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Sean Leng

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Damani A Piggott; Todd T Brown; Sean X Leng; Shruti Hemendra Mehta; Abimereki D Muzaale; Kushang V Patel; Gregory D Kirk
Frailty, HIV infection, and mortality in an aging cohort of injection drug users.
Huifen Li; Bhavish Manwani; Sean X Leng
Frailty, inflammation, and immunity.
Sean X Leng
Role of chronic cytomegalovirus infection in T-cell immunosenescence and frailty: more questions than answers.

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All Publications

2013: Damani A Piggott; Todd T Brown; Sean X Leng; Shruti Hemendra Mehta; Abimereki D Muzaale; Kushang V Patel; Gregory D Kirk
Frailty, HIV infection, and mortality in an aging cohort of injection drug users.
PloS one 2013;8(1):e54910.
2011: Huifen Li; Bhavish Manwani; Sean X Leng
Frailty, inflammation, and immunity.
Aging and disease 2011;2(6):466-73.
2011: Sean X Leng
Role of chronic cytomegalovirus infection in T-cell immunosenescence and frailty: more questions than answers.
Journal of the American Geriatrics Society 2011;59(12):2363-5.
2011: Sean X Leng; Huifen Li; Bhavish Manwani; Joseph B Margolick; Tricia Nilles; TAO QU; Richard D Semba; Jeremy Walston; Xi Yang; Xu Yao; Luigi Ferrucci; Linda P Fried; Jay H Bream
Relationship between cytomegalovirus (CMV) IgG serology, detectable CMV DNA in peripheral monocytes, and CMV pp65(495-503)-specific CD8+ T cells in older adults.
Age (Dordrecht, Netherlands) 2011;33(4):607-14.
2011: Lauren G Koch; Sean X Leng; Nathan R Qi; Natale Rolim; Godfrey L Smith; Elizabeth M van Grevenhof; John Wilkinson; Helene Wisløff; Peter M Abadir; Piter Bijma; steven britton; Charles F Burant; Oyvind Ellingsen; Lori J Gilligan; Morten A Høydal; Ole J Kemi; Ulrik Wisløff
Intrinsic aerobic capacity sets a divide for aging and longevity.
Circulation research 2011;109(10):1162-72.
2011: Sean X Leng; Huifen Li; Neal S Fedarko; Luigi Ferrucci; Linda P Fried; Jing Tian; Qian-Li Xue; Xi Yang; Richard D Semba
Association of detectable cytomegalovirus (CMV) DNA in monocytes rather than positive CMV IgG serology with elevated neopterin levels in community-dwelling older adults.
Experimental gerontology 2011;46(8):679-84.
2011: Xu Yao; SHU-HUI YEH; Jay H Bream; Linda P Fried; Robert G Hamilton; Huifen Li; Barbara Resnick; Jing Tian; Jeremy Walston; Nan-ping Weng; Xiyan Xu; Qian-Li Xue; Sean X Leng
Frailty is associated with impairment of vaccine-induced antibody response and increase in post-vaccination influenza infection in community-dwelling older adults.
Vaccine 2011;29(31):5015-21.
2011: Sean X Leng; Huifen Li; Amy Matteini; XINPING TIAN; Jeremy Walston; Jennifer Hughes; Alka Jain; Neal S Fedarko
IL-6-independent association of elevated serum neopterin levels with prevalent frailty in community-dwelling older adults.
Age and ageing 2011;40(4):475-81.
2011: Xu Yao; Huifen Li; Sean X Leng
Inflammation and immune system alterations in frailty.
Clinics in geriatric medicine 2011;27(1):79-87.
2010: Monique E Spencer; Alka Jain; Amy Matteini; Brock A Beamer; Nae-Yuh Wang; Sean X Leng; Naresh M Punjabi; Jeremy Walston; Neal S Fedarko
Serum levels of the immune activation marker neopterin change with age and gender and are modified by race, BMI, and percentage of body fat.
The journals of gerontology. Series A, Biological sciences and medical sciences 2010;65(8):858-65.
2010: Sean X Leng; XINPING TIAN; Xiaohong Liu; GERALD LAZARUS; Michele F Bellantoni; William B Greenough; Linda P Fried; Ti Shen; Samuel C Durso
An international model for geriatrics program development in China: the Johns Hopkins-Peking Union Medical College experience.
Journal of the American Geriatrics Society 2010;58(7):1376-81.
2009: Linda P Fried; Qian-Li Xue; Anne R Cappola; Luigi Ferrucci; Paulo H M Chaves; Ravi Varadhan; Jack M Guralnik; Sean X Leng; Richard D Semba; Jeremy Walston; Caroline S Blaum; Karen Bandeen-Roche
Nonlinear multisystem physiological dysregulation associated with frailty in older women: implications for etiology and treatment.
The journals of gerontology. Series A, Biological sciences and medical sciences 2009;64(10):1049-57.
2009: Sean X Leng; Qian-Li Xue; Jing Tian; Yi Huang; SHU-HUI YEH; Linda P Fried
Associations of neutrophil and monocyte counts with frailty in community-dwelling disabled older women: results from the Women's Health and Aging Studies I.
Experimental gerontology 2009;44(8):511-6.
2009: TAO QU; Huanle Yang; Jeremy Walston; Neal S Fedarko; Sean X Leng
Upregulated monocytic expression of CXC chemokine ligand 10 (CXCL-10) and its relationship with serum interleukin-6 levels in the syndrome of frailty.
Cytokine 2009;46(3):319-24.
2009: Sean X Leng; Will Hung; Anne R Cappola; QILU YU; Qian-Li Xue; Linda P Fried
White blood cell counts, insulin-like growth factor-1 levels, and frailty in community-dwelling older women.
The journals of gerontology. Series A, Biological sciences and medical sciences 2009;64(4):499-502.
2009: TAO QU; Jeremy Walston; Huanle Yang; Neal S Fedarko; Qian-Li Xue; Brock A Beamer; Luigi Ferrucci; Noel R Rose; Sean X Leng
Upregulated ex vivo expression of stress-responsive inflammatory pathway genes by LPS-challenged CD14(+) monocytes in frail older adults.
Mechanisms of ageing and development 2009;130(3):161-6.
2008: Sean X Leng; Janet E McElhaney; Jeremy Walston; Dongxu Xie; Neal S Fedarko; George A Kuchel
ELISA and multiplex technologies for cytokine measurement in inflammation and aging research.
The journals of gerontology. Series A, Biological sciences and medical sciences 2008;63(8):879-84.
2008: Sara Espinoza; Hongfei Guo; Neal S Fedarko; Amy Elizabeth Dezern; Linda P Fried; Qian-Li Xue; Sean X Leng; Brock A Beamer; Jeremy Walston
Glutathione peroxidase enzyme activity in aging.
The journals of gerontology. Series A, Biological sciences and medical sciences 2008;63(5):505-9.
2008: Umberto De Fanis; George C Wang; Neal S Fedarko; Jeremy Walston; Vincenzo Casolaro; Sean X Leng
T-lymphocytes expressing CC chemokine receptor-5 are increased in frail older adults.
Journal of the American Geriatrics Society 2008;56(5):904-8.
2008: Jeremy Walston; Neal S Fedarko; Huanle Yang; Sean X Leng; Brock A Beamer; Sara Espinoza; Anne Lipton; Howie Zheng; Kevin Becker
The physical and biological characterization of a frail mouse model.
The journals of gerontology. Series A, Biological sciences and medical sciences 2008;63(4):391-8.
2008: Sean X Leng; XINPING TIAN; Samuel C Durso; GERALD LAZARUS; Chongmei Lu; EUNMI PARK; Haiyan Xie; Lin Kang; Dongjing Li; Ti Shen; Linda P Fried
The aging population and development of geriatrics in China.
Journal of the American Geriatrics Society 2008;56(3):571-3.
2007: Sean X Leng; Thomas Finucane; Lisa Boult; Larry Zheng; William B Greenough
Inadvertent self-healing in desperate times.
Lancet 2007;370(9596):1458.
2007: Sean X Leng; Qian-Li Xue; Jing Tian; Jeremy Walston; Linda P Fried
Inflammation and frailty in older women.
Journal of the American Geriatrics Society 2007;55(6):864-71.
2006: Anne R Cappola; Qian-Li Xue; Jeremy Walston; Sean X Leng; Luigi Ferrucci; Jack Guralnik; Linda P Fried
DHEAS levels and mortality in disabled older women: the Women's Health and Aging Study I.
The journals of gerontology. Series A, Biological sciences and medical sciences 2006;61(9):957-62.
2005: Sean X Leng; Qian-Li Xue; Yi Huang; Luigi Ferrucci; Linda P Fried; Jeremy Walston
Baseline total and specific differential white blood cell counts and 5-year all-cause mortality in community-dwelling older women.
Experimental gerontology 2005;40(12):982-7.
2005: Paulo H M Chaves; Richard D Semba; Sean X Leng; Richard C Woodman; Luigi Ferrucci; Jack M Guralnik; Linda P Fried
Impact of anemia and cardiovascular disease on frailty status of community-dwelling older women: the Women's Health and Aging Studies I and II.
The journals of gerontology. Series A, Biological sciences and medical sciences 2005;60(6):729-35.
2005: Heidi N Schmaltz; Linda P Fried; Qian-Li Xue; Jeremy Walston; Sean X Leng; Richard D Semba
Chronic cytomegalovirus infection and inflammation are associated with prevalent frailty in community-dwelling older women.
Journal of the American Geriatrics Society 2005;53(5):747-54.
2005: Sean X Leng; Qian-Li Xue; Yi Huang; Richard D Semba; Paulo H M Chaves; Karen Bandeen-Roche; Linda P Fried; Jeremy Walston
Total and differential white blood cell counts and their associations with circulating interleukin-6 levels in community-dwelling older women.
The journals of gerontology. Series A, Biological sciences and medical sciences 2005;60(2):195-9.
2005: Richard D Semba; Joseph B Margolick; Sean X Leng; Jeremy Walston; Michelle O Ricks; Linda P Fried
T cell subsets and mortality in older community-dwelling women.
Experimental gerontology 2005;40(1-2):81-7.
2004: Sean X Leng; Huanle Yang; Jeremy Walston
Decreased cell proliferation and altered cytokine production in frail older adults.
Aging clinical and experimental research 2004;16(3):249-52.
2004: Sean X Leng; Anne R Cappola; Ross E Andersen; Marc R Blackman; Kathleen Koenig; Michael P Blair; Jeremy Walston
Serum levels of insulin-like growth factor-I (IGF-I) and dehydroepiandrosterone sulfate (DHEA-S), and their relationships with serum interleukin-6, in the geriatric syndrome of frailty.
Aging clinical and experimental research 2004;16(2):153-7.
2002: Sean X Leng; Paulo H M Chaves; Kathleen Koenig; Jeremy Walston
Serum interleukin-6 and hemoglobin as physiological correlates in the geriatric syndrome of frailty: a pilot study.
Journal of the American Geriatrics Society 2002;50(7):1268-71.
2000: Sean X Leng; E Erim; R McShine; P A Bloom; D P Kotler
Influence of medical illness on body composition and quality of life in geriatric outpatients: a pilot study.
Journal of the American Geriatrics Society 2000;48(12):1737-8.