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Leonor Leon

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Karen S Charret; Adriana O Gomes; Cristiane F Hottz; Jussara Lagrota-Cândido; Leonor L Leon; Marie-Luce F Lira; Raquel F Rodrigues; Alice Maria Rolim Bernardino; Marilene M Canto-Cavalheiro; Carla E Carvalho-Pinto; Veronica F Amaral
The histopathological and immunological pattern of CBA mice infected with Leishmania amazonensis after treatment with pyrazole carbohydrazide derivatives.
Ananda de Castro Cunha; Regina Aparecida Correia Gonçalves; Leonor L Leon; Gerzia Maria de Carvalho Machado; Julio Cesar Tanaka; Cleuza Conceição da Silva; Talita Perez Cantuaria Chierrito; Lauro Mera de Souza; Arildo José Braz de Oliveira
Anti-leishmanial activity of alkaloidal extracts obtained from different organs of Aspidosperma ramiflorum.
Daniel Ignacchiti Lacerda; Leonor L Leon; Denise Cristina de Souza Matos; Marco Alberto Medeiros; Leila Mendonça-Lima; Marise P Nunes; Marcia Berrêdo-Pinho; Léa Cysne-Finkelstein; Paula Mello De-Luca; Marcelo da Silva Genestra; Sergio C F Mendonça
Kinetoplastid membrane protein-11 exacerbates infection with Leishmania amazonensis in murine macrophages.

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All Publications

2013: Karen S Charret; Adriana O Gomes; Cristiane F Hottz; Jussara Lagrota-Cândido; Leonor L Leon; Marie-Luce F Lira; Raquel F Rodrigues; Alice Maria Rolim Bernardino; Marilene M Canto-Cavalheiro; Carla E Carvalho-Pinto; Veronica F Amaral
The histopathological and immunological pattern of CBA mice infected with Leishmania amazonensis after treatment with pyrazole carbohydrazide derivatives.
Experimental parasitology 2013;133(2):201-10.
2012: Ananda de Castro Cunha; Regina Aparecida Correia Gonçalves; Leonor L Leon; Gerzia Maria de Carvalho Machado; Julio Cesar Tanaka; Cleuza Conceição da Silva; Talita Perez Cantuaria Chierrito; Lauro Mera de Souza; Arildo José Braz de Oliveira
Anti-leishmanial activity of alkaloidal extracts obtained from different organs of Aspidosperma ramiflorum.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2012;19(5):413-7.
2012: Daniel Ignacchiti Lacerda; Leonor L Leon; Denise Cristina de Souza Matos; Marco Alberto Medeiros; Leila Mendonça-Lima; Marise P Nunes; Marcia Berrêdo-Pinho; Léa Cysne-Finkelstein; Paula Mello De-Luca; Marcelo da Silva Genestra; Sergio C F Mendonça
Kinetoplastid membrane protein-11 exacerbates infection with Leishmania amazonensis in murine macrophages.
Memórias do Instituto Oswaldo Cruz 2012;107(2):238-45.
2012: Raquel F Rodrigues; Carlos Mauricio R Sant'Anna; Filipa Teixeira; Marilene M Canto-Cavalheiro; Helena Castro; Denise Castro-Pinto; Catarina N Del Cistia; Camilla M dos Reis; Aurea Echevarria; Leonor L Leon; Ana Tomás
Investigation of trypanothione reductase inhibitory activity by 1,3,4-thiadiazolium-2-aminide derivatives and molecular docking studies.
Bioorganic & medicinal chemistry 2012;20(5):1760-6.
2012: Roberta K F Marra; Cesar D Oliveira; Tathiane A Proux; Carlos R Rodrigues; Alessandra M T Souza; Alice Maria Rolim Bernardino; Júlio C Borges; Marilene M Canto-Cavalheiro; Helena C Castro; Karen S Charret; Leonor L Leon; Marie-Luce F Lira; Veronica F Amaral
4-(1H-Pyrazol-1-yl) benzenesulfonamide derivatives: identifying new active antileishmanial structures for use against a neglected disease.
Molecules (Basel, Switzerland) 2012;17(11):12961-73.
2012: Dominique F Moura do Carmo; Ana Cláudia Fernandes Amaral; Leonor L Leon; Gérzia M C Machado; Jefferson Rocha de Andrade Silva
Chemical and biological analyses of the essential oils and main constituents of Piper species.
Molecules (Basel, Switzerland) 2012;17(2):1819-29.
2011: Maurício S dos Santos; Leonor L Leon; Mariana L V Oliveira; Veronica F Amaral; Alice M R Bernardino; Flavia T de Carvalho; Rosa M de Léo; Marilene M Canto-Cavalheiro
Synthesis and antileishmanial evaluation of 1-aryl-4-(4,5-dihydro-1H-imidazol-2-yl)-1H-pyrazole derivatives.
Bioorganic & medicinal chemistry letters 2011;21(24):7451-4.
2011: Renata O A Soares; Gérzia M Machado; Rosa T Pinho; Wellingon S Seguins; Myrtes S S Bellieny; Marilene M Canto-Cavalheiro; Rosa M M de Leo; Aurea Echevarria; Leonor L Leon
Evaluation of thiosemicarbazones and semicarbazones as potential agents anti-Trypanosoma cruzi.
Experimental parasitology 2011;129(4):381-7.
2011: Daniela Fabrino; Leonor L Leon; Marcelo Genestra; Gleydes G Parreira; Rossana C N Melo
Rat models to investigate host macrophage defense against Trypanosoma cruzi.
Journal of innate immunity 2011;3(1):71-82.
2010: Monica C O Campos; Kelly Salomão; Denise B Castro-Pinto; Leonor L Leon; Helene Santos Barbosa; Maria Aparecida M Maciel; Solange L de Castro
Croton cajucara crude extract and isolated terpenes: activity on Trypanosoma cruzi.
Parasitology research 2010;107(5):1193-204.
2009: Karen S Charret; Raquel F Rodrigues; Alice M R Bernardino; Adriana O Gomes; Adriana V Carvalho; Marilene M Canto-Cavalheiro; Leonor L Leon; Veronica F Amaral
Effect of oral treatment with pyrazole carbohydrazide derivatives against murine infection by Leishmania amazonensis.
The American journal of tropical medicine and hygiene 2009;80(4):568-73.
2009: Nubia Matta; Ricardo S Nogueira; Antonia M R Franco; Ilner de Souza E Souza; Marise S Mattos; Manoel Paes Oliveira-Neto; Sergio G Coutinho; Leonor L Leon; Alda Maria Da-Cruz
Leishmania (Viannia) guyanensis induces low immunologic responsiveness in leishmaniasis patients from an endemic area of the Brazilian Amazon Highland.
The American journal of tropical medicine and hygiene 2009;80(3):339-44.
2009: Raquel F Rodrigues; Karen S Charret; Edson F da Silva; Aurea Echevarria; Verônica F Amaral; Leonor L Leon; Marilene M Canto-Cavalheiro
Antileishmanial activity of 1,3,4-thiadiazolium-2-aminide in mice infected with Leishmania amazonensis.
Antimicrobial agents and chemotherapy 2009;53(2):839-42.
2008: Marcelo Genestra; Rômulo José Soares-Bezerra; Liliane Gomes-Silva; Daniela Fabrino; Thiago Bellato-Santos; Denise Barçante Castro-Pinto; Marilene M Canto-Cavalheiro; Leonor L Leon
In vitro sodium nitroprusside-mediated toxicity towards Leishmania amazonensis promastigotes and axenic amastigotes.
Cell biochemistry and function 2008;26(6):709-17.
2008: Rômulo José Soares-Bezerra; Edson F da Silva; Aurea Echevarria; Liliane Gomes-da-Silva; Léa Cysne-Finkelstein; Fabiane Monteiro; Leonor L Leon; Marcelo Genestra
Effect of mesoionic 4-phenyl-5-(cinnamoyl)-1,3,4-thiadiazolium-2-phenylamine chloride derivative salts on the activities of the nitric oxide synthase and arginase of Leishmania amazonensis.
Journal of enzyme inhibition and medicinal chemistry 2008;23(3):328-33.
2008: Denise Barçante Castro-Pinto; Marcelo Genestra; Gustavo B Menezes; Mariana C Waghabi; Antonio Gonçalves; Catarina De Nigris Del Cistia; Carlos Mauricio R Sant'Anna; Leonor L Leon; Leila Mendonça-Lima
Cloning and expression of trypanothione reductase from a New World Leishmania species.
Archives of microbiology 2008;189(4):375-84.
2007: Raquel F Rodrigues; Edson F da Silva; Aurea Echevarria; Renata Fajardo-Bonin; Veronica F Amaral; Leonor L Leon; Marilene M Canto-Cavalheiro
A comparative study of mesoionic compounds in Leishmania sp. and toxicity evaluation.
European journal of medicinal chemistry 2007;42(7):1039-43.
2007: J C A Tanaka; C C da Silva; I C P Ferreira; Gérzia M C Machado; Leonor L Leon; Arildo José Braz de Oliveira
Antileishmanial activity of indole alkaloids from Aspidosperma ramiflorum.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2007;14(6):377-80.
2007: Denise Barçante Castro-Pinto; Edson L S Lima; Andrea S Cunha; Marcelo Genestra; Rosa Maria De Léo; Fabiane Monteiro; Leonor L Leon
Leishmania amazonensis trypanothione reductase: evaluation of the effect of glutathione analogs on parasite growth, infectivity and enzyme activity.
Journal of enzyme inhibition and medicinal chemistry 2007;22(1):71-5.
2007: Gérzia M C Machado; Leonor L Leon; Solange L de Castro
Activity of Brazilian and Bulgarian propolis against different species of Leishmania.
Memórias do Instituto Oswaldo Cruz 2007;102(1):73-7.
2006: Marcelo Genestra; Wilson J S Souza; Damiana Guedes-Silva; Gérzia M C Machado; Léa Cysne-Finkelstein; Rômulo José Soares Bezerra; Fabiane Monteiro; Leonor L Leon
Nitric oxide biosynthesis by Leishmania amazonensis promastigotes containing a high percentage of metacyclic forms.
Archives of microbiology 2006;185(5):348-54.
2006: José E Piñero; Rosane M Temporal; Antonio J Silva-Gonçalves; Ignacio A Jiménez; Isabel L Bazzocchi; Alexis Oliva; Antonio Perera; Leonor L Leon; Basilio Valladares
New administration model of trans-chalcone biodegradable polymers for the treatment of experimental leishmaniasis.
Acta tropica 2006;98(1):59-65.
2006: Marcelo Genestra; Damiana Guedes-Silva; Wilson J S Souza; Léa Cysne-Finkelstein; Rômulo José Soares-Bezerra; Fabiane Monteiro; Leonor L Leon
Nitric oxide synthase (NOS) characterization in Leishmania amazonensis axenic amastigotes.
Archives of medical research 2006;37(3):328-33.
2006: Emmanoel V Costa; Maria Lúcia B Pinheiro; Clahildek M Xavier; Jefferson R A Silva; Ana Cláudia F Amaral; Afonso D L Souza; Andersson Barison; Francinete Ramos Campos; Antonio G Ferreira; Gérzia M C Machado; Leonor L Leon
A pyrimidine-beta-carboline and other alkaloids from Annona foetida with antileishmanial activity.
Journal of natural products 2006;69(2):292-4.
2006: Alice Maria Rolim Bernardino; Adriana O Gomes; Karen S Charret; Antônio C C Freitas; Gérzia M C Machado; Marilene M Canto-Cavalheiro; Leonor L Leon; Veronica F Amaral
Synthesis and leishmanicidal activities of 1-(4-X-phenyl)-N'-[(4-Y-phenyl)methylene]-1H-pyrazole-4-carbohydrazides.
European journal of medicinal chemistry 2006;41(1):80-7.
2005: Rosane M Temporal; Léa Cysne-Finkelstein; Aurea Echevarria; Antonio J Silva-Gonçalves; Leonor L Leon; Marcelo Genestra
Amidine derivatives and Leishmania amazonensis: an evaluation of the effect of nitric oxide (NO) production on the parasite-macrophage interaction.
Journal of enzyme inhibition and medicinal chemistry 2005;20(1):13-8.
2004: Ana O De Souza; F P Hemerly; L Gomes-Cardoso; Ricardo Santa Rita; Leonor L Leon; Solange L de Castro; Nelson Durán
2-propen-1-amine derivatives and their synthetic intermediates: activity against pathogenic trypanosomatids.
Journal of chemotherapy (Florence, Italy) 2004;16(6):530-3.
2004: Nadja M F Lima; Clariane S Correia; Leonor L Leon; Gérzia M C Machado; Maria de Fátima Madeira; Antônio Euzébio G Santana; Marília O F Goulart
Antileishmanial activity of lapachol analogues.
Memórias do Instituto Oswaldo Cruz 2004;99(7):757-61.
2004: Heloisa de Mello; Aurea Echevarria; Alice Maria Rolim Bernardino; Marilene M Canto-Cavalheiro; Leonor L Leon
Antileishmanial pyrazolopyridine derivatives: synthesis and structure-activity relationship analysis.
Journal of medicinal chemistry 2004;47(22):5427-32.
2004: Luciana Vignólio Alves; Léa Cysne-Finkelstein; Rosane M Temporal; Marcelo Genestra; Leonor L Leon
An effective diaryl derivative against Leishmania amazonensis and its influence on the parasite X macrophage interaction.
Journal of enzyme inhibition and medicinal chemistry 2004;19(5):437-9.
2004: Daniela Fabrino; Leonor L Leon; Gleydes G Parreira; Marcelo Genestra; Patrícia Almeida; Rossana C N Melo
Peripheral blood monocytes show morphological pattern of activation and decreased nitric oxide production during acute Chagas' disease in rats.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2004;11(2):166-74.
2004: I C P Ferreira; Maria Valdrinez Campana Lonardoni; Gérzia M C Machado; Leonor L Leon; Lucílio Gobbi Filho; Luís Henrique Bissoli Pinto; Arildo José Braz de Oliveira
Anti-leishmanial activity of alkaloidal extract from Aspidosperma ramiflorum.
Memórias do Instituto Oswaldo Cruz 2004;99(3):325-7.
2004: Denise B Castro-Pinto; Aurea Echevarria; Marcelo Genestra; Léa Cysne-Finkelstein; Leonor L Leon
Trypanothione reductase activity is prominent in metacyclic promastigotes and axenic amastigotes of Leishmania amazonesis. Evaluation of its potential as a therapeutic target.
Journal of enzyme inhibition and medicinal chemistry 2004;19(1):57-63.
2003: Marcelo Genestra; Wilson Jacinto Silva de Souza; Léa Cysne-Finkelstein; Leonor L Leon
Comparative analysis of the nitric oxide production by Leishmania sp.
Medical microbiology and immunology 2003;192(4):217-23.
2003: Marcelo Genestra; Léa Cysne-Finkelstein; Damiana Guedes-Silva; Leonor L Leon
Effect of L-arginine analogs and a calcium chelator on nitric oxide (NO) production by Leishmania sp.
Journal of enzyme inhibition and medicinal chemistry 2003;18(5):445-52.
2003: Luciana Vignólio Alves; Rosane M Temporal; Léa Cysne-Finkelstein; Leonor L Leon
Efficacy of a diarylheptanoid derivative against Leishmania amazonensis.
Memórias do Instituto Oswaldo Cruz 2003;98(4):553-5.
2003: Ana Paula Legey; Ana Paula Pinho; Samanta C C Xavier; Renato S Marchevsky; João Carlos Carreira; Leonor L Leon; Ana Maria Jansen
Trypanosoma cruzi in marsupial didelphids (Philander frenata and Didelhis marsupialis): differences in the humoral immune response in natural and experimental infections.
Revista da Sociedade Brasileira de Medicina Tropical 2003;36(2):241-8.
2003: Marcelo Genestra; Aurea Echevarria; Léa Cysne-Finkelstein; Luciana Vignólio-Alves; Leonor L Leon
Effect of amidine derivatives on nitric oxide production by Leishmania amazonensis promastigotes and axenic amastigotes.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2003;8(1):1-6.
2002: Edson F da Silva; Marilene M Canto-Cavalheiro; Viviane R Braz; Léa Cysne-Finkelstein; Leonor L Leon; Aurea Echevarria
Synthesis, and biological evaluation of new 1,3,4-thiadiazolium-2-phenylamine derivatives against Leishmania amazonensis promastigotes and amastigotes.
European journal of medicinal chemistry 2002;37(12):979-84.
2002: Ana O De Souza; Fernando P Hemerly; Adriana C Busollo; Patricia Silva Melo; Gérzia M C Machado; Cristiana C Miranda; Ricardo Santa Rita; Marcela Haun; Leonor L Leon; Daisy N Sato; Solange L de Castro; Nelson Durán
3-[4'-bromo-(1,1'-biphenyl)-4-yl]-N, N-dimethyl-3-(2-thienyl)-2-propen-1-amine: synthesis, cytotoxicity, and leishmanicidal, trypanocidal and antimycobacterial activities.
The Journal of antimicrobial chemotherapy 2002;50(5):629-37.
2002: Denise de Castro Ferreira Gomes; Leila Vilela Alegrio; Leonor L Leon; maria elena de lima
Total synthesis and anti-leishmanial activity of some curcumin analogues.
Arzneimittel-Forschung 2002;52(9):695-8.
2002: Rosane M Temporal; Léa Cysne-Finkelstein; Aurea Echevarria; Marco A S de Souza; Mônica Sertà; Antônio J da Silva-Gonçalves; Claude Pirmez; Leonor L Leon
Effects of amidine derivatives on parasite-macrophage interaction and evaluation of toxicity.
Arzneimittel-Forschung 2002;52(6):489-93.
2002: Denise de C F Gomes; Leila Vilela Alegrio; maria elena de lima; Leonor L Leon; Catarina A C Araújo
Synthetic derivatives of curcumin and their activity against Leishmania amazonensis.
Arzneimittel-Forschung 2002;52(2):120-4.
2001: Marcelo Genestra; Aurea Echevarria; Léa Cysne-Finkelstein; Leonor L Leon
Protein kinase A of Leishmania amazonensis as a potential target for methoxy-amidine.
Arzneimittel-Forschung 2001;51(11):920-3.
2001: Leonor L Leon; C C Miranda; Ana O De Souza; Nelson Durán
Antileishmanial activity of the violacein extracted from Chromobacterium violaceum.
The Journal of antimicrobial chemotherapy 2001;48(3):449-50.
2001: C C Araújo; Leonor L Leon
Biological activities of Curcuma longa L.
Memórias do Instituto Oswaldo Cruz 2001;96(5):723-8.
1999: C A Araujo; Leila Vilela Alegrio; Delir Corrêa Gomes; M E Lima; L Gomes-Cardoso; Leonor L Leon
Studies on the effectiveness of diarylheptanoids derivatives against Leishmania amazonensis.
Memórias do Instituto Oswaldo Cruz 1999;94(6):791-4.
1999: Ana Paula Legey; Ana Paula Pinho; S C Chagas Xavier; Leonor L Leon; Ana Maria Jansen
Humoral immune response kinetics in Philander opossum and Didelphis marsupialis infected and immunized by Trypanosoma cruzi employing an immunofluorescence antibody test.
Memórias do Instituto Oswaldo Cruz 1999;94(3):371-6.
1999: L Gomes-Cardoso; Aurea Echevarria; F Aguiar-Alves; Ana Maria Jansen; Leonor L Leon
Amidine derivatives are highly effective against Trypanosoma evansi trypomastigotes.
Microbios 1999;100(397):181-7.
1998: Léa Cysne-Finkelstein; Rosane M Temporal; F A Alves; Leonor L Leon
Leishmania amazonensis: long-term cultivation of axenic amastigotes is associated to metacyclogenesis of promastigotes.
Experimental parasitology 1998;89(1):58-62.
1997: Marilene M Canto-Cavalheiro; Aurea Echevarria; C A Araujo; M F Bravo; L H Santos; Ana Maria Jansen; Leonor L Leon
The potential effects of new synthetic drugs against Leishmania amazonensis and Trypanosoma cruzi.
Microbios 1997;90(362):51-60.
1995: Leonor L Leon; M J Soares; R M Temporal
Effects of temperature on promastigotes of several species of Leishmania.
The Journal of eukaryotic microbiology 1995;42(3):219-23.
1994: Leonor L Leon; R M Temporal; M J Soares; G Grimaldi Júnior
Proteinase activities during temperature-induced stage differentiation of species complexes of Leishmania.
Acta tropica 1994;56(4):289-98.
1992: Leonor L Leon; G M Machado; Aldina Barral; L E de Carvalho-Paes; G Grimaldi Júnior
Antigenic differences among Leishmania amazonensis isolates and their relationship with distinct clinical forms of the disease.
Memórias do Instituto Oswaldo Cruz 1992;87(2):229-34.
1991: Ana Maria Jansen; Leonor L Leon; G M Machado; M H da Silva; S M Souza-Leão; M P Deane
Trypanosoma cruzi in the opossum Didelphis marsupialis: parasitological and serological follow-up of the acute infection.
Experimental parasitology 1991;73(3):249-59.
1990: Leonor L Leon; G M Machado; L E Paes; G Grimaldi Júnior
Antigenic differences of Leishmania amazonensis isolates causing diffuse cutaneous leishmaniasis.
Transactions of the Royal Society of Tropical Medicine and Hygiene 1990;84(5):678-80.