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George Leslie

Research Profile

Anatomy

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Publications

TOP 3
Gregory Q Del Prete; George J Leslie; Beth Haggarty; Andrea P O Jordan; Josephine Romano; James A Hoxie
Distinct molecular pathways to X4 tropism for a V3-truncated human immunodeficiency virus type 1 lead to differential coreceptor interactions and sensitivity to a CXCR4 antagonist.
Gregory Q Del Prete; Beth Haggarty; George J Leslie; Andrea P O Jordan; Josephine Romano; Nathaniel Wang; Jianbin Wang; Michael C Holmes; David C Montefiori; James A Hoxie
Derivation and characterization of a simian immunodeficiency virus SIVmac239 variant with tropism for CXCR4.
Katrina M Nolan; Gregory Q Del Prete; Andrea P O Jordan; Beth Haggarty; Josephine Romano; George J Leslie; James A Hoxie
Characterization of a human immunodeficiency virus type 1 V3 deletion mutation that confers resistance to CCR5 inhibitors and the ability to use aplaviroc-bound receptor.

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All Publications

2010: Gregory Q Del Prete; George J Leslie; Beth Haggarty; Andrea P O Jordan; Josephine Romano; James A Hoxie
Distinct molecular pathways to X4 tropism for a V3-truncated human immunodeficiency virus type 1 lead to differential coreceptor interactions and sensitivity to a CXCR4 antagonist.
Journal of virology 2010;84(17):8777-89.
2009: Gregory Q Del Prete; Beth Haggarty; George J Leslie; Andrea P O Jordan; Josephine Romano; Nathaniel Wang; Jianbin Wang; Michael C Holmes; David C Montefiori; James A Hoxie
Derivation and characterization of a simian immunodeficiency virus SIVmac239 variant with tropism for CXCR4.
Journal of virology 2009;83(19):9911-22.
2009: Katrina M Nolan; Gregory Q Del Prete; Andrea P O Jordan; Beth Haggarty; Josephine Romano; George J Leslie; James A Hoxie
Characterization of a human immunodeficiency virus type 1 V3 deletion mutation that confers resistance to CCR5 inhibitors and the ability to use aplaviroc-bound receptor.
Journal of virology 2009;83(8):3798-809.
2007: George Lin; Andrea Bertolotti-Ciarlet; Beth Haggarty; Josephine Romano; Katrina M Nolan; George J Leslie; Andrea P O Jordan; Chih-chin Huang; Peter D Kwong; Robert W Doms; James A Hoxie
Replication-competent variants of human immunodeficiency virus type 2 lacking the V3 loop exhibit resistance to chemokine receptor antagonists.
Journal of virology 2007;81(18):9956-66.
2007: Meg M Laakso; Fang-Hua Lee; Beth Haggarty; Caroline Agrawal; Katrina M Nolan; Mark J Biscone; Josephine Romano; Andrea P O Jordan; George J Leslie; Eric G Meissner; Lishan Su; James A Hoxie; Robert W Doms
V3 loop truncations in HIV-1 envelope impart resistance to coreceptor inhibitors and enhanced sensitivity to neutralizing antibodies.
PLoS pathogens 2007;3(8):e117.
2007: Stefan Pöhlmann; Jan Münch; Sheriff Aziz; Jacqueline D Reeves; Claas Otto; George J Leslie; Heike Hofmann; Bridget A Puffer; Frédéric Baribaud; Andrea Marzi; Thomas Gramberg; Zhiwei Chen; Nicole Stolte; Peter Ten Haaft; Jonathan Luke Heeney; Christiane Stahl-Hennig; Kerstin Mätz-Rensing; Thomas Schneider; Robert W Doms; Frank Kirchhoff
A simian immunodeficiency virus V3 loop mutant that does not efficiently use CCR5 or common alternative coreceptors is moderately attenuated in vivo.
Virology 2007;360(2):275-85.
2004: Stefan Pöhlmann; Carl Davis; Silke Meister; George J Leslie; Claas Otto; Jacqueline D Reeves; Bridget A Puffer; Armin Papkalla; Mandy Krumbiegel; Andrea Marzi; Steffen Lorenz; Jan Münch; Robert W Doms; Frank Kirchhoff
Amino acid 324 in the simian immunodeficiency virus SIVmac V3 loop can confer CD4 independence and modulate the interaction with CCR5 and alternative coreceptors.
Journal of virology 2004;78(7):3223-32.
2003: Stefan Pöhlmann; Jie Zhang; Frédéric Baribaud; Zhiwei Chen; George J Leslie; George Lin; Angela Granelli-Piperno; Robert W Doms; Charles M Rice; Jane A McKeating
Hepatitis C virus glycoproteins interact with DC-SIGN and DC-SIGNR.
Journal of virology 2003;77(7):4070-80.
2003: George Lin; Graham Simmons; Stefan Pöhlmann; Frédéric Baribaud; Houping Ni; George J Leslie; Beth Haggarty; Paul Bates; Drew Weissman; James A Hoxie; Robert W Doms
Differential N-linked glycosylation of human immunodeficiency virus and Ebola virus envelope glycoproteins modulates interactions with DC-SIGN and DC-SIGNR.
Journal of virology 2003;77(2):1337-46.
2002: Frédéric Baribaud; Stefan Pöhlmann; George J Leslie; Frank Mortari; Robert W Doms
Quantitative expression and virus transmission analysis of DC-SIGN on monocyte-derived dendritic cells.
Journal of virology 2002;76(18):9135-42.
2002: Elizabeth J Soilleux; Lesley S Morris; George J Leslie; Jihed Chehimi; Qi Luo; Ernest L Levroney; John Trowsdale; Luis J Montaner; Robert W Doms; Drew Weissman; Nicholas Coleman; Benhur Lee
Constitutive and induced expression of DC-SIGN on dendritic cell and macrophage subpopulations in situ and in vitro.
Journal of leukocyte biology 2002;71(3):445-57.
2001: Benhur Lee; George J Leslie; Elizabeth J Soilleux; U O'Doherty; S Baik; Ernest L Levroney; K Flummerfelt; William J Swiggard; Nicholas Coleman; Michael H Malim; Robert W Doms
cis Expression of DC-SIGN allows for more efficient entry of human and simian immunodeficiency viruses via CD4 and a coreceptor.
Journal of virology 2001;75(24):12028-38.
2001: Stefan Pöhlmann; George J Leslie; Terri G Edwards; Todd Macfarlan; Jacqueline D Reeves; Kirsten Hiebenthal-Millow; Frank Kirchhoff; Frédéric Baribaud; Robert W Doms
DC-SIGN interactions with human immunodeficiency virus: virus binding and transfer are dissociable functions.
Journal of virology 2001;75(21):10523-6.
2001: Frédéric Baribaud; Stefan Pöhlmann; Tim D. Sparwasser; M T Kimata; Y K Choi; Beth Haggarty; Navid Ahmad; Todd Macfarlan; Terri G Edwards; George J Leslie; J Arnason; T A Reinhart; J T Kimata; Dan R Littman; James A Hoxie; Robert W Doms
Functional and antigenic characterization of human, rhesus macaque, pigtailed macaque, and murine DC-SIGN.
Journal of virology 2001;75(21):10281-9.
2001: Stefan Pöhlmann; Frédéric Baribaud; Benhur Lee; George J Leslie; Melissa D Sanchez; Kirsten Hiebenthal-Millow; Jan Münch; Frank Kirchhoff; Robert W Doms
DC-SIGN interactions with human immunodeficiency virus type 1 and 2 and simian immunodeficiency virus.
Journal of virology 2001;75(10):4664-72.
2001: Stefan Pöhlmann; Elizabeth J Soilleux; Frédéric Baribaud; George J Leslie; Lesley S Morris; John Trowsdale; Benhur Lee; Nicholas Coleman; Robert W Doms
DC-SIGNR, a DC-SIGN homologue expressed in endothelial cells, binds to human and simian immunodeficiency viruses and activates infection in trans.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(5):2670-5.
2000: Stefan Pöhlmann; Benhur Lee; Silke Meister; Mandy Krumbiegel; George J Leslie; Robert W Doms; Frank Kirchhoff
Simian immunodeficiency virus utilizes human and sooty mangabey but not rhesus macaque STRL33 for efficient entry.
Journal of virology 2000;74(11):5075-82.