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Francesco Leonetti

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Chemicals & Drugs

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Publications

TOP 3
Angelo Danilo Favia; Francesco Leonetti; Orazio Nicolotti; Angela Stefanachi; Angelo Carotti
Computational methods for the design of potent aromatase inhibitors.
Marco Catto; Saverio Cellamare; Francesco Leonetti; Orazio Nicolotti; Paolo Pesce; leonardo pisani; Angela Stefanachi; Angelo Carotti
Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase.
Orazio Nicolotti; leonardo pisani; Angela Stefanachi; Paolo Tortorella; Marco Catto; Saverio Cellamare; Ilenia Giangreco; Francesco Leonetti; Fulvio Loiodice; Maria Barletta; Angelo Carotti
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9.

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All Publications

2013: Angelo Danilo Favia; Francesco Leonetti; Orazio Nicolotti; Angela Stefanachi; Angelo Carotti
Computational methods for the design of potent aromatase inhibitors.
Expert opinion on drug discovery 2013;8(4):395-409.
2013: Marco Catto; Saverio Cellamare; Francesco Leonetti; Orazio Nicolotti; Paolo Pesce; leonardo pisani; Angela Stefanachi; Angelo Carotti
Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase.
Bioorganic & medicinal chemistry 2013;21(1):146-52.
2012: Orazio Nicolotti; leonardo pisani; Angela Stefanachi; Paolo Tortorella; Marco Catto; Saverio Cellamare; Ilenia Giangreco; Francesco Leonetti; Fulvio Loiodice; Maria Barletta; Angelo Carotti
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9.
European journal of medicinal chemistry 2012;58():368-76.
2011: Orazio Nicolotti; Angela Stefanachi; Ilenia Giangreco; Antonellina Introcaso; Francesco Leonetti; Angelo Carotti
Strategies of multi-objective optimization in drug discovery and development.
Expert opinion on drug discovery 2011;6(9):871-84.
2011: Ilenia Giangreco; Antonio Laghezza; Gianluca Lattanzi; Francesco Leonetti; Orazio Nicolotti; Angela Stefanachi; Marco Catto; Angelo Carotti
Insights into the complex formed by matrix metalloproteinase-2 and alloxan inhibitors: molecular dynamics simulations and free energy calculations.
PloS one 2011;6(10):e25597.
2011: leonardo pisani; Angela Stefanachi; F Campagna; Marco Catto; Francesco Leonetti; Orazio Nicolotti; Angelo Carotti
Targeting monoamine oxidases with multipotent ligands: an emerging strategy in the search of new drugs against neurodegenerative diseases.
Current medicinal chemistry 2011;18(30):4568-87.
2010: leonardo pisani; Marco Catto; Ilenia Giangreco; Francesco Leonetti; Orazio Nicolotti; Angela Stefanachi; Saverio Cellamare; Angelo Carotti
Design, synthesis, and biological evaluation of coumarin derivatives tethered to an edrophonium-like fragment as highly potent and selective dual binding site acetylcholinesterase inhibitors.
ChemMedChem 2010;5(9):1616-30.
2010: Orazio Nicolotti; Ilenia Giangreco; Teresa Fabiola Miscioscia; Marino Convertino; Francesco Leonetti; leonardo pisani; Angelo Carotti
Screening of benzamidine-based thrombin inhibitors via a linear interaction energy in continuum electrostatics model.
Journal of computer-aided molecular design 2010;24(2):117-29.
2009: leonardo pisani; Giovanni Muncipinto; Teresa Fabiola Miscioscia; Orazio Nicolotti; Francesco Leonetti; Marco Catto; Carla Caccia; Patricia Salvati; Ramon Soto-Otero; Estefania Mendez-Alvarez; Celine Passeleu; Angelo Carotti
Discovery of a novel class of potent coumarin monoamine oxidase B inhibitors: development and biopharmacological profiling of 7-[(3-chlorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one methanesulfonate (NW-1772) as a highly potent, selective, reversible, and orally active monoamine oxidase B inhibitor.
Journal of medicinal chemistry 2009;52(21):6685-706.
2008: Angela Stefanachi; Orazio Nicolotti; Francesco Leonetti; Saverio Cellamare; Francesco Campagna; Maria Isabel Loza; Jose Manuel Brea; Fernando Mazza; Enrico Gavuzzo; Angelo Carotti
1,3-Dialkyl-8-(hetero)aryl-9-OH-9-deazaxanthines as potent A2B adenosine receptor antagonists: design, synthesis, structure-affinity and structure-selectivity relationships.
Bioorganic & medicinal chemistry 2008;16(22):9780-9.
2008: Francesco Leonetti; Marco Catto; Orazio Nicolotti; leonardo pisani; Anna Cappa; Angela Stefanachi; Angelo Carotti
Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors.
Bioorganic & medicinal chemistry 2008;16(15):7450-6.
2008: Orazio Nicolotti; Teresa Fabiola Miscioscia; Angelo Carotti; Francesco Leonetti; Angelo Carotti
An integrated approach to ligand- and structure-based drug design: development and application to a series of serine protease inhibitors.
Journal of chemical information and modeling 2008;48(6):1211-26.
2007: Orazio Nicolotti; Teresa Fabiola Miscioscia; Francesco Leonetti; Giovanni Muncipinto; Angelo Carotti
Screening of matrix metalloproteinases available from the protein data bank: insights into biological functions, domain organization, and zinc binding groups.
Journal of chemical information and modeling 2007;47(6):2439-48.
2007: Angelo Carotti; Marco Catto; Francesco Leonetti; Francesco Campagna; Ramón Soto-Otero; Estefanía Méndez-Alvarez; Ulrike Thull; Bernard Testa; Cosimo Altomare
Synthesis and monoamine oxidase inhibitory activity of new pyridazine-, pyrimidine- and 1,2,4-triazine-containing tricyclic derivatives.
Journal of medicinal chemistry 2007;50(22):5364-71.
2007: Francesco Leonetti; Carmelida Capaldi; leonardo pisani; Orazio Nicolotti; Giovanni Muncipinto; Angela Stefanachi; Saverio Cellamare; Carla Caccia; Angelo Carotti
Solid-phase synthesis and insights into structure-activity relationships of safinamide analogues as potent and selective inhibitors of type B monoamine oxidase.
Journal of medicinal chemistry 2007;50(20):4909-16.
2006: Laura Novaroli; Antoine Daina; Elisabeth Favre; Juan Bravo; Angelo Carotti; Francesco Leonetti; Marco Catto; Pierre-Alain Carrupt; Marianne Reist
Impact of species-dependent differences on screening, design, and development of MAO B inhibitors.
Journal of medicinal chemistry 2006;49(21):6264-72.
2006: Marco Catto; Orazio Nicolotti; Francesco Leonetti; Angelo Carotti; Angelo Danilo Favia; Ramón Soto-Otero; Estefanía Méndez-Alvarez; Angelo Carotti
Structural insights into monoamine oxidase inhibitory potency and selectivity of 7-substituted coumarins from ligand- and target-based approaches.
Journal of medicinal chemistry 2006;49(16):4912-25.
2004: Francesco Leonetti; Angelo Danilo Favia; Angela Rao; Rosaria Aliano; Anja Paluszcak; Rolf W Hartmann; Angelo Carotti
Design, synthesis, and 3D QSAR of novel potent and selective aromatase inhibitors.
Journal of medicinal chemistry 2004;47(27):6792-803.
2001: Corinne Brühlmann; Fred Ooms; Pierre-Alain Carrupt; Bernard Testa; Marco Catto; Francesco Leonetti; Cosimo Altomare; Angelo Carotti
Coumarins derivatives as dual inhibitors of acetylcholinesterase and monoamine oxidase.
Journal of medicinal chemistry 2001;44(19):3195-8.
2000: Carmela Gnerre; Marco Catto; Francesco Leonetti; P Weber; Pierre-Alain Carrupt; Cosimo Altomare; Angelo Carotti; Bernard Testa
Inhibition of monoamine oxidases by functionalized coumarin derivatives: biological activities, QSARs, and 3D-QSARs.
Journal of medicinal chemistry 2000;43(25):4747-58.