Derek LeRoith

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Publications

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Novosyadlyy R; Vijayakumar A; Lann D; Fierz Y; Kurshan N; LeRoith D
Physical and functional interaction between polyoma virus middle T antigen and insulin and IGF-I receptors is required for oncogene activation and tumour initiation.
Leroith Derek
Pediatric endocrinology: part I. Foreword.
Wu Yingjie; Sun Hui; Yakar Shoshana; LeRoith Derek
Elevated levels of insulin-like growth factor (IGF)-I in serum rescue the severe growth retardation of IGF-I null mice.

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All Publications

2009: Novosyadlyy R; Vijayakumar A; Lann D; Fierz Y; Kurshan N; LeRoith D
Physical and functional interaction between polyoma virus middle T antigen and insulin and IGF-I receptors is required for oncogene activation and tumour initiation.
Oncogene 2009;28(39):3477-86.
2009: Leroith Derek
Pediatric endocrinology: part I. Foreword.
Endocrinology and metabolism clinics of North America 2009;38(3):xi-xiii.
2009: Wu Yingjie; Sun Hui; Yakar Shoshana; LeRoith Derek
Elevated levels of insulin-like growth factor (IGF)-I in serum rescue the severe growth retardation of IGF-I null mice.
Endocrinology 2009;150(9):4395-403.
2009: Kawashima Y; Chen J; Sun H; Lann D; Hajjar R J; Yakar S; Leroith D
Apolipoprotein E deficiency abrogates insulin resistance in a mouse model of type 2 diabetes mellitus.
Diabetologia 2009;52(7):1434-41.
2009: LeRoith Derek
This issue of Endocrinology and Metabolism Clinics focuses on clinical and molecular advances in autoimmune endocrine conditions. Foreword.
Endocrinology and metabolism clinics of North America 2009;38(2):xiii-xv.
2009: Hong Sung-Hyeok; Briggs Joseph; Newman Rachel; Hoffman Karen; Mendoza Arnulfo; LeRoith Derek; Helman Lee; Yakar Shoshana; Khanna Chand
Murine osteosarcoma primary tumour growth and metastatic progression is maintained after marked suppression of serum insulin-like growth factor I.
International journal of cancer. Journal international du cancer 2009;124(9):2042-9.
2009: Kawashima Yuki; Fritton J Christopher; Yakar Shoshana; Epstein Sol; Schaffler Mitchell B; Jepsen Karl J; LeRoith Derek
Type 2 diabetic mice demonstrate slender long bones with increased fragility secondary to increased osteoclastogenesis.
Bone 2009;44(4):648-55.
2009: LeRoith Derek
Basic aspects and clinical applicability in the field of lipidology. Foreword.
Endocrinology and metabolism clinics of North America 2009;38(1):xiii-xv.
2009: Yakar Shoshana; Rosen Clifford J; Bouxsein Mary L; Sun Hui; Mejia Wilson; Kawashima Yuki; Wu Yingjie; Emerton Kelly; Williams Valerie; Jepsen Karl; Schaffler Mitchell B; Majeska Robert J; Gavrilova Oksana; Gutierrez Mariana; Hwang David; Pennisi Patricia; Frystyk Jan; Boisclair Yves; Pintar John; Jasper Héctor; Domene Horacio; Cohen Pinchas; Clemmons David; LeRoith Derek
Serum complexes of insulin-like growth factor-1 modulate skeletal integrity and carbohydrate metabolism.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(3):709-19.
2009: Lim Gareth E; Huang Guan J; Flora Nina; LeRoith Derek; Rhodes Christopher J; Brubaker Patricia L
Insulin regulates glucagon-like peptide-1 secretion from the enteroendocrine L cell.
Endocrinology 2009;150(2):580-91.
2009: LeRoith Derek
Gender differences in metabolic disorders.
Gender medicine : official journal of the Partnership for Gender-Specific Medicine at Columbia University 2009;6 Suppl 1():1-3.
2008: Radbill Brian; Murphy Barbara; LeRoith Derek
Rationale and strategies for early detection and management of diabetic kidney disease.
Mayo Clinic proceedings. Mayo Clinic 2008;83(12):1373-81.
2008: Lann Danielle; LeRoith Derek
The role of endocrine insulin-like growth factor-I and insulin in breast cancer.
Journal of mammary gland biology and neoplasia 2008;13(4):371-9.
2008: Leroith Derek
Foreword. Control of feeding behavior and the peripheral metabolism by the hypothalamus.
Endocrinology and metabolism clinics of North America 2008;37(4):xi-xii.
2008: LeRoith Derek
Insulin-like growth factors and the brain.
Endocrinology 2008;149(12):5951.
2008: Toyoshima Yuka; Monson Christopher; Duan Cunming; Wu Yingjie; Gao Chuan; Yakar Shoshana; Sadler Kirsten C; LeRoith Derek
The role of insulin receptor signaling in zebrafish embryogenesis.
Endocrinology 2008;149(12):5996-6005.
2008: Kim Jaetaek; Wende Adam R; Sena Sandra; Theobald Heather A; Soto Jamie; Sloan Crystal; Wayment Benjamin E; Litwin Sheldon E; Holzenberger Martin; LeRoith Derek; Abel E Dale
Insulin-like growth factor I receptor signaling is required for exercise-induced cardiac hypertrophy.
Molecular endocrinology (Baltimore, Md.) 2008;22(11):2531-43.
2008: LeRoith D; Novosyadlyy R; Gallagher E J; Lann D; Vijayakumar A; Yakar S
Obesity and type 2 diabetes are associated with an increased risk of developing cancer and a worse prognosis; epidemiological and mechanistic evidence.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2008;116 Suppl 1():S4-6.
2008: Gallagher Emily Jane; LeRoith Derek; Karnieli Eddy
The metabolic syndrome--from insulin resistance to obesity and diabetes.
Endocrinology and metabolism clinics of North America 2008;37(3):559-79, vii.
2008: LeRoith Derek
Endocrinology and metabolism clinics of North America. Foreword.
Endocrinology and metabolism clinics of North America 2008;37(3):xiii-xvi.
2008: Novosyadlyy R; Kurshan N; Lann D; Vijayakumar A; Yakar S; LeRoith D
Insulin-like growth factor-I protects cells from ER stress-induced apoptosis via enhancement of the adaptive capacity of endoplasmic reticulum.
Cell death and differentiation 2008;15(8):1304-17.
2008: Epstein Sol; Leroith Derek
Diabetes and fragility fractures - a burgeoning epidemic?
Bone 2008;43(1):3-6.
2008: LeRoith Derek
The articles cover all of the aspects from a basic and practical point of view. Foreword.
Endocrinology and metabolism clinics of North America 2008;37(2):xiii-xv.
2008: Lann D; Gallagher E; Leroith D
Insulin resistance and the metabolic syndrome.
Minerva medica 2008;99(3):253-62.
2008: Zhang Jinhui; Wu Yingjie; Zhang Yuanyuan; Leroith Derek; Bernlohr David A; Chen Xiaoli
The role of lipocalin 2 in the regulation of inflammation in adipocytes and macrophages.
Molecular endocrinology (Baltimore, Md.) 2008;22(6):1416-26.
2008: Moore Tricia; Carbajal Steve; Beltran Linda; Perkins Susan N; Yakar Shoshana; Leroith Derek; Hursting Stephen D; Digiovanni John
Reduced susceptibility to two-stage skin carcinogenesis in mice with low circulating insulin-like growth factor I levels.
Cancer research 2008;68(10):3680-8.
2008: Anzo Makoto; Cobb Laura J; Hwang David L; Mehta Hemal; Said Jonathan W; Yakar Shoshana; LeRoith Derek; Cohen Pinchas
Targeted deletion of hepatic Igf1 in TRAMP mice leads to dramatic alterations in the circulating insulin-like growth factor axis but does not reduce tumor progression.
Cancer research 2008;68(9):3342-9.
2008: Bentov Itay; Narla Goutham; Schayek Hagit; Akita Kuhihara; Plymate Stephen R; LeRoith Derek; Friedman Scott L; Werner Haim
Insulin-like growth factor-i regulates Kruppel-like factor-6 gene expression in a p53-dependent manner.
Endocrinology 2008;149(4):1890-7.
2008: Leroith Derek; Accili Domenico
Mechanisms of disease: using genetically altered mice to study concepts of type 2 diabetes.
Nature clinical practice. Endocrinology & metabolism 2008;4(3):164-72.
2008: LeRoith Derek
Clinical relevance of systemic and local IGF-I: lessons from animal models.
Pediatric endocrinology reviews : PER 2008;5 Suppl 2():739-43.
2007: Leroith Derek
Our evolving understanding of getting to goal using insulin in type 2 diabetes.
Endocrinology and metabolism clinics of North America 2007;36 Suppl 2():9-19.
2007: Lann Danielle; LeRoith Derek
Insulin resistance as the underlying cause for the metabolic syndrome.
The Medical clinics of North America 2007;91(6):1063-77, viii.
2007: Inagaki Kenjiro; Tiulpakov Anatoly; Rubtsov Petr; Sverdlova Polina; Peterkova Valentina; Yakar Shoshana; Terekhov Sergei; LeRoith Derek
A familial insulin-like growth factor-I receptor mutant leads to short stature: clinical and biochemical characterization.
The Journal of clinical endocrinology and metabolism 2007;92(4):1542-8.
2007: LeRoith Derek; Yakar Shoshana
Mechanisms of disease: metabolic effects of growth hormone and insulin-like growth factor 1.
Nature clinical practice. Endocrinology & metabolism 2007;3(3):302-10.
2007: Samani Amir Abbas; Yakar Shoshana; LeRoith Derek; Brodt Pnina
The role of the IGF system in cancer growth and metastasis: overview and recent insights.
Endocrine reviews 2007;28(1):20-47.
2007: LeRoith Derek
Dyslipidemia and glucose dysregulation in overweight and obese patients.
Clinical cornerstone 2007;8(3):38-52.
2007: LeRoith Derek
Treatment of diabetes: a clinical update on insulin trials.
Clinical cornerstone 2007;8(2):21-9; discussion 30-2.
2007: LeRoith Derek; Rayfield Elliot J
The benefits of tight glycemic control in type 2 diabetes mellitus.
Clinical cornerstone 2007;8 Suppl 7():S19-29.
2006: Yakar Shoshana; Nunez Nomeli P; Pennisi Patricia; Brodt Pnina; Sun Hui; Fallavollita Lucia; Zhao Hong; Scavo Louis; Novosyadlyy Ruslan; Kurshan Naamit; Stannard Bethel; East-Palmer Joyce; Smith Nicole C P; Perkins Susan N; Fuchs-Young Robin; Barrett J Carl; Hursting Stephen D; LeRoith Derek
Increased tumor growth in mice with diet-induced obesity: impact of ovarian hormones.
Endocrinology 2006;147(12):5826-34.
2006: Loladze Aimee V; Stull Malinda A; Rowzee Anne M; Demarco Jean; Lantry James H; Rosen Clifford J; Leroith Derek; Wagner Kay-Uwe; Hennighausen Lothar; Wood Teresa L
Epithelial-specific and stage-specific functions of insulin-like growth factor-I during postnatal mammary development.
Endocrinology 2006;147(11):5412-23.
2006: Bromberg Jonathan S; LeRoith Derek
Diabetes cure--is the glass half full?
The New England journal of medicine 2006;355(13):1372-4.
2006: Kim Chul-Hee; Pennisi Patricia; Zhao Hong; Yakar Shoshana; Kaufman Jeanne B; Iganaki Kenjiro; Shiloach Joseph; Scherer Philipp E; Quon Michael J; LeRoith Derek
MKR mice are resistant to the metabolic actions of both insulin and adiponectin: discordance between insulin resistance and adiponectin responsiveness.
American journal of physiology. Endocrinology and metabolism 2006;291(2):E298-305.
2006: Shukla Vivek; Coumoul Xavier; Cao Liu; Wang Rui-Hong; Xiao Cuiying; Xu Xiaoling; Andò Sebastiano; Yakar Shoshana; Leroith Derek; Deng Chuxia
Absence of the full-length breast cancer-associated gene-1 leads to increased expression of insulin-like growth factor signaling axis members.
Cancer research 2006;66(14):7151-7.
2006: Xu Xiaoling; Kobayashi Shogo; Qiao Wenhui; Li Cuiling; Xiao Cuiying; Radaeva Svetlana; Stiles Bangyan; Wang Rui-Hong; Ohara Nobuya; Yoshino Tadashi; LeRoith Derek; Torbenson Michael S; Gores Gregory J; Wu Hong; Gao Bin; Deng Chu-Xia
Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice.
The Journal of clinical investigation 2006;116(7):1843-52.
2006: Kim Hyunsook; Pennisi Patricia A; Gavrilova Oksana; Pack Stephanie; Jou William; Setser-Portas Jennifer; East-Palmer Joyce; Tang Yan; Manganiello Vincent C; Leroith Derek
Effect of adipocyte beta3-adrenergic receptor activation on the type 2 diabetic MKR mice.
American journal of physiology. Endocrinology and metabolism 2006;290(6):E1227-36.
2006: Pennisi Patricia; Gavrilova Oksana; Setser-Portas Jennifer; Jou William; Santopietro Stefania; Clemmons David; Yakar Shoshana; LeRoith Derek
Recombinant human insulin-like growth factor-I treatment inhibits gluconeogenesis in a transgenic mouse model of type 2 diabetes mellitus.
Endocrinology 2006;147(6):2619-30.
2006: Tamler Ronald; LeRoith Derek; Roth Jesse
Intensive insulin therapy in the medical ICU.
The New England journal of medicine 2006;354(19):2069-71; author reply 2069-71.
2006: Yakar Shoshana; Bouxsein Mary L; Canalis Ernesto; Sun Hui; Glatt Vaida; Gundberg Caren; Cohen Pinchas; Hwang David; Boisclair Yves; Leroith Derek; Rosen Clifford J
The ternary IGF complex influences postnatal bone acquisition and the skeletal response to intermittent parathyroid hormone.
The Journal of endocrinology 2006;189(2):289-99.
2006: Sadagurski Marianna; Yakar Shoshana; Weingarten Galina; Holzenberger Martin; Rhodes Christopher J; Breitkreutz Dirk; Leroith Derek; Wertheimer Efrat
Insulin-like growth factor 1 receptor signaling regulates skin development and inhibits skin keratinocyte differentiation.
Molecular and cellular biology 2006;26(7):2675-87.
2006: Asghar Z; Yau D; Chan F; Leroith D; Chan C B; Wheeler M B
Insulin resistance causes increased beta-cell mass but defective glucose-stimulated insulin secretion in a murine model of type 2 diabetes.
Diabetologia 2006;49(1):90-9.
2006: Leroith Derek
ASpecial Focus on Obesity.
Metabolic syndrome and related disorders 2006;4(1):35-6.
2006: LeRoith Derek; Gavrilova Oksana
Mouse models created to study the pathophysiology of Type 2 diabetes.
The international journal of biochemistry & cell biology 2006;38(5-6):904-12.
2005: Barbour Linda A; Mizanoor Rahman Shaikh; Gurevich Inga; Leitner J Wayne; Fischer Stephanie J; Roper Michael D; Knotts Trina A; Vo Yen; McCurdy Carrie E; Yakar Shoshana; Leroith Derek; Kahn C Ronald; Cantley Lewis C; Friedman Jacob E; Draznin Boris
Increased P85alpha is a potent negative regulator of skeletal muscle insulin signaling and induces in vivo insulin resistance associated with growth hormone excess.
The Journal of biological chemistry 2005;280(45):37489-94.
2005: LeRoith Derek; Smith Deirdre O
Monitoring glycemic control: the cornerstone of diabetes care.
Clinical therapeutics 2005;27(10):1489-99.
2005: Freedman Renee J; Malkovska Vera; LeRoith Derek; Collins Michael T
Hodgkin lymphoma in temporal association with growth hormone replacement.
Endocrine journal 2005;52(5):571-5.
2005: LeRoith Derek
Diabetes in the aging male.
The aging male : the official journal of the International Society for the Study of the Aging Male 2005;8(3-4):133-4.
2005: Yakar Shoshana; Sun Hui; Zhao Hong; Pennisi Patricia; Toyoshima Yuka; Setser Jennifer; Stannard Bethel; Scavo Louis; Leroith Derek
Metabolic effects of IGF-I deficiency: lessons from mouse models.
Pediatric endocrinology reviews : PER 2005;3(1):11-9.
2005: Toyoshima Yuka; Gavrilova Oksana; Yakar Shoshana; Jou William; Pack Stephanie; Asghar Zeenat; Wheeler Michael B; LeRoith Derek
Leptin improves insulin resistance and hyperglycemia in a mouse model of type 2 diabetes.
Endocrinology 2005;146(9):4024-35.
2005: Yakar Shoshana; Leroith Derek; Brodt Pnina
The role of the growth hormone/insulin-like growth factor axis in tumor growth and progression: Lessons from animal models.
Cytokine & growth factor reviews 2005;16(4-5):407-20.
2005: Kim Hyunsook; Barton Elisabeth; Muja Naser; Yakar Shoshana; Pennisi Patricia; Leroith Derek
Intact insulin and insulin-like growth factor-I receptor signaling is required for growth hormone effects on skeletal muscle growth and function in vivo.
Endocrinology 2005;146(4):1772-9.
2005: Yakar Shoshana; Kim Hyunsook; Zhao Hong; Toyoshima Yuka; Pennisi Patricia; Gavrilova Oksana; Leroith Derek
The growth hormone-insulin like growth factor axis revisited: lessons from IGF-1 and IGF-1 receptor gene targeting.
Pediatric nephrology (Berlin, Germany) 2005;20(3):251-4.
2005: LeRoith Derek; Fonseca Vivian; Vinik Aaron
Metabolic memory in diabetes--focus on insulin.
Diabetes/metabolism research and reviews 2005;21(2):85-90.
2005: Leroith Derek; Nissley Peter
Knock your SOCS off!
The Journal of clinical investigation 2005;115(2):233-6.
2005: Fernandez Ana M; LeRoith Derek
Skeletal muscle.
Advances in experimental medicine and biology 2005;567():117-47.
2005: Yakar S; Pennisi P; Kim C H; Zhao H; Toyoshima Y; Gavrilova O; LeRoith D
Studies involving the GH-IGF axis: Lessons from IGF-I and IGF-I receptor gene targeting mouse models.
Journal of endocrinological investigation 2005;28(5 Suppl):19-22.
2005: Yakar Shoshana; Pennisi Patricia; Wu Yiping; Zhao Hong; LeRoith Derek
Clinical relevance of systemic and local IGF-I.
Endocrine development 2005;9():11-6.
2004: Lu Yarong; Herrera Pedro L; Guo Yubin; Sun David; Tang Zhengyi; LeRoith Derek; Liu Jun-Li
Pancreatic-specific inactivation of IGF-I gene causes enlarged pancreatic islets and significant resistance to diabetes.
Diabetes 2004;53(12):3131-41.
2004: Rose Annabel; Froment Pascal; Perrot Valérie; Quon Michael J; LeRoith Derek; Dupont Joëlle
The luteinizing hormone-releasing hormone inhibits the anti-apoptotic activity of insulin-like growth factor-1 in pituitary alphaT3 cells by protein kinase Calpha-mediated negative regulation of Akt.
The Journal of biological chemistry 2004;279(50):52500-16.
2004: Zhao Hong; Yakar Shoshana; Gavrilova Oksana; Sun Hui; Zhang Yang; Kim Hyunsook; Setser Jennifer; Jou William; LeRoith Derek
Phloridzin improves hyperglycemia but not hepatic insulin resistance in a transgenic mouse model of type 2 diabetes.
Diabetes 2004;53(11):2901-9.
2004: Liu Yan-Fang; Herschkovitz Avia; Boura-Halfon Sigalit; Ronen Denise; Paz Keren; Leroith Derek; Zick Yehiel
Serine phosphorylation proximal to its phosphotyrosine binding domain inhibits insulin receptor substrate 1 function and promotes insulin resistance.
Molecular and cellular biology 2004;24(21):9668-81.
2004: Matsusue Kimihiko; Gavrilova Oksana; Lambert Gilles; Brewer H Bryan; Ward Jerrold M; Inoue Yusuke; LeRoith Derek; Gonzalez Frank J
Hepatic CCAAT/enhancer binding protein alpha mediates induction of lipogenesis and regulation of glucose homeostasis in leptin-deficient mice.
Molecular endocrinology (Baltimore, Md.) 2004;18(11):2751-64.
2004: Pennisi Patricia A; Kopchick John J; Thorgeirsson Snorri; LeRoith Derek; Yakar Shoshana
Role of growth hormone (GH) in liver regeneration.
Endocrinology 2004;145(10):4748-55.
2004: Héron-Milhavet Lisa; Haluzik Martin; Yakar Shoshana; Gavrilova Oksana; Pack Stephanie; Jou William C; Ibrahimi Azeddine; Kim Hyunsook; Hunt Desmond; Yau Daphne; Asghar Zeenat; Joseph Jamie; Wheeler Michael B; Abumrad Nada A; LeRoith Derek
Muscle-specific overexpression of CD36 reverses the insulin resistance and diabetes of MKR mice.
Endocrinology 2004;145(10):4667-76.
2004: Zhang Yang; Karas Michael; Zhao Hong; Yakar Shoshana; LeRoith Derek
14-3-3sigma mediation of cell cycle progression is p53-independent in response to insulin-like growth factor-I receptor activation.
The Journal of biological chemistry 2004;279(33):34353-60.
2004: Scavo Louis M; Karas Michael; Murray Malissa; Leroith Derek
Insulin-like growth factor-I stimulates both cell growth and lipogenesis during differentiation of human mesenchymal stem cells into adipocytes.
The Journal of clinical endocrinology and metabolism 2004;89(7):3543-53.
2004: LeRoith Derek
Editorial: A blast from the past--insulin does it again!
The Journal of clinical endocrinology and metabolism 2004;89(7):3103-4.
2004: Toyoshima Yuka; Karas Michael; Yakar Shoshana; Dupont Joelle; Lee Helman; LeRoith Derek
TDAG51 mediates the effects of insulin-like growth factor I (IGF-I) on cell survival.
The Journal of biological chemistry 2004;279(24):25898-904.
2004: Héron-Milhavet Lisa; Xue-Jun Yang; Vannucci Susan J; Wood Teresa L; Willing Lisa B; Stannard Bethel; Hernandez-Sanchez Catalina; Mobbs Charles; Virsolvy Anne; LeRoith Derek
Protection against hypoxic-ischemic injury in transgenic mice overexpressing Kir6.2 channel pore in forebrain.
Molecular and cellular neurosciences 2004;25(4):585-93.
2004: Haluzik Martin; Gavrilova Oksana; LeRoith Derek
Peroxisome proliferator-activated receptor-alpha deficiency does not alter insulin sensitivity in mice maintained on regular or high-fat diet: hyperinsulinemic-euglycemic clamp studies.
Endocrinology 2004;145(4):1662-7.
2004: LeRoith Derek; Helman Lee
The new kid on the block(ade) of the IGF-1 receptor.
Cancer cell 2004;5(3):201-2.
2004: LeRoith Derek; Levetan Claresa S; Hirsch Irl B; Riddle Matthew C
Type 2 diabetes: the role of basal insulin therapy.
The Journal of family practice 2004;53(3):215-22.
2004: LeRoith D
Non-islet cell hypoglycemia.
Annales d'endocrinologie 2004;65(1):99-103.
2004: Inoue Hiroshi; Ogawa Wataru; Ozaki Michitaka; Haga Sanae; Matsumoto Michihiro; Furukawa Kensuke; Hashimoto Naoko; Kido Yoshiaki; Mori Toshiyuki; Sakaue Hiroshi; Teshigawara Kiyoshi; Jin Shiyu; Iguchi Haruhisa; Hiramatsu Ryuji; LeRoith Derek; Takeda Kiyoshi; Akira Shizuo; Kasuga Masato
Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo.
Nature medicine 2004;10(2):168-74.
2004: Welniak Lisbeth A; Karas Michael; Yakar Shoshana; Anver Miriam R; Murphy William J; LeRoith Derek
Effects of organ-specific loss of insulin-like growth factor-I production on murine hematopoiesis.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2004;10(1):32-9.
2004: Zhao Hong; Dupont Joelle; Yakar Shoshana; Karas Michael; LeRoith Derek
PTEN inhibits cell proliferation and induces apoptosis by downregulating cell surface IGF-IR expression in prostate cancer cells.
Oncogene 2004;23(3):786-94.
2004: Yakar Shoshana; Setser Jennifer; Zhao Hong; Stannard Bethel; Haluzik Martin; Glatt Vaida; Bouxsein Mary L; Kopchick John J; LeRoith Derek
Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1-deficient mice.
The Journal of clinical investigation 2004;113(1):96-105.
2004: Smith Deirdre O; LeRoith Derek
Insulin resistance syndrome, pre-diabetes, and the prevention of type 2 diabetes mellitus.
Clinical cornerstone 2004;6(2):7-6.
2004: Yakar Shoshana; Pennisi Patricia; Zhao Hong; Zhang Yang; LeRoith Derek
Circulating IGF-1 and its role in cancer: lessons from the IGF-1 gene deletion (LID) mouse.
Novartis Foundation symposium 2004;262():3-9; discussion 9-18, 265-8.
2003: Kok Marc R; Yamano Seichii; Lodde Beatrijs M; Wang Jianghua; Couwenhoven Ross I; Yakar Shoshana; Voutetakis Antony; Leroith Derek; Schmidt Michael; Afione Sandra; Pillemer Stanley R; Tsutsui Marjorie T; Tak Paul P; Chiorini John A; Baum Bruce J
Local adeno-associated virus-mediated interleukin 10 gene transfer has disease-modifying effects in a murine model of Sjögren's syndrome.
Human gene therapy 2003;14(17):1605-18.
2003: Haluzik Martin; Yakar Shoshana; Gavrilova Oksana; Setser Jennifer; Boisclair Yves; LeRoith Derek
Insulin resistance in the liver-specific IGF-1 gene-deleted mouse is abrogated by deletion of the acid-labile subunit of the IGF-binding protein-3 complex: relative roles of growth hormone and IGF-1 in insulin resistance.
Diabetes 2003;52(10):2483-9.
2003: Bentov Itay; LeRoith Derek; Werner Haim
The WT1 Wilms' tumor suppressor gene: a novel target for insulin-like growth factor-I action.
Endocrinology 2003;144(10):4276-9.
2003: Mejia-Naranjo Wilson; Yakar Shoshana; Bernal Rosalina; LeRoith Derek; Sanchez-Gomez Myriam
Regulation of the splenic somatotropic axis by dietary protein and insulin-like growth factor-I in the rat.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 2003;13(5):254-63.
2003: LeRoith Derek; Smith Deirdre O
Loss of glucose homoeostasis: implications of basal glycaemia in type 2 diabetes.
Diabetes, obesity & metabolism 2003;5(5):285-94.
2003: Dupont Joëlle; Karas Michael; LeRoith Derek
The cyclin-dependent kinase inhibitor p21CIP/WAF is a positive regulator of insulin-like growth factor I-induced cell proliferation in MCF-7 human breast cancer cells.
The Journal of biological chemistry 2003;278(39):37256-64.
2003: Wu Yiping; Cui Karen; Miyoshi Keiko; Hennighausen Lothar; Green Jeffrey E; Setser Jennifer; LeRoith Derek; Yakar Shoshana
Reduced circulating insulin-like growth factor I levels delay the onset of chemically and genetically induced mammary tumors.
Cancer research 2003;63(15):4384-8.
2003: Kim Hyunsook; Haluzik Martin; Asghar Zeenat; Yau Daphne; Joseph Jamie W; Fernandez Ana M; Reitman Marc L; Yakar Shoshana; Stannard Bethel; Heron-Milhavet Lisa; Wheeler Michael B; LeRoith Derek
Peroxisome proliferator-activated receptor-alpha agonist treatment in a transgenic model of type 2 diabetes reverses the lipotoxic state and improves glucose homeostasis.
Diabetes 2003;52(7):1770-8.
2003: Yu Rong; Yakar Shoshana; Liu Ye Lauren; Lu Yarong; LeRoith Derek; Miao Dengshun; Liu Jun-Li
Liver-specific IGF-I gene deficient mice exhibit accelerated diabetes in response to streptozotocin, associated with early onset of insulin resistance.
Molecular and cellular endocrinology 2003;204(1-2):31-42.
2003: LeRoith Derek; Roberts Charles T
The insulin-like growth factor system and cancer.
Cancer letters 2003;195(2):127-37.
2003: Cefalu William T; LeRoith Derek;
Overcoming the barriers for achieving standards of diabetes care: the formation of CADRE.
Diabetes technology & therapeutics 2003;5(3):385-92.
2003: Dupont Joelle; Dunn Sandra E; Barrett J Carl; LeRoith Derek
Microarray analysis and identification of novel molecules involved in insulin-like growth factor-1 receptor signaling and gene expression.
Recent progress in hormone research 2003;58():325-42.
2002: Akintoye Sunday O; Chebli Caroline; Booher Susan; Feuillan Penelope; Kushner Harvey; Leroith Derek; Cherman Natasha; Bianco Paolo; Wientroub Shlomo; Robey Pamela Gehron; Collins Michael T
Characterization of gsp-mediated growth hormone excess in the context of McCune-Albright syndrome.
The Journal of clinical endocrinology and metabolism 2002;87(11):5104-12.
2002: LeRoith Derek
Beta-cell dysfunction and insulin resistance in type 2 diabetes: role of metabolic and genetic abnormalities.
The American journal of medicine 2002;113 Suppl 6A():3S-11S.
2002: Dupont Joëlle; Renou Jean Pierre; Shani Moshe; Hennighausen Lothar; LeRoith Derek
PTEN overexpression suppresses proliferation and differentiation and enhances apoptosis of the mouse mammary epithelium.
The Journal of clinical investigation 2002;110(6):815-25.
2002: Yakar Shoshana; Rosen Clifford J; Beamer Wesley G; Ackert-Bicknell Cheryl L; Wu Yiping; Liu Jun-Li; Ooi Guck T; Setser Jennifer; Frystyk Jan; Boisclair Yves R; LeRoith Derek
Circulating levels of IGF-1 directly regulate bone growth and density.
The Journal of clinical investigation 2002;110(6):771-81.
2002: Naranjo Wilson Mejia; Yakar Shoshana; Sanchez-Gomez Myriam; Perez Adriana Umana; Setser Jennifer; LERoith Derek
Protein calorie restriction affects nonhepatic IGF-I production and the lymphoid system: studies using the liver-specific IGF-I gene-deleted mouse model.
Endocrinology 2002;143(6):2233-41.
2002: Héron-Milhavet Lisa; LeRoith Derek
Insulin-like growth factor I induces MDM2-dependent degradation of p53 via the p38 MAPK pathway in response to DNA damage.
The Journal of biological chemistry 2002;277(18):15600-6.
2002: Butler Andrew A; Yakar Shoshana; LeRoith Derek
Insulin-like growth factor-I: compartmentalization within the somatotropic axis?
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society 2002;17():82-5.
2002: Wu Yiping; Yakar Shoshana; Zhao Ling; Hennighausen Lothar; LeRoith Derek
Circulating insulin-like growth factor-I levels regulate colon cancer growth and metastasis.
Cancer research 2002;62(4):1030-5.
2002: Burroughs K D; Howe S R; Okubo Y; Fuchs-Young R; LeRoith D; Walker C L
Dysregulation of IGF-I signaling in uterine leiomyoma.
The Journal of endocrinology 2002;172(1):83-93.
2001: Dupont J; Khan J; Qu B H; Metzler P; Helman L; LeRoith D
Insulin and IGF-1 induce different patterns of gene expression in mouse fibroblast NIH-3T3 cells: identification by cDNA microarray analysis.
Endocrinology 2001;142(11):4969-75.
2001: Jacobs A R; LeRoith D; Taylor S I
Insulin receptor substrate-1 pleckstrin homology and phosphotyrosine-binding domains are both involved in plasma membrane targeting.
The Journal of biological chemistry 2001;276(44):40795-802.
2001: Dupont J; Fernandez A M; Glackin C A; Helman L; LeRoith D
Insulin-like growth factor 1 (IGF-1)-induced twist expression is involved in the anti-apoptotic effects of the IGF-1 receptor.
The Journal of biological chemistry 2001;276(28):26699-707.
2001: Karas M; Koval A P; Zick Y; LeRoith D
The insulin-like growth factor I receptor-induced interaction of insulin receptor substrate-4 and Crk-II.
Endocrinology 2001;142(5):1835-40.
2001: Butler A A; LeRoith D
Minireview: tissue-specific versus generalized gene targeting of the igf1 and igf1r genes and their roles in insulin-like growth factor physiology.
Endocrinology 2001;142(5):1685-8.
2001: Héron-Milhavet L; Karas M; Goldsmith C M; Baum B J; LeRoith D
Insulin-like growth factor-I (IGF-I) receptor activation rescues UV-damaged cells through a p38 signaling pathway. Potential role of the IGF-I receptor in DNA repair.
The Journal of biological chemistry 2001;276(21):18185-92.
2001: Liu Y F; Paz K; Herschkovitz A; Alt A; Tennenbaum T; Sampson S R; Ohba M; Kuroki T; LeRoith D; Zick Y
Insulin stimulates PKCzeta -mediated phosphorylation of insulin receptor substrate-1 (IRS-1). A self-attenuated mechanism to negatively regulate the function of IRS proteins.
The Journal of biological chemistry 2001;276(17):14459-65.
2001: Hernández-Sánchez C; Basile A S; Fedorova I; Arima H; Stannard B; Fernandez A M; Ito Y; LeRoith D
Mice transgenically overexpressing sulfonylurea receptor 1 in forebrain resist seizure induction and excitotoxic neuron death.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(6):3549-54.
2001: Dupont J; LeRoith D
Insulin and insulin-like growth factor I receptors: similarities and differences in signal transduction.
Hormone research 2001;55 Suppl 2():22-6.
2000: Liu J L; Yakar S; LeRoith D
Mice deficient in liver production of insulin-like growth factor I display sexual dimorphism in growth hormone-stimulated postnatal growth.
Endocrinology 2000;141(12):4436-41.
2000: Dupont J; Karas M; LeRoith D
The potentiation of estrogen on insulin-like growth factor I action in MCF-7 human breast cancer cells includes cell cycle components.
The Journal of biological chemistry 2000;275(46):35893-901.
2000: Paz K; Boura-Halfon S; Wyatt L S; LeRoith D; Zick Y
The juxtamembrane but not the carboxyl-terminal domain of the insulin receptor mediates insulin's metabolic functions in primary adipocytes and cultured hepatoma cells.
Journal of molecular endocrinology 2000;24(3):419-32.
2000: Liu J L; Yakar S; LeRoith D
Conditional knockout of mouse insulin-like growth factor-1 gene using the Cre/loxP system.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 2000;223(4):344-51.
1999: Liu J L; LeRoith D
Insulin-like growth factor I is essential for postnatal growth in response to growth hormone.
Endocrinology 1999;140(11):5178-84.
1999: Qu B H; Karas M; Koval A; LeRoith D
Insulin receptor substrate-4 enhances insulin-like growth factor-I-induced cell proliferation.
The Journal of biological chemistry 1999;274(44):31179-84.
1999: Paz K; Liu Y F; Shorer H; Hemi R; LeRoith D; Quan M; Kanety H; Seger R; Zick Y
Phosphorylation of insulin receptor substrate-1 (IRS-1) by protein kinase B positively regulates IRS-1 function.
The Journal of biological chemistry 1999;274(40):28816-22.
1999: Yakar S; Liu J L; Stannard B; Butler A; Accili D; Sauer B; LeRoith D
Normal growth and development in the absence of hepatic insulin-like growth factor I.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(13):7324-9.
1999: Hernández-Sánchez C; Ito Y; Ferrer J; Reitman M; LeRoith D
Characterization of the mouse sulfonylurea receptor 1 promoter and its regulation.
The Journal of biological chemistry 1999;274(26):18261-70.
1998: Butler A A; Yakar S; Gewolb I H; Karas M; Okubo Y; LeRoith D
Insulin-like growth factor-I receptor signal transduction: at the interface between physiology and cell biology.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 1998;121(1):19-26.
1998: Liu J L; Grinberg A; Westphal H; Sauer B; Accili D; Karas M; LeRoith D
Insulin-like growth factor-I affects perinatal lethality and postnatal development in a gene dosage-dependent manner: manipulation using the Cre/loxP system in transgenic mice.
Molecular endocrinology (Baltimore, Md.) 1998;12(9):1452-62.
1998: Butler A A; Blakesley V A; Poulaki V; Tsokos M; Wood T L; LeRoith D;
Stimulation of tumor growth by recombinant human insulin-like growth factor-I (IGF-I) is dependent on the dose and the level of IGF-I receptor expression.
Cancer research 1998;58(14):3021-7.
1998: Blakesley V A; Koval A P; Stannard B S; Scrimgeour A; LeRoith D
Replacement of tyrosine 1251 in the carboxyl terminus of the insulin-like growth factor-I receptor disrupts the actin cytoskeleton and inhibits proliferation and anchorage-independent growth.
The Journal of biological chemistry 1998;273(29):18411-22.
1998: Koval A P; Karas M; Zick Y; LeRoith D
Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth factor-I receptor-mediated signal transduction.
The Journal of biological chemistry 1998;273(24):14780-7.
1998: Kalebic T; Blakesley V; Slade C; Plasschaert S; Leroith D; Helman L J
Expression of a kinase-deficient IGF-I-R suppresses tumorigenicity of rhabdomyosarcoma cells constitutively expressing a wild type IGF-I-R.
International journal of cancer. Journal international du cancer 1998;76(2):223-7.
1998: Ohlsson C; Kley N; Werner H; LeRoith D
p53 regulates insulin-like growth factor-I (IGF-I) receptor expression and IGF-I-induced tyrosine phosphorylation in an osteosarcoma cell line: interaction between p53 and Sp1.
Endocrinology 1998;139(3):1101-7.
1998: Koval A P; Blakesley V A; Roberts C T; Zick Y; Leroith D
Interaction in vitro of the product of the c-Crk-II proto-oncogene with the insulin-like growth factor I receptor.
The Biochemical journal 1998;330 ( Pt 2)():923-32.
1998: Landau D; Domene H; Flyvbjerg A; Grønbaek H; Roberts C T; Argov S; LeRoith D
Differential expression of renal growth hormone receptor and its binding protein in experimental diabetes mellitus.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 1998;8(1):39-45.
1998: Li S; Termini J; Hayward A; Siddle K; Zick Y; Koval A; LeRoith D; Fujita-Yamaguchi Y
The carboxyl-terminal domain of insulin-like growth factor-I receptor interacts with the insulin receptor and activates its protein tyrosine kinase.
FEBS letters 1998;421(1):45-9.
1997: Toretsky J A; Kalebic T; Blakesley V; LeRoith D; Helman L J
The insulin-like growth factor-I receptor is required for EWS/FLI-1 transformation of fibroblasts.
The Journal of biological chemistry 1997;272(49):30822-7.
1997: Paz K; Hemi R; LeRoith D; Karasik A; Elhanany E; Kanety H; Zick Y
A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation.
The Journal of biological chemistry 1997;272(47):29911-8.
1997: Liu J L; Blakesley V A; Gutkind J S; LeRoith D
The constitutively active mutant Galpha13 transforms mouse fibroblast cells deficient in insulin-like growth factor-I receptor.
The Journal of biological chemistry 1997;272(47):29438-41.
1997: Butler A A; Blakesley V A; Koval A; deJong R; Groffen J; LeRoith D
In vivo regulation of CrkII and CrkL proto-oncogenes in the uterus by insulin-like growth factor-I. Differential effects on tyrosine phosphorylation and association with paxillin.
The Journal of biological chemistry 1997;272(44):27660-4.
1997: Ng S T; Zhou J; Adesanya O O; Wang J; LeRoith D; Bondy C A
Growth hormone treatment induces mammary gland hyperplasia in aging primates.
Nature medicine 1997;3(10):1141-4.
1997: Esposito D L; Blakesley V A; Koval A P; Scrimgeour A G; LeRoith D
Tyrosine residues in the C-terminal domain of the insulin-like growth factor-I receptor mediate mitogenic and tumorigenic signals.
Endocrinology 1997;138(7):2979-88.
1997: Blakesley V A; Beitner-Johnson D; Van Brocklyn J R; Rani S; Shen-Orr Z; Stannard B S; Spiegel S; LeRoith D
Sphingosine 1-phosphate stimulates tyrosine phosphorylation of Crk.
The Journal of biological chemistry 1997;272(26):16211-5.
1997: Scrimgeour A G; Blakesley V A; Stannard B S; LeRoith D
Mitogen-activated protein kinase and phosphatidylinositol 3-kinase pathways are not sufficient for insulin-like growth factor I-induced mitogenesis and tumorigenesis.
Endocrinology 1997;138(6):2552-8.
1997: Párrizas M; Gazit A; Levitzki A; Wertheimer E; LeRoith D
Specific inhibition of insulin-like growth factor-1 and insulin receptor tyrosine kinase activity and biological function by tyrphostins.
Endocrinology 1997;138(4):1427-33.
1997: Blakesley V A; Stannard B S; Kalebic T; Helman L J; LeRoith D
Role of the IGF-I receptor in mutagenesis and tumor promotion.
The Journal of endocrinology 1997;152(3):339-44.
1997: Párrizas M; LeRoith D
Insulin-like growth factor-1 inhibition of apoptosis is associated with increased expression of the bcl-xL gene product.
Endocrinology 1997;138(3):1355-8.
1997: Chin E; Zamah A M; Landau D; Grønbcek H; Flyvbjerg A; LeRoith D; Bondy C A
Changes in facilitative glucose transporter messenger ribonucleic acid levels in the diabetic rat kidney.
Endocrinology 1997;138(3):1267-75.
1997: Hernández-Sánchez C; Werner H; Roberts C T; Woo E J; Hum D W; Rosenthal S M; LeRoith D
Differential regulation of insulin-like growth factor-I (IGF-I) receptor gene expression by IGF-I and basic fibroblastic growth factor.
The Journal of biological chemistry 1997;272(8):4663-70.
1997: Hernández-Sánchez C; Wood T L; LeRoith D
Developmental and tissue-specific sulfonylurea receptor gene expression.
Endocrinology 1997;138(2):705-11.
1997: Párrizas M; Saltiel A R; LeRoith D
Insulin-like growth factor 1 inhibits apoptosis using the phosphatidylinositol 3'-kinase and mitogen-activated protein kinase pathways.
The Journal of biological chemistry 1997;272(1):154-61.
1996: Werner H; Karnieli E; Rauscher F J; LeRoith D
Wild-type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptor gene.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(16):8318-23.
1996: Karnieli E; Werner H; Rauscher F J; Benjamin L E; LeRoith D
The IGF-I receptor gene promoter is a molecular target for the Ewing's sarcoma-Wilms' tumor 1 fusion protein.
The Journal of biological chemistry 1996;271(32):19304-9.
1996: Neuenschwander S; Schwartz A; Wood T L; Roberts C T; Hennighausen L; LeRoith D
Involution of the lactating mammary gland is inhibited by the IGF system in a transgenic mouse model.
The Journal of clinical investigation 1996;97(10):2225-32.
1996: Beitner-Johnson D; Blakesley V A; Shen-Orr Z; Jimenez M; Stannard B; Wang L M; Pierce J; LeRoith D
The proto-oncogene product c-Crk associates with insulin receptor substrate-1 and 4PS. Modulation by insulin growth factor-I (IGF) and enhanced IGF-I signaling.
The Journal of biological chemistry 1996;271(16):9287-90.
1996: Paz K; Voliovitch H; Hadari Y R; Roberts C T; LeRoith D; Zick Y
Interaction between the insulin receptor and its downstream effectors. Use of individually expressed receptor domains for structure/function analysis.
The Journal of biological chemistry 1996;271(12):6998-7003.
1996: LeRoith D; Yanowski J; Kaldjian E P; Jaffe E S; LeRoith T; Purdue K; Cooper B D; Pyle R; Adler W
The effects of growth hormone and insulin-like growth factor I on the immune system of aged female monkeys.
Endocrinology 1996;137(3):1071-9.
1996: Blakesley V A; Kalebic T; Helman L J; Stannard B; Faria T N; Roberts C T; LeRoith D
Tumorigenic and mitogenic capacities are reduced in transfected fibroblasts expressing mutant insulin-like growth factor (IGF)-I receptors. The role of tyrosine residues 1250, 1251, and 1316 in the carboxy-terminus of the IGF-I receptor.
Endocrinology 1996;137(2):410-7.
1996: LeRoith D
Insulin-like growth factor receptors and binding proteins.
Baillière's clinical endocrinology and metabolism 1996;10(1):49-73.
1996: Werner H; Roberts C T; Rauscher F J; LeRoith D
Regulation of insulin-like growth factor I receptor gene expression by the Wilms' tumor suppressor WT1.
Journal of molecular neuroscience : MN 1996;7(2):111-23.
1996: Werner H; LeRoith D
The role of the insulin-like growth factor system in human cancer.
Advances in cancer research 1996;68():183-223.
1995: Hernández-Sánchez C; Blakesley V; Kalebic T; Helman L; LeRoith D
The role of the tyrosine kinase domain of the insulin-like growth factor-I receptor in intracellular signaling, cellular proliferation, and tumorigenesis.
The Journal of biological chemistry 1995;270(49):29176-81.
1995: Stannard B; Blakesley V; Kato H; Roberts C T; LeRoith D
Single tyrosine substitution in the insulin-like growth factor I receptor inhibits ligand-induced receptor autophosphorylation and internalization, but not mitogenesis.
Endocrinology 1995;136(11):4918-24.
1995: Yang H; Adamo M L; Koval A P; McGuinness M C; Ben-Hur H; Yang Y; LeRoith D; Roberts C T
Alternative leader sequences in insulin-like growth factor I mRNAs modulate translational efficiency and encode multiple signal peptides.
Molecular endocrinology (Baltimore, Md.) 1995;9(10):1380-95.
1995: Neuenschwander S; Roberts C T; LeRoith D
Growth inhibition of MCF-7 breast cancer cells by stable expression of an insulin-like growth factor I receptor antisense ribonucleic acid.
Endocrinology 1995;136(10):4298-303.
1995: Werner H; Hernández-Sánchez C; Karnieli E; Leroith D
The regulation of IGF-I receptor gene expression.
The international journal of biochemistry & cell biology 1995;27(10):987-94.
1995: Flyvbjerg A; Landau D; Domene H; Hernandez L; Grønbaek H; LeRoith D
The role of growth hormone, insulin-like growth factors (IGFs), and IGF-binding proteins in experimental diabetic kidney disease.
Metabolism: clinical and experimental 1995;44(10 Suppl 4):67-71.
1995: Beitner-Johnson D; Werner H; Roberts C T; LeRoith D
Regulation of insulin-like growth factor I receptor gene expression by Sp1: physical and functional interactions of Sp1 at GC boxes and at a CT element.
Molecular endocrinology (Baltimore, Md.) 1995;9(9):1147-56.
1995: LeRoith D; Werner H; Neuenschwander S; Kalebic T; Helman L J
The role of the insulin-like growth factor-I receptor in cancer.
Annals of the New York Academy of Sciences 1995;766():402-8.
1995: Werner H; Shen-Orr Z; Rauscher F J; Morris J F; Roberts C T; LeRoith D
Inhibition of cellular proliferation by the Wilms' tumor suppressor WT1 is associated with suppression of insulin-like growth factor I receptor gene expression.
Molecular and cellular biology 1995;15(7):3516-22.
1995: Landau D; Chin E; Bondy C; Domene H; Roberts C T; Gronbaek H; Flyvbjerg A; LeRoith D
Expression of insulin-like growth factor binding proteins in the rat kidney: effects of long-term diabetes.
Endocrinology 1995;136(5):1835-42.
1995: Malozowski S; Parmer T G; Trojan S; Merriam G R; Gibori G; Roberts C T; LeRoith D; Werner H; Zilberstein M
Growth hormone (GH) modulates insulin-like growth factor I (IGF-I) and type I IGF receptor mRNA levels in the ovary of prepubertal GH-deficient rats.
European journal of endocrinology / European Federation of Endocrine Societies 1995;132(4):497-501.
1995: LeRoith D; Werner H; Beitner-Johnson D; Roberts C T
Molecular and cellular aspects of the insulin-like growth factor I receptor.
Endocrine reviews 1995;16(2):143-63.
1995: Domené H M; Cassorla F; Werner H; Roberts C T; Leroith D
Rat growth hormone receptor/growth hormone-binding protein mRNAs with divergent 5'-untranslated regions are expressed in a tissue-specific manner.
DNA and cell biology 1995;14(3):195-204.
1995: Beitner-Johnson D; LeRoith D
Insulin-like growth factor-I stimulates tyrosine phosphorylation of endogenous c-Crk.
The Journal of biological chemistry 1995;270(10):5187-90.
1995: Blakesley V A; Kato H; Roberts C T; LeRoith D
Mutation of a conserved amino acid residue (tryptophan 1173) in the tyrosine kinase domain of the IGF-I receptor abolishes autophosphorylation but does not eliminate biologic function.
The Journal of biological chemistry 1995;270(6):2764-9.
1995: LeRoith D; Baserga R; Helman L; Roberts C T
Insulin-like growth factors and cancer.
Annals of internal medicine 1995;122(1):54-9.
1995: LeRoith D; Neuenschwander S; Wood T L; Hennighausen L
Insulin-like growth factor-I and insulin-like growth factor binding protein-3 inhibit involution of the mammary gland following lactation: studies in transgenic mice.
Progress in growth factor research 1995;6(2-4):433-6.
1994: Koval A; Kulik V; Duguay S; Plisetskaya E; Adamo M L; Roberts C T; Leroith D; Kavsan V
Characterization of a salmon insulin-like growth factor I promoter.
DNA and cell biology 1994;13(10):1057-62.
1994: Bikle D D; Harris J; Halloran B P; Roberts C T; Leroith D; Morey-Holton E
Expression of the genes for insulin-like growth factors and their receptors in bone during skeletal growth.
The American journal of physiology 1994;267(2 Pt 1):E278-86.
1994: Yakar S; Domene H; Meidan R; Cassorla F; Gilad I; Koch I; Laron Z; Roberts C T; LeRoith D; Eshet R
Growth hormone (GH) stimulates insulin-like growth factor-I (IGF-I) and IGF-binding protein (IGFBP)-2 gene expression in spleens of juvenile rats.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1994;26(8):363-6.
1994: Domené H M; Meidan R; Yakar S; Shen-Orr Z; Cassorla F; Roberts C T; LeRoith D
Role of GH and IGF-I in the regulation of IGF-I, IGF-I receptor and IGF binding protein gene expression in the rat spleen.
Regulatory peptides 1994;52(3):215-26.
1994: Faria T N; Blakesley V A; Kato H; Stannard B; LeRoith D; Roberts C T
Role of the carboxyl-terminal domains of the insulin and insulin-like growth factor I receptors in receptor function.
The Journal of biological chemistry 1994;269(19):13922-8.
1994: Kavsan V M; Grebenjuk V A; Koval A P; Skorokhod A S; Roberts C T; Leroith D
Isolation of a second nonallelic insulin-like growth factor I gene from the salmon genome.
DNA and cell biology 1994;13(5):555-9.
1994: Werner H; Rauscher F J; Sukhatme V P; Drummond I A; Roberts C T; LeRoith D
Transcriptional repression of the insulin-like growth factor I receptor (IGF-I-R) gene by the tumor suppressor WT1 involves binding to sequences both upstream and downstream of the IGF-I-R gene transcription start site.
The Journal of biological chemistry 1994;269(17):12577-82.
1994: Nadiv O; Shinitzky M; Manu H; Hecht D; Roberts C T; LeRoith D; Zick Y
Elevated protein tyrosine phosphatase activity and increased membrane viscosity are associated with impaired activation of the insulin receptor kinase in old rats.
The Biochemical journal 1994;298 ( Pt 2)():443-50.
1994: Kato H; Faria T N; Stannard B; Roberts C T; LeRoith D
Essential role of tyrosine residues 1131, 1135, and 1136 of the insulin-like growth factor-I (IGF-I) receptor in IGF-I action.
Molecular endocrinology (Baltimore, Md.) 1994;8(1):40-50.
1994: LeRoith D; Sampson P C; Roberts C T
How does the mitogenic insulin-like growth factor I receptor differ from the metabolic insulin receptor?
Hormone research 1994;41 Suppl 2():74-8; discussion 79.
1994: Werner H; Adamo M; Roberts C T; LeRoith D
Molecular and cellular aspects of insulin-like growth factor action.
Vitamins and hormones 1994;48():1-58.
1993: LeRoith D; Werner H; Phillip M; Roberts C T
The role of insulin-like growth factors in diabetic kidney disease.
American journal of kidney diseases : the official journal of the National Kidney Foundation 1993;22(5):722-6.
1993: Hadari Y R; Geiger B; Nadiv O; Sabanay I; Roberts C T; LeRoith D; Zick Y
Hepatic tyrosine-phosphorylated proteins identified and localized following in vivo inhibition of protein tyrosine phosphatases: effects of H2O2 and vanadate administration into rat livers.
Molecular and cellular endocrinology 1993;97(1-2):9-17.
1993: Shemer J; Yaron A; Werner H; Shao Z M; Sheikh M S; Fontana J A; LeRoith D; Roberts C T
Regulation of insulin-like growth factor (IGF) binding protein-5 in the T47D human breast carcinoma cell line by IGF-I and retinoic acid.
The Journal of clinical endocrinology and metabolism 1993;77(5):1246-50.
1993: Kavsan V M; Koval A P; Grebenjuk V A; Chan S J; Steiner D F; Roberts C T; LeRoith D
Structure of the chum salmon insulin-like growth factor I gene.
DNA and cell biology 1993;12(8):729-37.
1993: LeRoith D; Kavsan V M; Koval A P; Roberts C T
Phylogeny of the insulin-like growth factors (IGFs) and receptors: a molecular approach.
Molecular reproduction and development 1993;35(4):332-6; discussion 337-8.
1993: LeRoith D; Roberts C T
Insulin-like growth factors.
Annals of the New York Academy of Sciences 1993;692():1-9.
1993: LeRoith D; Werner H; Faria T N; Kato H; Adamo M; Roberts C T
Insulin-like growth factor receptors. Implications for nervous system function.
Annals of the New York Academy of Sciences 1993;692():22-32.
1993: Adamo M L; Shemer J; Roberts C T; LeRoith D
Insulin and insulin-like growth factor-I induced phosphorylation in neurally derived cells.
Annals of the New York Academy of Sciences 1993;692():113-25.
1993: Domené H; Krishnamurthi K; Eshet R; Gilad I; Laron Z; Koch I; Stannard B; Cassorla F; Roberts C T; LeRoith D
Growth hormone (GH) stimulates insulin-like growth factor-I (IGF-I) and IGF-I-binding protein-3, but not GH receptor gene expression in livers of juvenile rats.
Endocrinology 1993;133(2):675-82.
1993: LeRoith D; Roberts C T
Insulin-like growth factors and their receptors in normal physiology and pathological states.
The Journal of pediatric endocrinology 1993;6(3-4):251-5.
1993: Kato H; Faria T N; Stannard B; Levy-Toledano R; Taylor S I; Roberts C T; LeRoith D
Paradoxical biological effects of overexpressed insulin-like growth factor-1 receptors in Chinese hamster ovary cells.
Journal of cellular physiology 1993;156(1):145-52.
1993: Woloschak M; Shen-Orr Z; LeRoith D; Roberts C T
Nutritional regulation of insulin-sensitive glucose transporter gene expression in rat cardiac muscle.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1993;203(2):172-4.
1993: Werner H; Re G G; Drummond I A; Sukhatme V P; Rauscher F J; Sens D A; Garvin A J; LeRoith D; Roberts C T
Increased expression of the insulin-like growth factor I receptor gene, IGF1R, in Wilms tumor is correlated with modulation of IGF1R promoter activity by the WT1 Wilms tumor gene product.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(12):5828-32.
1993: Kavsan V; Koval A; Petrenko O; Roberts C T; LeRoith D
Two insulin genes are present in the salmon genome.
Biochemical and biophysical research communications 1993;191(3):1373-8.
1993: LeRoith D; Adamo M L; Shemer J; Lanau F; Shen-Orr Z; Yaron A; Roberts C T; Clemmons D R; Sheikh M S; Shao Z M
Retinoic acid inhibits growth of breast cancer cell lines: the role of insulin-like growth factor binding proteins.
Growth regulation 1993;3(1):78-80.
1993: Adamo M L; Lanau F; Neuenschwander S; Werner H; LeRoith D; Roberts C T
Distinct promoters in the rat insulin-like growth factor-I (IGF-I) gene are active in CHO cells.
Endocrinology 1993;132(2):935-7.
1993: Kato H; Faria T N; Stannard B; Roberts C T; LeRoith D
Role of tyrosine kinase activity in signal transduction by the insulin-like growth factor-I (IGF-I) receptor. Characterization of kinase-deficient IGF-I receptors and the action of an IGF-I-mimetic antibody (alpha IR-3).
The Journal of biological chemistry 1993;268(4):2655-61.
1993: Werner H; Roberts C T; LeRoith D
The regulation of IGF-I receptor gene expression by positive and negative zinc-finger transcription factors.
Advances in experimental medicine and biology 1993;343():91-103.
1992: Shemer J; Adamo M L; Roberts C T; LeRoith D
Tissue-specific transcription start site usage in the leader exons of the rat insulin-like growth factor-I gene: evidence for differential regulation in the developing kidney.
Endocrinology 1992;131(6):2793-9.
1992: Foyt H L; Lanau F; Woloschak M; LeRoith D; Roberts C T
Effect of growth hormone on levels of differentially processed insulin-like growth factor I mRNAs in total and polysomal mRNA populations.
Molecular endocrinology (Baltimore, Md.) 1992;6(11):1881-8.
1992: Werner H; Bach M A; Stannard B; Roberts C T; LeRoith D
Structural and functional analysis of the insulin-like growth factor I receptor gene promoter.
Molecular endocrinology (Baltimore, Md.) 1992;6(10):1545-58.
1992: Adamo M L; Shao Z M; Lanau F; Chen J C; Clemmons D R; Roberts C T; LeRoith D; Fontana J A
Insulin-like growth factor-I (IGF-I) and retinoic acid modulation of IGF-binding proteins (IGFBPs): IGFBP-2, -3, and -4 gene expression and protein secretion in a breast cancer cell line.
Endocrinology 1992;131(4):1858-66.
1992: Hadari Y R; Tzahar E; Nadiv O; Rothenberg P; Roberts C T; LeRoith D; Yarden Y; Zick Y
Insulin and insulinomimetic agents induce activation of phosphatidylinositol 3'-kinase upon its association with pp185 (IRS-1) in intact rat livers.
The Journal of biological chemistry 1992;267(25):17483-6.
1992: Levy M J; Hernandez E R; Adashi E Y; Stillman R J; Roberts C T; LeRoith D
Expression of the insulin-like growth factor (IGF)-I and -II and the IGF-I and -II receptor genes during postnatal development of the rat ovary.
Endocrinology 1992;131(3):1202-6.
1992: LeRoith D; McGuinness M; Shemer J; Stannard B; Lanau F; Faria T N; Kato H; Werner H; Adamo M; Roberts C T
Insulin-like growth factors.
Biological signals 1992;1(4):173-81.
1992: Sklar M M; Thomas C L; Municchi G; Roberts C T; LeRoith D; Kiess W; Nissley P
Developmental expression of rat insulin-like growth factor-II/mannose 6-phosphate receptor messenger ribonucleic acid.
Endocrinology 1992;130(6):3484-91.
1992: LeRoith D; Clemmons D; Nissley P; Rechler M M
NIH conference. Insulin-like growth factors in health and disease.
Annals of internal medicine 1992;116(10):854-62.
1992: Adamo M; Roberts C T; LeRoith D
How distinct are the insulin and insulin-like growth factor I signalling systems?
BioFactors (Oxford, England) 1992;3(3):151-7.
1992: Bondy C; Werner H; Roberts C T; LeRoith D
Cellular pattern of type-I insulin-like growth factor receptor gene expression during maturation of the rat brain: comparison with insulin-like growth factors I and II.
Neuroscience 1992;46(4):909-23.
1992: LeRoith D; Shemer J; Roberts C T
Evolutionary origins of intercellular communication systems: implications for mammalian biology.
Hormone research 1992;38 Suppl 2():1-6.
1992: LeRoith D; Werner H; Burguera B; Roberts C T; Mulroney S; Haramati A
The insulin-like growth factor family of peptides, binding proteins and receptors: their potential role in tissue regeneration.
Advances in experimental medicine and biology 1992;321():21-8; discussion 29-30.
1991: Parmer T G; Roberts C T; LeRoith D; Adashi E Y; Khan I; Solan N; Nelson S; Zilberstein M; Gibori G
Expression, action, and steroidal regulation of insulin-like growth factor-I (IGF-I) and IGF-I receptor in the rat corpus luteum: their differential role in the two cell populations forming the corpus luteum.
Endocrinology 1991;129(6):2924-32.
1991: Adamo M L; Ben-Hur H; Roberts C T; LeRoith D
Regulation of start site usage in the leader exons of the rat insulin-like growth factor-I gene by development, fasting, and diabetes.
Molecular endocrinology (Baltimore, Md.) 1991;5(11):1677-86.
1991: Waldbillig R J; Pfeffer B A; Schoen T J; Adler A A; Shen-Orr Z; Scavo L; LeRoith D; Chader G J
Evidence for an insulin-like growth factor autocrine-paracrine system in the retinal photoreceptor-pigment epithelial cell complex.
Journal of neurochemistry 1991;57(5):1522-33.
1991: Adamo M L; Ben-Hur H; LeRoith D; Roberts C T
Transcription initiation in the two leader exons of the rat IGF-I gene occurs from disperse versus localized sites.
Biochemical and biophysical research communications 1991;176(2):887-93.
1991: Foyt H L; LeRoith D; Roberts C T
Differential association of insulin-like growth factor I mRNA variants with polysomes in vivo.
The Journal of biological chemistry 1991;266(11):7300-5.
1991: Bach M A; Shen-Orr Z; Lowe W L; Roberts C T; LeRoith D
Insulin-like growth factor I mRNA levels are developmentally regulated in specific regions of the rat brain.
Brain research. Molecular brain research 1991;10(1):43-8.
1991: Werner H; Stannard B; Bach M A; Roberts C T; LeRoith D
Regulation of insulin-like growth factor I receptor gene expression in normal and pathological states.
Advances in experimental medicine and biology 1991;293():263-72.
1990: Werner H; Shen-Orr Z; Stannard B; Burguera B; Roberts C T; LeRoith D
Experimental diabetes increases insulinlike growth factor I and II receptor concentration and gene expression in kidney.
Diabetes 1990;39(12):1490-7.
1990: Burguera B; Werner H; Sklar M; Shen-Orr Z; Stannard B; Roberts C T; Nissley S P; Vore S J; Caro J F; LeRoith D
Liver regeneration is associated with increased expression of the insulin-like growth factor-II/mannose-6-phosphate receptor.
Molecular endocrinology (Baltimore, Md.) 1990;4(10):1539-45.
1990: Serrano J; Shuldiner A R; Roberts C T; LeRoith D; de Pablo F
The insulin-like growth factor I (IGF-I) gene is expressed in chick embryos during early organogenesis.
Endocrinology 1990;127(3):1547-9.
1990: Bondy C A; Werner H; Roberts C T; LeRoith D
Cellular pattern of insulin-like growth factor-I (IGF-I) and type I IGF receptor gene expression in early organogenesis: comparison with IGF-II gene expression.
Molecular endocrinology (Baltimore, Md.) 1990;4(9):1386-98.
1990: Bach M A; Roberts C T; Smith E P; LeRoith D
Alternative splicing produces messenger RNAs encoding insulin-like growth factor-I prohormones that are differentially glycosylated in vitro.
Molecular endocrinology (Baltimore, Md.) 1990;4(6):899-904.
1990: Werner H; Stannard B; Bach M A; LeRoith D; Roberts C T
Cloning and characterization of the proximal promoter region of the rat insulin-like growth factor I (IGF-I) receptor gene.
Biochemical and biophysical research communications 1990;169(3):1021-7.
1989: Lowe W L; Roberts C T; LeRoith D; Rojeski M T; Merimee T J; Fui S T; Keen H; Arnold D; Mersey J; Gluzman S
Insulin-like growth factor-II in nonislet cell tumors associated with hypoglycemia: increased levels of messenger ribonucleic acid.
The Journal of clinical endocrinology and metabolism 1989;69(6):1153-9.
1989: Ota A; Shen-Orr Z; LeRoith D
Insulin and IGF-I receptors in neuroblastoma cells: increases in mRNA and binding produced by glyburide.
Neuropeptides 1989;14(3):171-5.
1989: Werner H; Woloschak M; Adamo M; Shen-Orr Z; Roberts C T; LeRoith D
Developmental regulation of the rat insulin-like growth factor I receptor gene.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(19):7451-5.
1989: Zilberstein M; Chou J Y; Lowe W L; Shen-Orr Z; Roberts C T; LeRoith D; Catt K J
Expression of insulin-like growth factor-I and its receptor by SV40-transformed rat granulosa cells.
Molecular endocrinology (Baltimore, Md.) 1989;3(9):1488-97.
1989: Lowe W L; Adamo M; LeRoith D; Roberts C T
Expression and stability of insulin-like growth factor-I (IGF-I) mRNA splicing variants in the GH3 rat pituitary cell line.
Biochemical and biophysical research communications 1989;162(3):1174-9.
1989: Lowe W L; Adamo M; Werner H; Roberts C T; LeRoith D
Regulation by fasting of rat insulin-like growth factor I and its receptor. Effects on gene expression and binding.
The Journal of clinical investigation 1989;84(2):619-26.
1989: Ota A; Shen-Orr Z; Roberts C T; LeRoith D
TPA-induced neurite formation in a neuroblastoma cell line (SH-SY5Y) is associated with increased IGF-I receptor mRNA and binding.
Brain research. Molecular brain research 1989;6(1):69-76.
1989: Werner H; Raizada M K; Mudd L M; Foyt H L; Simpson I A; Roberts C T; LeRoith D
Regulation of rat brain/HepG2 glucose transporter gene expression by insulin and insulin-like growth factor-I in primary cultures of neuronal and glial cells.
Endocrinology 1989;125(1):314-20.
1989: Shuldiner A R; Phillips S; Roberts C T; LeRoith D; Roth J
Xenopus laevis contains two nonallelic preproinsulin genes. cDNA cloning and evolutionary perspective.
The Journal of biological chemistry 1989;264(16):9428-32.
1989: Adamo M; Lowe W L; LeRoith D; Roberts C T
Insulin-like growth factor I messenger ribonucleic acids with alternative 5'-untranslated regions are differentially expressed during development of the rat.
Endocrinology 1989;124(6):2737-44.
1989: Adamo M; Shemer J; Aridor M; Dixon J; Carswell N; Bhathena S J; Michaelis O E; LeRoith D
Liver insulin receptor tyrosine kinase activity in a rat model of type II diabetes mellitus and obesity.
The Journal of nutrition 1989;119(3):484-9.
1989: Werner H; Adamo M; Lowe W L; Roberts C T; LeRoith D
Developmental regulation of rat brain/Hep G2 glucose transporter gene expression.
Molecular endocrinology (Baltimore, Md.) 1989;3(2):273-9.
1989: Shemer J; Adamo M; Raizada M K; Heffez D; Zick Y; LeRoith D
Insulin and IGF-I stimulate phosphorylation of their respective receptors in intact neuronal and glial cells in primary culture.
Journal of molecular neuroscience : MN 1989;1(1):3-8.
1989: Adamo M; Raizada M K; LeRoith D
Insulin and insulin-like growth factor receptors in the nervous system.
Molecular neurobiology 1989;3(1-2):71-100.
1988: Adamo M; Werner H; Farnsworth W; Roberts C T; Raizada M; LeRoith D
Dexamethasone reduces steady state insulin-like growth factor I messenger ribonucleic acid levels in rat neuronal and glial cells in primary culture.
Endocrinology 1988;123(5):2565-70.
1988: LeRoith D; Adamo M; Shemer J; Waldbillig R; Lesniak M A; dePablo F; Hart C; Roth J
Insulin-related materials in the nervous system of vertebrates and non-vertebrates: possible extrapancreatic production.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1988;20(7):411-20.
1988: Shemer J; Ota A; Adamo M; LeRoith D
Insulin-sensitive tyrosine kinase is increased in livers of adult obese Zucker rats: correction with prolonged fasting.
Endocrinology 1988;123(1):140-8.
1988: Lowe W L; Lasky S R; LeRoith D; Roberts C T
Distribution and regulation of rat insulin-like growth factor I messenger ribonucleic acids encoding alternative carboxyterminal E-peptides: evidence for differential processing and regulation in liver.
Molecular endocrinology (Baltimore, Md.) 1988;2(6):528-35.
1988: Ota A; Wilson G L; Leroith D
Insulin-like growth factor I receptors on mouse neuroblastoma cells. Two beta subunits are derived from differences in glycosylation.
European journal of biochemistry / FEBS 1988;174(3):521-30.
1988: Ota A; Shemer J; Pruss R M; Lowe W L; LeRoith D
Characterization of the altered oligosaccharide composition of the insulin receptor on neural-derived cells.
Brain research 1988;443(1-2):1-11.
1988: Rodrigues M; Waldbillig R J; Rajagopalan S; Hackett J; LeRoith D; Chader G J
Retinal insulin receptors: localization using a polyclonal anti-insulin receptor antibody.
Brain research 1988;443(1-2):389-94.
1988: Ota A; Wilson G L; Spilberg O; Pruss R; LeRoith D
Functional insulin-like growth factor I receptors are expressed by neural-derived continuous cell lines.
Endocrinology 1988;122(1):145-52.
1988: LeRoith D; Lowe W L; Shemer J; Raizada M K; Ota A
Development of brain insulin receptors.
The International journal of biochemistry 1988;20(3):225-30.
1988: Adamo M; LeRoith D; Simon J; Roth J
Effect of altered nutritional states on insulin receptors.
Annual review of nutrition 1988;8():149-66.
1987: Lowe W L; Roberts C T; Lasky S R; LeRoith D
Differential expression of alternative 5' untranslated regions in mRNAs encoding rat insulin-like growth factor I.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(24):8946-50.
1987: Adamo M; Simon J; Rosebrough R W; McMurtry J P; Steele N C; LeRoith D
Characterization of the chicken muscle insulin receptor.
General and comparative endocrinology 1987;68(3):456-65.
1987: Waldbillig R J; Fletcher R T; Chader G J; Rajagopalan S; Rodrigues M; LeRoith D
Retinal insulin receptors. 2. Characterization and insulin-induced tyrosine kinase activity in bovine retinal rod outer segments.
Experimental eye research 1987;45(6):837-44.
1987: Waldbillig R J; Fletcher R T; Chader G J; Rajagopalan S; Rodrigues M; LeRoith D
Retinal insulin receptors. 1. Structural heterogeneity and functional characterization.
Experimental eye research 1987;45(6):823-35.
1987: Hart C; Shemer J; Penhos J C; Lesniak M A; Roth J; LeRoith D
Frog brain and liver show evolutionary conservation of tissue-specific differences among insulin receptors.
General and comparative endocrinology 1987;68(2):170-8.
1987: Shemer J; Adamo M; Wilson G L; Heffez D; Zick Y; LeRoith D
Insulin and insulin-like growth factor-I stimulate a common endogenous phosphoprotein substrate (pp185) in intact neuroblastoma cells.
The Journal of biological chemistry 1987;262(32):15476-82.
1987: Roberts C T; Lasky S R; Lowe W L; LeRoith D
Rat IGF-I cDNA's contain multiple 5'-untranslated regions.
Biochemical and biophysical research communications 1987;146(3):1154-9.
1987: Roberts C T; Lasky S R; Lowe W L; Seaman W T; LeRoith D
Molecular cloning of rat insulin-like growth factor I complementary deoxyribonucleic acids: differential messenger ribonucleic acid processing and regulation by growth hormone in extrahepatic tissues.
Molecular endocrinology (Baltimore, Md.) 1987;1(3):243-8.
1987: Lowe W L; Schaffner A E; Roberts C T; LeRoith D
Developmental regulation of somatostatin gene expression in the brain is region specific.
Molecular endocrinology (Baltimore, Md.) 1987;1(2):181-7.
1986: LeRoith D; Delahunty G; Wilson G L; Roberts C T; Shemer J; Hart C; Lesniak M A; Shiloach J; Roth J
Evolutionary aspects of the endocrine and nervous systems.
Recent progress in hormone research 1986;42():549-87.

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