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Marc Leng

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Chemicals & Drugs

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Publications

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Eva Montero; José M Pérez; Annie Schwartz; Miguel A Fuertes; Jean M Malinge; Carlos Alonso; Marc Leng; Carmen Navarro-Ranninger
Apoptosis induction and DNA interstrand cross-link formation by cytotoxic trans-[PtCl2(NH(CH3)2)(NHCH(CH3)2) : cross-linking between d(G) and complementary d(C) within oligonucleotide duplexes.
Martine Decoville; E Giacomello; Marc Leng; Daniel LOCKER
DSP1, an HMG-like protein, is involved in the regulation of homeotic genes.
Francine Toulmé; Christine Mosrin-Huaman; J Sparkowski; Asis K Das; Marc Leng; A Rachid Rahmouni
GreA and GreB proteins revive backtracked RNA polymerase in vivo by promoting transcript trimming.

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All Publications

2002: Eva Montero; José M Pérez; Annie Schwartz; Miguel A Fuertes; Jean M Malinge; Carlos Alonso; Marc Leng; Carmen Navarro-Ranninger
Apoptosis induction and DNA interstrand cross-link formation by cytotoxic trans-[PtCl2(NH(CH3)2)(NHCH(CH3)2) : cross-linking between d(G) and complementary d(C) within oligonucleotide duplexes.
Chembiochem : a European journal of chemical biology 2002;3(1):61-7.
2001: Martine Decoville; E Giacomello; Marc Leng; Daniel LOCKER
DSP1, an HMG-like protein, is involved in the regulation of homeotic genes.
Genetics 2001;157(1):237-44.
2000: Francine Toulmé; Christine Mosrin-Huaman; J Sparkowski; Asis K Das; Marc Leng; A Rachid Rahmouni
GreA and GreB proteins revive backtracked RNA polymerase in vivo by promoting transcript trimming.
The EMBO journal 2000;19(24):6853-9.
2000: Marc Leng; Daniel LOCKER; Marie-Josèphe Giraud-Panis; A Schwartz; Francesco P Intini; Giovanni Natile; C Pisano; Angelina Boccarelli; Domenico Giordano; Mauro Coluccia
Replacement of an NH(3) by an iminoether in transplatin makes an antitumor drug from an inactive compound.
Molecular pharmacology 2000;58(6):1525-35.
2000: Jens Müller; M Drumm; marc boudvillain; Marc Leng; E Sletten; Bernhard Lippert
Parallel-stranded DNA with Hoogsteen base pairing stabilized by a trans-[Pt(NH3)2]2+ cross-link: characterization and conversion into a homodimer and a triplex.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2000;5(5):603-11.
2000: Martine Decoville; Marie-Josèphe Giraud-Panis; Christine Mosrin-Huaman; Marc Leng; Daniel LOCKER
HMG boxes of DSP1 protein interact with the rel homology domain of transcription factors.
Nucleic acids research 2000;28(2):454-62.
1999: Françoise Paquet; marc boudvillain; Gérard Lancelot; Marc Leng
NMR solution structure of a DNA dodecamer containing a transplatin interstrand GN7-CN3 cross-link.
Nucleic acids research 1999;27(21):4261-8.
1999: Mauro Coluccia; A Nassi; Angelina Boccarelli; Domenico Giordano; N Cardellicchio; Daniel LOCKER; Marc Leng; Maria F Sivo; Francesco P Intini; Giovanni Natile
In vitro and in vivo antitumour activity and cellular pharmacological properties of new platinum-iminoether complexes with different configuration at the iminoether ligands.
Journal of inorganic biochemistry 1999;77(1-2):31-5.
1999: Jean-Marc Malinge; Marie-Josèphe Giraud-Panis; Marc Leng
Interstrand cross-links of cisplatin induce striking distortions in DNA.
Journal of inorganic biochemistry 1999;77(1-2):23-9.
1999: Francine Toulmé; M Guérin; N Robichon; Marc Leng; A Rachid Rahmouni
In vivo evidence for back and forth oscillations of the transcription elongation complex.
The EMBO journal 1999;18(18):5052-60.
1999: Angelina Boccarelli; Mauro Coluccia; Francesco P Intini; Giovanni Natile; Daniel LOCKER; Marc Leng
Cytotoxicity and DNA binding mode of new platinum-iminoether derivatives with different configuration at the iminoether ligands.
Anti-cancer drug design 1999;14(3):253-64.
1999: Franck Coste; Jean-Marc Malinge; Laurence Serre; W Shepard; M Roth; Marc Leng; Charles Zelwer
Crystal structure of a double-stranded DNA containing a cisplatin interstrand cross-link at 1.63 A resolution: hydration at the platinated site.
Nucleic acids research 1999;27(8):1837-46.
1998: Nara Figueroa-Bossi; M Guérin; R Rahmouni; Marc Leng; Lionello Bossi
The supercoiling sensitivity of a bacterial tRNA promoter parallels its responsiveness to stringent control.
The EMBO journal 1998;17(8):2359-67.
1998: J E Gee; Ian Robbins; A C van der Laan; J H van Boom; C Colombier; Marc Leng; A M Raible; J S Nelson; Bernard Lebleu
Assessment of high-affinity hybridization, RNase H cleavage, and covalent linkage in translation arrest by antisense oligonucleotides.
Antisense & nucleic acid drug development 1998;8(2):103-11.
1997: C Colombier; marc boudvillain; Marc Leng
Interstrand crosslinking reaction in transplatin-modified oligo-2'-O-methyl ribonucleotide-RNA hybrids.
Antisense & nucleic acid drug development 1997;7(4):397-402.
1997: E Bernal-Méndez; marc boudvillain; F González-Vilchez; Marc Leng
Chemical versatility of transplatin monofunctional adducts within multiple site-specifically platinated DNA.
Biochemistry 1997;36(24):7281-7.
1997: Chantal Prévost; marc boudvillain; P Beudaert; Marc Leng; Richard Lavery; Françoise Vovelle
Distortions of the DNA double helix induced by 1,3-trans-diamminedichloroplatinum(II)-intrastrand cross-link: an internal coordinate molecular modeling study.
Journal of biomolecular structure & dynamics 1997;14(6):703-14.
1997: marc boudvillain; M Guérin; R Dalbiès; T Saison-Behmoaras; Marc Leng
Transplatin-modified oligo(2'-O-methyl ribonucleotide)s: a new tool for selective modulation of gene expression.
Biochemistry 1997;36(10):2925-31.
1997: C Pérez; Marc Leng; Jean-Marc Malinge
Rearrangement of interstrand cross-links into intrastrand cross-links in cis-diamminedichloroplatinum(II)-modified DNA.
Nucleic acids research 1997;25(4):896-903.
1997: L Canaple; Martine Decoville; Marc Leng; Daniel LOCKER
The Drosophila DSP1 gene encoding an HMG 1-like protein: genomic organization, evolutionary conservation and expression.
Gene 1997;184(2):285-90.
1996: C Colombier; B Lippert; Marc Leng
Interstrand cross-linking reaction in triplexes containing a monofunctional transplatin-adduct.
Nucleic acids research 1996;24(22):4519-24.
1996: M Guérin; Marc Leng; A R Rahmouni
High resolution mapping of E.coli transcription elongation complex in situ reveals protein interactions with the non-transcribed strand.
The EMBO journal 1996;15(19):5397-407.
1996: F Paquet; C Pérez; Marc Leng; Gérard Lancelot; J M Malinge
NMR solution structure of a DNA decamer containing an interstrand cross-link of the antitumor drug cis-diamminedichloroplatinum (II).
Journal of biomolecular structure & dynamics 1996;14(1):67-77.
1996: marc boudvillain; R Dalbiès; Marc Leng
Evidences for a catalytic activity of the DNA double helix in the reaction between DNA, platinum(II), and intercalators.
Metal ions in biological systems 1996;33():87-104.
1995: A C Albert; Marc Leng; A R Rahmouni
The size of the topological domain modulates the B-Z transition of a (TG)n containing repeat.
Journal of biomolecular structure & dynamics 1995;13(1):47-56.
1995: marc boudvillain; R Dalbiès; C Aussourd; Marc Leng
Intrastrand cross-links are not formed in the reaction between transplatin and native DNA: relation with the clinical inefficiency of transplatin.
Nucleic acids research 1995;23(13):2381-8.
1995: R Dalbiès; marc boudvillain; Marc Leng
Linkage isomerization reaction of intrastrand cross-links in trans-diamminedichloroplatinum(II)-modified single-stranded oligonucleotides.
Nucleic acids research 1995;23(6):949-53.
1994: Jean-Marc Malinge; C Pérez; Marc Leng
Base sequence-independent distorsions induced by interstrand cross-links in cis-diamminedichloroplatinum (II)-modified DNA.
Nucleic acids research 1994;22(19):3834-9.
1994: A C Albert; A M Roman; G Bouche; Marc Leng; A R Rahmouni
Gradual and oriented B-Z transition in 5'-untranscribed region of mouse ribosomal DNA.
The Journal of biological chemistry 1994;269(30):19238-44.
1994: A Schwartz; Marc Leng
DNase I footprinting of cis- or trans-diamminedichloroplatinum(II)-modified DNA.
Journal of molecular biology 1994;236(4):969-74.
1993: D Payet; F Gaucheron; M Sip; Marc Leng
Instability of the monofunctional adducts in cis-[Pt(NH3)2(N7-N-methyl-2-diazapyrenium)Cl](2+)-modified DNA: rates of cross-linking reactions in cis-platinum-modified DNA.
Nucleic acids research 1993;21(25):5846-51.
1993: V Brabec; M Síp; Marc Leng
DNA conformational change produced by the site-specific interstrand cross-link of trans-diamminedichloroplatinum(II).
Biochemistry 1993;32(43):11676-81.
1992: V Brabec; Jan Reedijk; Marc Leng
Sequence-dependent distortions induced in DNA by monofunctional platinum(II) binding.
Biochemistry 1992;31(49):12397-402.
1992: M F Anin; F Gaucheron; Marc Leng
Lability of monofunctional cis-platinum adducts: role of DNA double helix.
Nucleic acids research 1992;20(18):4825-30.
1992: M Sip; A Schwartz; Françoise Vovelle; M Ptak; Marc Leng
Distortions induced in DNA by cis-platinum interstrand adducts.
Biochemistry 1992;31(9):2508-13.
1991: F Gaucheron; Jean-Marc Malinge; A J Blacker; Jean-Marie Lehn; Marc Leng
Possible catalytic activity of DNA in the reaction between the antitumor drug cis-diamminedichloroplatinum(II) and the intercalator N-methyl-2,7-diazapyrenium.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(9):3516-9.
1991: M A Lemaire; A Schwartz; A R Rahmouni; Marc Leng
Interstrand cross-links are preferentially formed at the d(GC) sites in the reaction between cis-diamminedichloroplatinum (II) and DNA.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(5):1982-5.
1990: M F Anin; Marc Leng
Distortions induced in double-stranded oligonucleotides by the binding of cis- or trans-diammine-dichloroplatinum(II) to the d(GTG) sequence.
Nucleic acids research 1990;18(15):4395-400.
1990: Jean-Marc Malinge; M Sip; A J Blacker; Jean-Marie Lehn; Marc Leng
Formation of a DNA monofunctional cis-platinum adduct cross-linking the intercalating drug N-methyl-2,7-diazapyrenium.
Nucleic acids research 1990;18(13):3887-91.
1989: K Mazeau; Françoise Vovelle; A Rahmouni; Marc Leng; M Ptak
Structure of the intrastrand cis-[Pt(NH3)2(d(GpCpG))] adduct in a dodecanucleotide duplex: II. A molecular mechanics modeling study.
Anti-cancer drug design 1989;4(1):63-78.
1989: M Ptak; A Rahmouni; K Mazeau; N T Thuong; Marc Leng
Structure of the intrastrand cis-[Pt(NH3)2(d(GpCpG))] adduct in a dodecanucleotide duplex: I. A 1H and 31P n.m.r. study.
Anti-cancer drug design 1989;4(1):53-61.
1989: A Schwartz; L Marrot; Marc Leng
The DNA bending by acetylaminofluorene residues and by apurinic sites.
Journal of molecular biology 1989;207(2):445-50.
1989: L Marrot; Marc Leng
Chemical probes of the conformation of DNA modified by cis-diamminedichloroplatinum(II).
Biochemistry 1989;28(4):1454-61.
1988: Nicolas Vogt; N Rousseau; Marc Leng; Bernard Malfoy
A study of the B-Z transition of the AC-rich region of the repeat unit of a satellite DNA from Cebus by means of chemical probes.
The Journal of biological chemistry 1988;263(24):11826-32.
1988: Jean-Marc Malinge; Marc Leng
Reactivity of monofunctional cis-platinum adducts as a function of DNA sequence.
Nucleic acids research 1988;16(15):7663-72.
1988: Nicolas Vogt; L Marrot; N Rousseau; Bernard Malfoy; Marc Leng
Chloroacetaldehyde reacts with Z-DNA.
Journal of molecular biology 1988;201(4):773-6.
1988: E Hebert; F Diancourt; G Saint-Ruf; Marc Leng
Mutation spectrum of the mutagen 3-N,N-acetoxyacetylamino-4,6-dimethyldipyrido[1,2-a:3',2'- d]imidazole in Escherichia coli.
Carcinogenesis 1988;9(1):183-5.
1987: L Marrot; E Hebert; G Saint-Ruf; Marc Leng
Comparison of the reactivity of B-DNA and Z-DNA with two isosteric chemical carcinogens: 2-N,N-acetoxyacetylaminofluorene and 3-N,N-acetoxyacetylamino-4,6-dimethyldipyrido-[1,2-a:3',2' -d] imidazole.
Nucleic acids research 1987;15(14):5629-42.
1986: A Pfohl-Leszkowicz; E Hebert; G Saint-Ruf; Marc Leng; G Dirheimer
In vitro enzymatic methylation of DNA modified with the mutagenic amine: 3-N,N-acetoxyacetylamino-4,6-dimethyldipyrido(1,2-a:3'2'-d )imidazole.
Cancer letters 1986;32(1):65-71.
1986: Bernard Malfoy; N Rousseau; Nicolas Vogt; E Viegas-Pequignot; Bernard Dutrillaux; Marc Leng
Nucleotide sequence of an heterochromatic segment recognized by the antibodies to Z-DNA in fixed metaphase chromosomes.
Nucleic acids research 1986;14(8):3197-214.
1985: E Hebert; G Saint-Ruf; Marc Leng
Immunological titration of 3-N-acetyl-hydroxyamino-4,6-dimethyldipyrido(1,2-a:3',2'-d) imidazole-rat liver DNA adducts.
Carcinogenesis 1985;6(6):937-9.
1985: B Loukakou; E Hebert; G Saint-Ruf; Marc Leng
Reaction of DNA with a mutagenic 3-N,N-acetoxyacetylamino-4,6-dimethyldipyrido[1,2-a:3',2'- d]imidazole (N-AcO-AGlu-P-3) related to glutamic acid pyrolysates.
Carcinogenesis 1985;6(3):377-83.
1984: E Hébert; B Loukakou; G Saint-Ruf; Marc Leng
Conformational changes induced in DNA by the in vitro reaction with the mutagenic amine: 3-N,N-acetoxyacetylamino-4,6-dimethyldipyrido (1,2-a: 3', 2'-d) imidazole.
Nucleic acids research 1984;12(22):8553-66.
1982: B Malfoy; N Rousseau; Marc Leng
Interaction between antibodies to Z-form deoxyribonucleic acid and double-stranded polynucleotides.
Biochemistry 1982;21(22):5463-7.
1980: M Spodheim-Maurizot; G Saint-Ruf; Marc Leng
Antibodies to N-hydroxy-2-aminofluorene modified DNA as probes in the study of DNA reacted with derivatives of 2-acetylaminofluorene.
Carcinogenesis 1980;1(10):807-12.