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Wayne Lencer

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Chemicals & Drugs

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TOP 3
Kristi Baker; Edda Fiebiger; Wayne I Lencer; Timo Rath; Richard S Blumberg
Cross-presentation of IgG-containing immune complexes.
Timo Rath; Derry C Roopenian; Masaru Yoshida; Kristi Baker; Edda Fiebiger; Kanna Kobayashi; Timothy T Kuo; Wayne I Lencer; Shuo-Wang Qiao; Richard S Blumberg
The immunologic functions of the neonatal Fc receptor for IgG.
Daniel J-F Chinnapen; Catherine E Costello; Ludovic D'Auria; Kimberly R Drake; Wan-Ting Hsieh; Minchul Kang; Lydia Kaoutzani; Anne K Kenworthy; Ramiro H Massol; Hyejung Park; David E Saslowsky; Yvonne M te Welscher; M David Ullman; Jessica S Wagner; Tobias Baumgart; Thomas Benjamin; Eelke Brandsma; Wayne I Lencer
Lipid sorting by ceramide structure from plasma membrane to ER for the cholera toxin receptor ganglioside GM1.

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All Publications

2013: Kristi Baker; Edda Fiebiger; Wayne I Lencer; Timo Rath; Richard S Blumberg
Cross-presentation of IgG-containing immune complexes.
Cellular and molecular life sciences : CMLS 2013;70(8):1319-34.
2013: Timo Rath; Derry C Roopenian; Masaru Yoshida; Kristi Baker; Edda Fiebiger; Kanna Kobayashi; Timothy T Kuo; Wayne I Lencer; Shuo-Wang Qiao; Richard S Blumberg
The immunologic functions of the neonatal Fc receptor for IgG.
Journal of clinical immunology 2013;33 Suppl 1():S9-17.
2012: Daniel J-F Chinnapen; Catherine E Costello; Ludovic D'Auria; Kimberly R Drake; Wan-Ting Hsieh; Minchul Kang; Lydia Kaoutzani; Anne K Kenworthy; Ramiro H Massol; Hyejung Park; David E Saslowsky; Yvonne M te Welscher; M David Ullman; Jessica S Wagner; Tobias Baumgart; Thomas Benjamin; Eelke Brandsma; Wayne I Lencer
Lipid sorting by ceramide structure from plasma membrane to ER for the cholera toxin receptor ganglioside GM1.
Developmental cell 2012;23(3):573-86.
2012: Michael G Jobling; Wendy R Kam; Wayne I Lencer; Zhijie Yang; Randall K Holmes
A single native ganglioside GM1-binding site is sufficient for cholera toxin to bind to cells and complete the intoxication pathway.
mBio 2012;3(6):.
2012: Jin A Cho; Wayne I Lencer; Emil Aamar; Daniel J-F Chinnapen; Yvonne M te Welscher; Ramiro Massol
Insights on the trafficking and retro-translocation of glycosphingolipid-binding bacterial toxins.
Frontiers in cellular and infection microbiology 2012;2():51.
2011: Wayne I Lencer; Ulrich H von Andrian
Eliciting mucosal immunity.
The New England journal of medicine 2011;365(12):1151-3.
2011: Yasunori Uchida; Yasuo Uchiyama; Soichi Wakatsuki; Daniel Chinnapen; Junya Hasegawa; Shun-ichiro Iemura; Takao Inoue; Ryuichi Kato; Masato Koike; Ryusuke Kuwahara; Wayne I Lencer; Ryo Misaki; Eiji Miyoshi; Kojiro Mukai; Takatoshi Nakagawa; Tohru Natsume; Kiyotaka Nishikawa; Seiji Okazaki; David Sheff; Tomohiko Taguchi; Naoyuki Taniguchi; Hiroyuki Arai
Intracellular phosphatidylserine is essential for retrograde membrane traffic through endosomes.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(38):15846-51.
2011: Wayne I Lencer; Rodney K Tweten
To translocate or not: that is the problem.
Cell host & microbe 2011;10(3):179-80.
2011: Kristi Baker; Jan-Terje Andersen; Victoria G Aveson; Zhangguo Chen; Colin de Haar; Edda Fiebiger; Timothy T Kuo; Wayne I Lencer; Barbara Platzer; Shuo-Wang Qiao; Inger Sandlie; Richard S Blumberg
Neonatal Fc receptor for IgG (FcRn) regulates cross-presentation of IgG immune complexes by CD8-CD11b+ dendritic cells.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(24):9927-32.
2011: Vandana Gupta; Genri Kawahara; Stacey R Gundry; Aye T Chen; Wayne I Lencer; Yi Zhou; Leonard I Zon; Louis Kunkel; Alan H Beggs
The zebrafish dag1 mutant: a novel genetic model for dystroglycanopathies.
Human molecular genetics 2011;20(9):1712-25.
2011: Flávia Nery; Mitsuo Tagaya; Bakhos A Tannous; Qiuyan Wang; Uzma Yaqub; Yihong Ye; Ioanna A Armata; Guy A Caldwell; Kim A Caldwell; Pan Chen; Jin A Cho; Cintia Carla da Hora; Jonathan E Farley; Christine Klein; Wayne I Lencer; Xandra O Breakefield
TorsinA participates in endoplasmic reticulum-associated degradation.
Nature communications 2011;2():393.
2010: David E Saslowsky; Jin Ah Cho; Himani Chinnapen; Ramiro H Massol; Daniel J-F Chinnapen; Jessica S Wagner; Heidi E De Luca; Wendy Kam; Barry H Paw; Wayne I Lencer
Intoxication of zebrafish and mammalian cells by cholera toxin depends on the flotillin/reggie proteins but not Derlin-1 or -2.
The Journal of clinical investigation 2010;120(12):4399-4409.
2010: Timothy T Kuo; Kristi Baker; Masaru Yoshida; Shuo-Wang Qiao; Victoria G Aveson; Wayne I Lencer; Richard S Blumberg
Neonatal Fc receptor: from immunity to therapeutics.
Journal of clinical immunology 2010;30(6):777-89.
2010: Joshua C Eby; William P Ciesla; Wendy Hamman; Gina M Donato; Raymond J Pickles; Erik L Hewlett; Wayne I Lencer
Selective translocation of the Bordetella pertussis adenylate cyclase toxin across the basolateral membranes of polarized epithelial cells.
The Journal of biological chemistry 2010;285(14):10662-70.
2010: Naomi L B Wernick; Daniel J-F Chinnapen; Jin Ah Cho; Wayne I Lencer
Cholera toxin: an intracellular journey into the cytosol by way of the endoplasmic reticulum.
Toxins 2010;2(3):310-25.
2010: Naomi L B Wernick; Heidi De Luca; Wendy R Kam; Wayne I Lencer
N-terminal extension of the cholera toxin A1-chain causes rapid degradation after retrotranslocation from endoplasmic reticulum to cytosol.
The Journal of biological chemistry 2010;285(9):6145-52.
2010: Vincent C Tam; Masato Suzuki; Margaret Coughlin; David Saslowsky; Kuntal Biswas; Wayne I Lencer; Shah M Faruque; John J Mekalanos
Functional analysis of VopF activity required for colonization in Vibrio cholerae.
mBio 2010;1(5):.
2009: Kanna Kobayashi; Shuo-Wang Qiao; Masaru Yoshida; Kristi Baker; Wayne I Lencer; Richard S Blumberg
An FcRn-dependent role for anti-flagellin immunoglobulin G in pathogenesis of colitis in mice.
Gastroenterology 2009;137(5):1746-56.e1.
2009: Kristi Baker; Shuo-Wang Qiao; Timothy Kuo; Kanna Kobayashi; Masaru Yoshida; Wayne I Lencer; Richard S Blumberg
Immune and non-immune functions of the (not so) neonatal Fc receptor, FcRn.
Seminars in immunopathology 2009;31(2):223-36.
2009: Salit Tzaban; Ramiro H Massol; Elizabeth Yen; Wendy Hamman; Scott R Frank; Lynne A Lapierre; Steen H Hansen; James R Goldenring; Richard S Blumberg; Wayne I Lencer
The recycling and transcytotic pathways for IgG transport by FcRn are distinct and display an inherent polarity.
The Journal of cell biology 2009;185(4):673-84.
2009: Timothy T Kuo; Eric J de Muinck; Steven M Claypool; Masaru Yoshida; Takashi Nagaishi; Victoria G Aveson; Wayne I Lencer; Richard S Blumberg
N-Glycan Moieties in Neonatal Fc Receptor Determine Steady-state Membrane Distribution and Directional Transport of IgG.
The Journal of biological chemistry 2009;284(13):8292-300.
2009: David Saslowsky; Noriyuki Tanaka; Krishna P Reddy; Wayne I Lencer
Ceramide activates JNK to inhibit a cAMP-gated K+ conductance and Cl- secretion in intestinal epithelia.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(1):259-70.
2008: Wayne I Lencer
Patching a leaky intestine.
The New England journal of medicine 2008;359(5):526-8.
2008: Shuo-Wang Qiao; Kanna Kobayashi; Finn-Eirik Johansen; Ludvig M Sollid; Jan Terje Andersen; Edgar Milford; Derry C Roopenian; Wayne I Lencer; Richard S Blumberg
Dependence of antibody-mediated presentation of antigen on FcRn.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(27):9337-42.
2008: Anne A Wolf; Michael G Jobling; David Saslowsky; Eli Kern; Kimberly R Drake; Anne K Kenworthy; Randall K Holmes; Wayne I Lencer
Attenuated endocytosis and toxicity of a mutant cholera toxin with decreased ability to cluster ganglioside GM1 molecules.
Infection and immunity 2008;76(4):1476-84.
2008: Kaleena M Bernardi; Michele L Forster; Wayne I Lencer; Billy Tsai
Derlin-1 facilitates the retro-translocation of cholera toxin.
Molecular biology of the cell 2008;19(3):877-84.
2008: Takuhiro Matsumura; Yingji Jin; Yuko Kabumoto; Yuki Takegahara; Keiji Oguma; Wayne I Lencer; Yukako Fujinaga
The HA proteins of botulinum toxin disrupt intestinal epithelial intercellular junctions to increase toxin absorption.
Cellular microbiology 2008;10(2):355-64.
2008: David Saslowsky; Wayne I Lencer
Conversion of apical plasma membrane sphingomyelin to ceramide attenuates the intoxication of host cells by cholera toxin.
Cellular microbiology 2008;10(1):67-80.
2008: Bonny L Dickinson; Steven M Claypool; June A D'Angelo; Martha L Aiken; Nanda Venu; Elizabeth H Yen; Jessica S Wagner; Jason A Borawski; Amy T Pierce; Robert Hershberg; Richard S Blumberg; Wayne I Lencer
Ca2+-dependent calmodulin binding to FcRn affects immunoglobulin G transport in the transcytotic pathway.
Molecular biology of the cell 2008;19(1):414-23.
2007: Shuo-Wang Qiao; Wayne I Lencer; Richard S Blumberg
How the controller is controlled - neonatal Fc receptor expression and immunoglobulin G homeostasis.
Immunology 2007;120(2):145-7.
2007: Daniel J-F Chinnapen; Himani Chinnapen; David Saslowsky; Wayne I Lencer
Rafting with cholera toxin: endocytosis and trafficking from plasma membrane to ER.
FEMS microbiology letters 2007;266(2):129-37.
2006: Masaru Yoshida; Atsuhiro Masuda; Timothy T Kuo; Kanna Kobayashi; Steven Claypool; Tetsuya Takagawa; Hiromu Kutsumi; Takeshi Azuma; Wayne I Lencer; Richard S Blumberg
IgG transport across mucosal barriers by neonatal Fc receptor for IgG and mucosal immunity.
Springer seminars in immunopathology 2006;28(4):397-403.
2006: Masaru Yoshida; Kanna Kobayashi; Timothy T Kuo; Lynn Bry; Jonathan N Glickman; Steven Claypool; Arthur Kaser; Takashi Nagaishi; Darren E Higgins; Emiko Mizoguchi; Yoshio Wakatsuki; Derry C Roopenian; Atsushi Mizoguchi; Wayne I Lencer; Richard S Blumberg
Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria.
The Journal of clinical investigation 2006;116(8):2142-2151.
2006: Michele L Forster; Kelsey Sivick; Young-Nam Park; Peter Arvan; Wayne I Lencer; Billy Tsai
Protein disulfide isomerase-like proteins play opposing roles during retrotranslocation.
The Journal of cell biology 2006;173(6):853-9.
2006: Henry E Pelish; William Ciesla; Nori Tanaka; Krishna Reddy; Matthew D Shair; Tomas Kirchhausen; Wayne I Lencer
The Cdc42 inhibitor secramine B prevents cAMP-induced K+ conductance in intestinal epithelial cells.
Biochemical pharmacology 2006;71(12):1720-6.
2006: Le Shen; Eric D Black; Edwina D Witkowski; Wayne I Lencer; Vince Guerriero; Eveline E Schneeberger; Jerrold R Turner
Myosin light chain phosphorylation regulates barrier function by remodeling tight junction structure.
Journal of cell science 2006;119(Pt 10):2095-106.
2006: Heidi E De Luca; Wayne I Lencer
A biochemical method for tracking cholera toxin transport from plasma membrane to Golgi and endoplasmic reticulum.
Methods in molecular biology (Clifton, N.J.) 2006;341():127-39.
2005: Wayne I Lencer; David Saslowsky
Raft trafficking of AB5 subunit bacterial toxins.
Biochimica et biophysica acta 2005;1746(3):314-21.
2005: Richard S Blumberg; Wayne I Lencer
Antibodies in the breakdown lane.
Nature biotechnology 2005;23(10):1232-4.
2005: Lei Lu; Sameer Khan; Wayne I Lencer; W Allan Walker
Endocytosis of cholera toxin by human enterocytes is developmentally regulated.
American journal of physiology. Gastrointestinal and liver physiology 2005;289(2):G332-41.
2005: Michael Kothe; Yihong Ye; Jessica S Wagner; Heidi E De Luca; Eli Kern; Tom A Rapoport; Wayne I Lencer
Role of p97 AAA-ATPase in the retrotranslocation of the cholera toxin A1 chain, a non-ubiquitinated substrate.
The Journal of biological chemistry 2005;280(30):28127-32.
2005: Xiaoping Zhu; Junmin Peng; Daohong Chen; Xindong Liu; Lilin Ye; Hideki Iijima; Kumar Kadavil; Wayne I Lencer; Richard S Blumberg
Calnexin and ERp57 facilitate the assembly of the neonatal Fc receptor for IgG with beta 2-microglobulin in the endoplasmic reticulum.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(2):967-76.
2005: Wayne I Lencer
Signal transduction by bacterial proteins.
Journal of pediatric gastroenterology and nutrition 2005;40 Suppl 1():S33-4.
2005: Catrina M A Stirling; Bryan Charleston; Haru-Hisa Takamatsu; Steven Claypool; Wayne I Lencer; Richard S Blumberg; Thomas Wileman
Characterization of the porcine neonatal Fc receptor--potential use for trans-epithelial protein delivery.
Immunology 2005;114(4):542-53.
2005: Wayne I Lencer; Richard S Blumberg
A passionate kiss, then run: exocytosis and recycling of IgG by FcRn.
Trends in cell biology 2005;15(1):5-9.
2005: Joanna Gilbert; Jean Dahl; Cathy Riney; John You; Cunqi Cui; Randall Holmes; Wayne I Lencer; Thomas L Benjamin
Ganglioside GD1a restores infectibility to mouse cells lacking functional receptors for polyomavirus.
Journal of virology 2005;79(1):615-8.
2004: Kamran Badizadegan; Heidi E Wheeler; Yukako Fujinaga; Wayne I Lencer
Trafficking of cholera toxin-ganglioside GM1 complex into Golgi and induction of toxicity depend on actin cytoskeleton.
American journal of physiology. Cell physiology 2004;287(5):C1453-62.
2004: Ramiro Massol; Jakob E Larsen; Yukako Fujinaga; Wayne I Lencer; Tomas Kirchhausen
Cholera toxin toxicity does not require functional Arf6- and dynamin-dependent endocytic pathways.
Molecular biology of the cell 2004;15(8):3631-41.
2004: Alan J Bitonti; Jennifer A Dumont; Susan C Low; Robert T Peters; Keith E Kropp; Vito J Palombella; James M Stattel; Yichun Lu; Cristina Tan Hehir; Jeffrey J Song; Ana Maria Garcia; Neil E Simister; Gerburg M Spiekermann; Wayne I Lencer; Richard S Blumberg
Pulmonary delivery of an erythropoietin Fc fusion protein in non-human primates through an immunoglobulin transport pathway.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(26):9763-8.
2004: Masaru Yoshida; Steven Claypool; Jessica S Wagner; Emiko Mizoguchi; Atsushi Mizoguchi; Derry C Roopenian; Wayne I Lencer; Richard S Blumberg
Human neonatal Fc receptor mediates transport of IgG into luminal secretions for delivery of antigens to mucosal dendritic cells.
Immunity 2004;20(6):769-83.
2004: Yan Feng; Ashutosh P Jadhav; Chiara Rodighiero; Yukako Fujinaga; Tomas Kirchhausen; Wayne I Lencer
Retrograde transport of cholera toxin from the plasma membrane to the endoplasmic reticulum requires the trans-Golgi network but not the Golgi apparatus in Exo2-treated cells.
EMBO reports 2004;5(6):596-601.
2004: Patricia W Lin; Peter O Simon; Andrew T Gewirtz; Andrew S Neish; Andre J Ouellette; James L Madara; Wayne I Lencer
Paneth cell cryptdins act in vitro as apical paracrine regulators of the innate inflammatory response.
The Journal of biological chemistry 2004;279(19):19902-7.
2004: Paul A Rufo; Patricia W Lin; Adriana S A Andrade; Lianwei Jiang; Lucia E Rameh; Charles Flexner; Seth L Alper; Wayne I Lencer
Diarrhea-associated HIV-1 APIs potentiate muscarinic activation of Cl- secretion by T84 cells via prolongation of cytosolic Ca2+ signaling.
American journal of physiology. Cell physiology 2004;286(5):C998-C1008.
2004: Wayne I Lencer
Retrograde transport of cholera toxin into the ER of host cells.
International journal of medical microbiology : IJMM 2004;293(7-8):491-4.
2004: Steven Claypool; Bonny L Dickinson; Jessica S Wagner; Finn-Eirik Johansen; Nanda Venu; Jason A Borawski; Wayne I Lencer; Richard S Blumberg
Bidirectional transepithelial IgG transport by a strongly polarized basolateral membrane Fcgamma-receptor.
Molecular biology of the cell 2004;15(4):1746-59.
2003: Wayne I Lencer; Billy Tsai
The intracellular voyage of cholera toxin: going retro.
Trends in biochemical sciences 2003;28(12):639-45.
2003: Yukako Fujinaga; Anne A Wolf; Chiara Rodighiero; Heidi E Wheeler; Billy Tsai; Larry Allen; Michael G Jobling; Tom A Rapoport; Randall K Holmes; Wayne I Lencer
Gangliosides that associate with lipid rafts mediate transport of cholera and related toxins from the plasma membrane to endoplasmic reticulm.
Molecular biology of the cell 2003;14(12):4783-93.
2003: Billy Tsai; Joanna M Gilbert; Thilo Stehle; Wayne I Lencer; Thomas L Benjamin; Tom A Rapoport
Gangliosides are receptors for murine polyoma virus and SV40.
The EMBO journal 2003;22(17):4346-55.
2003: Alan S L Yu; Alissa H Enck; Wayne I Lencer; Eveline E Schneeberger
Claudin-8 expression in Madin-Darby canine kidney cells augments the paracellular barrier to cation permeation.
The Journal of biological chemistry 2003;278(19):17350-9.
2003: Uzma Shah; Bonny L Dickinson; Richard S Blumberg; Neil E Simister; Wayne I Lencer; W Allan Walker
Distribution of the IgG Fc receptor, FcRn, in the human fetal intestine.
Pediatric research 2003;53(2):295-301.
2002: Chiara Rodighiero; Billy Tsai; Tom A Rapoport; Wayne I Lencer
Role of ubiquitination in retro-translocation of cholera toxin and escape of cytosolic degradation.
EMBO reports 2002;3(12):1222-7.
2002: Xiaoping Zhu; Junmin Peng; Raktima Raychowdhury; Atsushi Nakajima; Wayne I Lencer; Richard S Blumberg
The heavy chain of neonatal Fc receptor for IgG is sequestered in endoplasmic reticulum by forming oligomers in the absence of beta2-microglobulin association.
The Biochemical journal 2002;367(Pt 3):703-14.
2002: Gerburg M Spiekermann; Patricia W Finn; E Sally Ward; Jennifer Dumont; Bonny L Dickinson; Richard S Blumberg; Wayne I Lencer
Receptor-mediated immunoglobulin G transport across mucosal barriers in adult life: functional expression of FcRn in the mammalian lung.
The Journal of experimental medicine 2002;196(3):303-10.
2002: Steven Claypool; Bonny L Dickinson; Masaru Yoshida; Wayne I Lencer; Richard S Blumberg
Functional reconstitution of human FcRn in Madin-Darby canine kidney cells requires co-expressed human beta 2-microglobulin.
The Journal of biological chemistry 2002;277(31):28038-50.
2002: Anne A Wolf; Yukako Fujinaga; Wayne I Lencer
Uncoupling of the cholera toxin-G(M1) ganglioside receptor complex from endocytosis, retrograde Golgi trafficking, and downstream signal transduction by depletion of membrane cholesterol.
The Journal of biological chemistry 2002;277(18):16249-56.
2002: Gang Yue; Didier Merlin; Michael Selsted; Wayne I Lencer; James L Madara; Douglas C. Eaton
Cryptdin 3 forms anion selective channels in cytoplasmic membranes of human embryonic kidney cells.
American journal of physiology. Gastrointestinal and liver physiology 2002;282(5):G757-65.
2002: Wayne I Lencer; Kim Barrett; Sean Colgan; Mitchell B Cohen; Christopher P Duggan; Milton Kotelchuck; Jon Rhoads
Research agenda for pediatric gastroenterology, hepatology and nutrition: secretion and diarrhea. Report of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition for the Children's Digestive Health and Nutrition Foundation.
Journal of pediatric gastroenterology and nutrition 2002;35 Suppl 3():S246-9.
2001: S Wimer-Mackin; Randall K Holmes; Anne A Wolf; Wayne I Lencer; Michael G Jobling
Characterization of receptor-mediated signal transduction by Escherichia coli type IIa heat-labile enterotoxin in the polarized human intestinal cell line T84.
Infection and immunity 2001;69(12):7205-12.
2001: Chiara Rodighiero; Yukako Fujinaga; Timothy R Hirst; Wayne I Lencer
A cholera toxin B-subunit variant that binds ganglioside G(M1) but fails to induce toxicity.
The Journal of biological chemistry 2001;276(40):36939-45.
2001: Karla Jean Fullner; Wayne I Lencer; John J Mekalanos
Vibrio cholerae-induced cellular responses of polarized T84 intestinal epithelial cells are dependent on production of cholera toxin and the RTX toxin.
Infection and immunity 2001;69(10):6310-7.
2001: A Tholib Aman; S Fraser; Ethan A Merritt; C Rodigherio; M Kenny; Misol Ahn; Wim G J Hol; Neil A Williams; Wayne I Lencer; Timothy R Hirst
A mutant cholera toxin B subunit that binds GM1- ganglioside but lacks immunomodulatory or toxic activity.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(15):8536-41.
2001: Richard S Blumberg; Y van de Wal; Steven Claypool; Nadia Corazza; Bonny L Dickinson; Edward E S Nieuwenhuis; R Pitman; Gerburg M Spiekermann; Xiaoping Zhu; Sean P Colgan; Wayne I Lencer
The multiple roles of major histocompatibility complex class-I-like molecules in mucosal immune function.
Acta odontologica Scandinavica 2001;59(3):139-44.
2001: Wayne I Lencer
Microbes and microbial Toxins: paradigms for microbial-mucosal toxins. V. Cholera: invasion of the intestinal epithelial barrier by a stably folded protein toxin.
American journal of physiology. Gastrointestinal and liver physiology 2001;280(5):G781-6.
2001: Billy Tsai; Chiara Rodighiero; Wayne I Lencer; Tom A Rapoport
Protein disulfide isomerase acts as a redox-dependent chaperone to unfold cholera toxin.
Cell 2001;104(6):937-48.
2001: Xiaoping Zhu; G Meng; Bonny L Dickinson; X Li; E Mizoguchi; L Miao; Y Wang; C Robert; B Wu; P D Smith; Wayne I Lencer; Richard S Blumberg
MHC class I-related neonatal Fc receptor for IgG is functionally expressed in monocytes, intestinal macrophages, and dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(5):3266-76.
2001: Didier Merlin; Gang Yue; Wayne I Lencer; Michael Selsted; James L Madara
Cryptdin-3 induces novel apical conductance(s) in Cl- secretory, including cystic fibrosis, epithelia.
American journal of physiology. Cell physiology 2001;280(2):C296-302.
2001: Wayne I Lencer
Microbial invasion across the intestinal epithelial barrier.
Pediatric research 2001;49(1):4-5.
2000: S F Mel; Karla Jean Fullner; S Wimer-Mackin; Wayne I Lencer; John J Mekalanos
Association of protease activity in Vibrio cholerae vaccine strains with decreases in transcellular epithelial resistance of polarized T84 intestinal epithelial cells.
Infection and immunity 2000;68(11):6487-92.
2000: Kamran Badizadegan; Anne A Wolf; Chiara Rodighiero; Michael G Jobling; Timothy R Hirst; Randall K Holmes; Wayne I Lencer
Floating cholera toxin into epithelial cells: functional association with caveolae-like detergent-insoluble membrane microdomains.
International journal of medical microbiology : IJMM 2000;290(4-5):403-8.
2000: Kamran Badizadegan; Bonny L Dickinson; Heidi E Wheeler; Richard S Blumberg; Randall K Holmes; Wayne I Lencer
Heterogeneity of detergent-insoluble membranes from human intestine containing caveolin-1 and ganglioside G(M1).
American journal of physiology. Gastrointestinal and liver physiology 2000;278(6):G895-904.
1999: Bonny L Dickinson; Kamran Badizadegan; Zhen Wu; J C Ahouse; Xiaoping Zhu; Neil E Simister; Richard S Blumberg; Wayne I Lencer
Bidirectional FcRn-dependent IgG transport in a polarized human intestinal epithelial cell line.
The Journal of clinical investigation 1999;104(7):903-11.
1999: Wayne I Lencer; Timothy R Hirst; Randall K Holmes
Membrane traffic and the cellular uptake of cholera toxin.
Biochimica et biophysica acta 1999;1450(3):177-90.
1999: Richard S Blumberg; Wayne I Lencer; Xiaoping Zhu; H S Kim; Steven Claypool; Steven P Balk; Lawrence J Saubermann; Sean P Colgan
Antigen presentation by intestinal epithelial cells.
Immunology letters 1999;69(1):7-11.
1999: KE Beauregard; S Wimer-Mackin; R. John Collier; Wayne I Lencer
Anthrax toxin entry into polarized epithelial cells.
Infection and immunity 1999;67(6):3026-30.
1999: Chiara Rodighiero; A Tholib Aman; M J Kenny; J Moss; Wayne I Lencer; Timothy R Hirst
Structural basis for the differential toxicity of cholera toxin and Escherichia coli heat-labile enterotoxin. Construction of hybrid toxins identifies the A2-domain as the determinant of differential toxicity.
The Journal of biological chemistry 1999;274(7):3962-9.
1998: Chiara Rodighiero; A Tholib Aman; Wayne I Lencer; Timothy R Hirst
Differential activity of cholera toxin and E. coli enterotoxin: construction and purification of mutant and hybrid derivatives.
Biochemical Society transactions 1998;26(4):S364.
1998: Didier Merlin; L Jiang; GR Strohmeier; Asma Nusrat; S L Alper; Wayne I Lencer; James L Madara
Distinct Ca2+- and cAMP-dependent anion conductances in the apical membrane of polarized T84 cells.
The American journal of physiology 1998;275(2 Pt 1):C484-95.
1998: Anne A Wolf; Michael G Jobling; S Wimer-Mackin; M Ferguson-Maltzman; James L Madara; Randall K Holmes; Wayne I Lencer
Ganglioside structure dictates signal transduction by cholera toxin and association with caveolae-like membrane domains in polarized epithelia.
The Journal of cell biology 1998;141(4):917-27.
1997: Paul A Rufo; D Merlin; M Riegler; M H Ferguson-Maltzman; Bonny L Dickinson; Carlo Brugnara; Seth L Alper; Wayne I Lencer
The antifungal antibiotic, clotrimazole, inhibits chloride secretion by human intestinal T84 cells via blockade of distinct basolateral K+ conductances. Demonstration of efficacy in intact rabbit colon and in an in vivo mouse model of cholera.
The Journal of clinical investigation 1997;100(12):3111-20.
1997: Wayne I Lencer; G Cheung; GR Strohmeier; M G Currie; Andre J Ouellette; Michael Selsted; James L Madara
Induction of epithelial chloride secretion by channel-forming cryptdins 2 and 3.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(16):8585-9.
1997: Wayne I Lencer; C Constable; S Moe; Paul A Rufo; A Wolf; Michael G Jobling; S P Ruston; James L Madara; Randall K Holmes; Timothy R Hirst
Proteolytic activation of cholera toxin and Escherichia coli labile toxin by entry into host epithelial cells. Signal transduction by a protease-resistant toxin variant.
The Journal of biological chemistry 1997;272(24):15562-8.
1997: GR Strohmeier; Wayne I Lencer; T W Patapoff; L F Thompson; SL Carlson; S J Moe; D K Carnes; Randall J Mrsny; James L Madara
Surface expression, polarization, and functional significance of CD73 in human intestinal epithelia.
The Journal of clinical investigation 1997;99(11):2588-601.
1996: Paul A Rufo; L Jiang; S J Moe; Carlo Brugnara; Seth L Alper; Wayne I Lencer
The antifungal antibiotic, clotrimazole, inhibits Cl- secretion by polarized monolayers of human colonic epithelial cells.
The Journal of clinical investigation 1996;98(9):2066-75.
1996: Jerrold R Turner; Wayne I Lencer; S Carlson; James L Madara
Carboxy-terminal vesicular stomatitis virus G protein-tagged intestinal Na+-dependent glucose cotransporter (SGLT1): maintenance of surface expression and global transport function with selective perturbation of transport kinetics and polarized expression.
The Journal of biological chemistry 1996;271(13):7738-44.
1995: Wayne I Lencer; C Constable; S Moe; Michael G Jobling; H M Webb; S Ruston; James L Madara; Timothy R Hirst; Randall K Holmes
Targeting of cholera toxin and Escherichia coli heat labile toxin in polarized epithelia: role of COOH-terminal KDEL.
The Journal of cell biology 1995;131(4):951-62.
1995: Wayne I Lencer; S Moe; Paul A Rufo; James L Madara
Transcytosis of cholera toxin subunits across model human intestinal epithelia.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(22):10094-8.
1995: Wayne I Lencer; GR Strohmeier; S Moe; S L Carlson; C T Constable; James L Madara
Signal transduction by cholera toxin: processing in vesicular compartments does not require acidification.
The American journal of physiology 1995;269(4 Pt 1):G548-57.
1995: GR Strohmeier; S M Reppert; Wayne I Lencer; James L Madara
The A2b adenosine receptor mediates cAMP responses to adenosine receptor agonists in human intestinal epithelia.
The Journal of biological chemistry 1995;270(5):2387-94.
1994: Timothy R Hirst; Toufic O Nashar; S Eaglestone; Wayne I Lencer; H M Webb; J Yu
Bacterial and host interactions during the biogenesis, toxicity and immunogenicity of Escherichia coli heat-labile enterotoxin.
Biochemical Society transactions 1994;22(2):306-9.
1994: A Dosanjh; Wayne I Lencer; D Brown; Dennis A Ausiello; J L Stow
Heterologous expression of delta F508 CFTR results in decreased sialylation of membrane glycoconjugates.
The American journal of physiology 1994;266(2 Pt 1):C360-6.
1993: Wayne I Lencer; J B de Almeida; S Moe; J L Stow; Dennis A Ausiello; James L Madara
Entry of cholera toxin into polarized human intestinal epithelial cells. Identification of an early brefeldin A sensitive event required for A1-peptide generation.
The Journal of clinical investigation 1993;92(6):2941-51.
1993: F M Apter; Wayne I Lencer; R A Finkelstein; John J Mekalanos; Marian R Neutra
Monoclonal immunoglobulin A antibodies directed against cholera toxin prevent the toxin-induced chloride secretory response and block toxin binding to intestinal epithelial cells in vitro.
Infection and immunity 1993;61(12):5271-8.
1992: James L Madara; Charles A Parkos; Sean P Colgan; R J MacLeod; S Nash; J Matthews; C Delp; Wayne I Lencer
Cl- secretion in a model intestinal epithelium induced by a neutrophil-derived secretagogue.
The Journal of clinical investigation 1992;89(6):1938-44.
1992: Wayne I Lencer; C Delp; Marian R Neutra; James L Madara
Mechanism of cholera toxin action on a polarized human intestinal epithelial cell line: role of vesicular traffic.
The Journal of cell biology 1992;117(6):1197-1209.
1990: Wayne I Lencer; F D Reinhart; Marian R Neutra
Interaction of cholera toxin with cloned human goblet cells in monolayer culture.
The American journal of physiology 1990;258(1 Pt 1):G96-102.
1987: Wayne I Lencer; S H Chu; W A Walker
Differential binding kinetics of cholera toxin to intestinal microvillus membrane during development.
Infection and immunity 1987;55(12):3126-30.