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Horst Lemoine

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Andreas Fischer; Claas Schmidt; Stefan Lachenicht; Dagmar Grittner; Marcus Winkler; Thomas Wrobel; Achim Rood; Horst Lemoine; Walter Frank; Manfred Braun
Synthesis of benzofuran, benzothiophene, and benzothiazole-based thioamides and their evaluation as K(ATP) channel openers.
Stefan Lachenicht; Andreas Fischer; Claas Schmidt; Marcus Winkler; Achim Rood; Horst Lemoine; Manfred Braun
Synthesis of modified 4H-1,2,4-benzothiadiazine-1,1-dioxides and determination of their affinity and selectivity for different types of K(ATP) channels.
Damian Stephan; E Salamon; Horst Weber; Ulrich Russ; Horst Lemoine; Ulrich Quast
KATP channel openers of the benzopyran type reach their binding site via the cytosol.

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All Publications

2010: Andreas Fischer; Claas Schmidt; Stefan Lachenicht; Dagmar Grittner; Marcus Winkler; Thomas Wrobel; Achim Rood; Horst Lemoine; Walter Frank; Manfred Braun
Synthesis of benzofuran, benzothiophene, and benzothiazole-based thioamides and their evaluation as K(ATP) channel openers.
ChemMedChem 2010;5(10):1749-59.
2009: Stefan Lachenicht; Andreas Fischer; Claas Schmidt; Marcus Winkler; Achim Rood; Horst Lemoine; Manfred Braun
Synthesis of modified 4H-1,2,4-benzothiadiazine-1,1-dioxides and determination of their affinity and selectivity for different types of K(ATP) channels.
ChemMedChem 2009;4(11):1850-8.
2006: Damian Stephan; E Salamon; Horst Weber; Ulrich Russ; Horst Lemoine; Ulrich Quast
KATP channel openers of the benzopyran type reach their binding site via the cytosol.
British journal of pharmacology 2006;149(2):199-205.
2005: Emanuele Carosati; Horst Lemoine; Roberto Spogli; Dagmar Grittner; Raimund Mannhold; Oriana Tabarrini; Stefano Sabatini; Violetta Cecchetti
Binding studies and GRIND/ALMOND-based 3D QSAR analysis of benzothiazine type K(ATP)-channel openers.
Bioorganic & medicinal chemistry 2005;13(19):5581-91.
2002: Ulrike Uhrig; Hans-Dieter Höltje; Raimund Mannhold; Horst Weber; Horst Lemoine
Molecular modeling and QSAR studies on K(ATP) channel openers of the benzopyran type.
Journal of molecular graphics & modelling 2002;21(1):37-45.
2002: Ekkehart Salamon; Raimund Mannhold; Horst Weber; Horst Lemoine; Walter Frank
6-Sulfonylchromenes as highly potent K(ATP)-channel openers.
Journal of medicinal chemistry 2002;45(5):1086-97.
1999: Horst Lemoine; Horst Weber; A Derix; U Uhrig; Hans-Dieter Höltje; Raimund Mannhold
Relaxant activity in rat aorta and trachea, conversion to a muscarinic receptor antagonist and structure-activity relationships of new K(ATP) activating 6-varied benzopyrans.
European journal of pharmacology 1999;378(1):85-97.
1999: Raimund Mannhold; Gabriele Cruciani; Horst Weber; Horst Lemoine; A Derix; C Weichel; M Clementi
6-Substituted benzopyrans as potassium channel activators: synthesis, vasodilator properties, and multivariate analysis.
Journal of medicinal chemistry 1999;42(6):981-91.
1999: A Teschemacher; Horst Lemoine
Kinetic analysis of drug-receptor interactions of long-acting beta2 sympathomimetics in isolated receptor membranes: evidence against prolonged effects of salmeterol and formoterol on receptor-coupled adenylyl cyclase.
The Journal of pharmacology and experimental therapeutics 1999;288(3):1084-92.
1998: Y Bao; Horst Lemoine
[Inquiry into the mechanism of long-acting bronchodilators].
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 1998;20(3):191-6.
1998: A Teschemacher; D Reinhardt; Horst Lemoine
Do parasympatholytic effects of long-acting beta 2-sympathomimetics contribute to their relaxant effects in airway smooth muscle cells?
Pulmonary pharmacology & therapeutics 1998;11(4):253-61.
1997: M Weiss; E M Schneider; S Liebert; S Mettler; Horst Lemoine
Vasoactive drugs inhibit oxygen radical production of neutrophils.
Immunopharmacology and immunotoxicology 1997;19(2):239-63.
1996: M Weiss; E M Schneider; Jörg Tarnow; S Mettler; M Krone; A Teschemacher; Horst Lemoine
Is inhibition of oxygen radical production of neutrophils by sympathomimetics mediated via beta-2 adrenoceptors?
The Journal of pharmacology and experimental therapeutics 1996;278(3):1105-13.
1995: W Voigt; M N Romanelli; Horst Lemoine; Raimund Mannhold; Silvia Dei; Elisabetta Teodori; Fulvio Gualtieri
Structural dependence of the allosteric interaction of semi-rigid verapamil analogues with dihydropyridine-binding in kitten heart.
European journal of pharmacology 1995;291(3):255-64.
1995: S Zink; P Rösen; Horst Lemoine
Micro- and macrovascular endothelial cells in beta-adrenergic regulation of transendothelial permeability.
The American journal of physiology 1995;269(5 Pt 1):C1209-18.
1993: S Zink; P Rösen; B Sackmann; Horst Lemoine
Regulation of endothelial permeability by beta-adrenoceptor agonists: contribution of beta 1- and beta 2-adrenoceptors.
Biochimica et biophysica acta 1993;1178(3):286-98.
1993: Horst Lemoine; Heinrich Worth; Dietrich Reinhardt
[Pharmacologic characterization of formoterol in comparison with isoprenaline, fenoterol and salbutamol in tracheal muscle strips and lung membranes of the guinea pig].
Pneumologie (Stuttgart, Germany) 1993;47(4):303-10.
1993: Silvia Dei; Maria Novella Romanelli; Serena Scapecchi; Elisabetta Teodori; Fulvio Gualtieri; Alberto Chiarini; W Voigt; Horst Lemoine
Verapamil analogues with restricted molecular flexibility: synthesis and pharmacological evaluation of the four isomers of alpha-[1-[3-[N-[1- [2-(3,4-dimethoxyphenyl)ethyl]]-N-methylamino]cyclohexyl]]-alpha- isopropyl-3,4-dimethoxybenzene-acetonitrile.
Journal of medicinal chemistry 1993;36(4):439-45.
1992: Horst Lemoine; C Overlack
Highly potent beta-2 sympathomimetics convert to less potent partial agonists as relaxants of guinea pig tracheae maximally contracted by carbachol. Comparison of relaxation with receptor binding and adenylate cyclase stimulation.
The Journal of pharmacology and experimental therapeutics 1992;261(1):258-70.
1992: Horst Lemoine; C Overlack; A Köhl; Heinrich Worth; Dietrich Reinhardt
Formoterol, fenoterol, and salbutamol as partial agonists for relaxation of maximally contracted guinea pig tracheae: comparison of relaxation with receptor binding.
Lung 1992;170(3):163-80.
1991: Horst Lemoine; A J Kaumann
Regional differences of beta 1- and beta 2-adrenoceptor-mediated functions in feline heart. A beta 2-adrenoceptor-mediated positive inotropic effect possibly unrelated to cyclic AMP.
Naunyn-Schmiedeberg's archives of pharmacology 1991;344(1):56-69.
1989: Horst Lemoine; K J Teng; S J Slee; A J Kaumann
On minimum cyclic AMP formation rates associated with positive inotropic effects mediated through beta 1-adrenoceptors in kitten myocardium. Beta 1-specific and non-adrenergic stimulant effects of denopamine.
Naunyn-Schmiedeberg's archives of pharmacology 1989;339(1-2):113-28.
1989: A J Kaumann; Horst Lemoine; U Schwederski-Menke; B Ehle
Relations between beta-adrenoceptor occupancy and increases of contractile force and adenylate cyclase activity induced by catecholamines in human ventricular myocardium. Acute desensitization and comparison with feline ventricle.
Naunyn-Schmiedeberg's archives of pharmacology 1989;339(1-2):99-112.
1989: Horst Lemoine; A Bilski; A J Kaumann
Xamoterol activates beta 1- but not beta 2-adrenoceptors in mammalian myocardium: comparison of its affinity for beta 1- and beta 2-adrenoceptors coupled to the adenylate cyclase in feline and human ventricle with positive inotropic effects.
Journal of cardiovascular pharmacology 1989;13(1):105-17.
1988: Horst Lemoine; H Schönell; A J Kaumann
Contribution of beta 1- and beta 2-adrenoceptors of human atrium and ventricle to the effects of noradrenaline and adrenaline as assessed with (-)-atenolol.
British journal of pharmacology 1988;95(1):55-66.
1985: E Gille; Horst Lemoine; B Ehle; A J Kaumann
The affinity of (-)-propranolol for beta 1- and beta 2-adrenoceptors of human heart. Differential antagonism of the positive inotropic effects and adenylate cyclase stimulation by (-)-noradrenaline and (-)-adrenaline.
Naunyn-Schmiedeberg's archives of pharmacology 1985;331(1):60-70.
1985: B Ehle; Horst Lemoine; A J Kaumann
Improved evaluation of binding of ligands to membranes containing several receptor-subtypes.
Naunyn-Schmiedeberg's archives of pharmacology 1985;331(1):52-9.
1985: Horst Lemoine; B Ehle; A J Kaumann
Direct labelling of beta 2-adrenoceptors. Comparison of binding potency of 3H-ICI 118,551 and blocking potency of ICI 118,551.
Naunyn-Schmiedeberg's archives of pharmacology 1985;331(1):40-51.