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Stephen Leppla

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Living Beings

Disorders

Anthrax

Concepts & Ideas

Molecular Sequence Data

Anatomy

Genes & Molecular Sequences

Amino Acid Sequence

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Co-Publications
Name
35
Moayeri, Mahtab
16
Klimpel, KR
12
Duesbery, Nicholas
12
Frankel, Arthur
9
Singh, Yogendra
9
Wiggins, Jason
8
Bugge, Thomas
7
Arora, N
7
Friedlander, Arthur
7
Li, Yan
7
Liu, Shihui
6
Little, Stephen
6
Liu, Shihui
6
Pomerantsev, Andrei
6
Eichacker, Peter

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Publications

TOP 3
Moayeri Mahtab; Leppla Stephen H
Cellular and systemic effects of anthrax lethal toxin and edema toxin.
Newman Zachary L; Leppla Stephen H; Moayeri Mahtab
CA-074Me protection against anthrax lethal toxin.
Chen Zhaochun; Moayeri Mahtab; Crown Devorah; Emerson Suzanne; Gorshkova Inna; Schuck Peter; Leppla Stephen H; Purcell Robert H
Novel chimpanzee/human monoclonal antibodies that neutralize anthrax lethal factor, and evidence for possible synergy with anti-protective antigen antibody.

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All Publications

2009: Moayeri Mahtab; Leppla Stephen H
Cellular and systemic effects of anthrax lethal toxin and edema toxin.
Molecular aspects of medicine 2009;30(6):439-55.
2009: Newman Zachary L; Leppla Stephen H; Moayeri Mahtab
CA-074Me protection against anthrax lethal toxin.
Infection and immunity 2009;77(10):4327-36.
2009: Chen Zhaochun; Moayeri Mahtab; Crown Devorah; Emerson Suzanne; Gorshkova Inna; Schuck Peter; Leppla Stephen H; Purcell Robert H
Novel chimpanzee/human monoclonal antibodies that neutralize anthrax lethal factor, and evidence for possible synergy with anti-protective antigen antibody.
Infection and immunity 2009;77(9):3902-8.
2009: Chen Zhaochun; Moayeri Mahtab; Zhao Huaying; Crown Devorah; Leppla Stephen H; Purcell Robert H
Potent neutralization of anthrax edema toxin by a humanized monoclonal antibody that competes with calmodulin for edema factor binding.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(32):13487-92.
2009: Pomerantsev Andrei P; Camp Andrew; Leppla Stephen H
A new minimal replicon of Bacillus anthracis plasmid pXO1.
Journal of bacteriology 2009;191(16):5134-46.
2009: Liu Shihui; Crown Devorah; Miller-Randolph Sharmina; Moayeri Mahtab; Wang Hailun; Hu Haijing; Morley Thomas; Leppla Stephen H
Capillary morphogenesis protein-2 is the major receptor mediating lethality of anthrax toxin in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(30):12424-9.
2009: Zhu Ping Jun; Hobson John P; Southall Noel; Qiu Cunping; Thomas Craig J; Lu Jiamo; Inglese James; Zheng Wei; Leppla Stephen H; Bugge Thomas H; Austin Christopher P; Liu Shihui
Quantitative high-throughput screening identifies inhibitors of anthrax-induced cell death.
Bioorganic & medicinal chemistry 2009;17(14):5139-45.
2009: Moayeri Mahtab; Crown Devorah; Dorward David W; Gardner Don; Ward Jerrold M; Li Yan; Cui Xizhong; Eichacker Peter; Leppla Stephen H
The heart is an early target of anthrax lethal toxin in mice: a protective role for neuronal nitric oxide synthase (nNOS).
PLoS pathogens 2009;5(5):e1000456.
2009: Alfano Randall W; Leppla Stephen H; Liu Shihui; Bugge Thomas H; Meininger Cynthia J; Lairmore Terry C; Mulne Arlynn F; Davis Samuel H; Duesbery Nicholas S; Frankel Arthur E
Matrix metalloproteinase-activated anthrax lethal toxin inhibits endothelial invasion and neovasculature formation during in vitro morphogenesis.
Molecular cancer research : MCR 2009;7(4):452-61.
2009: Li Yan; Cui Xizhong; Su Junwu; Haley Michael; Macarthur Heather; Sherer Kevin; Moayeri Mahtab; Leppla Stephen H; Fitz Yvonne; Eichacker Peter Q
Norepinephrine increases blood pressure but not survival with anthrax lethal toxin in rats.
Critical care medicine 2009;37(4):1348-54.
2009: Sastalla Inka; Chim Kannie; Cheung Gordon Y C; Pomerantsev Andrei P; Leppla Stephen H
Codon-optimized fluorescent proteins designed for expression in low-GC gram-positive bacteria.
Applied and environmental microbiology 2009;75(7):2099-110.
2009: Pomerantsev Andrei P; Pomerantseva Olga M; Camp Andrew S; Mukkamala Radhika; Goldman Stanley; Leppla Stephen H
PapR peptide maturation: role of the NprB protease in Bacillus cereus 569 PlcR/PapR global gene regulation.
FEMS immunology and medical microbiology 2009;55(3):361-77.
2009: Tang Shixing; Moayeri Mahtab; Chen Zhaochun; Harma Harri; Zhao Jiangqin; Hu Haijing; Purcell Robert H; Leppla Stephen H; Hewlett Indira K
Detection of anthrax toxin by an ultrasensitive immunoassay using europium nanoparticles.
Clinical and vaccine immunology : CVI 2009;16(3):408-13.
2009: Liu Shihui; Bugge Thomas H; Frankel Arthur E; Leppla Stephen H
Dissecting the urokinase activation pathway using urokinase-activated anthrax toxin.
Methods in molecular biology (Clifton, N.J.) 2009;539():175-90.
2009: Hobson John P; Liu Shihui; Leppla Stephen H; Bugge Thomas H
Imaging specific cell surface protease activity in living cells using reengineered bacterial cytotoxins.
Methods in molecular biology (Clifton, N.J.) 2009;539():115-29.
2009: Frankel Arthur E; Kuo Shu-Ru; Dostal David; Watson Linley; Duesbery Nicholas S; Cheng Che-Ping; Cheng Heng Jie; Leppla Stephen H
Pathophysiology of anthrax.
Frontiers in bioscience : a journal and virtual library 2009;14():4516-24.
2008: Kastrup Christian J; Boedicker James Q; Pomerantsev Andrei P; Moayeri Mahtab; Bian Yao; Pompano Rebecca R; Kline Timothy R; Sylvestre Patricia; Shen Feng; Leppla Stephen H; Tang Wei-Jen; Ismagilov Rustem F
Spatial localization of bacteria controls coagulation of human blood by 'quorum acting'.
Nature chemical biology 2008;4(12):742-50.
2008: Levin Tera C; Wickliffe Katherine E; Leppla Stephen H; Moayeri Mahtab
Heat shock inhibits caspase-1 activity while also preventing its inflammasome-mediated activation by anthrax lethal toxin.
Cellular microbiology 2008;10(12):2434-46.
2008: Gupta Pradeep K; Liu Shihui; Batavia Mariska P; Leppla Stephen H
The diphthamide modification on elongation factor-2 renders mammalian cells resistant to ricin.
Cellular microbiology 2008;10(8):1687-94.
2008: Kubler-Kielb Joanna; Vinogradov Evgeny; Hu Haijing; Leppla Stephen H; Robbins John B; Schneerson Rachel
Saccharides cross-reactive with Bacillus anthracis spore glycoprotein as an anthrax vaccine component.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(25):8709-12.
2008: Moayeri Mahtab; Robinson Tanisha M; Leppla Stephen H; Karginov Vladimir A
In vivo efficacy of beta-cyclodextrin derivatives against anthrax lethal toxin.
Antimicrobial agents and chemotherapy 2008;52(6):2239-41.
2008: Wickliffe Katherine E; Leppla Stephen H; Moayeri Mahtab
Killing of macrophages by anthrax lethal toxin: involvement of the N-end rule pathway.
Cellular microbiology 2008;10(6):1352-62.
2008: Kuo Shu-Ru; Willingham Mark C; Bour Sarah H; Andreas Elissa A; Park Seong Kyu; Jackson Carney; Duesbery Nicholas S; Leppla Stephen H; Tang Wei-Jen; Frankel Arthur E
Anthrax toxin-induced shock in rats is associated with pulmonary edema and hemorrhage.
Microbial pathogenesis 2008;44(6):467-72.
2008: Alfano Randall W; Leppla Stephen H; Liu Shihui; Bugge Thomas H; Herlyn Meenhard; Smalley Keiran S; Bromberg-White Jennifer L; Duesbery Nicholas S; Frankel Arthur E
Cytotoxicity of the matrix metalloproteinase-activated anthrax lethal toxin is dependent on gelatinase expression and B-RAF status in human melanoma cells.
Molecular cancer therapeutics 2008;7(5):1218-26.
2008: Alfano Randall W; Leppla Stephen H; Liu Shihui; Bugge Thomas H; Duesbery Nicholas S; Frankel Arthur E
Potent inhibition of tumor angiogenesis by the matrix metalloproteinase-activated anthrax lethal toxin: implications for broad anti-tumor efficacy.
Cell cycle (Georgetown, Tex.) 2008;7(6):745-9.
2008: Wickliffe Katherine E; Leppla Stephen H; Moayeri Mahtab
Anthrax lethal toxin-induced inflammasome formation and caspase-1 activation are late events dependent on ion fluxes and the proteasome.
Cellular microbiology 2008;10(2):332-43.
2008: Liu Shihui; Wang Hailun; Currie Brooke M; Molinolo Alfredo; Leung Howard J; Moayeri Mahtab; Basile John R; Alfano Randall W; Gutkind J Silvio; Frankel Arthur E; Bugge Thomas H; Leppla Stephen H
Matrix metalloproteinase-activated anthrax lethal toxin demonstrates high potency in targeting tumor vasculature.
The Journal of biological chemistry 2008;283(1):529-40.
2008: Gupta Pradeep K; Moayeri Mahtab; Crown Devorah; Fattah Rasem J; Leppla Stephen H
Role of N-terminal amino acids in the potency of anthrax lethal factor.
PloS one 2008;3(9):e3130.
2007: Moayeri Mahtab; Wiggins Jason F; Leppla Stephen H
Anthrax protective antigen cleavage and clearance from the blood of mice and rats.
Infection and immunity 2007;75(11):5175-84.
2007: Sherer Kevin; Li Yan; Cui Xizhong; Li Xuemei; Subramanian Mani; Laird Michael W; Moayeri Mahtab; Leppla Stephen H; Fitz Yvonne; Su Junwu; Eichacker Peter Q
Fluid support worsens outcome and negates the benefit of protective antigen-directed monoclonal antibody in a lethal toxin-infused rat Bacillus anthracis shock model.
Critical care medicine 2007;35(6):1560-7.
2007: Firoved Aaron M; Moayeri Mahtab; Wiggins Jason F; Shen Yuequan; Tang Wei-Jen; Leppla Stephen H
Anthrax edema toxin sensitizes DBA/2J mice to lethal toxin.
Infection and immunity 2007;75(5):2120-5.
2007: Su Yunpeng; Ortiz Janelle; Liu Shihui; Bugge Thomas H; Singh Ravibhushan; Leppla Stephen H; Frankel Arthur E
Systematic urokinase-activated anthrax toxin therapy produces regressions of subcutaneous human non-small cell lung tumor in athymic nude mice.
Cancer research 2007;67(7):3329-36.
2007: Liu Shihui; Leung Howard J; Leppla Stephen H
Characterization of the interaction between anthrax toxin and its cellular receptors.
Cellular microbiology 2007;9(4):977-87.
2007: Chen Kuang-Hua; Liu Shihui; Bankston Laurie A; Liddington Robert C; Leppla Stephen H
Selection of anthrax toxin protective antigen variants that discriminate between the cellular receptors TEM8 and CMG2 and achieve targeting of tumor cells.
The Journal of biological chemistry 2007;282(13):9834-45.
2007: Cui Xizhong; Li Yan; Li Xuemei; Laird Michael W; Subramanian Mani; Moayeri Mahtab; Leppla Stephen H; Fitz Yvonne; Su Junwu; Sherer Kevin; Eichacker Peter Q
Bacillus anthracis edema and lethal toxin have different hemodynamic effects but function together to worsen shock and outcome in a rat model.
The Journal of infectious diseases 2007;195(4):572-80.
2007: Shivachandra Sathish B; Li Qin; Peachman Kristina K; Matyas Gary R; Leppla Stephen H; Alving Carl R; Rao Mangala; Rao Venigalla B
Multicomponent anthrax toxin display and delivery using bacteriophage T4.
Vaccine 2007;25(7):1225-35.
2007: Watson Linley E; Kuo Shu-Ru; Katki Khurshed; Dang Tongyun; Park Seong Kyu; Dostal David E; Tang Wei-Jen; Leppla Stephen H; Frankel Arthur E
Anthrax toxins induce shock in rats by depressed cardiac ventricular function.
PloS one 2007;2(5):e466.
2007: Watson Linley E; Mock Jonathan; Lal Hind; Lu Guangrong; Bourdeau Raymond W; Tang Wei-Jen; Leppla Stephen H; Dostal David E; Frankel Arthur E
Lethal and edema toxins of anthrax induce distinct hemodynamic dysfunction.
Frontiers in bioscience : a journal and virtual library 2007;12():4670-5.
2006: Abi-Habib Ralph J; Singh Ravibhushan; Leppla Stephen H; Greene John J; Ding Yan; Berghuis Bree; Duesbery Nicholas S; Frankel Arthur E
Systemic anthrax lethal toxin therapy produces regressions of subcutaneous human melanoma tumors in athymic nude mice.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(24):7437-43.
2006: Abi-Habib Ralph J; Singh Ravibhushan; Liu Shihui; Bugge Thomas H; Leppla Stephen H; Frankel Arthur E
A urokinase-activated recombinant anthrax toxin is selectively cytotoxic to many human tumor cell types.
Molecular cancer therapeutics 2006;5(10):2556-62.
2006: Li Qin; Shivachandra Sathish B; Leppla Stephen H; Rao Venigalla B
Bacteriophage T4 capsid: a unique platform for efficient surface assembly of macromolecular complexes.
Journal of molecular biology 2006;363(2):577-88.
2006: Moayeri Mahtab; Wiggins Jason F; Lindeman Robin E; Leppla Stephen H
Cisplatin inhibition of anthrax lethal toxin.
Antimicrobial agents and chemotherapy 2006;50(8):2658-65.
2006: Moayeri Mahtab; Wickliffe Katherine E; Wiggins Jason F; Leppla Stephen H
Oxidized ATP protection against anthrax lethal toxin.
Infection and immunity 2006;74(7):3707-14.
2006: Mabry Robert; Brasky Kathleen; Geiger Robert; Carrion Ricardo; Hubbard Gene B; Leppla Stephen; Patterson Jean L; Georgiou George; Iverson B L
Detection of anthrax toxin in the serum of animals infected with Bacillus anthracis by using engineered immunoassays.
Clinical and vaccine immunology : CVI 2006;13(6):671-7.
2006: Ogasawara Yoji; Amexis Georgios; Yamaguchi Hiroki; Kajigaya Sachiko; Leppla Stephan H; Young Neal S
Recombinant viral-like particles of parvovirus B19 as antigen carriers of anthrax protective antigen.
In vivo (Athens, Greece) 2006;20(3):319-24.
2006: Liu Shihui; Wiggins Jason F; Sreenath Taduru; Kulkarni Ashok B; Ward Jerrold M; Leppla Stephen H
Dph3, a small protein required for diphthamide biosynthesis, is essential in mouse development.
Molecular and cellular biology 2006;26(10):3835-41.
2006: Hobson John P; Liu Shihui; Rønø Birgitte; Leppla Stephen H; Bugge Thomas H
Imaging specific cell-surface proteolytic activity in single living cells.
Nature methods 2006;3(4):259-61.
2006: Wei Wensheng; Lu Quan; Chaudry G Jilani; Leppla Stephen H; Cohen Stanley N
The LDL receptor-related protein LRP6 mediates internalization and lethality of anthrax toxin.
Cell 2006;124(6):1141-54.
2006: Cui Xizhong; Li Yan; Li Xuemei; Haley Michael; Moayeri Mahtab; Fitz Yvonne; Leppla Stephen H; Eichacker Peter Q
Sublethal doses of Bacillus anthracis lethal toxin inhibit inflammation with lipopolysaccharide and Escherichia coli challenge but have opposite effects on survival.
The Journal of infectious diseases 2006;193(6):829-40.
2006: Chen Zhaochun; Moayeri Mahtab; Zhou Yi-Hua; Leppla Stephen; Emerson Suzanne; Sebrell Andrew; Yu Fujuan; Svitel Juraj; Schuck Peter; St Claire Marisa; Purcell Robert
Efficient neutralization of anthrax toxin by chimpanzee monoclonal antibodies against protective antigen.
The Journal of infectious diseases 2006;193(5):625-33.
2006: Bugge Thomas H; Leppla Stephen H
Anthrax target in macrophages unveiled.
Nature genetics 2006;38(2):137-8.
2006: Gozes Yehoshua; Moayeri Mahtab; Wiggins Jason F; Leppla Stephen H
Anthrax lethal toxin induces ketotifen-sensitive intradermal vascular leakage in certain inbred mice.
Infection and immunity 2006;74(2):1266-72.
2006: Duverger Alexandra; Jackson Raymond J; van Ginkel Frederick W; Fischer Romy; Tafaro Angela; Leppla Stephen H; Fujihashi Kohtaro; Kiyono Hiroshi; McGhee Jerry R; Boyaka Prosper N
Bacillus anthracis edema toxin acts as an adjuvant for mucosal immune responses to nasally administered vaccine antigens.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(3):1776-83.
2006: Shivachandra Sathish B; Rao Mangala; Janosi Laszlo; Sathaliyawala Taheri; Matyas Gary R; Alving Carl R; Leppla Stephen H; Rao Venigalla B
In vitro binding of anthrax protective antigen on bacteriophage T4 capsid surface through Hoc-capsid interactions: a strategy for efficient display of large full-length proteins.
Virology 2006;345(1):190-8.
2006: Rønø Birgitte; Rømer John; Liu Shihui; Bugge Thomas H; Leppla Stephen H; Kristjansen Paul E G
Antitumor efficacy of a urokinase activation-dependent anthrax toxin.
Molecular cancer therapeutics 2006;5(1):89-96.
2006: Abrami Laurence; Leppla Stephen H; van der Goot F Gisou
Receptor palmitoylation and ubiquitination regulate anthrax toxin endocytosis.
The Journal of cell biology 2006;172(2):309-20.
2006: Peachman Kristina K; Rao Mangala; Alving Carl R; Burge Robert; Leppla Stephen H; Rao Venigalla B; Matyas Gary R
Correlation between lethal toxin-neutralizing antibody titers and protection from intranasal challenge with Bacillus anthracis Ames strain spores in mice after transcutaneous immunization with recombinant anthrax protective antigen.
Infection and immunity 2006;74(1):794-7.
2006: Pomerantsev Andrei P; Sitaraman Ramakrishnan; Galloway Craig R; Kivovich Violetta; Leppla Stephen H
Genome engineering in Bacillus anthracis using Cre recombinase.
Infection and immunity 2006;74(1):682-93.
2006: Hu Zonglin; Zhang Aixia; Storz Gisela; Gottesman Susan; Leppla Stephen H
An antibody-based microarray assay for small RNA detection.
Nucleic acids research 2006;34(7):e52.
2005: Koya Vijay; Moayeri Mahtab; Leppla Stephen H; Daniell Henry
Plant-based vaccine: mice immunized with chloroplast-derived anthrax protective antigen survive anthrax lethal toxin challenge.
Infection and immunity 2005;73(12):8266-74.
2005: Firoved Aaron M; Miller Georgina F; Moayeri Mahtab; Kakkar Rahul; Shen Yuequan; Wiggins Jason F; McNally Elizabeth M; Tang Wei-Jen; Leppla Stephen H
Bacillus anthracis edema toxin causes extensive tissue lesions and rapid lethality in mice.
The American journal of pathology 2005;167(5):1309-20.
2005: Karginov Vladimir A; Nestorovich Ekaterina M; Moayeri Mahtab; Leppla Stephen H; Bezrukov Sergey M
Blocking anthrax lethal toxin at the protective antigen channel by using structure-inspired drug design.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(42):15075-80.
2005: Abi-Habib Ralph J; Urieto Jeffrey O; Liu Shihui; Leppla Stephen H; Duesbery Nicholas S; Frankel Arthur E
BRAF status and mitogen-activated protein/extracellular signal-regulated kinase kinase 1/2 activity indicate sensitivity of melanoma cells to anthrax lethal toxin.
Molecular cancer therapeutics 2005;4(9):1303-10.
2005: Moayeri Mahtab; Webster Jeanette I; Wiggins Jason F; Leppla Stephen H; Sternberg Esther M
Endocrine perturbation increases susceptibility of mice to anthrax lethal toxin.
Infection and immunity 2005;73(7):4238-44.
2005: Liu Shihui; Redeye Vivien; Kuremsky Jeffrey G; Kuhnen Marissa; Molinolo Alfredo; Bugge Thomas H; Leppla Stephen H
Intermolecular complementation achieves high-specificity tumor targeting by anthrax toxin.
Nature biotechnology 2005;23(6):725-30.
2005: Cui Xizhong; Li Yan; Moayeri Mahtab; Choi Gil H; Subramanian G M; Li Xuemei; Haley Michael; Fitz Yvonne; Feng Jing; Banks Steven M; Leppla Stephen H; Eichacker Peter Q
Late treatment with a protective antigen-directed monoclonal antibody improves hemodynamic function and survival in a lethal toxin-infused rat model of anthrax sepsis.
The Journal of infectious diseases 2005;191(3):422-34.
2004: Westcott Marlena M; Abi-Habib Ralph J; Cohen Kimberley A; Willingham Mark C; Liu Shihui; Bugge Thomas H; Leppla Stephen H; Frankel Arthur E
Diphtheria toxin-murine granulocyte-macrophage colony-stimulating factor-induced hepatotoxicity is mediated by Kupffer cells.
Molecular cancer therapeutics 2004;3(12):1681-9.
2004: Ren Gang; Quispe Joel; Leppla Stephen H; Mitra Alok K
Large-scale structural changes accompany binding of lethal factor to anthrax protective antigen: a cryo-electron microscopic study.
Structure (London, England : 1993) 2004;12(11):2059-66.
2004: Liu Shihui; Milne G Todd; Kuremsky Jeffrey G; Fink Gerald R; Leppla Stephen H
Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2.
Molecular and cellular biology 2004;24(21):9487-97.
2004: Watson Jennifer; Koya Vijay; Leppla Stephen H; Daniell Henry
Expression of Bacillus anthracis protective antigen in transgenic chloroplasts of tobacco, a non-food/feed crop.
Vaccine 2004;22(31-32):4374-84.
2004: Pomerantsev Andrei P; Pomerantseva Olga M; Leppla Stephen H
A spontaneous translational fusion of Bacillus cereus PlcR and PapR activates transcription of PlcR-dependent genes in Bacillus anthracis via binding with a specific palindromic sequence.
Infection and immunity 2004;72(10):5814-23.
2004: Abi-Habib Ralph J; Liu Shihui; Bugge Thomas H; Leppla Stephen H; Frankel Arthur E
A urokinase-activated recombinant diphtheria toxin targeting the granulocyte-macrophage colony-stimulating factor receptor is selectively cytotoxic to human acute myeloid leukemia blasts.
Blood 2004;104(7):2143-8.
2004: Peinado Juan R; Kacprzak Magdalena M; Leppla Stephen H; Lindberg Iris
Cross-inhibition between furin and lethal factor inhibitors.
Biochemical and biophysical research communications 2004;321(3):601-5.
2004: Abrami Laurence; Lindsay Margaret; Parton Robert G; Leppla Stephen H; van der Goot F Gisou
Membrane insertion of anthrax protective antigen and cytoplasmic delivery of lethal factor occur at different stages of the endocytic pathway.
The Journal of cell biology 2004;166(5):645-51.
2004: Moayeri Mahtab; Martinez Nathaniel W; Wiggins Jason; Young Howard A; Leppla Stephen H
Mouse susceptibility to anthrax lethal toxin is influenced by genetic factors in addition to those controlling macrophage sensitivity.
Infection and immunity 2004;72(8):4439-47.
2004: Santelli Eugenio; Bankston Laurie A; Leppla Stephen H; Liddington Robert C
Crystal structure of a complex between anthrax toxin and its host cell receptor.
Nature 2004;430(7002):905-8.
2004: Cui Xizhong; Moayeri Mahtab; Li Yan; Li Xuemei; Haley Michael; Fitz Yvonne; Correa-Araujo Rosaly; Banks Steven M; Leppla Stephen H; Eichacker Peter Q
Lethality during continuous anthrax lethal toxin infusion is associated with circulatory shock but not inflammatory cytokine or nitric oxide release in rats.
American journal of physiology. Regulatory, integrative and comparative physiology 2004;286(4):R699-709.
2004: Moayeri Mahtab; Leppla Stephen H
The roles of anthrax toxin in pathogenesis.
Current opinion in microbiology 2004;7(1):19-24.
2004: Turk Benjamin E; Wong Thiang Yian; Schwarzenbacher Robert; Jarrell Emily T; Leppla Stephen H; Collier R John; Liddington Robert C; Cantley Lewis C
The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor.
Nature structural & molecular biology 2004;11(1):60-6.
2004: Sarac Miroslav S; Peinado Juan R; Leppla Stephen H; Lindberg Iris
Protection against anthrax toxemia by hexa-D-arginine in vitro and in vivo.
Infection and immunity 2004;72(1):602-5.
2003: Pomerantsev A P; Kalnin K V; Osorio M; Leppla S H
Phosphatidylcholine-specific phospholipase C and sphingomyelinase activities in bacteria of the Bacillus cereus group.
Infection and immunity 2003;71(11):6591-606.
2003: Liu Shihui; Leppla Stephen H
Retroviral insertional mutagenesis identifies a small protein required for synthesis of diphthamide, the target of bacterial ADP-ribosylating toxins.
Molecular cell 2003;12(3):603-13.
2003: Moayeri Mahtab; Haines Diana; Young Howard A; Leppla Stephen H
Bacillus anthracis lethal toxin induces TNF-alpha-independent hypoxia-mediated toxicity in mice.
The Journal of clinical investigation 2003;112(5):670-82.
2003: Frankel Arthur E; Neville David M; Bugge Thomas A; Kreitman Robert J; Leppla Stephen H
Immunotoxin therapy of hematologic malignancies.
Seminars in oncology 2003;30(4):545-57.
2003: Liu Shihui; Schubert Rebecca L; Bugge Thomas H; Leppla Stephen H
Anthrax toxin: structures, functions and tumour targeting.
Expert opinion on biological therapy 2003;3(5):843-53.
2003: Rosovitz M J; Schuck Peter; Varughese Mini; Chopra Arun P; Mehra Varsha; Singh Yogendra; McGinnis Lisa M; Leppla Stephen H
Alanine-scanning mutations in domain 4 of anthrax toxin protective antigen reveal residues important for binding to the cellular receptor and to a neutralizing monoclonal antibody.
The Journal of biological chemistry 2003;278(33):30936-44.
2003: Agrawal Anshu; Lingappa Jai; Leppla Stephen H; Agrawal Sudhanshu; Jabbar Abdul; Quinn Conrad; Pulendran Bali
Impairment of dendritic cells and adaptive immunity by anthrax lethal toxin.
Nature 2003;424(6946):329-34.
2003: Schneerson Rachel; Kubler-Kielb Joanna; Liu Teh-Yung; Dai Zhong-Dong; Leppla Stephen H; Yergey Alfred; Backlund Peter; Shiloach Joseph; Majadly Fathy; Robbins John B
Poly(gamma-D-glutamic acid) protein conjugates induce IgG antibodies in mice to the capsule of Bacillus anthracis: a potential addition to the anthrax vaccine.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(15):8945-50.
2003: Boyaka Prosper N; Tafaro Angela; Fischer Romy; Leppla Stephen H; Fujihashi Kohtaro; McGhee Jerry R
Effective mucosal immunity to anthrax: neutralizing antibodies and Th cell responses following nasal immunization with protective antigen.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(11):5636-43.
2003: Webster Jeanette I; Tonelli Leonardo H; Moayeri Mahtab; Simons S Stoney; Leppla Stephen H; Sternberg Esther M
Anthrax lethal factor represses glucocorticoid and progesterone receptor activity.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(10):5706-11.
2003: Abrami Laurence; Liu Shihui; Cosson Pierre; Leppla Stephen H; van der Goot F Gisou
Anthrax toxin triggers endocytosis of its receptor via a lipid raft-mediated clathrin-dependent process.
The Journal of cell biology 2003;160(3):321-8.
2003: Liu Shihui; Leppla Stephen H
Cell surface tumor endothelium marker 8 cytoplasmic tail-independent anthrax toxin binding, proteolytic processing, oligomer formation, and internalization.
The Journal of biological chemistry 2003;278(7):5227-34.
2003: Liu Shihui; Aaronson Hannah; Mitola David J; Leppla Stephen H; Bugge Thomas H
Potent antitumor activity of a urokinase-activated engineered anthrax toxin.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(2):657-62.
2003: Frankel Arthur E; Koo Han-Mo; Leppla Stephen H; Duesbery Nicholas S; Vande Woude George F
Novel protein targeted therapy of metastatic melanoma.
Current pharmaceutical design 2003;9(25):2060-6.
2002: Frankel Arthur E; Powell Bayard L; Duesbery Nick S; Vande Woude George F; Leppla Stephen H
Anthrax fusion protein therapy of cancer.
Current protein & peptide science 2002;3(4):399-407.
2002: Rosovitz M J; Leppla Stephen H
Virus deals anthrax a killer blow.
Nature 2002;418(6900):825-6.
2002: Leppla Stephen H; Robbins John B; Schneerson Rachel; Shiloach Joseph
Development of an improved vaccine for anthrax.
The Journal of clinical investigation 2002;110(2):141-4.
2002: Maynard Jennifer A; Maassen Catharina B M; Leppla Stephen H; Brasky Kathleen; Patterson Jean L; Iverson Brent L; Georgiou George
Protection against anthrax toxin by recombinant antibody fragments correlates with antigen affinity.
Nature biotechnology 2002;20(6):597-601.
2002: Koo Han-Mo; VanBrocklin Matt; McWilliams Mary Jane; Leppla Stephan H; Duesbery Nicholas S; Woude George F Vande
Apoptosis and melanogenesis in human melanoma cells induced by anthrax lethal factor inactivation of mitogen-activated protein kinase kinase.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(5):3052-7.
2002: Frankel Arthur E; Bugge Thomas H; Liu Shihui; Vallera Daniel A; Leppla Stephen H
Peptide toxins directed at the matrix dissolution systems of cancer cells.
Protein and peptide letters 2002;9(1):1-14.
2002: Chaudry G Jilani; Moayeri Mahtab; Liu Shihui; Leppla Stephen H
Quickening the pace of anthrax research: three advances point towards possible therapies.
Trends in microbiology 2002;10(2):58-62.
2001: Pannifer A D; Wong T Y; Schwarzenbacher R; Renatus M; Petosa C; Bienkowska J; Lacy D B; Collier R J; Park S; Leppla S H; Hanna P; Liddington R C
Crystal structure of the anthrax lethal factor.
Nature 2001;414(6860):229-33.
2001: Liu S; Bugge T H; Leppla S H
Targeting of tumor cells by cell surface urokinase plasminogen activator-dependent anthrax toxin.
The Journal of biological chemistry 2001;276(21):17976-84.
2001: Duesbery N S; Resau J; Webb C P; Koochekpour S; Koo H M; Leppla S H; Vande Woude G F
Suppression of ras-mediated transformation and inhibition of tumor growth and angiogenesis by anthrax lethal factor, a proteolytic inhibitor of multiple MEK pathways.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(7):4089-94.
2000: Liu S; Netzel-Arnett S; Birkedal-Hansen H; Leppla S H
Tumor cell-selective cytotoxicity of matrix metalloproteinase-activated anthrax toxin.
Cancer research 2000;60(21):6061-7.
2000: Park S; Leppla S H
Optimized production and purification of Bacillus anthracis lethal factor.
Protein expression and purification 2000;18(3):293-302.
1999: Gordon V M; Nelson K L; Buckley J T; Stevens V L; Tweten R K; Elwood P C; Leppla S H
Clostridium septicum alpha toxin uses glycosylphosphatidylinositol-anchored protein receptors.
The Journal of biological chemistry 1999;274(38):27274-80.
1999: Tang G; Leppla S H
Proteasome activity is required for anthrax lethal toxin to kill macrophages.
Infection and immunity 1999;67(6):3055-60.
1999: Varughese M; Teixeira A V; Liu S; Leppla S H
Identification of a receptor-binding region within domain 4 of the protective antigen component of anthrax toxin.
Infection and immunity 1999;67(4):1860-5.
1999: Singh Y; Klimpel K R; Goel S; Swain P K; Leppla S H
Oligomerization of anthrax toxin protective antigen and binding of lethal factor during endocytic uptake into mammalian cells.
Infection and immunity 1999;67(4):1853-9.
1998: Abrami L; Fivaz M; Decroly E; Seidah N G; Jean F; Thomas G; Leppla S H; Buckley J T; van der Goot F G
The pore-forming toxin proaerolysin is activated by furin.
The Journal of biological chemistry 1998;273(49):32656-61.
1998: Duesbery N S; Webb C P; Leppla S H; Gordon V M; Klimpel K R; Copeland T D; Ahn N G; Oskarsson M K; Fukasawa K; Paull K D; Vande Woude G F
Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor.
Science (New York, N.Y.) 1998;280(5364):734-7.
1998: Varughese M; Chi A; Teixeira A V; Nicholls P J; Keith J M; Leppla S H
Internalization of a Bacillus anthracis protective antigen-c-Myc fusion protein mediated by cell surface anti-c-Myc antibodies.
Molecular medicine (Cambridge, Mass.) 1998;4(2):87-95.
1997: Goletz T J; Klimpel K R; Arora N; Leppla S H; Keith J M; Berzofsky J A
Targeting HIV proteins to the major histocompatibility complex class I processing pathway with a novel gp120-anthrax toxin fusion protein.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(22):12059-64.
1997: Gordon V M; Benz R; Fujii K; Leppla S H; Tweten R K
Clostridium septicum alpha-toxin is proteolytically activated by furin.
Infection and immunity 1997;65(10):4130-4.
1997: Gordon V M; Rehemtulla A; Leppla S H
A role for PACE4 in the proteolytic activation of anthrax toxin protective antigen.
Infection and immunity 1997;65(8):3370-5.
1997: Goletz T J; Klimpel K R; Leppla S H; Keith J M; Berzofsky J A
Delivery of antigens to the MHC class I pathway using bacterial toxins.
Human immunology 1997;54(2):129-36.
1997: Petosa C; Collier R J; Klimpel K R; Leppla S H; Liddington R C
Crystal structure of the anthrax toxin protective antigen.
Nature 1997;385(6619):833-8.
1996: Little S F; Novak J M; Lowe J R; Leppla S H; Singh Y; Klimpel K R; Lidgerding B C; Friedlander A M
Characterization of lethal factor binding and cell receptor binding domains of protective antigen of Bacillus anthracis using monoclonal antibodies.
Microbiology (Reading, England) 1996;142 ( Pt 3)():707-15.
1996: Gu M; Gordon V M; Fitzgerald D J; Leppla S H
Furin regulates both the activation of Pseudomonas exotoxin A and the Quantity of the toxin receptor expressed on target cells.
Infection and immunity 1996;64(2):524-7.
1995: FitzGerald D J; Fryling C M; Zdanovsky A; Saelinger C B; Kounnas M; Winkles J A; Strickland D; Leppla S
Pseudomonas exotoxin-mediated selection yields cells with altered expression of low-density lipoprotein receptor-related protein.
The Journal of cell biology 1995;129(6):1533-41.
1995: Gu M; Rappaport J; Leppla S H
Furin is important but not essential for the proteolytic maturation of gp160 of HIV-1.
FEBS letters 1995;365(1):95-7.
1995: Friedman T C; Gordon V M; Leppla S H; Klimpel K R; Birch N P; Loh Y P
In vitro processing of anthrax toxin protective antigen by recombinant PC1 (SPC3) and bovine intermediate lobe secretory vesicle membranes.
Archives of biochemistry and biophysics 1995;316(1):5-13.
1995: Gordon V M; Klimpel K R; Arora N; Henderson M A; Leppla S H
Proteolytic activation of bacterial toxins by eukaryotic cells is performed by furin and by additional cellular proteases.
Infection and immunity 1995;63(1):82-7.
1994: Singh Y; Klimpel K R; Arora N; Sharma M; Leppla S H
The chymotrypsin-sensitive site, FFD315, in anthrax toxin protective antigen is required for translocation of lethal factor.
The Journal of biological chemistry 1994;269(46):29039-46.
1994: Arora N; Leppla S H
Fusions of anthrax toxin lethal factor with shiga toxin and diphtheria toxin enzymatic domains are toxic to mammalian cells.
Infection and immunity 1994;62(11):4955-61.
1994: Arora N; Williamson L C; Leppla S H; Halpern J L
Cytotoxic effects of a chimeric protein consisting of tetanus toxin light chain and anthrax toxin lethal factor in non-neuronal cells.
The Journal of biological chemistry 1994;269(42):26165-71.
1994: Fitzgerald D J; Fryling C M; Zdanovsky A; Saelinger C B; Kounnas M; Strickland D K; Leppla S
Selection of Pseudomonas exotoxin-resistant cells with altered expression of alpha 2MR/LRP.
Annals of the New York Academy of Sciences 1994;737():138-44.
1994: Klimpel K R; Arora N; Leppla S H
Anthrax toxin lethal factor contains a zinc metalloprotease consensus sequence which is required for lethal toxin activity.
Molecular microbiology 1994;13(6):1093-100.
1994: Little S F; Leppla S H; Burnett J W; Friedlander A M
Structure-function analysis of Bacillus anthracis edema factor by using monoclonal antibodies.
Biochemical and biophysical research communications 1994;199(2):676-82.
1994: Gordon V M; Leppla S H
Proteolytic activation of bacterial toxins: role of bacterial and host cell proteases.
Infection and immunity 1994;62(2):333-40.
1993: Uchida I; Hornung J M; Thorne C B; Klimpel K R; Leppla S H
Cloning and characterization of a gene whose product is a trans-activator of anthrax toxin synthesis.
Journal of bacteriology 1993;175(17):5329-38.
1993: Arora N; Leppla S H
Residues 1-254 of anthrax toxin lethal factor are sufficient to cause cellular uptake of fused polypeptides.
The Journal of biological chemistry 1993;268(5):3334-41.
1993: Friedlander A M; Bhatnagar R; Leppla S H; Johnson L; Singh Y
Characterization of macrophage sensitivity and resistance to anthrax lethal toxin.
Infection and immunity 1993;61(1):245-52.
1992: Klimpel K R; Molloy S S; Thomas G; Leppla S H
Anthrax toxin protective antigen is activated by a cell surface protease with the sequence specificity and catalytic properties of furin.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(21):10277-81.
1992: Molloy S S; Bresnahan P A; Leppla S H; Klimpel K R; Thomas G
Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen.
The Journal of biological chemistry 1992;267(23):16396-402.
1992: Arora N; Klimpel K R; Singh Y; Leppla S H
Fusions of anthrax toxin lethal factor to the ADP-ribosylation domain of Pseudomonas exotoxin A are potent cytotoxins which are translocated to the cytosol of mammalian cells.
The Journal of biological chemistry 1992;267(22):15542-8.
1992: Novak J M; Stein M P; Little S F; Leppla S H; Friedlander A M
Functional characterization of protease-treated Bacillus anthracis protective antigen.
The Journal of biological chemistry 1992;267(24):17186-93.
1991: Quinn C P; Singh Y; Klimpel K R; Leppla S H
Functional mapping of anthrax toxin lethal factor by in-frame insertion mutagenesis.
The Journal of biological chemistry 1991;266(30):20124-30.
1991: Singh Y; Klimpel K R; Quinn C P; Chaudhary V K; Leppla S H
The carboxyl-terminal end of protective antigen is required for receptor binding and anthrax toxin activity.
The Journal of biological chemistry 1991;266(23):15493-7.
1990: Little S F; Leppla S H; Friedlander A M
Production and characterization of monoclonal antibodies against the lethal factor component of Bacillus anthracis lethal toxin.
Infection and immunity 1990;58(6):1606-13.
1989: Singh Y; Chaudhary V K; Leppla S H
A deleted variant of Bacillus anthracis protective antigen is non-toxic and blocks anthrax toxin action in vivo.
The Journal of biological chemistry 1989;264(32):19103-7.
1989: Gordon V M; Young W W; Lechler S M; Gray M C; Leppla S H; Hewlett E L
Adenylate cyclase toxins from Bacillus anthracis and Bordetella pertussis. Different processes for interaction with and entry into target cells.
The Journal of biological chemistry 1989;264(25):14792-6.
1989: Bartkus J M; Leppla S H
Transcriptional regulation of the protective antigen gene of Bacillus anthracis.
Infection and immunity 1989;57(8):2295-300.
1989: Singh Y; Leppla S H; Bhatnagar R; Friedlander A M
Internalization and processing of Bacillus anthracis lethal toxin by toxin-sensitive and -resistant cells.
The Journal of biological chemistry 1989;264(19):11099-102.
1989: Bhatnagar R; Singh Y; Leppla S H; Friedlander A M
Calcium is required for the expression of anthrax lethal toxin activity in the macrophagelike cell line J774A.1.
Infection and immunity 1989;57(7):2107-14.
1988: Welkos S L; Lowe J R; Eden-McCutchan F; Vodkin M; Leppla S H; Schmidt J J
Sequence and analysis of the DNA encoding protective antigen of Bacillus anthracis.
Gene 1988;69(2):287-300.
1988: Little S F; Leppla S H; Cora E
Production and characterization of monoclonal antibodies to the protective antigen component of Bacillus anthracis toxin.
Infection and immunity 1988;56(7):1807-13.
1988: Gordon V M; Leppla S H; Hewlett E L
Inhibitors of receptor-mediated endocytosis block the entry of Bacillus anthracis adenylate cyclase toxin but not that of Bordetella pertussis adenylate cyclase toxin.
Infection and immunity 1988;56(5):1066-9.
1988: Larson D K; Calton G J; Little S F; Leppla S H; Burnett J W
Separation of three exotoxic factors of Bacillus anthracis by sequential immunosorbent chromatography.
Toxicon : official journal of the International Society on Toxinology 1988;26(10):913-21.
1988: Turnbull P C; Leppla S H; Broster M G; Quinn C P; Melling J
Antibodies to anthrax toxin in humans and guinea pigs and their relevance to protective immunity.
Medical microbiology and immunology 1988;177(5):293-303.
1986: Ivins B E; Ezzell J W; Jemski J; Hedlund K W; Ristroph J D; Leppla S H
Immunization studies with attenuated strains of Bacillus anthracis.
Infection and immunity 1986;52(2):454-8.
1984: Manhart M D; Morris R E; Bonventre P F; Leppla S; Saelinger C B
Evidence for pseudomonas exotoxin A receptors on plasma membrane of toxin-sensitive lm fibroblasts.
Infection and immunity 1984;45(3):596-603.
1984: Ezzell J W; Ivins B E; Leppla S H
Immunoelectrophoretic analysis, toxicity, and kinetics of in vitro production of the protective antigen and lethal factor components of Bacillus anthracis toxin.
Infection and immunity 1984;45(3):761-7.

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