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Michel Leroux

Research Profile

Anatomy

Chemicals & Drugs

Disorders

Bardet-Biedl Syndrome

Physiology

Concepts & Ideas

Molecular Sequence Data

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Prasad Phirke; Brian P Piasecki; Kim Schuske; Mathieu W Bakhoum; Jan Burghoorn; Filip Crona; Evgeni Efimenko; Erik M Jorgensen; Michel R Leroux; Swetha Mohan; Maria Trieb; Peter Swoboda
Transcriptional profiling of C. elegans DAF-19 uncovers a ciliary base-associated protein and a CDK/CCRK/LF2p-related kinase required for intraflagellar transport.
Corey L Williams; Chunmei Li; Katarzyna Kida; Peter N Inglis; Swetha Mohan; Lucie Semenec; Nathan J Bialas; Rachel M Stupay; Nansheng Chen; Oliver E Blacque; Bradley K Yoder; Michel R Leroux
MKS and NPHP modules cooperate to establish basal body/transition zone membrane associations and ciliary gate function during ciliogenesis.
Michel R Leroux
Tubulin acetyltransferase discovered: ciliary role in the ancestral eukaryote expanded to neurons in metazoans.

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All Publications

2011: Prasad Phirke; Brian P Piasecki; Kim Schuske; Mathieu W Bakhoum; Jan Burghoorn; Filip Crona; Evgeni Efimenko; Erik M Jorgensen; Michel R Leroux; Swetha Mohan; Maria Trieb; Peter Swoboda
Transcriptional profiling of C. elegans DAF-19 uncovers a ciliary base-associated protein and a CDK/CCRK/LF2p-related kinase required for intraflagellar transport.
Developmental biology 2011;357(1):235-47.
2011: Corey L Williams; Chunmei Li; Katarzyna Kida; Peter N Inglis; Swetha Mohan; Lucie Semenec; Nathan J Bialas; Rachel M Stupay; Nansheng Chen; Oliver E Blacque; Bradley K Yoder; Michel R Leroux
MKS and NPHP modules cooperate to establish basal body/transition zone membrane associations and ciliary gate function during ciliogenesis.
The Journal of cell biology 2011;192(6):1023-41.
2010: Michel R Leroux
Tubulin acetyltransferase discovered: ciliary role in the ancestral eukaryote expanded to neurons in metazoans.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(50):21238-9.
2010: Victor L Jensen; Nathan J Bialas; Sharon L Bishop-Hurley; Laurie L Molday; Katarzyna Kida; Phuong Anh T Nguyen; Oliver E Blacque; Robert S Molday; Michel R Leroux; Donald L Riddle
Localization of a guanylyl cyclase to chemosensory cilia requires the novel ciliary MYND domain protein DAF-25.
PLoS genetics 2010;6(11):e1001199.
2010: Jacque-Lynne F Johnson; Michel R Leroux
cAMP and cGMP signaling: sensory systems with prokaryotic roots adopted by eukaryotic cilia.
Trends in cell biology 2010;20(8):435-44.
2010: Cheryl J Wiens; Yufeng Tong; Muneer A Esmail; Edwin Oh; Jantje M Gerdes; Jihong Wang; Wolfram Tempel; Jerome B Rattner; Nicholas Katsanis; Hee-Won Park; Michel R Leroux
Bardet-Biedl syndrome-associated small GTPase ARL6 (BBS3) functions at or near the ciliary gate and modulates Wnt signaling.
The Journal of biological chemistry 2010;285(21):16218-30.
2010: Victor F Lundin; Michel R Leroux; Peter C Stirling
Quality control of cytoskeletal proteins and human disease.
Trends in biochemical sciences 2010;35(5):288-97.
2010: Lynne M Quarmby; Michel R Leroux
Sensorium: the original raison d'etre of the motile cilium?
Journal of molecular cell biology 2010;2(2):65-7.
2009: Michael A Silverman; Michel R Leroux
Intraflagellar transport and the generation of dynamic, structurally and functionally diverse cilia.
Trends in cell biology 2009;19(7):306-16.
2009: Nathan J Bialas; Peter N Inglis; Chunmei Li; Jon F Robinson; Jeremy D K Parker; Michael P Healey; Erica E Davis; Chrystal D Inglis; Tiina Toivonen; David C Cottell; Oliver E Blacque; Lynne M Quarmby; Nicholas Katsanis; Michel R Leroux
Functional interactions between the ciliopathy-associated Meckel syndrome 1 (MKS1) protein and two novel MKS1-related (MKSR) proteins.
Journal of cell science 2009;122(Pt 5):611-24.
2008: Chunmei Li; Peter N Inglis; Carmen C Leitch; Evgeni Efimenko; Norann Zaghloul; Calvin A Mok; Erica E Davis; Nathan J Bialas; Michael P Healey; Elise Héon; Mei Zhen; Peter Swoboda; Nicholas Katsanis; Michel R Leroux
An essential role for DYF-11/MIP-T3 in assembling functional intraflagellar transport complexes.
PLoS genetics 2008;4(3):e1000044.
2008: Victor F Lundin; Martin Srayko; Anthony A Hyman; Michel R Leroux
Efficient chaperone-mediated tubulin biogenesis is essential for cell division and cell migration in C. elegans.
Developmental biology 2008;313(1):320-34.
2007: Perciliz L Tan; Travis Barr; Peter N Inglis; Norimasa Mitsuma; Susan M Huang; Miguel A Garcia-Gonzalez; Brian A Bradley; Stephanie Coforio; Phillip J Albrecht; Terry Watnick; Gregory G Germino; Philip L Beales; Michael J Caterina; Michel R Leroux; Frank rice; Nicholas Katsanis
Loss of Bardet Biedl syndrome proteins causes defects in peripheral sensory innervation and function.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(44):17524-9.
2007: Michel R Leroux
Taking vesicular transport to the cilium.
Cell 2007;129(6):1041-3.
2007: Peter C Stirling; Martin Srayko; Karam S Takhar; Andrei Pozniakovsky; Anthony A Hyman; Michel R Leroux
Functional interaction between phosducin-like protein 2 and cytosolic chaperonin is essential for cytoskeletal protein function and cell cycle progression.
Molecular biology of the cell 2007;18(6):2336-45.
2007: Guangshuo Ou; Makato Koga; Oliver E Blacque; Takashi Murayama; Yasumi Ohshima; Jenny C Schafer; Chunmei Li; Bradley K Yoder; Michel R Leroux; Jonathan M Scholey
Sensory ciliogenesis in Caenorhabditis elegans: assignment of IFT components into distinct modules based on transport and phenotypic profiles.
Molecular biology of the cell 2007;18(5):1554-69.
2007: Peter N Inglis; Guangshuo Ou; Michel R Leroux; Jonathan M Scholey
The sensory cilia of Caenorhabditis elegans.
WormBook : the online review of C. elegans biology 2007;():1-22.
2007: Jaime Martín-Benito; Juan J Gómez-Reino; Peter C Stirling; Victor F Lundin; Paulino Gómez-Puertas; Jasminka Boskovic; Pablo Chacon; José J Fernández; José Berenguer; Michel R Leroux; José M Valpuesta
Divergent substrate-binding mechanisms reveal an evolutionary specialization of eukaryotic prefoldin compared to its archaeal counterpart.
Structure (London, England : 1993) 2007;15(1):101-10.
2006: Oliver E Blacque; Chunmei Li; Peter N Inglis; Muneer A Esmail; Guangshuo Ou; Allan K Mah; David Baillie; Jonathan M Scholey; Michel R Leroux
The WD repeat-containing protein IFTA-1 is required for retrograde intraflagellar transport.
Molecular biology of the cell 2006;17(12):5053-62.
2006: Evgeni Efimenko; Oliver E Blacque; Guangshuo Ou; Courtney J. Haycraft; Bradley K Yoder; Jonathan M Scholey; Michel R Leroux; Peter Swoboda
Caenorhabditis elegans DYF-2, an orthologue of human WDR19, is a component of the intraflagellar transport machinery in sensory cilia.
Molecular biology of the cell 2006;17(11):4801-11.
2006: Peter C Stirling; Samuel Bakhoum; Andrea B Feigl; Michel R Leroux
Convergent evolution of clamp-like binding sites in diverse chaperones.
Nature structural & molecular biology 2006;13(10):865-70.
2006: Xiaoyu Pan; Guangshuo Ou; Gul Civelekoglu-Scholey; Oliver E Blacque; Nicholas F Endres; Li Tao; Alex Mogilner; Michel R Leroux; Ronald D Vale; Jonathan M Scholey
Mechanism of transport of IFT particles in C. elegans cilia by the concerted action of kinesin-II and OSM-3 motors.
The Journal of cell biology 2006;174(7):1035-45.
2006: Oliver E Blacque; Michel R Leroux
Bardet-Biedl syndrome: an emerging pathomechanism of intracellular transport.
Cellular and molecular life sciences : CMLS 2006;63(18):2145-61.
2006: Peter N Inglis; Keith A Boroevich; Michel R Leroux
Piecing together a ciliome.
Trends in genetics : TIG 2006;22(9):491-500.
2006: Peter C Stirling; Jorge Cuéllar; Gabriel A Alfaro; Fatima El Khadali; Christopher T Beh; José M Valpuesta; Ronald Melki; Michel R Leroux
PhLP3 modulates CCT-mediated actin and tubulin folding via ternary complexes with substrates.
The Journal of biological chemistry 2006;281(11):7012-21.
2006: Nansheng Chen; Allan K Mah; Oliver E Blacque; Jeffrey Chu; Kiran Phgora; Mathieu Bakhoum; C Rebecca Hunt Newbury; Jaswinder Khattra; Susanna Chan; Anne Go; Evgeni Efimenko; Robert C Johnsen; Prasad Phirke; Peter Swoboda; Marco Marra; Donald G Moerman; Michel R Leroux; David Baillie; Lincoln D Stein
Identification of ciliary and ciliopathy genes in Caenorhabditis elegans through comparative genomics.
Genome biology 2006;7(12):R126.
2005: Alison J Ross; Helen May-Simera; Erica R Eichers; Masatake Kai; Josephine Hill; Daniel J Jagger; Carmen C Leitch; J Paul Chapple; Peter M G Munro; Shannon Fisher; Perciliz L Tan; Helen M Phillips; Michel R Leroux; Deborah J Henderson; Jennifer N Murdoch; Andrew J Copp; Marie-Madeleine Eliot; James R Lupski; David T Kemp; Hélène Dollfus; Masazumi Tada; Nicholas Katsanis; Andrew Forge; Philip L Beales
Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates.
Nature genetics 2005;37(10):1135-40.
2005: Guangshuo Ou; Oliver E Blacque; Joshua J Snow; Michel R Leroux; Jonathan M Scholey
Functional coordination of intraflagellar transport motors.
Nature 2005;436(7050):583-7.
2005: Oliver E Blacque; Elliot A Perens; Keith A Boroevich; Peter N Inglis; Chunmei Li; Adam Warner; Jaswinder Khattra; Rob A Holt; Guangshuo Ou; Allan K Mah; Sheldon J McKay; Peter Huang; Peter Swoboda; Steven J M Jones; Marco A Marra; David Baillie; Donald G Moerman; Shai Shaham; Michel R Leroux
Functional genomics of the cilium, a sensory organelle.
Current biology : CB 2005;15(10):935-41.
2005: Evgeni Efimenko; Kerry Bubb; Ho Yi Mak; Ted Holzman; Michel R Leroux; Gary Ruvkun; James H Thomas; Peter Swoboda
Analysis of xbx genes in C. elegans.
Development (Cambridge, England) 2005;132(8):1923-34.
2005: Jun Chul Kim; Young Y Ou; Jose L Badano; Muneer A Esmail; Carmen C Leitch; Elsa Fiedrich; Philip L Beales; John M Archibald; Nicholas Katsanis; Jerome B Rattner; Michel R Leroux
MKKS/BBS6, a divergent chaperonin-like protein linked to the obesity disorder Bardet-Biedl syndrome, is a novel centrosomal component required for cytokinesis.
Journal of cell science 2005;118(Pt 5):1007-20.
2004: Yanli Fan; Muneer A Esmail; Stephen J Ansley; Oliver E Blacque; Keith A Boroevich; Alison J Ross; Susan J Moore; Jose L Badano; Helen May-Simera; Deanna S Compton; Jane S Green; Richard Alan Lewis; Mieke M van Haelst; Patrick S Parfrey; David Baillie; Philip L Beales; Nicholas Katsanis; William S Davidson; Michel R Leroux
Mutations in a member of the Ras superfamily of small GTP-binding proteins causes Bardet-Biedl syndrome.
Nature genetics 2004;36(9):989-93.
2004: Oliver E Blacque; Michael J Reardon; Chunmei Li; Jonathan McCarthy; Moe R Mahjoub; Stephen J Ansley; Jose L Badano; Allan K Mah; Philip L Beales; William S Davidson; Robert C Johnsen; Mark Audeh; Ronald H Plasterk; David Baillie; Nicholas Katsanis; Lynne M Quarmby; Stephen R Wicks; Michel R Leroux
Loss of C. elegans BBS-7 and BBS-8 protein function results in cilia defects and compromised intraflagellar transport.
Genes & development 2004;18(13):1630-42.
2004: Jin Billy Li; Jantje M Gerdes; Courtney J. Haycraft; Yanli Fan; Tanya M Teslovich; Helen May-Simera; Haitao Li; Oliver E Blacque; Linya Li; Carmen C Leitch; Richard Allan Lewis; Jane S Green; Patrick S Parfrey; Michel R Leroux; William S Davidson; Philip L Beales; Lisa M Guay-Woodford; Bradley K Yoder; Gary stormo; Nicholas Katsanis; Susan Dutcher
Comparative genomics identifies a flagellar and basal body proteome that includes the BBS5 human disease gene.
Cell 2004;117(4):541-52.
2004: Jun Chul Kim; Jose L Badano; Sonja Sibold; Muneer A Esmail; Josephine Hill; Bethan E Hoskins; Carmen C Leitch; Kerrie Venner; Stephen J Ansley; Alison J Ross; Michel R Leroux; Nicholas Katsanis; Philip L Beales
The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progression.
Nature genetics 2004;36(5):462-70.
2004: Victor F Lundin; Peter C Stirling; Juan J Gomez Reino; Jill C Mwenifumbo; Jennifer M Obst; José M Valpuesta; Michel R Leroux
Molecular clamp mechanism of substrate binding by hydrophobic coiled-coil residues of the archaeal chaperone prefoldin.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(13):4367-72.
2003: Stephen J Ansley; Jose L Badano; Oliver E Blacque; Josephine Hill; Bethan E Hoskins; Carmen C Leitch; Jun Chul Kim; Alison J Ross; Erica R Eichers; Tanya M Teslovich; Allan K Mah; Robert C Johnsen; John C Cavender; Richard Alan Lewis; Michel R Leroux; Philip L Beales; Nicholas Katsanis
Basal body dysfunction is a likely cause of pleiotropic Bardet-Biedl syndrome.
Nature 2003;425(6958):628-33.
2003: Jose L Badano; Jun Chul Kim; Bethan E Hoskins; Richard Alan Lewis; Stephen J Ansley; David J Cutler; Claudio Castellan; Philip L Beales; Michel R Leroux; Nicholas Katsanis
Heterozygous mutations in BBS1, BBS2 and BBS6 have a potential epistatic effect on Bardet-Biedl patients with two mutations at a second BBS locus.
Human molecular genetics 2003;12(14):1651-9.
2003: Peter C Stirling; Victor F Lundin; Michel R Leroux
Getting a grip on non-native proteins.
EMBO reports 2003;4(6):565-70.
2001: Michel R Leroux
Protein folding and molecular chaperones in archaea.
Advances in applied microbiology 2001;50():219-77.
1997: Michel R Leroux; E Peter M Candido
Subunit characterization of the Caenorhabditis elegans chaperonin containing TCP-1 and expression pattern of the gene encoding CCT-1.
Biochemical and biophysical research communications 1997;241(3):687-92.
1997: Michel R Leroux; Ronald Melki; B Gordon; G Batelier; E Peter M Candido
Structure-function studies on small heat shock protein oligomeric assembly and interaction with unfolded polypeptides.
The Journal of biological chemistry 1997;272(39):24646-56.
1997: Michel R Leroux; B J Ma; G Batelier; Ronald Melki; E Peter M Candido
Unique structural features of a novel class of small heat shock proteins.
The Journal of biological chemistry 1997;272(19):12847-53.