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Philip Leopold

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Maija Kiuru; Chisa Hidaka; Ralf-Harto Hubner; Jason Solomon; Anja Krause; Philip L Leopold; Helen-Ann Brown Epstein
Sonic hedgehog expands diaphyseal trabecular bone altering bone marrow niche and lymphocyte compartment.
Hiroki Saitoh; Philip L Leopold; Ben-Gary Harvey; Timothy P O'Connor; Stefan Worgall; Neil R Hackett; Ronald G Crystal
Emphysema mediated by lung overexpression of ADAM10.
Philip L Leopold; Michael J O'Mahony; X Julie Lian; Ann E Tilley; Ben-Gary Harvey; Helen-Ann Brown Epstein
Smoking is associated with shortened airway cilia.

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2009: Maija Kiuru; Chisa Hidaka; Ralf-Harto Hubner; Jason Solomon; Anja Krause; Philip L Leopold; Helen-Ann Brown Epstein
Sonic hedgehog expands diaphyseal trabecular bone altering bone marrow niche and lymphocyte compartment.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(8):1442-52.
2009: Hiroki Saitoh; Philip L Leopold; Ben-Gary Harvey; Timothy P O'Connor; Stefan Worgall; Neil R Hackett; Ronald G Crystal
Emphysema mediated by lung overexpression of ADAM10.
Clinical and translational science 2009;2(1):50-6.
2009: Philip L Leopold; Michael J O'Mahony; X Julie Lian; Ann E Tilley; Ben-Gary Harvey; Helen-Ann Brown Epstein
Smoking is associated with shortened airway cilia.
PloS one 2009;4(12):e8157.
2007: Philip L Leopold; Helen-Ann Brown Epstein
Intracellular trafficking of adenovirus: many means to many ends.
Advanced drug delivery reviews 2007;59(8):810-21.
2007: Yael Strulovici; Philip L Leopold; Timothy P O'Connor; Robert Pergolizzi; Helen-Ann Brown Epstein
Human embryonic stem cells and gene therapy.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(5):850-66.
2007: Adriana Heguy; Ben-Gary Harvey; Philip L Leopold; Igor Dolgalev; Tina Raman; Helen-Ann Brown Epstein
Responses of the human airway epithelium transcriptome to in vivo injury.
Physiological genomics 2007;29(2):139-48.
2007: Ben-Gary Harvey; Adriana Heguy; Philip L Leopold; Brendan J Carolan; Barbara Ferris; Helen-Ann Brown Epstein
Modification of gene expression of the small airway epithelium in response to cigarette smoking.
Journal of molecular medicine (Berlin, Germany) 2007;85(1):39-53.
2006: Brendan J Carolan; Adriana Heguy; Ben-Gary Harvey; Philip L Leopold; Barbara Ferris; Helen-Ann Brown Epstein
Up-regulation of expression of the ubiquitin carboxyl-terminal hydrolase L1 gene in human airway epithelium of cigarette smokers.
Cancer research 2006;66(22):10729-40.
2006: Philip L Leopold; Rebecca L Wendland; Theresa Vincent; Helen-Ann Brown Epstein
Neutralized adenovirus-immune complexes can mediate effective gene transfer via an Fc receptor-dependent infection pathway.
Journal of virology 2006;80(20):10237-47.
2006: Samir Kelkar; Bishnu P De; Guangping Gao; James M Wilson; Helen-Ann Brown Epstein; Philip L Leopold
A common mechanism for cytoplasmic dynein-dependent microtubule binding shared among adeno-associated virus and adenovirus serotypes.
Journal of virology 2006;80(15):7781-5.
2006: Robert Pergolizzi; Guangchun Jin; Diane Chan; Lorraine Pierre; James Bussel; Barbara Ferris; Philip L Leopold; Helen-Ann Brown Epstein
Correction of a murine model of von Willebrand disease by gene transfer.
Blood 2006;108(3):862-9.
2006: Philip L Leopold; K Kevin Pfister
Viral strategies for intracellular trafficking: motors and microtubules.
Traffic (Copenhagen, Denmark) 2006;7(5):516-23.
2006: Bishnu P De; Adriana Heguy; Neil R Hackett; Barbara Ferris; Philip L Leopold; John Lee; Lorraine Pierre; Guangping Gao; James M Wilson; Helen-Ann Brown Epstein
High levels of persistent expression of alpha1-antitrypsin mediated by the nonhuman primate serotype rh.10 adeno-associated virus despite preexisting immunity to common human adeno-associated viruses.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;13(1):67-76.
2005: Dolan Sondhi; D A Peterson; E Lela Giannaris; C T Sanders; B S Mendez; B De; A B Rostkowski; Barbara C Blanchard; Kimberly B Bjugstad; John R Sladek; D Eugene Redmond; Philip L Leopold; Stephen M Kaminsky; Neil R Hackett; Helen-Ann Brown Epstein
AAV2-mediated CLN2 gene transfer to rodent and non-human primate brain results in long-term TPP-I expression compatible with therapy for LINCL.
Gene therapy 2005;12(22):1618-32.
2005: Howard Lou; Helen-Ann Brown Epstein; Philip L Leopold
Enhanced efficacy of cholesterol-minus sonic hedgehog in postnatal skin.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(3):575-8.
2004: Bishnu De; Adriana Heguy; Philip L Leopold; Nabil Wasif; Robert J Korst; Neil R Hackett; Helen-Ann Brown Epstein
Intrapleural administration of a serotype 5 adeno-associated virus coding for alpha1-antitrypsin mediates persistent, high lung and serum levels of alpha1-antitrypsin.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;10(6):1003-10.
2004: Samir A Kelkar; K Kevin Pfister; Helen-Ann Brown Epstein; Philip L Leopold
Cytoplasmic dynein mediates adenovirus binding to microtubules.
Journal of virology 2004;78(18):10122-32.
2004: Theresa Vincent; Ralf F Pettersson; Helen-Ann Brown Epstein; Philip L Leopold
Cytokine-mediated downregulation of coxsackievirus-adenovirus receptor in endothelial cells.
Journal of virology 2004;78(15):8047-58.
2004: Stefan Worgall; Annette Busch; Michael Rivara; David Bonnyay; Philip L Leopold; Robert Merritt; Neil R Hackett; Peter W Rovelink; Joseph T Bruder; Thomas J Wickham; Imre Kovesdi; Helen-Ann Brown Epstein
Modification to the capsid of the adenovirus vector that enhances dendritic cell infection and transgene-specific cellular immune responses.
Journal of virology 2004;78(5):2572-80.
2004: Paul Whitlock; Neil R Hackett; Philip L Leopold; Todd K Rosengart; Helen-Ann Brown Epstein
Adenovirus-mediated transfer of a minigene expressing multiple isoforms of VEGF is more effective at inducing angiogenesis than comparable vectors expressing individual VEGF cDNAs.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;9(1):67-75.
2003: Philip L Leopold
Cell physiology as a variable in gene transfer to endothelium.
Current atherosclerosis reports 2003;5(3):171-7.
2002: Ivan Bergstein; Philip L Leopold; Noboru Sato; Andrey Panteleyev; Angela M Christiano; Ronald Crystal
In vivo enhanced expression of patched dampens the sonic hedgehog pathway.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;6(2):258-64.
2002: Joshua Rice; Ruth I Connor; Stefan Worgall; John P Moore; Philip L Leopold; Robert J Kaner; Helen-Ann Brown Epstein
Inhibition of HIV-1 replication in alveolar macrophages by adenovirus gene transfer vectors.
American journal of respiratory cell and molecular biology 2002;27(2):214-9.
2002: Helen-Ann Brown Epstein; Ben-Gary Harvey; Juan P Wisnivesky; Kelley A O'Donoghue; Karen W Chu; Jaman Maroni; Jolene C Muscat; Allison L Pippo; Connie E Wright; Robert J Kaner; Philip L Leopold; Paul D Kessler; Henrik S Rasmussen; Todd K Rosengart; Charleen Hollmann
Analysis of risk factors for local delivery of low- and intermediate-dose adenovirus gene transfer vectors to individuals with a spectrum of comorbid conditions.
Human gene therapy 2002;13(1):65-100.
2001: Noboru Sato; Philip L Leopold; Helen-Ann Brown Epstein
Effect of adenovirus-mediated expression of Sonic hedgehog gene on hair regrowth in mice with chemotherapy-induced alopecia.
Journal of the National Cancer Institute 2001;93(24):1858-64.
2001: M A Seidman; S M Hogan; R L Wendland; Stefan Worgall; Helen-Ann Brown Epstein; Philip L Leopold
Variation in adenovirus receptor expression and adenovirus vector-mediated transgene expression at defined stages of the cell cycle.
Molecular therapy : the journal of the American Society of Gene Therapy 2001;4(1):13-21.
2001: Theresa Vincent; Ben-Gary Harvey; S M Hogan; C J Bailey; Helen-Ann Brown Epstein; Philip L Leopold
Rapid assessment of adenovirus serum neutralizing antibody titer based on quantitative, morphometric evaluation of capsid binding and intracellular trafficking: population analysis of adenovirus capsid association with cells is predictive of adenovirus infectivity.
Journal of virology 2001;75(3):1516-21.
2001: N Miyazawa; Helen-Ann Brown Epstein; Philip L Leopold
Adenovirus serotype 7 retention in a late endosomal compartment prior to cytosol escape is modulated by fiber protein.
Journal of virology 2001;75(3):1387-400.
2000: Philip L Leopold
Fluorescence methods reveal intracellular trafficking of gene transfer vectors: the light toward the end of the tunnel.
Molecular therapy : the journal of the American Society of Gene Therapy 2000;1(4):302-3.
2000: Stefan Worgall; T S Worgall; K Kostarelos; R Singh; Philip L Leopold; Neil R Hackett; Helen-Ann Brown Epstein
Free cholesterol enhances adenoviral vector gene transfer and expression in CAR-deficient cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2000;1(1):39-48.
2000: Philip L Leopold; Geri Kreitzer; N Miyazawa; S Rempel; K Kevin Pfister; Enrique Rodriguez-Boulan; Helen-Ann Brown Epstein
Dynein- and microtubule-mediated translocation of adenovirus serotype 5 occurs after endosomal lysis.
Human gene therapy 2000;11(1):151-65.
1999: Ben-Gary Harvey; Stefan Worgall; Scott Ely; Philip L Leopold; Helen-Ann Brown Epstein
Cellular immune responses of healthy individuals to intradermal administration of an E1-E3- adenovirus gene transfer vector.
Human gene therapy 1999;10(17):2823-37.
1999: P Bezdicek; Stefan Worgall; Imre Kovesdi; M K Kim; J G Park; Theresa Vincent; Philip L Leopold; Alan D Schreiber; Helen-Ann Brown Epstein
Enhanced liver uptake of opsonized red blood cells after in vivo transfer of FcgammaRIIA cDNA to the liver.
Blood 1999;94(10):3448-55.
1999: Ben-Gary Harvey; Philip L Leopold; Neil R Hackett; T M Grasso; P M Williams; A L Tucker; Robert J Kaner; Barbara Ferris; Igor Gonda; T D Sweeney; R Ramalingam; Imre Kovesdi; S Shak; Helen-Ann Brown Epstein
Airway epithelial CFTR mRNA expression in cystic fibrosis patients after repetitive administration of a recombinant adenovirus.
The Journal of clinical investigation 1999;104(9):1245-55.
1999: Noboru Sato; Philip L Leopold; Helen-Ann Brown Epstein
Induction of the hair growth phase in postnatal mice by localized transient expression of Sonic hedgehog.
The Journal of clinical investigation 1999;104(7):855-64.
1999: Juan P Wisnivesky; Philip L Leopold; Helen-Ann Brown Epstein
Specific binding of the adenovirus capsid to the nuclear envelope.
Human gene therapy 1999;10(13):2187-95.
1999: N Miyazawa; Philip L Leopold; Neil R Hackett; Barbara Ferris; Stefan Worgall; E Falck-Pedersen; Helen-Ann Brown Epstein
Fiber swap between adenovirus subgroups B and C alters intracellular trafficking of adenovirus gene transfer vectors.
Journal of virology 1999;73(7):6056-65.
1999: Robert J Kaner; Stefan Worgall; Philip L Leopold; E Stolze; E Milano; Chisa Hidaka; R Ramalingam; Neil R Hackett; R Singh; Jeffrey M Bergelson; RW Finberg; E Falck-Pedersen; Helen-Ann Brown Epstein
Modification of the genetic program of human alveolar macrophages by adenovirus vectors in vitro is feasible but inefficient, limited in part by the low level of expression of the coxsackie/adenovirus receptor.
American journal of respiratory cell and molecular biology 1999;20(3):361-70.
1999: Chisa Hidaka; E Milano; Philip L Leopold; Jeffrey M Bergelson; Neil R Hackett; RW Finberg; Thomas J Wickham; Imre Kovesdi; Peter W Roelvink; Helen-Ann Brown Epstein
CAR-dependent and CAR-independent pathways of adenovirus vector-mediated gene transfer and expression in human fibroblasts.
The Journal of clinical investigation 1999;103(4):579-87.
1999: Stefan Worgall; R Singh; Philip L Leopold; Robert J Kaner; Neil R Hackett; N Topf; Malcolm A S Moore; Helen-Ann Brown Epstein
Selective expansion of alveolar macrophages in vivo by adenovirus-mediated transfer of the murine granulocyte-macrophage colony-stimulating factor cDNA.
Blood 1999;93(2):655-66.
1998: Edward A Hirschowitz; S Leonard; W Song; Barbara Ferris; Philip L Leopold; Jonathan J Lewis; Wilbur B Bowne; S Wang; Alan N Houghton; Helen-Ann Brown Epstein
Adenovirus-mediated expression of melanoma antigen gp75 as immunotherapy for metastatic melanoma.
Gene therapy 1998;5(7):975-83.
1998: Philip L Leopold; Barbara Ferris; I Grinberg; Stefan Worgall; Neil R Hackett; Helen-Ann Brown Epstein
Fluorescent virions: dynamic tracking of the pathway of adenoviral gene transfer vectors in living cells.
Human gene therapy 1998;9(3):367-78.
1997: Stefan Worgall; Philip L Leopold; Gerhard Wolff; Barbara Ferris; N Van Roijen; Helen-Ann Brown Epstein
Role of alveolar macrophages in rapid elimination of adenovirus vectors administered to the epithelial surface of the respiratory tract.
Human gene therapy 1997;8(14):1675-84.