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Stéphane Léonce

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Publications

TOP 3
Anizon Fabrice; Golsteyn Roy M; Léonce Stéphane; Pfeiffer Bruno; Prudhomme Michelle
A three-step synthesis from rebeccamycin of an efficient checkpoint kinase 1 inhibitor.
Do Quyên; Tian Wen; Yougnia Rodrigue; Gaslonde Thomas; Pfeiffer Bruno; Pierré Alain; Léonce Stéphane; Kraus-Berthier Laurence; David-Cordonnier Marie-Hélène; Depauw Sabine; Lansiaux Amélie; Mazinghien Romain; Koch Michel; Tillequin François; Michel Sylvie; Dufat Hanh
Synthesis, cytotoxic activity, and DNA binding properties of antitumor cis-1,2-dihydroxy-1,2-dihydrobenzo[b]acronycine cinnamoyl esters.
Gallet Sebastien; Flouquet Nathalie; Carato Pascal; Pfeiffer Bruno; Renard Pierre; Léonce Stéphane; Pierré Alain; Berthelot Pascal; Lebegue Nicolas
Benzopyridooxathiazepine derivatives as novel potent antimitotic agents.

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All Publications

2009: Anizon Fabrice; Golsteyn Roy M; Léonce Stéphane; Pfeiffer Bruno; Prudhomme Michelle
A three-step synthesis from rebeccamycin of an efficient checkpoint kinase 1 inhibitor.
European journal of medicinal chemistry 2009;44(5):2234-8.
2009: Do Quyên; Tian Wen; Yougnia Rodrigue; Gaslonde Thomas; Pfeiffer Bruno; Pierré Alain; Léonce Stéphane; Kraus-Berthier Laurence; David-Cordonnier Marie-Hélène; Depauw Sabine; Lansiaux Amélie; Mazinghien Romain; Koch Michel; Tillequin François; Michel Sylvie; Dufat Hanh
Synthesis, cytotoxic activity, and DNA binding properties of antitumor cis-1,2-dihydroxy-1,2-dihydrobenzo[b]acronycine cinnamoyl esters.
Bioorganic & medicinal chemistry 2009;17(5):1918-27.
2009: Gallet Sebastien; Flouquet Nathalie; Carato Pascal; Pfeiffer Bruno; Renard Pierre; Léonce Stéphane; Pierré Alain; Berthelot Pascal; Lebegue Nicolas
Benzopyridooxathiazepine derivatives as novel potent antimitotic agents.
Bioorganic & medicinal chemistry 2009;17(3):1132-8.
2008: Do Quyên; Thi Mai Huong Doan; Gaslonde Thomas; Pfeiffer Bruno; Léonce Stéphane; Pierré Alain; Michel Sylvie; Tillequin François; Dufat Hanh
Structure-activity relationships in the acronycine and benzo[b]acronycine series: role of the pyran ring.
European journal of medicinal chemistry 2008;43(12):2677-87.
2008: Boutefnouchet Sabrina; Gaboriaud-Kolar Nicolas; Nguyen Tuan Minh; Depauw Sabine; David-Cordonnier Marie-Hélène; Pfeiffer Bruno; Léonce Stéphane; Pierré Alain; Tillequin François; Lallemand Marie-Christine; Michel Sylvie
Synthesis, cytotoxic activity, and mechanism of action of furo[2,3-c]acridin-6-one and benzo[b]furo[3,2-h]acridin-6-one analogues of psorospermin and acronycine.
Journal of medicinal chemistry 2008;51(22):7287-97.
2008: Lefoix Myriam; Coudert Gérard; Routier Sylvain; Pfeiffer Bruno; Caignard Daniel-Henri; Hickman John; Pierré Alain; Golsteyn Roy M; Léonce Stéphane; Bossard Céline; Mérour Jean-Yves
Novel 5-azaindolocarbazoles as cytotoxic agents and Chk1 inhibitors.
Bioorganic & medicinal chemistry 2008;16(9):5303-21.
2008: Conchon Elisabeth; Anizon Fabrice; Aboab Bettina; Golsteyn Roy M; Léonce Stéphane; Pfeiffer Bruno; Prudhomme Michelle
Synthesis, checkpoint kinase 1 inhibitory properties and in vitro antiproliferative activities of new pyrrolocarbazoles.
Bioorganic & medicinal chemistry 2008;16(8):4419-30.
2008: Conchon Elisabeth; Anizon Fabrice; Aboab Bettina; Golsteyn Roy M; Léonce Stéphane; Pfeiffer Bruno; Prudhomme Michelle
Synthesis, in vitro antiproliferative activities, and Chk1 inhibitory properties of pyrrolo[3,4-a]carbazole-1,3-diones, pyrrolo[3,4-c]carbazole-1,3-diones, and 2-aminopyridazino[3,4-a]pyrrolo[3,4-c]carbazole-1,3,4,7-tetraone.
European journal of medicinal chemistry 2008;43(2):282-92.
2008: Jolly Claire; Thoison Odile; Martin Marie-Thérèse; Dumontet Vincent; Gilbert Aline; Pfeiffer Bruno; Léonce Stéphane; Sévenet Thierry; Guéritte Françoise; Litaudon Marc
Cytotoxic turrianes of Kermadecia elliptica from the New Caledonian rainforest.
Phytochemistry 2008;69(2):533-40.
2007: Hugon Bernadette; Anizon Fabrice; Bailly Christian; Golsteyn Roy M; Pierré Alain; Léonce Stéphane; Hickman John; Pfeiffer Bruno; Prudhomme Michelle
Synthesis and biological activities of isogranulatimide analogues.
Bioorganic & medicinal chemistry 2007;15(17):5965-80.
2007: Zhang Ying-Jun; Litaudon Marc; Bousserouel Hadjira; Martin Marie-Therese; Thoison Odile; Léonce Stéphane; Dumontet Vincent; Sévenet Thierry; Guéritte Francoise
Sesquiterpenoids and cytotoxic lignans from the bark of Libocedrus chevalieri.
Journal of natural products 2007;70(8):1368-70.
2007: Lansiaux Amélie; Léonce Stéphane; Kraus-Berthier Laurence; Bal-Mahieu Christine; Mazinghien Romain; Didier Sébastien; David-Cordonnier Marie-Hélène; Hautefaye Patrick; Lavielle Gilbert; Bailly Christian; Hickman John A; Pierré Alain
Novel stable camptothecin derivatives replacing the E-ring lactone by a ketone function are potent inhibitors of topoisomerase I and promising antitumor drugs.
Molecular pharmacology 2007;72(2):311-9.
2007: Gaslonde Thomas; Michel Sylvie; Koch Michel; Pfeiffer Bruno; Léonce Stéphane; Pierré Alain; Tillequin François
Synthesis and cytotoxic activity of dimeric analogs of acronycine in the benzo[b]pyrano[3,2-h]acridin-7-one series.
Chemical & pharmaceutical bulletin 2007;55(5):734-8.
2007: Hénon Hélène; Messaoudi Samir; Anizon Fabrice; Aboab Bettina; Kucharczyk Nathalie; Léonce Stéphane; Golsteyn Roy M; Pfeiffer Bruno; Prudhomme Michelle
Bis-imide granulatimide analogues as potent Checkpoint 1 kinase inhibitors.
European journal of pharmacology 2007;554(2-3):106-12.
2006: Conchon Elisabeth; Aboab Bettina; Golsteyn Roy M; Cruzalegui Francisco; Edmonds Thomas; Léonce Stéphane; Pfeiffer Bruno; Prudhomme Michelle
Synthesis, in vitro antiproliferative activities, and Chk1 inhibitory properties of indolylpyrazolones and indolylpyridazinedione.
European journal of medicinal chemistry 2006;41(12):1470-7.
2006: Messaoudi Samir; Anizon Fabrice; Peixoto Paul; David-Cordonnier Marie-Hélène; Golsteyn Roy M; Léonce Stéphane; Pfeiffer Bruno; Prudhomme Michelle
Synthesis and biological activities of 7-aza rebeccamycin analogues bearing the sugar moiety on the nitrogen of the pyridine ring.
Bioorganic & medicinal chemistry 2006;14(22):7551-62.
2006: Borgne A; Versteege I; Mahé M; Studeny A; Léonce S; Naime I; Rodriguez M; Hickman J A; Meijer L; Golsteyn R M
Analysis of cyclin B1 and CDK activity during apoptosis induced by camptothecin treatment.
Oncogene 2006;25(56):7361-72.
2006: Léonce Stéphane; Kraus-Berthier Laurence; Golsteyn Roy M; David-Cordonnier Marie-Hélène; Tardy Christelle; Lansiaux Amélie; Poindessous Virginie; Larsen Annette K; Pierré Alain
Generation of replication-dependent double-strand breaks by the novel N2-G-alkylator S23906-1.
Cancer research 2006;66(14):7203-10.
2006: Nguyen Tuan Minh; Sittisombut Chavalit; Boutefnouchet Sabrina; Lallemand Marie-Christine; Michel Sylvie; Koch Michel; Tillequin François; Mazinghien Romain; Lansiaux Amélie; David-Cordonnier Marie-Hélène; Pfeiffer Bruno; Kraus-Berthier Laurence; Léonce Stéphane; Pierré Alain
Synthesis, antitumor activity, and mechanism of action of benzo[a]pyrano[3,2-h]acridin-7-one analogues of acronycine.
Journal of medicinal chemistry 2006;49(11):3383-94.
2006: Hénon Hélène; Anizon Fabrice; Golsteyn Roy M; Léonce Stéphane; Hofmann Robert; Pfeiffer Bruno; Prudhomme Michelle
Synthesis and biological evaluation of new dipyrrolo[3,4-a:3,4-c]carbazole-1,3,4,6-tetraones, substituted with various saturated and unsaturated side chains via palladium catalyzed cross-coupling reactions.
Bioorganic & medicinal chemistry 2006;14(11):3825-34.
2006: Guillaumel Jean; Léonce Stéphane; Pierré Alain; Renard Pierre; Pfeiffer Bruno; Arimondo Paola B; Monneret Claude
Synthesis and biological activity of 6H-isoindolo[2,1-a]indol-6-ones, analogues of batracylin, and related compounds.
European journal of medicinal chemistry 2006;41(3):379-86.
2006: Bouissane L; El Kazzouli S; Léonce S; Pfeiffer B; Rakib E M; Khouili M; Guillaumet G
Synthesis and biological evaluation of N-(7-indazolyl)benzenesulfonamide derivatives as potent cell cycle inhibitors.
Bioorganic & medicinal chemistry 2006;14(4):1078-88.
2005: Lebegue Nicolas; Gallet Sebastien; Flouquet Nathalie; Carato Pascal; Pfeiffer Bruno; Renard Pierre; Léonce Stéphane; Pierré Alain; Chavatte Philippe; Berthelot Pascal
Novel benzopyridothiadiazepines as potential active antitumor agents.
Journal of medicinal chemistry 2005;48(23):7363-73.
2005: Messaoudi Samir; Anizon Fabrice; Léonce Stéphane; Pierré Alain; Pfeiffer Bruno; Prudhomme Michelle
Synthesis and cytotoxicities of 7-aza rebeccamycin analogues bearing various substituents on the sugar moiety, on the imide nitrogen and on the carbazole framework.
European journal of medicinal chemistry 2005;40(10):961-71.
2005: Doan Thi Mai Huong; Gaslonde Thomas; Michel Sylvie; Koch Michel; Tillequin François; Bailly Christian; David-Cordonnier Marie-Hélène; Pfeiffer Bruno; Léonce Stéphane; Pierré Alain
Design, synthesis, and cytotoxic activity of Michael acceptors and enol esters in the benzo[b]acronycine series.
Chemical & pharmaceutical bulletin 2005;53(8):919-22.
2005: Laronze M; Boisbrun M; Léonce S; Pfeiffer B; Renard P; Lozach O; Meijer L; Lansiaux A; Bailly C; Sapi J; Laronze J-Y
Synthesis and anticancer activity of new pyrrolocarbazoles and pyrrolo-beta-carbolines.
Bioorganic & medicinal chemistry 2005;13(6):2263-83.
2005: Duca Maria; Arimondo Paola B; Léonce Stéphane; Pierré Alain; Pfeiffer Bruno; Monneret Claude; Dauzonne Daniel
Novel carbamate derivatives of 4-beta-amino-4'-O-demethyl-4-desoxypodophyllotoxin as inhibitors of topoisomerase II: synthesis and biological evaluation.
Organic & biomolecular chemistry 2005;3(6):1074-80.
2005: Routier Sylvain; Peixoto Paul; Mérour Jean-Yves; Coudert Gérard; Dias Nathalie; Bailly Christian; Pierré Alain; Léonce Stéphane; Caignard Daniel-Henry
Synthesis and biological evaluation of novel naphthocarbazoles as potential anticancer agents.
Journal of medicinal chemistry 2005;48(5):1401-13.
2005: Duca Maria; Guianvarc'h Dominique; Meresse Philippe; Bertounesque Emmanuel; Dauzonne Daniel; Kraus-Berthier Laurence; Thirot Sylvie; Léonce Stéphane; Pierré Alain; Pfeiffer Bruno; Renard Pierre; Arimondo Paola B; Monneret Claude
Synthesis and biological study of a new series of 4'-demethylepipodophyllotoxin derivatives.
Journal of medicinal chemistry 2005;48(2):593-603.
2005: Guillonneau Claude; Nault Annette; Raimbaud Eric; Léonce Stéphane; Kraus-Berthier Laurence; Pierré Alain; Goldstein Solo
Cytotoxic and antitumoral properties in a series of new, ring D modified, olivacine analogues.
Bioorganic & medicinal chemistry 2005;13(1):175-84.
2004: Bal Christine; Baldeyrou Brigitte; Moz Florence; Lansiaux Amélie; Colson Pierre; Kraus-Berthier Laurence; Léonce Stéphane; Pierré Alain; Boussard Marie-Françoise; Rousseau Anne; Wierzbicki Michel; Bailly Christian
Novel antitumor indenoindole derivatives targeting DNA and topoisomerase II.
Biochemical pharmacology 2004;68(10):1911-22.
2004: Prado Soizic; Michel Sylvie; Tillequin François; Koch Michel; Pfeiffer Bruno; Pierré Alain; Léonce Stéphane; Colson Pierre; Baldeyrou Brigitte; Lansiaux Amélie; Bailly Christian
Synthesis and cytotoxic activity of benzo[c][1,7] and [1,8]phenanthrolines analogues of nitidine and fagaronine.
Bioorganic & medicinal chemistry 2004;12(14):3943-53.
2004: Guianvarc'h Dominique; Duca Maria; Boukarim Chawki; Kraus-Berthier Laurence; Léonce Stéphane; Pierré Alain; Pfeiffer Bruno; Renard Pierre; Arimondo Paola B; Monneret Claude; Dauzonne Daniel
Synthesis and biological activity of sulfonamide derivatives of epipodophyllotoxin.
Journal of medicinal chemistry 2004;47(9):2365-74.
2004: Voldoire Aline; Moreau Pascale; Sancelme Martine; Matulova Maria; Léonce Stéphane; Pierré Alain; Hickman John; Pfeiffer Bruno; Renard Pierre; Dias Nathalie; Bailly Christian; Prudhomme Michelle
Analogues of antifungal tjipanazoles from rebeccamycin.
Bioorganic & medicinal chemistry 2004;12(8):1955-62.
2004: David-Cordonnier Marie-Hélène; Laine William; Gaslonde Thomas; Michel Sylvie; Tillequin Francois; Koch Michel; Léonce Stéphane; Pierré Alain; Bailly Christian
Design of novel antitumor DNA alkylating agents: the benzacronycine series.
Current medicinal chemistry. Anti-cancer agents 2004;4(2):83-92.
2004: Lisowski Vincent; Léonce Stéphane; Kraus-Berthier Laurence; Sopková-de Oliveira Santos Jana; Pierré Alain; Atassi Ghanem; Caignard Daniel-Henri; Renard Pierre; Rault Sylvain
Design, synthesis, and evaluation of novel thienopyrrolizinones as antitubulin agents.
Journal of medicinal chemistry 2004;47(6):1448-64.
2004: Doan Thi Mai Huong; Gaslonde Thomas; Michel Sylvie; Koch Michel; Tillequin François; Pfeiffer Bruno; Renard Pierre; Kraus-Berthier Laurence; Léonce Stéphane; Pierré Alain
Synthesis and cytotoxic and antitumor activity of 1,2-dihydroxy-1,2-dihydrobenzo[b]acronycine diacid hemiesters and carbamates.
Chemical & pharmaceutical bulletin 2004;52(3):293-7.
2004: Blanchard Stéphanie; Rodriguez Ivan; Tardy Christelle; Baldeyrou Brigitte; Bailly Christian; Colson Pierre; Houssier Claude; Léonce Stéphane; Kraus-Berthier Laurence; Pfeiffer Bruno; Renard Pierre; Pierré Alain; Caubère Paul; Guillaumet Gérald
Synthesis of mono- and bisdihydrodipyridopyrazines and assessment of their DNA binding and cytotoxic properties.
Journal of medicinal chemistry 2004;47(4):978-87.
2004: David-Cordonnier Marie Hélène; Laine William; Kouach Mostafa; Briand Gilbert; Vezin Hervé; Gaslonde Thomas; Michel Sylvie; Doan Thi Mai Huong; Tillequin Francois; Koch Michel; Léonce Stéphane; Pierré Alain; Bailly Christian
A transesterification reaction is implicated in the covalent binding of benzo[b]acronycine anticancer agents with DNA and glutathion.
Bioorganic & medicinal chemistry 2004;12(1):23-9.
2003: Hautefaye Patrick; Cimetière Bernard; Pierré Alain; Léonce Stéphane; Hickman John; Laine William; Bailly Christian; Lavielle Gilbert
Synthesis and pharmacological evaluation of novel non-lactone analogues of camptothecin.
Bioorganic & medicinal chemistry letters 2003;13(16):2731-5.
2003: Thi Mai Huong Doan; Gaslonde Thomas; Michel Sylvie; Tillequin François; Koch Michel; Bongui Jean-Bernard; Elomri Abdelhakim; Seguin Elisabeth; Pfeiffer Bruno; Renard Pierre; David-Cordonnier Marie-Hélène; Laine William; Bailly Christian; Kraus-Berthier Laurence; Léonce Stéphane; Hickman John A; Pierré Alain
Structure-activity relationships and mechanism of action of antitumor benzo[b]pyrano[3,2-h]acridin-7-one acronycine analogues.
Journal of medicinal chemistry 2003;46(14):3072-82.
2003: Marminon Christelle; Pierré Alain; Pfeiffer Bruno; Pérez Valérie; Léonce Stéphane; Renard Pierre; Prudhomme Michelle
Syntheses and antiproliferative activities of rebeccamycin analogues bearing two 7-azaindole moieties.
Bioorganic & medicinal chemistry 2003;11(5):679-87.
2003: Marminon Christelle; Pierré Alain; Pfeiffer Bruno; Pérez Valérie; Léonce Stéphane; Joubert Alexandra; Bailly Christian; Renard Pierre; Hickman John; Prudhomme Michelle
Syntheses and antiproliferative activities of 7-azarebeccamycin analogues bearing one 7-azaindole moiety.
Journal of medicinal chemistry 2003;46(4):609-22.
2003: Guillaumel Jean; Léonce Stéphane; Pierré Alain; Renard Pierre; Pfeiffer Bruno; Peruchon Laure; Arimondo Paola B; Monneret Claude
Synthesis and antiproliferative activity of basic ethers of 1,2-dihydropyrrolo[1,2-a]indole, 6H-isoindolo[2,1-a]indole, and 6H-benz[5,6]isoindolo[2,1-a]indole.
Oncology research 2003;13(12):537-49.
2003: Costes Nadine; Elomri Abdelhakim; Dufat Hanh; Michel Sylvie; Seguin Elisabeth; Koch Michel; Tillequin François; Pfeiffer Bruno; Renard Pierre; Léonce Stéphane; Pierré Alain
Synthesis of 6-dialkylaminoalkylamino pyrano[2,3-c]acridones and benzo[b]pyrano[3,2-h]acridones: soluble acronycine analogues with increased cytotoxic activity.
Oncology research 2003;13(4):191-7.
2002: Jiang Wei-Qun; Charlet-Fagnère Catherine; Sapi Janos; Laronze Jean-Yves; Renard Pierre; Pfeiffer Bruno; Léonce Stéphane
Cytotoxic bis-3,4-dihydro-beta-carbolines and bis-beta-carbolines.
Journal of enzyme inhibition and medicinal chemistry 2002;17(6):369-74.
2002: Couture Axel; Deniau Eric; Grandclaudon Pierre; Rybalko-Rosen Hélène; Léonce Stéphane; Pfeiffer Bruno; Renard Pierre
Synthesis and biological evaluation of aristolactams.
Bioorganic & medicinal chemistry letters 2002;12(24):3557-9.
2002: Bermejo Almudena; Andreu Inmaculada; Suvire Fernando; Léonce Stephane; Caignard Daniel H; Renard Pierre; Pierré Alain; Enriz Ricardo D; Cortes Diego; Cabedo Nuria
Syntheses and antitumor targeting G1 phase of the cell cycle of benzoyldihydroisoquinolines and related 1-substituted isoquinolines.
Journal of medicinal chemistry 2002;45(23):5058-68.
2002: Kraus-Berthier Laurence; Guilbaud Nicolas; Léonce Stéphane; Parker Tracy; Genissel Patrick; Guillonneau Claude; Goldstein Solo; Atassi Ghanem; Pierré Alain
Comparison of the pharmacological profile of an olivacine derivative and a potential prodrug.
Cancer chemotherapy and pharmacology 2002;50(2):95-103.
2002: Roulland Emmanuel; Monneret Claude; Florent Jean-Claude; Bennejean Caroline; Renard Pierre; Léonce Stéphane
Enantioselective synthesis of 12-amino alkylidenecyclopentenone prostaglandins.
The Journal of organic chemistry 2002;67(13):4399-406.
2002: Guilbaud Nicolas; Léonce Stéphane; Tillequin François; Koch Michel; Hickman John A; Pierré Alain
Acronycine derivatives as promising antitumor agents.
Anti-cancer drugs 2002;13(5):445-9.
2002: Kostakis Ioannis K; Magiatis Prokopios; Pouli Nicole; Marakos Panagiotis; Skaltsounis Alexios-Leandros; Pratsinis Harris; Léonce Stephane; Pierré Alain
Design, synthesis, and antiproliferative activity of some new pyrazole-fused amino derivatives of the pyranoxanthenone, pyranothioxanthenone, and pyranoacridone ring systems: a new class of cytotoxic agents.
Journal of medicinal chemistry 2002;45(12):2599-609.
2002: Kluza Jérôme; Lansiaux Amélie; Wattez Nicole; Hildebrand Marie-Paule; Léonce Stéphane; Pierré Alain; Hickman John A; Bailly Christian
Induction of apoptosis in HL-60 leukemia and B16 melanoma cells by the acronycine derivative S23906-1.
Biochemical pharmacology 2002;63(8):1443-52.
2002: Marminon Christelle; Anizon Fabrice; Moreau Pascale; Léonce Stéphane; Pierré Alain; Pfeiffer Bruno; Renard Pierre; Prudhomme Michelle
Syntheses and antiproliferative activities of new rebeccamycin derivatives with the sugar unit linked to both indole nitrogens.
Journal of medicinal chemistry 2002;45(6):1330-9.
2002: Lewin Guy; Hocquemiller Reynald; Schaeffer Corinne; Lambert Pierre-Hervé; Léonce Stéphane; Pierré Alain
Cytotoxicity of 6,16-disubstituted analogues of (-)-vincadifformine.
Bioorganic & medicinal chemistry letters 2002;12(3):371-4.
2001: Léonce S; Pérez V; Lambel S; Peyroulan D; Tillequin F; Michel S; Koch M; Pfeiffer B; Atassi G; Hickman J A; Pierré A
Induction of cyclin E and inhibition of DNA synthesis by the novel acronycine derivative S23906-1 precede the irreversible arrest of tumor cells in S phase leading to apoptosis.
Molecular pharmacology 2001;60(6):1383-91.
2001: Moreau P; Sancelme M; Bailly C; Léonce S; Pierré A; Hickman J; Pfeiffer B; Prudhomme M
Synthesis and biological activities of indolocarbazoles bearing amino acid residues.
European journal of medicinal chemistry 2001;36(11-12):887-97.
2001: Bertrand M; Poissonnet G; Théret-Bettiol M H; Gaspard C; Werner G H; Pfeiffer B; Renard P; Léonce S; Dodd R H
Cytotoxic activities of novel hexahydroindolizino[8,7-b]indole derivatives prepared by 1,3-dipolar cycloaddition reactions of 3,4-dihydro-beta-carboline ylides.
Bioorganic & medicinal chemistry 2001;9(8):2155-64.
2001: Voldoire A; Sancelme M; Prudhomme M; Colson P; Houssier C; Bailly C; Léonce S; Lambel S
Rebeccamycin analogues from indolo[2,3-c]carbazole.
Bioorganic & medicinal chemistry 2001;9(2):357-65.
2001: Raoul M; Schaeffer C; Léonce S; Pierré A; Atassi G; Hocquemiller R; Lewin G
Synthesis of a novel series of cytotoxic bisindole alkaloids.
Bioorganic & medicinal chemistry letters 2001;11(1):79-81.
2001: Li Y; Shan F; Wu J M; Wu G S; Ding J; Xiao D; Yang W Y; Atassi G; Léonce S; Caignard D H; Renard P
Novel antitumor artemisinin derivatives targeting G1 phase of the cell cycle.
Bioorganic & medicinal chemistry letters 2001;11(1):5-8.
2000: Joseph B; Alagille D; Mérour J Y; Léonce S
Synthesis and in vitro cytotoxic evaluation of N-substituted benzo[5,6]cycloheptal[b]indoles.
Chemical & pharmaceutical bulletin 2000;48(12):1872-6.
2000: Graf-Christophe S; Kuehm-Caubère C; Renard P; Pfeiffer B; Pierré A; Léonce S; Caubère P
Synthesis and antiproliferative activity of benzocyclobutacarbazol derivatives. A new class of potential antitumor agents.
Bioorganic & medicinal chemistry letters 2000;10(23):2589-91.
2000: Lamazzi C; Léonce S; Pfeiffer B; Renard P; Guillaumet G; Rees C W; Besson T
Expeditious synthesis and cytotoxic activity of new cyanoindolo[3,2-c]quinolines and benzimidazo[1,2-c]quinazolines.
Bioorganic & medicinal chemistry letters 2000;10(19):2183-5.
2000: Couture A; Deniau E; Grandclaudon P; Lebrun S; Léonce S; Renard P; Pfeiffer B
First synthesis and pharmacological evaluation of benzoindolizidine and benzoquinolizidine analogues of alpha- and beta-peltatin.
Bioorganic & medicinal chemistry 2000;8(8):2113-25.
2000: Costes N; Le Deit H; Michel S; Tillequin F; Koch M; Pfeiffer B; Renard P; Léonce S; Guilbaud N; Kraus-Berthier L; Pierré A; Atassi G
Synthesis and cytotoxic and antitumor activity of benzo[b]pyrano[3, 2-h]acridin-7-one analogues of acronycine.
Journal of medicinal chemistry 2000;43(12):2395-402.
1999: Bermejo A; Léonce S; Cabedo N; Andreu I; Caignard D H; Atassi G; Cortes D
Semisynthesis and cytotoxicity of styryl-lactone derivatives.
Journal of natural products 1999;62(8):1106-9.
1999: Guillonneau C; PierréA; Charton Y; Guilbaud N; Kraus-Berthier L; Léonce S; Michel A; Bisagni E; Atassi G
Synthesis of 9-O-substituted derivatives of 9-hydroxy-5, 6-dimethyl-6H-pyrido[4,3-b]carbazole-1-carboxylic acid (2-(dimethylamino)ethyl)amide and their 10- and 11-methyl analogues with improved antitumor activity.
Journal of medicinal chemistry 1999;42(12):2191-203.
1998: Gonzalez De Peredo A; Léonce S; Monneret C; Dauzonne D
Synthesis and biological evaluation of flavanones and flavones related to podophyllotoxin.
Chemical & pharmaceutical bulletin 1998;46(1):79-83.
1998: Razafimbelo J; Baudouin G; Tillequin F; Renard P; Léonce S; Pierré A; Atassi G
Synthesis and cytotoxic activity of pyranophenanthridine analogues of fagaronine and acronycine.
Chemical & pharmaceutical bulletin 1998;46(1):34-41.
1998: Pierré A; Léonce S; Pérez V; Atassi G
Circumvention of P-glycoprotein-mediated multidrug resistance by S16020-2: kinetics of uptake and efflux in sensitive and resistant cell lines.
Cancer chemotherapy and pharmacology 1998;42(6):454-60.
1997: Morris A D; Léonce S; Guilbaud N; Tucker G C; Pérez V; Jan M; Cordi A A; Pierré A; Atassi G
Eriochrome Black T, structurally related to suramin, inhibits angiogenesis and tumor growth in vivo.
Anti-cancer drugs 1997;8(8):746-55.
1996: Landras C; Jasztold-Howorko R; Pierré A; Léonce S; Guilbaud N; Kraus-Berthier L; Guillonneau C; Rolland Y; Atassi G; Bisagni E
Synthesis and biological evaluation of 6-(9-hydroxy-5-methyl (and 5,6-dimethyl)-6H-pyrido[4,3-b]carbazol-1-yl)picolinic amides as new olivacine derivatives.
Chemical & pharmaceutical bulletin 1996;44(11):2169-72.
1996: Elomri A; Mitaku S; Michel S; Skaltsounis A L; Tillequin F; Koch M; Pierré A; Guilbaud N; Léonce S; Kraus-Berthier L; Rolland Y; Atassi G
Synthesis and cytotoxic and antitumor activity of esters in the 1,2-dihydroxy-1,2-dihydroacronycine series.
Journal of medicinal chemistry 1996;39(24):4762-6.
1996: Léonce S; Perez V; Casabianca-Pignede M R; Anstett M; Bisagni E; Pierré A; Atassi G
In vitro cytotoxicity of S16020-2, a new olivacine derivative.
Investigational new drugs 1996;14(2):169-80.
1995: Léonce S; Pierré A; Atassi G
Flow cytometric evaluation of multidrug-resistance circumvention.
Bulletin du cancer 1995;82(2):114-6.
1994: Jasztold-Howorko R; Landras C; Pierré A; Atassi G; Guilbaud N; Kraus-Berthier L; Léonce S; Rolland Y; Prost J F; Bisagni E
Synthesis and evaluation of 9-hydroxy-5-methyl-(and 5,6-dimethyl)-6H-pyrido[4,3-b]carbazole-1-N- [(dialkylamino)alkyl]carboxamides, a new promising series of antitumor olivacine derivatives.
Journal of medicinal chemistry 1994;37(15):2445-52.
1993: Pérez V; Pierré A; Léonce S; Anstett M; Atassi G
Effect of duration of exposure to S9788, cyclosporin A or verapamil on sensitivity of multidrug resistant cells to vincristine or doxorubicin.
Anticancer research 1993;13(4):985-90.
1993: Pérez V; Pierré A; Léonce S; Anstett M; Prost J F; Atassi G
[In vitro characterization of S9788, a new modulator of multidrug resistance]
Bulletin du cancer 1993;80(4):310-25.
1993: Léonce S; Burbridge M
Flow cytometry: a useful technique in the study of multidrug resistance.
Biology of the cell / under the auspices of the European Cell Biology Organization 1993;78(1-2):63-8.
1992: Léonce S; Pierré A; Anstett M; Pérez V; Genton A; Bizzari J P; Atassi G
Effects of a new triazinoaminopiperidine derivative on adriamycin accumulation and retention in cells displaying P-glycoprotein-mediated multidrug resistance.
Biochemical pharmacology 1992;44(9):1707-15.
1992: Pierré A; Dunn T A; Kraus-Berthier L; Léonce S; Saint-Dizier D; Régnier G; Dhainaut A; Berlion M; Bizzari J P; Atassi G
In vitro and in vivo circumvention of multidrug resistance by Servier 9788, a novel triazinoaminopiperidine derivative.
Investigational new drugs 1992;10(3):137-48.
1992: Dhainaut A; Régnier G; Atassi G; Pierré A; Léonce S; Kraus-Berthier L; Prost J F
New triazine derivatives as potent modulators of multidrug resistance.
Journal of medicinal chemistry 1992;35(13):2481-96.
1992: Pierré A; Pérez V; Léonce S; Boutin J A; Saint-Dizier D; Hautefaye P; Lavielle G; Atassi G
Relationship between the cellular accumulation and the cytotoxicity of S12363, a new Vinca alkaloid derivative.
Cancer chemotherapy and pharmacology 1992;29(5):367-74.

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