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Ann Barbier

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Devin M Swanson; Chandra R Shah; Brian Lord; Kirsten Morton; Lisa K Dvorak; Curt Mazur; Richard Apodaca; Wei Xiao; Jamin D Boggs; Mark Feinstein; Sandy J Wilson; Ann J Barbier; Pascal Bonaventure; Timothy W Lovenberg; Nicholas I Carruthers
Heterocyclic replacement of the central phenyl core of diamine-based histamine H3 receptor antagonists.
Scott D Bembenek; John M Keith; Michael A Letavic; Richard Apodaca; Ann J Barbier; Lisa Dvorak; Leah Aluisio; Kirsten L Miller; Timothy W Lovenberg; Nicholas I Carruthers
Lead identification of acetylcholinesterase inhibitors-histamine H3 receptor antagonists from molecular modeling.
Kiev S Ly; Michael A Letavic; John M Keith; Jennifer M Miller; Emily M Stocking; Ann J Barbier; Pascal Bonaventure; Brian Lord; Xiaohui Jiang; Jamin D Boggs; Lisa Dvorak; Kirsten L Miller; Diane Nepomuceno; Sandy J Wilson; Nicholas I Carruthers
Synthesis and biological activity of piperazine and diazepane amides that are histamine H3 antagonists and serotonin reuptake inhibitors.

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All Publications

2009: Devin M Swanson; Chandra R Shah; Brian Lord; Kirsten Morton; Lisa K Dvorak; Curt Mazur; Richard Apodaca; Wei Xiao; Jamin D Boggs; Mark Feinstein; Sandy J Wilson; Ann J Barbier; Pascal Bonaventure; Timothy W Lovenberg; Nicholas I Carruthers
Heterocyclic replacement of the central phenyl core of diamine-based histamine H3 receptor antagonists.
European journal of medicinal chemistry 2009;44(11):4413-25.
2008: Scott D Bembenek; John M Keith; Michael A Letavic; Richard Apodaca; Ann J Barbier; Lisa Dvorak; Leah Aluisio; Kirsten L Miller; Timothy W Lovenberg; Nicholas I Carruthers
Lead identification of acetylcholinesterase inhibitors-histamine H3 receptor antagonists from molecular modeling.
Bioorganic & medicinal chemistry 2008;16(6):2968-73.
2008: Kiev S Ly; Michael A Letavic; John M Keith; Jennifer M Miller; Emily M Stocking; Ann J Barbier; Pascal Bonaventure; Brian Lord; Xiaohui Jiang; Jamin D Boggs; Lisa Dvorak; Kirsten L Miller; Diane Nepomuceno; Sandy J Wilson; Nicholas I Carruthers
Synthesis and biological activity of piperazine and diazepane amides that are histamine H3 antagonists and serotonin reuptake inhibitors.
Bioorganic & medicinal chemistry letters 2008;18(1):39-43.
2007: Ann J Barbier; Leah Aluisio; Brian Lord; Ying Qu; Sandy J Wilson; Jamin D Boggs; Pascal Bonaventure; Kirsten Miller; Ian Fraser; Lisa Dvorak; Cindy Pudiak; Christine Dugovic; Jonathan Shelton; Curt Mazur; Michael A Letavic; Nicholas I Carruthers; Timothy W Lovenberg
Pharmacological characterization of JNJ-28583867, a histamine H(3) receptor antagonist and serotonin reuptake inhibitor.
European journal of pharmacology 2007;576(1-3):43-54.
2007: John M Keith; Ann J Barbier; Sandy J Wilson; Kirstin Miller; Jamin D Boggs; Ian C Fraser; Curt Mazur; Timothy W Lovenberg; Nicholas I Carruthers
Dual serotonin transporter inhibitor/histamine H3 antagonists: development of rigidified H3 pharmacophores.
Bioorganic & medicinal chemistry letters 2007;17(19):5325-9.
2007: Michael A Letavic; Emily M Stocking; Ann J Barbier; Pascal Bonaventure; Jamin D Boggs; Brian Lord; Kirsten L Miller; Sandy J Wilson; Nicholas I Carruthers
Benzylamine histamine H(3) antagonists and serotonin reuptake inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(17):4799-803.
2007: John M Keith; Leslie A Gomez; Ann J Barbier; Sandy J Wilson; Jamin D Boggs; Brian Lord; Curt Mazur; Leah Aluisio; Timothy W Lovenberg; Nicholas I Carruthers
Pyrrolidino-tetrahydroisoquinolines bearing pendant heterocycles as potent dual H3 antagonist and serotonin transporter inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(15):4374-7.
2007: Emily M Stocking; Jennifer M Miller; Ann J Barbier; Sandy J Wilson; Jamin D Boggs; Heather M McAllister; Jiejun Wu; Timothy W Lovenberg; Nicholas I Carruthers; Ronald L Wolin
Synthesis and biological evaluation of diamine-based histamine H3 antagonists with serotonin reuptake inhibitor activity.
Bioorganic & medicinal chemistry letters 2007;17(11):3130-5.
2007: John M Keith; Leslie A Gomez; Ronald L Wolin; Ann J Barbier; Sandy J Wilson; Jamin D Boggs; Curt Mazur; Ian C Fraser; Brian Lord; Leah Aluisio; Timothy W Lovenberg; Nicholas I Carruthers
Pyrrolidino-tetrahydroisoquinolines as potent dual H3 antagonist and serotonin transporter inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(9):2603-7.
2007: Michael A Letavic; John M Keith; Kiev S Ly; Ann J Barbier; Jamin D Boggs; Sandy J Wilson; Brian Lord; Timothy W Lovenberg; Nicholas I Carruthers
Novel naphthyridines are histamine H3 antagonists and serotonin reuptake transporter inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(9):2566-9.
2007: Michael A Letavic; John M Keith; JIll Jablonowski; Emily M Stocking; Leslie A Gomez; Kiev S Ly; Jennifer M Miller; Ann J Barbier; Pascal Bonaventure; Jamin D Boggs; Sandy J Wilson; Kirsten L Miller; Brian Lord; Heather M McAllister; D J Tognarelli; Jiejun Wu; Marta C Abad; Carsten Schubert; Timothy W Lovenberg; Nicholas I Carruthers
Novel tetrahydroisoquinolines are histamine H3 antagonists and serotonin reuptake inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(4):1047-51.
2007: John M Keith; Leslie A Gomez; Michael A Letavic; Kiev S Ly; JIll Jablonowski; Mark Seierstad; Ann J Barbier; Sandy J Wilson; Jamin D Boggs; Ian C Fraser; Curt Mazur; Timothy W Lovenberg; Nicholas I Carruthers
Dual serotonin transporter/histamine H3 ligands: Optimization of the H3 pharmacophore.
Bioorganic & medicinal chemistry letters 2007;17(3):702-6.
2006: Anu J Airaksinen; JIll Jablonowski; Margaretha Van der Mey; Ann J Barbier; Rob P Klok; Joost Verbeek; Robert Schuit; J D M Herscheid; Josée E Leysen; Nicholas I Carruthers; Adriaan A Lammertsma; Albert D Windhorst
Radiosynthesis and biodistribution of a histamine H3 receptor antagonist 4-[3-(4-piperidin-1-yl-but-1-ynyl)-[11C]benzyl]-morpholine: evaluation of a potential PET ligand.
Nuclear medicine and biology 2006;33(6):801-10.
2006: Leon Chang; Lin Luo; James A Palmer; Steven Sutton; Sandy J Wilson; Ann J Barbier; J Guy Breitenbucher; Sandra R Chaplan; Michael Webb
Inhibition of fatty acid amide hydrolase produces analgesia by multiple mechanisms.
British journal of pharmacology 2006;148(1):102-13.
2006: Feiyong Jia; Motohisa Kato; Hongmei Dai; Ajing Xu; Tomohiro Okuda; Eiko Sakurai; Nobuyuki Okamura; Timothy W Lovenberg; Ann J Barbier; Nicholas I Carruthers; Kazuie Iinuma; Kazuhiko Yanai
Effects of histamine H(3) antagonists and donepezil on learning and mnemonic deficits induced by pentylenetetrazol kindling in weanling mice.
Neuropharmacology 2006;50(4):404-11.
2006: Devin M Swanson; Sandy J Wilson; Jamin D Boggs; Wei Xiao; Richard Apodaca; Ann J Barbier; Timothy W Lovenberg; Nicholas I Carruthers
Aplysamine-1 and related analogs as histamine H3 receptor antagonists.
Bioorganic & medicinal chemistry letters 2006;16(4):897-900.
2006: Michael A Letavic; Ann J Barbier; Curt A Dvorak; Nicholas I Carruthers
Recent medicinal chemistry of the histamine H3 receptor.
Progress in medicinal chemistry 2006;44():181-206.
2005: Curt A Dvorak; Richard Apodaca; Ann J Barbier; Craig W Berridge; Sandy J Wilson; Jamin D Boggs; Wei Xiao; Timothy W Lovenberg; Nicholas I Carruthers
4-phenoxypiperidines: potent, conformationally restricted, non-imidazole histamine H3 antagonists.
Journal of medicinal chemistry 2005;48(6):2229-38.
2004: Ann J Barbier; C Berridge; Christine Dugovic; Aaron D Laposky; Sandy J Wilson; Jamin D Boggs; Leah Aluisio; Brian Lord; Curt Mazur; Cindy Pudiak; Xavier Langlois; Wei Xiao; Richard Apodaca; Nicholas I Carruthers; Timothy W Lovenberg
Acute wake-promoting actions of JNJ-5207852, a novel, diamine-based H3 antagonist.
British journal of pharmacology 2004;143(5):649-61.
2003: Richard Apodaca; Curt A Dvorak; Wei Xiao; Ann J Barbier; Jamin D Boggs; Sandy J Wilson; Timothy W Lovenberg; Nicholas I Carruthers
A new class of diamine-based human histamine H3 receptor antagonists: 4-(aminoalkoxy)benzylamines.
Journal of medicinal chemistry 2003;46(18):3938-44.
2003: Sandy J Wilson; Timothy W Lovenberg; Ann J Barbier
A high-throughput-compatible assay for determining the activity of fatty acid amide hydrolase.
Analytical biochemistry 2003;318(2):270-5.
2002: Hiroshi Toyota; Christine Dugovic; Muriel Koehl; Aaron D Laposky; China Weber; Karen Ngo; Ying Wu; Doo H Lee; Kazuhiko Yanai; Eiko Sakurai; Takehiko Watanabe; Changlu Liu; Jingcai Chen; Ann J Barbier; Fred W Turek; Wai-Ping Fung-Leung; Timothy W Lovenberg
Behavioral characterization of mice lacking histamine H(3) receptors.
Molecular pharmacology 2002;62(2):389-97.