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Arthur Lesk

Research Profile

Concepts & Ideas

Genes & Molecular Sequences

Amino Acid Sequences

Chemicals & Drugs

Phenomena

Physiology

Protein Folding

Procedures

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Computational Biology

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Publications

TOP 3
Arthur M Lesk
Comment on "Comparing proteins by their internal dynamics: exploring structure-function relationships beyond static structural alignments" by C. Micheletti.
Arun S Konagurthu; Arthur M Lesk
Structure description and identification using the tableau representation of protein folding patterns.
James H Collier; Maria Garcia de la Banda; Arthur M Lesk; Arun S Konagurthu
Super: a web server to rapidly screen superposable oligopeptide fragments from the protein data bank.

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All Publications

2013: Arthur M Lesk
Comment on "Comparing proteins by their internal dynamics: exploring structure-function relationships beyond static structural alignments" by C. Micheletti.
Physics of life reviews 2013;10(1):33-4; discussion 39-40.
2013: Arun S Konagurthu; Arthur M Lesk
Structure description and identification using the tableau representation of protein folding patterns.
Methods in molecular biology (Clifton, N.J.) 2013;932():51-9.
2012: James H Collier; Maria Garcia de la Banda; Arthur M Lesk; Arun S Konagurthu
Super: a web server to rapidly screen superposable oligopeptide fragments from the protein data bank.
Nucleic acids research 2012;40(Web Server issue):W334-9.
2012: Arun S Konagurthu; Arthur M Lesk; Lloyd Allison
Minimum message length inference of secondary structure from protein coordinate data.
Bioinformatics (Oxford, England) 2012;28(12):i97-105.
2011: Webb Miller; Nick Patterson; Desiree C Petersen; Thomas H Pringle; Stephen Pyecroft; Ji Qi; Aakrosh Ratan; Oscar C Bedoya-Reina; Mads Frost Bertelsen; Dale Dixon; Rae-Anne Hardie; Vanessa M Hayes; Kristofer M Helgen; Menna E Jones; Lindsay McClellan Kasson; Neerja Katiyar; James Knight; Alexandre Kreiss; Arthur M Lesk; Jason Miller; Elizabeth A Tindall; Lynn P Tomsho; Brian Walenz; Qingyu Wang; Nicola E Wittekindt; Paula Woodbridge; Gregory M Woods; Yu Zhang; Fangqing Zhao; Stephan C Schuster
Genetic diversity and population structure of the endangered marsupial Sarcophilus harrisii (Tasmanian devil).
Proceedings of the National Academy of Sciences of the United States of America 2011;108(30):12348-53.
2011: Arun S Konagurthu; Lloyd Allison; Peter J Stuckey; Arthur M Lesk
Piecewise linear approximation of protein structures using the principle of minimum message length.
Bioinformatics (Oxford, England) 2011;27(13):i43-51.
2010: Arun S Konagurthu; Arthur M Lesk
Cataloging topologies of protein folding patterns.
Journal of molecular recognition : JMR 2010;23(2):253-7.
2010: Arun S Konagurthu; Cyril F Reboul; Jason W Schmidberger; James A Irving; Arthur M Lesk; Peter J Stuckey; James C Whisstock; Ashley M Buckle
MUSTANG-MR structural sieving server: applications in protein structural analysis and crystallography.
PloS one 2010;5(4):e10048.
2009: Webb Miller; Daniela I Drautz; Jan E Janecka; Arthur M Lesk; Aakrosh Ratan; Lynn P Tomsho; Mike Packard; Yeting Zhang; Lindsay R McClellan; Ji Qi; Fangqing Zhao; M Thomas P Gilbert; Love Dalén; Juan Luis Arsuaga; Per G P Ericson; Daniel H Huson; Kristofer M Helgen; William J Murphy; Anders Gotherstrom; Stephan C Schuster
The mitochondrial genome sequence of the Tasmanian tiger (Thylacinus cynocephalus).
Genome research 2009;19(2):213-20.
2008: Webb Miller; Daniela I Drautz; Aakrosh Ratan; Barbara Pusey; Ji Qi; Arthur M Lesk; Lynn P Tomsho; Michael D Packard; Fangqing Zhao; Andrei Sher; Alexei Tikhonov; Brian J Raney; Nick Patterson; Kerstin Lindblad-Toh; Eric S Lander; James R Knight; Gerard P Irzyk; Karin M Fredrikson; Timothy T Harkins; Sharon Sheridan; Tom Pringle; Stephan C Schuster
Sequencing the nuclear genome of the extinct woolly mammoth.
Nature 2008;456(7220):387-90.
2008: Arun S Konagurthu; Arthur M Lesk
Single and multiple input modules in regulatory networks.
Proteins 2008;73(2):320-4.
2008: Vineet Sangar; Victor I Lesk; Arthur M Lesk
On the use of overlapping lattices for screening to find pairs of nearby points in two and three dimensions.
Computational biology and chemistry 2008;32(3):212-4.
2008: Andrea Zen; Vincenzo Carnevale; Arthur M Lesk; Cristian Micheletti
Correspondences between low-energy modes in enzymes: dynamics-based alignment of enzymatic functional families.
Protein science : a publication of the Protein Society 2008;17(5):918-29.
2008: Arun S Konagurthu; Peter J Stuckey; Arthur M Lesk
Structural search and retrieval using a tableau representation of protein folding patterns.
Bioinformatics (Oxford, England) 2008;24(5):645-51.
2008: Arun S Konagurthu; Arthur M Lesk
On the origin of distribution patterns of motifs in biological networks.
BMC systems biology 2008;2():73.
2007: Akhil P Kamat; Arthur M Lesk
Contact patterns between helices and strands of sheet define protein folding patterns.
Proteins 2007;66(4):869-76.
2007: Vineet Sangar; Daniel J Blankenberg; Naomi Altman; Arthur M Lesk
Quantitative sequence-function relationships in proteins based on gene ontology.
BMC bioinformatics 2007;8():294.
2006: Arun S Konagurthu; James C Whisstock; Peter J Stuckey; Arthur M Lesk
MUSTANG: a multiple structural alignment algorithm.
Proteins 2006;64(3):559-74.
2006: Timothy R Lezon; Jayanth R Banavar; Arthur M Lesk; Amos Maritan
What determines the spectrum of protein native state structures?
Proteins 2006;63(2):273-7.
2006: David Zanuy; Kannan Gunasekaran; Arthur M Lesk; Ruth Nussinov
Computational study of the fibril organization of polyglutamine repeats reveals a common motif identified in beta-helices.
Journal of molecular biology 2006;358(1):330-45.
2005: Melik C Demirel; Arthur M Lesk
Molecular forces in antibody maturation.
Physical review letters 2005;95(20):208106.
2005: Juliette T J Lecomte; David A Vuletich; Arthur M Lesk
Structural divergence and distant relationships in proteins: evolution of the globins.
Current opinion in structural biology 2005;15(3):290-301.
2005: Noel G Faux; Stephen P Bottomley; Arthur M Lesk; James Irving; John R Morrison; Maria Garcia de la Banda; James C Whisstock
Functional insights from the distribution and role of homopeptide repeat-containing proteins.
Genome research 2005;15(4):537-51.
2005: Kate F Fulton; Ashley M Buckle; Lisa D Cabrita; James Irving; Rebecca E Butcher; Ian Smith; Shane Reeve; Arthur M Lesk; Stephen P Bottomley; Jamie Rossjohn; James C Whisstock
The high resolution crystal structure of a native thermostable serpin reveals the complex mechanism underpinning the stressed to relaxed transition.
The Journal of biological chemistry 2005;280(9):8435-42.
2003: Arthur M Lesk
Hydrophobicity--getting into hot water.
Biophysical chemistry 2003;105(2-3):179-82.
2003: James C Whisstock; Arthur M Lesk
Prediction of protein function from protein sequence and structure.
Quarterly reviews of biophysics 2003;36(3):307-40.
2002: James Irving; Peter J M Steenbakkers; Arthur M Lesk; Huub J M Op den Camp; Robert N Pike; James C Whisstock
Serpins in prokaryotes.
Molecular biology and evolution 2002;19(11):1881-90.
2002: Dawn J Brooks; Jacques R Fresco; Arthur M Lesk; Mona Singh
Evolution of amino acid frequencies in proteins over deep time: inferred order of introduction of amino acids into the genetic code.
Molecular biology and evolution 2002;19(10):1645-55.
2002: MF Perutz; J T Finch; John Berriman; Arthur M Lesk
Amyloid fibers are water-filled nanotubes.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(8):5591-5.
2001: James Irving; James C Whisstock; Arthur M Lesk
Protein structural alignments and functional genomics.
Proteins 2001;42(3):378-82.
2001: Arthur M Lesk; Loredana Lo Conte; Tim Hubbard
Assessment of novel fold targets in CASP4: predictions of three-dimensional structures, secondary structures, and interresidue contacts.
Proteins 2001;Suppl 5():98-118.
2000: James Irving; Robert N Pike; Arthur M Lesk; James C Whisstock
Phylogeny of the serpin superfamily: implications of patterns of amino acid conservation for structure and function.
Genome research 2000;10(12):1845-64.
2000: James C Whisstock; Robert N Pike; L Jin; Richard Skinner; Xue Yuan Pei; Robin W Carrell; Arthur M Lesk
Conformational changes in serpins: II. The mechanism of activation of antithrombin by heparindagger.
Journal of molecular biology 2000;301(5):1287-305.
2000: Veronica Morea; Arthur M Lesk; Anna Tramontano
Antibody modeling: implications for engineering and design.
Methods (San Diego, Calif.) 2000;20(3):267-79.
2000: James C Whisstock; Richard Skinner; Robin W Carrell; Arthur M Lesk
Conformational changes in serpins: I. The native and cleaved conformations of alpha(1)-antitrypsin.
Journal of molecular biology 2000;296(2):685-99.
2000: B Al-Lazikani; Arthur M Lesk; Cyrus Chothia
Canonical structures for the hypervariable regions of T cell alphabeta receptors.
Journal of molecular biology 2000;295(4):979-95.
2000: James C Whisstock; Richard Skinner; Robin W Carrell; Arthur M Lesk
Conformational changes in serpins: I. The native and cleaved conformations of alpha(1)-antitrypsin.
Journal of molecular biology 2000;295(3):651-65.
1999: MF Perutz; M Paoli; Arthur M Lesk
Fix L, a haemoglobin that acts as an oxygen sensor: signalling mechanism and structural basis of its homology with PAS domains.
Chemistry & biology 1999;6(11):R291-7.
1999: James C Whisstock; James Irving; Stephen P Bottomley; Robert N Pike; Arthur M Lesk
Serpins in the Caenorhabditis elegans genome.
Proteins 1999;36(1):31-41.
1999: James C Whisstock; Arthur M Lesk
SH3 domains in prokaryotes.
Trends in biochemical sciences 1999;24(4):132-3.
1998: Arthur M Lesk
Extraction of geometrically similar substructures: least-squares and Chebyshev fitting and the difference distance matrix.
Proteins 1998;33(3):320-8.
1998: James C Whisstock; Richard Skinner; Arthur M Lesk
An atlas of serpin conformations.
Trends in biochemical sciences 1998;23(2):63-7.
1998: Veronica Morea; Anna Tramontano; M Rustici; Cyrus Chothia; Arthur M Lesk
Conformations of the third hypervariable region in the VH domain of immunoglobulins.
Journal of molecular biology 1998;275(2):269-94.
1997: B Al-Lazikani; Arthur M Lesk; Cyrus Chothia
Standard conformations for the canonical structures of immunoglobulins.
Journal of molecular biology 1997;273(4):927-48.
1997: Mark Wardell; Wun-Shaing W Chang; D Bruce; Richard Skinner; Arthur M Lesk; Robin W Carrell
Preparative induction and characterization of L-antithrombin: a structural homologue of latent plasminogen activator inhibitor-1.
Biochemistry 1997;36(42):13133-42.
1997: Veronica Morea; Anna Tramontano; M Rustici; C Chothia; Arthur M Lesk
Antibody structure, prediction and redesign.
Biophysical chemistry 1997;68(1-3):9-16.
1997: Richard Skinner; Jan Pieter Abrahams; James C Whisstock; Arthur M Lesk; Robin W Carrell; Mark Wardell
The 2.6 A structure of antithrombin indicates a conformational change at the heparin binding site.
Journal of molecular biology 1997;266(3):601-9.
1997: Arthur M Lesk
CASP2: report on ab initio predictions.
Proteins 1997;Suppl 1():151-66.
1997: Arthur M Lesk
Extraction of well-fitting substructures: root-mean-square deviation and the difference distance matrix.
Folding & design 1997;2(3):S12-4.
1997: Wun-Shaing W Chang; James C Whisstock; Paul C R Hopkins; Arthur M Lesk; Robin W Carrell; Mark Wardell
Importance of the release of strand 1C to the polymerization mechanism of inhibitory serpins.
Protein science : a publication of the Protein Society 1997;6(1):89-98.
1996: James C Whisstock; Arthur M Lesk; Robin W Carrell
Modeling of serpin-protease complexes: antithrombin-thrombin, alpha 1-antitrypsin (358Met-->Arg)-thrombin, alpha 1-antitrypsin (358Met-->Arg)-trypsin, and antitrypsin-elastase.
Proteins 1996;26(3):288-303.
1996: Arthur M Lesk; W D Fordham
Conservation and variability in the structures of serine proteinases of the chymotrypsin family.
Journal of molecular biology 1996;258(3):501-37.
1995: Ian M Tomlinson; J P Cox; Ermanno Gherardi; Arthur M Lesk; Cyrus Chothia
The structural repertoire of the human V kappa domain.
The EMBO journal 1995;14(18):4628-38.
1994: M Gerstein; Arthur M Lesk; Cyrus Chothia
Structural mechanisms for domain movements in proteins.
Biochemistry 1994;33(22):6739-49.
1994: Alexey G Murzin; Arthur M Lesk; Cyrus Chothia
Principles determining the structure of beta-sheet barrels in proteins. II. The observed structures.
Journal of molecular biology 1994;236(5):1382-400.
1994: Alexey G Murzin; Arthur M Lesk; Cyrus Chothia
Principles determining the structure of beta-sheet barrels in proteins. I. A theoretical analysis.
Journal of molecular biology 1994;236(5):1369-81.
1993: M Gerstein; Bryan F Anderson; G E Norris; Edward N Baker; Arthur M Lesk; Cyrus Chothia
Domain closure in lactoferrin. Two hinges produce a see-saw motion between alternative close-packed interfaces.
Journal of molecular biology 1993;234(2):357-72.
1992: Cyrus Chothia; Arthur M Lesk; Ermanno Gherardi; Ian M Tomlinson; G Walter; James D Marks; M B Llewelyn; Greg Winter
Structural repertoire of the human VH segments.
Journal of molecular biology 1992;227(3):799-817.
1992: Arthur M Lesk; Ross Boswell
It's déjà vu all over again.
Current biology : CB 1992;2(9):491-3.
1992: Arthur M Lesk; Ross Boswell
Does protein structure determine amino acid sequence?
BioEssays : news and reviews in molecular, cellular and developmental biology 1992;14(6):407-10.
1992: Alexey G Murzin; Arthur M Lesk; Cyrus Chothia
beta-Trefoil fold. Patterns of structure and sequence in the Kunitz inhibitors interleukins-1 beta and 1 alpha and fibroblast growth factors.
Journal of molecular biology 1992;223(2):531-43.
1989: Cyrus Chothia; Arthur M Lesk; A Tramontano; M Levitt; S J Smith-Gill; G Air; S Sheriff; E A Padlan; David Davies; W R Tulip
Conformations of immunoglobulin hypervariable regions.
Nature 1989;342(6252):877-83.
1989: Arthur M Lesk; Ross Boswell; V I Lesk; V E Lesk; Amos Bairoch
A cross-reference table between the Protein Data Bank of macromolecular structures and the National Biomedical Research Foundation-Protein Identification Resource amino acid sequence data bank.
Protein sequences & data analysis 1989;2(4):295-308.
1989: Arthur M Lesk; C I Brändén; Cyrus Chothia
Structural principles of alpha/beta barrel proteins: the packing of the interior of the sheet.
Proteins 1989;5(2):139-48.
1988: Cyrus Chothia; Ross Boswell; Arthur M Lesk
The outline structure of the T-cell alpha beta receptor.
The EMBO journal 1988;7(12):3745-55.
1988: Arthur M Lesk; Cyrus Chothia
Elbow motion in the immunoglobulins involves a molecular ball-and-socket joint.
Nature 1988;335(6186):188-90.
1987: Cyrus Chothia; Arthur M Lesk
Canonical structures for the hypervariable regions of immunoglobulins.
Journal of molecular biology 1987;196(4):901-17.
1987: D Bashford; Cyrus Chothia; Arthur M Lesk
Determinants of a protein fold. Unique features of the globin amino acid sequences.
Journal of molecular biology 1987;196(1):199-216.