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Catherine Léon

Research Profile

Chemicals & Drugs

Anatomy

Physiology

Platelet Aggregation

Living Beings

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Drug Dose Response Relationship

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Publications

TOP 3
Catherine Léon; Fabien Pertuy; Patricia Laeuffer; Frank Dombrowski; Anita Eckly; Katja Evert; Christian Gachet; Andreas Greinacher
Romiplostim administration shows reduced megakaryocyte response-capacity and increased myelofibrosis in a mouse model of MYH9-RD.
Anita Eckly; François Lanza; Catherine Léon; Catherine Strassel; Jean-Pierre Cazenave; Christian Gachet
Characterization of megakaryocyte development in the native bone marrow environment.
Catherine Strassel; Catherine Léon; Sylvie Moog; Jean-Pierre Cazenave; Anita Eckly; Christian Gachet; François Lanza
Hirudin and heparin enable efficient megakaryocyte differentiation of mouse bone marrow progenitors.

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2012: Catherine Léon; Fabien Pertuy; Patricia Laeuffer; Frank Dombrowski; Anita Eckly; Katja Evert; Christian Gachet; Andreas Greinacher
Romiplostim administration shows reduced megakaryocyte response-capacity and increased myelofibrosis in a mouse model of MYH9-RD.
Blood 2012;119(14):3333-41.
2012: Anita Eckly; François Lanza; Catherine Léon; Catherine Strassel; Jean-Pierre Cazenave; Christian Gachet
Characterization of megakaryocyte development in the native bone marrow environment.
Methods in molecular biology (Clifton, N.J.) 2012;788():175-92.
2012: Catherine Strassel; Catherine Léon; Sylvie Moog; Jean-Pierre Cazenave; Anita Eckly; Christian Gachet; François Lanza
Hirudin and heparin enable efficient megakaryocyte differentiation of mouse bone marrow progenitors.
Experimental cell research 2012;318(1):25-32.
2007: Catherine Léon; Anita Eckly; Béatrice Hechler; Boris Aleil; Monique Freund; Catherine Ravanat; Marie Jourdain; christelle nonne; Josiane Weber; Ralph Tiedt; Marie-Pierre Gratacap; Sonia Severin; Jean-Pierre Cazenave; François Lanza; Radek C Skoda; Christian Gachet
Megakaryocyte-restricted MYH9 inactivation dramatically affects hemostasis while preserving platelet aggregation and secretion.
Blood 2007;110(9):3183-91.
2006: Christian Gachet; Catherine Léon; Béatrice Hechler
The platelet P2 receptors in arterial thrombosis.
Blood cells, molecules & diseases 2006;36(2):223-7.
2005: Catherine Léon; Monique Freund; Olivier Latchoumanin; Anne Farret; Pierre Petit; Jean-Pierre Cazenave; Christian Gachet
The P2Y(1) receptor is involved in the maintenance of glucose homeostasis and in insulin secretion in mice.
Purinergic signalling 2005;1(2):145-51.
2005: Anthony Baurand; Anita Eckly; Béatrice Hechler; Gilles kauffenstein; Jean-Luc Galzi; Jean-Pierre Cazenave; Catherine Léon; Christian Gachet
Differential regulation and relocalization of the platelet P2Y receptors after activation: a way to avoid loss of hemostatic properties?
Molecular pharmacology 2005;67(3):721-33.
2003: Nadège Lenain; Monique Freund; Catherine Léon; Jean-Pierre Cazenave; Christian Gachet
Inhibition of localized thrombosis in P2Y1-deficient mice and rodents treated with MRS2179, a P2Y1 receptor antagonist.
Journal of thrombosis and haemostasis : JTH 2003;1(6):1144-9.
2001: Gilles kauffenstein; Wolfgang Bergmeier; Anita Eckly; Philippe Ohlmann; Catherine Léon; Jean-Pierre Cazenave; Bernhard Nieswandt; Christian Gachet
The P2Y(12) receptor induces platelet aggregation through weak activation of the alpha(IIb)beta(3) integrin--a phosphoinositide 3-kinase-dependent mechanism.
FEBS letters 2001;505(2):281-90.
2001: Catherine Léon; Monique Freund; Catherine Ravanat; Anthony Baurand; Jean-Pierre Cazenave; Christian Gachet
Key role of the P2Y(1) receptor in tissue factor-induced thrombin-dependent acute thromboembolism: studies in P2Y(1)-knockout mice and mice treated with a P2Y(1) antagonist.
Circulation 2001;103(5):718-23.
2001: Anthony Baurand; Pierre Raboisson; Monique Freund; Catherine Léon; Jean-Pierre Cazenave; Jean-Jacques Bourguignon; Christian Gachet
Inhibition of platelet function by administration of MRS2179, a P2Y1 receptor antagonist.
European journal of pharmacology 2001;412(3):213-21.
2000: Anthony Baurand; Anita Eckly; N Bari; Catherine Léon; Béatrice Hechler; Jean-Pierre Cazenave; Christian Gachet
Desensitization of the platelet aggregation response to ADP: differential down-regulation of the P2Y1 and P2cyc receptors.
Thrombosis and haemostasis 2000;84(3):484-91.
1999: Catherine Léon; Béatrice Hechler; Monique Freund; Anita Eckly; C Vial; Philippe Ohlmann; Andrée Dierich; Marianne LeMeur; Jean-Pierre Cazenave; Christian Gachet
Defective platelet aggregation and increased resistance to thrombosis in purinergic P2Y(1) receptor-null mice.
The Journal of clinical investigation 1999;104(12):1731-7.
1999: Catherine Léon; C Vial; Christian Gachet; Philippe Ohlmann; Béatrice Hechler; Jean-Pierre Cazenave; A Lecchi; M Cattaneo
The P2Y1 receptor is normal in a patient presenting a severe deficiency of ADP-induced platelet aggregation.
Thrombosis and haemostasis 1999;81(5):775-81.
1998: Béatrice Hechler; Catherine Léon; C Vial; Paul Vigne; Christian Frelin; Jean-Pierre Cazenave; Christian Gachet
The P2Y1 receptor is necessary for adenosine 5'-diphosphate-induced platelet aggregation.
Blood 1998;92(1):152-9.
1998: Béatrice Hechler; Paul Vigne; Catherine Léon; Jean-Philippe Breittmayer; Christian Gachet; Christian Frelin
ATP derivatives are antagonists of the P2Y1 receptor: similarities to the platelet ADP receptor.
Molecular pharmacology 1998;53(4):727-33.
1997: C Vial; Béatrice Hechler; Catherine Léon; Jean-Pierre Cazenave; Christian Gachet
Presence of P2X1 purinoceptors in human platelets and megakaryoblastic cell lines.
Thrombosis and haemostasis 1997;78(6):1500-4.
1997: Christian Gachet; Béatrice Hechler; Catherine Léon; C Vial; C Leray; Philippe Ohlmann; Jean-Pierre Cazenave
Activation of ADP receptors and platelet function.
Thrombosis and haemostasis 1997;78(1):271-5.
1997: Catherine Léon; Béatrice Hechler; C Vial; C Leray; Jean-Pierre Cazenave; Christian Gachet
The P2Y1 receptor is an ADP receptor antagonized by ATP and expressed in platelets and megakaryoblastic cells.
FEBS letters 1997;403(1):26-30.
1996: Catherine Léon; C Vial; Jean-Pierre Cazenave; Christian Gachet
Cloning and sequencing of a human cDNA encoding endothelial P2Y1 purinoceptor.
Gene 1996;171(2):295-7.