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Alain Lepape

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Julie Demaret; Tristan Ferry; Alain Lepape; Christophe Malcus; Francoise Poitevin-Later; Julien Saison; Fabienne Venet; Guillaume Monneret
Assessment of a novel flow cytometry technique of one-step intracellular staining: Example of FOXP3 in clinical samples.
Marie-Laurence Lambert; Alain Lepape; Eduardo Palencia Herrejon; Mercedes Palomar; Antonella Agodi; Stijn Blot; Michael Hiesmayr; Anne Ingenbleek; Uwe Frank
Prevention of ventilator-associated pneumonia in intensive care units: an international online survey.
Fabienne Venet; Nicolas Pasqual; Nadia Plantier; Françoise Poitevin-Later; Orchidée Filipe-Santos; Audrey Grives; Alain Lepape; Christophe Malcus; Guillaume Monneret
Decreased T-cell repertoire diversity in sepsis: a preliminary study.

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All Publications

2013: Julie Demaret; Tristan Ferry; Alain Lepape; Christophe Malcus; Francoise Poitevin-Later; Julien Saison; Fabienne Venet; Guillaume Monneret
Assessment of a novel flow cytometry technique of one-step intracellular staining: Example of FOXP3 in clinical samples.
Cytometry. Part B, Clinical cytometry 2013;84(3):187-93.
2013: Marie-Laurence Lambert; Alain Lepape; Eduardo Palencia Herrejon; Mercedes Palomar; Antonella Agodi; Stijn Blot; Michael Hiesmayr; Anne Ingenbleek; Uwe Frank
Prevention of ventilator-associated pneumonia in intensive care units: an international online survey.
Antimicrobial resistance and infection control 2013;2(1):9.
2013: Fabienne Venet; Nicolas Pasqual; Nadia Plantier; Françoise Poitevin-Later; Orchidée Filipe-Santos; Audrey Grives; Alain Lepape; Christophe Malcus; Guillaume Monneret
Decreased T-cell repertoire diversity in sepsis: a preliminary study.
Critical care medicine 2013;41(1):111-9.
2013: Julie Demaret; Marie-Christine Jacob; Alain Lepape; Jean-François Timsit; Fabienne Venet; Alexandre Walencik; Guillaume Monneret
Inter-laboratory assessment of flow cytometric monocyte HLA-DR expression in clinical samples.
Cytometry. Part B, Clinical cytometry 2013;84(1):59-62.
2012: Jean-François Timsit; Caroline Tournegros; Gilles Troche; Aurélien Vesin; Jean-Ralph Zahar; Olivier Mimoz; Bruno Mourvillier; Gaétan Plantefeve; Stéphane Ruckly; Carole Schwebel; Bertrand Souweine; Christophe Adrie; Serge Alfandari; Marion Antona; Xavier Arrault; Julien Bohe; Régis Bronchard; Emmanuel Canet; Maité Garrouste-Orgeas; Remy Gauzit; Alain Lepape; Jean-Christophe Lucet
Randomized controlled trial of chlorhexidine dressing and highly adhesive dressing for preventing catheter-related infections in critically ill adults.
American journal of respiratory and critical care medicine 2012;186(12):1272-8.
2012: Fabienne Venet; Astrid Villars-Méchin; Françoise Poitevin-Later; Anne-Perrine Foray; Alain Lepape; Christophe Malcus; Guillaume Monneret
IL-7 restores lymphocyte functions in septic patients.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(10):5073-81.
2012: Jean-François Timsit; AG Venier; Sandrine Boussat; frederic barbut; A Francais; P Jarno; Alain Lepape; François L'Hériteau; S Ruckly; Anne Savey
A multicentre analysis of catheter-related infection based on a hierarchical model.
Intensive care medicine 2012;38(10):1662-72.
2012: J Robert; J-P Stahl; E Varon; J-P Bedos; X Bertrand; J-P Bru; Remy Gauzit; Alain Lepape; Y Péan
Point prevalence survey of antibiotic use in French hospitals in 2009.
The Journal of antimicrobial chemotherapy 2012;67(4):1020-6.
2012: Caroline Guignant; Alain Lepape; Fabienne Venet; Nicolas Voirin; Guillaume Monneret
Persistent high level of circulating midregional-proadrenomedullin and increased risk of nosocomial infections after septic shock.
The journal of trauma and acute care surgery 2012;72(1):293-6.
2011: Fabienne Venet; Françoise Poitevin-Later; Julien Bancel; Rémi Gebeile; Caroline Guignant; Alain Lepape; Christophe Malcus; Guillaume Monneret
Assessment of plasmatic immunoglobulin G, A and M levels in septic shock patients.
International immunopharmacology 2011;11(12):2086-90.
2011: Mathieu Fontaine; Caroline Landelle; Audrey Larue; Guillaume Monneret; Bruno Mougin; Alexandre Pachot; Fabienne Venet; Caroline Allombert; Marie-Angélique Cazalis; Alain Lepape
Delayed increase of S100A9 messenger RNA predicts hospital-acquired infection after septic shock.
Critical care medicine 2011;39(12):2684-90.
2011: Fanny Turrel-Davin; Fabienne Venet; Cécile Monnin; Alexandre Pachot; Christine Alberti-Segui; Véronique Barbalat; Elisabeth Cerrato; Alain Lepape; Guillaume Monneret
mRNA-based approach to monitor recombinant gamma-interferon restoration of LPS-induced endotoxin tolerance.
Critical care (London, England) 2011;15(5):R252.
2011: Fabienne Venet; Alain Lepape; Guillaume Monneret
Clinical review: flow cytometry perspectives in the ICU - from diagnosis of infection to monitoring of injury-induced immune dysfunctions.
Critical care (London, England) 2011;15(5):231.
2011: Guillaume Monneret; Alain Lepape; Fabienne Venet
A dynamic view of mHLA-DR expression in management of severe septic patients.
Critical care (London, England) 2011;15(5):198.
2011: Philippe Vanhems; Nicolas Voirin; Bernard Allaouchiche; Laurent Argaud; François Artru; Thomas Bénet; Jean-Charles Cêtre; Dominique Chassard; Dominique Chassard; Gérard Fournier; Raphaëlle Girard; Claude Guérin; Pierre-Yves Gueugniaud; Didier Jacques; Jean-Marie Januel; Jean-Jacques Lehot; Alain Lepape; Marie-Hélène Metzger; Marie-Christine Nicolle; Marc-Olivier Robert; Jacqueline Grando
Early-onset ventilator-associated pneumonia incidence in intensive care units: a surveillance-based study.
BMC infectious diseases 2011;11():236.
2011: Caroline Guignant; Xin Huang; Hakim Kherouf; Alain Lepape; Christophe Malcus; Guillaume Monneret; Françoise Poitevin; Bernard Allaouchiche; Alfred Ayala; Aurélie Chéron; Laure Denis; François Gueyffier; Fabienne Venet
Programmed death-1 levels correlate with increased mortality, nosocomial infection and immune dysfunctions in septic shock patients.
Critical care (London, England) 2011;15(2):R99.
2011: Philippe Montravers; Benoît Veber; Jean-Pierre Bedos; Herve Dupont; Remy Gauzit; Alain Lepape
Strategies of initiation and streamlining of antibiotic therapy in 41 French intensive care units.
Critical care (London, England) 2011;15(1):R17.
2010: Caroline Guignant; Fabienne Venet; Nicolas Voirin; Françoise Poitevin; Christophe Malcus; Julien Bohé; Alain Lepape; Guillaume Monneret
Proatrial natriuretic peptide is a better predictor of 28-day mortality in septic shock patients than proendothelin-1.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2010;48(12):1813-20.
2010: Caroline Landelle; Alain Lepape; Nicolas Voirin; Eve Tognet; Fabienne Venet; Julien Bohé; Philippe Vanhems; Guillaume Monneret
Low monocyte human leukocyte antigen-DR is independently associated with nosocomial infections after septic shock.
Intensive care medicine 2010;36(11):1859-66.
2010: Pierre Kalfon; Olivier Mimoz; Pascal Auquier; Anderson Loundou; Rémy Gauzit; Alain Lepape; Jean Laurens; Bernard Garrigues; Thierry Pottecher; Yannick Mallédant
Development and validation of a questionnaire for quantitative assessment of perceived discomforts in critically ill patients.
Intensive care medicine 2010;36(10):1751-8.
2010: Fabienne Venet; Fanny Davin; Caroline Guignant; Audrey Larue; Marie-Angélique Cazalis; Romain Darbon; Caroline Allombert; Bruno Mougin; Christophe Malcus; Françoise Poitevin-Later; Alain Lepape; Guillaume Monneret
Early assessment of leukocyte alterations at diagnosis of septic shock.
Shock (Augusta, Ga.) 2010;34(4):358-63.
2010: Jean-Marie Januel; Stephan Harbarth; Robert Allard; Nicolas Voirin; Alain Lepape; Bernard Allaouchiche; Claude Guerin; Jean-Jacques Lehot; Marc-Olivier Robert; Gérard Fournier; Didier Jacques; Dominique Chassard; Pierre-Yves Gueugniaud; François Artru; Paul Petit; Dominique Robert; Ismaël Mohammedi; Raphaëlle Girard; Jean-Charles Cêtre; Marie-Christine Nicolle; Jacqueline Grando; Jacques Fabry; Philippe Vanhems
Estimating attributable mortality due to nosocomial infections acquired in intensive care units.
Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America 2010;31(4):388-94.
2010: Fanny Turrel-Davin; Caroline Guignant; Alain Lepape; Bruno Mougin; Guillaume Monneret; Fabienne Venet
Upregulation of the pro-apoptotic genes BID and FAS in septic shock patients.
Critical care (London, England) 2010;14(4):R133.
2009: Caroline Guignant; Nicolas Voirin; Fabienne Venet; Françoise Poitevin; Christophe Malcus; Julien Bohé; Alain Lepape; Guillaume Monneret
Assessment of pro-vasopressin and pro-adrenomedullin as predictors of 28-day mortality in septic shock patients.
Intensive care medicine 2009;35(11):1859-67.
2009: Xin Huang; Fabienne Venet; Yvonne L Wang; Alain Lepape; Zhenglong Yuan; Yaping Chen; Ryan Swan; Hakim Kherouf; Guillaume Monneret; Chun-Shiang Chung; Alfred Ayala
PD-1 expression by macrophages plays a pathologic role in altering microbial clearance and the innate inflammatory response to sepsis.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(15):6303-8.
2009: Philippe Montravers; Alain Lepape; Luc Dubreuil; Remy Gauzit; Yves Pean; Daniel Benchimol; Herve Dupont
Clinical and microbiological profiles of community-acquired and nosocomial intra-abdominal infections: results of the French prospective, observational EBIIA study.
The Journal of antimicrobial chemotherapy 2009;63(4):785-94.
2009: Fabienne Venet; Chun-Shiang Chung; Hakim Kherouf; Anne Geeraert; Chistophe Malcus; Françoise Poitevin; Julien Bohé; Alain Lepape; Alfred Ayala; Guillaume Monneret
Increased circulating regulatory T cells (CD4(+)CD25 (+)CD127 (-)) contribute to lymphocyte anergy in septic shock patients.
Intensive care medicine 2009;35(4):678-86.
2008: Caroline Landelle; Alain Lepape; Adrien Français; Eve Tognet; Hélène Thizy; Nicolas Voirin; Jean-François Timsit; Guillaume Monneret; Philippe Vanhems
Nosocomial infection after septic shock among intensive care unit patients.
Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America 2008;29(11):1054-65.
2008: Fanny Turrel; Caroline Guignant; Fabienne Venet; Alain Lepape; Guillaume Monneret
Innovative therapeutic strategies for restoring lymphocyte functions in septic patients.
Inflammation & allergy drug targets 2008;7(3):181-6.
2008: Alexandre Pachot; Marie-Angélique Cazalis; Fabienne Venet; Fanny Turrel; Caroline Faudot; Nicolas Voirin; Jennifer Diasparra; Naïck Bourgoin; Françoise Poitevin; Bruno Mougin; Alain Lepape; Guillaume Monneret
Decreased expression of the fractalkine receptor CX3CR1 on circulating monocytes as new feature of sepsis-induced immunosuppression.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(9):6421-9.
2008: Marine Giard; Alain Lepape; Bernard Allaouchiche; Claude Guerin; Jean-Jacques Lehot; Marc-Olivier Robert; Gérard Fournier; Didier Jacques; Dominique Chassard; Pierre-Yves Gueugniaud; François Artru; Paul Petit; Dominique Robert; Ismaël Mohammedi; Raphaëlle Girard; Jean-Charles Cêtre; Marie-Christine Nicolle; Jacqueline Grando; Jacques Fabry; Philippe Vanhems
Early- and late-onset ventilator-associated pneumonia acquired in the intensive care unit: comparison of risk factors.
Journal of critical care 2008;23(1):27-33.
2008: Philippe Vanhems; Dominique Baratin; Nicolas Voirin; Anne Savey; Emmanuelle Caillat-Vallet; Marie-Hélène Metzger; Alain Lepape
Reduction of urinary tract infections acquired in an intensive care unit during a 10-year surveillance program.
European journal of epidemiology 2008;23(9):641-5.
2008: Guillaume Monneret; Fabienne Venet; Alexandre Pachot; Alain Lepape
Monitoring immune dysfunctions in the septic patient: a new skin for the old ceremony.
Molecular medicine (Cambridge, Mass.) 2008;14(1-2):64-78.
2007: Guillaume Monneret; Nicolas Voirin; Irène Krawice-Radanne; Julien Bohé; Alain Lepape; Nathalie Rouas-Freiss; Edgardo D Carosella
Soluble human leukocyte antigen-G5 in septic shock: marked and persisting elevation as a predictor of survival.
Critical care medicine 2007;35(8):1942-7.
2007: C Suetens; Ingrid Morales; Anne Savey; M Palomar; M Hiesmayr; Alain Lepape; Petra Gastmeier; Jean-Claude Schmit; R Valinteliene; Jacques Fabry
European surveillance of ICU-acquired infections (HELICS-ICU): methods and main results.
The Journal of hospital infection 2007;65 Suppl 2():171-3.
2006: Fabienne Venet; Alexandre Pachot; Anne-Lise Debard; Julien Bohe; Jacques Bienvenu; Alain Lepape; William S Powell; Guillaume Monneret
Human CD4+CD25+ regulatory T lymphocytes inhibit lipopolysaccharide-induced monocyte survival through a Fas/Fas ligand-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(9):6540-7.
2006: Guillaume Monneret; Alain Lepape; Nicolas Voirin; Julien Bohé; Fabienne Venet; Anne-Lise Debard; Hélène Thizy; Jacques Bienvenu; François Gueyffier; Philippe Vanhems
Persisting low monocyte human leukocyte antigen-DR expression predicts mortality in septic shock.
Intensive care medicine 2006;32(8):1175-83.
2006: Alexandre Pachot; Alain Lepape; Sébastien Vey; Jacques Bienvenu; Bruno Mougin; Guillaume Monneret
Systemic transcriptional analysis in survivor and non-survivor septic shock patients: a preliminary study.
Immunology letters 2006;106(1):63-71.
2006: Claude Martin; C Brun-Buisson; Remy Gauzit; Alain Lepape; Yannick Malledant; D Payen; T Pottecher; Benoît Veber; Guy Bonmarchand; Jean Carlet; Jean Chastre; A Durocher; Jean-Yves Fagon; P Loirat; M-C Jars-Guincestre; Bernard Régnier; B Souweine
[Risk and control of nosocomial infection during resuscitation: statement of the Sfar/SRLF].
Annales françaises d'anesthèsie et de rèanimation 2006;25(1):117-23.
2005: Fabienne Venet; Julien Bohé; Anne-Lise Debard; Jacques Bienvenu; Alain Lepape; Guillaume Monneret
Both percentage of gammadelta T lymphocytes and CD3 expression are reduced during septic shock.
Critical care medicine 2005;33(12):2836-40.
2005: Alexandre Pachot; Guillaume Monneret; Aurélie Brion; Fabienne Venet; Julien Bohé; Jacques Bienvenu; Bruno Mougin; Alain Lepape
Messenger RNA expression of major histocompatibility complex class II genes in whole blood from septic shock patients.
Critical care medicine 2005;33(1):31-8; discussion 236-7.
2005: Alexandre Pachot; Guillaume Monneret; Nicolas Voirin; Philippe Leissner; Fabienne Venet; Julien Bohé; Didier Payen; Jacques Bienvenu; Bruno Mougin; Alain Lepape
Longitudinal study of cytokine and immune transcription factor mRNA expression in septic shock.
Clinical immunology (Orlando, Fla.) 2005;114(1):61-9.
2004: Fabienne Venet; Alain Lepape; Anne-Lise Debard; Jacques Bienvenu; Julien Bohé; Guillaume Monneret
The Th2 response as monitored by CRTH2 or CCR3 expression is severely decreased during septic shock.
Clinical immunology (Orlando, Fla.) 2004;113(3):278-84.
2004: Fabienne Venet; Alexandre Pachot; Anne-Lise Debard; Julien Bohé; Jacques Bienvenu; Alain Lepape; Guillaume Monneret
Increased percentage of CD4+CD25+ regulatory T cells during septic shock is due to the decrease of CD4+CD25- lymphocytes.
Critical care medicine 2004;32(11):2329-31.
2004: Guillaume Monneret; Marie-Emmanuelle Finck; Fabienne Venet; Anne-Lise Debard; Julien Bohé; Jacques Bienvenu; Alain Lepape
The anti-inflammatory response dominates after septic shock: association of low monocyte HLA-DR expression and high interleukin-10 concentration.
Immunology letters 2004;95(2):193-8.
2004: Pierrick Bedouch; José Labarère; Emmanuel Chirpaz; Benoît Allenet; Alain Lepape; Magali Fourny; Patricia Pavese; Pierre Girardet; Philippe Merloz; Dominique Saragaglia; jean calop; Patrice Francois
Compliance with guidelines on antibiotic prophylaxis in total hip replacement surgery: results of a retrospective study of 416 patients in a teaching hospital.
Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America 2004;25(4):302-7.
2004: Philippe Montravers; Annie Chalfine; Remy Gauzit; Alain Lepape; Jean Pierre Marmuse; Corinne Vouillot; Claude Martin
Clinical and therapeutic features of nonpostoperative nosocomial intra-abdominal infections.
Annals of surgery 2004;239(3):409-16.
2004: Remy Gauzit; Alain Lepape; Pierre Moine
[Nosocomial urinary tract infection].
Annales françaises d'anesthèsie et de rèanimation 2004;23(1):3-5.
2003: Danièle Klett; Serge Bernard; François Lecompte; Hervé Leroux; Thierry Magallon; Alain Locatelli; Alain Lepape; Yves Combarnous
Fast renal trapping of porcine luteinizing hormone (pLH) shown by 123I-scintigraphic imaging in rats explains its short circulatory half-life.
Reproductive biology and endocrinology : RB&E 2003;1():64.
2003: Elie Azoulay; Frédéric Pochard; Sylvie Chevret; Charles Arich; Francois Gilles BRIVET; Frédéric Brun; Pierre-Emmanuel Charles; Thibaut Desmettre; Didier Dubois; Richard Galliot; Maité Garrouste-Orgeas; Dany Goldgran-Toledano; Patrick Herbecq; Luc-Marie Joly; Mercé Jourdain; Michel Kaidomar; Alain Lepape; Nicolas Letellier; Olivier Marie; Bernard Page; Antoine Parrot; Pierre-Andre Rodie-Talbere; Alain Sermet; Alain Tenaillon; Marie Thuong; Patrick Tulasne; Jean-Roger Le Gall; Benoît Schlemmer
Family participation in care to the critically ill: opinions of families and staff.
Intensive care medicine 2003;29(9):1498-504.
2003: M-E Finck; N Elmenkouri; Anne-Lise Debard; Julien Bohé; Alain Lepape; Jacques Bienvenu; Guillaume Monneret
[Preliminary results in standardization of flow cytometry protocols for monocytic HLA-DR measurement and their application in the follow up of septic shock].
Annales de biologie clinique 2003;61(4):441-8.
2003: Guillaume Monneret; Anne-Lise Debard; Fabienne Venet; Julien Bohe; Olivier Hequet; Jacques Bienvenu; Alain Lepape
Marked elevation of human circulating CD4+CD25+ regulatory T cells in sepsis-induced immunoparalysis.
Critical care medicine 2003;31(7):2068-71.
2003: Guillaume Monneret; Maud Arpin; Fabienne Venet; Karim Maghni; Anne-Lise Debard; Alexandre Pachot; Alain Lepape; Jacques Bienvenu
Calcitonin gene related peptide and N-procalcitonin modulate CD11b upregulation in lipopolysaccharide activated monocytes and neutrophils.
Intensive care medicine 2003;29(6):923-8.
2003: Alain Lepape
[Epidemiology of Gram-positive infections in France: changing resistance].
Presse médicale (Paris, France : 1983) 2003;32(13 Pt 2):S5-8.
2003: Alain Lepape
Prevention of nosocomial infections in ICU. What is really effective?
Medicinski arhiv 2003;57(4 Suppl 1):15-8.
2002: Guillaume Monneret; Nadia Elmenkouri; Julien Bohe; Anne-Lise Debard; Marie-Claude Gutowski; Jacques Bienvenu; Alain Lepape
Analytical requirements for measuring monocytic human lymphocyte antigen DR by flow cytometry: application to the monitoring of patients with septic shock.
Clinical chemistry 2002;48(9):1589-92.
2001: Jean-Christophe Bouchut; Alain Lepape; P Y Carry
Effects of hydroxyethylstarch infusion on drug protein binding in critically ill patients.
European journal of anaesthesiology 2001;18(8):558-9.
2001: Jean-Christophe Bouchut; D Stamm; Olivier Boillot; Alain Lepape; Daniel Floret
Postoperative infectious complications in paediatric liver transplantation: a study of 48 transplants.
Paediatric anaesthesia 2001;11(1):93-8.
2000: Philippe Vanhems; Alain Lepape; Anne Savey; P Jambou; Jacques Fabry
Nosocomial pulmonary infection by antimicrobial-resistant bacteria of patients hospitalized in intensive care units: risk factors and survival.
The Journal of hospital infection 2000;45(2):98-106.
1998: Guillaume Monneret; C Doche; D V Durand; Alain Lepape; Jacques Bienvenu
Procalcitonin as a specific marker of bacterial infection in adults.
Clinical chemistry and laboratory medicine : CCLM / FESCC 1998;36(1):67-8.