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John Leong

Research Profile

Physiology

Bacterial Adhesions

Chemicals & Drugs

Living Beings

Disorders

Genes & Molecular Sequences

Amino Acid Sequences

Phenomena

Protein Binding

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Publications

TOP 3
Vijay A K Rathinam; Anna Sokolovska; Lynda M Stuart; Sivapriya Kailasan Vanaja; Lisa Waggoner; Christine Becker; John M Leong; Katherine A Fitzgerald
TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.
Kenneth G Campellone; John M Leong; Anosha D Siripala; Matt D Welch
Membrane-deforming proteins play distinct roles in actin pedestal biogenesis by enterohemorrhagic Escherichia coli.
Emily M Mallick; Jean Mukherjee; Barbara J Sheppard; Saul Tzipori; Vijay K Vanguri; Michael J Brady; Arthur Donohue-Rolfe; John M Leong; Hui Liu; SA Luperchio; Loranne Magoun; David B Schauer
Allele- and tir-independent functions of intimin in diverse animal infection models.

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All Publications

2012: Vijay A K Rathinam; Anna Sokolovska; Lynda M Stuart; Sivapriya Kailasan Vanaja; Lisa Waggoner; Christine Becker; John M Leong; Katherine A Fitzgerald
TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.
Cell 2012;150(3):606-19.
2012: Kenneth G Campellone; John M Leong; Anosha D Siripala; Matt D Welch
Membrane-deforming proteins play distinct roles in actin pedestal biogenesis by enterohemorrhagic Escherichia coli.
The Journal of biological chemistry 2012;287(24):20613-24.
2012: Emily M Mallick; Jean Mukherjee; Barbara J Sheppard; Saul Tzipori; Vijay K Vanguri; Michael J Brady; Arthur Donohue-Rolfe; John M Leong; Hui Liu; SA Luperchio; Loranne Magoun; David B Schauer
Allele- and tir-independent functions of intimin in diverse animal infection models.
Frontiers in microbiology 2012;3():11.
2011: Jens C de Groot; Jan Faix; Dirk W Heinz; John M Leong; Cammie F Lesser; Claudia Quedenau; Joachim Reichelt; Kai Schlüter; Christine Standfuss-Gabisch; Konrad Büssow; Yvonne Carius; Didier Vingadassalom; Stefanie M Weiss; Theresia E B Stradal
Structural basis for complex formation between human IRSp53 and the translocated intimin receptor Tir of enterohemorrhagic E. coli.
Structure (London, England : 1993) 2011;19(9):1294-306.
2011: Vivian M Benoit; Joshua R Fischer; Yi-Pin Lin; Nikhat Parveen; John M Leong
Allelic variation of the Lyme disease spirochete adhesin DbpA influences spirochetal binding to decorin, dermatan sulfate, and mammalian cells.
Infection and immunity 2011;79(9):3501-9.
2011: Michael J Brady; Arthur Donohue-Rolfe; Hui Liu; Loranne Magoun; Jean Mukherjee; Kenan C Murphy; Padhma Radhakrishnan; Saul Tzipori; John M Leong
Enhanced Actin Pedestal Formation by Enterohemorrhagic Escherichia coli O157:H7 Adapted to the Mammalian Host.
Frontiers in microbiology 2011;2():226.
2011: Yushuan Lai; John M Leong; Kathleen Riley; Andrew Cai; Ira M Herman
Calpain mediates epithelial cell microvillar effacement by enterohemorrhagic Escherichia coli.
Frontiers in microbiology 2011;2():222.
2010: Hongqi Liu; Denise Fitzgerald; Bruno Gran; John M Leong; Kishore R Alugupalli
Induction of distinct neurologic disease manifestations during relapsing fever requires T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(10):5859-64.
2010: Vivian M Benoit; Annett Petrich; Kishore R Alugupalli; Robin Marty-Roix; Annette Moter; John M Leong; Victor Boyartchuk
Genetic control of the innate immune response to Borrelia hermsii influences the course of relapsing fever in inbred strains of mice.
Infection and immunity 2010;78(2):586-94.
2010: Didier Vingadassalom; Kenneth G Campellone; Michael J Brady; Brian Skehan; Scott Evans Battle; Douglas Robbins; Archana Kapoor; Gail Hecht; Scott B Snapper; John M Leong
Enterohemorrhagic E. coli requires N-WASP for efficient type III translocation but not for EspFU-mediated actin pedestal formation.
PLoS pathogens 2010;6(8):e1001056.
2009: Didier Vingadassalom; Arunas Kazlauskas; Brian Skehan; Hui-Chun Cheng; Loranne Magoun; Douglas Robbins; Michael K Rosen; Kalle Saksela; John M Leong
Insulin receptor tyrosine kinase substrate links the E. coli O157:H7 actin assembly effectors Tir and EspF(U) during pedestal formation.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(16):6754-9.
2009: Ning J Pan; Michael J Brady; John M Leong; Jon Goguen
Targeting type III secretion in Yersinia pestis.
Antimicrobial agents and chemotherapy 2009;53(2):385-92.
2008: Qiang Chen; Joshua R Fischer; Vivian M Benoit; Nicholas P Dufour; Philip Youderian; John M Leong
In vitro CpG methylation increases the transformation efficiency of Borrelia burgdorferi strains harboring the endogenous linear plasmid lp56.
Journal of bacteriology 2008;190(24):7885-91.
2007: Michael J Brady; Kenneth G Campellone; Megha Ghildiyal; John M Leong
Enterohaemorrhagic and enteropathogenic Escherichia coli Tir proteins trigger a common Nck-independent actin assembly pathway.
Cellular microbiology 2007;9(9):2242-53.
2007: Pamela J Savage; Kenneth G Campellone; John M Leong
Interaction of enterohemorrhagic Escherichia coli (EHEC) with mammalian cells: cell adhesion, type III secretion, and actin pedestal formation.
Current protocols in microbiology 2007;Chapter 5():Unit 5A.1.
2007: Kishore R Alugupalli; Shizuo Akira; Egil Lien; John M Leong
MyD88- and Bruton's tyrosine kinase-mediated signals are essential for T cell-independent pathogen-specific IgM responses.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(6):3740-9.
2007: Kenneth G Campellone; Andrew J Roe; Anders Løbner-Olesen; Kenan C Murphy; Loranne Magoun; Michael J Brady; Arthur Donohue-Rolfe; Saul Tzipori; David L Gally; John M Leong; Martin G Marinus
Increased adherence and actin pedestal formation by dam-deficient enterohaemorrhagic Escherichia coli O157:H7.
Molecular microbiology 2007;63(5):1468-81.
2006: Kenneth G Campellone; Michael J Brady; Judith G Alamares; Daniel Rowe; Brian M Skehan; Donald J Tipper; John M Leong
Enterohaemorrhagic Escherichia coli Tir requires a C-terminal 12-residue peptide to initiate EspF-mediated actin assembly and harbours N-terminal sequences that influence pedestal length.
Cellular microbiology 2006;8(9):1488-503.
2006: Nikhat Parveen; Ken Cornell; James L Bono; Christen Chamberland; Patricia Rosa; John M Leong
Bgp, a secreted glycosaminoglycan-binding protein of Borrelia burgdorferi strain N40, displays nucleosidase activity and is not essential for infection of immunodeficient mice.
Infection and immunity 2006;74(5):3016-20.
2006: Richard Hayward; John M Leong; Vassilis Koronakis; Kenneth G Campellone
Exploiting pathogenic Escherichia coli to model transmembrane receptor signalling.
Nature reviews. Microbiology 2006;4(5):358-70.
2006: Joshua R Fischer; Kimberly T LeBlanc; John M Leong
Fibronectin binding protein BBK32 of the Lyme disease spirochete promotes bacterial attachment to glycosaminoglycans.
Infection and immunity 2006;74(1):435-41.
2005: Jenifer Coburn; Joshua R Fischer; John M Leong
Solving a sticky problem: new genetic approaches to host cell adhesion by the Lyme disease spirochete.
Molecular microbiology 2005;57(5):1182-95.
2005: Cyril Guyard; Earl M Chester; Sandra J Raffel; Merry E Schrumpf; Paul F Policastro; Stephen F Porcella; John M Leong; Tom G Schwan
Relapsing fever spirochetes contain chromosomal genes with unique direct tandemly repeated sequences.
Infection and immunity 2005;73(5):3025-37.
2005: Kenneth G Campellone; John M Leong
Nck-independent actin assembly is mediated by two phosphorylated tyrosines within enteropathogenic Escherichia coli Tir.
Molecular microbiology 2005;56(2):416-32.
2004: Kishore R Alugupalli; John M Leong; Robert T Woodland; Masamichi Muramatsu; Tasuku Honjo; Rachel M Gerstein
B1b lymphocytes confer T cell-independent long-lasting immunity.
Immunity 2004;21(3):379-90.
2004: Kenneth G Campellone; Douglas Robbins; John M Leong
EspFU is a translocated EHEC effector that interacts with Tir and N-WASP and promotes Nck-independent actin assembly.
Developmental cell 2004;7(2):217-28.
2004: Kenneth G Campellone; Susannah Rankin; Tony Pawson; Marc W Kirschner; Donald J Tipper; John M Leong
Clustering of Nck by a 12-residue Tir phosphopeptide is sufficient to trigger localized actin assembly.
The Journal of cell biology 2004;164(3):407-16.
2004: Thierry Touzé; Richard Hayward; Jeyanthy Eswaran; John M Leong; Vassilis Koronakis
Self-association of EPEC intimin mediated by the beta-barrel-containing anchor domain: a role in clustering of the Tir receptor.
Molecular microbiology 2004;51(1):73-87.
2003: Kishore R Alugupalli; Alan D Michelson; Isabelle Joris; Tom G Schwan; Kairbaan M Hodivala-Dilke; Richard O Hynes; John M Leong
Spirochete-platelet attachment and thrombocytopenia in murine relapsing fever borreliosis.
Blood 2003;102(8):2843-50.
2003: Joshua R Fischer; Nikhat Parveen; Loranne Magoun; John M Leong
Decorin-binding proteins A and B confer distinct mammalian cell type-specific attachment by Borrelia burgdorferi, the Lyme disease spirochete.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(12):7307-12.
2003: Kishore R Alugupalli; Rachel M Gerstein; Jianzhu Chen; Eva Szomolanyi-Tsuda; Robert T Woodland; John M Leong
The resolution of relapsing fever borreliosis requires IgM and is concurrent with expansion of B1b lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(7):3819-27.
2003: Nikhat Parveen; Melissa J Caimano; Justin D Radolf; John M Leong
Adaptation of the Lyme disease spirochaete to the mammalian host environment results in enhanced glycosaminoglycan and host cell binding.
Molecular microbiology 2003;47(5):1433-44.
2003: Kenneth G Campellone; John M Leong
Tails of two Tirs: actin pedestal formation by enteropathogenic E. coli and enterohemorrhagic E. coli O157:H7.
Current opinion in microbiology 2003;6(1):82-90.
2002: Benfang Lei; Frank R DeLeo; Sean D Reid; Jovanka M Voyich; Loranne Magoun; Mengyao Liu; Kevin R Braughton; Stacy M Ricklefs; Nancy P Hoe; Robert L Cole; John M Leong; James M Musser
Opsonophagocytosis-inhibiting mac protein of group a streptococcus: identification and characteristics of two genetic complexes.
Infection and immunity 2002;70(12):6880-90.
2002: Hui Liu; Padhma Radhakrishnan; Loranne Magoun; Moses Prabu; Kenneth G Campellone; Pamela Savage; Feng He; Celia A Schiffer; John M Leong
Point mutants of EHEC intimin that diminish Tir recognition and actin pedestal formation highlight a putative Tir binding pocket.
Molecular microbiology 2002;45(6):1557-73.
2002: Kenneth G Campellone; Andrew Giese; Donald J Tipper; John M Leong
A tyrosine-phosphorylated 12-amino-acid sequence of enteropathogenic Escherichia coli Tir binds the host adaptor protein Nck and is required for Nck localization to actin pedestals.
Molecular microbiology 2002;43(5):1227-41.
2002: John M Leong; Nikhat Parveen; Jon D Goguen
New approaches and old problems in the shadow of bioterrorism.
Trends in microbiology 2002;10(3):112-4.
2001: Kishore R Alugupalli; Alan D Michelson; Marc R Barnard; John M Leong
Serial determinations of platelet counts in mice by flow cytometry.
Thrombosis and haemostasis 2001;86(2):668-71.
2001: Kishore R Alugupalli; Alan D Michelson; Marc R Barnard; Douglas Robbins; Jenifer Coburn; E K Baker; M H Ginsberg; Tom G Schwan; John M Leong
Platelet activation by a relapsing fever spirochaete results in enhanced bacterium-platelet interaction via integrin alphaIIbbeta3 activation.
Molecular microbiology 2001;39(2):330-40.
2000: Jenifer Coburn; John M Leong
Microbiology. Arresting features of bacterial toxins.
Science (New York, N.Y.) 2000;290(5490):287-8.
2000: Loranne Magoun; Wolfram R Zückert; Douglas Robbins; Nikhat Parveen; Kishore R Alugupalli; Tom G Schwan; Alan G Barbour; John M Leong
Variable small protein (Vsp)-dependent and Vsp-independent pathways for glycosaminoglycan recognition by relapsing fever spirochaetes.
Molecular microbiology 2000;36(4):886-97.
2000: Nikhat Parveen; John M Leong
Identification of a candidate glycosaminoglycan-binding adhesin of the Lyme disease spirochete Borrelia burgdorferi.
Molecular microbiology 2000;35(5):1220-34.
1999: Jenifer Coburn; W Chege; Loranne Magoun; SC Bodary; John M Leong
Characterization of a candidate Borrelia burgdorferi beta3-chain integrin ligand identified using a phage display library.
Molecular microbiology 1999;34(5):926-40.
1999: Hui Liu; Loranne Magoun; SA Luperchio; D B Schauer; John M Leong
The Tir-binding region of enterohaemorrhagic Escherichia coli intimin is sufficient to trigger actin condensation after bacterial-induced host cell signalling.
Molecular microbiology 1999;34(1):67-81.
1999: Hui Liu; Loranne Magoun; John M Leong
beta1-chain integrins are not essential for intimin-mediated host cell attachment and enteropathogenic Escherichia coli-induced actin condensation.
Infection and immunity 1999;67(4):2045-9.
1999: Nikhat Parveen; Douglas Robbins; John M Leong
Strain variation in glycosaminoglycan recognition influences cell-type-specific binding by lyme disease spirochetes.
Infection and immunity 1999;67(4):1743-9.
1999: KE Stockbauer; Loranne Magoun; Mengyao Liu; E H Burns; S Gubba; S Renish; Xi Pan; SC Bodary; E Baker; Jenifer Coburn; John M Leong; James M Musser
A natural variant of the cysteine protease virulence factor of group A Streptococcus with an arginine-glycine-aspartic acid (RGD) motif preferentially binds human integrins alphavbeta3 and alphaIIbbeta3.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(1):242-7.
1998: John M Leong; Douglas Robbins; L Rosenfeld; B Lahiri; Nikhat Parveen
Structural requirements for glycosaminoglycan recognition by the Lyme disease spirochete, Borrelia burgdorferi.
Infection and immunity 1998;66(12):6045-8.
1998: Jenifer Coburn; Loranne Magoun; SC Bodary; John M Leong
Integrins alpha(v)beta3 and alpha5beta1 mediate attachment of lyme disease spirochetes to human cells.
Infection and immunity 1998;66(5):1946-52.
1998: John M Leong; H Wang; Loranne Magoun; J A Field; P E Morrissey; Douglas Robbins; J B Tatro; Jenifer Coburn; Nikhat Parveen
Different classes of proteoglycans contribute to the attachment of Borrelia burgdorferi to cultured endothelial and brain cells.
Infection and immunity 1998;66(3):994-9.
1995: John M Leong; P E Morrissey; E Ortega-Barria; M E Pereira; Jenifer Coburn
Hemagglutination and proteoglycan binding by the Lyme disease spirochete, Borrelia burgdorferi.
Infection and immunity 1995;63(3):874-83.
1995: John M Leong; P E Morrissey; A Marra; Ralph R Isberg
An aspartate residue of the Yersinia pseudotuberculosis invasin protein that is critical for integrin binding.
The EMBO journal 1995;14(3):422-31.
1994: Jenifer Coburn; Stephen W Barthold; John M Leong
Diverse Lyme disease spirochetes bind integrin alpha IIb beta 3 on human platelets.
Infection and immunity 1994;62(12):5559-67.
1993: John M Leong; P E Morrissey; Ralph R Isberg
A 76-amino acid disulfide loop in the Yersinia pseudotuberculosis invasin protein is required for integrin receptor recognition.
The Journal of biological chemistry 1993;268(27):20524-32.
1993: Jenifer Coburn; John M Leong; J K Erban
Integrin alpha IIb beta 3 mediates binding of the Lyme disease agent Borrelia burgdorferi to human platelets.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(15):7059-63.
1992: S Rankin; Ralph R Isberg; John M Leong
The integrin-binding domain of invasin is sufficient to allow bacterial entry into mammalian cells.
Infection and immunity 1992;60(9):3909-12.
1992: John M Leong; L Moitoso de Vargas; Ralph R Isberg
Binding of cultured mammalian cells to immobilized bacteria.
Infection and immunity 1992;60(2):683-6.
1991: John M Leong; R S Fournier; Ralph R Isberg
Mapping and topographic localization of epitopes of the Yersinia pseudotuberculosis invasin protein.
Infection and immunity 1991;59(10):3424-33.
1990: John M Leong; R S Fournier; Ralph R Isberg
Identification of the integrin binding domain of the Yersinia pseudotuberculosis invasin protein.
The EMBO journal 1990;9(6):1979-89.
1990: Ralph R Isberg; John M Leong
Multiple beta 1 chain integrins are receptors for invasin, a protein that promotes bacterial penetration into mammalian cells.
Cell 1990;60(5):861-71.
1988: Ralph R Isberg; John M Leong
Cultured mammalian cells attach to the invasin protein of Yersinia pseudotuberculosis.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(18):6682-6.