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Ake Lernmark

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C Andersson; Annelie Carlsson; Aj Delli; G Forsander; Sten-A Ivarsson; H Elding Larsson; Ake Lernmark; Bengt Lindblad; Johnny Ludvigsson; C Marcus; Ulf Samuelsson; Fariba Vaziri-Sani
Triple specificity of ZnT8 autoantibodies in relation to HLA and other islet autoantibodies in childhood and adolescent type 1 diabetes.
Ake Lernmark; Helena Elding Larsson
Immune therapy in type 1 diabetes mellitus.
H Skärstrand; Ake Lernmark; Fariba Vaziri-Sani
Antigenicity and epitope specificity of ZnT8 autoantibodies in type 1 diabetes.

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All Publications

2013: C Andersson; Annelie Carlsson; Aj Delli; G Forsander; Sten-A Ivarsson; H Elding Larsson; Ake Lernmark; Bengt Lindblad; Johnny Ludvigsson; C Marcus; Ulf Samuelsson; Fariba Vaziri-Sani
Triple specificity of ZnT8 autoantibodies in relation to HLA and other islet autoantibodies in childhood and adolescent type 1 diabetes.
Pediatric diabetes 2013;14(2):97-105.
2013: Ake Lernmark; Helena Elding Larsson
Immune therapy in type 1 diabetes mellitus.
Nature reviews. Endocrinology 2013;9(2):92-103.
2013: H Skärstrand; Ake Lernmark; Fariba Vaziri-Sani
Antigenicity and epitope specificity of ZnT8 autoantibodies in type 1 diabetes.
Scandinavian journal of immunology 2013;77(1):21-9.
2013: Marika Bogdani; Yi-Guang Chen; Jessica M Fuller; Rhonda Geoffrey; Angela M Henschel; Shuang Jia; Mary L Kaldunski; Sanjay Kansra; Ake Lernmark; Scott Pavletich; Simon Prosser; Martin J Hessner
Biobreeding rat islets exhibit reduced antioxidative defense and N-acetyl cysteine treatment delays type 1 diabetes.
The Journal of endocrinology 2013;216(2):111-23.
2012: A Gyllenberg; S A Ivarsson; Ingrid Kockum; M Landin-Olsson; H Larsson; Ake Lernmark; B Lindblad; E Lindholm; J Ludvigsson; C Marcus; B McNeney; Tomas Olsson; M Orho-Melander; Leonid Padyukov; Fredrik Piehl; E A Rutledge; Maria Swanberg; Brian Van Yserloo; K Akesson; K Akesson; Lars Alfredsson; S Asad; A Carlsson; G Forsander; C Forsell; C Graff; J Graham
Age-dependent variation of genotypes in MHC II transactivator gene (CIITA) in controls and association to type 1 diabetes.
Genes and immunity 2012;13(8):632-40.
2012: Huriya Beyan; Bernhard O Boehm; Corrado M Cilio; Thomas A Down; George C Ebers; Carolina Gemma; Gavin Giovannoni; Michelle L Holland; R David Leslie; Anita Nilsson; Sreeram V Ramagopalan; Kristina Uvebrant; Ake Lernmark; Vardhman K Rakyan
Guthrie card methylomics identifies temporally stable epialleles that are present at birth in humans.
Genome research 2012;22(11):2138-45.
2012: Ahmed J Delli; Helena Elding-Larsson; Gun Forsander; Leif Groop; Sten-A Ivarsson; Ingrid Kockum; Ake Lernmark; Bengt Lindblad; Johnny Ludvigsson; Claude Marcus; Eva Örtqvist; George K Papadopoulos; Ulf Samuelsson; Fariba Vaziri-Sani; George P Bondinas; Annelie Carlsson
Zinc transporter 8 autoantibodies and their association with SLC30A8 and HLA-DQ genes differ between immigrant and Swedish patients with newly diagnosed type 1 diabetes in the Better Diabetes Diagnosis study.
Diabetes 2012;61(10):2556-64.
2012: Marie Louise M Andersen; Ahmed Delli; Lars Hansen; Emma Jacobssen; Ake Lernmark; Henrik B Mortensen; Sven Pörksen; Jacob Steen Petersen; Jannet Svensson; Jane Thomsen; Fariba Vaziri-Sani; Lotte B Nielsen
Association between autoantibodies to the Arginine variant of the Zinc transporter 8 (ZnT8) and stimulated C-peptide levels in Danish children and adolescents with newly diagnosed type 1 diabetes.
Pediatric diabetes 2012;13(6):454-62.
2012: Sabina Rešić Lindehammer; Hanna Honkanen; Heikki Hyöty; Ida Jönsson; Kristian Francis Lynch; Karel Marsal; William Allan Nix; Steven Oberste; Maarit Oikarinen; Ake Lernmark
Seroconversion to islet autoantibodies after enterovirus infection in early pregnancy.
Viral immunology 2012;25(4):254-61.
2012: J S Sorensen; Fariba Vaziri-Sani; N H Birkebaek; N Breslow; C Brorsson; A Ellerman; K Kristensen; Ake Lernmark; M Maziarz; Flemming Pociot
Islet autoantibodies and residual beta cell function in type 1 diabetes children followed for 3-6 years.
Diabetes research and clinical practice 2012;96(2):204-10.
2012: Anastasia Papadopoulou; Ake Lernmark; Carl-David Agardh; Eva Anderberg; Ida Hansson; Mona Landin-Olsson; Kristian F Lynch; Kerstin Berntorp
HLA-DQB1 genotypes and islet cell autoantibodies against GAD65 and IA-2 in relation to development of diabetes post partum in women with gestational diabetes mellitus.
Diabetes research and clinical practice 2012;95(2):260-4.
2012: Johnny Ludvigsson; C Marcus; A Carlsson; G Forsander; S Ivarsson; I Kockum; Ake Lernmark; B Lindblad; Ulf Samuelsson
C-peptide in the classification of diabetes in children and adolescents.
Pediatric diabetes 2012;13(1):45-50.
2012: Samina Asad; Hedvig Bennet; Annelie Carlsson; Malin Fex; Gun Forsander; Alexandra Gyllenberg; Ola Hansson; Sten-Anders Ivarsson; Helena Larsson; Bengt Lindblad; Johnny Ludvigsson; Holger Luthman; Claude Marcus; Jan Nerup; Pernilla Nikamo; Flemming Pociot; Kjersti S Rønningen; Nils Wierup; Ake Lernmark; Ingrid Kockum
HTR1A a novel type 1 diabetes susceptibility gene on chromosome 5p13-q13.
PloS one 2012;7(5):e35439.
2011: Lotte B Nielsen; Flemming Pociot; Sven Pörksen; Jannet Svensson; Fariba Vaziri-Sani; Marie-Louise M Andersen; Regine Bergholdt; Luis Castaño; Carine de Beaufort; Lars Hansen; Philip Hougaard; Ake Lernmark; Henrik B Mortensen
Relationship between ZnT8Ab, the SLC30A8 gene and disease progression in children with newly diagnosed type 1 diabetes.
Autoimmunity 2011;44(8):616-23.
2011: Daniel H Moralejo; William Osborne; Elizabeth A Rutledge; Brian Van Yserloo; Ruth A Ettinger; Jessica M Fuller; Richard Jensen; Anne Kwitek; Ake Lernmark
BB rat Gimap gene expression in sorted lymphoid T and B cells.
Life sciences 2011;89(19-20):748-54.
2011: A Papadopoulou; N Shaat; Carl-David Agardh; Kerstin Berntorp; R Håkansson; Sten-A Ivarsson; Ake Lernmark; K F Lynch
Gestational diabetes mellitus is associated with TCF7L2 gene polymorphisms independent of HLA-DQB1*0602 genotypes and islet cell autoantibodies.
Diabetic medicine : a journal of the British Diabetic Association 2011;28(9):1018-27.
2011: Fariba Vaziri-Sani; Annelie Carlsson; Ahmed J Delli; Helena Elding-Larsson; Gun Forsander; Sten-A Ivarsson; Bengt Lindblad; Johnny Ludvigsson; Claude Marcus; Ake Lernmark
A novel triple mix radiobinding assay for the three ZnT8 (ZnT8-RWQ) autoantibody variants in children with newly diagnosed diabetes.
Journal of immunological methods 2011;371(1-2):25-37.
2011: David B Sacks; Mark Arnold; George L Bakris; David E Bruns; Andrea Rita Horvath; M Sue Kirkman; Ake Lernmark; Boyd E Metzger; David M Nathan
Executive summary: guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus.
Clinical chemistry 2011;57(6):793-8.
2011: David B Sacks; Mark Arnold; George L Bakris; David E Bruns; Andrea Rita Horvath; M Sue Kirkman; Ake Lernmark; Boyd E Metzger; David M Nathan
Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus.
Clinical chemistry 2011;57(6):e1-e47.
2011: David B Sacks; Mark Arnold; George L Bakris; David E Bruns; Andrea Rita Horvath; M Sue Kirkman; Ake Lernmark; Boyd E Metzger; David M Nathan
Position statement executive summary: guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus.
Diabetes care 2011;34(6):1419-23.
2011: David B Sacks; Mark Arnold; George L Bakris; David E Bruns; Andrea Rita Horvath; M Sue Kirkman; Ake Lernmark; Boyd E Metzger; David M Nathan
Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus.
Diabetes care 2011;34(6):e61-99.
2011: Daniel H Moralejo; Ofer Yanay; Kelly Kernan; Adam Bailey; Ake Lernmark; William R A Osborne
Sustained glucagon-like peptide 1 expression from encapsulated transduced cells to treat obese diabetic rats.
Journal of bioscience and bioengineering 2011;111(4):383-7.
2011: Stefanie Eising; Anita Nilsson; Bendix Carstensen; David M Hougaard; Bent Nørgaard-Pedersen; Jørn Nerup; Ake Lernmark; Flemming Pociot
Danish children born with glutamic acid decarboxylase-65 and islet antigen-2 autoantibodies at birth had an increased risk to develop type 1 diabetes.
European journal of endocrinology / European Federation of Endocrine Societies 2011;164(2):247-52.
2011: Simon E Regnell; Ake Lernmark
Hepatic steatosis in type 1 diabetes.
The review of diabetic studies : RDS 2011;8(4):454-67.
2011: Richard A Jensen; Elisabet Agardh; Ake Lernmark; Soffia Gudbjörnsdottir; Nicholas L Smith; David S Siscovick; Carina Törn
HLA genes, islet autoantibodies and residual C-peptide at the clinical onset of type 1 diabetes mellitus and the risk of retinopathy 15 years later.
PloS one 2011;6(3):e17569.
2011: Helena Elding Larsson; Ake Lernmark
Does immune-tolerance treatment with Alum-formulated GAD65 protect insulin-production in the pancreatic islet β cells?
Human vaccines 2011;7(1):45-9.
2011: Suresh Kumar Mendu; Lina Akesson; Zhe Jin; Anna Edlund; Corrado Cilio; Ake Lernmark; Bryndis Birnir
Increased GABA(A) channel subunits expression in CD8(+) but not in CD4(+) T cells in BB rats developing diabetes compared to their congenic littermates.
Molecular immunology 2011;48(4):399-407.
2011: Sabina Resic Lindehammer; Ida Hansson; Bo Midberg; Sten Anders Ivarsson; Kristian Francis Lynch; Joakim Dillner; Ake Lernmark
Seroconversion to islet autoantibodies between early pregnancy and delivery in non-diabetic mothers.
Journal of reproductive immunology 2011;88(1):72-9.
2010: Ahmed J Delli; Bengt Lindblad; Annelie Carlsson; Gun Forsander; Sten-A Ivarsson; Johnny Ludvigsson; Claude Marcus; Ake Lernmark
Type 1 diabetes patients born to immigrants to Sweden increase their native diabetes risk and differ from Swedish patients in HLA types and islet autoantibodies.
Pediatric diabetes 2010;11(8):513-20.
2010: Mary Kaldunski; Sanjay Kansra; Ake Lernmark; John P Mordes; Simon Prosser; Xujing Wang; Joel Basken; Rhonda Geoffrey; Shuang Jia; Martin J Hessner
Identification of a serum-induced transcriptional signature associated with type 1 diabetes in the BioBreeding rat.
Diabetes 2010;59(10):2375-85.
2010: K F Lynch; S V Subramanian; H Ohlsson; Basile Chaix; Ake Lernmark; Juan Merlo
Context and disease when disease risk is low: the case of type 1 diabetes in Sweden.
Journal of epidemiology and community health 2010;64(9):789-95.
2010: M Maziarz; Marta Janer; Jared C Roach; William Hagopian; Jerry P Palmer; K Deutsch; Carani B Sanjeevi; Ingrid Kockum; Norman E Breslow; Ake Lernmark
The association between the PTPN22 1858C>T variant and type 1 diabetes depends on HLA risk and GAD65 autoantibodies.
Genes and immunity 2010;11(5):406-15.
2010: C Akesson; K Uvebrant; C Oderup; Kristian Lynch; R A Harris; Ake Lernmark; Carl-David Agardh; Corrado M Cilio
Altered natural killer (NK) cell frequency and phenotype in latent autoimmune diabetes in adults (LADA) prior to insulin deficiency.
Clinical and experimental immunology 2010;161(1):48-56.
2010: Ofer Yanay; Daniel H Moralejo; Kelly Kernan; Margaret Brzezinski; Jessica M Fuller; Randall W Barton; Ake Lernmark; William R A Osborne
Prolonged survival and improved glycemia in BioBreeding diabetic rats after early sustained exposure to glucagon-like peptide 1.
The journal of gene medicine 2010;12(6):538-44.
2010: Peter D Burbelo; Hiroki Hirai; Alexandra T Issa; Albert Kingman; Ake Lernmark; Sten-A Ivarsson; Abner L Notkins; Michael Iadarola
Comparison of radioimmunoprecipitation with luciferase immunoprecipitation for autoantibodies to GAD65 and IA-2beta.
Diabetes care 2010;33(4):754-6.
2010: Daniel H Moralejo; William Osborne; piper meigs treuting; Brian Van Yserloo; Jessica M Fuller; Carl T Hansen; Martin J Hessner; Richard Jensen; Anne E Kwitek; Ake Lernmark
Differential effects of leptin receptor mutation on male and female BBDR Gimap5-/Gimap5- spontaneously diabetic rats.
Physiological genomics 2010;41(1):9-20.
2010: Daria La Torre; Ake Lernmark
Immunology of beta-cell destruction.
Advances in experimental medicine and biology 2010;654():537-83.
2009: Shilpa Oak; Jared Radtke; Mona Landin-Olsson; Carina Törn; Ake Lernmark; Christiane S Hampe
Comparison of three assays for the detection of GAD65Ab-specific anti-idiotypic antibodies.
Journal of immunological methods 2009;351(1-2):55-61.
2009: Carl-David Agardh; K F Lynch; M Palmér; K Link; Ake Lernmark
GAD65 vaccination: 5 years of follow-up in a randomised dose-escalating study in adult-onset autoimmune diabetes.
Diabetologia 2009;52(7):1363-8.
2009: A Papadopoulou; K F Lynch; N Shaat; Anita Nilsson; Barbro Lernmark; Kerstin Berntorp; Sten-A Ivarsson; Carl-David Agardh; Ake Lernmark
The type 1 diabetes protective HLA DQB1*0602 allele is less frequent in gestational diabetes mellitus.
Diabetologia 2009;52(7):1339-42.
2009: J M Fuller; M Bogdani; T D Tupling; R A Jensen; R Pefley; S Manavi; L Cort; Elizabeth Blankenhorn; J P Mordes; Ake Lernmark; A E Kwitek
Genetic dissection reveals diabetes loci proximal to the gimap5 lymphopenia gene.
Physiological genomics 2009;38(1):89-97.
2009: John P Mordes; Laura Cort; Elaine Norowski; Jean Leif; Jessica M Fuller; Ake Lernmark; Dale L Greiner; Elizabeth Blankenhorn
Analysis of the rat Iddm14 diabetes susceptibility locus in multiple rat strains: identification of a susceptibility haplotype in the Tcrb-V locus.
Mammalian genome : official journal of the International Mammalian Genome Society 2009;20(3):162-9.
2009: Elizabeth A Rutledge; Jessica M Fuller; Brian Van Yserloo; Daniel H Moralejo; Ruth A Ettinger; Prashant Gaur; Jana L Hoehna; Morgan R Peterson; Richard Jensen; Anne E Kwitek; Ake Lernmark
Sequence variation and expression of the Gimap gene family in the BB rat.
Experimental diabetes research 2009;2009():835650.
2008: Ryan D Schulteis; Haiyan Chu; Xuezhi Dai; Yuhong Chen; Brandon Edwards; Dipica Haribhai; Calvin B Williams; Subramaniam Malarkannan; Martin J Hessner; Sanja Glisic; Srikanta Jana; Edward J Kerschen; Soumitra Ghosh; Demin Wang; Anne E Kwitek; Ake Lernmark; Jack Gorski; Hartmut Weiler
Impaired survival of peripheral T cells, disrupted NK/NKT cell development, and liver failure in mice lacking Gimap5.
Blood 2008;112(13):4905-14.
2008: Carani B Sanjeevi; Saikiran Sedimbi; Mona Landin-Olsson; Ingrid Kockum; Ake Lernmark
Risk conferred by HLA-DR and DQ for type 1 diabetes in 0-35-year age group in Sweden.
Annals of the New York Academy of Sciences 2008;1150():106-11.
2008: Ian R Sweet; Ofer Yanay; Lanaya Waldron; Merle Gilbert; Jessica M Fuller; Terry Tupling; Ake Lernmark; William R A Osborne
Treatment of diabetic rats with encapsulated islets.
Journal of cellular and molecular medicine 2008;12(6B):2644-50.
2008: H Elding Larsson; Gertie Hansson; A Carlsson; E Cederwall; B Jonsson; Bengt Jönsson; K Larsson; Kristian Lynch; J Neiderud; Ake Lernmark; Sten-A Ivarsson
Children developing type 1 diabetes before 6 years of age have increased linear growth independent of HLA genotypes.
Diabetologia 2008;51(9):1623-30.
2008: Peter D Burbelo; Hiroki Hirai; Hannah Leahy; Ake Lernmark; Sten-A Ivarsson; Michael Iadarola; Abner Louis Notkins
A new luminescence assay for autoantibodies to mammalian cell-prepared insulinoma-associated protein 2.
Diabetes care 2008;31(9):1824-6.
2008: Karin Larsson; Annelie Carlsson; Elisabeth Cederwall; Björn Jönsson; Jan Neiderud; Björn Jonsson; Ake Lernmark; Sten-A Ivarsson
Annual screening detects celiac disease in children with type 1 diabetes.
Pediatric diabetes 2008;9(4 Pt 2):354-9.
2008: L Akesson; R W Gelling; R Jensen; K Ogimoto; J M Fuller; R Pefley; S Manavi; Ake Lernmark; M W Schwartz
Increased lipid oxidation heralds diabetes onset in DR.lyp/lyp rats.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2008;116(8):475-80.
2008: Hiroki Hirai; Junnosuke Miura; Yafang Hu; Helena Larsson; Karin Larsson; Ake Lernmark; Sten-A Ivarsson; Tianxia Wu; Albert Kingman; Athanasios G Tzioufas; Abner Louis Notkins
Selective screening of secretory vesicle-associated proteins for autoantigens in type 1 diabetes: VAMP2 and NPY are new minor autoantigens.
Clinical immunology (Orlando, Fla.) 2008;127(3):366-74.
2008: Ramaswami Nalini; Lakshmi Gaur; Mario Maldonado; Christiane S Hampe; Lucille Rodriguez; Gilberto Garza; Ake Lernmark; Ashok Balasubramanyam
HLA class II alleles specify phenotypes of ketosis-prone diabetes.
Diabetes care 2008;31(6):1195-200.
2008: Jordan Steed; Lisa K Gilliam; Robert A Harris; Ake Lernmark; Christiane S Hampe
Antigen presentation of detergent-free glutamate decarboxylase (GAD65) is affected by human serum albumin as carrier protein.
Journal of immunological methods 2008;334(1-2):114-21.
2008: Sten-A Ivarsson; Ake Lernmark
Comment on: Edghill et al. (2008) Insulin mutation screening in 1,044 patients with diabetes: mutations in the INS gene are a common cause of neonatal diabetes but a rare cause of diabetes diagnosed in childhood or adulthood: Diabetes 57:1034-1042, 2008.
Diabetes 2008;57(5):e9.
2008: Michal Odermarsky; Ake Lernmark; Lennart Truedsson; Petru Liuba
Cutaneous microvascular dysfunction is associated with human leukocyte antigen-DQ in youths with type 1 diabetes.
Pediatric research 2008;63(4):420-2.
2008: Maria Elfving; Bengt Lindberg; Kristian Lynch; Majvi Månsson; Göran Sundkvist; Ake Lernmark; Sten-A Ivarsson
Number of islet autoantibodies present in newly diagnosed type 1 diabetes children born to non-diabetic mothers is affected by islet autoantibodies present at birth.
Pediatric diabetes 2008;9(2):127-34.
2008: K F Lynch; Barbro Lernmark; Juan Merlo; Corrado M Cilio; Sten-A Ivarsson; Ake Lernmark
Cord blood islet autoantibodies and seasonal association with the type 1 diabetes high-risk genotype.
Journal of perinatology : official journal of the California Perinatal Association 2008;28(3):211-7.
2008: Raivo Uibo; Ake Lernmark
GAD65 autoimmunity-clinical studies.
Advances in immunology 2008;100():39-78.
2008: Kobra Rahmati; Ake Lernmark; Charlotte Becker; Anna Foltyn-Zadura; Karin Larsson; Sten-Anders Ivarsson; Carina Törn
A comparison of serum and EDTA plasma in the measurement of glutamic acid decarboxylase autoantibodies (GADA) and autoantibodies to islet antigen-2 (IA-2A) using the RSR radioimmunoassay (RIA) and enzyme linked immunosorbent assay (ELISA) kits.
Clinical laboratory 2008;54(7-8):227-35.
2008: Maria Elfving; Johan Svensson; Sami Oikarinen; Björn Jonsson; Per Olofsson; Göran Sundkvist; Bengt Lindberg; Ake Lernmark; Heikki Hyöty; Sten-A Ivarsson
Maternal enterovirus infection during pregnancy as a risk factor in offspring diagnosed with type 1 diabetes between 15 and 30 years of age.
Experimental diabetes research 2008;2008():271958.
2007: S Asad; S Fawwaz; P Nikamo; Carina Törn; Mona Landin-Olsson; Ake Lernmark; M Alarcón-Riquelme; Ingrid Kockum
No evidence of association of the PDCD1 gene with Type 1 diabetes.
Diabetic medicine : a journal of the British Diabetic Association 2007;24(12):1473-7.
2007: M Elfving; Bengt Lindberg; K Lynch; S-A Ivarsson; Ake Lernmark; Christiane S Hampe
Epitope analysis of GAD65 binding in both cord blood and at the time of clinical diagnosis of childhood type 1 diabetes.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2007;39(11):790-6.
2007: Stefanie Eising; Jannet Svensson; Kristin Skogstrand; Anita Nilsson; Kristian Lynch; Paal Skytt Andersen; Ake Lernmark; David M Hougaard; Flemming Pociot; Bent Nørgaard-Pedersen; Jørn Nerup
Type 1 diabetes risk analysis on dried blood spot samples from population-based newborns: design and feasibility of an unselected case-control study.
Paediatric and perinatal epidemiology 2007;21(6):507-17.
2007: Michal Odermarsky; Anita Nilsson; Ake Lernmark; Sture Sjöblad; Petru Liuba
Atherogenic vascular and lipid phenotypes in young patients with Type 1 diabetes are associated with diabetes high-risk HLA genotype.
American journal of physiology. Heart and circulatory physiology 2007;293(5):H3175-9.
2007: R Jensen; Lisa K Gilliam; C Torn; Mona Landin-Olsson; Jerry Palmer; Karin Akesson; Ingrid Kockum; Barbro Lernmark; A F Karlsson; K F Lynch; Norman E Breslow; Ake Lernmark; Göran Sundkvist
Islet cell autoantibody levels after the diagnosis of young adult diabetic patients.
Diabetic medicine : a journal of the British Diabetic Association 2007;24(11):1221-8.
2007: Vinod Sommandas; Elizabeth A Rutledge; Brian Van Yserloo; Jessica Fuller; Ake Lernmark; Hemmo Drexhage
Low-density cells isolated from the rat thymus resemble branched cortical macrophages and have a reduced capability of rescuing double-positive thymocytes from apoptosis in the BB-DP rat.
Journal of leukocyte biology 2007;82(4):869-76.
2007: Lina Akesson; Tyson Hawkins; Richard Jensen; Jessica M Fuller; Norman E Breslow; Ake Lernmark
Decreased core temperature and increased beta(3)-adrenergic sensitivity in diabetes-prone BB rats.
Diabetes technology & therapeutics 2007;9(4):354-62.
2007: Carl-Oscar Jonson; Ake Lernmark; Johnny Ludvigsson; Elizabeth A Rutledge; Ari E Hinkkanen; Maria Karlsson Faresjö
The importance of CTLA-4 polymorphism and human leukocyte antigen genotype for the induction of diabetes-associated cytokine response in healthy school children.
Pediatric diabetes 2007;8(4):185-92.
2007: Richard A Jensen; Lisa K Gilliam; Carina Törn; Mona Landin-Olsson; F Anders Karlsson; Jerry P Palmer; Ingrid Kockum; Karin Akesson; Barbro Lernmark; Kristian Lynch; Norman E Breslow; Ake Lernmark
Multiple factors affect the loss of measurable C-peptide over 6 years in newly diagnosed 15- to 35-year-old diabetic subjects.
Journal of diabetes and its complications 2007;21(4):205-13.
2007: Bo Niklasson; T Hultman; René Kallies; Matthias Niedrig; R Nilsson; Per-Olof Berggren; Lisa Juntti-Berggren; Suad Efendic; Ake Lernmark; William Klitz
The BioBreeding rat diabetes model is infected with Ljungan virus.
Diabetologia 2007;50(7):1559-60.
2007: H E Larsson; Kristian Lynch; Barbro Lernmark; Gertie Hansson; Ake Lernmark; Sten-A Ivarsson
Relationship between increased relative birthweight and infections during pregnancy in children with a high-risk diabetes HLA genotype.
Diabetologia 2007;50(6):1161-9.
2007: Lynn Bekris; Richard A Jensen; E Lagerquist; Tyler R Hall; Carl-David Agardh; Corrado M Cilio; A L Lethagen; Ake Lernmark; J A Robertson; Christiane S Hampe
GAD65 autoantibody epitopes in adult patients with latent autoimmune diabetes following GAD65 vaccination.
Diabetic medicine : a journal of the British Diabetic Association 2007;24(5):521-6.
2007: N Shaat; Ake Lernmark; E Karlsson; Sten-A Ivarsson; Hemang Parikh; Kerstin Berntorp; Leif Groop
A variant in the transcription factor 7-like 2 (TCF7L2) gene is associated with an increased risk of gestational diabetes mellitus.
Diabetologia 2007;50(5):972-9.
2007: Lynn Bekris; Cynthia A Shephard; Marta Janer; Jinko Graham; B McNeney; J Shin; Marjan Zarghami; W Griffith; Federico M Farin; Terrance J Kavanagh; Ake Lernmark
Glutamate cysteine ligase catalytic subunit promoter polymorphisms and associations with type 1 diabetes age-at-onset and GAD65 autoantibody levels.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2007;115(4):221-8.
2007: Robert D Hoeldtke; Christiane S Hampe; Lynn Bekris; Gerald R Hobbs; Kimberly D Bryner; Ake Lernmark
Antibodies to GAD65 and peripheral nerve function in the DCCT.
Journal of neuroimmunology 2007;185(1-2):182-9.
2007: Mao Rui; Christiane S Hampe; Chen Wang; Zhidong Ling; Frans K Gorus; Ake Lernmark; Daniel G Pipeleers; Pieter De Pauw
Species and epitope specificity of two 65 kDa glutamate decarboxylase time-resolved fluorometric immunoassays.
Journal of immunological methods 2007;319(1-2):133-43.
2007: Antti-Pekka Laine; Hanna Holmberg; Anita Nilsson; Eva Ortqvist; Minna Kiviniemi; Outi Vaarala; Hans K Akerblom; Olli Simell; Mikael Knip; Johnny Ludvigsson; Sten-A Ivarsson; Karin Larsson; Ake Lernmark; Jorma Ilonen
Two insulin gene single nucleotide polymorphisms associated with type 1 diabetes risk in the Finnish and Swedish populations.
Disease markers 2007;23(3):139-45.
2006: Jessica M Fuller; Anne E Kwitek; Tyson Hawkins; Daniel H Moralejo; Wen Lu; Terry D Tupling; Armand J MacMurray; Gretta Borchardt; Michael Hasinoff; Ake Lernmark
Introgression of F344 rat genomic DNA on BB rat chromosome 4 generates diabetes-resistant lymphopenic BB rats.
Diabetes 2006;55(12):3351-7.
2006: Ashok Balasubramanyam; Gilberto Garza; Lucille Rodriguez; Christiane S Hampe; Lakshmi Gaur; Ake Lernmark; Mario R Maldonado
Accuracy and predictive value of classification schemes for ketosis-prone diabetes.
Diabetes care 2006;29(12):2575-9.
2006: B C Holm; J Svensson; C Akesson; J Arvastsson; J Ljungberg; Kristian Lynch; Sten-A Ivarsson; Ake Lernmark; Corrado M Cilio
Evidence for immunological priming and increased frequency of CD4+ CD25+ cord blood T cells in children born to mothers with type 1 diabetes.
Clinical and experimental immunology 2006;146(3):493-502.
2006: john gebe; Kellee A Unrath; Ben A Falk; Kouichi Ito; Li Wen; Terri L Daniels; Ake Lernmark; Gerald Nepom
Age-dependent loss of tolerance to an immunodominant epitope of glutamic acid decarboxylase in diabetic-prone RIP-B7/DR4 mice.
Clinical immunology (Orlando, Fla.) 2006;121(3):294-304.
2006: Rhonda Geoffrey; Shuang Jia; Anne E Kwitek; Jeffrey Woodliff; Soumitra Ghosh; Ake Lernmark; Xujing Wang; Martin J Hessner
Evidence of a functional role for mast cells in the development of type 1 diabetes mellitus in the BioBreeding rat.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(10):7275-86.
2006: Barbro Lernmark; Kristian Lynch; Ake Lernmark
Cord blood islet autoantibodies are related to stress in the mother during pregnancy.
Annals of the New York Academy of Sciences 2006;1079():345-9.
2006: William Hagopian; Ake Lernmark; Marian Rewers; Olli G Simell; Jin-Xiong She; Anette-G Ziegler; Jeffrey P Krischer; Beena Akolkar
TEDDY--The Environmental Determinants of Diabetes in the Young: an observational clinical trial.
Annals of the New York Academy of Sciences 2006;1079():320-6.
2006: Manu Gupta; Jinko Graham; Brian McNeeny; Marjan Zarghami; Mona Landin-Olsson; William Hagopian; Jerry Palmer; Ake Lernmark; Carani B Sanjeevi
MHC class I chain-related gene-A is associated with IA2 and IAA but not GAD in Swedish type 1 diabetes mellitus.
Annals of the New York Academy of Sciences 2006;1079():229-39.
2006: Jared C Roach; Kerry Deutsch; Sarah Li; Andrew F Siegel; Lynn Bekris; Derek C Einhaus; Colleen M Sheridan; Gustavo Glusman; Leroy Hood; Ake Lernmark; Marta Janer
Genetic mapping at 3-kilobase resolution reveals inositol 1,4,5-triphosphate receptor 3 as a risk factor for type 1 diabetes in Sweden.
American journal of human genetics 2006;79(4):614-27.
2006: Bo Niklasson; Annika Samsioe; M Blixt; Stellan Sandler; Ake Sjöholm; E Lagerquist; Ake Lernmark; William Klitz
Prenatal viral exposure followed by adult stress produces glucose intolerance in a mouse model.
Diabetologia 2006;49(9):2192-9.
2006: Farhad Zangeneh; Puneet S Arora; Peter J Dyck; Lynn Bekris; Ake Lernmark; Sara J Achenbach; Ann L Oberg; Robert A Rizza
Effects of duration of type 2 diabetes mellitus on insulin secretion.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 2006;12(4):388-93.
2006: N Shaat; E Karlsson; Ake Lernmark; Sten-A Ivarsson; K Lynch; Hemang Parikh; Peter Almgren; Kerstin Berntorp; Leif Groop
Common variants in MODY genes increase the risk of gestational diabetes mellitus.
Diabetologia 2006;49(7):1545-51.
2006: Daniel Agardh; Kristian Lynch; C Brundin; Sten-A Ivarsson; Ake Lernmark; Corrado M Cilio
Reduction of tissue transglutaminase autoantibody levels by gluten-free diet is associated with changes in subsets of peripheral blood lymphocytes in children with newly diagnosed coeliac disease.
Clinical and experimental immunology 2006;144(1):67-75.
2006: Lynn Bekris; Terrance J Kavanagh; Ake Lernmark
Targeting type 1 diabetes before and at the clinical onset of disease.
Endocrine, metabolic & immune disorders drug targets 2006;6(1):103-24.
2005: Lynn Bekris; Cynthia A Shephard; Morgan Peterson; Jana Hoehna; Brian Van Yserloo; Elizabeth Rutledge; Federico M Farin; Terrance J Kavanagh; Ake Lernmark
Glutathione-s-transferase M1 and T1 polymorphisms and associations with type 1 diabetes age-at-onset.
Autoimmunity 2005;38(8):567-75.
2005: N Shaat; Magnus Ekelund; Ake Lernmark; Sten-A Ivarsson; Peter Almgren; Kerstin Berntorp; Leif Groop
Association of the E23K polymorphism in the KCNJ11 gene with gestational diabetes mellitus.
Diabetologia 2005;48(12):2544-51.
2005: AM Valdes; Glenys Thomson; Jinko Graham; Marjan Zarghami; B McNeney; Ingrid Kockum; A Smith; M Lathrop; Ann R Steenkiste; Janice S Dorman; Janelle A Noble; J A Hansen; Alberto Pugliese; Ake Lernmark
D6S265*15 marks a DRB1*15, DQB1*0602 haplotype associated with attenuated protection from type 1 diabetes mellitus.
Diabetologia 2005;48(12):2540-3.
2005: Catherine Pihoker; Lisa K Gilliam; Christiane S Hampe; Ake Lernmark
Autoantibodies in diabetes.
Diabetes 2005;54 Suppl 2():S52-61.
2005: Tyson Hawkins; Jessica Fuller; Kara Olson; Sara J Speros; Ake Lernmark
DR.lyp/lyp bone marrow maintains lymphopenia and promotes diabetes in lyp/lyp but not in +/+ recipient DR.lyp BB rats.
Journal of autoimmunity 2005;25(4):251-7.
2005: Karin Akesson; Lennarth Nyström; L Färnkvist; Jan Ostman; Ake Lernmark; Ingrid Kockum
Increased risk of diabetes among relatives of female insulin-treated patients diagnosed at 15-34 years of age.
Diabetic medicine : a journal of the British Diabetic Association 2005;22(11):1551-7.
2005: Ake Lernmark; Carl-David Agardh
Immunomodulation with human recombinant autoantigens.
Trends in immunology 2005;26(11):608-12.
2005: Torgny Stigbrand; Lars Rymo; Ake Lernmark
[The Medical Biobank--a unique resource for medical research].
Läkartidningen 2005;102(39):2769-72.
2005: Daniel Agardh; Ingrid Dahlbom; Terri Daniels; Ester Lörinc; Sten-A Ivarsson; Ake Lernmark; Tony Hansson
Autoantibodies against soluble and immobilized human recombinant tissue transglutaminase in children with celiac disease.
Journal of pediatric gastroenterology and nutrition 2005;41(3):322-7.
2005: Vinod Sommandas; Elizabeth A Rutledge; Brian Van Yserloo; Jessica Fuller; Ake Lernmark; Hemmo Drexhage
Aberrancies in the differentiation and maturation of dendritic cells from bone-marrow precursors are linked to various genes on chromosome 4 and other chromosomes of the BB-DP rat.
Journal of autoimmunity 2005;25(1):1-12.
2005: H E Larsson; Kristian Lynch; Barbro Lernmark; Anita Nilsson; Gertie Hansson; Peter Almgren; Ake Lernmark; Sten-A Ivarsson
Diabetes-associated HLA genotypes affect birthweight in the general population.
Diabetologia 2005;48(8):1484-91.
2005: Daniel Agardh; Bodil Roth; Ake Lernmark; Pål Stenberg
Calcium activation of tissue transglutaminase in radioligand binding and enzyme-linked autoantibody immunoassays in childhood celiac disease.
Clinica chimica acta; international journal of clinical chemistry 2005;358(1-2):95-103.
2005: Vinod Sommandas; Elizabeth A Rutledge; Brian Van Yserloo; Jessica Fuller; Ake Lernmark; Hemmo Drexhage
Defects in differentiation of bone-marrow derived dendritic cells of the BB rat are partly associated with IDDM2 (the lyp gene) and partly associated with other genes in the BB rat background.
Journal of autoimmunity 2005;25(1):46-56.
2005: Carl-David Agardh; Corrado M Cilio; AsaLinda Lethagen; Kristian Lynch; richard leslie; Mats Palmér; Robert A Harris; John A Robertson; Ake Lernmark
Clinical evidence for the safety of GAD65 immunomodulation in adult-onset autoimmune diabetes.
Journal of diabetes and its complications 2005;19(4):238-46.
2005: Ake Lernmark
Type 1 diabetes--does suppressing T cells increase insulin?
The New England journal of medicine 2005;352(25):2642-4.
2005: Carolyn Padoa; Nigel J Crowther; J W Thomas; Tyler R Hall; Lynn Bekris; C Torn; Mona Landin-Olsson; Eva Ortqvist; Jerry P Palmer; Ake Lernmark; Christiane S Hampe
Epitope analysis of insulin autoantibodies using recombinant Fab.
Clinical and experimental immunology 2005;140(3):564-71.
2004: Martin J Hessner; Xujing Wang; Lisa Meyer; Rhonda Geoffrey; Shuang Jia; Jessica Fuller; Ake Lernmark; Soumitra Ghosh
Involvement of eotaxin, eosinophils, and pancreatic predisposition in development of type 1 diabetes mellitus in the BioBreeding rat.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(11):6993-7002.
2004: Mario Maioli; Emilyn Alejandro; Giancarlo Tonolo; Lisa K Gilliam; Lynn Bekris; Christiane S Hampe; Domenica A Obinu; Alberto Manconi; Loreta Puddu; Kristian Lynch; Ake Lernmark
Epitope-restricted 65-kilodalton glutamic acid decarboxylase autoantibodies among new-onset Sardinian type 2 diabetes patients define phenotypes of autoimmune diabetes.
The Journal of clinical endocrinology and metabolism 2004;89(11):5675-82.
2004: Karin Larsson; Helena Elding-Larsson; Elisabeth Cederwall; Karin Kockum; Jan Neiderud; Sture Sjöblad; Bengt Lindberg; Barbro Lernmark; Corrado M Cilio; Sten-A Ivarsson; Ake Lernmark
Genetic and perinatal factors as risk for childhood type 1 diabetes.
Diabetes/metabolism research and reviews 2004;20(6):429-37.
2004: Mieczyslaw Michalkiewicz; Teresa Michalkiewicz; Ruth A Ettinger; Elizabeth A Rutledge; Jessica M Fuller; Daniel H Moralejo; Brian Van Yserloo; Armand J MacMurray; Anne E Kwitek; Howard J Jacob; Eric S Lander; Ake Lernmark
Transgenic rescue demonstrates involvement of the Ian5 gene in T cell development in the rat.
Physiological genomics 2004;19(2):228-32.
2004: Ian R Sweet; Daniel L Cook; Ake Lernmark; Carla J Greenbaum; Kenneth A Krohn
Non-invasive imaging of beta cell mass: a quantitative analysis.
Diabetes technology & therapeutics 2004;6(5):652-9.
2004: Roos C Padmos; Lynn Bekris; Esther M Knijff; Henning Tiemeier; Ralph W Kupka; Dan Cohen; Willem A Nolen; Ake Lernmark; Hemmo Drexhage
A high prevalence of organ-specific autoimmunity in patients with bipolar disorder.
Biological psychiatry 2004;56(7):476-82.
2004: Dong Luo; Lisa K Gilliam; Carla J Greenbaum; Lynn Bekris; Christiane S Hampe; Terri Daniels; W Richter; Santica M Marcovina; Olov Rolandsson; Mona Landin-Olsson; Ingrid Kockum; Ake Lernmark
Conformation-dependent GAD65 autoantibodies in diabetes.
Diabetologia 2004;47(9):1581-91.
2004: Dong Luo; Chad N Rogers; Jordan T Steed; Lisa K Gilliam; Christiane S Hampe; Ake Lernmark
Development of glutamic acid decarboxylase 65 (GAD65) autoantibody assay using biotin-GAD65 fusion protein.
Journal of biotechnology 2004;111(1):97-104.
2004: Ake Lernmark
Type 1 diabetes as a model for prediction and diagnosis.
Autoimmunity 2004;37(4):341-5.
2004: N Shaat; Magnus Ekelund; Ake Lernmark; Sten-A Ivarsson; Anita Nilsson; R Perfekt; Kerstin Berntorp; Leif Groop
Genotypic and phenotypic differences between Arabian and Scandinavian women with gestational diabetes mellitus.
Diabetologia 2004;47(5):878-84.
2004: Ian R Sweet; Daniel L Cook; Ake Lernmark; Carla J Greenbaum; Angela R Wallen; Erin S Marcum; Svetlana A Stekhova; Kenneth A Krohn
Systematic screening of potential beta-cell imaging agents.
Biochemical and biophysical research communications 2004;314(4):976-83.
2004: Elisabet Agardh; Lakshmi K Gaur; Ake Lernmark; Carl-David Agardh
HLA-DRB1, -DQA1, and -DQB1 subtypes or ACE gene polymorphisms do not seem to be risk markers for severe retinopathy in younger Type 1 diabetic patients.
Journal of diabetes and its complications 2004;18(1):32-6.
2003: Philippe Boutin; Christian Dina; Francis Vasseur; Séverine Dubois; Laetitia Corset; Karin Séron; Lynn Bekris; Janice Cabellon; Bernadette Neve; Valérie Vasseur-Delannoy; Mohamed Chikri; Marie-Aline Charles; Karine Clement; Ake Lernmark; philippe froguel
GAD2 on chromosome 10p12 is a candidate gene for human obesity.
PLoS biology 2003;1(3):E68.
2003: Daniel H Moralejo; Hyunhee A Park; Sara J Speros; Armand J MacMurray; Anne E Kwitek; Howard J Jacob; Eric S Lander; Ake Lernmark
Genetic dissection of lymphopenia from autoimmunity by introgression of mutated Ian5 gene onto the F344 rat.
Journal of autoimmunity 2003;21(4):315-24.
2003: Bo Niklasson; Birger Hörnfeldt; Erik Nyholm; Matthias Niedrig; Oliver Donoso Mantke; Hans R Gelderblom; Ake Lernmark
Type 1 diabetes in Swedish bank voles (Clethrionomys glareolus): signs of disease in both colonized and wild cyclic populations at peak density.
Annals of the New York Academy of Sciences 2003;1005():170-5.
2003: Mario Maldonado; Christiane S Hampe; Lakshmi Gaur; Susana D'Amico; Dinakar Iyer; Lisa P Hammerle; Douglas Bolgiano; Lucille Rodriguez; Arun Rajan; Ake Lernmark; Ashok Balasubramanyam
Ketosis-prone diabetes: dissection of a heterogeneous syndrome using an immunogenetic and beta-cell functional classification, prospective analysis, and clinical outcomes.
The Journal of clinical endocrinology and metabolism 2003;88(11):5090-8.
2003: Saul Genuth; K G M M Alberti; Peter Bennett; John B Buse; Ralph DeFronzo; Richard Kahn; John Kitzmiller; William C Knowler; Harold E Lebovitz; Ake Lernmark; David Nathan; Jerry Palmer; Robert A Rizza; Christopher D Saudek; Jonathan Shaw; Michael Steffes; Michael P Stern; Jaako Tuomilehto; Paul Zimmet
Follow-up report on the diagnosis of diabetes mellitus.
Diabetes care 2003;26(11):3160-7.
2003: Thomas O Mundinger; Qi Mei; Dianne P Figlewicz; Ake Lernmark; Gerald J Taborsky
Impaired glucagon response to sympathetic nerve stimulation in the BB diabetic rat: effect of early sympathetic islet neuropathy.
American journal of physiology. Endocrinology and metabolism 2003;285(5):E1047-54.
2003: Tetsuro Kobayashi; Shoichiro Tanaka; Minoru Okubo; Koji Nakanishi; Toshio Murase; Ake Lernmark
Unique epitopes of glutamic acid decarboxylase autoantibodies in slowly progressive type 1 diabetes.
The Journal of clinical endocrinology and metabolism 2003;88(10):4768-75.
2003: Andrea D Carroll; Louis Scampavia; Dong Luo; Ake Lernmark; Jaromir Ruzicka
Bead injection ELISA for the determination of antibodies implicated in type 1 diabetes mellitus.
The Analyst 2003;128(9):1157-62.
2003: Dong Luo; Chad N Rogers; Christiane S Hampe; Ake Lernmark
Molecular engineering of biotin-glutamic acid decarboxylase 65 fusion protein (Biotin-GAD65) for non-radioactive GAD65 antibody assay.
Journal of biotechnology 2003;103(3):249-55.
2003: A Maria Elfving; Bengt Lindberg; Lennarth Nyström; Göran Sundkvist; Ake Lernmark; Sten-A Ivarsson
Islet autoantibodies in cord blood from patients who developed type 1 diabetes mellitus at 15-30 years of age.
Autoimmunity 2003;36(4):227-31.
2003: Manu Gupta; Liene Nikitina-Zake; Marjan Zarghami; Mona Landin-Olsson; Ingrid Kockum; Ake Lernmark; Carani B Sanjeevi
Association between the transmembrane region polymorphism of MHC class I chain related gene-A and type 1 diabetes mellitus in Sweden.
Human immunology 2003;64(5):553-61.
2003: Olov Rolandsson; Erik Hägg; M Janer; E Rutledge; L K Gaur; M Nilsson; Göran Hallmans; Ake Lernmark
High GAD65 autoantibody levels in nondiabetic adults are associated with HLA but not with CTLA-4 or INS VNTR.
Journal of internal medicine 2003;253(4):447-53.
2003: A Maria Elfving; Bengt Lindberg; Mona Landin-Olsson; Christiane S Hampe; Ake Lernmark; Sten-A Ivarsson
Islet cell autoantibodies in cord blood from children with blood group incompatibility or hyperbilirubinemia.
Autoimmunity 2003;36(2):111-5.
2003: Bo Niklasson; Knud E Heller; Bryan Schønecker; Mogens Bildsøe; Terri Daniels; Christiane S Hampe; Per Olov Widlund; William T Simonson; Jonathan B Schaefer; Elizabeth Rutledge; Lynn Bekris; A Michael Lindberg; Susanne Johansson; Eva Ortqvist; Bengt Persson; Ake Lernmark
Development of type 1 diabetes in wild bank voles associated with islet autoantibodies and the novel ljungan virus.
International journal of experimental diabesity research 2003;4(1):35-44.
2003: Daniel Agardh; Stefan Borulf; Ake Lernmark; Sten-A Ivarsson
Tissue transglutaminase immunoglobulin isotypes in children with untreated and treated celiac disease.
Journal of pediatric gastroenterology and nutrition 2003;36(1):77-82.
2002: Annette Plesner; Carla J Greenbaum; Lakshmi K Gaur; Robert Ernst; Ake Lernmark
Macrophages from high-risk HLA-DQB1*0201/*0302 type 1 diabetes mellitus patients are hypersensitive to lipopolysaccharide stimulation.
Scandinavian journal of immunology 2002;56(5):522-9.
2002: Qi Mei; Thomas O Mundinger; Ake Lernmark; Gerald J Taborsky
Early, selective, and marked loss of sympathetic nerves from the islets of BioBreeder diabetic rats.
Diabetes 2002;51(10):2997-3002.
2002: Christiane S Hampe; Ingrid Kockum; Mona Landin-Olsson; Carina Törn; Eva Ortqvist; Bengt Persson; Olov Rolandsson; Jerry Palmer; Ake Lernmark
GAD65 antibody epitope patterns of type 1.5 diabetic patients are consistent with slow-onset autoimmune diabetes.
Diabetes care 2002;25(8):1481-2.
2002: Olov Rolandsson; Michael F Haney; E Hagg; Björn Biber; Ake Lernmark
Streptozotocin induced diabetes in minipig: a case report of a possible model for type 1 diabetes?
Autoimmunity 2002;35(4):261-4.
2002: Armand J MacMurray; Daniel H Moralejo; Anne E Kwitek; Elizabeth A Rutledge; Brian Van Yserloo; Paul Gohlke; Sara J Speros; Ben Snyder; Jonathan Schaefer; Sabine Bieg; Jianjie Jiang; Ruth A Ettinger; Jessica Fuller; Terri L Daniels; Anna Pettersson; Kimberly Orlebeke; Bruce Birren; Howard J Jacob; Eric S Lander; Ake Lernmark
Lymphopenia in the BB rat model of type 1 diabetes is due to a mutation in a novel immune-associated nucleotide (Ian)-related gene.
Genome research 2002;12(7):1029-39.
2002: Tom J Sims; Ake Lernmark; Lloyd Mancl; Robert E Schifferle; Roy C Page; Rutger Persson
Serum IgG to heat shock proteins and Porphyromonas gingivalis antigens in diabetic patients with periodontitis.
Journal of clinical periodontology 2002;29(6):551-62.
2002: William T Simonson; Sheela Ramanathan; Sabine Bieg; Philippe Poussier; Ake Lernmark
Protein-free diets do not protect high-incidence diabetes-prone BioBreeding rats from diabetes.
Metabolism: clinical and experimental 2002;51(5):569-74.
2002: Jinko Graham; William Hagopian; Ingrid Kockum; Lou Sheng Li; Carani B Sanjeevi; Robert M Lowe; Jonathan B Schaefer; Marjan Zarghami; Heather L Day; Mona Landin-Olsson; Jerry P Palmer; Marta Janer-Villanueva; Leroy Hood; Göran Sundkvist; Ake Lernmark; Norman E Breslow; Gisela Dahlquist; Göran Blohmé
Genetic effects on age-dependent onset and islet cell autoantibody markers in type 1 diabetes.
Diabetes 2002;51(5):1346-55.
2002: Ake Lernmark
Multiple sclerosis and type 1 diabetes: an unlikely alliance.
Lancet 2002;359(9316):1450-1.
2002: Carani B Sanjeevi; Mona Landin-Olsson; Ingrid Kockum; G Dahlquist; Ake Lernmark
The combination of several polymorphic amino acid residues in the DQalpha and DQbeta chains forms a domain structure pattern and is associated with insulin-dependent diabetes mellitus.
Annals of the New York Academy of Sciences 2002;958():362-75.
2002: Ake Lernmark
Controlling the controls: GAD65 autoreactive T cells in type 1 diabetes.
The Journal of clinical investigation 2002;109(7):869-70.
2002: Mario Maioli; Giancarlo Tonolo; Lynn Bekris; R Cirillo; DB Schranz; E Cossu; Milco Ciccarese; Ake Lernmark
GAD65 and IA-2 autoantibodies are common in a subset of siblings of Sardinian Type 2 diabetes families.
Diabetes research and clinical practice 2002;56(1):41-7.
2002: Leila Clark; Carla J Greenbaum; Jianjie Jiang; Ake Lernmark; Hans D Ochs
The antibody response to bacteriophage is linked to the lymphopenia gene in congenic BioBreeding rats.
FEMS immunology and medical microbiology 2002;32(3):205-9.
2002: Justin Mohatt; Lisa K Gilliam; Lynn Bekris; Sven Ebbesson; Ake Lernmark
Type 1 diabetes-related autoantibodies are rare in Alaska native populations.
International journal of circumpolar health 2002;61(1):21-31.
2002: Christiane S Hampe; Lisa P Hammerle; Lynn Bekris; Eva Ortqvist; Bengt Persson; Ake Lernmark
Stable GAD65 autoantibody epitope patterns in type 1 diabetes children five years after onset.
Journal of autoimmunity 2002;18(1):49-53.
2002: Ian R Sweet; Daniel L Cook; Robert Wiseman; Carla J Greenbaum; Ake Lernmark; Shinichi Matsumoto; Jeanette C Teague; Kenneth A Krohn
Dynamic perifusion to maintain and assess isolated pancreatic islets.
Diabetes technology & therapeutics 2002;4(1):67-76.
2002: Daniel Agardh; A Nilsson; Annelie Carlsson; Ingrid Kockum; Ake Lernmark; Sten-A Ivarsson
Tissue transglutaminase autoantibodies and human leucocyte antigen in Down's syndrome patients with coeliac disease.
Acta paediatrica (Oslo, Norway : 1992) 2002;91(1):34-8.
2001: Daniel Agardh; A Nilsson; T Tuomi; Bengt Lindberg; Annelie K Carlsson; Ake Lernmark; Sten-A Ivarsson
Prediction of silent celiac disease at diagnosis of childhood type 1 diabetes by tissue transglutaminase autoantibodies and HLA.
Pediatric diabetes 2001;2(2):58-65.
2001: Tom J Sims; Ake Lernmark; T Smith; Roy C Page; Rutger Persson
Treatment outcome for IDDM patients in relation to glutamic acid decarboxylase autoantibodies and serum IgG to periodontal pathogens.
Journal of clinical periodontology 2001;28(6):550-7.
2001: Olov Rolandsson; Erik Hägg; M Nilsson; Göran Hallmans; Lucia Mincheva-Nilsson; Ake Lernmark
Prediction of diabetes with body mass index, oral glucose tolerance test and islet cell autoantibodies in a regional population.
Journal of internal medicine 2001;249(4):279-88.
2001: Annette Plesner; Carla J Greenbaum; Ake Lernmark
Low serum conditions for in vitro generation of human macrophages with macrophage colony stimulating factor.
Journal of immunological methods 2001;249(1-2):53-61.
2001: Christiane S Hampe; P Lundgren; Terri Daniels; Lisa P Hammerle; Santica M Marcovina; Ake Lernmark
A novel monoclonal antibody specific for the N-terminal end of GAD65.
Journal of neuroimmunology 2001;113(1):63-71.
2001: Christiane S Hampe; Lisa P Hammerle; A Falorni; J Robertson; Ake Lernmark
Site-directed mutagenesis of K396R of the 65 kDa glutamic acid decarboxylase active site obliterates enzyme activity but not antibody binding.
FEBS letters 2001;488(3):185-9.
2001: Annette Plesner; Christiane S Hampe; Terri Daniels; Lisa P Hammerle; Ake Lernmark
Preservation of enzyme activity and antigenicity after mutagenesis of the membrane anchoring domain of GAD65.
Autoimmunity 2001;34(4):221-30.
2001: Carina Törn; Mona Landin-Olsson; Ake Lernmark; Bengt Scherstén; Jan Ostman; Hans J Arnqvist; Erik Björk; Göran Blohmé; Jan Bolinder; J Eriksson; B Littorin; Lennarth Nyström; Göran Sundkvist
Combinations of beta cell specific autoantibodies at diagnosis of diabetes in young adults reflects different courses of beta cell damage.
Autoimmunity 2001;33(2):115-20.
2000: Christiane S Hampe; Lisa P Hammerle; Lynn Bekris; Eva Ortqvist; Ingrid Kockum; Olov Rolandsson; Mona Landin-Olsson; Carina Törn; Bengt Persson; Ake Lernmark
Recognition of glutamic acid decarboxylase (GAD) by autoantibodies from different GAD antibody-positive phenotypes.
The Journal of clinical endocrinology and metabolism 2000;85(12):4671-9.
2000: Carina Törn; Mona Landin-Olsson; Ake Lernmark; Jerry P Palmer; Hans J Arnqvist; Göran Blohmé; F Lithner; B Littorin; Lennarth Nyström; Bengt Scherstén; Göran Sundkvist; lars b wibell; Jan Ostman
Prognostic factors for the course of beta cell function in autoimmune diabetes.
The Journal of clinical endocrinology and metabolism 2000;85(12):4619-23.
2000: Carina Törn; Mona Landin-Olsson; Jan Ostman; Bengt Scherstén; Hans J Arnqvist; Göran Blohmé; Erik Björk; Jan Bolinder; J Eriksson; B Littorin; Lennarth Nyström; Göran Sundkvist; Ake Lernmark
Glutamic acid decarboxylase antibodies (GADA) is the most important factor for prediction of insulin therapy within 3 years in young adult diabetic patients not classified as Type 1 diabetes on clinical grounds.
Diabetes/metabolism research and reviews 2000;16(6):442-47.
2000: R M Lowe; Jinko Graham; GC Sund; Ingrid Kockum; Mona Landin-Olsson; Jonathan B Schaefer; Carina Törn; Ake Lernmark; Gisela Dahlquist
The length of the CTLA-4 microsatellite (AT)N-repeat affects the risk for type 1 diabetes. Diabetes Incidence in Sweden Study Group.
Autoimmunity 2000;32(3):173-80.
2000: Robert D Hoeldtke; Kimberly D Bryner; Gerald R Hobbs; GG Horvath; Jack E Riggs; Ian Christie; Gary Ganser; S M Marcovina; Ake Lernmark
Antibodies to glutamic acid decarboxylase and peripheral nerve function in type 1 diabetes.
The Journal of clinical endocrinology and metabolism 2000;85(9):3297-308.
2000: E J Novak; Eva Ortqvist; E Nord; L Edwall; Christiane S Hampe; Lynn Bekris; B E Persson; Ake Lernmark
Stability of disease-associated antibody titers in pregnant women with type 1 diabetes with or without residual beta-cell function.
Diabetes care 2000;23(7):1019-21.
2000: DB Schranz; Lynn Bekris; Mona Landin-Olsson; Carina Törn; A Niläng; A Toll; J Sjöström; H Grönlund; Ake Lernmark
Newly diagnosed latent autoimmune diabetes in adults (LADA) is associated with low level glutamate decarboxylase (GAD65) and IA-2 autoantibodies. Diabetes Incidence Study in Sweden (DISS).
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2000;32(4):133-8.
2000: Jan Ostman; Mona Landin-Olsson; Carina Törn; Jerry Palmer; Ake Lernmark; Hans J Arnqvist; Erik Björk; Jan Bolinder; Göran Blohmé; J Eriksson; B Littorin; Lennarth Nyström; Bengt Scherstén; Göran Sundkvist; lars b wibell
Ketoacidosis in young adults is not related to the islet antibodies at the diagnosis of Type 1 diabetes mellitus--a nationwide study.
Diabetic medicine : a journal of the British Diabetic Association 2000;17(4):269-74.
2000: Steven D Chessler; Ake Lernmark
Alternative splicing of GAD67 results in the synthesis of a third form of glutamic-acid decarboxylase in human islets and other non-neural tissues.
The Journal of biological chemistry 2000;275(7):5188-92.
2000: Santica M Marcovina; Mona Landin-Olsson; A Essen-Möller; Jerry P Palmer; Ake Lernmark
Evaluation of a novel radioimmunoassay using 125I-labelled human recombinant GAD65 for the determination of glutamic acid decarboxylase (GAD65) autoantibodies.
International journal of clinical & laboratory research 2000;30(1):21-6.
2000: Sabine Bieg; William T Simonson; K Ellefsen; Ake Lernmark
Rel B is an early marker of autoimmune islet inflammation in the biobreeding (BB) rat.
Pancreas 2000;20(1):47-54.
1999: W Hao; C Davis; Terri Daniels; Christiane S Hampe; Ake Lernmark
Epitope-specific glutamic acid decarboxylase-65 autoantibodies in intravenous immunoglobulin preparations.
Transfusion medicine (Oxford, England) 1999;9(4):307-10.
1999: Bengt Lindberg; Sten-A Ivarsson; Ake Lernmark
Islet autoantibodies in cord blood could be a risk factor for future diabetes.
Diabetologia 1999;42(11):1375.
1999: Christiane S Hampe; Eva Ortqvist; Bengt Persson; DB Schranz; Ake Lernmark
Glutamate decarboxylase (GAD) autoantibody epitope shift during the first year of type 1 diabetes.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1999;31(10):553-7.
1999: Ingrid Kockum; Carani B Sanjeevi; S Eastman; Mona Landin-Olsson; G Dahlquist; Ake Lernmark
Complex interaction between HLA DR and DQ in conferring risk for childhood type 1 diabetes.
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics 1999;26(5):361-72.
1999: Lindy S Klaff; G Koike; Jianjie Jiang; Y Wang; Sabine Bieg; Anna Pettersson; Eric S Lander; H Jacob; Ake Lernmark
BB rat diabetes susceptibility and body weight regulation genes colocalize on chromosome 2.
Mammalian genome : official journal of the International Mammalian Genome Society 1999;10(9):883-7.
1999: W Hao; C Davis; I B Hirsch; L J Eng; Terri Daniels; D Walsh; Ake Lernmark
Plasmapheresis and immunosuppression in stiff-man syndrome with type 1 diabetes: a 2-year study.
Journal of neurology 1999;246(8):731-5.
1999: Bengt Lindberg; K Ahlfors; Annelie Carlsson; Ulla-Britt Ericsson; Mona Landin-Olsson; Ake Lernmark; J Ludvigsson; Göran Sundkvist; Sten-A Ivarsson
Previous exposure to measles, mumps, and rubella--but not vaccination during adolescence--correlates to the prevalence of pancreatic and thyroid autoantibodies.
Pediatrics 1999;104(1):e12.
1999: Olov Rolandsson; Erik Hägg; Christiane S Hampe; E P Sullivan; M Nilsson; G Jansson; Göran Hallmans; Ake Lernmark
Glutamate decarboxylase (GAD65) and tyrosine phosphatase-like protein (IA-2) autoantibodies index in a regional population is related to glucose intolerance and body mass index.
Diabetologia 1999;42(5):555-9.
1999: Jinko Graham; Ingrid Kockum; Carani B Sanjeevi; Mona Landin-Olsson; Lennarth Nyström; Göran Sundkvist; Hans J Arnqvist; Göran Blohmé; F Lithner; B Littorin; Bengt Scherstén; lars b wibell; Jan Ostman; Ake Lernmark; Norman E Breslow; Gisela Dahlquist
Negative association between type 1 diabetes and HLA DQB1*0602-DQA1*0102 is attenuated with age at onset. Swedish Childhood Diabetes Study Group.
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics 1999;26(2-3):117-27.
1999: Ake Lernmark
[Vaccination against type 1 diabetes at the clinical trial stage].
Läkartidningen 1999;96(11):1300-2.
1999: B Littorin; Göran Sundkvist; William Hagopian; Mona Landin-Olsson; Ake Lernmark; Jan Ostman; Hans J Arnqvist; Göran Blohmé; Jan Bolinder; Jan W Eriksson; F Lithner; Bengt Scherstén; lars b wibell
Islet cell and glutamic acid decarboxylase antibodies present at diagnosis of diabetes predict the need for insulin treatment. A cohort study in young adults whose disease was initially labeled as type 2 or unclassifiable diabetes.
Diabetes care 1999;22(3):409-12.
1999: Bengt Lindberg; Sten-A Ivarsson; Mona Landin-Olsson; Göran Sundkvist; L Svanberg; Ake Lernmark
Islet autoantibodies in cord blood from children who developed type I (insulin-dependent) diabetes mellitus before 15 years of age.
Diabetologia 1999;42(2):181-7.
1999: Christiane S Hampe; Eva Ortqvist; Olov Rolandsson; Mona Landin-Olsson; Carina Törn; Asa Agren; Bengt Persson; DB Schranz; Ake Lernmark
Species-specific autoantibodies in type 1 diabetes.
The Journal of clinical endocrinology and metabolism 1999;84(2):643-8.
1999: W Hao; Terri Daniels; Daniel G Pipeleers; A Smismans; H Reijonen; Gerald Nepom; Ake Lernmark
Radioimmunoassay for glutamic acid decarboxylase-65.
Diabetes technology & therapeutics 1999;1(1):13-20.
1999: Bengt Lindberg; Annelie Carlsson; Ulla-Britt Ericsson; Ingrid Kockum; Ake Lernmark; Mona Landin-Olsson; Göran Sundkvist; Sten-A Ivarsson
Prevalence of beta-cell and thyroid autoantibody positivity in schoolchildren during three-year follow-up.
Autoimmunity 1999;31(3):175-85.
1999: Mona Landin-Olsson; Hans J Arnqvist; Göran Blohmé; B Littorin; F Lithner; Lennarth Nyström; Bengt Scherstén; Göran Sundkvist; lars b wibell; Jan Ostman; Ake Lernmark
Appearance of islet cell autoantibodies after clinical diagnosis of diabetes mellitus.
Autoimmunity 1999;29(1):57-63.
1999: E S Lee; Jianjie Jiang; GC Sund; William T Simonson; Jinko Graham; Gregory N Dietsch; B Schimpf; Sabine Bieg; G Peterman; Ake Lernmark
Recombinant human platelet-activating factor acetylhydrolase reduces the frequency of diabetes in the diabetes-prone BB rat.
Diabetes 1999;48(1):43-9.
1998: Daniel Agardh; Elisabet Agardh; Mona Landin-Olsson; Lakshmi K Gaur; Carl-David Agardh; Ake Lernmark
Inverse relationship between GAD65 antibody levels and severe retinopathy in younger type 1 diabetic patients.
Diabetes research and clinical practice 1998;40(1):9-14.
1998: DB Schranz; Lynn Bekris; Mona Landin-Olsson; Carina Törn; A Niläng; A Toll; H Grönlund; Bert Toivola; Ake Lernmark
A simple and rapid microSepharose assay for GAD65 and ICA512 autoantibodies in diabetes. Diabetes Incidence Study in Sweden (DISS).
Journal of immunological methods 1998;213(1):87-97.
1998: Sabine Bieg; G Koike; Jianjie Jiang; Lindy S Klaff; Anna Pettersson; Armand J MacMurray; Howard J Jacob; Eric S Lander; Ake Lernmark
Genetic isolation of iddm 1 on chromosome 4 in the biobreeding (BB) rat.
Mammalian genome : official journal of the International Mammalian Genome Society 1998;9(4):324-6.
1998: D B Schranz; Ake Lernmark
Immunology in diabetes: an update.
Diabetes/metabolism reviews 1998;14(1):3-29.
1998: Carani B Sanjeevi; William Hagopian; Mona Landin-Olsson; Ingrid Kockum; W Woo; Jerry P Palmer; Ake Lernmark; Gisela Dahlquist
Association between autoantibody markers and subtypes of DR4 and DR4-DQ in Swedish children with insulin-dependent diabetes reveals closer association of tyrosine pyrophosphatase autoimmunity with DR4 than DQ8.
Tissue antigens 1998;51(3):281-6.
1997: Robert D Hoeldtke; Kimberly D Bryner; GG Horvath; M R Byerly; Gerald R Hobbs; S M Marcovina; Ake Lernmark
Antibodies to GAD and glycemic control in recent-onset IDDM.
Diabetes care 1997;20(12):1900-3.
1997: Eva Ortqvist; A Falorni; A Scheynius; Bengt Persson; Ake Lernmark
Age governs gender-dependent islet cell autoreactivity and predicts the clinical course in childhood IDDM.
Acta paediatrica (Oslo, Norway : 1992) 1997;86(11):1166-71.
1997: K Lotfi; GC Sund; R Lowe; Jinko Graham; Mona Landin-Olsson; Ingrid Kockum; Samir S Deeb; Ake Lernmark
The beta cell glucokinase promoter variant is an unlikely risk factor for diabetes mellitus. Diabetes Incidence Study in Sweden (DISS).
Diabetologia 1997;40(8):959-62.
1997: Sabine Bieg; C Möller; T Olsson; Ake Lernmark
The lymphopenia (lyp) gene controls the intrathymic cytokine ratio in congenic BioBreeding rats.
Diabetologia 1997;40(7):786-92.
1997: Sten-A Ivarsson; M Ackefors; Annelie Carlsson; G Ekberg; A Falorni; Ingrid Kockum; Mona Landin-Olsson; Ake Lernmark; Bengt Lindberg; Göran Sundkvist; L Svanberg
Glutamate decarboxylase antibodies in non-diabetic pregnancy precedes insulin-dependent diabetes in the mother but not necessarily in the offspring.
Autoimmunity 1997;26(4):261-9.
1997: Ake Lernmark
Immune surveillance: paraneoplastic or environmental triggers of autoimmunity.
Critical reviews in immunology 1997;17(5-6):437-47.
1996: Carani B Sanjeevi; Peter Hjelmstrom; G Hallmans; Fredrik Wiklund; P Lenner; Tord Angström; Joakim Dillner; Ake Lernmark
Different HLA-DR-DQ haplotypes are associated with cervical intraepithelial neoplasia among human papillomavirus type-16 seropositive and seronegative Swedish women.
International journal of cancer. Journal international du cancer 1996;68(4):409-14.
1996: Ake Lernmark
Glutamic acid decarboxylase--gene to antigen to disease.
Journal of internal medicine 1996;240(5):259-77.
1996: D Agardh; L K Gaur; Elisabet Agardh; Mona Landin-Olsson; Carl-David Agardh; Ake Lernmark
HLA-DQB1*0201/0302 is associated with severe retinopathy in patients with IDDM.
Diabetologia 1996;39(11):1313-7.
1996: Alberto Falorni; M Ackefors; C Carlberg; T Daniels; Bengt Persson; J Robertson; Ake Lernmark
Diagnostic sensitivity of immunodominant epitopes of glutamic acid decarboxylase (GAD65) autoantibodies in childhood IDDM.
Diabetologia 1996;39(9):1091-8.
1996: Akira Kasuga; Alberto Falorni; T Maruyama; Y Ozawa; C E Grubin; K Matsubara; Izumi Takei; Takao Saruta; A Scheynius; Ake Lernmark
HLA class II is associated with the frequency of glutamic acid decarboxylase M(r) 65,000 autoantibodies in Japanese patients with insulin-dependent diabetes mellitus.
Acta diabetologica 1996;33(2):108-13.
1996: J Graham; Ingrid Kockum; Norman E Breslow; Ake Lernmark; E Holmberg
A comparison of three statistical models for IDDM associations with HLA.
Tissue antigens 1996;48(1):1-14.
1996: Jan Ostman; Ake Lernmark; Mona Landin-Olsson; Göran Sundkvist; J Palmer; H Arnqvist; Göran Blohmé; F Lithner; B Littorin; L Nyström; Bengt Scherstén; lars b wibell
Autoimmune (type 1) diabetes in young adults in Sweden.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1996;28(7):348-50.
1996: Ingrid Kockum; Ake Lernmark; G Dahlquist; Alberto Falorni; William Hagopian; Mona Landin-Olsson; L C Li; Holger Luthman; Jerry P Palmer; Carani B Sanjeevi; Göran Sundkvist; I J Ostman
Genetic and immunological findings in patients with newly diagnosed insulin-dependent diabetes mellitus. The Swedish Childhood Diabetes Study Group and The Diabetes Incidence in Sweden Study (DISS) Group.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1996;28(7):344-7.
1996: Tiinamaija Tuomi; P Björses; Alberto Falorni; J Partanen; J Perheentupa; Ake Lernmark; A Miettinen
Antibodies to glutamic acid decarboxylase and insulin-dependent diabetes in patients with autoimmune polyendocrine syndrome type I.
The Journal of clinical endocrinology and metabolism 1996;81(4):1488-94.
1996: Carani B Sanjeevi; Alberto Falorni; Ingrid Kockum; William Hagopian; Ake Lernmark
HLA and glutamic acid decarboxylase in human insulin-dependent diabetes mellitus.
Diabetic medicine : a journal of the British Diabetic Association 1996;13(3):209-17.
1995: Ingrid Kockum; Carani B Sanjeevi; S Eastman; Mona Landin-Olsson; G Dahlquist; Ake Lernmark
Population analysis of protection by HLA-DR and DQ genes from insulin-dependent diabetes mellitus in Swedish children with insulin-dependent diabetes and controls.
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics 1995;22(6):443-65.
1995: Alberto Falorni; Eva Ortqvist; Bengt Persson; Ake Lernmark
Radioimmunoassays for glutamic acid decarboxylase (GAD65) and GAD65 autoantibodies using 35S or 3H recombinant human ligands.
Journal of immunological methods 1995;186(1):89-99.
1995: Alberto Falorni; A Nikoshkov; Stefano Laureti; E Grenbäck; A L Hulting; Giovanni Casucci; Fausto Santeusanio; Paolo Brunetti; Holger Luthman; Ake Lernmark
High diagnostic accuracy for idiopathic Addison's disease with a sensitive radiobinding assay for autoantibodies against recombinant human 21-hydroxylase.
The Journal of clinical endocrinology and metabolism 1995;80(9):2752-5.
1995: A Pettersson; E S Winer; S Weksler-Zangen; Ake Lernmark; Howard J Jacob
Predictability of heterozygosity scores and polymorphism information content values for rat genetic markers.
Mammalian genome : official journal of the International Mammalian Genome Society 1995;6(8):512-20.
1995: William Hagopian; Carani B Sanjeevi; Ingrid Kockum; Mona Landin-Olsson; Allan E Karlsen; Göran Sundkvist; G Dahlquist; J Palmer; Ake Lernmark
Glutamate decarboxylase-, insulin-, and islet cell-antibodies and HLA typing to detect diabetes in a general population-based study of Swedish children.
The Journal of clinical investigation 1995;95(4):1505-11.
1995: Ake Lernmark
Glutamic acid decarboxylase antibodies and diabetes complications. Assay reliability and validity.
Diabetes care 1995;18(2):269-71.
1995: Anders Gottsäter; Mona Landin-Olsson; Ake Lernmark; Per Fernlund; Göran Sundkvist; William Hagopian
Glutamate decarboxylase antibody levels predict rate of beta-cell decline in adult-onset diabetes.
Diabetes research and clinical practice 1995;27(2):133-40.
1995: L Li; Jianjie Jiang; William Hagopian; Allan E Karlsen; M Skelly; Denis Baskin; Ake Lernmark
Differential detection of rat islet and brain glutamic acid decarboxylase (GAD) isoforms with sequence-specific peptide antibodies.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1995;43(1):53-9.
1995: Alberto Falorni; Ingrid Kockum; Carani B Sanjeevi; Ake Lernmark
Pathogenesis of insulin-dependent diabetes mellitus.
Baillière's clinical endocrinology and metabolism 1995;9(1):25-46.
1995: Ake Lernmark; G Klöppel; D Stenger; C Vathanaprida; K Fält; Mona Landin-Olsson; Denis Baskin; Jerry P Palmer; A M Gown; JS Petersen
Heterogeneity of islet pathology in two infants with recent onset diabetes mellitus.
Virchows Archiv : an international journal of pathology 1995;425(6):631-40.
1994: Anders Gottsäter; Mona Landin-Olsson; Ake Lernmark; Per Fernlund; Göran Sundkvist
Islet cell antibodies are associated with beta-cell failure also in obese adult onset diabetic patients.
Acta diabetologica 1994;31(4):226-31.
1994: Ingrid Kockum; Ralf Wassmuth; E Holmberg; Birgitte K Michelsen; Ake Lernmark
Inheritance of MHC class II genes in IDDM studied in population-based affected and control families.
Diabetologia 1994;37(11):1105-12.
1994: W Hao; L Li; V Mehta; Ake Lernmark; Jerry P Palmer
Functional state of the beta cell affects expression of both forms of glutamic acid decarboxylase.
Pancreas 1994;9(5):558-62.
1994: Göran Sundkvist; William Hagopian; Mona Landin-Olsson; Ake Lernmark; L Ohlsson; C Ericsson; J Ahlmén
Islet cell antibodies, but not glutamic acid decarboxylase antibodies, are decreased by plasmapheresis in patients with newly diagnosed insulin-dependent diabetes mellitus.
The Journal of clinical endocrinology and metabolism 1994;78(5):1159-65.
1994: C E Grubin; Terri Daniels; Bert Toivola; Mona Landin-Olsson; William Hagopian; L Li; Allan E Karlsen; E Boel; Birgitte K Michelsen; Ake Lernmark
A novel radioligand binding assay to determine diagnostic accuracy of isoform-specific glutamic acid decarboxylase antibodies in childhood IDDM.
Diabetologia 1994;37(4):344-50.
1994: L Li; William Hagopian; H R Brashear; Terri Daniels; Ake Lernmark
Identification of autoantibody epitopes of glutamic acid decarboxylase in stiff-man syndrome patients.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(2):930-4.
1993: Ralf Wassmuth; S Eastman; Ingrid Kockum; E Holmberg; M Starck; T Lindhagen; Joachim R Kalden; Ake Lernmark; Göran Sundkvist; Stefan Lindgren
HLA DR and DQ RFLP analysis in Crohn's disease.
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics 1993;20(5):429-33.
1993: S Edelhoff; C E Grubin; Allan E Karlsen; D A Alder; D Foster; Christine M Disteche; Ake Lernmark
Mapping of glutamic acid decarboxylase (GAD) genes.
Genomics 1993;17(1):93-7.
1993: Ingrid Kockum; Ralf Wassmuth; E Holmberg; Birgitte K Michelsen; Ake Lernmark
HLA-DQ primarily confers protection and HLA-DR susceptibility in type I (insulin-dependent) diabetes studied in population-based affected families and controls.
American journal of human genetics 1993;53(1):150-67.
1993: Helle Markholst; S Eastman; D Wilson; L Fisher; Ake Lernmark
Decreased weight gain in BB rats before the clinical onset of insulin-dependent diabetes.
Diabetes research and clinical practice 1993;21(1):31-8.
1993: William Hagopian; Allan E Karlsen; JS Petersen; J Teague; A Gervassi; Jianjie Jiang; W Fujimoto; Ake Lernmark
Regulation of glutamic acid decarboxylase diabetes autoantigen expression in highly purified isolated islets from Macaca nemestrina.
Endocrinology 1993;132(6):2674-81.
1993: Anders Gottsäter; Mona Landin-Olsson; Per Fernlund; Ake Lernmark; Göran Sundkvist
Beta-cell function in relation to islet cell antibodies during the first 3 yr after clinical diagnosis of diabetes in type II diabetic patients.
Diabetes care 1993;16(6):902-10.
1993: J L Neifing; Carla J Greenbaum; Steven E Kahn; D K McCulloch; H Barmeier; Ake Lernmark; Jerry P Palmer
Prospective evaluation of beta-cell function in insulin autoantibody-positive relatives of insulin-dependent diabetic patients.
Metabolism: clinical and experimental 1993;42(4):482-6.
1993: William Hagopian; Birgitte K Michelsen; Allan E Karlsen; F Larsen; A Moody; C E Grubin; R Rowe; J Petersen; R McEvoy; Ake Lernmark
Autoantibodies in IDDM primarily recognize the 65,000-M(r) rather than the 67,000-M(r) isoform of glutamic acid decarboxylase.
Diabetes 1993;42(4):631-6.
1993: Sten-A Ivarsson; S Eriksson; Ingrid Kockum; Ake Lernmark; Stefan Lindgren; K O Nilsson; Göran Sundkvist; Ralf Wassmuth
HLA-DR3, DQ2 homozygosity in two patients with insulin-dependent diabetes mellitus superimposed with ulcerative colitis and primary sclerosing cholangitis.
Journal of internal medicine 1993;233(3):281-6.
1993: William Hagopian; Allan E Karlsen; Anders Gottsäter; Mona Landin-Olsson; C E Grubin; Göran Sundkvist; JS Petersen; E Boel; Thomas Dyrberg; Ake Lernmark
Quantitative assay using recombinant human islet glutamic acid decarboxylase (GAD65) shows that 64K autoantibody positivity at onset predicts diabetes type.
The Journal of clinical investigation 1993;91(1):368-74.
1993: L W Jobe; R Ubungen; C J Goodner; Denis Baskin; P Braquet; Ake Lernmark
Protection from BB rat diabetes by the platelet-activating factor inhibitor BN50730.
Autoimmunity 1993;16(4):259-66.
1992: Ake Lernmark; P J Morris; Arthur H Rubenstein
Diabetes and frontiers of research. Introduction.
Diabetologia 1992;35 Suppl 2():A9-11.
1992: Carla J Greenbaum; Jerry P Palmer; S Nagataki; Y Yamaguchi; J L Molenaar; W A Van Beers; N K MacLaren; Ake Lernmark
Improved specificity of ICA assays in the Fourth International Immunology of Diabetes Serum Exchange Workshop.
Diabetes 1992;41(12):1570-4.
1992: Ake Lernmark
Immune intervention yes, but for what reason, for whom, when and how?
Diabetologia 1992;35(11):1096-8.
1992: Mona Landin-Olsson; J P Palmer; Ake Lernmark; L Blom; Göran Sundkvist; L Nyström; G Dahlquist
Predictive value of islet cell and insulin autoantibodies for type 1 (insulin-dependent) diabetes mellitus in a population-based study of newly-diagnosed diabetic and matched control children.
Diabetologia 1992;35(11):1068-73.
1992: Anders Gottsäter; Mona Landin-Olsson; Per Fernlund; B Gullberg; Ake Lernmark; Göran Sundkvist
Pancreatic beta-cell function evaluated by intravenous glucose and glucagon stimulation. A comparison between insulin and C-peptide to measure insulin secretion.
Scandinavian journal of clinical and laboratory investigation 1992;52(7):631-9.
1992: Allan E Karlsen; William Hagopian; JS Petersen; E Boel; Thomas Dyrberg; C E Grubin; Birgitte K Michelsen; Ole D Madsen; Ake Lernmark
Recombinant glutamic acid decarboxylase (representing the single isoform expressed in human islets) detects IDDM-associated 64,000-M(r) autoantibodies.
Diabetes 1992;41(10):1355-9.
1992: Mona Landin-Olsson; F Anders Karlsson; Ake Lernmark; G Sundkvist
Islet cell and thyrogastric antibodies in 633 consecutive 15- to 34-yr-old patients in the diabetes incidence study in Sweden.
Diabetes 1992;41(8):1022-7.
1992: L W Jobe; S Vertrees; C A Wilson; C Jacobs; D L Wilson; K S Picha; P Baker; Ake Lernmark
In vivo effects of interleukin-1 beta on blood leukocytes in BB rats prone or resistant to diabetes.
Autoimmunity 1992;11(4):233-7.
1992: H Bärmeier; J Ahlmén; Mona Landin-Olsson; R V Rajotte; Göran Sundkvist; G Warnock; Ake Lernmark
Quantitative analysis of islet glutamic acid decarboxylase p64 autoantibodies in insulin-dependent diabetes mellitus.
Autoimmunity 1992;13(3):187-96.
1991: B Marner; G Bille; M Christy; E M Damsgaard; S Garne; E Heinze; S Larsen; Ake Lernmark; T Mandrup-Poulsen; J Nerup
Islet cell cytoplasmic antibodies (ICA) in diabetes and disorders of glucose tolerance.
Diabetic medicine : a journal of the British Diabetic Association 1991;8(9):812-6.
1991: H Bärmeier; D K McCulloch; J L Neifing; G Warnock; R V Rajotte; Jerry P Palmer; Ake Lernmark
Risk for developing type 1 (insulin-dependent) diabetes mellitus and the presence of islet 64K antibodies.
Diabetologia 1991;34(10):727-33.
1991: S Vertrees; C A Wilson; R Ubungen; D Wilson; Denis Baskin; Bert Toivola; C Jacobs; Norman boiani; P Baker; Ake Lernmark
Interleukin-1 beta regulation of islet and thyroid autoimmunity in the BB rat.
Journal of autoimmunity 1991;4(5):717-32.
1991: Göran Sundkvist; A Bergqvist; H Weibull; D Bergqvist; K Fält; M L Olsson; Ake Lernmark
Islet cell antibody reactivity with human fetal pancreatic islets.
Diabetes research and clinical practice 1991;14(1):1-7.
1991: Ake Lernmark; H Bärmeier; S Dube; William Hagopian; Allan E Karlsen; Ralf Wassmuth
Autoimmunity of diabetes.
Endocrinology and metabolism clinics of North America 1991;20(3):589-617.
1991: Helle Markholst; S Eastman; D Wilson; B E Andreasen; Ake Lernmark
Diabetes segregates as a single locus in crosses between inbred BB rats prone or resistant to diabetes.
The Journal of experimental medicine 1991;174(1):297-300.
1991: Ake Lernmark; J L Molenaar; W A van Beers; Y Yamaguchi; S Nagataki; J Ludvigsson; N K Maclaren
The Fourth International Serum Exchange Workshop to standardize cytoplasmic islet cell antibodies. The Immunology and Diabetes Workshops and Participating Laboratories.
Diabetologia 1991;34(7):534-5.
1991: S Eastman; Helle Markholst; D Wilson; Ake Lernmark
Leukocytosis at the onset of diabetes in crosses of inbred BB rats.
Diabetes research and clinical practice 1991;12(2):113-23.
1991: Allan E Karlsen; W Y Fujimoto; P Rabinovitch; S Dube; Ake Lernmark
Effects of sodium butyrate on proliferation-dependent insulin gene expression and insulin release in glucose-sensitive RIN-5AH cells.
The Journal of biological chemistry 1991;266(12):7542-8.
1991: J C Beck; C J Goodner; C Wilson; D Wilson; D Glidden; Denis Baskin; Ake Lernmark; P Braquet
Effects of ginkgolide B, a platelet-activating factor inhibitor on insulitis in the spontaneously diabetic BB rat.
Autoimmunity 1991;9(3):225-35.
1990: Ake Lernmark; H Bärmeier; S Dube; William Hagopian; Allan E Karlsen; Helle Markholst; C Wilson; Ralf Wassmuth
Molecular analysis of the pathogenesis of beta-cell destruction in insulin-dependent diabetes mellitus.
The Western journal of medicine 1990;153(5):499-502.
1990: B Kuglin; H Kolb; Carla J Greenbaum; N K Maclaren; Ake Lernmark; Jerry P Palmer
The Fourth International Workshop on the Standardisation of Insulin Autoantibody Workshop.
Diabetologia 1990;33(10):638-9.
1990: Helle Markholst; L J Klaff; G Klöppel; Ake Lernmark; J P Mordes; J Palmer
Lack of systematically found insulin autoantibodies in spontaneously diabetic BB rats.
Diabetes 1990;39(6):720-7.
1990: C A Wilson; C Jacobs; P Baker; Denis Baskin; Steven K Dower; Ake Lernmark; Bert Toivola; S Vertrees; D Wilson
IL-1 beta modulation of spontaneous autoimmune diabetes and thyroiditis in the BB rat.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(10):3784-8.
1990: Mona Landin-Olsson; Anders Borgström; L Blom; Göran Sundkvist; Ake Lernmark
Immunoreactive trypsin(ogen) in the sera of children with recent-onset insulin-dependent diabetes and matched controls. The Swedish Childhood Diabetes Group.
Pancreas 1990;5(3):241-7.
1990: Allan E Karlsen; Ake Lernmark; Hans Kofod; Thomas Dyrberg
A novel affinity purification method to isolate peptide specific antibodies.
Journal of immunological methods 1990;128(2):151-7.
1990: Birgitte K Michelsen; Ralf Wassmuth; J Ludvigsson; Ake Lernmark; Gerald Nepom; L Fisher
HLA heterozygosity in insulin-dependent diabetes is most frequent at the DQ locus.
Scandinavian journal of immunology 1990;31(4):405-13.
1990: M R Christie; Daniel G Pipeleers; Ake Lernmark; Steinunn Baekkeskov
Cellular and subcellular localization of an Mr 64,000 protein autoantigen in insulin-dependent diabetes.
The Journal of biological chemistry 1990;265(1):376-81.
1990: Birgitte K Michelsen; Thomas Dyrberg; Henrik Vissing; Palle Serup; Ake Lernmark
HLA-DQ and -DX genes in insulin-dependent diabetes mellitus.
Current topics in microbiology and immunology 1990;164():57-68.
1989: Ralf Wassmuth; Ake Lernmark
The genetics of susceptibility to diabetes.
Clinical immunology and immunopathology 1989;53(3):358-99.
1989: Annette Møldrup; Nils Billestrup; N A Thorn; Ake Lernmark; Jens H Nielsen
Multiple growth hormone-binding proteins are expressed on insulin-producing cells.
Molecular endocrinology (Baltimore, Md.) 1989;3(8):1173-82.
1989: D Atar; Thomas Dyrberg; Birgitte K Michelsen; Allan E Karlsen; Hans Kofod; J Mølvig; Ake Lernmark
Site-specific antibodies distinguish single amino acid substitutions in position 57 in HLA-DQ beta-chain alleles associated with insulin-dependent diabetes.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(2):533-8.
1989: Mona Landin-Olsson; A Karlsson; G Dahlquist; L Blom; Ake Lernmark; Göran Sundkvist
Islet cell and other organ-specific autoantibodies in all children developing type 1 (insulin-dependent) diabetes mellitus in Sweden during one year and in matched control children.
Diabetologia 1989;32(6):387-95.
1989: G Contreas; Thomas Dyrberg; Ole D Madsen; Helle Markholst; Ake Lernmark
Increased levels of circulating immune complexes are not associated with diabetes in BB rats.
Diabetes research (Edinburgh, Scotland) 1989;10(3):109-13.
1989: W A Hansen; M R Christie; R Kahn; A Norgaard; I Abel; A M Petersen; D W Jorgensen; S Baekkeskov; J H Nielsen; Ake Lernmark
Supravital dithizone staining in the isolation of human and rat pancreatic islets.
Diabetes research (Edinburgh, Scotland) 1989;10(2):53-7.
1989: M Löhr; Helle Markholst; Thomas Dyrberg; G Klöppel; M Oberholzer; Ake Lernmark
Insulitis and diabetes are preceded by a decrease in beta cell volume in diabetes-prone BB rats.
Pancreas 1989;4(1):95-100.
1989: KC Herold; W Kastern; Helle Markholst; Ake Lernmark
Derivation of non-lymphopenic BB rats with an intercross breeding.
Autoimmunity 1989;3(2):83-93.
1988: I Matsuba; Ake Lernmark; O Madsen; Birgitte K Michelsen; Jens H Nielsen; J Scholler; Henrik Vissing; B Welinder; Niels Tommerup; M Mikkelsen
Gene probes to detect cross-culture contamination in hormone producing cell lines.
In vitro cellular & developmental biology : journal of the Tissue Culture Association 1988;24(11):1071-6.
1988: Ole D Madsen; L C Andersen; Birgitte K Michelsen; D Owerbach; L I Larsson; Ake Lernmark; D F Steiner
Tissue-specific expression of transfected human insulin genes in pluripotent clonal rat insulinoma lines induced during passage in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(18):6652-6.
1988: M Christie; M Landin-Olsson; G Sundkvist; G Dahlquist; Ake Lernmark; Steinunn Baekkeskov
Antibodies to a Mr-64,000 islet cell protein in Swedish children with newly diagnosed type 1 (insulin-dependent) diabetes.
Diabetologia 1988;31(8):597-602.
1988: M Ziegler; S Teneberg; Sabine Witt; B Ziegler; B Hehmke; K D Kohnert; J Egeberg; K A Karlsson; Ake Lernmark
Islet beta-cytotoxic monoclonal antibody against glycolipids in experimental diabetes induced by low dose streptozotocin and Freund's adjuvant.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(12):4144-50.
1988: S A Ivarsson; B Marner; Ake Lernmark; K O Nilsson
Nonislet pancreatic autoantibodies in sibship with permanent neonatal insulin-dependent diabetes mellitus.
Diabetes 1988;37(3):347-50.
1988: Helle Markholst; Ake Lernmark
Reduced pancreatic insulin is associated with retarded growth of the pancreas in young prediabetic BB rats.
Pancreas 1988;3(2):140-4.
1988: Ake Lernmark; Helle Markholst; H Laursen; G Contreas; M Altieri; Steinunn Baekkeskov; R Herold; W Kastern; Ole D Madsen
[Spontaneous diabetes and diabetes induced by streptozotocin in the rat and mouse].
Journées annuelles de diabétologie de l'Hôtel-Dieu 1988;():15-31.
1987: Ake Lernmark; S Li; Steinunn Baekkeskov; M Christie; Birgitte K Michelsen; J Ursing; M L Olsson; G Sundkvist
Islet-specific immune mechanisms.
Diabetes/metabolism reviews 1987;3(4):959-80.
1986: G Contreas; Ole D Madsen; Henrik Vissing; Ake Lernmark
A simple assay for the detection of antibodies to endocrine islet cell surface antigens.
Journal of immunological methods 1986;95(1):135-9.
1986: A Svenningsen; Thomas Dyrberg; Helle Markholst; C Binder; Ake Lernmark
Insulin release and pancreatic insulin is reduced in young prediabetic BB rats.
Acta endocrinologica 1986;112(3):367-71.
1985: B Marner; T Agner; C Binder; Ake Lernmark; J Nerup; T Mandrup-Poulsen; S Walldorff
Increased reduction in fasting C-peptide is associated with islet cell antibodies in type 1 (insulin-dependent) diabetic patients.
Diabetologia 1985;28(12):875-80.
1985: Birgitte K Michelsen; Steinunn Baekkeskov; T Deufel; W Kastern; Hans Kofod; Ake Lernmark; Henrik Vissing
[Mechanism and genetic control of the autoimmune response directed against beta-pancreatic cells in insulin-dependent diabetes].
Journées annuelles de diabétologie de l'Hôtel-Dieu 1985;():171-82.