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Hilmar Lemke

Research Profile

Chemicals & Drugs

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Hodgkin's Disease

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Ahmad Trad; Kosuke Yamamoto; Christine Desel; Hinrich P Hansen; Nina Hedemann; Katja Klausz; Hilmar Lemke; Inken Lorenzen; André Mauermann; Matthias Peipp; Stefan Rose-John; Mohammad Shomali; Joachim Grötzinger
ADAM17-overexpressing breast cancer cells selectively targeted by antibody-toxin conjugates.
Hans Lange; Oliver Hecht; Harry W Schroeder; Radu I Tanasa; Ahmad Trad; Michael Zemlin; Hilmar Lemke
Immunoglobulin class switching appears to be regulated by B-cell antigen receptor-specific T-cell action.
R I Tanasa; A Trad; Hans Lange; J Grötzinger; Hilmar Lemke
Allergen IgE-isotype-specific suppression by maternally derived monoclonal anti-IgG-idiotype.

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All Publications

2013: Ahmad Trad; Kosuke Yamamoto; Christine Desel; Hinrich P Hansen; Nina Hedemann; Katja Klausz; Hilmar Lemke; Inken Lorenzen; André Mauermann; Matthias Peipp; Stefan Rose-John; Mohammad Shomali; Joachim Grötzinger
ADAM17-overexpressing breast cancer cells selectively targeted by antibody-toxin conjugates.
Cancer immunology, immunotherapy : CII 2013;62(3):411-21.
2012: Hans Lange; Oliver Hecht; Harry W Schroeder; Radu I Tanasa; Ahmad Trad; Michael Zemlin; Hilmar Lemke
Immunoglobulin class switching appears to be regulated by B-cell antigen receptor-specific T-cell action.
European journal of immunology 2012;42(4):1016-29.
2010: R I Tanasa; A Trad; Hans Lange; J Grötzinger; Hilmar Lemke
Allergen IgE-isotype-specific suppression by maternally derived monoclonal anti-IgG-idiotype.
Allergy 2010;65(1):16-23.
2009: Hilmar Lemke; Radu Iulian Tanasa; Ahmad Trad; Hans Lange
Benefits and burden of the maternally-mediated immunological imprinting.
Autoimmunity reviews 2009;8(5):394-9.
2008: Hans Lange; Michael Zemlin; Radu Iulian Tanasa; Ahmad Trad; Thomas Weiss; Hauke Menning; Hilmar Lemke
Thymus-independent type 2 antigen induces a long-term IgG-related network memory.
Molecular immunology 2008;45(10):2847-60.
2004: Hinrich P Hansen; Andreas Recke; Ulrich Reineke; Bastian Von Tresckow; Peter Borchmann; Elke Pogge Von Strandmann; Hans Lange; Hilmar Lemke; Andreas Engert
The ectodomain shedding of CD30 is specifically regulated by peptide motifs in its cysteine-rich domains 2 and 5.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(7):893-5.
2004: Hilmar Lemke; Antonio Coutinho; Hans Lange
Lamarckian inheritance by somatically acquired maternal IgG phenotypes.
Trends in immunology 2004;25(4):180-6.
2003: Hilmar Lemke; Hinrich Hansen; Hans Lange
Non-genetic inheritable potential of maternal antibodies.
Vaccine 2003;21(24):3428-31.
2002: Hans Lange; Berit Kiesch; Isabelle Linden; Marcus Otto; Hermann J Thierse; Lee Shaw; Karen Maehnss; Hinrich Hansen; Hilmar Lemke
Reversal of the adult IgE high responder phenotype in mice by maternally transferred allergen-specific monoclonal IgG antibodies during a sensitive period in early ontogeny.
European journal of immunology 2002;32(11):3133-41.
2002: Karen Maehnss; Jörg Kobarg; Wilhelm H Schmitt; Hinrich P Hansen; Hans Lange; Elena Csernok; Wolfgang L Gross; Hilmar Lemke
Vitronectin- and fibronectin-containing immune complexes in primary systemic vasculitis.
Journal of autoimmunity 2002;18(3):239-50.
2002: Hinrich P Hansen; Bärbel Matthey; Stefan Barth; Tatiana Kisseleva; Thilo Mokros; Stephen J Davies; R Paul Beckett; Regina Foelster-Holst; Hans H Lange; Andreas Engert; Hilmar Lemke
Inhibition of metalloproteinases enhances the internalization of anti-CD30 antibody Ki-3 and the cytotoxic activity of Ki-3 immunotoxin.
International journal of cancer. Journal international du cancer 2002;98(2):210-5.
2002: Regina Fölster-Holst; Tilo Henseler; Jörg Wehde; Hilmar Lemke; Michael Weichenthal; Enno Christophers; Hinrich P Hansen
Soluble CD30 plasma concentrations correlate with disease activity in patients with atopic dermatitis.
Acta dermato-venereologica 2002;82(4):245-8.
2002: Hilmar Lemke; Hans Lange
Generalization of single immunological experiences by idiotypically mediated clonal connections.
Advances in immunology 2002;80():203-41.
2000: Hinrich P Hansen; Sebastian Dietrich; T Kisseleva; Thilo Mokros; Rolf Mentlein; H H Lange; G Murphy; Hilmar Lemke
CD30 shedding from Karpas 299 lymphoma cells is mediated by TNF-alpha-converting enzyme.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(12):6703-9.
1999: Hilmar Lemke; Hans Lange
Is there a maternally induced immunological imprinting phase à la Konrad Lorenz?
Scandinavian journal of immunology 1999;50(4):348-54.
1999: S Yazynin; Hans Lange; Thilo Mokros; S Deyev; Hilmar Lemke
A new phagemid vector for positive selection of recombinants based on a conditionally lethal barnase gene.
FEBS letters 1999;452(3):351-4.
1999: Alexander Klimka; Stefan Barth; Bärbel Matthey; Rob C Roovers; Hilmar Lemke; Hinrich Hansen; Jan-Willem Arends; Volker Diehl; Hennie Hoogenboom; Andreas Engert
An anti-CD30 single-chain Fv selected by phage display and fused to Pseudomonas exotoxin A (Ki-4(scFv)-ETA') is a potent immunotoxin against a Hodgkin-derived cell line.
British journal of cancer 1999;80(8):1214-22.
1999: Hans Lange; Jörg Kobarg; S Yazynin; M Solterbeck; M Henningsen; Hinrich Hansen; Hilmar Lemke
Genetic analysis of the maternally induced affinity enhancement in the non-Ox1 idiotypic antibody repertoire of the primary immune response to 2-phenyloxazolone.
Scandinavian journal of immunology 1999;49(1):55-66.
1998: M Seeger; H J Thierse; Hans Lange; Lee Shaw; Hinrich Hansen; Hilmar Lemke
Antigen-independent suppression of the IgE immune response to bee venom phospholipase A2 by maternally derived monoclonal IgG antibodies.
European journal of immunology 1998;28(7):2124-30.
1997: Jörg Kobarg; S Schnittger; C Fonatsch; Hilmar Lemke; MA Bowen; F Buck; Hinrich P Hansen
Characterization, mapping and partial cDNA sequence of the 57-kD intracellular Ki-1 antigen.
Experimental and clinical immunogenetics 1997;14(4):273-80.
1996: Hans Lange; M Solterbeck; C Berek; Hilmar Lemke
Correlation between immune maturation and idiotypic network recognition.
European journal of immunology 1996;26(9):2234-42.
1996: Hans Lange; Hilmar Lemke
Induction of a non-oscillating, long-lasting humoral immune response to an internal network antigen.
International immunology 1996;8(5):683-8.
1995: H P Hansen; T Kisseleva; Jörg Kobarg; O Horn-Lohrens; Bent H Havsteen; Hilmar Lemke
A zinc metalloproteinase is responsible for the release of CD30 on human tumor cell lines.
International journal of cancer. Journal international du cancer 1995;63(5):750-6.
1995: Roland Schnell; C Linnartz; A A Katouzi; G Schön; Heribert Bohlen; O Horn-Lohrens; R M Parwaresch; Hans Lange; Volker Diehl; Hilmar Lemke
Development of new ricin A-chain immunotoxins with potent anti-tumor effects against human Hodgkin cells in vitro and disseminated Hodgkin tumors in SCID mice using high-affinity monoclonal antibodies directed against the CD30 antigen.
International journal of cancer. Journal international du cancer 1995;63(2):238-44.
1995: O Horn-Lohrens; Markus Tiemann; Hans Lange; Jörg Kobarg; Martin Hafner; Hinrich Hansen; W Sterry; R M Parwaresch; Hilmar Lemke
Shedding of the soluble form of CD30 from the Hodgkin-analogous cell line L540 is strongly inhibited by a new CD30-specific antibody (Ki-4).
International journal of cancer. Journal international du cancer 1995;60(4):539-44.
1994: Hilmar Lemke; Hans Lange; C Berek
Maternal immunization modulates the primary immune response to 2-phenyl-oxazolone in BALB/c mice.
European journal of immunology 1994;24(12):3025-30.
1992: D Rohde; Hinrich Hansen; Martin Hafner; Hans Lange; V Mielke; Martin-Leo Hansmann; Hilmar Lemke
Cellular localizations and processing of the two molecular forms of the Hodgkin-associated Ki-1 (CD30) antigen. The protein kinase Ki-1/57 occurs in the nucleus.
The American journal of pathology 1992;140(2):473-82.
1990: Hinrich Hansen; G Bredfeldt; Bent H Havsteen; Hilmar Lemke
Protein kinase activity of the intracellular but not of the membrane-associated form of the Ki-1 antigen (CD30).
Research in immunology 1990;141(1):13-31.
1989: Hilmar Lemke; G Huss; J Bonmann; Hinrich Hansen
Determination of cell-bound Fc receptors using a cell adherence test (CAT).
Journal of immunological methods 1989;121(2):175-83.
1989: Hinrich Hansen; Hilmar Lemke; G Bredfeldt; I Könnecke; Bent H Havsteen
The Hodgkin-associated Ki-1 antigen exists in an intracellular and a membrane-bound form.
Biological chemistry Hoppe-Seyler 1989;370(5):409-16.
1985: Hilmar Lemke; R Krausse; J Lorenzen; Bent H Havsteen
Mycoplasma infection of cell lines can simulate the expression of Fc receptors by binding of the carbohydrate moiety of antibodies.
European journal of immunology 1985;15(5):442-7.