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Gene Lesage
This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers
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Research Profile (preview)
Living Beings
Anatomy
Chemicals & Drugs
Physiology
Devices
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Network (preview)
42
Alpini, Gianfranco
29
Phinizy, Jo Lynne
28
Glaser, Shannon
27
Francis, Heather
17
Marzioni, Marco
17
Ueno, Yoshiyuki
16
Alvaro, Domenico
12
Baiocchi, Leonardo
12
Glaser, Shannon
12
Marucci, Luca
10
Benedetti, Antonio
9
Caligiuri, Alessandra
8
Kanno, Noriatsu
6
Lasater, J
6
Venter, Julie
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Publications
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Geonetwork of Gene Lesage (preview)
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All Publications
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2009: Reisenauer Mary Rose; Anderson Marc; Huang Le; Zhang Zhijing; Zhou Qiaoling; Kone Bruce C; Morris Andrew P; Lesage Gene D; Dryer Stuart E; Zhang Wenzheng
AF17 competes with AF9 for binding to Dot1a to up-regulate transcription of epithelial Na+ channel alpha.
The Journal of biological chemistry 2009;284(51):35659-69.
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2007: Xia Xuefeng; Demorrow Sharon; Francis Heather; Glaser Shannon; Alpini Gianfranco; Marzioni Marco; Fava Giammarco; Lesage Gene
Cholangiocyte injury and ductopenic syndromes.
Seminars in liver disease 2007;27(4):401-12.
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2007: Francis Heather; LeSage Gene; DeMorrow Sharon; Alvaro Domenico; Ueno Yoshiyuki; Venter Julie; Glaser Shannon; Mancino Maria Grazia; Marucci Luca; Benedetti Antonio; Alpini Gianfranco
The alpha2-adrenergic receptor agonist UK 14,304 inhibits secretin-stimulated ductal secretion by downregulation of the cAMP system in bile duct-ligated rats.
American journal of physiology. Cell physiology 2007;293(4):C1252-62.
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2006: Glaser Shannon; Francis Heather; Demorrow Sharon; Lesage Gene; Fava Giammarco; Marzioni Marco; Venter Julie; Alpini Gianfranco
Heterogeneity of the intrahepatic biliary epithelium.
World journal of gastroenterology : WJG 2006;12(22):3523-36.
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2006: Zhang Wenzheng; Xia Xuefeng; Jalal Diana I; Kuncewicz Teresa; Xu William; Lesage Gene D; Kone Bruce C
Aldosterone-sensitive repression of ENaCalpha transcription by a histone H3 lysine-79 methyltransferase.
American journal of physiology. Cell physiology 2006;290(3):C936-46.
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2005: Alpini Gianfranco; Glaser Shannon; Baiocchi Leonardo; Francis Heather; Xia Xuefeng; Lesage Gene
Secretin activation of the apical Na+-dependent bile acid transporter is associated with cholehepatic shunting in rats.
Hepatology (Baltimore, Md.) 2005;41(5):1037-45.
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2005: Marzioni Marco; Glaser Shannon; Francis Heather; Marucci Luca; Benedetti Antonio; Alvaro Domenico; Taffetani Silvia; Ueno Yoshiyuki; Roskams Tania; Phinizy Jo Lynne; Venter Juliet; Fava Giammarco; Lesage Gene D; Alpini Gianfranco
Autocrine/paracrine regulation of the growth of the biliary tree by the neuroendocrine hormone serotonin.
Gastroenterology 2005;128(1):121-37.
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2004: LeSage Gene D; Alvaro Domenico; Glaser Shannon; Francis Heather; Marucci Luca; Roskams Tania; Phinizy Jo Lynne; Marzioni Marco; Benedetti Antonio; Taffetani Silvia; Barbaro Barbara; Fava Giammarco; Ueno Yoshiyuki; Alpini Gianfranco
Alpha-1 adrenergic receptor agonists modulate ductal secretion of BDL rats via Ca(2+)- and PKC-dependent stimulation of cAMP.
Hepatology (Baltimore, Md.) 2004;40(5):1116-27.
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2004: Francis Heather; Glaser Shannon; Ueno Yoshiyuki; Lesage Gene; Marucci Luca; Benedetti Antonio; Taffetani Silvia; Marzioni Marco; Alvaro Domenico; Venter Julie; Reichenbach Ramona; Fava Giammarco; Phinizy Jo Lynne; Alpini Gianfranco
cAMP stimulates the secretory and proliferative capacity of the rat intrahepatic biliary epithelium through changes in the PKA/Src/MEK/ERK1/2 pathway.
Journal of hepatology 2004;41(4):528-37.
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2004: Xia Xuefeng; Roundtree Marlon; Merikhi Afkhamossadat; Lu Xiaohui; Shentu Shujun; Lesage Gene
Degradation of the apical sodium-dependent bile acid transporter by the ubiquitin-proteasome pathway in cholangiocytes.
The Journal of biological chemistry 2004;279(43):44931-7.
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2004: Zhang Wenzheng; Xia Xuefeng; Zou Lei; Xu Xiangyang; LeSage Gene D; Kone Bruce C
In vivo expression profile of a H+-K+-ATPase alpha2-subunit promoter-reporter transgene.
American journal of physiology. Renal physiology 2004;286(6):F1171-7.
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2004: Alpini Gianfranco; Kanno Noriatsu; Phinizy Jo Lynne; Glaser Shannon; Francis Heather; Taffetani Silvia; LeSage Gene
Tauroursodeoxycholate inhibits human cholangiocarcinoma growth via Ca2+-, PKC-, and MAPK-dependent pathways.
American journal of physiology. Gastrointestinal and liver physiology 2004;286(6):G973-82.
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2003: Ueno Yoshiyuki; Alpini Gianfranco; Yahagi Kaichiro; Kanno Noriatsu; Moritoki Yuki; Fukushima Koji; Glaser Shannon; LeSage Gene; Shimosegawa Tooru
Evaluation of differential gene expression by microarray analysis in small and large cholangiocytes isolated from normal mice.
Liver international : official journal of the International Association for the Study of the Liver 2003;23(6):449-59.
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2003: Alpini Gianfranco; Ueno Yoshiyuki; Tadlock Laura; Glaser Shannon S; LeSage Gene; Francis Heather; Taffetani Silvia; Marzioni Marco; Alvaro Domenico; Patel Tushar
Increased susceptibility of cholangiocytes to tumor necrosis factor-alpha cytotoxicity after bile duct ligation.
American journal of physiology. Cell physiology 2003;285(1):C183-94.
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2003: Alpini Gianfranco; Phinizy Jo Lynne; Glaser Shannon; Francis Heather; Benedetti Antonio; Marucci Luca; LeSage Gene
Development and characterization of secretin-stimulated secretion of cultured rat cholangiocytes.
American journal of physiology. Gastrointestinal and liver physiology 2003;284(6):G1066-73.
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2003: Marzioni Marco; LeSage Gene D; Glaser Shannon; Patel Tushar; Marienfeld Carla; Ueno Yoshiyuki; Francis Heather; Alvaro Domenico; Tadlock Laura; Benedetti Antonio; Marucci Luca; Baiocchi Leonardo; Phinizy Jo Lynne; Alpini Gianfranco
Taurocholate prevents the loss of intrahepatic bile ducts due to vagotomy in bile duct-ligated rats.
American journal of physiology. Gastrointestinal and liver physiology 2003;284(5):G837-52.
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2003: Glaser Sharon; Alvaro Domenico; Ueno Yoshiyuki; Francis Heather; Marzioni Marco; Phinizy Jo Lynne; Baumann Brandy; Mancino Maria Grazia; Venter Julie; LeSage Gene; Alpini Gianfranco
Gastrin reverses established cholangiocyte proliferation and enhanced secretin-stimulated ductal secretion of BDL rats by activation of apoptosis through increased expression of Ca2+- dependent PKC isoforms.
Liver international : official journal of the International Association for the Study of the Liver 2003;23(2):78-88.
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2003: Glaser Shannon; Alvaro Domenico; Roskams Tania; Phinizy Jo Lynne; Stoica George; Francis Heather; Ueno Yoshiyuki; Barbaro Barbara; Marzioni Marco; Mauldin Jeremy; Rashid Sobia; Mancino Maria Grazia; LeSage Gene; Alpini Gianfranco
Dopaminergic inhibition of secretin-stimulated choleresis by increased PKC-gamma expression and decrease of PKA activity.
American journal of physiology. Gastrointestinal and liver physiology 2003;284(4):G683-94.
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2003: Baiocchi Leonardo; Alpini Gianfranco; Glaser Shannon; Angelico Mario; Alvaro Domenico; Francis Heather; Marzioni Marco; Phinizy Jo Lynne; Barbaro Barbara; LeSage Gene
Taurohyodeoxycholate- and tauroursodeoxycholate-induced hypercholeresis is augmented in bile duct ligated rats.
Journal of hepatology 2003;38(2):136-47.
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2003: Marucci Luca; Alpini Gianfranco; Glaser Shannon S; Alvaro Domenico; Benedetti Antonio; Francis Heather; Phinizy Jo Lynne; Marzioni Marco; Mauldin Jeremy; Venter Julie; Baumann Brandy; Ugili Laura; LeSage Gene
Taurocholate feeding prevents CCl4-induced damage of large cholangiocytes through PI3-kinase-dependent mechanism.
American journal of physiology. Gastrointestinal and liver physiology 2003;284(2):G290-301.
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2002: Alpini Gianfranco; Glaser Shannon; Alvaro Domenico; Ueno Yoshiyuki; Marzioni Marco; Francis Heather; Baiocchi Leonardo; Stati Tonino; Barbaro Barbara; Phinizy Jo Lynne; Mauldin Jeremy; Lesage Gene
Bile acid depletion and repletion regulate cholangiocyte growth and secretion by a phosphatidylinositol 3-kinase-dependent pathway in rats.
Gastroenterology 2002;123(4):1226-37.
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2002: Lesage Gene D; Marucci Luca; Alvaro Domenico; Glaser Shannon S; Benedetti Antonio; Marzioni Marco; Patel Tushar; Francis Heather; Phinizy Jo Lynne; Alpini Gianfranco
Insulin inhibits secretin-induced ductal secretion by activation of PKC alpha and inhibition of PKA activity.
Hepatology (Baltimore, Md.) 2002;36(3):641-51.
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2002: Marzioni Marco; Glaser Shannon S; Francis Heather; Phinizy Jo Lynne; LeSage Gene; Alpini Gianfranco
Functional heterogeneity of cholangiocytes.
Seminars in liver disease 2002;22(3):227-40.
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2002: Kanno Noriatsu; Lesage Gene; Phinizy Jo Lynne; Glaser Shannon; Francis Heather; Alpini Gianfranco
Stimulation of alpha2-adrenergic receptor inhibits cholangiocarcinoma growth through modulation of Raf-1 and B-Raf activities.
Hepatology (Baltimore, Md.) 2002;35(6):1329-40.
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2002: Alpini Gianfranco; Baiocchi Leonardo; Glaser Shannon; Ueno Yoshiyuki; Marzioni Marco; Francis Heather; Phinizy Jo Lynne; Angelico Mario; Lesage Gene
Ursodeoxycholate and tauroursodeoxycholate inhibit cholangiocyte growth and secretion of BDL rats through activation of PKC alpha.
Hepatology (Baltimore, Md.) 2002;35(5):1041-52.
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2001: Alpini G; Ueno Y; Glaser S S; Marzioni M; Phinizy J L; Francis H; Lesage G
Bile acid feeding increased proliferative activity and apical bile acid transporter expression in both small and large rat cholangiocytes.
Hepatology (Baltimore, Md.) 2001;34(5):868-76.
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2001: Marzioni M; Glaser S S; Alpini G; LeSage G D
Role of apoptosis in development of primary biliary cirrhosis.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2001;33(7):531-3.
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2001: Kanno N; LeSage G; Glaser S; Alpini G
Regulation of cholangiocyte bicarbonate secretion.
American journal of physiology. Gastrointestinal and liver physiology 2001;281(3):G612-25.
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2001: Lesage G; Glaser S; Ueno Y; Alvaro D; Baiocchi L; Kanno N; Phinizy J L; Francis H; Alpini G
Regression of cholangiocyte proliferation after cessation of ANIT feeding is coupled with increased apoptosis.
American journal of physiology. Gastrointestinal and liver physiology 2001;281(1):G182-90.
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2001: Kanno N; Glaser S; Chowdhury U; Phinizy J L; Baiocchi L; Francis H; LeSage G; Alpini G
Gastrin inhibits cholangiocarcinoma growth through increased apoptosis by activation of Ca2+-dependent protein kinase C-alpha.
Journal of hepatology 2001;34(2):284-91.
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2000: LeSage G; Glaser S; Alpini G
Regulatory mechanisms of ductal bile secretion.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2000;32(7):563-6.
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2000: Glaser S; Benedetti A; Marucci L; Alvaro D; Baiocchi L; Kanno N; Caligiuri A; Phinizy J L; Chowdury U; Papa E; LeSage G; Alpini G
Gastrin inhibits cholangiocyte growth in bile duct-ligated rats by interaction with cholecystokinin-B/Gastrin receptors via D-myo-inositol 1,4,5-triphosphate-, Ca(2+)-, and protein kinase C alpha-dependent mechanisms.
Hepatology (Baltimore, Md.) 2000;32(1):17-25.
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2000: Kanno N; LeSage G; Glaser S; Alvaro D; Alpini G
Functional heterogeneity of the intrahepatic biliary epithelium.
Hepatology (Baltimore, Md.) 2000;31(3):555-61.
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1999: Baiocchi L; LeSage G; Glaser S; Alpini G
Regulation of cholangiocyte bile secretion.
Journal of hepatology 1999;31(1):179-91.
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1999: LeSagE G; Alvaro D; Benedetti A; Glaser S; Marucci L; Baiocchi L; Eisel W; Caligiuri A; Phinizy J L; Rodgers R; Francis H; Alpini G
Cholinergic system modulates growth, apoptosis, and secretion of cholangiocytes from bile duct-ligated rats.
Gastroenterology 1999;117(1):191-9.
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1999: LeSage G D; Glaser S S; Marucci L; Benedetti A; Phinizy J L; Rodgers R; Caligiuri A; Papa E; Tretjak Z; Jezequel A M; Holcomb L A; Alpini G
Acute carbon tetrachloride feeding induces damage of large but not small cholangiocytes from BDL rat liver.
The American journal of physiology 1999;276(5 Pt 1):G1289-301.
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1999: LeSage G D; Benedetti A; Glaser S; Marucci L; Tretjak Z; Caligiuri A; Rodgers R; Phinizy J L; Baiocchi L; Francis H; Lasater J; Ugili L; Alpini G
Acute carbon tetrachloride feeding selectively damages large, but not small, cholangiocytes from normal rat liver.
Hepatology (Baltimore, Md.) 1999;29(2):307-19.
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1999: Alpini G; Glaser S S; Ueno Y; Rodgers R; Phinizy J L; Francis H; Baiocchi L; Holcomb L A; Caligiuri A; LeSage G D
Bile acid feeding induces cholangiocyte proliferation and secretion: evidence for bile acid-regulated ductal secretion.
Gastroenterology 1999;116(1):179-86.
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1998: Alpini G; Glaser S S; Ueno Y; Pham L; Podila P V; Caligiuri A; LeSage G; LaRusso N F
Heterogeneity of the proliferative capacity of rat cholangiocytes after bile duct ligation.
The American journal of physiology 1998;274(4 Pt 1):G767-75.
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1997: Glaser S S; Rodgers R E; Phinizy J L; Robertson W E; Lasater J; Caligiuri A; Tretjak Z; LeSage G D; Alpini G
Gastrin inhibits secretin-induced ductal secretion by interaction with specific receptors on rat cholangiocytes.
The American journal of physiology 1997;273(5 Pt 1):G1061-70.
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1997: Alpini G; Glaser S S; Rodgers R; Phinizy J L; Robertson W E; Lasater J; Caligiuri A; Tretjak Z; LeSage G D
Functional expression of the apical Na+-dependent bile acid transporter in large but not small rat cholangiocytes.
Gastroenterology 1997;113(5):1734-40.
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1997: Alpini G; Elias I; Glaser S S; Rodgers R E; Phinizy J L; Robertson W E; Francis H; Lasater J; Richards M; LeSage G D
gamma-Interferon inhibits secretin-induced choleresis and cholangiocyte proliferation in a murine model of cirrhosis.
Journal of hepatology 1997;27(2):371-80.
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1997: Alpini G; Glaser S; Robertson W; Phinizy J L; Rodgers R E; Caligiuri A; LeSage G
Bile acids stimulate proliferative and secretory events in large but not small cholangiocytes.
The American journal of physiology 1997;273(2 Pt 1):G518-29.
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1997: Alpini G; Glaser S; Robertson W; Rodgers R E; Phinizy J L; Lasater J; LeSage G D
Large but not small intrahepatic bile ducts are involved in secretin-regulated ductal bile secretion.
The American journal of physiology 1997;272(5 Pt 1):G1064-74.
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1997: Alpini G; Ulrich C; Roberts S; Phillips J O; Ueno Y; Podila P V; Colegio O; LeSage G D; Miller L J; LaRusso N F
Molecular and functional heterogeneity of cholangiocytes from rat liver after bile duct ligation.
The American journal of physiology 1997;272(2 Pt 1):G289-97.
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1996: Lesage G; Glaser S S; Gubba S; Robertson W E; Phinizy J L; Lasater J; Rodgers R E; Alpini G
Regrowth of the rat biliary tree after 70% partial hepatectomy is coupled to increased secretin-induced ductal secretion.
Gastroenterology 1996;111(6):1633-44.
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1996: Alpini G; Roberts S; Kuntz S M; Ueno Y; Gubba S; Podila P V; LeSage G; LaRusso N F
Morphological, molecular, and functional heterogeneity of cholangiocytes from normal rat liver.
Gastroenterology 1996;110(5):1636-43.
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1993: LeSage G D; Robertson W E; Baumgart M A
Bile acid-dependent vesicular transport of lysosomal enzymes into bile in the rat.
Gastroenterology 1993;105(3):889-900.
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1990: LeSage G D; Robertson W E; Baumgart M A
Demonstration of vesicular-dependent bile flow in the sucrose-loaded rat.
Gastroenterology 1990;99(2):478-87.
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