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Qiang Leng

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Aaron M Ring; Qiang Leng; Jesse Rinehart; Frederick H Wilson; Kristopher T Kahle; Steven C Hebert; Richard P Lifton
An SGK1 site in WNK4 regulates Na+ channel and K+ channel activity and has implications for aldosterone signaling and K+ homeostasis.
Aaron M Ring; Sam X Cheng; Qiang Leng; Kristopher T Kahle; Jesse Rinehart; Maria D Lalioti; Heather M Volkman; Frederick H Wilson; Steven C Hebert; Richard P Lifton
WNK4 regulates activity of the epithelial Na+ channel in vitro and in vivo.
Matthew A Bailey; A Cantone; Qingshang Yan; Gordon G MacGregor; Qiang Leng; J B O Amorim; Tong Wang; Steven C Hebert; Gerhard Giebisch; Gerhard Malnic
Maxi-K channels contribute to urinary potassium excretion in the ROMK-deficient mouse model of Type II Bartter's syndrome and in adaptation to a high-K diet.

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2007: Aaron M Ring; Qiang Leng; Jesse Rinehart; Frederick H Wilson; Kristopher T Kahle; Steven C Hebert; Richard P Lifton
An SGK1 site in WNK4 regulates Na+ channel and K+ channel activity and has implications for aldosterone signaling and K+ homeostasis.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(10):4025-9.
2007: Aaron M Ring; Sam X Cheng; Qiang Leng; Kristopher T Kahle; Jesse Rinehart; Maria D Lalioti; Heather M Volkman; Frederick H Wilson; Steven C Hebert; Richard P Lifton
WNK4 regulates activity of the epithelial Na+ channel in vitro and in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(10):4020-4.
2006: Matthew A Bailey; A Cantone; Qingshang Yan; Gordon G MacGregor; Qiang Leng; J B O Amorim; Tong Wang; Steven C Hebert; Gerhard Giebisch; Gerhard Malnic
Maxi-K channels contribute to urinary potassium excretion in the ROMK-deficient mouse model of Type II Bartter's syndrome and in adaptation to a high-K diet.
Kidney international 2006;70(1):51-9.
2006: Ming Lu; Qiang Leng; Marie E Egan; Michael J Caplan; Emile L Boulpaep; Gerhard Giebisch; Steven C Hebert
CFTR is required for PKA-regulated ATP sensitivity of Kir1.1 potassium channels in mouse kidney.
The Journal of clinical investigation 2006;116(3):797-807.
2006: Qiang Leng; Kristopher T Kahle; Jesse Rinehart; Gordon G MacGregor; Frederick H Wilson; Cecilia M Canessa; Richard P Lifton; Steven C Hebert
WNK3, a kinase related to genes mutated in hereditary hypertension with hyperkalaemia, regulates the K+ channel ROMK1 (Kir1.1).
The Journal of physiology 2006;571(Pt 2):275-86.
2006: Qiang Leng; Gordon G MacGregor; Ke Dong; Gerhard Giebisch; Steven C Hebert
Subunit-subunit interactions are critical for proton sensitivity of ROMK: evidence in support of an intermolecular gating mechanism.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(6):1982-7.
2005: Anthony D O'Connell; Qiang Leng; Ke Dong; Gordon G MacGregor; Gerhard Giebisch; Steven C Hebert
Phosphorylation-regulated endoplasmic reticulum retention signal in the renal outer-medullary K+ channel (ROMK).
Proceedings of the National Academy of Sciences of the United States of America 2005;102(28):9954-9.
2005: Ke Dong; Lie-Qi Tang; Gordon G MacGregor; Qiang Leng; Steven C Hebert
Novel nucleotide-binding sites in ATP-sensitive potassium channels formed at gating interfaces.
The EMBO journal 2005;24(7):1318-29.
2003: Kristopher T Kahle; Frederick H Wilson; Qiang Leng; Maria D Lalioti; Anthony D O'Connell; Ke Dong; Alicia K Rapson; Gordon G MacGregor; Gerhard Giebisch; Steven C Hebert; Richard P Lifton
WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion.
Nature genetics 2003;35(4):372-6.