Username

Password

Preview

Sign-in free and Explore the Exciting World of BiomedExperts:

Over 1.500.000 Profiles
More than 1.800 Organizations worldwide
State of the Art Network Visualizations

Manage your own Profile
Locate Experts in your Country/Region
Locate Experts in your 1. and 2. Level Network
Connect to Experts Worldwide

NetworkView

Michael Lenardo

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Living Beings

Mice

Anatomy

Physiology

Disorders

Concepts & Ideas

Molecular Sequence Data

Sign-in to see full Profile

Sign-in to see all Coauthors

Publications

TOP 3
Randall Katrina L; Lambe Teresa; Johnson Andy; Treanor Bebhinn; Kucharska Edyta; Domaschenz Heather; Whittle Belinda; Tze Lina E; Enders Anselm; Crockford Tanya L; Bouriez-Jones Tiphaine; Alston Duncan; Cyster Jason G; Lenardo Michael J; Mackay Fabienne; Deenick Elissa K; Tangye Stuart G; Chan Tyani D; Camidge Tahra; Brink Robert; Vinuesa Carola G; Batista Facundo D; Cornall Richard J; Goodnow Christopher C
Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production.
Snow Andrew L; Marsh Rebecca A; Krummey Scott M; Roehrs Philip; Young Lisa R; Zhang Kejian; van Hoff Jack; Dhar Deepali; Nichols Kim E; Filipovich Alexandra H; Su Helen C; Bleesing Jack J; Lenardo Michael J
Restimulation-induced apoptosis of T cells is impaired in patients with X-linked lymphoproliferative disease caused by SAP deficiency.
Johnson Andy L; Aravind L; Shulzhenko Natalia; Morgun Andre; Choi See-Young; Crockford Tanya L; Lambe Teresa; Domaschenz Heather; Kucharska Edyta M; Zheng Lixin; Vinuesa Carola G; Lenardo Michael J; Goodnow Christopher C; Cornall Richard J; Schwartz Ronald H
Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection.

Sign-in to see all Publications

Sign in free and see...

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the visualized research activity
of experts around the globe

Sign-in to see more

Geonetwork of Michael Lenardo (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

Sign-in to see more

All Publications

2009: Randall Katrina L; Lambe Teresa; Johnson Andy; Treanor Bebhinn; Kucharska Edyta; Domaschenz Heather; Whittle Belinda; Tze Lina E; Enders Anselm; Crockford Tanya L; Bouriez-Jones Tiphaine; Alston Duncan; Cyster Jason G; Lenardo Michael J; Mackay Fabienne; Deenick Elissa K; Tangye Stuart G; Chan Tyani D; Camidge Tahra; Brink Robert; Vinuesa Carola G; Batista Facundo D; Cornall Richard J; Goodnow Christopher C
Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production.
Nature immunology 2009;10(12):1283-91.
2009: Snow Andrew L; Marsh Rebecca A; Krummey Scott M; Roehrs Philip; Young Lisa R; Zhang Kejian; van Hoff Jack; Dhar Deepali; Nichols Kim E; Filipovich Alexandra H; Su Helen C; Bleesing Jack J; Lenardo Michael J
Restimulation-induced apoptosis of T cells is impaired in patients with X-linked lymphoproliferative disease caused by SAP deficiency.
The Journal of clinical investigation 2009;119(10):2976-89.
2009: Johnson Andy L; Aravind L; Shulzhenko Natalia; Morgun Andre; Choi See-Young; Crockford Tanya L; Lambe Teresa; Domaschenz Heather; Kucharska Edyta M; Zheng Lixin; Vinuesa Carola G; Lenardo Michael J; Goodnow Christopher C; Cornall Richard J; Schwartz Ronald H
Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection.
Nature immunology 2009;10(8):831-9.
2009: Cadera Emily J; Wan Fengyi; Amin Rupesh H; Nolla Hector; Lenardo Michael J; Schlissel Mark S
NF-kappaB activity marks cells engaged in receptor editing.
The Journal of experimental medicine 2009;206(8):1803-16.
2009: Freundt Eric C; Yu Li; Park Elizabeth; Lenardo Michael J; Xu Xiao-Ning
Molecular determinants for subcellular localization of the severe acute respiratory syndrome coronavirus open reading frame 3b protein.
Journal of virology 2009;83(13):6631-40.
2009: Yin Qian; Lin Su-Chang; Lamothe Betty; Lu Miao; Lo Yu-Chih; Hura Gregory; Zheng Lixin; Rich Rebecca L; Campos Alejandro D; Myszka David G; Lenardo Michael J; Darnay Bryant G; Wu Hao
E2 interaction and dimerization in the crystal structure of TRAF6.
Nature structural & molecular biology 2009;16(6):658-66.
2009: Bidère Nicolas; Ngo Vu N; Lee Jeansun; Collins Cailin; Zheng Lixin; Wan Fengyi; Davis R Eric; Lenz Georg; Anderson D Eric; Arnoult Damien; Vazquez Aimé; Sakai Keiko; Zhang Jun; Meng Zhaojing; Veenstra Timothy D; Staudt Louis M; Lenardo Michael J
Casein kinase 1alpha governs antigen-receptor-induced NF-kappaB activation and human lymphoma cell survival.
Nature 2009;458(7234):92-6.
2009: Feng Carl G; Zheng Lixin; Lenardo Michael J; Sher Alan
Interferon-inducible immunity-related GTPase Irgm1 regulates IFN gamma-dependent host defense, lymphocyte survival and autophagy.
Autophagy 2009;5(2):232-4.
2009: Lenardo Michael J; McPhee Christina K; Yu Li
Autophagic cell death.
Methods in enzymology 2009;453():17-31.
2009: Prabhakar Madhavi; Lenardo Michael J
Human genetic approaches to diseases of lymphocyte activation.
Immunologic research 2009;43(1-3):8-14.
2008: Feng Carl G; Zheng Lixin; Jankovic Dragana; Báfica André; Cannons Jennifer L; Watford Wendy T; Chaussabel Damien; Hieny Sara; Caspar Patricia; Schwartzberg Pamela L; Lenardo Michael J; Sher Alan
The immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-gamma-induced cell death.
Nature immunology 2008;9(11):1279-87.
2008: Chun Hyung J; Ali Ziad A; Kojima Yoko; Kundu Ramendra K; Sheikh Ahmad Y; Agrawal Rani; Zheng Lixin; Leeper Nicholas J; Pearl Nathan E; Patterson Andrew J; Anderson Joshua P; Tsao Philip S; Lenardo Michael J; Ashley Euan A; Quertermous Thomas
Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis.
The Journal of clinical investigation 2008;118(10):3343-54.
2008: Yu Li; Strandberg Lindsey; Lenardo Michael J
The selectivity of autophagy and its role in cell death and survival.
Autophagy 2008;4(5):567-73.
2008: Freundt Eric C; Bidere Nicolas; Lenardo Michael J
A different TIPE of immune homeostasis.
Cell 2008;133(3):401-2.
2008: Su Helen C; Lenardo Michael J
Genetic defects of apoptosis and primary immunodeficiency.
Immunology and allergy clinics of North America 2008;28(2):329-51, ix.
2008: Snow Andrew L; Oliveira João B; Zheng Lixin; Dale Janet K; Fleisher Thomas A; Lenardo Michael J
Critical role for BIM in T cell receptor restimulation-induced death.
Biology direct 2008;3():34.
2008: Bolton Diane L; Barnitz Robert A; Sakai Keiko; Lenardo Michael J
14-3-3 theta binding to cell cycle regulatory factors is enhanced by HIV-1 Vpr.
Biology direct 2008;3():17.
2008: Pandiyan Pushpa; Lenardo Michael J
The control of CD4+CD25+Foxp3+ regulatory T cell survival.
Biology direct 2008;3():6.
2007: Pandiyan Pushpa; Zheng Lixin; Ishihara Satoru; Reed Jennifer; Lenardo Michael J
CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells.
Nature immunology 2007;8(12):1353-62.
2007: Wan Fengyi; Anderson D Eric; Barnitz Robert A; Snow Andrew; Bidere Nicolas; Zheng Lixin; Hegde Vijay; Lam Lloyd T; Staudt Louis M; Levens David; Deutsch Walter A; Lenardo Michael J
Ribosomal protein S3: a KH domain subunit in NF-kappaB complexes that mediates selective gene regulation.
Cell 2007;131(5):927-39.
2007: Freundt Eric C; Czapiga Meggan; Lenardo Michael J
Photoconversion of Lysotracker Red to a green fluorescent molecule.
Cell research 2007;17(11):956-8.
2007: Bolton Diane L; Lenardo Michael J
Vpr cytopathicity independent of G2/M cell cycle arrest in human immunodeficiency virus type 1-infected CD4+ T cells.
Journal of virology 2007;81(17):8878-90.
2007: Oliveira João B; Bidère Nicolas; Niemela Julie E; Zheng Lixin; Sakai Keiko; Nix Cynthia P; Danner Robert L; Barb Jennifer; Munson Peter J; Puck Jennifer M; Dale Janet; Straus Stephen E; Fleisher Thomas A; Lenardo Michael J
NRAS mutation causes a human autoimmune lymphoproliferative syndrome.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(21):8953-8.
2007: Liu Zhihua; Lenardo Michael J
Reactive oxygen species regulate autophagy through redox-sensitive proteases.
Developmental cell 2007;12(4):484-5.
2007: Lemmers Bénédicte; Salmena Leonardo; Bidère Nicolas; Su Helen; Matysiak-Zablocki Elzbieta; Murakami Kiichi; Ohashi Pamela S; Jurisicova Andrea; Lenardo Michael; Hakem Razqallah; Hakem Anne
Essential role for caspase-8 in Toll-like receptors and NFkappaB signaling.
The Journal of biological chemistry 2007;282(10):7416-23.
2007: Cerutti Elisa; Campagnoli Maria F; Ferretti Massimo; Garelli Emanuela; Crescenzio Nicoletta; Rosolen Angelo; Chiocchetti Annalisa; Lenardo Michael J; Ramenghi Ugo; Dianzani Umberto
Co-inherited mutations of Fas and caspase-10 in development of the autoimmune lymphoproliferative syndrome.
BMC immunology 2007;8():28.
2007: Bi Lilia L; Pan George; Atkinson T Prescott; Zheng Lixin; Dale Janet K; Makris Christopher; Reddy Vishnu; McDonald Jay M; Siegel Richard M; Puck Jennifer M; Lenardo Michael J; Straus Stephen E
Dominant inhibition of Fas ligand-mediated apoptosis due to a heterozygous mutation associated with autoimmune lymphoproliferative syndrome (ALPS) Type Ib.
BMC medical genetics 2007;8():41.
2006: Zheng Lixin; Lenardo Michael
T helper 2 cells' preferred way to die.
Immunity 2006;25(2):187-8.
2006: Bidère Nicolas; Snow Andrew L; Sakai Keiko; Zheng Lixin; Lenardo Michael J
Caspase-8 regulation by direct interaction with TRAF6 in T cell receptor-induced NF-kappaB activation.
Current biology : CB 2006;16(16):1666-71.
2006: Zheng Lixin; Bidere Nicolas; Staudt David; Cubre Alan; Orenstein Jan; Chan Francis K; Lenardo Michael
Competitive control of independent programs of tumor necrosis factor receptor-induced cell death by TRADD and RIP1.
Molecular and cellular biology 2006;26(9):3505-13.
2006: Zhu Shigui; Hsu Amy P; Vacek Marla M; Zheng Lixin; Schäffer Alejandro A; Dale Janet K; Davis Joie; Fischer Roxanne E; Straus Stephen E; Boruchov Donna; Saulsbury Frank T; Lenardo Michael J; Puck Jennifer M
Genetic alterations in caspase-10 may be causative or protective in autoimmune lymphoproliferative syndrome.
Human genetics 2006;119(3):284-94.
2006: Yu Li; Wan Fengyi; Dutta Sudeshna; Welsh Sarah; Liu ZhiHua; Freundt Eric; Baehrecke Eric H; Lenardo Michael
Autophagic programmed cell death by selective catalase degradation.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(13):4952-7.
2006: Sakai Keiko; Dimas Joseph; Lenardo Michael J
The Vif and Vpr accessory proteins independently cause HIV-1-induced T cell cytopathicity and cell cycle arrest.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(9):3369-74.
2006: Bidère Nicolas; Su Helen C; Lenardo Michael J
Genetic disorders of programmed cell death in the immune system.
Annual review of immunology 2006;24():321-52.
2005: Yang Jin Kuk; Wang Liwei; Zheng Lixin; Wan Fengyi; Ahmed Misonara; Lenardo Michael J; Wu Hao
Crystal structure of MC159 reveals molecular mechanism of DISC assembly and FLIP inhibition.
Molecular cell 2005;20(6):939-49.
2005: Clancy Lauren; Mruk Karen; Archer Kristina; Woelfel Melissa; Mongkolsapaya Juthathip; Screaton Gavin; Lenardo Michael J; Chan Francis Ka-Ming
Preligand assembly domain-mediated ligand-independent association between TRAIL receptor 4 (TR4) and TR2 regulates TRAIL-induced apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(50):18099-104.
2005: Freundt Eric C; Lenardo Michael J
Interfering with interferons: Hepatitis C virus counters innate immunity.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(49):17539-40.
2005: Deng Guo-Min; Zheng Lixin; Chan Francis Ka-Ming; Lenardo Michael
Amelioration of inflammatory arthritis by targeting the pre-ligand assembly domain of tumor necrosis factor receptors.
Nature medicine 2005;11(10):1066-72.
2005: Roesler Joachim; Izquierdo Jose-Maria; Ryser Martin; Rösen-Wolff Angela; Gahr Manfred; Valcarcel Juan; Lenardo Michael J; Zheng Lixin
Haploinsufficiency, rather than the effect of an excessive production of soluble CD95 (CD95{Delta}TM), is the basis for ALPS Ia in a family with duplicated 3' splice site AG in CD95 intron 5 on one allele.
Blood 2005;106(5):1652-9.
2005: Speirs Christina; van Nimwegen Erik; Bolton Diane; Zavolan Mihaela; Duvall Melody; Angleman Sara; Siegel Richard; Perelson Alan S; Lenardo Michael J
Analysis of human immunodeficiency virus cytopathicity by using a new method for quantitating viral dynamics in cell culture.
Journal of virology 2005;79(7):4025-32.
2005: Su Helen; Bidère Nicolas; Zheng Lixin; Cubre Alan; Sakai Keiko; Dale Janet; Salmena Leonardo; Hakem Razqallah; Straus Stephen; Lenardo Michael
Requirement for caspase-8 in NF-kappaB activation by antigen receptor.
Science (New York, N.Y.) 2005;307(5714):1465-8.
2004: Siegel Richard M; Muppidi Jagan R; Sarker Malabika; Lobito Adrian; Jen Melinda; Martin David; Straus Stephen E; Lenardo Michael J
SPOTS: signaling protein oligomeric transduction structures are early mediators of death receptor-induced apoptosis at the plasma membrane.
The Journal of cell biology 2004;167(4):735-44.
2004: Legembre Patrick; Barnhart Bryan C; Zheng Lixin; Vijayan Shrijay; Straus Stephen E; Puck Jennifer; Dale Janet K; Lenardo Michael; Peter Marcus E
Induction of apoptosis and activation of NF-kappaB by CD95 require different signalling thresholds.
EMBO reports 2004;5(11):1084-9.
2004: Yu Li; Lenardo Michael J; Baehrecke Eric H
Autophagy and caspases: a new cell death program.
Cell cycle (Georgetown, Tex.) 2004;3(9):1124-6.
2004: Su Helen; Bidere Nicolas; Lenardo Michael
Another fork in the road: Foxo3a regulates NF-kappaB activation.
Immunity 2004;21(2):133-4.
2004: Yu Li; Alva Ajjai; Su Helen; Dutt Parmesh; Freundt Eric; Welsh Sarah; Baehrecke Eric H; Lenardo Michael J
Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8.
Science (New York, N.Y.) 2004;304(5676):1500-2.
2004: Lobito Adrian A; Lopes Marcela F; Lenardo Michael J
Ectopic T cell receptor expression causes B cell immunodeficiency in transgenic mice.
European journal of immunology 2004;34(3):890-8.
2004: Kanno Tomohiko; Kanno Yuka; Siegel Richard M; Jang Moon Kyoo; Lenardo Michael J; Ozato Keiko
Selective recognition of acetylated histones by bromodomain proteins visualized in living cells.
Molecular cell 2004;13(1):33-43.
2003: Chan Francis Ka-Ming; Shisler Joanna; Bixby Jacqueline G; Felices Martin; Zheng Lixin; Appel Michael; Orenstein Jan; Moss Bernard; Lenardo Michael J
A role for tumor necrosis factor receptor-2 and receptor-interacting protein in programmed necrosis and antiviral responses.
The Journal of biological chemistry 2003;278(51):51613-21.
2003: Yu Li; Lenardo Michael J
Immunology. The paracaspase connection.
Science (New York, N.Y.) 2003;302(5650):1515-6.
2003: Miagkov Alexei; Lobito Adrain A; Yang Bingzhi; Lopes Marcela F; Adams Robert N; Palardy Gregory R; Johnson Michele M; McFarland HughI; Lenardo Michael J; Drachman Daniel B
Production and characterization of a T cell receptor transgenic mouse recognizing the immunodominant epitope of the Torpedo californica acetylcholine receptor.
Annals of the New York Academy of Sciences 2003;998():379-83.
2003: Tibbetts Michael D; Zheng Lixin; Lenardo Michael J
The death effector domain protein family: regulators of cellular homeostasis.
Nature immunology 2003;4(5):404-9.
2003: Yamagoe Satoshi; Kanno Tomohiko; Kanno Yuka; Sasaki Shigakazu; Siegel Richard M; Lenardo Michael J; Humphrey Glen; Wang Yonghong; Nakatani Yoshihiro; Howard Bruce H; Ozato Keiko
Interaction of histone acetylases and deacetylases in vivo.
Molecular and cellular biology 2003;23(3):1025-33.
2003: Lenardo Michael J
Molecular regulation of T lymphocyte homeostasis in the healthy and diseased immune system.
Immunologic research 2003;27(2-3):387-98.
2002: Siegel Richard M; Lenardo Michael J
Apoptosis signaling pathways.
Current protocols in immunology / edited by John E. Coligan ... [et al.] 2002;Chapter 11():Unit 11.9C.
2002: Chun Hyung J; Zheng Lixin; Ahmad Manzoor; Wang Jin; Speirs Christina K; Siegel Richard M; Dale Janet K; Puck Jennifer; Davis Joie; Hall Craig G; Skoda-Smith Suzanne; Atkinson T Prescott; Straus Stephen E; Lenardo Michael J
Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency.
Nature 2002;419(6905):395-9.
2002: Garvey Tara; Bertin John; Siegel Richard; Lenardo Michael; Cohen Jeffrey
The death effector domains (DEDs) of the molluscum contagiosum virus MC159 v-FLIP protein are not functionally interchangeable with each other or with the DEDs of caspase-8.
Virology 2002;300(2):217-25.
2002: Siegel Richard M; Lenardo Michael J
Apoptosis signaling pathways.
Current protocols in cytometry / editorial board, J. Paul Robinson, managing editor ... [et al.] 2002;Chapter 7():Unit 7.18.
2002: Lobito Adrian A; Yang Bingzhi; Lopes Marcela F; Miagkov Alexei; Adams Robert N; Palardy Gregory R; Johnson Michele M; McFarland Hugh I; Recher Michael; Drachman Daniel B; Lenardo Michael J
T cell receptor transgenic mice recognizing the immunodominant epitope of the Torpedo californica acetylcholine receptor.
European journal of immunology 2002;32(7):2055-67.
2002: Bolton Diane L; Hahn Beom-Ik; Park Eugenia A; Lehnhoff Laura L; Hornung Felicita; Lenardo Michael J
Death of CD4(+) T-cell lines caused by human immunodeficiency virus type 1 does not depend on caspases or apoptosis.
Journal of virology 2002;76(10):5094-107.
2002: Lenardo Michael J; Angleman Sara B; Bounkeua Viengngeun; Dimas Joseph; Duvall Melody G; Graubard Moses B; Hornung Felicita; Selkirk Marianne C; Speirs Christina K; Trageser Carol; Orenstein Jan O; Bolton Diane L
Cytopathic killing of peripheral blood CD4(+) T lymphocytes by human immunodeficiency virus type 1 appears necrotic rather than apoptotic and does not require env.
Journal of virology 2002;76(10):5082-93.
2002: Garvey Tara L; Bertin John; Siegel Richard M; Wang G H; Lenardo Michael J; Cohen Jeffrey I
Binding of FADD and caspase-8 to molluscum contagiosum virus MC159 v-FLIP is not sufficient for its antiapoptotic function.
Journal of virology 2002;76(2):697-706.
2001: Wang J; Chun H J; Wong W; Spencer D M; Lenardo M J
Caspase-10 is an initiator caspase in death receptor signaling.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(24):13884-8.
2001: Bleesing J J; Brown M R; Straus S E; Dale J K; Siegel R M; Johnson M; Lenardo M J; Puck J M; Fleisher T A
Immunophenotypic profiles in families with autoimmune lymphoproliferative syndrome.
Blood 2001;98(8):2466-73.
2001: Bleesing J J; Brown M R; Dale J K; Straus S E; Lenardo M J; Puck J M; Atkinson T P; Fleisher T A
TcR-alpha/beta(+) CD4(-)CD8(-) T cells in humans with the autoimmune lymphoproliferative syndrome express a novel CD45 isoform that is analogous to murine B220 and represents a marker of altered O-glycan biosynthesis.
Clinical immunology (Orlando, Fla.) 2001;100(3):314-24.
2001: Chan F K; Siegel R M; Zacharias D; Swofford R; Holmes K L; Tsien R Y; Lenardo M J
Fluorescence resonance energy transfer analysis of cell surface receptor interactions and signaling using spectral variants of the green fluorescent protein.
Cytometry 2001;44(4):361-8.
2001: Zheng L; Schickling O; Peter M E; Lenardo M J
The death effector domain-associated factor plays distinct regulatory roles in the nucleus and cytoplasm.
The Journal of biological chemistry 2001;276(34):31945-52.
2001: Siegel R M; Lenardo M J
To B or not to B: TNF family signaling in lymphocytes.
Nature immunology 2001;2(7):577-8.
2001: Straus S E; Jaffe E S; Puck J M; Dale J K; Elkon K B; Rösen-Wolff A; Peters A M; Sneller M C; Hallahan C W; Wang J; Fischer R E; Jackson C M; Lin A Y; Bäumler C; Siegert E; Marx A; Vaishnaw A K; Grodzicky T; Fleisher T A; Lenardo M J
The development of lymphomas in families with autoimmune lymphoproliferative syndrome with germline Fas mutations and defective lymphocyte apoptosis.
Blood 2001;98(1):194-200.
2001: Fleisher T A; Puck J M; Strober W; Dale J K; Lenardo M J; Siegel R M; Straus S E; Bleesing J J
The autoimmune lymphoproliferative syndrome. A disorder of human lymphocyte apoptosis.
Clinical reviews in allergy & immunology 2001;20(1):109-20.
2001: McFarland H I; Lobito A A; Johnson M M; Palardy G R; Yee C S; Jordan E K; Frank J A; Tresser N; Genain C P; Mueller J P; Matis L A; Lenardo M J
Effective antigen-specific immunotherapy in the marmoset model of multiple sclerosis.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(3):2116-21.
2001: Chun H J; Lenardo M J
Autoimmune lymphoproliferative syndrome: types I, II and beyond.
Advances in experimental medicine and biology 2001;490():49-57.
2001: Chamorro M; Czar M J; Debnath J; Cheng G; Lenardo M J; Varmus H E; Schwartzberg P L
Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk.
BMC immunology 2001;2():3.
2000: Siegel R M; Chan F K; Chun H J; Lenardo M J
The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity.
Nature immunology 2000;1(6):469-74.
2000: Siegel R M; Chan F K; Zacharias D A; Swofford R; Holmes K L; Tsien R Y; Lenardo M J
Measurement of molecular interactions in living cells by fluorescence resonance energy transfer between variants of the green fluorescent protein.
Science's STKE : signal transduction knowledge environment 2000;2000(38):pl1.
2000: Siegel R M; Frederiksen J K; Zacharias D A; Chan F K; Johnson M; Lynch D; Tsien R Y; Lenardo M J
Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations.
Science (New York, N.Y.) 2000;288(5475):2354-7.
2000: Chan F K; Chun H J; Zheng L; Siegel R M; Bui K L; Lenardo M J
A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling.
Science (New York, N.Y.) 2000;288(5475):2351-4.
2000: Hornung F; Scala G; Lenardo M J
TNF-alpha-induced secretion of C-C chemokines modulates C-C chemokine receptor 5 expression on peripheral blood lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(12):6180-7.
2000: Chan F K; Lenardo M J
A crucial role for p80 TNF-R2 in amplifying p60 TNF-R1 apoptosis signals in T lymphocytes.
European journal of immunology 2000;30(2):652-60.
2000: Wang J; Lobito A A; Shen F; Hornung F; Winoto A; Lenardo M J
Inhibition of Fas-mediated apoptosis by the B cell antigen receptor through c-FLIP.
European journal of immunology 2000;30(1):155-63.
1999: Wang J; Zheng L; Lobito A; Chan F K; Dale J; Sneller M; Yao X; Puck J M; Straus S E; Lenardo M J
Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II.
Cell 1999;98(1):47-58.
1999: Jordan E K; McFarland H I; Lewis B K; Tresser N; Gates M A; Johnson M; Lenardo M; Matis L A; McFarland H F; Frank J A
Serial MR imaging of experimental autoimmune encephalomyelitis induced by human white matter or by chimeric myelin-basic and proteolipid protein in the common marmoset.
AJNR. American journal of neuroradiology 1999;20(6):965-76.
1999: Jiang D; Zheng L; Lenardo M J
Caspases in T-cell receptor-induced thymocyte apoptosis.
Cell death and differentiation 1999;6(5):402-11.
1999: Schaeffer E M; Debnath J; Yap G; McVicar D; Liao X C; Littman D R; Sher A; Varmus H E; Lenardo M J; Schwartzberg P L
Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity.
Science (New York, N.Y.) 1999;284(5414):638-41.
1999: Martin D A; Zheng L; Siegel R M; Huang B; Fisher G H; Wang J; Jackson C E; Puck J M; Dale J; Straus S E; Peter M E; Krammer P H; Fesik S; Lenardo M J
Defective CD95/APO-1/Fas signal complex formation in the human autoimmune lymphoproliferative syndrome, type Ia.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(8):4552-7.
1999: Straus S E; Sneller M; Lenardo M J; Puck J M; Strober W
An inherited disorder of lymphocyte apoptosis: the autoimmune lymphoproliferative syndrome.
Annals of internal medicine 1999;130(7):591-601.
1999: Jackson C E; Fischer R E; Hsu A P; Anderson S M; Choi Y; Wang J; Dale J K; Fleisher T A; Middelton L A; Sneller M C; Lenardo M J; Straus S E; Puck J M
Autoimmune lymphoproliferative syndrome with defective Fas: genotype influences penetrance.
American journal of human genetics 1999;64(4):1002-14.
1999: Dudley E; Hornung F; Zheng L; Scherer D; Ballard D; Lenardo M
NF-kappaB regulates Fas/APO-1/CD95- and TCR- mediated apoptosis of T lymphocytes.
European journal of immunology 1999;29(3):878-86.
1999: McFarland H I; Lobito A A; Johnson M M; Nyswaner J T; Frank J A; Palardy G R; Tresser N; Genain C P; Mueller J P; Matis L A; Lenardo M J
Determinant spreading associated with demyelination in a nonhuman primate model of multiple sclerosis.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(4):2384-90.
1999: Debnath J; Chamorro M; Czar M J; Schaeffer E M; Lenardo M J; Varmus H E; Schwartzberg P L
rlk/TXK encodes two forms of a novel cysteine string tyrosine kinase activated by Src family kinases.
Molecular and cellular biology 1999;19(2):1498-507.
1999: Lenardo M; Chan K M; Hornung F; McFarland H; Siegel R; Wang J; Zheng L
Mature T lymphocyte apoptosis--immune regulation in a dynamic and unpredictable antigenic environment.
Annual review of immunology 1999;17():221-53.
1998: Infante A J; Britton H A; DeNapoli T; Middelton L A; Lenardo M J; Jackson C E; Wang J; Fleisher T; Straus S E; Puck J M
The clinical spectrum in a large kindred with autoimmune lymphoproliferative syndrome caused by a Fas mutation that impairs lymphocyte apoptosis.
The Journal of pediatrics 1998;133(5):629-33.
1998: Lim M S; Straus S E; Dale J K; Fleisher T A; Stetler-Stevenson M; Strober W; Sneller M C; Puck J M; Lenardo M J; Elenitoba-Johnson K S; Lin A Y; Raffeld M; Jaffe E S
Pathological findings in human autoimmune lymphoproliferative syndrome.
The American journal of pathology 1998;153(5):1541-50.
1998: Combadière B; Reis e Sousa C; Trageser C; Zheng L X; Kim C R; Lenardo M J
Differential TCR signaling regulates apoptosis and immunopathology during antigen responses in vivo.
Immunity 1998;9(3):305-13.
1998: Siegel R M; Martin D A; Zheng L; Ng S Y; Bertin J; Cohen J; Lenardo M J
Death-effector filaments: novel cytoplasmic structures that recruit caspases and trigger apoptosis.
The Journal of cell biology 1998;141(5):1243-53.
1998: Rasper D M; Vaillancourt J P; Hadano S; Houtzager V M; Seiden I; Keen S L; Tawa P; Xanthoudakis S; Nasir J; Martindale D; Koop B F; Peterson E P; Thornberry N A; Huang J; MacPherson D P; Black S C; Hornung F; Lenardo M J; Hayden M R; Roy S; Nicholson D W
Cell death attenuation by 'Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex.
Cell death and differentiation 1998;5(4):271-88.
1998: Martin D A; Siegel R M; Zheng L; Lenardo M J
Membrane oligomerization and cleavage activates the caspase-8 (FLICE/MACHalpha1) death signal.
The Journal of biological chemistry 1998;273(8):4345-9.
1998: Combadière B; Reis e Sousa C; Germain R N; Lenardo M J
Selective induction of apoptosis in mature T lymphocytes by variant T cell receptor ligands.
The Journal of experimental medicine 1998;187(3):349-55.
1998: Zheng L; Trageser C L; Willerford D M; Lenardo M J
T cell growth cytokines cause the superinduction of molecules mediating antigen-induced T lymphocyte death.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(2):763-9.
1998: Martin D A; Combadiere B; Hornung F; Jiang D; McFarland H; Siegel R; Trageser C; Wang J; Zheng L; Lenardo M J
Molecular genetic studies in lymphocyte apoptosis and human autoimmunity.
Novartis Foundation symposium 1998;215():73-82; discussion 82-91.
1997: Wang J; Lenardo M J
Molecules involved in cell death and peripheral tolerance.
Current opinion in immunology 1997;9(6):818-25.
1997: Hornung F; Zheng L; Lenardo M J
Maintenance of clonotype specificity in CD95/Apo-1/Fas-mediated apoptosis of mature T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(8):3816-22.
1997: Wang J; Lenardo M J
Essential lymphocyte function associated 1 (LFA-1): intercellular adhesion molecule interactions for T cell-mediated B cell apoptosis by Fas/APO-1/CD95.
The Journal of experimental medicine 1997;186(7):1171-6.
1997: Yin L; Schwartzberg P; Scharton-Kersten T M; Staudt L; Lenardo M
Immune responses in mice deficient in Ly-GDI, a lymphoid-specific regulator of Rho GTPases.
Molecular immunology 1997;34(6):481-91.
1997: Bertin J; Armstrong R C; Ottilie S; Martin D A; Wang Y; Banks S; Wang G H; Senkevich T G; Alnemri E S; Moss B; Lenardo M J; Tomaselli K J; Cohen J I
Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(4):1172-6.
1997: Sneller M C; Wang J; Dale J K; Strober W; Middelton L A; Choi Y; Fleisher T A; Lim M S; Jaffe E S; Puck J M; Lenardo M J; Straus S E
Clincal, immunologic, and genetic features of an autoimmune lymphoproliferative syndrome associated with abnormal lymphocyte apoptosis.
Blood 1997;89(4):1341-8.
1996: Boehme S A; Lenardo M J
TCR-mediated death of mature T lymphocytes occurs in the absence of p53.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(11):4075-8.
1996: Combadière B; Freedman M; Chen L; Shores E W; Love P; Lenardo M J
Qualitative and quantitative contributions of the T cell receptor zeta chain to mature T cell apoptosis.
The Journal of experimental medicine 1996;183(5):2109-17.
1996: Zúñiga-Pflücker J C; Lenardo M J
Regulation of thymocyte development from immature progenitors.
Current opinion in immunology 1996;8(2):215-24.
1996: Jiang D; Lenardo M J; Zúñiga-Pflücker J C
p53 prevents maturation to the CD4+CD8+ stage of thymocyte differentiation in the absence of T cell receptor rearrangement.
The Journal of experimental medicine 1996;183(4):1923-8.
1996: Fisher G H; Lenardo M J; Zuniga-Pflucker J C
Synergy between T cell Receptor and Fas (CD95/APO-1) signaling in mouse thymocyte death.
Cellular immunology 1996;169(1):99-106.
1996: Lenardo M J
Fas and the art of lymphocyte maintenance.
The Journal of experimental medicine 1996;183(3):721-4.
1996: Racke M K; Critchfield J M; Quigley L; Cannella B; Raine C S; McFarland H F; Lenardo M J
Intravenous antigen administration as a therapy for autoimmune demyelinating disease.
Annals of neurology 1996;39(1):46-56.
1996: Zheng L; Fisher G; Combadiere B; Hornung F; Martin D; Pelfrey C; Wang J; Lenardo M
Mature T lymphocyte apoptosis in the healthy and diseased immune system.
Advances in experimental medicine and biology 1996;406():229-39.
1995: Nye S H; Pelfrey C M; Burkwit J J; Voskuhl R R; Lenardo M J; Mueller J P
Purification of immunologically active recombinant 21.5 kDa isoform of human myelin basic protein.
Molecular immunology 1995;32(14-15):1131-41.
1995: Boehme S A; Zheng L; Lenardo M J
Analysis of the CD4 coreceptor and activation-induced costimulatory molecules in antigen-mediated mature T lymphocyte death.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(4):1703-12.
1995: Zúñiga-Pflücker J C; Di J; Lenardo M J
Requirement for TNF-alpha and IL-1 alpha in fetal thymocyte commitment and differentiation.
Science (New York, N.Y.) 1995;268(5219):1906-9.
1995: Fisher G H; Rosenberg F J; Straus S E; Dale J K; Middleton L A; Lin A Y; Strober W; Lenardo M J; Puck J M
Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome.
Cell 1995;81(6):935-46.
1995: Pelfrey C M; Tranquill L R; Boehme S A; McFarland H F; Lenardo M J
Two mechanisms of antigen-specific apoptosis of myelin basic protein (MBP)-specific T lymphocytes derived from multiple sclerosis patients and normal individuals.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(11):6191-202.
1995: Critchfield J M; Lenardo M J
Antigen-induced programmed T cell death as a new approach to immune therapy.
Clinical immunology and immunopathology 1995;75(1):13-9.
1995: Hu Q; Davidson D; Schwartzberg P L; Macchiarini F; Lenardo M J; Bluestone J A; Matis L A
Identification of Rlk, a novel protein tyrosine kinase with predominant expression in the T cell lineage.
The Journal of biological chemistry 1995;270(4):1928-34.
1995: Critchfield J M; Zúñiga-Pflücker J C; Lenardo M J
Parameters controlling the programmed death of mature mouse T lymphocytes in high-dose suppression.
Cellular immunology 1995;160(1):71-8.
1995: Lenardo M J; Boehme S; Chen L; Combadiere B; Fisher G; Freedman M; McFarland H; Pelfrey C; Zheng L
Autocrine feedback death and the regulation of mature T lymphocyte antigen responses.
International reviews of immunology 1995;13(2):115-34.
1995: McFarland H I; Critchfield J M; Racke M K; Mueller J P; Nye S H; Boehme S A; Lenardo M J
Amelioration of autoimmune reactions by antigen-induced apoptosis of T cells.
Advances in experimental medicine and biology 1995;383():157-66.
1994: Zúñiga-Pflücker J C; Jiang D; Schwartzberg P L; Lenardo M J
Sublethal gamma-radiation induces differentiation of CD4-/CD8- into CD4+/CD8+ thymocytes without T cell receptor beta rearrangement in recombinase activation gene 2-/- mice.
The Journal of experimental medicine 1994;180(4):1517-21.
1994: Critchfield J M; Racke M K; Zúñiga-Pflücker J C; Cannella B; Raine C S; Goverman J; Lenardo M J
T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis.
Science (New York, N.Y.) 1994;263(5150):1139-43.
1994: Zheng L; Boehme S A; Critchfield J M; Zuniga-Pflucker J C; Freedman M; Lenardo M J
Immunological tolerance by antigen-induced apoptosis of mature T lymphocytes.
Advances in experimental medicine and biology 1994;365():81-9.
1993: Bruhn K W; Nelms K; Boulay J L; Paul W E; Lenardo M J
Molecular dissection of the mouse interleukin-4 promoter.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(20):9707-11.
1993: Grilli M; Chen-Tran A; Lenardo M J
Tumor necrosis factor alpha mediates a T cell receptor-independent induction of the gene regulatory factor NF-kappa B in T lymphocytes.
Molecular immunology 1993;30(14):1287-94.
1993: Zúñiga-Pflücker J C; Schwartz H L; Lenardo M J
Gene transcription in differentiating immature T cell receptor(neg) thymocytes resembles antigen-activated mature T cells.
The Journal of experimental medicine 1993;178(4):1139-49.
1993: Boehme S A; Lenardo M J
Ligand-induced apoptosis of mature T lymphocytes (propriocidal regulation) occurs at distinct stages of the cell cycle.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1993;7 Suppl 2():S45-9.
1993: Boehme S A; Lenardo M J
Propriocidal apoptosis of mature T lymphocytes occurs at S phase of the cell cycle.
European journal of immunology 1993;23(7):1552-60.
1993: Kuang A A; Novak K D; Kang S M; Bruhn K; Lenardo M J
Interaction between NF-kappa B- and serum response factor-binding elements activates an interleukin-2 receptor alpha-chain enhancer specifically in T lymphocytes.
Molecular and cellular biology 1993;13(4):2536-45.
1993: Grilli M; Chiu J J; Lenardo M J
NF-kappa B and Rel: participants in a multiform transcriptional regulatory system.
International review of cytology 1993;143():1-62.
1992: Kang S M; Beverly B; Tran A C; Brorson K; Schwartz R H; Lenardo M J
Transactivation by AP-1 is a molecular target of T cell clonal anergy.
Science (New York, N.Y.) 1992;257(5073):1134-8.
1992: Kang S M; Tsang W; Doll S; Scherle P; Ko H S; Tran A C; Lenardo M J; Staudt L M
Induction of the POU domain transcription factor Oct-2 during T-cell activation by cognate antigen.
Molecular and cellular biology 1992;12(7):3149-54.
1992: Beverly B; Kang S M; Lenardo M J; Schwartz R H
Reversal of in vitro T cell clonal anergy by IL-2 stimulation.
International immunology 1992;4(6):661-71.
1992: Kang S M; Tran A C; Grilli M; Lenardo M J
NF-kappa B subunit regulation in nontransformed CD4+ T lymphocytes.
Science (New York, N.Y.) 1992;256(5062):1452-6.
1991: Brorson K A; Beverly B; Kang S M; Lenardo M; Schwartz R H
Transcriptional regulation of cytokine genes in nontransformed T cells. Apparent constitutive signals in run-on assays can be caused by repeat sequences.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(10):3601-9.
1991: Staudt L M; Lenardo M J
Immunoglobulin gene transcription.
Annual review of immunology 1991;9():373-98.

Sign-in to see more

Sign-in free and Explore the Exciting World of BiomedExperts:

NetworkView

Michael Lenardo

Research Profile (preview)

Chemicals & Drugs

Living Beings

Anatomy

Physiology

Disorders

Concepts & Ideas

Network (preview)

Publications

Sign in free and see...

Visualized networks:

GeoTargeted Searches:

Research Profiles:

Geonetwork of Michael Lenardo (preview)

All Publications