Michael Leitges

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Geraldes Pedro; Hiraoka-Yamamoto Junko; Matsumoto Motonobu; Clermont Allen; Leitges Michael; Marette Andre; Aiello Lloyd P; Kern Timothy S; King George L
Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy.
Madigan James P; Bodemann Brian O; Brady Donita C; Dewar Brian J; Keller Patricia J; Leitges Michael; Philips Mark R; Ridley Anne J; Der Channing J; Cox Adrienne D
Regulation of Rnd3 localization and function by protein kinase C alpha-mediated phosphorylation.
Regala Roderick P; Davis Rebecca K; Kunz Alyssa; Khoor Andras; Leitges Michael; Fields Alan P
Atypical protein kinase C{iota} is required for bronchioalveolar stem cell expansion and lung tumorigenesis.

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All Publications

2009: Geraldes Pedro; Hiraoka-Yamamoto Junko; Matsumoto Motonobu; Clermont Allen; Leitges Michael; Marette Andre; Aiello Lloyd P; Kern Timothy S; King George L
Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy.
Nature medicine 2009;15(11):1298-306.
2009: Madigan James P; Bodemann Brian O; Brady Donita C; Dewar Brian J; Keller Patricia J; Leitges Michael; Philips Mark R; Ridley Anne J; Der Channing J; Cox Adrienne D
Regulation of Rnd3 localization and function by protein kinase C alpha-mediated phosphorylation.
The Biochemical journal 2009;424(1):153-61.
2009: Regala Roderick P; Davis Rebecca K; Kunz Alyssa; Khoor Andras; Leitges Michael; Fields Alan P
Atypical protein kinase C{iota} is required for bronchioalveolar stem cell expansion and lung tumorigenesis.
Cancer research 2009;69(19):7603-11.
2009: Fernandez-Marcos Pablo J; Abu-Baker Shadi; Joshi Jayashree; Galvez Anita; Castilla Elias A; Cañamero Marta; Collado Manuel; Saez Carmen; Moreno-Bueno Gema; Palacios Jose; Leitges Michael; Serrano Manuel; Moscat Jorge; Diaz-Meco Maria T
Simultaneous inactivation of Par-4 and PTEN in vivo leads to synergistic NF-kappaB activation and invasive prostate carcinoma.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(31):12962-7.
2009: Jensen Thomas E; Maarbjerg Stine J; Rose Adam J; Leitges Michael; Richter Erik A
Knockout of the predominant conventional PKC isoform, PKCalpha, in mouse skeletal muscle does not affect contraction-stimulated glucose uptake.
American journal of physiology. Endocrinology and metabolism 2009;297(2):E340-8.
2009: Cantley James; Burchfield James G; Pearson Gemma L; Schmitz-Peiffer Carsten; Leitges Michael; Biden Trevor J
Deletion of PKCepsilon selectively enhances the amplifying pathways of glucose-stimulated insulin secretion via increased lipolysis in mouse beta-cells.
Diabetes 2009;58(8):1826-34.
2009: Liu Qinghang; Chen Xiongwen; Macdonnell Scott M; Kranias Evangelia G; Lorenz John N; Leitges Michael; Houser Steven R; Molkentin Jeffery D
Protein kinase C{alpha}, but not PKC{beta} or PKC{gamma}, regulates contractility and heart failure susceptibility: implications for ruboxistaurin as a novel therapeutic approach.
Circulation research 2009;105(2):194-200.
2009: Fehrenbach Kerstin; Lessmann Eva; Zorn Carolin N; Kuhny Marcel; Grochowy Gordon; Krystal Gerald; Leitges Michael; Huber Michael
Steel factor enhances supraoptimal antigen-induced IL-6 production from mast cells via activation of protein kinase C-beta.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(12):7897-905.
2009: Gruber Thomas; Hermann-Kleiter Natascha; Pfeifhofer-Obermair Christa; Lutz-Nicoladoni Christina; Thuille Nikolaus; Letschka Thomas; Barsig Johannes; Baudler Monika; Li Jianping; Metzler Barbara; Nüsslein-Hildesheim Barbara; Wagner Juergen; Leitges Michael; Baier Gottfried
PKC theta cooperates with PKC alpha in alloimmune responses of T cells in vivo.
Molecular immunology 2009;46(10):2071-9.
2009: Sajan Mini P; Standaert Mary L; Nimal Sonali; Varanasi Usha; Pastoor Tina; Mastorides Stephen; Braun Ursula; Leitges Michael; Farese Robert V
The critical role of atypical protein kinase C in activating hepatic SREBP-1c and NFkappaB in obesity.
Journal of lipid research 2009;50(6):1133-45.
2009: Huber Tobias B; Hartleben Björn; Winkelmann Kirstin; Schneider Lisa; Becker Jan U; Leitges Michael; Walz Gerd; Haller Hermann; Schiffer Mario
Loss of podocyte aPKClambda/iota causes polarity defects and nephrotic syndrome.
Journal of the American Society of Nephrology : JASN 2009;20(4):798-806.
2009: Harja Evis; Chang Jong Sun; Lu Yan; Leitges Michael; Zou Yu Shan; Schmidt Ann Marie; Yan Shi-Fang
Mice deficient in PKCbeta and apolipoprotein E display decreased atherosclerosis.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(4):1081-91.
2009: Chen Rong; Furman Cheryse A; Zhang Minjia; Kim Myung N; Gereau Robert W; Leitges Michael; Gnegy Margaret E
Protein kinase Cbeta is a critical regulator of dopamine transporter trafficking and regulates the behavioral response to amphetamine in mice.
The Journal of pharmacology and experimental therapeutics 2009;328(3):912-20.
2009: Fields Alan P; Calcagno Shelly R; Krishna Murli; Rak Sofija; Leitges Michael; Murray Nicole R
Protein kinase Cbeta is an effective target for chemoprevention of colon cancer.
Cancer research 2009;69(4):1643-50.
2009: Murray Nicole R; Weems Justin; Braun Ursula; Leitges Michael; Fields Alan P
Protein kinase C betaII and PKCiota/lambda: collaborating partners in colon cancer promotion and progression.
Cancer research 2009;69(2):656-62.
2009: Yang Jun-Qi; Leitges Michael; Duran Angeles; Diaz-Meco Maria T; Moscat Jorge
Loss of PKC lambda/iota impairs Th2 establishment and allergic airway inflammation in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(4):1099-104.
2009: Poussin Mathilde A; Leitges Michael; Goldfine Howard
The ability of Listeria monocytogenes PI-PLC to facilitate escape from the macrophage phagosome is dependent on host PKCbeta.
Microbial pathogenesis 2009;46(1):1-5.
2009: Zorn Carolin N; Keck Simone; Hendriks Rudi W; Leitges Michael; Freudenberg Marina A; Huber Michael
Bruton's tyrosine kinase is dispensable for the Toll-like receptor-mediated activation of mast cells.
Cellular signalling 2009;21(1):79-86.
2009: Tossidou Irini; Starker Gabriele; Kruger Janna; Meier Matthias; Leitges Michael; Haller Hermann; Schiffer Mario
PKC-alpha modulates TGF-beta signaling and impairs podocyte survival.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009;24(5-6):627-34.
2009: Koyanagi Masamichi; Iwasaki Masayoshi; Haendeler Judith; Leitges Michael; Zeiher Andreas M; Dimmeler Stefanie
Wnt5a increases cardiac gene expressions of cultured human circulating progenitor cells via a PKC delta activation.
PloS one 2009;4(6):e5765.
2008: Letschka Thomas; Kollmann Veronika; Pfeifhofer-Obermair Christa; Lutz-Nicoladoni Christina; Obermair Gerald J; Fresser Friedrich; Leitges Michael; Hermann-Kleiter Natascha; Kaminski Sandra; Baier Gottfried
PKC-theta selectively controls the adhesion-stimulating molecule Rap1.
Blood 2008;112(12):4617-27.
2008: Alfa Cissé Moustapha; Louis Krystel; Braun Uschi; Mari Bernard; Leitges Michael; Slack Barbara E; Fisher Abraham; Auberger Patrick; Checler Frédéric; Vincent Bruno
Isoform-specific contribution of protein kinase C to prion processing.
Molecular and cellular neurosciences 2008;39(3):400-10.
2008: Bossi Orit; Gartsbein Marina; Leitges Michael; Kuroki Toshio; Grossman Shlomo; Tennenbaum Tamar
UV irradiation increases ROS production via PKCdelta signaling in primary murine fibroblasts.
Journal of cellular biochemistry 2008;105(1):194-207.
2008: Joshi Jayashree; Fernandez-Marcos Pablo J; Galvez Anita; Amanchy Ramars; Linares Juan F; Duran Angeles; Pathrose Peterson; Leitges Michael; Cañamero Marta; Collado Manuel; Salas Clara; Serrano Manuel; Moscat Jorge; Diaz-Meco Maria T
Par-4 inhibits Akt and suppresses Ras-induced lung tumorigenesis.
The EMBO journal 2008;27(16):2181-93.
2008: Cameron Angus J; Procyk Katarzyna J; Leitges Michael; Parker Peter J
PKC alpha protein but not kinase activity is critical for glioma cell proliferation and survival.
International journal of cancer. Journal international du cancer 2008;123(4):769-79.
2008: Potok Mary Anne; Cha Kelly B; Hunt Andrea; Brinkmeier Michelle L; Leitges Michael; Kispert Andreas; Camper Sally A
WNT signaling affects gene expression in the ventral diencephalon and pituitary gland growth.
Developmental dynamics : an official publication of the American Association of Anatomists 2008;237(4):1006-20.
2008: Kong Linghua; Andrassy Martin; Chang Jong Sun; Huang Chun; Asai Tomohiro; Szabolcs Matthias J; Homma Shunichi; Liu Rui; Zou Yu Shan; Leitges Michael; Yan Shi Du; Ramasamy Ravichandran; Schmidt Ann Marie; Yan Shi-Fang
PKCbeta modulates ischemia-reperfusion injury in the heart.
American journal of physiology. Heart and circulatory physiology 2008;294(4):H1862-70.
2008: Fährmann Michael; Honisch Sarah; Kaufhold Marc-André; Leitges Michael; Beil Winfried
Stringent time-dependent transregulation of calcium calmodulin kinase II (CaMKII) is implicated in anti-apoptotic control.
Biochimica et biophysica acta 2008;1783(2):214-23.
2008: Gruber Thomas; Fresser Friedrich; Jenny Marcel; Uberall Florian; Leitges Michael; Baier Gottfried
PKCtheta cooperates with atypical PKCzeta and PKCiota in NF-kappaB transactivation of T lymphocytes.
Molecular immunology 2008;45(1):117-26.
2007: Zhao Tianyu; Zhou Xunlei; Szabó Nora; Leitges Michael; Alvarez-Bolado Gonzalo
Foxb1-driven Cre expression in somites and the neuroepithelium of diencephalon, brainstem, and spinal cord.
Genesis (New York, N.Y. : 2000) 2007;45(12):781-7.
2007: Schwegmann Anita; Guler Reto; Cutler Antony J; Arendse Berenice; Horsnell William G C; Flemming Alexandra; Kottmann Andreas H; Ryan Gregory; Hide Winston; Leitges Michael; Seoighe Cathal; Brombacher Frank
Protein kinase C delta is essential for optimal macrophage-mediated phagosomal containment of Listeria monocytogenes.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(41):16251-6.
2007: Schmitz-Peiffer Carsten; Laybutt D Ross; Burchfield James G; Gurisik Ebru; Narasimhan Sakura; Mitchell Christopher J; Pedersen David J; Braun Uschi; Cooney Gregory J; Leitges Michael; Biden Trevor J
Inhibition of PKCepsilon improves glucose-stimulated insulin secretion and reduces insulin clearance.
Cell metabolism 2007;6(4):320-8.
2007: Moulakakis Christina; Adam Stefanie; Seitzer Ulrike; Schromm Andra B; Leitges Michael; Stamme Cordula
Surfactant protein A activation of atypical protein kinase C zeta in IkappaB-alpha-dependent anti-inflammatory immune regulation.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(7):4480-91.
2007: Peirson Stuart N; Oster Henrik; Jones Sarah L; Leitges Michael; Hankins Mark W; Foster Russell G
Microarray analysis and functional genomics identify novel components of melanopsin signaling.
Current biology : CB 2007;17(16):1363-72.
2007: Farese Robert V; Sajan Mini P; Yang Hong; Li Pengfei; Mastorides Steven; Gower William R; Nimal Sonali; Choi Cheol Soo; Kim Sheene; Shulman Gerald I; Kahn C Ronald; Braun Ursula; Leitges Michael
Muscle-specific knockout of PKC-lambda impairs glucose transport and induces metabolic and diabetic syndromes.
The Journal of clinical investigation 2007;117(8):2289-301.
2007: Jakubcakova Vladimira; Oster Henrik; Tamanini Filippo; Cadenas Cristina; Leitges Michael; van der Horst Gijsbertus T J; Eichele Gregor
Light entrainment of the mammalian circadian clock by a PRKCA-dependent posttranslational mechanism.
Neuron 2007;54(5):831-43.
2007: Ma Jennifer S Y; Monu Ngozi; Shen David T; Mecklenbräuker Ingrid; Radoja Nadezda; Haydar Tarik F; Leitges Michael; Frey Alan B; Vukmanovic Stanislav; Radoja Sasa
Protein kinase Cdelta regulates antigen receptor-induced lytic granule polarization in mouse CD8+ CTL.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(12):7814-21.
2007: Epp Nikolas; Fürstenberger Gerhard; Müller Karsten; de Juanes Silvia; Leitges Michael; Hausser Ingrid; Thieme Florian; Liebisch Gerhard; Schmitz Gerd; Krieg Peter
12R-lipoxygenase deficiency disrupts epidermal barrier function.
The Journal of cell biology 2007;177(1):173-82.
2007: Meier Matthias; Menne Jan; Park Joon-Keun; Holtz Marcel; Gueler Faikah; Kirsch Thorsten; Schiffer Mario; Mengel Michael; Lindschau Carsten; Leitges Michael; Haller Hermann
Deletion of protein kinase C-epsilon signaling pathway induces glomerulosclerosis and tubulointerstitial fibrosis in vivo.
Journal of the American Society of Nephrology : JASN 2007;18(4):1190-8.
2007: Helfrich Iris; Schmitz Annika; Zigrino Paola; Michels Christian; Haase Ingo; le Bivic André; Leitges Michael; Niessen Carien M
Role of aPKC isoforms and their binding partners Par3 and Par6 in epidermal barrier formation.
The Journal of investigative dermatology 2007;127(4):782-91.
2007: Pracht Catrin; Minguet Susana; Leitges Michael; Reth Michael; Huber Michael
Association of protein kinase C-delta with the B cell antigen receptor complex.
Cellular signalling 2007;19(4):715-22.
2007: Meier Matthias; Park Joon-Keun; Overheu Daniel; Kirsch Torsten; Lindschau Carsten; Gueler Faikah; Leitges Michael; Menne Jan; Haller Hermann
Deletion of protein kinase C-beta isoform in vivo reduces renal hypertrophy but not albuminuria in the streptozotocin-induced diabetic mouse model.
Diabetes 2007;56(2):346-54.
2007: Lessmann Eva; Ngo Mike; Leitges Michael; Minguet Susana; Ridgway Neale D; Huber Michael
Oxysterol-binding protein-related protein (ORP) 9 is a PDK-2 substrate and regulates Akt phosphorylation.
Cellular signalling 2007;19(2):384-92.
2007: Abraham Diya; Oster Henrik; Huber Michael; Leitges Michael
The expression pattern of three mast cell specific proteases during mouse development.
Molecular immunology 2007;44(5):732-40.
2007: Kovac Judit; Oster Henrik; Leitges Michael
Expression of the atypical protein kinase C (aPKC) isoforms iota/lambda and zeta during mouse embryogenesis.
Gene expression patterns : GEP 2007;7(1-2):187-96.
2006: Masek Katherine S; Fiore Jim; Leitges Michael; Yan Shi-Fang; Freedman Bruce D; Hunter Christopher A
Host cell Ca2+ and protein kinase C regulate innate recognition of Toxoplasma gondii.
Journal of cell science 2006;119(Pt 21):4565-73.
2006: Lessmann Eva; Grochowy Gordon; Weingarten Lars; Giesemann Torsten; Aktories Klaus; Leitges Michael; Krystal Gerald; Huber Michael
Insulin and insulin-like growth factor-1 promote mast cell survival via activation of the phosphatidylinositol-3-kinase pathway.
Experimental hematology 2006;34(11):1532-41.
2006: Clayburgh Daniel R; Musch Mark W; Leitges Michael; Fu Yang-Xin; Turner Jerrold R
Coordinated epithelial NHE3 inhibition and barrier dysfunction are required for TNF-mediated diarrhea in vivo.
The Journal of clinical investigation 2006;116(10):2682-94.
2006: Menne J; Meier M; Park J-K; Boehne M; Kirsch T; Lindschau C; Ociepka R; Leitges M; Rinta-Valkama J; Holthofer H; Haller H
Nephrin loss in experimental diabetic nephropathy is prevented by deletion of protein kinase C alpha signaling in-vivo.
Kidney international 2006;70(8):1456-62.
2006: LaVallie Edward R; Chockalingam Priya S; Collins-Racie Lisa A; Freeman Bethany A; Keohan Cristin C; Leitges Michael; Dorner Andrew J; Morris Elisabeth A; Majumdar Manas K; Arai Maya
Protein kinase Czeta is up-regulated in osteoarthritic cartilage and is required for activation of NF-kappaB by tumor necrosis factor and interleukin-1 in articular chondrocytes.
The Journal of biological chemistry 2006;281(34):24124-37.
2006: Oster Henrik; Leitges Michael
Protein kinase C alpha but not PKCzeta suppresses intestinal tumor formation in ApcMin/+ mice.
Cancer research 2006;66(14):6955-63.
2006: von Essen Marina; Nielsen Martin W; Bonefeld Charlotte M; Boding Lasse; Larsen Jeppe M; Leitges Michael; Baier Gottfried; Odum Niels; Geisler Carsten
Protein kinase C (PKC) alpha and PKC theta are the major PKC isotypes involved in TCR down-regulation.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(12):7502-10.
2006: Hermann-Kleiter Natascha; Thuille Nikolaus; Pfeifhofer Christa; Gruber Thomas; Schäfer Michaela; Zitt Christof; Hatzelmann Armin; Schudt Christian; Leitges Michael; Baier Gottfried
PKCtheta and PKA are antagonistic partners in the NF-AT transactivation pathway of primary mouse CD3+ T lymphocytes.
Blood 2006;107(12):4841-8.
2006: Pfeifhofer Christa; Gruber Thomas; Letschka Thomas; Thuille Nikolaus; Lutz-Nicoladoni Christina; Hermann-Kleiter Natascha; Braun Uschi; Leitges Michael; Baier Gottfried
Defective IgG2a/2b class switching in PKC alpha-/- mice.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(10):6004-11.
2006: Lessmann Eva; Leitges Michael; Huber Michael
A redundant role for PKC-epsilon in mast cell signaling and effector function.
International immunology 2006;18(5):767-73.
2006: Oster Henrik; Abraham Diya; Leitges Michael
Expression of the protein kinase D (PKD) family during mouse embryogenesis.
Gene expression patterns : GEP 2006;6(4):400-8.
2006: Liu Jing; Yang Dan; Minemoto Yuzuru; Leitges Michael; Rosner Marsha R; Lin Anning
NF-kappaB is required for UV-induced JNK activation via induction of PKCdelta.
Molecular cell 2006;21(4):467-80.
2006: Yao Li-Jun; Leitges Michael; Vallon Volker
Mice lacking protein kinase C beta present modest increases in systolic blood pressure and NH4Cl-induced metabolic acidosis.
Kidney & blood pressure research 2006;29(1):36-42.
2005: Martin Pilar; Villares Ricardo; Rodriguez-Mascarenhas Sandra; Zaballos Angel; Leitges Michael; Kovac Judit; Sizing Irene; Rennert Paul; Márquez Gabriel; Martínez-A Carlos; Diaz-Meco María T; Moscat Jorge
Control of T helper 2 cell function and allergic airway inflammation by PKCzeta.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(28):9866-71.
2005: Stawowy Philipp; Margeta Christian; Blaschke Florian; Lindschau Carsten; Spencer-Hänsch Chantel; Leitges Michael; Biagini Giuseppe; Fleck Eckart; Graf Kristof
Protein kinase C epsilon mediates angiotensin II-induced activation of beta1-integrins in cardiac fibroblasts.
Cardiovascular research 2005;67(1):50-9.
2005: Kitaura Jiro; Eto Koji; Kinoshita Tatsuya; Kawakami Yuko; Leitges Michael; Lowell Clifford A; Kawakami Toshiaki
Regulation of highly cytokinergic IgE-induced mast cell adhesion by Src, Syk, Tec, and protein kinase C family kinases.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(8):4495-504.
2005: Klein Gunnar; Schaefer Arnd; Hilfiker-Kleiner Denise; Oppermann Dagmar; Shukla Praphulla; Quint Anja; Podewski Eva; Hilfiker Andres; Schröder Frank; Leitges Michael; Drexler Helmut
Increased collagen deposition and diastolic dysfunction but preserved myocardial hypertrophy after pressure overload in mice lacking PKCepsilon.
Circulation research 2005;96(7):748-55.
2005: Kitaura Jiro; Kinoshita Tatsuya; Matsumoto Masaaki; Chung Shaun; Kawakami Yuko; Leitges Michael; Wu Dianqing; Lowell Clifford A; Kawakami Toshiaki
IgE- and IgE+Ag-mediated mast cell migration in an autocrine/paracrine fashion.
Blood 2005;105(8):3222-9.
2005: Andrassy Martin; Belov Dmitry; Harja Evis; Zou Yu Shan; Leitges Michael; Katus Hugo A; Nawroth Peter P; Yan Shi Du; Schmidt Ann Marie; Yan Shi-Fang
Central role of PKCbeta in neointimal expansion triggered by acute arterial injury.
Circulation research 2005;96(4):476-83.
2005: Singh Manvendra K; Petry Marianne; Haenig Bénédicte; Lescher Birgit; Leitges Michael; Kispert Andreas
The T-box transcription factor Tbx15 is required for skeletal development.
Mechanisms of development 2005;122(2):131-44.
2005: Gruber Thomas; Thuille Nikolaus; Hermann-Kleiter Natascha; Leitges Michael; Baier Gottfried
Protein kinase Cepsilon is dispensable for TCR/CD3-signaling.
Molecular immunology 2005;42(3):305-10.
2005: Gruber Thomas; Barsig Johannes; Pfeifhofer Christa; Ghaffari-Tabrizi Nassim; Tinhofer Inge; Leitges Michael; Baier Gottfried
PKCdelta is involved in signal attenuation in CD3+ T cells.
Immunology letters 2005;96(2):291-3.
2004: Leitges Michael; Kovac Judit; Plomann Markus; Linden David J
A unique PDZ ligand in PKCalpha confers induction of cerebellar long-term synaptic depression.
Neuron 2004;44(4):585-94.
2004: Durán Angeles; Rodriguez Angelina; Martin Pilar; Serrano Manuel; Flores Juana Maria; Leitges Michael; Diaz-Meco María T; Moscat Jorge
Crosstalk between PKCzeta and the IL4/Stat6 pathway during T-cell-mediated hepatitis.
The EMBO journal 2004;23(23):4595-605.
2004: Kawakami Yuko; Nishimoto Hajime; Kitaura Jiro; Maeda-Yamamoto Mari; Kato Roberta M; Littman Dan R; Leitges Michael; Rawlings David J; Kawakami Toshiaki
Protein kinase C betaII regulates Akt phosphorylation on Ser-473 in a cell type- and stimulus-specific fashion.
The Journal of biological chemistry 2004;279(46):47720-5.
2004: Liu Yan; Su Weidong; Thompson E Aubrey; Leitges Michael; Murray Nicole R; Fields Alan P
Protein kinase CbetaII regulates its own expression in rat intestinal epithelial cells and the colonic epithelium in vivo.
The Journal of biological chemistry 2004;279(44):45556-63.
2004: Mecklenbräuker Ingrid; Kalled Susan L; Leitges Michael; Mackay Fabienne; Tarakhovsky Alexander
Regulation of B-cell survival by BAFF-dependent PKCdelta-mediated nuclear signalling.
Nature 2004;431(7007):456-61.
2004: Oster Henrik; Eichele Gregor; Leitges Michael
Differential expression of atypical PKCs in the adult mouse brain.
Brain research. Molecular brain research 2004;127(1-2):79-88.
2004: Menne Jan; Park Joon-Keun; Boehne Martin; Elger Marlies; Lindschau Carsten; Kirsch Torsten; Meier Matthias; Gueler Faikah; Fiebeler Annette; Bahlmann Ferdinand H; Leitges Michael; Haller Hermann
Diminished loss of proteoglycans and lack of albuminuria in protein kinase C-alpha-deficient diabetic mice.
Diabetes 2004;53(8):2101-9.
2004: Mayr Manuel; Metzler Bernhard; Chung Yuen-Li; McGregor Emma; Mayr Ursula; Troy Helen; Hu Yanhua; Leitges Michael; Pachinger Otmar; Griffiths John R; Dunn Michael J; Xu Qingbo
Ischemic preconditioning exaggerates cardiac damage in PKC-delta null mice.
American journal of physiology. Heart and circulatory physiology 2004;287(2):H946-56.
2004: Mayr Manuel; Chung Yuen-Li; Mayr Ursula; McGregor Emma; Troy Helen; Baier Gottfried; Leitges Michael; Dunn Michael J; Griffiths John R; Xu Qingbo
Loss of PKC-delta alters cardiac metabolism.
American journal of physiology. Heart and circulatory physiology 2004;287(2):H937-45.
2004: Yao Lijun; Huang Dan-Yang; Pfaff Imke L; Nie Xin; Leitges Michael; Vallon Volker
Evidence for a role of protein kinase C-alpha in urine concentration.
American journal of physiology. Renal physiology 2004;287(2):F299-304.
2004: Redling Stephanie; Pfaff Imke L; Leitges Michael; Vallon Volker
Immunolocalization of protein kinase C isoenzymes alpha, beta I, beta II, delta, and epsilon in mouse kidney.
American journal of physiology. Renal physiology 2004;287(2):F289-98.
2004: Thuille Nikolaus; Gruber Thomas; Böck Günther; Leitges Michael; Baier Gottfried
Protein kinase C beta is dispensable for TCR-signaling.
Molecular immunology 2004;41(4):385-90.
2004: Rabeler Roland; Mittag Jens; Geffers Lars; Rüther Ulrich; Leitges Michael; Parlow Albert F; Visser Theo J; Bauer Karl
Generation of thyrotropin-releasing hormone receptor 1-deficient mice as an animal model of central hypothyroidism.
Molecular endocrinology (Baltimore, Md.) 2004;18(6):1450-60.
2004: Bussen Markus; Petry Marianne; Schuster-Gossler Karin; Leitges Michael; Gossler Achim; Kispert Andreas
The T-box transcription factor Tbx18 maintains the separation of anterior and posterior somite compartments.
Genes & development 2004;18(10):1209-21.
2004: Luan Hongmei; Leitges Michael; Gupta Rita R; Pacheco Daniel; Seidner Andres; Liggett Jessica; Ito Yasuki; Kowluru Renu; Berkowitz Bruce A
Effect of PKCbeta on retinal oxygenation response in experimental diabetes.
Investigative ophthalmology & visual science 2004;45(3):937-42.
2004: Durán Angeles; Serrano Manuel; Leitges Michael; Flores Juana M; Picard Sylvain; Brown Jacques P; Moscat Jorge; Diaz-Meco Maria T
The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis.
Developmental cell 2004;6(2):303-9.
2004: Bandyopadhyay Gautam; Standaert Mary L; Sajan Mini P; Kanoh Yoshinori; Miura Atsushi; Braun Uschi; Kruse Friederike; Leitges Michael; Farese Robert V
Protein kinase C-lambda knockout in embryonic stem cells and adipocytes impairs insulin-stimulated glucose transport.
Molecular endocrinology (Baltimore, Md.) 2004;18(2):373-83.
2003: Li Chaohong; Wernig Florian; Leitges Michael; Hu Yanhua; Xu Qingbo
Mechanical stress-activated PKCdelta regulates smooth muscle cell migration.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(14):2106-8.
2003: Ahmad Saifur R; Lidington Elaine A; Ohta Rieko; Okada Noriko; Robson Michael G; Davies Kevin A; Leitges Michael; Harris Claire L; Haskard Dorian O; Mason Justin C
Decay-accelerating factor induction by tumour necrosis factor-alpha, through a phosphatidylinositol-3 kinase and protein kinase C-dependent pathway, protects murine vascular endothelial cells against complement deposition.
Immunology 2003;110(2):258-68.
2003: Gundlfinger Anja; Kapfhammer Josef P; Kruse Friederike; Leitges Michael; Metzger Friedrich
Different regulation of Purkinje cell dendritic development in cerebellar slice cultures by protein kinase Calpha and -beta.
Journal of neurobiology 2003;57(1):95-109.
2003: Hernandez A Ivan; Blace Nancy; Crary John F; Serrano Peter A; Leitges Michael; Libien Jenny M; Weinstein Gila; Tcherapanov Andrew; Sacktor Todd Charlton
Protein kinase M zeta synthesis from a brain mRNA encoding an independent protein kinase C zeta catalytic domain. Implications for the molecular mechanism of memory.
The Journal of biological chemistry 2003;278(41):40305-16.
2003: Lindschau Carsten; Quass Petra; Menne Jan; Güler Faikah; Fiebeler Anette; Leitges Michael; Luft Friedrich C; Haller Hermann
Glucose-induced TGF-beta1 and TGF-beta receptor-1 expression in vascular smooth muscle cells is mediated by protein kinase C-alpha.
Hypertension 2003;42(3):335-41.
2003: Brandt Dominique T; Goerke Axel; Heuer Marion; Gimona Mario; Leitges Michael; Kremmer Elisabeth; Lammers Reiner; Haller Hermann; Mischak Harald
Protein kinase C delta induces Src kinase activity via activation of the protein tyrosine phosphatase PTP alpha.
The Journal of biological chemistry 2003;278(36):34073-8.
2003: Kawakami Yuko; Kitaura Jiro; Yao Libo; McHenry Robert W; Kawakami Yu; Newton Alexandra C; Kang Shin; Kato Roberta M; Leitges Michael; Rawlings David J; Kawakami Toshiaki
A Ras activation pathway dependent on Syk phosphorylation of protein kinase C.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(16):9470-5.
2003: Pfeifhofer Christa; Kofler Kurt; Gruber Thomas; Tabrizi Nassim Ghaffari; Lutz Christina; Maly Karl; Leitges Michael; Baier Gottfried
Protein kinase C theta affects Ca2+ mobilization and NFAT cell activation in primary mouse T cells.
The Journal of experimental medicine 2003;197(11):1525-35.
2003: Pilz Andreas; Ramsauer Katrin; Heidari Hamid; Leitges Michael; Kovarik Pavel; Decker Thomas
Phosphorylation of the Stat1 transactivating domain is required for the response to type I interferons.
EMBO reports 2003;4(4):368-73.
2002: Martin Pilar; Duran Angeles; Minguet Susana; Gaspar María-Luisa; Diaz-Meco Maria-Teresa; Rennert Paul; Leitges Michael; Moscat Jorge
Role of zeta PKC in B-cell signaling and function.
The EMBO journal 2002;21(15):4049-57.
2002: Su Thomas T; Guo Beichu; Kawakami Yuko; Sommer Karen; Chae Keun; Humphries Lisa A; Kato Roberta M; Kang Shin; Patrone Lisa; Wall Randolph; Teitell Michael; Leitges Michael; Kawakami Toshiaki; Rawlings David J
PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling.
Nature immunology 2002;3(8):780-6.
2002: Maly Karl; Strese Kukka; Kampfer Sonja; Ueberall Florian; Baier Gottfried; Ghaffari-Tabrizi Nassim; Grunicke Hans H; Leitges Michael
Critical role of protein kinase C alpha and calcium in growth factor induced activation of the Na(+)/H(+) exchanger NHE1.
FEBS letters 2002;521(1-3):205-10.
2002: Leitges Michael; Gimborn Kerstin; Elis Winfried; Kalesnikoff Janet; Hughes Michael R; Krystal Gerald; Huber Michael
Protein kinase C-delta is a negative regulator of antigen-induced mast cell degranulation.
Molecular and cellular biology 2002;22(12):3970-80.
2002: Wheeler Deric L; Reddig Peter J; Dreckschmidt Nancy E; Leitges Michael; Verma Ajit K
Protein kinase Cdelta-mediated signal to ornithine decarboxylase induction is independent of skin tumor suppression.
Oncogene 2002;21(22):3620-30.
2002: Kalesnikoff Janet; Baur Nicole; Leitges Michael; Hughes Michael R; Damen Jacqueline E; Huber Michael; Krystal Gerald
SHIP negatively regulates IgE + antigen-induced IL-6 production in mast cells by inhibiting NF-kappa B activity.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(9):4737-46.
2002: Mecklenbräuker Ingrid; Saijo Kaoru; Zheng Nai-Ying; Leitges Michael; Tarakhovsky Alexander
Protein kinase Cdelta controls self-antigen-induced B-cell tolerance.
Nature 2002;416(6883):860-5.
2002: Leitges Michael; Plomann Markus; Standaert Mary L; Bandyopadhyay Gautam; Sajan Mini P; Kanoh Yoshinori; Farese Robert V;
Knockout of PKC alpha enhances insulin signaling through PI3K.
Molecular endocrinology (Baltimore, Md.) 2002;16(4):847-58.
2002: Suzuma Kiyoshi; Takahara Noriko; Suzuma Izumi; Isshiki Keiji; Ueki Kohjiro; Leitges Michael; Aiello Lloyd Paul; King George L
Characterization of protein kinase C beta isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(2):721-6.
2001: Leitges M; Mayr M; Braun U; Mayr U; Li C; Pfister G; Ghaffari-Tabrizi N; Baier G; Hu Y; Xu Q
Exacerbated vein graft arteriosclerosis in protein kinase Cdelta-null mice.
The Journal of clinical investigation 2001;108(10):1505-12.
2001: Leitges M; Sanz L; Martin P; Duran A; Braun U; García J F; Camacho F; Diaz-Meco M T; Rennert P D; Moscat J
Targeted disruption of the zetaPKC gene results in the impairment of the NF-kappaB pathway.
Molecular cell 2001;8(4):771-80.
2001: Leitges M; Elis W; Gimborn K; Huber M
Rottlerin-independent attenuation of pervanadate-induced tyrosine phosphorylation events by protein kinase C-delta in hemopoietic cells.
Laboratory investigation; a journal of technical methods and pathology 2001;81(8):1087-95.
2000: Bauer B; Krumböck N; Ghaffari-Tabrizi N; Kampfer S; Villunger A; Wilda M; Hameister H; Utermann G; Leitges M; Uberall F; Baier G
T cell expressed PKCtheta demonstrates cell-type selective function.
European journal of immunology 2000;30(12):3645-54.
2000: Satterthwaite A B; Willis F; Kanchanastit P; Fruman D; Cantley L C; Helgason C D; Humphries R K; Lowell C A; Simon M; Leitges M; Tarakhovsky A; Tedder T F; Lesche R; Wu H; Witte O N
A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(12):6687-92.
2000: Leitges M; Neidhardt L; Haenig B; Herrmann B G; Kispert A
The paired homeobox gene Uncx4.1 specifies pedicles, transverse processes and proximal ribs of the vertebral column.
Development (Cambridge, England) 2000;127(11):2259-67.
2000: Yan S F; Lu J; Zou Y S; Kisiel W; Mackman N; Leitges M; Steinberg S; Pinsky D; Stern D
Protein kinase C-beta and oxygen deprivation. A novel Egr-1-dependent pathway for fibrin deposition in hypoxemic vasculature.
The Journal of biological chemistry 2000;275(16):11921-8.
1999: Standaert M L; Bandyopadhyay G; Galloway L; Soto J; Ono Y; Kikkawa U; Farese R V; Leitges M
Effects of knockout of the protein kinase C beta gene on glucose transport and glucose homeostasis.
Endocrinology 1999;140(10):4470-7.
1998: Plomann M; Lange R; Vopper G; Cremer H; Heinlein U A; Scheff S; Baldwin S A; Leitges M; Cramer M; Paulsson M; Barthels D
PACSIN, a brain protein that is upregulated upon differentiation into neuronal cells.
European journal of biochemistry / FEBS 1998;256(1):201-11.
1998: Chan V W; Mecklenbräuker I; Su I; Texido G; Leitges M; Carsetti R; Lowell C A; Rajewsky K; Miyake K; Tarakhovsky A
The molecular mechanism of B cell activation by toll-like receptor protein RP-105.
The Journal of experimental medicine 1998;188(1):93-101.

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