Leigh I M; Breuer J; Proby C M
Human papillomavirus infection and non-melanoma skin cancer in immunosuppressed and immunocompetent individuals.
Journal of medical virology 2000;61(3):289-97.
2000: Kelsell D P; Wilgoss A L; Richard G; Stevens H P; Munro C S; Leigh I M
Connexin mutations associated with palmoplantar keratoderma and profound deafness in a single family.
European journal of human genetics : EJHG 2000;8(6):469-72.
2000: Proby C M; Purdie K J; Sexton C J; Purkis P; Navsaria H A; Stables J N; Leigh I M
Spontaneous keratinocyte cell lines representing early and advanced stages of malignant transformation of the epidermis.
Experimental dermatology 2000;9(2):104-17.
2000: Nievers M G; Kuikman I; Geerts D; Leigh I M; Sonnenberg A
Formation of hemidesmosome-like structures in the absence of ligand binding by the (alpha)6(beta)4 integrin requires binding of HD1/plectin to the cytoplasmic domain of the (beta)4 integrin subunit.
Journal of cell science 2000;113 ( Pt 6)():963-73.
2000: Kelsell D P; Wilgoss A L; Richard G; Stevens H P; Munro C S; Leigh I M
Connexin mutations associated with palmoplantar keratoderma and profound deafness in a single family.
European journal of human genetics : EJHG 2000;8(2):141-4.
2000: De Berker D; Wojnarowska F; Sviland L; Westgate G E; Dawber R P; Leigh I M
Keratin expression in the normal nail unit: markers of regional differentiation.
The British journal of dermatology 2000;142(1):89-96.
2000: Talas U; Dunlop J; Khalaf S; Leigh I M; Kelsell D P
Human elastase 1: evidence for expression in the skin and the identification of a frequent frameshift polymorphism.
The Journal of investigative dermatology 2000;114(1):165-70.
1999: Wilgoss A; Leigh I M; Barnes M R; Dopping-Hepenstal P; Eady R A; Walter J M; Kennedy C T; Kelsell D P
Identification of a novel mutation R42P in the gap junction protein beta-3 associated with autosomal dominant erythrokeratoderma variabilis.
The Journal of investigative dermatology 1999;113(6):1119-22.
1999: Harwood C A; Spink P J; Surentheran T; Leigh I M; de Villiers E M; McGregor J M; Proby C M; Breuer J
Degenerate and nested PCR: a highly sensitive and specific method for detection of human papillomavirus infection in cutaneous warts.
Journal of clinical microbiology 1999;37(11):3545-55.
1999: Kelsell D P; Stevens H P; Purkis P E; Talas U; Rustin M H; Leigh I M
Fine genetic mapping of diffuse non-epidermolytic palmoplantar keratoderma to chromosome 12q11-q13: exclusion of the mapped type II keratins.
Experimental dermatology 1999;8(5):388-91.
1999: Geerts D; Fontao L; Nievers M G; Schaapveld R Q; Purkis P E; Wheeler G N; Lane E B; Leigh I M; Sonnenberg A
Binding of integrin alpha6beta4 to plectin prevents plectin association with F-actin but does not interfere with intermediate filament binding.
The Journal of cell biology 1999;147(2):417-34.
1999: Purdie K J; Pennington J; Proby C M; Khalaf S; de Villiers E M; Leigh I M; Storey A
The promoter of a novel human papillomavirus (HPV77) associated with skin cancer displays UV responsiveness, which is mediated through a consensus p53 binding sequence.
The EMBO journal 1999;18(19):5359-69.
1999: Leigh I M; Buchanan J A; Harwood C A; Cerio R; Storey A
Role of human papillomaviruses in cutaneous and oral manifestations of immunosuppression.
Journal of acquired immune deficiency syndromes (1999) 1999;21 Suppl 1():S49-57.
1999: Risk J M; Ruhrberg C; Hennies H; Mills H S; Di Colandrea T; Evans K E; Ellis A; Watt F M; Bishop D T; Spurr N K; Stevens H P; Leigh I M; Reis A; Kelsell D P; Field J K
Envoplakin, a possible candidate gene for focal NEPPK/esophageal cancer (TOC): the integration of genetic and physical maps of the TOC region on 17q25.
Genomics 1999;59(2):234-42.
1999: Rickman L; Simrak D; Stevens H P; Hunt D M; King I A; Bryant S P; Eady R A; Leigh I M; Arnemann J; Magee A I; Kelsell D P; Buxton R S
N-terminal deletion in a desmosomal cadherin causes the autosomal dominant skin disease striate palmoplantar keratoderma.
Human molecular genetics 1999;8(6):971-6.
1999: McLean W H; Morley S M; Higgins C; Bowden P E; White M; Leigh I M; Lane E B
Novel and recurrent mutations in keratin 10 causing bullous congenital ichthyosiform erythroderma.
Experimental dermatology 1999;8(2):120-3.
1999: Waseem A; Dogan B; Tidman N; Alam Y; Purkis P; Jackson S; Lalli A; Machesney M; Leigh I M
Keratin 15 expression in stratified epithelia: downregulation in activated keratinocytes.
The Journal of investigative dermatology 1999;112(3):362-9.
1999: McGrath J A; Hoeger P H; Christiano A M; McMillan J R; Mellerio J E; Ashton G H; Dopping-Hepenstal P J; Lake B D; Leigh I M; Harper J I; Eady R A
Skin fragility and hypohidrotic ectodermal dysplasia resulting from ablation of plakophilin 1.
The British journal of dermatology 1999;140(2):297-307.
1999: Armstrong D K; McKenna K E; Purkis P E; Green K J; Eady R A; Leigh I M; Hughes A E
Haploinsufficiency of desmoplakin causes a striate subtype of palmoplantar keratoderma.
Human molecular genetics 1999;8(1):143-8.
1998: Winter H; Langbein L; Praetzel S; Jacobs M; Rogers M A; Leigh I M; Tidman N; Schweizer J
A novel human type II cytokeratin, K6hf, specifically expressed in the companion layer of the hair follicle.
The Journal of investigative dermatology 1998;111(6):955-62.
1998: Green J; Leigh I M; Poulsom R; Quinn A G
Basal cell carcinoma development is associated with induction of the expression of the transcription factor Gli-1.
The British journal of dermatology 1998;139(5):911-5.
1998: Swensson O; Langbein L; McMillan J R; Stevens H P; Leigh I M; McLean W H; Lane E B; Eady R A
Specialized keratin expression pattern in human ridged skin as an adaptation to high physical stress.
The British journal of dermatology 1998;139(5):767-75.
1998: Surentheran T; Harwood C A; Spink P J; Sinclair A L; Leigh I M; Proby C M; McGregor J M; Breuer J
Detection and typing of human papillomaviruses in mucosal and cutaneous biopsies from immunosuppressed and immunocompetent patients and patients with epidermodysplasia verruciformis: a unified diagnostic approach.
Journal of clinical pathology 1998;51(8):606-10.
1998: Waseem A; Alam Y; Dogan B; White K N; Leigh I M; Waseem N H
Isolation, sequence and expression of the gene encoding human keratin 13.
Gene 1998;215(2):269-79.
1998: Harwood C A; Spink P J; Surentheran T; Leigh I M; Hawke J L; Proby C M; Breuer J; McGregor J M
Detection of human papillomavirus DNA in PUVA-associated non-melanoma skin cancers.
The Journal of investigative dermatology 1998;111(1):123-7.
1998: Storey A; Thomas M; Kalita A; Harwood C; Gardiol D; Mantovani F; Breuer J; Leigh I M; Matlashewski G; Banks L
Role of a p53 polymorphism in the development of human papillomavirus-associated cancer.
Nature 1998;393(6682):229-34.
1998: Machesney M; Tidman N; Waseem A; Kirby L; Leigh I
Activated keratinocytes in the epidermis of hypertrophic scars.
The American journal of pathology 1998;152(5):1133-41.
1997: Laass M W; Hennies H C; Preis S; Stevens H P; Jung M; Leigh I M; Wienker T F; Reis A
Localisation of a gene for Papillon-Lefèvre syndrome to chromosome 11q14-q21 by homozygosity mapping.
Human genetics 1997;101(3):376-82.
1997: McGrath J A; McMillan J R; Shemanko C S; Runswick S K; Leigh I M; Lane E B; Garrod D R; Eady R A
Mutations in the plakophilin 1 gene result in ectodermal dysplasia/skin fragility syndrome.
Nature genetics 1997;17(2):240-4.
1997: Winter H; Rogers M A; Langbein L; Stevens H P; Leigh I M; Labrèze C; Roul S; Taieb A; Krieg T; Schweizer J
Mutations in the hair cortex keratin hHb6 cause the inherited hair disease monilethrix.
Nature genetics 1997;16(4):372-4.
1997: Westgate G E; Tidman N; De Berker D; Blount M A; Philpott M P; Leigh I M
Characterization of LHTric-1, a new monospecific monoclonal antibody to the trichocyte keratin Ha1.
The British journal of dermatology 1997;137(1):24-30.
1997: Kelsell D P; Dunlop J; Stevens H P; Lench N J; Liang J N; Parry G; Mueller R F; Leigh I M
Connexin 26 mutations in hereditary non-syndromic sensorineural deafness.
Nature 1997;387(6628):80-3.
1997: Harris A J; Purdie K; Leigh I M; Proby C; Burge S
A novel human papillomavirus identified in epidermodysplasia verruciformis.
The British journal of dermatology 1997;136(4):587-91.
1997: Smith F J; Corden L D; Rugg E L; Ratnavel R; Leigh I M; Moss C; Tidman M J; Hohl D; Huber M; Kunkeler L; Munro C S; Lane E B; McLean W H
Missense mutations in keratin 17 cause either pachyonychia congenita type 2 or a phenotype resembling steatocystoma multiplex.
The Journal of investigative dermatology 1997;108(2):220-3.
1996: Smith F J; Eady R A; Leigh I M; McMillan J R; Rugg E L; Kelsell D P; Bryant S P; Spurr N K; Geddes J F; Kirtschig G; Milana G; de Bono A G; Owaribe K; Wiche G; Pulkkinen L; Uitto J; McLean W H; Lane E B
Plectin deficiency results in muscular dystrophy with epidermolysis bullosa.
Nature genetics 1996;13(4):450-7.
1996: McLean W H; Pulkkinen L; Smith F J; Rugg E L; Lane E B; Bullrich F; Burgeson R E; Amano S; Hudson D L; Owaribe K; McGrath J A; McMillan J R; Eady R A; Leigh I M; Christiano A M; Uitto J
Loss of plectin causes epidermolysis bullosa with muscular dystrophy: cDNA cloning and genomic organization.
Genes & development 1996;10(14):1724-35.
1996: Kelsell D P; Risk J M; Leigh I M; Stevens H P; Ellis A; Hennies H C; Reis A; Weissenbach J; Bishop D T; Spurr N K; Field J K
Close mapping of the focal non-epidermolytic palmoplantar keratoderma (PPK) locus associated with oesophageal cancer (TOC).
Human molecular genetics 1996;5(6):857-60.
1996: Stevens H P; Kelsell D P; Bryant S P; Bishop D T; Spurr N K; Weissenbach J; Marger D; Marger R S; Leigh I M
Linkage of an American pedigree with palmoplantar keratoderma and malignancy (palmoplantar ectodermal dysplasia type III) to 17q24. Literature survey and proposed updated classification of the keratodermas.
Archives of dermatology 1996;132(6):640-51.
1996: Shamanin V; zur Hausen H; Lavergne D; Proby C M; Leigh I M; Neumann C; Hamm H; Goos M; Haustein U F; Jung E G; Plewig G; Wolff H; de Villiers E M
Human papillomavirus infections in nonmelanoma skin cancers from renal transplant recipients and nonimmunosuppressed patients.
Journal of the National Cancer Institute 1996;88(12):802-11.
1996: Stevens H P; Kelsell D P; Leigh I M; Ostlere L S; MacDermot K D; Rustin M H
Punctate palmoplantar keratoderma and malignancy in a four-generation family.
The British journal of dermatology 1996;134(4):720-6.
1996: Stevens H P; Kelsell D P; Bryant S P; Bishop D T; Dawber R P; Spurr N K; Leigh I M
Linkage of monilethrix to the trichocyte and epithelial keratin gene cluster on 12q11-q13.
The Journal of investigative dermatology 1996;106(4):795-7.
1996: Winter H; Rogers M A; Mahr B; Cremer M; Krieg T; Navsaria H A; Leigh I M; Schweizer J
The region coding for the helix termination motif and the adjacent intron 6 of the human type I hair keratin gene hHa2 contains three natural, closely spaced polymorphic sites.
The Journal of investigative dermatology 1996;106(3):544-8.
1996: Hughes B R; Morris C; Cunliffe W J; Leigh I M
Keratin expression in pilosebaceous epithelia in truncal skin of acne patients.
The British journal of dermatology 1996;134(2):247-56.
1996: McGregor J M; Proby C M; Leigh I M
Virus infection and cancer risk in transplant recipients.
Trends in microbiology 1996;4(1):2-3.
1995: Sexton C J; Williams A T; Topley P; Shaw R J; Lovegrove C; Leigh I; Stables J N
Development and characterization of a novel xenograft model permissive for human papillomavirus DNA amplification and late gene expression.
The Journal of general virology 1995;76 ( Pt 12)():3107-12.
1995: Glover M; Cerio R; Corbett M; Leigh I; Hanby A M
Cutaneous squamoproliferative lesions in renal transplant recipients. Differentiation from lesions in immunocompetent patients.
The American Journal of dermatopathology 1995;17(6):551-4.
1995: Kupsch J M; Tidman N; Bishop J A; McKay I; Leigh I; Crowe J S
Generation and selection of monoclonal antibodies, single-chain Fv and antibody fusion phage specific for human melanoma-associated antigens.
Melanoma research 1995;5(6):403-11.
1995: Myers S R; Navsaria H A; Brain A N; Purkis P E; Leigh I M
Epidermal differentiation and dermal changes in healing following treatment of surgical wounds with sheets of cultured allogeneic keratinocytes.
Journal of clinical pathology 1995;48(12):1087-92.
1995: Morley S M; Dundas S R; James J L; Gupta T; Brown R A; Sexton C J; Navsaria H A; Leigh I M; Lane E B
Temperature sensitivity of the keratin cytoskeleton and delayed spreading of keratinocyte lines derived from EBS patients.
Journal of cell science 1995;108 ( Pt 11)():3463-71.
1995: Bryan D; Sexton C J; Williams D; Leigh I M; McKay I A
Oral keratinocytes immortalized with the early region of human papillomavirus type 16 show elevated expression of interleukin 6, which acts as an autocrine growth factor for the derived T103C cell line.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1995;6(10):1245-50.
1995: Leigh I M; Navsaria H; Purkis P E; McKay I A; Bowden P E; Riddle P N
Keratins (K16 and K17) as markers of keratinocyte hyperproliferation in psoriasis in vivo and in vitro.
The British journal of dermatology 1995;133(4):501-11.
1995: Kelsell D P; Stevens H P; Ratnavel R; Bryant S P; Bishop D T; Leigh I M; Spurr N K
Genetic linkage studies in non-epidermolytic palmoplantar keratoderma: evidence for heterogeneity.
Human molecular genetics 1995;4(6):1021-5.
1995: King G N; Healy C M; Glover M T; Kwan J T; Williams D M; Leigh I M; Worthington H V; Thornhill M H
Increased prevalence of dysplastic and malignant lip lesions in renal-transplant recipients.
The New England journal of medicine 1995;332(16):1052-7.
1995: Navsaria H A; Myers S R; Leigh I M; McKay I A
Culturing skin in vitro for wound therapy.
Trends in biotechnology 1995;13(3):91-100.
1995: Gu X H; Terenghi G; Kangesu T; Navsaria H A; Springall D R; Leigh I M; Green C J; Polak J M
Regeneration pattern of blood vessels and nerves in cultured keratinocyte grafts assessed by confocal laser scanning microscopy.
The British journal of dermatology 1995;132(3):376-83.
1995: Williams A T; Sexton C J; Hanna N F; Leigh I M
Upregulation of integrin expression in benign vulvar warts.
The Journal of pathology 1995;175(3):311-7.
1995: Navsaria H A; Swensson O; Ratnavel R C; Shamsher M; McLean W H; Lane E B; Griffiths D; Eady R A; Leigh I M
Ultrastructural changes resulting from keratin-9 gene mutations in two families with epidermolytic palmoplantar keratoderma.
The Journal of investigative dermatology 1995;104(3):425-9.
1995: Tatnall F M; Schofield J K; Leigh I M
A double-blind, placebo-controlled trial of continuous acyclovir therapy in recurrent erythema multiforme.
The British journal of dermatology 1995;132(2):267-70.
1995: Leigh I M; Glover M T
Skin cancer and warts in immunosuppressed renal transplant recipients.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 1995;139():69-86.
1994: King G N; Healy C M; Glover M T; Kwan J T; Williams D M; Leigh I M; Thornhill M H
Prevalence and risk factors associated with leukoplakia, hairy leukoplakia, erythematous candidiasis, and gingival hyperplasia in renal transplant recipients.
Oral surgery, oral medicine, and oral pathology 1994;78(6):718-26.
1994: McKay I A; Winyard P; Leigh I M; Bustin S A
Nuclear transcription factors: potential targets for new modes of intervention in skin disease.
The British journal of dermatology 1994;131(5):591-7.
1994: Rugg E L; McLean W H; Lane E B; Pitera R; McMillan J R; Dopping-Hepenstal P J; Navsaria H A; Leigh I M; Eady R A
A functional "knockout" of human keratin 14.
Genes & development 1994;8(21):2563-73.
1994: Schofield J K; Tatnall F M; Brown J; McCloskey D; Navarrete C; Leigh I M
Recurrent erythema multiforme: tissue typing in a large series of patients.
The British journal of dermatology 1994;131(4):532-5.
1994: Shamanin V; Glover M; Rausch C; Proby C; Leigh I M; zur Hausen H; de Villiers E M
Specific types of human papillomavirus found in benign proliferations and carcinomas of the skin in immunosuppressed patients.
Cancer research 1994;54(17):4610-3.
1994: McLean W H; Morley S M; Lane E B; Eady R A; Griffiths W A; Paige D G; Harper J I; Higgins C; Leigh I M
Ichthyosis bullosa of Siemens--a disease involving keratin 2e.
The Journal of investigative dermatology 1994;103(3):277-81.
1994: Higgins C R; Tatnall F M; Leigh I M
Vesicular Langerhans cell histiocytosis--an uncommon variant.
Clinical and experimental dermatology 1994;19(4):350-2.
1994: Bustin S A; Nie X F; Barnard R C; Kumar V; Pascall J C; Brown K D; Leigh I M; Williams N S; McKay I A
Cloning and characterization of ERF-1, a human member of the Tis11 family of early-response genes.
DNA and cell biology 1994;13(5):449-59.
1994: Glover M T; Niranjan N; Kwan J T; Leigh I M
Non-melanoma skin cancer in renal transplant recipients: the extent of the problem and a strategy for management.
British journal of plastic surgery 1994;47(2):86-9.
1994: Williams A T; Sexton C J; Sinclair A L; Purdie K J; Thomas M S; Hanna N A; Goh B T; Williams D M; Leigh I M
Retention of low copy number human papillomavirus DNA in cultured cutaneous and mucosal wart keratinocytes.
The Journal of general virology 1994;75 ( Pt 3)():505-11.
1994: Higgins C R; Navsaria H; Stringer M; Spitz L; Leigh I M
Use of two stage keratinocyte-dermal grafting to treat the separation site in conjoined twins.
Journal of the Royal Society of Medicine 1994;87(2):108-9.
1994: Gu X H; Terenghi G; Purkis P E; Price D A; Leigh I M; Polak J M
Morphological changes of neural and vascular peptides in human skin suction blister injury.
The Journal of pathology 1994;172(1):61-72.
1994: McLean W H; Eady R A; Dopping-Hepenstal P J; McMillan J R; Leigh I M; Navsaria H A; Higgins C; Harper J I; Paige D G; Morley S M
Mutations in the rod 1A domain of keratins 1 and 10 in bullous congenital ichthyosiform erythroderma (BCIE).
The Journal of investigative dermatology 1994;102(1):24-30.
1994: Navsaria H A; Kangesu T; Manek S; Green C J; Leigh I M
An animal model to study the significance of dermis for grafting cultured keratinocytes on full thickness wounds.
Burns : journal of the International Society for Burn Injuries 1994;20 Suppl 1():S57-60.
1994: Ellis A; Field J K; Field E A; Friedmann P S; Fryer A; Howard P; Leigh I M; Risk J; Shaw J M; Whittaker J
Tylosis associated with carcinoma of the oesophagus and oral leukoplakia in a large Liverpool family--a review of six generations.
European journal of cancer. Part B, Oral oncology 1994;30B(2):102-12.
1993: Proby C M; Churchill L; Purkis P E; Glover M T; Sexton C J; Leigh I M
Keratin 17 expression as a marker for epithelial transformation in viral warts.
The American journal of pathology 1993;143(6):1667-78.
1993: Purdie K J; Sexton C J; Proby C M; Glover M T; Williams A T; Stables J N; Leigh I M
Malignant transformation of cutaneous lesions in renal allograft patients: a role for human papillomavirus.
Cancer research 1993;53(21):5328-33.
1993: Rugg E L; Morley S M; Smith F J; Boxer M; Tidman M J; Navsaria H; Leigh I M; Lane E B
Missing links: Weber-Cockayne keratin mutations implicate the L12 linker domain in effective cytoskeleton function.
Nature genetics 1993;5(3):294-300.
1993: Volyanik E V; Dalley A; McKay I A; Leigh I; Williams N S; Bustin S A
Synthesis of preparative amounts of biologically active interleukin-6 using a continuous-flow cell-free translation system.
Analytical biochemistry 1993;214(1):289-94.
1993: McGrath J A; Schofield O M; Ishida-Yamamoto A; O'Grady A; Mayou B J; Navsaria H; Leigh I M; Eady R A
Cultured keratinocyte allografts and wound healing in severe recessive dystrophic epidermolysis bullosa.
Journal of the American Academy of Dermatology 1993;29(3):407-19.
1993: Leigh I M; Purkis P E; Whitehead P; Lane E B
Monospecific monoclonal antibodies to keratin 1 carboxy terminal (synthetic peptide) and to keratin 10 as markers of epidermal differentiation.
The British journal of dermatology 1993;129(2):110-9.
1993: Kangesu T; Navsaria H A; Manek S; Fryer P R; Leigh I M; Green C J
Kerato-dermal grafts: the importance of dermis for the in vivo growth of cultured keratinocytes.
British journal of plastic surgery 1993;46(5):401-9.
1993: Kangesu T; Navsaria H A; Manek S; Shurey C B; Jones C R; Fryer P R; Leigh I M; Green C J
A porcine model using skin graft chambers for studies on cultured keratinocytes.
British journal of plastic surgery 1993;46(5):393-400.
1993: Carver N; Navsaria H A; Fryer P; Green C J; Leigh I M
Restoration of basement membrane structure in pigs following keratinocyte autografting.
British journal of plastic surgery 1993;46(5):384-92.
1993: Schofield J K; Tatnall F M; Leigh I M
Recurrent erythema multiforme: clinical features and treatment in a large series of patients.
The British journal of dermatology 1993;128(5):542-5.
1993: Carver N; Navsaria H A; Green C J; Leigh I M
The effect of backing materials on keratinocyte autograft take.
British journal of plastic surgery 1993;46(3):228-34.
1993: McGrath J A; Ishida-Yamamoto A; O'Grady A; Leigh I M; Eady R A
Structural variations in anchoring fibrils in dystrophic epidermolysis bullosa: correlation with type VII collagen expression.
The Journal of investigative dermatology 1993;100(4):366-72.
1993: Sexton C J; Proby C M; Banks L; Stables J N; Powell K; Navsaria H; Leigh I M
Characterization of factors involved in human papillomavirus type 16-mediated immortalization of oral keratinocytes.
The Journal of general virology 1993;74 ( Pt 4)():755-61.
1993: King I A; Tabiowo A; Purkis P; Leigh I; Magee A I
Expression of distinct desmocollin isoforms in human epidermis.
The Journal of investigative dermatology 1993;100(4):373-9.
1993: Glover M T; Bodmer J; Bodmer W; Kennedy L J; Brown J; Navarrete C; Kwan J T; Leigh I M
HLA antigen frequencies in renal transplant recipients and non-immunosuppressed patients with non-melanoma skin cancer.
European journal of cancer (Oxford, England : 1990) 1993;29A(4):520-4.
1993: Higgins C R; Schofield J K; Tatnall F M; Leigh I M
Natural history, management and complications of herpes labialis.
Journal of medical virology 1993;Suppl 1():22-6.
1993: Leigh I M; Purkis P E; Markey A; Collins P; Neill S; Proby C; Glover M; Lane E B
Keratinocyte alterations in skin tumour development.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 1993;128():179-91.
1992: Sexton C J; Navsaria H A; Leigh I M; Powell K
Replication of varicella zoster virus in primary human keratinocytes.
Journal of medical virology 1992;38(4):260-4.
1992: Glover M; Leigh I
Dermatomyositis pemphigoides: a case with coexistent dermatomyositis and bullous pemphigoid.
Journal of the American Academy of Dermatology 1992;27(5 Pt 2):849-52.
1992: Ishida-Yamamoto A; McGrath J A; Judge M R; Leigh I M; Lane E B; Eady R A
Selective involvement of keratins K1 and K10 in the cytoskeletal abnormality of epidermolytic hyperkeratosis (bullous congenital ichthyosiform erythroderma).
The Journal of investigative dermatology 1992;99(1):19-26.
1992: Lane E B; Rugg E L; Navsaria H; Leigh I M; Heagerty A H; Ishida-Yamamoto A; Eady R A
A mutation in the conserved helix termination peptide of keratin 5 in hereditary skin blistering.
Nature 1992;356(6366):244-6.
1992: Carver N; Leigh I M
Synthetic dressings.
International journal of dermatology 1992;31(1):10-8.
1991: Ishida-Yamamoto A; McGrath J A; Chapman S J; Leigh I M; Lane E B; Eady R A
Epidermolysis bullosa simplex (Dowling-Meara type) is a genetic disease characterized by an abnormal keratin-filament network involving keratins K5 and K14.
The Journal of investigative dermatology 1991;97(6):959-68.
1991: Carver N; Navsaria H A; Green C J; Leigh I M
Acute rejection of cultured keratinocyte allografts in nonimmunosuppressed pigs.
Transplantation 1991;52(5):918-21.
1991: Markey A C; Lane E B; Churchill L J; MacDonald D M; Leigh I M
Expression of simple epithelial keratins 8 and 18 in epidermal neoplasia.
The Journal of investigative dermatology 1991;97(5):763-70.
1991: King I A; Tabiowo A; Fryer P R; Purkis P E; Leigh I
Basal cell glycoprotein in pig epidermis closely resembles the beta 1 subunit of the integrin family of cell adhesion molecules.
The Journal of investigative dermatology 1991;97(3):501-5.
1991: Carver N; Leigh I M
Keratinocyte grafts and skin equivalents.
International journal of dermatology 1991;30(8):540-51.
1991: Jassim A; Schofield O; Whitehead P; Purkis P; Heagerty A H; Sachs J A; Eady R A; Leigh I M
Detection of a novel basement membrane antigen by GDA-J/F3 anti-human sperm fibrous sheath monoclonal antibody.
The British journal of dermatology 1991;125(2):101-7.
1991: Markey A C; Tidman M J; Churchill L J; Aplin J D; Leigh I M; Purkis P; MacDonald D M
The epidermal basement membrane in basal cell carcinoma: an immunohistochemical study.
The British journal of dermatology 1991;125(1):21-6.
1991: Leigh I M; Navsaria H; Purkis P E; McKay I
Clinical practice and biological effects of keratinocyte grafting.
Annals of the Academy of Medicine, Singapore 1991;20(4):549-55.
1991: McKay I A; Leigh I M
Epidermal cytokines and their roles in cutaneous wound healing.
The British journal of dermatology 1991;124(6):513-8.
1991: Wright S; Navsaria H; Leigh I M
Idiopathic scrotal calcinosis is idiopathic.
Journal of the American Academy of Dermatology 1991;24(5 Pt 1):727-30.
1991: Tatnall F M; Leigh I M; Gibson J R
Assay of antiseptic agents in cell culture: conditions affecting cytotoxicity.
The Journal of hospital infection 1991;17(4):287-96.
1990: Kerr L A; Navsaria H A; Barker J N; Sakkas L I; Leigh I M; MacDonald D M; Welsh K I
Interferon-gamma activates co-ordinate transcription of HLA-DR, DQ, and DP genes in cultured keratinocytes and requires de novo protein synthesis.
The Journal of investigative dermatology 1990;95(6):653-6.
1990: Shimizu H; McDonald J N; Gunner D B; Black M M; Bhogal B; Leigh I M; Whitehead P C; Eady R A
Epidermolysis bullosa acquisita antigen and the carboxy terminus of type VII collagen have a common immunolocalization to anchoring fibrils and lamina densa of basement membrane.
The British journal of dermatology 1990;122(5):577-85.
1990: Iles R K; Purkis P E; Whitehead P C; Oliver R T; Leigh I; Chard T
Expression of beta human chorionic gonadotrophin by non-trophoblastic non-endocrine 'normal' and malignant epithelial cells.
British journal of cancer 1990;61(5):663-6.
1990: Tatnall F M; Leigh I M; Gibson J R
Comparative study of antiseptic toxicity on basal keratinocytes, transformed human keratinocytes and fibroblasts.
Skin pharmacology : the official journal of the Skin Pharmacology Society 1990;3(3):157-63.
1989: Tatnall F M; Whitehead P C; Black M M; Wojnarowska F; Leigh I M
Identification of the epidermolysis bullosa acquisita antigen by LH 7.2 monoclonal antibody: use in diagnosis.
The British journal of dermatology 1989;120(4):533-9.
1989: Brain A; Purkis P; Coates P; Hackett M; Navsaria H; Leigh I
Survival of cultured allogeneic keratinocytes transplanted to deep dermal bed assessed with probe specific for Y chromosome.
BMJ (Clinical research ed.) 1989;298(6678):917-9.
1988: Barker J N; Navsaria H A; Leigh I M; MacDonald D M
Gamma-interferon induced human keratinocyte HLA-DR synthesis: the role of dermal activated T lymphocytes.
The British journal of dermatology 1988;119(5):567-72.
1988: Leigh I M
Management of non-genital herpes simplex virus infections in immunocompetent patients.
The American journal of medicine 1988;85(2A):34-8.
1988: Leigh I M; Eady R A; Heagerty A H; Purkis P E; Whitehead P A; Burgeson R E
Type VII collagen is a normal component of epidermal basement membrane, which shows altered expression in recessive dystrophic epidermolysis bullosa.
The Journal of investigative dermatology 1988;90(5):639-42.
1987: Leigh I M; Purkis P E; Navsaria H A; Phillips T J
Treatment of chronic venous ulcers with sheets of cultured allogenic keratinocytes.
The British journal of dermatology 1987;117(5):591-7.
1986: Heagerty A H; Kennedy A R; Leigh I M; Purkis P; Eady R A
Identification of an epidermal basement membrane defect in recessive forms of dystrophic epidermolysis bullosa by LH 7:2 monoclonal antibody: use in diagnosis.
The British journal of dermatology 1986;115(2):125-31.

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