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Bruno Lemaitre

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Chemicals & Drugs

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Publications

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Bruno Lemaitre; Stephen E Girardin
Translation inhibition and metabolic stress pathways in the host response to bacterial pathogens.
Jeremy K Herren; Juan C Paredes; Fanny Schüpfer; Bruno Lemaitre
Vertical transmission of a Drosophila endosymbiont via cooption of the yolk transport and internalization machinery.
Dani Osman; Mickaël Poidevin; Wan-Chi Su; Yu-Chen Tsai; Nicolas Buchon; Sveta Chakrabarti; Yu-Ting Huang; Bruno Lemaitre
Autocrine and paracrine unpaired signaling regulate intestinal stem cell maintenance and division.

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All Publications

2013: Bruno Lemaitre; Stephen E Girardin
Translation inhibition and metabolic stress pathways in the host response to bacterial pathogens.
Nature reviews. Microbiology 2013;11(6):365-9.
2013: Jeremy K Herren; Juan C Paredes; Fanny Schüpfer; Bruno Lemaitre
Vertical transmission of a Drosophila endosymbiont via cooption of the yolk transport and internalization machinery.
mBio 2013;4(2):.
2012: Dani Osman; Mickaël Poidevin; Wan-Chi Su; Yu-Chen Tsai; Nicolas Buchon; Sveta Chakrabarti; Yu-Ting Huang; Bruno Lemaitre
Autocrine and paracrine unpaired signaling regulate intestinal stem cell maintenance and division.
Journal of cell science 2012;125(Pt 24):5944-9.
2012: Claudine Neyen; Mickaël Poidevin; Alain Roussel; Bruno Lemaitre
Tissue- and ligand-specific sensing of gram-negative infection in drosophila by PGRP-LC isoforms and PGRP-LE.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(4):1886-97.
2012: Sveta Chakrabarti; Nicolas Buchon; Peter Liehl; Bruno Lemaitre
Infection-induced host translational blockage inhibits immune responses and epithelial renewal in the Drosophila gut.
Cell host & microbe 2012;12(1):60-70.
2012: Nichole A Broderick; Bruno Lemaitre
Gut-associated microbes of Drosophila melanogaster.
Gut microbes 2012;3(4):307-21.
2012: Jeremy Herren; Bruno Lemaitre
Insect-microbe interactions: the good, the bad and the others.
Current opinion in microbiology 2012;15(3):217-9.
2012: Bruno Lemaitre; Lydia Michaut; Emmanuelle Nicolas; Jean-Marc Reichhart; Jules A Hoffmann
Pillars article: the dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell. 1996. 86: 973-983.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(11):5210-20.
2011: Juan C Paredes; Mickaël Poidevin; David P Welchman; Bruno Lemaitre
Negative regulation by amidase PGRPs shapes the Drosophila antibacterial response and protects the fly from innocuous infection.
Immunity 2011;35(5):770-9.
2011: Takayuki Kuraishi; Olivier Binggeli; Nicolas Buchon; Onya Opota; Bruno Lemaitre
Genetic evidence for a protective role of the peritrophic matrix against intestinal bacterial infection in Drosophila melanogaster.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(38):15966-71.
2011: Onya Opota; Alain Roussel; Isabelle Vallet-Gély; F Gisou van der Goot; Renaud Vincentelli; Manuel Rodrigo Gonzalez; Ioan Iacovache; Christine Kellenberger; Bruno Lemaitre
Monalysin, a novel ß-pore-forming toxin from the Drosophila pathogen Pseudomonas entomophila, contributes to host intestinal damage and lethality.
PLoS pathogens 2011;7(9):e1002259.
2010: Isabelle Vallet-Gely; Onya Opota; Audrey Boniface; Alexey Novikov; Bruno Lemaitre
A secondary metabolite acting as a signalling molecule controls Pseudomonas entomophila virulence.
Cellular microbiology 2010;12(11):1666-79.
2010: Isabelle Vallet-Gely; Alexey Novikov; Luis Augusto; Peter Liehl; Gérard Bolbach; Maria Péchy-Tarr; Pierre Cosson; Christoph Keel; Martine Caroff; Bruno Lemaitre
Association of hemolytic activity of Pseudomonas entomophila, a versatile soil bacterium, with cyclic lipopeptide production.
Applied and environmental microbiology 2010;76(3):910-21.
2008: Christoph Scherfer; Huaping Tang; Zakaria Kambris; Nouara Lhocine; Carl Hashimoto; Bruno Lemaitre
Drosophila Serpin-28D regulates hemolymph phenoloxidase activity and adult pigmentation.
Developmental biology 2008;323(2):189-96.
2008: Huaping Tang; Zakaria Kambris; Bruno Lemaitre; Carl Hashimoto
A serpin that regulates immune melanization in the respiratory system of Drosophila.
Developmental cell 2008;15(4):617-26.
2008: Nouara Lhocine; Paulo S Ribeiro; Nicolas Buchon; Alexander Wepf; Rebecca Wilson; Tencho Tenev; Bruno Lemaitre; Matthias Gstaiger; Pascal Meier; François Leulier
PIMS modulates immune tolerance by negatively regulating Drosophila innate immune signaling.
Cell host & microbe 2008;4(2):147-58.
2008: François Leulier; Bruno Lemaitre
Toll-like receptors--taking an evolutionary approach.
Nature reviews. Genetics 2008;9(3):165-78.
2007: Bruno Lemaitre; Jules Hoffmann
The host defense of Drosophila melanogaster.
Annual review of immunology 2007;25():697-743.
2007: Carlos Acosta Muniz; Danielle Jaillard; Bruno Lemaitre; Frédéric Boccard
Erwinia carotovora Evf antagonizes the elimination of bacteria in the gut of Drosophila larvae.
Cellular microbiology 2007;9(1):106-19.
2006: François Leulier; Nouara Lhocine; Bruno Lemaitre; Pascal Meier
The Drosophila inhibitor of apoptosis protein DIAP2 functions in innate immunity and is essential to resist gram-negative bacterial infection.
Molecular and cellular biology 2006;26(21):7821-31.
2006: Huaping Tang; Zakaria Kambris; Bruno Lemaitre; Carl Hashimoto
Two proteases defining a melanization cascade in the immune system of Drosophila.
The Journal of biological chemistry 2006;281(38):28097-104.
2006: Christoph Scherfer; Mousumi R Qazi; Kuniaki Takahashi; Ryu Ueda; Mitchell S Dushay; Ulrich Theopold; Bruno Lemaitre
The Toll immune-regulated Drosophila protein Fondue is involved in hemolymph clotting and puparium formation.
Developmental biology 2006;295(1):156-63.
2006: Peter Liehl; Mark Blight; nicolas vodovar; Frédéric Boccard; Bruno Lemaitre
Prevalence of local immune response against oral infection in a Drosophila/Pseudomonas infection model.
PLoS pathogens 2006;2(6):e56.
2006: nicolas vodovar; David Vallenet; Stéphane Cruveiller; Zoé Rouy; Valérie Barbe; Carlos Acosta; Laurence Cattolico; Claire Jubin; Aurélie Lajus; Béatrice Segurens; Benoît Vacherie; Patrick Wincker; Jean Weissenbach; Bruno Lemaitre; Claudine Médigue; Frédéric Boccard
Complete genome sequence of the entomopathogenic and metabolically versatile soil bacterium Pseudomonas entomophila.
Nature biotechnology 2006;24(6):673-9.
2006: Zakaria Kambris; Sylvain Brun; In-Hwan Jang; Hyuck-Jin Nam; Yves Romeo; Kuniaki Takahashi; Won-Jae Lee; Ryu Ueda; Bruno Lemaitre
Drosophila immunity: a large-scale in vivo RNAi screen identifies five serine proteases required for Toll activation.
Current biology : CB 2006;16(8):808-13.
2006: Anna Zaidman-Rémy; Mireille Hervé; Mickael Poidevin; Sebastien Pili-Floury; Min-Sung Kim; Didier Blanot; Byung-Ha Oh; Ryu Ueda; Dominique Mengin-Lecreulx; Bruno Lemaitre
The Drosophila amidase PGRP-LB modulates the immune response to bacterial infection.
Immunity 2006;24(4):463-73.
2006: Sylvain Brun; Sheila Vidal; Paul Spellman; Kuniaki Takahashi; Hervé Tricoire; Bruno Lemaitre
The MAPKKK Mekk1 regulates the expression of Turandot stress genes in response to septic injury in Drosophila.
Genes to cells : devoted to molecular & cellular mechanisms 2006;11(4):397-407.
2006: In-Hwan Jang; Naoyuki CHOSA; Sung-Hee Kim; Hyuck-Jin Nam; Bruno Lemaitre; Masanori Ochiai; Zakaria Kambris; Sylvain Brun; Carl Hashimoto; Masaaki Ashida; Paul T Brey; Won-Jae Lee
A Spätzle-processing enzyme required for toll signaling activation in Drosophila innate immunity.
Developmental cell 2006;10(1):45-55.
2005: Anni Kleino; Susanna Valanne; Johanna Ulvila; Jenni Kallio; Henna Myllymäki; Heidi Enwald; Svenja Stöven; Mickael Poidevin; Ryu Ueda; Dan Hultmark; Bruno Lemaitre; Mika Rämet
Inhibitor of apoptosis 2 and TAK1-binding protein are components of the Drosophila Imd pathway.
The EMBO journal 2005;24(19):3423-34.
2005: nicolas vodovar; Marisa Vinals; Peter Liehl; Alan Basset; Jeril Degrouard; Paul Spellman; Frédéric Boccard; Bruno Lemaitre
Drosophila host defense after oral infection by an entomopathogenic Pseudomonas species.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(32):11414-9.
2005: Dominique Mengin-Lecreulx; Bruno Lemaitre
Structure and metabolism of peptidoglycan and molecular requirements allowing its detection by the Drosophila innate immune system.
Journal of endotoxin research 2005;11(2):105-11.
2004: Carolyn R Stenbak; Ji-Hwan Ryu; François Leulier; Sebastien Pili-Floury; Claudine Parquet; Mireille Hervé; Catherine Chaput; Ivo G Boneca; Won-Jae Lee; Bruno Lemaitre; Dominique Mengin-Lecreulx
Peptidoglycan molecular requirements allowing detection by the Drosophila immune deficiency pathway.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(12):7339-48.
2004: Chung-I Chang; Sebastien Pili-Floury; Mireille Hervé; Claudine Parquet; Yogarany Chelliah; Bruno Lemaitre; Dominique Mengin-Lecreulx; Johann Deisenhofer
A Drosophila pattern recognition receptor contains a peptidoglycan docking groove and unusual L,D-carboxypeptidase activity.
PLoS biology 2004;2(9):E277.
2004: Bruno Lemaitre
The road to Toll.
Nature reviews. Immunology 2004;4(7):521-7.
2004: nicolas vodovar; Carlos Acosta; Bruno Lemaitre; Frédéric Boccard
Drosophila: a polyvalent model to decipher host-pathogen interactions.
Trends in microbiology 2004;12(5):235-42.
2004: Sebastien Pili-Floury; François Leulier; Kuniaki Takahashi; Kaoru Saigo; Emmanuel Samain; Ryu Ueda; Bruno Lemaitre
In vivo RNA interference analysis reveals an unexpected role for GNBP1 in the defense against Gram-positive bacterial infection in Drosophila adults.
The Journal of biological chemistry 2004;279(13):12848-53.
2003: François Leulier; Christelle Marchal; Isabelle Miletich; Bernadette Limbourg-Bouchon; Richard Benarous; Bruno Lemaitre
Directed expression of the HIV-1 accessory protein Vpu in Drosophila fat-body cells inhibits Toll-dependent immune responses.
EMBO reports 2003;4(10):976-81.
2003: François Leulier; Claudine Parquet; Sebastien Pili-Floury; Ji-Hwan Ryu; Martine Caroff; Won-Jae Lee; Dominique Mengin-Lecreulx; Bruno Lemaitre
The Drosophila immune system detects bacteria through specific peptidoglycan recognition.
Nature immunology 2003;4(5):478-84.
2003: Alan Basset; Phoebe Tzou; Bruno Lemaitre; Frédéric Boccard
A single gene that promotes interaction of a phytopathogenic bacterium with its insect vector, Drosophila melanogaster.
EMBO reports 2003;4(2):205-9.
2002: Ranjiv S Khush; William D Cornwell; Jennifer N Uram; Bruno Lemaitre
A ubiquitin-proteasome pathway represses the Drosophila immune deficiency signaling cascade.
Current biology : CB 2002;12(20):1728-37.
2002: Ennio De Gregorio; Bruno Lemaitre
The mosquito genome: the post-genomic era opens.
Nature 2002;419(6906):496-7.
2002: Ennio De Gregorio; Sung-Jun Han; Won-Jae Lee; Min-Ji Baek; Tsukasa Osaki; Shun-Ichiro Kawabata; Bok Luel Lee; Sadaaki Iwanaga; Bruno Lemaitre; Paul T Brey
An immune-responsive Serpin regulates the melanization cascade in Drosophila.
Developmental cell 2002;3(4):581-92.
2002: François Leulier; Sheila Vidal; Kaoru Saigo; Ryu Ueda; Bruno Lemaitre
Inducible expression of double-stranded RNA reveals a role for dFADD in the regulation of the antibacterial response in Drosophila adults.
Current biology : CB 2002;12(12):996-1000.
2002: Ennio De Gregorio; Paul Spellman; Phoebe Tzou; Gerald M Rubin; Bruno Lemaitre
The Toll and Imd pathways are the major regulators of the immune response in Drosophila.
The EMBO journal 2002;21(11):2568-79.
2002: Ranjiv S Khush; François Leulier; Bruno Lemaitre
Immunology. Pathogen surveillance--the flies have it.
Science (New York, N.Y.) 2002;296(5566):273-5.
2002: Phoebe Tzou; Jean-Marc Reichhart; Bruno Lemaitre
Constitutive expression of a single antimicrobial peptide can restore wild-type resistance to infection in immunodeficient Drosophila mutants.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(4):2152-7.
2002: Phoebe Tzou; Ennio De Gregorio; Bruno Lemaitre
How Drosophila combats microbial infection: a model to study innate immunity and host-pathogen interactions.
Current opinion in microbiology 2002;5(1):102-10.
2001: Ennio De Gregorio; Paul Spellman; Gerald M Rubin; Bruno Lemaitre
Genome-wide analysis of the Drosophila immune response by using oligonucleotide microarrays.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(22):12590-5.
2001: Sheila Vidal; Ranjiv S Khush; François Leulier; Phoebe Tzou; M Nakamura; Bruno Lemaitre
Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of rel/NF-kappaB-dependent innate immune responses.
Genes & development 2001;15(15):1900-12.
2001: Ranjiv S Khush; François Leulier; Bruno Lemaitre
Drosophila immunity: two paths to NF-kappaB.
Trends in immunology 2001;22(5):260-4.
2000: Phoebe Tzou; S Ohresser; Dominique Ferrandon; Maria Capovilla; Jean-Marc Reichhart; Bruno Lemaitre; Jules A Hoffmann; Jean-Luc Imler
Tissue-specific inducible expression of antimicrobial peptide genes in Drosophila surface epithelia.
Immunity 2000;13(5):737-48.
2000: Y S Kim; J H Ryu; S J Han; K H Choi; Ki-Bum Nam; In-Hwan Jang; Bruno Lemaitre; Paul T Brey; W J Lee
Gram-negative bacteria-binding protein, a pattern recognition receptor for lipopolysaccharide and beta-1,3-glucan that mediates the signaling for the induction of innate immune genes in Drosophila melanogaster cells.
The Journal of biological chemistry 2000;275(42):32721-7.
2000: François Leulier; A Rodriguez; Ranjiv S Khush; John M Abrams; Bruno Lemaitre
The Drosophila caspase Dredd is required to resist gram-negative bacterial infection.
EMBO reports 2000;1(4):353-8.
2000: Ranjiv S Khush; Bruno Lemaitre
Genes that fight infection: what the Drosophila genome says about animal immunity.
Trends in genetics : TIG 2000;16(10):442-9.
2000: Alan Basset; Ranjiv S Khush; A Braun; L Gardan; Frédéric Boccard; Jules A Hoffmann; Bruno Lemaitre
The phytopathogenic bacteria Erwinia carotovora infects Drosophila and activates an immune response.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(7):3376-81.
1999: pascal manfruelli; Jean-Marc Reichhart; R Steward; Jules A Hoffmann; Bruno Lemaitre
A mosaic analysis in Drosophila fat body cells of the control of antimicrobial peptide genes by the Rel proteins Dorsal and DIF.
The EMBO journal 1999;18(12):3380-91.
1998: Dominique Ferrandon; AC Jung; M Criqui; Bruno Lemaitre; Sandrine Uttenweiler; Lydia Michaut; Jean-Marc Reichhart; Jules A Hoffmann
A drosomycin-GFP reporter transgene reveals a local immune response in Drosophila that is not dependent on the Toll pathway.
The EMBO journal 1998;17(5):1217-27.
1998: E A Levashina; S Ohresser; Bruno Lemaitre; Jean-Luc Imler
Two distinct pathways can control expression of the gene encoding the Drosophila antimicrobial peptide metchnikowin.
Journal of molecular biology 1998;278(3):515-27.
1998: E Nicolas; Jean-Marc Reichhart; Jules A Hoffmann; Bruno Lemaitre
In vivo regulation of the IkappaB homologue cactus during the immune response of Drosophila.
The Journal of biological chemistry 1998;273(17):10463-9.
1997: Bruno Lemaitre; Jean-Marc Reichhart; Jules A Hoffmann
Drosophila host defense: differential induction of antimicrobial peptide genes after infection by various classes of microorganisms.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(26):14614-9.
1997: M Meister; Bruno Lemaitre; Jules A Hoffmann
Antimicrobial peptide defense in Drosophila.
BioEssays : news and reviews in molecular, cellular and developmental biology 1997;19(11):1019-26.
1996: Bruno Lemaitre; E Nicolas; L Michaut; Jean-Marc Reichhart; Jules A Hoffmann
The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults.
Cell 1996;86(6):973-83.
1996: E Nicolas; A J Nappi; Bruno Lemaitre
Expression of antimicrobial peptide genes after infection by parasitoid wasps in Drosophila.
Developmental and comparative immunology 1996;20(3):175-81.
1995: Bruno Lemaitre; E Kromer-Metzger; L Michaut; E Nicolas; M Meister; Philippe Georgel; Jean-Marc Reichhart; Jules A Hoffmann
A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(21):9465-9.
1995: Bruno Lemaitre; M Meister; S Govind; Philippe Georgel; Ruth Steward; Jean-Marc Reichhart; Jules A Hoffmann
Functional analysis and regulation of nuclear import of dorsal during the immune response in Drosophila.
The EMBO journal 1995;14(3):536-45.
1993: Philippe Georgel; M Meister; C Kappler; Bruno Lemaitre; Jean-Marc Reichhart; Jules A Hoffmann
Insect immunity: the diptericin promoter contains multiple functional regulatory sequences homologous to mammalian acute-phase response elements.
Biochemical and biophysical research communications 1993;197(2):508-17.
1993: Jean-Marc Reichhart; Philippe Georgel; M Meister; Bruno Lemaitre; C Kappler; Jules A Hoffmann
Expression and nuclear translocation of the rel/NF-kappa B-related morphogen dorsal during the immune response of Drosophila.
Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie 1993;316(10):1218-24.