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Gustavo Leone

Research Profile

Chemicals & Drugs

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Publications

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Madhu M Ouseph; Thierry Pécot; John C Thompson; Pamela Wenzel; Jing Li; Raghu Machiraju; Morgan Byrne; Hui-Zi Chen; Veda Chokshi; Jean-Leon Chong; Grant Comstock; Alain de Bruin; Braxton Forde; Kun Huang; Gustavo Leone
Atypical E2F repressors and activators coordinate placental development.
Pamela L Wenzel; Jean-Leon Chong; M Teresa Sáenz-Robles; Antoney Ferrey; John Patrick Hagan; Yorman M Gomez; Ravi Rajmohan; Nidhi Sharma; Hui-Zi Chen; James M Pipas; Michael L Robinson; Gustavo Leone
Cell proliferation in the absence of E2F1-3.
Julie A Wallace; Fu Li; Gustavo Leone; Michael C Ostrowski
Pten in the breast tumor microenvironment: modeling tumor-stroma coevolution.

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All Publications

2012: Madhu M Ouseph; Thierry Pécot; John C Thompson; Pamela Wenzel; Jing Li; Raghu Machiraju; Morgan Byrne; Hui-Zi Chen; Veda Chokshi; Jean-Leon Chong; Grant Comstock; Alain de Bruin; Braxton Forde; Kun Huang; Gustavo Leone
Atypical E2F repressors and activators coordinate placental development.
Developmental cell 2012;22(4):849-62.
2011: Pamela L Wenzel; Jean-Leon Chong; M Teresa Sáenz-Robles; Antoney Ferrey; John Patrick Hagan; Yorman M Gomez; Ravi Rajmohan; Nidhi Sharma; Hui-Zi Chen; James M Pipas; Michael L Robinson; Gustavo Leone
Cell proliferation in the absence of E2F1-3.
Developmental biology 2011;351(1):35-45.
2011: Julie A Wallace; Fu Li; Gustavo Leone; Michael C Ostrowski
Pten in the breast tumor microenvironment: modeling tumor-stroma coevolution.
Cancer research 2011;71(4):1203-7.
2011: M Teresa Sáenz-Robles; Ashley Case; Jean-Leon Chong; Gustavo Leone; James M Pipas
The retinoblastoma tumor suppressor regulates a xenobiotic detoxification pathway.
PloS one 2011;6(10):e26019.
2010: Hui Wang; Matt Karikomi; Shan Naidu; Ravi Rajmohan; Enrico Caserta; Hui-Zi Chen; Maysoon Rawahneh; Julie Moffitt; Julie A Stephens; Soledad A Fernandez; Michael Weinstein; Danxin Wang; Wolfgang Sadee; Krista La Perle; Paul Stromberg; Thomas J Rosol; Charis Eng; Michael C Ostrowski; Gustavo Leone
Allele-specific tumor spectrum in pten knockin mice.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(11):5142-7.
2010: Tahera Zabuawala; David A Taffany; Sudarshana M Sharma; Anand Merchant; Brett Adair; Ruchika Srinivasan; Thomas J Rosol; Soledad Fernandez; Kun Huang; Gustavo Leone; Michael C Ostrowski
An ets2-driven transcriptional program in tumor-associated macrophages promotes tumor metastasis.
Cancer research 2010;70(4):1323-33.
2009: Jean-Leon Chong; Pamela L Wenzel; M Teresa Sáenz-Robles; Vivek Nair; Antoney Ferrey; John Patrick Hagan; Yorman M Gomez; Nidhi Sharma; Hui-Zi Chen; Madhu Ouseph; Shu-Huei Wang; Prashant Trikha; Brian Culp; Louise Mezache; Douglas J Winton; Owen J Sansom; Danian Chen; Rod Bremner; Paul G Cantalupo; Michael L Robinson; James M Pipas; Gustavo Leone
E2f1-3 switch from activators in progenitor cells to repressors in differentiating cells.
Nature 2009;462(7275):930-4.
2009: Zahida Qamri; Anju Preet; Mohd W Nasser; Caroline E Bass; Gustavo Leone; Sanford H Barsky; Ramesh K Ganju
Synthetic cannabinoid receptor agonists inhibit tumor growth and metastasis of breast cancer.
Molecular cancer therapeutics 2009;8(11):3117-29.
2009: Hui-Zi Chen; Shih-Yin Tsai; Gustavo Leone
Emerging roles of E2Fs in cancer: an exit from cell cycle control.
Nature reviews. Cancer 2009;9(11):785-97.
2009: Anthony J Trimboli; Carmen Z Cantemir-Stone; Fu Li; Julie A Wallace; Anand Merchant; Nicholas Creasap; John C Thompson; Enrico Caserta; Hui Wang; Jean-Leon Chong; Shan Naidu; Guo Wei; Sudarshana M Sharma; Julie A Stephens; Soledad A Fernandez; Metin N Gurcan; Michael B Weinstein; Sanford H Barsky; Lisa Yee; Thomas J Rosol; PC Stromberg; Michael L Robinson; Francois Pepin; Michael Hallett; Morag Park; Michael C Ostrowski; Gustavo Leone
Pten in stromal fibroblasts suppresses mammary epithelial tumours.
Nature 2009;461(7267):1084-91.
2009: Kishore Mosaliganti; Firdaus Janoos; Okan Irfanoglu; Randall Ridgway; Raghu Machiraju; Kun Huang; Joel Saltz; Gustavo Leone; Michael Ostrowski
Tensor classification of N-point correlation function features for histology tissue segmentation.
Medical image analysis 2009;13(1):156-66.
2009: Ruchika Srinivasan; Tahera Zabuawala; Hong Huang; Jianying Zhang; Parul Gulati; Soledad Fernandez; J Colleen Karlo; Gary E Landreth; Gustavo Leone; Michael C Ostrowski
Erk1 and Erk2 regulate endothelial cell proliferation and migration during mouse embryonic angiogenesis.
PloS one 2009;4(12):e8283.
2009: Jean-Leon Chong; Shih-Yin Tsai; Nidhi Sharma; Rene Opavsky; Richard Price; Lizhao Wu; Soledad A Fernandez; Gustavo Leone
E2f3a and E2f3b contribute to the control of cell proliferation and mouse development.
Molecular and cellular biology 2009;29(2):414-24.
2008: Kishore Mosaliganti; Tony Pan; Randall Ridgway; Richard Sharp; Lee Cooper; Alex Gulacy; Ashish Sharma; Okan Irfanoglu; Raghu Machiraju; Tahsin Kurc; Alain de Bruin; Pamela Wenzel; Gustavo Leone; Joel Saltz; Kun Huang
An imaging workflow for characterizing phenotypical change in large histological mouse model datasets.
Journal of biomedical informatics 2008;41(6):863-73.
2008: Shih-Yin Tsai; Rene Opavsky; Nidhi Sharma; Lizhao Wu; Shan Naidu; Eric Nolan; Enrique Feria-Arias; Cynthia Timmers; Jana Opavska; Alain de Bruin; Jean-Leon Chong; Prashant Trikha; Soledad A Fernandez; PC Stromberg; Thomas J Rosol; Gustavo Leone
Mouse development with a single E2F activator.
Nature 2008;454(7208):1137-41.
2008: Kishore Mosaliganti; Lee Cooper; Richard Sharp; Raghu Machiraju; Gustavo Leone; Kun Huang; Joel Saltz
Reconstruction of cellular biological structures from optical microscopy data.
IEEE transactions on visualization and computer graphics 2008;14(4):863-76.
2008: Kiran S Nadella; Georgette N Jones; Anthony Trimboli; Constantine Straturis; Gustavo Leone; Lawrence S Kirschner
Targeted deletion of Prkar1a reveals a role for protein kinase A in mesenchymal-to-epithelial transition.
Cancer research 2008;68(8):2671-7.
2008: Anthony J Trimboli; Koichi Fukino; Alain de Bruin; Guo Wei; Lei Shen; Stephan M Tanner; Nicholas Creasap; Thomas J Rosol; Michael L Robinson; Charis Eng; Michael C Ostrowski; Gustavo Leone
Direct evidence for epithelial-mesenchymal transitions in breast cancer.
Cancer research 2008;68(3):937-45.
2008: Jing Li; Cong Ran; Edward Li; Faye Martin; Grant Comstock; Hasan Siddiqui; Whitney Cleghorn; Hui-Zi Chen; Karl Kornacker; Chang-gong liu; Shusil K Pandit; Mehrbod Khanizadeh; Michael Weinstein; Gustavo Leone; Alain de Bruin
Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development.
Developmental cell 2008;14(1):62-75.
2007: M Teresa Sáenz-Robles; Jennifer A Markovics; Jean-Leon Chong; Rene Opavsky; Robert H Whitehead; Gustavo Leone; James M Pipas
Intestinal hyperplasia induced by simian virus 40 large tumor antigen requires E2F2.
Journal of virology 2007;81(23):13191-9.
2007: Rene Opavsky; Shih-Yin Tsai; Martin Guimond; Anjulie Arora; Jana Opavska; Brian Becknell; Michael Kaufmann; Nathaniel A Walton; Julie A Stephens; Soledad A Fernandez; Natarajan Muthusamy; Dean W Felsher; Pierluigi Porcu; Michael A Caligiuri; Gustavo Leone
Specific tumor suppressor function for E2F2 in Myc-induced T cell lymphomagenesis.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(39):15400-5.
2007: Rene Opavsky; Shu-Huei Wang; Prashant Trikha; Aparna Raval; Yuan Huang; Yue-Zhong Wu; Benjamin Rodriguez; Benjamin Keller; Sandya Liyanarachchi; Guo Wei; Ramana V Davuluri; Michael Weinstein; Dean W Felsher; Michael Ostrowski; Gustavo Leone; Christoph Plass
CpG island methylation in a mouse model of lymphoma is driven by the genetic configuration of tumor cells.
PLoS genetics 2007;3(9):1757-69.
2007: Kishore Mosaliganti; Firdaus Janoos; Richard Sharp; Randall Ridgway; Raghu Machiraju; Kun Huang; Pamela Wenzel; Alain deBruin; Gustavo Leone; Joel Saltz
Detection and visualization of surface-pockets to enable phenotyping studies.
IEEE transactions on medical imaging 2007;26(9):1283-90.
2007: Pamela L Wenzel; Lizhao Wu; Alain de Bruin; Jean-Leon Chong; Wen-Yi Chen; Geoffrey Dureska; Emily Sites; Tony Pan; Ashish Sharma; Kun Huang; Randall Ridgway; Kishore Mosaliganti; Richard Sharp; Raghu Machiraju; Joel Saltz; Hideyuki Yamamoto; James C Cross; Michael L Robinson; Gustavo Leone
Rb is critical in a mammalian tissue stem cell population.
Genes & development 2007;21(1):85-97.
2007: Cynthia Timmers; Nidhi Sharma; Rene Opavsky; Baidehi Maiti; Lizhao Wu; Juan Wu; Daniel Orringer; Prashant Trikha; Harold I Saavedra; Gustavo Leone
E2f1, E2f2, and E2f3 control E2F target expression and cellular proliferation via a p53-dependent negative feedback loop.
Molecular and cellular biology 2007;27(1):65-78.
2006: Nidhi Sharma; Cynthia Timmers; Prashant Trikha; Harold I Saavedra; Amanda Obery; Gustavo Leone
Control of the p53-p21CIP1 Axis by E2f1, E2f2, and E2f3 is essential for G1/S progression and cellular transformation.
The Journal of biological chemistry 2006;281(47):36124-31.
2006: Adrienne Dorrance; Shujun Liu; Weifeng Yuan; Brian Becknell; Kristy J Arnoczky; Martin Guimond; Matthew P Strout; Lan Feng; Tatsuya Nakamura; Li Yu; Laura J Rush; Michael Weinstein; Gustavo Leone; Lizhao Wu; Amy K Ferketich; Susan P Whitman; Guido Marcucci; Michael A Caligiuri
Mll partial tandem duplication induces aberrant Hox expression in vivo via specific epigenetic alterations.
The Journal of clinical investigation 2006;116(10):2707-16.
2005: Nicola Logan; Anne Graham; Xuijie Zhao; Rebecca Fisher; Baidehi Maiti; Gustavo Leone; Nicholas B La Thangue
E2F-8: an E2F family member with a similar organization of DNA-binding domains to E2F-7.
Oncogene 2005;24(31):5000-4.
2005: Baidehi Maiti; Jing Li; Alain de Bruin; Faye Martin; Cynthia Timmers; Rene Opavsky; Kaustubha Patil; John Tuttle; Whitney Cleghorn; Gustavo Leone
Cloning and characterization of mouse E2F8, a novel mammalian E2F family member capable of blocking cellular proliferation.
The Journal of biological chemistry 2005;280(18):18211-20.
2004: Li Yu; Chunhui Liu; Kristi Bennett; Yue-Zhong Wu; Zunyan Dai; Jeffrey B VanDeusen; Rene Opavsky; Aparna Raval; Prashant Trikha; Ben Rodriguez; Brian Becknell; Charlene Mao; Stephen Lee; Ramana V Davuluri; Gustavo Leone; Ignatia B Van den Veyver; Michael A Caligiuri; Christoph Plass
A NotI-EcoRV promoter library for studies of genetic and epigenetic alterations in mouse models of human malignancies.
Genomics 2004;84(4):647-60.
2004: Yuying Jiang; Harold I Saavedra; Michael P Holloway; Gustavo Leone; Rachel A Altura
Aberrant regulation of survivin by the RB/E2F family of proteins.
The Journal of biological chemistry 2004;279(39):40511-20.
2003: Alain de Bruin; Baidehi Maiti; Laszlo Jakoi; Cynthia Timmers; Robin Buerki; Gustavo Leone
Identification and characterization of E2F7, a novel mammalian E2F family member capable of blocking cellular proliferation.
The Journal of biological chemistry 2003;278(43):42041-9.
2003: Alain de Bruin; Lizhao Wu; Harold I Saavedra; Pamela Wilson; Ying Yang; Thomas J Rosol; Michael Weinstein; Michael L Robinson; Gustavo Leone
Rb function in extraembryonic lineages suppresses apoptosis in the CNS of Rb-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(11):6546-51.
2003: Harold I Saavedra; Baidehi Maiti; Cynthia Timmers; Rachel A Altura; Yukari Tokuyama; Kenji Fukasawa; Gustavo Leone
Inactivation of E2F3 results in centrosome amplification.
Cancer cell 2003;3(4):333-46.
2003: Lizhao Wu; Alain de Bruin; Harold I Saavedra; Maja Starovic; Anthony Trimboli; Ying Yang; Jana Opavska; Pamela Wilson; John C Thompson; Michael C Ostrowski; Thomas J Rosol; Laura A Woollett; Michael Weinstein; James C Cross; Michael L Robinson; Gustavo Leone
Extra-embryonic function of Rb is essential for embryonic development and viability.
Nature 2003;421(6926):942-7.
2002: Aránzazu de la Puente; Julia Hall; Yue-Zhong Wu; Gustavo Leone; Jo Peters; Bong-June Yoon; Paul D Soloway; Christoph Plass
Structural characterization of Rasgrf1 and a novel linked imprinted locus.
Gene 2002;291(1-2):287-97.
2002: Harold I Saavedra; Lizhao Wu; Alain de Bruin; Cynthia Timmers; Thomas J Rosol; Michael Weinstein; Michael L Robinson; Gustavo Leone
Specificity of E2F1, E2F2, and E2F3 in mediating phenotypes induced by loss of Rb.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 2002;13(5):215-25.
2002: Jeanette Gowen Cook; Chi-Hyun Park; Thomas W Burke; Gustavo Leone; James DeGregori; Amber Engel; Joseph R Nevins
Analysis of Cdc6 function in the assembly of mammalian prereplication complexes.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(3):1347-52.
2001: Lizhao Wu; Cynthia Timmers; Baidehi Maiti; Harold I Saavedra; L Sang; G T Chong; F Nuckolls; Paloma H Giangrande; Fred A Wright; Seth J Field; Michael E Greenberg; Stuart H Orkin; Joseph R Nevins; Michael L Robinson; Gustavo Leone
The E2F1-3 transcription factors are essential for cellular proliferation.
Nature 2001;414(6862):457-62.
2001: Stephan M Tanner; J L Austin; Gustavo Leone; Laura J Rush; Christoph Plass; Kristiina Heinonen; Krzysztof Mrózek; H Sill; S Knuutila; Jonathan E Kolitz; Kellie J Archer; Michael A Caligiuri; Clara D Bloomfield; Albert de La Chapelle
BAALC, the human member of a novel mammalian neuroectoderm gene lineage, is implicated in hematopoiesis and acute leukemia.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(24):13901-6.
2001: Gustavo Leone; Rosalie C Pelz; Erich Huang; Rachel E Rempel; F Nuckolls; C H Park; Paloma H Giangrande; Lizhao Wu; Harold I Saavedra; Seth J Field; M A Thompson; H Yang; Y Fujiwara; Michael E Greenberg; Stuart H Orkin; Clay Smith; Joseph R Nevins
Myc requires distinct E2F activities to induce S phase and apoptosis.
Molecular cell 2001;8(1):105-13.
2001: Seiichi Ishida; Erich Huang; Harry Zuzan; Rainer Spang; Gustavo Leone; Mike West; Joseph R Nevins
Role for E2F in control of both DNA replication and mitotic functions as revealed from DNA microarray analysis.
Molecular and cellular biology 2001;21(14):4684-99.
2000: D S Smith; Gustavo Leone; James DeGregori; Mohamed Ahmed; Mazin B Qumsiyeh; Joseph R Nevins
Induction of DNA replication in adult rat neurons by deregulation of the retinoblastoma/E2F G1 cell cycle pathway.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 2000;11(12):625-33.
2000: M R Adams; Rosalie C Pelz; F Nuckolls; Gustavo Leone; Joseph R Nevins
Complex transcriptional regulatory mechanisms control expression of the E2F3 locus.
Molecular and cellular biology 2000;20(10):3633-9.
2000: Gustavo Leone; F Nuckolls; Seiichi Ishida; M Adams; Rosalie C Pelz; L Jakoi; alexander miron; Joseph R Nevins
Identification of a novel E2F3 product suggests a mechanism for determining specificity of repression by Rb proteins.
Molecular and cellular biology 2000;20(10):3626-32.
1999: Gustavo Leone; James DeGregori; L Jakoi; Jeanette Gowen Cook; Joseph R Nevins
Collaborative role of E2F transcriptional activity and G1 cyclindependent kinase activity in the induction of S phase.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(12):6626-31.
1999: Rosalie C Pelz; Gustavo Leone; James DeGregori; Joseph R Nevins
Ras enhances Myc protein stability.
Molecular cell 1999;3(2):169-79.
1998: Gustavo Leone; James DeGregori; Z Yan; L Jakoi; Seiichi Ishida; R Sanders Williams; Joseph R Nevins
E2F3 activity is regulated during the cell cycle and is required for the induction of S phase.
Genes & development 1998;12(14):2120-30.
1998: E J Smith; Gustavo Leone; Joseph R Nevins
Distinct mechanisms control the accumulation of the Rb-related p107 and p130 proteins during cell growth.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1998;9(4):297-303.
1998: Timothy F Kowalik; James DeGregori; Gustavo Leone; L Jakoi; Joseph R Nevins
E2F1-specific induction of apoptosis and p53 accumulation, which is blocked by Mdm2.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1998;9(2):113-8.
1997: Joseph R Nevins; Gustavo Leone; James DeGregori; L Jakoi
Role of the Rb/E2F pathway in cell growth control.
Journal of cellular physiology 1997;173(2):233-6.
1997: James DeGregori; Gustavo Leone; alexander miron; L Jakoi; Joseph R Nevins
Distinct roles for E2F proteins in cell growth control and apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(14):7245-50.
1997: Gustavo Leone; James DeGregori; Rosalie C Pelz; L Jakoi; Joseph R Nevins
Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F.
Nature 1997;387(6631):422-6.
1997: Joseph R Nevins; James DeGregori; L Jakoi; Gustavo Leone
Functional analysis of E2F transcription factor.
Methods in enzymology 1997;283():205-19.
1996: K Ohtani; James DeGregori; Gustavo Leone; D R Herendeen; Thomas J Kelly; Joseph R Nevins
Expression of the HsOrc1 gene, a human ORC1 homolog, is regulated by cell proliferation via the E2F transcription factor.
Molecular and cellular biology 1996;16(12):6977-84.
1996: E J Smith; Gustavo Leone; James DeGregori; L Jakoi; Joseph R Nevins
The accumulation of an E2F-p130 transcriptional repressor distinguishes a G0 cell state from a G1 cell state.
Molecular and cellular biology 1996;16(12):6965-76.
1995: James DeGregori; Gustavo Leone; K Ohtani; alexander miron; Joseph R Nevins
E2F-1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity.
Genes & development 1995;9(23):2873-87.