Username

Password

Forgot Password?

Preview

Sign-in free and Explore the Exciting World of BiomedExperts:

Over 1.500.000 Profiles
More than 1.800 Organizations worldwide
State of the Art Network Visualizations

Manage your own Profile
Locate Experts in your Country/Region
Locate Experts in your 1. and 2. Level Network
Connect to Experts Worldwide

NetworkView

Marc Leng

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Concepts & Ideas

Phenomena

Circular Dichroism

Physiology

Genetic Transcription

Sign-in to see full Profile

Network (preview)

Co-Publications
Name
9
boudvillain, marc
7
Malinge, Jean-Marc
6
LOCKER, Daniel
3
Natile, Giovanni
3
Ptak, M
3
Malfoy, Bernard
3
Vogt, Nicolas
3
Vovelle, Françoise
3
Boccarelli, Angelina
3
Coluccia, Mauro
3
Decoville, Martine
3
Giraud-Panis, Marie-Josèphe
3
Guérin, M
3
Intini, Francesco
2
Lancelot, Gérard

Sign-in to see all Coauthors

Publications

TOP 3
Montero Eva I; Pérez José M; Schwartz Annie; Fuertes Miguel A; Malinge Jean M; Alonso Carlos; Leng Marc; Navarro-Ranninger Carmen
Apoptosis induction and DNA interstrand cross-link formation by cytotoxic trans-[PtCl2(NH(CH3)2)(NHCH(CH3)2) : cross-linking between d(G) and complementary d(C) within oligonucleotide duplexes.
Decoville M; Giacomello E; Leng M; Locker D
DSP1, an HMG-like protein, is involved in the regulation of homeotic genes.
Toulmé F; Mosrin-Huaman C; Sparkowski J; Das A; Leng M; Rahmouni A R
GreA and GreB proteins revive backtracked RNA polymerase in vivo by promoting transcript trimming.

Sign-in to see all Publications

Sign in free and see...

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the visualized research activity
of experts around the globe

Sign-in to see more

Geonetwork of Marc Leng (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

Sign-in to see more

All Publications

2002: Montero Eva I; Pérez José M; Schwartz Annie; Fuertes Miguel A; Malinge Jean M; Alonso Carlos; Leng Marc; Navarro-Ranninger Carmen
Apoptosis induction and DNA interstrand cross-link formation by cytotoxic trans-[PtCl2(NH(CH3)2)(NHCH(CH3)2) : cross-linking between d(G) and complementary d(C) within oligonucleotide duplexes.
Chembiochem : a European journal of chemical biology 2002;3(1):61-7.
2001: Decoville M; Giacomello E; Leng M; Locker D
DSP1, an HMG-like protein, is involved in the regulation of homeotic genes.
Genetics 2001;157(1):237-44.
2000: Toulmé F; Mosrin-Huaman C; Sparkowski J; Das A; Leng M; Rahmouni A R
GreA and GreB proteins revive backtracked RNA polymerase in vivo by promoting transcript trimming.
The EMBO journal 2000;19(24):6853-9.
2000: Leng M; Locker D; Giraud-Panis M J; Schwartz A; Intini F P; Natile G; Pisano C; Boccarelli A; Giordano D; Coluccia M
Replacement of an NH(3) by an iminoether in transplatin makes an antitumor drug from an inactive compound.
Molecular pharmacology 2000;58(6):1525-35.
2000: Müller J; Drumm M; Boudvillain M; Leng M; Sletten E; Lippert B
Parallel-stranded DNA with Hoogsteen base pairing stabilized by a trans-[Pt(NH3)2]2+ cross-link: characterization and conversion into a homodimer and a triplex.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2000;5(5):603-11.
2000: Decoville M; Giraud-Panis M J; Mosrin-Huaman C; Leng M; Locker D
HMG boxes of DSP1 protein interact with the rel homology domain of transcription factors.
Nucleic acids research 2000;28(2):454-62.
1999: Paquet F; Boudvillain M; Lancelot G; Leng M
NMR solution structure of a DNA dodecamer containing a transplatin interstrand GN7-CN3 cross-link.
Nucleic acids research 1999;27(21):4261-8.
1999: Coluccia M; Nassi A; Boccarelli A; Giordano D; Cardellicchio N; Locker D; Leng M; Sivo M; Intini F P; Natile G
In vitro and in vivo antitumour activity and cellular pharmacological properties of new platinum-iminoether complexes with different configuration at the iminoether ligands.
Journal of inorganic biochemistry 1999;77(1-2):31-5.
1999: Malinge J M; Giraud-Panis M J; Leng M
Interstrand cross-links of cisplatin induce striking distortions in DNA.
Journal of inorganic biochemistry 1999;77(1-2):23-9.
1999: Toulmé F; Guérin M; Robichon N; Leng M; Rahmouni A R
In vivo evidence for back and forth oscillations of the transcription elongation complex.
The EMBO journal 1999;18(18):5052-60.
1999: Boccarelli A; Coluccia M; Intini F P; Natile G; Locker D; Leng M
Cytotoxicity and DNA binding mode of new platinum-iminoether derivatives with different configuration at the iminoether ligands.
Anti-cancer drug design 1999;14(3):253-64.
1999: Coste F; Malinge J M; Serre L; Shepard W; Roth M; Leng M; Zelwer C
Crystal structure of a double-stranded DNA containing a cisplatin interstrand cross-link at 1.63 A resolution: hydration at the platinated site.
Nucleic acids research 1999;27(8):1837-46.
1998: Gee J E; Robbins I; van der Laan A C; van Boom J H; Colombier C; Leng M; Raible A M; Nelson J S; Lebleu B
Assessment of high-affinity hybridization, RNase H cleavage, and covalent linkage in translation arrest by antisense oligonucleotides.
Antisense & nucleic acid drug development 1998;8(2):103-11.
1998: Figueroa-Bossi N; Guérin M; Rahmouni R; Leng M; Bossi L
The supercoiling sensitivity of a bacterial tRNA promoter parallels its responsiveness to stringent control.
The EMBO journal 1998;17(8):2359-67.
1997: Colombier C; Boudvillain M; Leng M
Interstrand crosslinking reaction in transplatin-modified oligo-2'-O-methyl ribonucleotide-RNA hybrids.
Antisense & nucleic acid drug development 1997;7(4):397-402.
1997: Bernal-Méndez E; Boudvillain M; González-Vilchez F; Leng M
Chemical versatility of transplatin monofunctional adducts within multiple site-specifically platinated DNA.
Biochemistry 1997;36(24):7281-7.
1997: Prévost C; Boudvillain M; Beudaert P; Leng M; Lavery R; Vovelle F
Distortions of the DNA double helix induced by 1,3-trans-diamminedichloroplatinum(II)-intrastrand cross-link: an internal coordinate molecular modeling study.
Journal of biomolecular structure & dynamics 1997;14(6):703-14.
1997: Boudvillain M; Guérin M; Dalbiès R; Saison-Behmoaras T; Leng M
Transplatin-modified oligo(2'-O-methyl ribonucleotide)s: a new tool for selective modulation of gene expression.
Biochemistry 1997;36(10):2925-31.
1997: Pérez C; Leng M; Malinge J M
Rearrangement of interstrand cross-links into intrastrand cross-links in cis-diamminedichloroplatinum(II)-modified DNA.
Nucleic acids research 1997;25(4):896-903.
1997: Canaple L; Decoville M; Leng M; Locker D
The Drosophila DSP1 gene encoding an HMG 1-like protein: genomic organization, evolutionary conservation and expression.
Gene 1997;184(2):285-90.
1996: Colombier C; Lippert B; Leng M
Interstrand cross-linking reaction in triplexes containing a monofunctional transplatin-adduct.
Nucleic acids research 1996;24(22):4519-24.
1996: Guérin M; Leng M; Rahmouni A R
High resolution mapping of E.coli transcription elongation complex in situ reveals protein interactions with the non-transcribed strand.
The EMBO journal 1996;15(19):5397-407.
1996: Paquet F; Pérez C; Leng M; Lancelot G; Malinge J M
NMR solution structure of a DNA decamer containing an interstrand cross-link of the antitumor drug cis-diamminedichloroplatinum (II).
Journal of biomolecular structure & dynamics 1996;14(1):67-77.
1996: Boudvillain M; Dalbiès R; Leng M
Evidences for a catalytic activity of the DNA double helix in the reaction between DNA, platinum(II), and intercalators.
Metal ions in biological systems 1996;33():87-104.
1995: Albert A C; Leng M; Rahmouni A R
The size of the topological domain modulates the B-Z transition of a (TG)n containing repeat.
Journal of biomolecular structure & dynamics 1995;13(1):47-56.
1995: Boudvillain M; Dalbiès R; Aussourd C; Leng M
Intrastrand cross-links are not formed in the reaction between transplatin and native DNA: relation with the clinical inefficiency of transplatin.
Nucleic acids research 1995;23(13):2381-8.
1995: Dalbiès R; Boudvillain M; Leng M
Linkage isomerization reaction of intrastrand cross-links in trans-diamminedichloroplatinum(II)-modified single-stranded oligonucleotides.
Nucleic acids research 1995;23(6):949-53.
1994: Malinge J M; Pérez C; Leng M
Base sequence-independent distorsions induced by interstrand cross-links in cis-diamminedichloroplatinum (II)-modified DNA.
Nucleic acids research 1994;22(19):3834-9.
1994: Albert A C; Roman A M; Bouche G; Leng M; Rahmouni A R
Gradual and oriented B-Z transition in 5'-untranscribed region of mouse ribosomal DNA.
The Journal of biological chemistry 1994;269(30):19238-44.
1994: Schwartz A; Leng M
DNase I footprinting of cis- or trans-diamminedichloroplatinum(II)-modified DNA.
Journal of molecular biology 1994;236(4):969-74.
1993: Payet D; Gaucheron F; Sip M; Leng M
Instability of the monofunctional adducts in cis-[Pt(NH3)2(N7-N-methyl-2-diazapyrenium)Cl](2+)-modified DNA: rates of cross-linking reactions in cis-platinum-modified DNA.
Nucleic acids research 1993;21(25):5846-51.
1993: Brabec V; Síp M; Leng M
DNA conformational change produced by the site-specific interstrand cross-link of trans-diamminedichloroplatinum(II).
Biochemistry 1993;32(43):11676-81.
1992: Brabec V; Reedijk J; Leng M
Sequence-dependent distortions induced in DNA by monofunctional platinum(II) binding.
Biochemistry 1992;31(49):12397-402.
1992: Anin M F; Gaucheron F; Leng M
Lability of monofunctional cis-platinum adducts: role of DNA double helix.
Nucleic acids research 1992;20(18):4825-30.
1992: Sip M; Schwartz A; Vovelle F; Ptak M; Leng M
Distortions induced in DNA by cis-platinum interstrand adducts.
Biochemistry 1992;31(9):2508-13.
1991: Gaucheron F; Malinge J M; Blacker A J; Lehn J M; Leng M
Possible catalytic activity of DNA in the reaction between the antitumor drug cis-diamminedichloroplatinum(II) and the intercalator N-methyl-2,7-diazapyrenium.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(9):3516-9.
1991: Lemaire M A; Schwartz A; Rahmouni A R; Leng M
Interstrand cross-links are preferentially formed at the d(GC) sites in the reaction between cis-diamminedichloroplatinum (II) and DNA.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(5):1982-5.
1990: Anin M F; Leng M
Distortions induced in double-stranded oligonucleotides by the binding of cis- or trans-diammine-dichloroplatinum(II) to the d(GTG) sequence.
Nucleic acids research 1990;18(15):4395-400.
1990: Malinge J M; Sip M; Blacker A J; Lehn J M; Leng M
Formation of a DNA monofunctional cis-platinum adduct cross-linking the intercalating drug N-methyl-2,7-diazapyrenium.
Nucleic acids research 1990;18(13):3887-91.
1989: Mazeau K; Vovelle F; Rahmouni A; Leng M; Ptak M
Structure of the intrastrand cis-[Pt(NH3)2(d(GpCpG))] adduct in a dodecanucleotide duplex: II. A molecular mechanics modeling study.
Anti-cancer drug design 1989;4(1):63-78.
1989: Ptak M; Rahmouni A; Mazeau K; Thuong N T; Leng M
Structure of the intrastrand cis-[Pt(NH3)2(d(GpCpG))] adduct in a dodecanucleotide duplex: I. A 1H and 31P n.m.r. study.
Anti-cancer drug design 1989;4(1):53-61.
1989: Schwartz A; Marrot L; Leng M
The DNA bending by acetylaminofluorene residues and by apurinic sites.
Journal of molecular biology 1989;207(2):445-50.
1989: Marrot L; Leng M
Chemical probes of the conformation of DNA modified by cis-diamminedichloroplatinum(II).
Biochemistry 1989;28(4):1454-61.
1988: Vogt N; Rousseau N; Leng M; Malfoy B
A study of the B-Z transition of the AC-rich region of the repeat unit of a satellite DNA from Cebus by means of chemical probes.
The Journal of biological chemistry 1988;263(24):11826-32.
1988: Malinge J M; Leng M
Reactivity of monofunctional cis-platinum adducts as a function of DNA sequence.
Nucleic acids research 1988;16(15):7663-72.
1988: Vogt N; Marrot L; Rousseau N; Malfoy B; Leng M
Chloroacetaldehyde reacts with Z-DNA.
Journal of molecular biology 1988;201(4):773-6.
1988: Hebert E; Diancourt F; Saint-Ruf G; Leng M
Mutation spectrum of the mutagen 3-N,N-acetoxyacetylamino-4,6-dimethyldipyrido[1,2-a:3',2'- d]imidazole in Escherichia coli.
Carcinogenesis 1988;9(1):183-5.
1987: Marrot L; Hebert E; Saint-Ruf G; Leng M
Comparison of the reactivity of B-DNA and Z-DNA with two isosteric chemical carcinogens: 2-N,N-acetoxyacetylaminofluorene and 3-N,N-acetoxyacetylamino-4,6-dimethyldipyrido-[1,2-a:3',2' -d] imidazole.
Nucleic acids research 1987;15(14):5629-42.
1986: Pfohl-Leszkowicz A; Hebert E; Saint-Ruf G; Leng M; Dirheimer G
In vitro enzymatic methylation of DNA modified with the mutagenic amine: 3-N,N-acetoxyacetylamino-4,6-dimethyldipyrido(1,2-a:3'2'-d )imidazole.
Cancer letters 1986;32(1):65-71.
1986: Malfoy B; Rousseau N; Vogt N; Viegas-Pequignot E; Dutrillaux B; Leng M
Nucleotide sequence of an heterochromatic segment recognized by the antibodies to Z-DNA in fixed metaphase chromosomes.
Nucleic acids research 1986;14(8):3197-214.
1985: Hebert E; Saint-Ruf G; Leng M
Immunological titration of 3-N-acetyl-hydroxyamino-4,6-dimethyldipyrido(1,2-a:3',2'-d) imidazole-rat liver DNA adducts.
Carcinogenesis 1985;6(6):937-9.
1985: Loukakou B; Hebert E; Saint-Ruf G; Leng M
Reaction of DNA with a mutagenic 3-N,N-acetoxyacetylamino-4,6-dimethyldipyrido[1,2-a:3',2'- d]imidazole (N-AcO-AGlu-P-3) related to glutamic acid pyrolysates.
Carcinogenesis 1985;6(3):377-83.
1984: Hébert E; Loukakou B; Saint-Ruf G; Leng M
Conformational changes induced in DNA by the in vitro reaction with the mutagenic amine: 3-N,N-acetoxyacetylamino-4,6-dimethyldipyrido (1,2-a: 3', 2'-d) imidazole.
Nucleic acids research 1984;12(22):8553-66.
1982: Malfoy B; Rousseau N; Leng M
Interaction between antibodies to Z-form deoxyribonucleic acid and double-stranded polynucleotides.
Biochemistry 1982;21(22):5463-7.
1980: Spodheim-Maurizot M; Saint-Ruf G; Leng M
Antibodies to N-hydroxy-2-aminofluorene modified DNA as probes in the study of DNA reacted with derivatives of 2-acetylaminofluorene.
Carcinogenesis 1980;1(10):807-12.

Sign-in to see more